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(12) United States Patent (10) Patent No.: US 9,683,047 B2 Smith Et Al

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(12) United States Patent (10) Patent No.: US 9,683,047 B2 Smith Et Al USOO9683 047B2 (12) United States Patent (10) Patent No.: US 9,683,047 B2 Smith et al. (45) Date of Patent: Jun. 20, 2017 (54) METHODS FOR TREATING PROGRESSIVE (56) References Cited MULTIPLE SCLEROSIS U.S. PATENT DOCUMENTS (71) Applicant: Genentech, Inc., South San Francisco, 3,773.919 A 11/1973 Boswell et al. CA (US) 4,120,649 A 10/1978 Schechter 4.485,045 A 11/1984 Regen (72) Inventors: Craig Smith, Seattle, WA (US); Peter $3.5 A g 3. S.tringfellow i. et al.1 S. Chin, San Francisco, CA (US) 4,676.980 A 6/1987 Segal et al. 4,816,567 A 3/1989 Cabilly et al. (73) Assignee: Genentech, Inc., South San Francisco, 4,861,579 A 8/1989 Meyer, Jr. et al. CA (US) 4,892,538 A 1/1990 Aebischer et al. 4,975,278 A 12/1990 Senter et al. (*) Notice: Subject to any disclaimer, the term of this 5,013,556 A 5/1991 Woodle et al. 5,114,721 A 5/1992 Cohen et al. patent is extended or adjusted under 35 5,208,020 A 5/1993 Chari et al. 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(Dec. 2003). “A Phase I Trial of Rituximab A 6LX 39/395 (2006.01) (Anti-CD20) for Treatment of Systemic Lupus Erythematosus.” A6 IK 9/00 (2006.01) Abstract LB9, Arthritis and Rheumatism 48(12): 3659. A6 IK 45/06 (2006.01) Anderson, D.W. et al. (Mar. 1992). “Revised Estimate of the (52) U.S. Cl. Prevalence of Multiple Sclerosis in the United States.” Ann Neu CPC .......... C07K 16/2887 (2013.01); A61 B 5/055 Anderson,3 (23. K.C. et al.(1984). “Expression of Human B Cell-Asso (2013.01); A61K 9/0019 (2013.01); A61 K ciated Anti 39/00 (2013.0). A61K.39/3955 (2013.01); B cell Differentiation.gens on Leukemias Blood and 66.424.433. Lymphomas: A Model of Human A61K 45/06 (2013.01); G0IN 33/686 (Continued) (2013.01); G06Q 99/00 (2013.01); A61 K 2039/505 (2013.01); A61K 2039/507 Primary Examiner — John Ulm (2013.01); A6 IK 2039/545 (2013.01); A61 K (74) Attorney, Agent, or Firm — Morrison & Foerster 2039/55 (2013.01); C07K 2317/24 (2013.01); LLP C07K 231 7/565 (2013.01); C07K 2317/76 (2013.01); G0IN 2800/52 (2013.01); G0IN (57) ABSTRACT 2800/7095 (2013.01) The present invention concerns methods for treating pro (58) Field of Classification Search gressive multiple Sclerosis (MS) in a patient, and an article None of manufacture with instructions for Such use. See application file for complete search history. 29 Claims, 18 Drawing Sheets US 9,683,047 B2 Page 2 (56) References Cited 2003/0219433 A1 11/2003 Hansen et al. 2003/02198.18 A1 11/2003 Bohen et al. 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