The Role of Thiocyanate in Modulating Myeloperoxidase Activity During Disease
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Protein Carbamylation Is a Hallmark of Aging SEE COMMENTARY
Protein carbamylation is a hallmark of aging SEE COMMENTARY Laëtitia Gorissea,b, Christine Pietrementa,c, Vincent Vuibleta,d,e, Christian E. H. Schmelzerf, Martin Köhlerf, Laurent Ducaa, Laurent Debellea, Paul Fornèsg, Stéphane Jaissona,b,h, and Philippe Gillerya,b,h,1 aUniversity of Reims Champagne-Ardenne, Extracellular Matrix and Cell Dynamics Unit CNRS UMR 7369, Reims 51100, France; bFaculty of Medicine, Laboratory of Medical Biochemistry and Molecular Biology, Reims 51100, France; cDepartment of Pediatrics (Nephrology Unit), American Memorial Hospital, University Hospital, Reims 51100, France; dDepartment of Nephrology and Transplantation, University Hospital, Reims 51100, France; eLaboratory of Biopathology, University Hospital, Reims 51100, France; fInstitute of Pharmacy, Faculty of Natural Sciences I, Martin Luther University Halle-Wittenberg, Halle 24819, Germany; gDepartment of Pathology (Forensic Institute), University Hospital, Reims 51100, France; and hLaboratory of Pediatric Biology and Research, Maison Blanche Hospital, University Hospital, Reims 51100, France Edited by Bruce S. McEwen, The Rockefeller University, New York, NY, and approved November 23, 2015 (received for review August 31, 2015) Aging is a progressive process determined by genetic and acquired cartilage, arterial wall, or brain, and shown to be correlated to the factors. Among the latter are the chemical reactions referred to as risk of adverse aging-related outcomes (5–10). Because AGE nonenzymatic posttranslational modifications (NEPTMs), such as formation -
Second Tranche HTS Subheading Product Description 2710.19.30
Second Tranche HTS Subheading Product Description 2710.19.30 Lubricating oils, w/or w/o additives, fr. petro oils and bitumin minerals (o/than crude) or preps. 70%+ by wt. fr. petro oils 2710.19.35 Lubricating greases from petro oil/bitum min/70%+ by wt. fr. petro. oils but n/o 10% by wt. of fatty acid salts animal/vegetable origin 2710.19.40 Lubricating greases from petro oil/bitum min/70%+ by wt. fr. petro. oils > 10% by wt. of fatty acid salts animal/vegetable origin 3403.19.10 Lubricating preparations containing 50% but less than 70% by weight of petroleum oils or of oils obtained from bituminous minerals 3403.19.50 Lubricating preparations containing less than 50% by weight of petroleum oils or of oils from bituminous minerals 3403.99.00 Lubricating preparations (incl. lubricant-based preparations), nesoi 3811.21.00 Additives for lubricating oils containing petroleum oils or oils obtained from bituminous minerals 3811.29.00 Additives for lubricating oils, nesoi 3901.10.10 Polyethylene having a specific gravity of less than 0.94 and having a relative viscosity of 1.44 or more, in primary forms 3901.10.50 Polyethylene having a specific gravity of less than 0.94, in primary forms, nesoi 3901.20.10 Polyethylene having a specific gravity of 0.94 or more and having a relative viscosity of 1.44 or more, in primary forms 3901.20.50 Polyethylene having a specific gravity of 0.94 or more, in primary forms, nesoi 3901.30.20 Ethylene copolymer: Vinyl acetate-vinyl chloride-ethylene terpoly w/ < 50% deriv of vinyl acetate, exc polymer aromatic/mod -
TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, And
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PYRIDINE (CAS NO. 110-86-1) IN F344/N RATS, WISTAR RATS, AND B6C3F1 MICE (DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 March 2000 NTP TR 470 NIH Publication No. 00-3960 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health FOREWORD The National Toxicology Program (NTP) is made up of four charter agencies of the U.S. Department of Health and Human Services (DHHS): the National Cancer Institute (NCI), National Institutes of Health; the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health; the National Center for Toxicological Research (NCTR), Food and Drug Administration; and the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention. In July 1981, the Carcinogenesis Bioassay Testing Program, NCI, was transferred to the NIEHS. The NTP coordinates the relevant programs, staff, and resources from these Public Health Service agencies relating to basic and applied research and to biological assay development and validation. The NTP develops, evaluates, and disseminates scientific information about potentially toxic and hazardous chemicals. This knowledge is used for protecting the health of the American people and for the primary prevention of disease. The studies described in this Technical Report were performed under the direction of the NIEHS and were conducted in compliance with NTP laboratory health and safety requirements and must meet or exceed all applicable federal, state, and local health and safety regulations. Animal care and use were in accordance with the Public Health Service Policy on Humane Care and Use of Animals. -
Heats of Formation of Certain Nickel-Pyridine Complex Salts
HEATS OF FORFATION OF CERTAIN NICKEL-PYRIDINE COLPLEX SALTS DAVID CLAIR BUSH A THESIS submitted to OREGON STATE COLLEGE in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE June l9O [4CKNOWLEDGMENT The writer wishes to acknowledge his indebtedness and gratitude to Dr. [4. V. Logan for his help and encour- agement during this investigation. The writer also wishes to express his appreciation to Dr. E. C. Gilbert for helpful suggestions on the con- struction of the calortheter, and to Lee F. Tiller for his excellent drafting and photostating of the figures and graphs. APPROVED: In Charge of ?ajor Head of Department of Chemistry Chairrian of School Graduate Comrittee Dean of Graduate School Date thesis is presented /11 ' Typed by Norma Bush TABLE OF CONTENTS HISTORICAL BACKGROUND i INTRODUCTION 2 EXPERIMENTAL 5 Preparation of the Compounds 5 Analyses of the Compounds 7 The Calorimeter Determination of the Heat Capacity 19 Determination of the Heat of Formation 22 DISCUSSION 39 41 LITERATURE CITED 42 TABLES I Analyses of the Compounds 8 II Heat Capacity of the Calorimeter 23 III Heat of Reaction of Pyridine 26 IV Sample Run and Calculation 27 V Heat of Reaction of Nickel Cyanate 30 VI Heat of Reaction of Nickel Thiocyanate 31 VII Heat of Reaction of Hexapyridinated Nickel Cyanate 32 VIII Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 33 IX Heat of Formation of the Pyridine Complexes 34 FI GURES i The Calorimeter 10 2 Sample Ijector (solids) 14 2A Sample Ejector (liquids) 15 3 Heater Circuit Wiring Diagram 17 4 heat Capacity of the Calorimeter 24 5 Heat of Reaction of Pyridine 28 6 Heat of Reaction of Hexapyridinated Nickel Cyanate 35 7 Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 36 8 Heat of Reaction of Nickel Cyanate 37 9 Heat of Reaction of Nickel Thiocyanate 38 HEATS OF FOW ATION OF CERTAIN NICKEL-PYRIDINE COMPLEX SALTS HISTORICAL BACKGROUND Compounds of pyridine with inorganic salts have been prepared since 1970. -
United States Patent Office Patented Jan
3,071,593 United States Patent Office Patented Jan. 1, 1963 2 3,071,593 O PREPARATION OF AELKENE SULFES Paul F. Warner, Philips, Tex., assignor to Philips Petroleum Company, a corporation of Delaware wherein each R is selected from the group consisting of No Drawing. Filed July 27, 1959, Ser. No. 829,518 5 hydrogen, alkyl, aryl, alkaryl, aralkyl and cycloalkyl 8 Claims. (C. 260-327) groups having 1 to 8 carbon atoms, the combined R groups having up to 12 carbon atoms. Examples of Suit This invention relates to a method of preparing alkene able compounds are ethylene oxide, propylene oxide, iso sulfides. Another aspect relates to a method of convert butylene oxide, a-amylene oxide, styrene oxide, isopropyl ing an alkene oxide to the corresponding sulfide at rela O ethylene oxide, methylethylethylene oxide, 3-phenyl-1, tively high yields without refrigeration. 2-propylene oxide, (3-methylphenyl) ethylene oxide, By the term "alkene sulfide' as used in this specifica cyclohexylethylene oxide, 1-phenyl-3,4-epoxyhexane, and tion and in the claims, I mean to include not only un the like. substituted alkene sulfides such as ethylene sulfide, propyl The salts of thiocyanic acid which I prefer to use are ene sulfide, isobutylene sulfide, and the like, but also 5 the salts of the alkali metals or ammonium. I especially hydrocarbon-substituted alkene sulfides such as styrene prefer ammonium thiocyanate, sodium thiocyanate, and oxide, and in general all compounds conforming to the potassium thiocyanate. These compounds can be reacted formula with ethylene oxide in a cycloparaffin diluent to produce 20 substantial yields of ethylene sulfide and with little or S no polymer formation. -
Cyanide in Bronchoalveolar Lavage Is Not Diagnostic for Pseudomonas Aeruginosa in Children with Cystic Fibrosis
Eur Respir J 2011; 37: 553–558 DOI: 10.1183/09031936.00024210 CopyrightßERS 2011 Cyanide in bronchoalveolar lavage is not diagnostic for Pseudomonas aeruginosa in children with cystic fibrosis M.D. Stutz*,#, C.L. Gangell*, L.J. Berry*, L.W. Garratt*, B. Sheil*,+ and P.D. Sly*,",+ on behalf of the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF)1 ABSTRACT: Early detection of the cyanobacterium Pseudomonas aeruginosa in the lungs of AFFILIATIONS young children with cystic fibrosis (CF) is considered the key to delaying chronic pulmonary *Division of Clinical Sciences, Telethon Institute for Child Health disease. We investigated whether cyanide in bronchoalveolar lavage (BAL) fluid could be used as Research and Centre for Child Health an early diagnostic biomarker of infection. Research, University of Western Cyanide was measured in 226 BAL samples (36 P. aeruginosa infected) obtained from 96 infants Australia. # and young children with CF participating in an early surveillance programme involving annual School of Biological Sciences and Biotechnology, Faculty of BAL. Sustainability, Environmental and Life Cyanide was detected in 97.2% of P. aeruginosa infected and 60.5% of uninfected samples. Sciences, Murdoch University and Cyanide concentrations were significantly higher in BALs infected with P. aeruginosa (median "Dept of Respiratory Medicine, (25th–75th percentile) 27.3 (22.1–33.3) mM) than those which were not (17.2 (7.85–23.0) mM, Princess Margaret Hospital for Children, Perth, Australia. p,0.001). The best sensitivity, specificity, positive and negative predictive values were obtained +These authors shared senior author with a cut-off concentration of 20.6 mM, and were 83%, 66%, 32% and 96%, respectively. -
Homocitrulline/Citrulline Assay Kit
Product Manual Homocitrulline/Citrulline Assay Kit Catalog Number MET- 5027 100 assays FOR RESEARCH USE ONLY Not for use in diagnostic procedures Introduction Homocitrulline is an amino acid found in mammalian metabolism as a free-form metabolite of ornithine (another amino acid not found in proteins but is involved in the urea cycle). Through the process of carbamylation, homocitrulline amino acid residues can also be formed in proteins. Carbamylation results from the binding of isocyanic acid with amino groups (isocyanic acid spontaneously derived from high concentrations of urea) and primarily leads to the formation of either N-terminally carbamylated proteins and/or carbamylated lysine side chains (forming homocitrulline residues) (Figure 1A). It is known that elevated urea directly induces the formation of potentially atherogenic carbamylated LDL (cLDL). High blood concentrations of urea leading to the carbamylation process were detected in uremic patients and patients with end-stage renal disease. Homocitrulline can be detected in larger amounts in the urine of individuals with urea cycle disorders. Citrulline is an amino acid very similar in structure to homocitrulline; however, the former is one methylene group shorter than the latter. In mammals, free citrulline is produced from free arginine during the enzymatic generation of nitric oxide (NO) by nitric oxide synthase (NOS) (Figure 1B). In addition, citrulline is synthesized from ornithine and carbamoyl phosphate in one of the main reactions of the urea cycle, a process that causes excretion of ammonia. Citrulline is not normally incorporated into proteins, but can be found in proteins due to post translational modification. The enzyme pepdidylarginine deiminase (PADI) can convert arginine to citrulline in the presence of calcium (Figure 1C). -
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, Or Isothiocyanate Radicals
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals Agriculture Handbook No. 403 Agricultural Research Service UNITED STATES DEPARTMENT OF AGRICULTURE Contents Page Methods 1 Results and discussion 3 Thiocyanic acid esters 8 Straight-chain nitriles 10 Propionitrile derivatives 10 Conclusions 24 Summary 25 Literature cited 26 This publication reports research involving pesticides. It does not contain recommendations for their use, nor does it imply that the uses discussed here have been registered. All uses of pesticides must be registered by appropriate State and Federal agencies before they can be recommended. CAUTION: Pesticides can be injurious to humans, domestic animals, desirable plants, and fish or other wildlife—if they are not handled or applied properly. Use all pesticides selectively and carefully. Follow recommended practices for the disposal of surplus pesticides and pesticide containers. ¿/áepé4áaUÁí^a¡eé —' ■ -"" TMK LABIL Mention of a proprietary product in this publication does not constitute a guarantee or warranty by the U.S. Department of Agriculture over other products not mentioned. Washington, D.C. Issued July 1971 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 - Price 25 cents House Fly Attractants and Arrestants: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals BY M. S. MAYER, Entomology Research Division, Agricultural Research Service ^ Few chemicals possessing cyanide (-CN), thio- cyanate was slightly attractive to Musca domes- eyanate (-SCN), or isothiocyanate (~NCS) radi- tica, but it was considered to be one of the better cals have been tested as attractants for the house repellents for Phormia regina (Meigen). -
Increased Concentration of Iodide in Airway Secretions Is Associated with Reduced RSV Disease Severity Rachel J
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Digital Repository @ Iowa State University Veterinary Pathology Publications and Papers Veterinary Pathology 2-2014 Increased Concentration of Iodide in Airway Secretions is Associated with Reduced RSV Disease Severity Rachel J. Derscheid Iowa State University, [email protected] Albert G. van Geelen Iowa State University Abigail R. Berkebile University of Iowa Jack M. Gallup Iowa State University, [email protected] Shannon J. Hostetter IFoowlalo Swta tthie Usn iaverndsit ay,dd smitjoneions@ial wasorktates.e duat: http://lib.dr.iastate.edu/vpath_pubs Part of the Veterinary Microbiology and Immunobiology Commons, and the Veterinary See next page for additional authors Pathology and Pathobiology Commons The ompc lete bibliographic information for this item can be found at http://lib.dr.iastate.edu/ vpath_pubs/65. For information on how to cite this item, please visit http://lib.dr.iastate.edu/ howtocite.html. This Article is brought to you for free and open access by the Veterinary Pathology at Iowa State University Digital Repository. It has been accepted for inclusion in Veterinary Pathology Publications and Papers by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. Increased Concentration of Iodide in Airway Secretions is Associated with Reduced RSV Disease Severity Abstract Recent studies have revealed that the human and nonrodent mammalian airway mucosa contains an oxidative host defense system. This three-component system consists of the hydrogen peroxide (H2O2)-producing enzymes dual oxidase (Duox)1 and Duox2, thiocyanate (SCN−), and secreted lactoperoxidase (LPO). -
Thiocyanate Pyridine Complexes
W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 5-2017 Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes Joseph V. Handy College of WIlliam & Mary Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the Inorganic Chemistry Commons Recommended Citation Handy, Joseph V., "Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes" (2017). Undergraduate Honors Theses. Paper 1100. https://scholarworks.wm.edu/honorstheses/1100 This Honors Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact [email protected]. Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes A thesis submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Chemistry from The College of William & Mary by Joseph Viau Handy Accepted for ____________________________ ________________________________ Professor Robert D. Pike ________________________________ Professor Deborah C. Bebout ________________________________ Professor David F. Grandis ________________________________ Professor William R. McNamara Williamsburg, VA May 3, 2017 1 Table of Contents Table of Contents…………………………………………………...……………………………2 List of Figures, Tables, and Charts………………………………………...…………………...4 Acknowledgements….…………………...………………………………………………………6 -
Intramolecular Alkoxycyanation and Alkoxyacylation Reactions: New Types of Alkene Difunctionalizations for the Construction of Oxygen Heterocycles John P
Angewandte. Highlights DOI: 10.1002/anie.201204470 Alkene Difunctionalization Intramolecular Alkoxycyanation and Alkoxyacylation Reactions: New Types of Alkene Difunctionalizations for the Construction of Oxygen Heterocycles John P. Wolfe* alkenes · catalysis · heterocycles · ketones · nitriles Saturated oxygen heterocycles, such as tetrahydrofurans and not require an exogenous carbon electrophile.[6,7] Instead, the dihydrobenzofurans, are important motifs in a myriad of carbon electrophile is covalently attached to the cyclizing biologically active compounds, including natural products and oxygen atom in the substrate, and the carboalkoxylations are pharmaceutical targets. Therefore, there has been consider- accomplished through activation of this CÀO bond by the able interest in the development of new synthetic methods for catalyst. Importantly, these two approaches lead to the the construction of these important structures.[1] Many tradi- formation of dihydrobenzofuran derivatives that bear func- tional approaches to the generation of these compounds tional groups (ketones or nitriles), which are convenient involve ring formation through intramolecular SN2 reactions handles for further elaboration of the molecule, and cannot be and related strategies. However, these approaches typically directly installed by using previously developed alkene lead to the formation of only one bond during ring closure and carboalkoxylation methods. often require somewhat complicated substrates.[1] The method of the Douglas group involves the use of Late transition metal catalyzed alkene carboalkoxylations a cationic RhI complex to catalyze the intramolecular are a subclass of alkene difunctionalization reactions[2] that alkoxyacylation of acylated 2-allylphenol derivatives have considerable utility for the construction of tetrahydro- (Scheme 2).[6] These reactions afford 2-acylmethyl dihydro- furans, dihydrobenzofurans, and related oxygen heterocycles. -
United States Patent Office Patented Dec
3,631,000 United States Patent Office Patented Dec. 28, 1971 2 SUMMARY OF THE INVENTION 3,631,000 SOCYANURATE-CONTAINING POLYSOCYA We have found that superior isocyanurate-containing NATES AND METHOD OF PREPARATION polyisocyanates are inexpensively prepared by the two Perry A. Argabright and Brian L. Philips, Littleton, Colo., step process of: (1) chloroalkylating a mono-substituted and Vernon J. Sinkey, South St. Paul, Minn., assignors benzene compound, and (2) reacting the polychloro to Marathon Oil Company, Findlay, Ohio alkylated benzene-substituted compounds with a metal No Drawing. Filed June 4, 1969, Ser. No. 830,541 cyanate in the conjoint presence of a bromide or iodide Int. C. C08g 22/18, 22/44 of an alkali metal or an alkaline earth metal, and in the U.S. C. 260-77.5 NC 1. Claims presence of an aprotic solvent, herein defined. The mole IO ratio of metal cyanate to the chloride in the polychloro alkylated benzene-substituted compound is from about ABSTRACT OF THE DESCLOSURE 0.8 to about 1.5 to produce the polyisocyanates. These Improved organic polyisocyanates are prepared by re polyisocyanate compositions are starting materials for acting chlorinated benzene-substituted compounds, espe Various polymeric systems, e.g. a rigid polyurethane foam cially chloromethylated aromatics, with metal cyanates in 5 produced by conventional polymerization or copolymeri the presence of a metal iodide or bromide and in the zation with an appropriate monomer (e.g. a polyester or presence of a dipolar aprotic solvent where the mole ratio polyether based polyol). Particularly preferred products of cyanate in the metal cyanate to chlorine in the chlo are polyurethane and polyurea foams, coatings, elasto rine-containing benzene-substituted compound is from mers and adhesives.