Photography and Photomicrography in 19Th Century Madras

Total Page:16

File Type:pdf, Size:1020Kb

Photography and Photomicrography in 19Th Century Madras HISTORICAL NOTES Photography and photomicrography in 19th century Madras Anantanarayanan Raman The science of light microscopy, which fected the technique of photographing light the earliest photomicrographic at- works using light from either the sun or small objects mounted on the platform of tempt made in India by Jesse Mitchell in an artificial source (e.g. incandescent a light microscope in 1839. In 1840, for Madras in the 1850s. light, mercury lamp), has today expanded the first time he displayed the photo- substantially involving a range of versatile micrograph of a flea in Liverpool2. Linnaeus Tripe and Frederick Fiebig – tools and techniques, such as phase Dancer’s efforts were based on calotype- master photographers contrast, polarized light, fluorescence, (also known as the ‘talbototype’) and interference contrast, dark field, confocal, daguerreotype-imprinting techniques. The Although the purpose of this note is to deconvolution and fluorescent-semicon- calotype and daguerreotype techniques recall Mitchell’s photomicrographic effort ductor nanocrystals (quantum dots). Pho- were developed independently: the for- in Madras, I consider a brief reference to tomicrography that runs with light mer by William Henry Fox Talbot contributions of Linnæus Tripe and Fre- microscopy too has diversified exten- (1800–1877) in London, and the latter by derick Fiebig, who made striking land- sively and grown impressionably. In Louis Jacques Mandé Daguerre (1787– scape- and macrophotographs in India in spite of the meteoric growth in sophisti- 1851) in Île de France. Both Talbot and the 1850s would provide a context. The cation in instruments used in modern sci- Daguerre independently trialled salts of web page of the Photographic Society of ence, which can measure quantities of Ag (serendipity?). To fix images perma- Madras5, established by Alexander materials and compounds precisely, nently Talbot used AgNO3 in combina- Hunter in 1857, refers to a few other key medical pathology is one specialty that tion with gallic acid, whereas Daguerre names in macrophotography in colonial relies greatly on microscopic observa- used AgI and NaCl solution. Daguerre’s Madras. tions to reach diagnoses. Especially in technique of using AgI was based on a Linnaeus Tripe (1822–1902), a captain the context of cancer, preparation of refined technique developed by Joseph in Madras Native Infantry (Madras quality photographs of smears and sec- Nicéphore Niépce, his work partner, who Army), is to be mentioned first. Tripe tioned tissues is vital. Treatment strate- used AgNO3 usually and AgCl occasion- was appointed the first official photogra- gies rely on the pathologist’s comments ally. pher of the Government of Madras in on the aetiology of the disease. A pho- Talbot attempted making photomicro- 1856, after a short stint in Burma6. tomicrograph is a highly valuable techni- graphs at magnifications less than 20×. Tripe’s task was to photographically cal document in science and industry. A In the book Die Fotographie als document historic structures of Madras quality photomicrograph is also an object Hilfsmittel Mikroskopischer Forschung Presidency, enabling the government to of beauty that evokes an appreciative (Verlag von Wilhelm Engelmann, Leip- launch conservation efforts. His panora- excitement in the viewer. Whereas zig, Germany, 1863), Joseph von Gerlach mic photos of the Great Temple of Ŧan- macrophotography evolved much earlier, refers to one Christian Joseph Berres javur (Figure 1 a) and wall inscriptions photography of microscopic objects (1796–1844), professor of anatomy in therein are archived at the Canadian Cen- (then referred to as ‘microphotography’, Vienna, as the pioneer photomicrogra- tre for Architecture (CCA) (Montréal, which literally means ‘production of pher, who used a vertical-solar micro- Quebéc, Canada). CCA’s acquisitions of minute photographs’) developed in the scope designed by von Gerlach in 1839. these images are from the personal col- 1830s. Thomas Wedgwood (Stafford- Berres seems to have fixed the micro- lections of James Bruce – the eighth shire, England, 1771–1805) in his article graphs using daguerreotype technique. Lord Elgin – who received them in 1860, ‘An account of a method of copying Berres wrote Anatomie der mik- while being the Viceroy of India, a posi- paintings upon glass, and of making pro- roskopischen Gebilde des menschlichen tion Lord Elgin held after being the Gov- files, by the agency of light upon nitrate Körpers (Anatomia microscopica cor- ernor General of Canada (1846–1854). of silver’ published in the Journal of the poris humani: Latin) published by Carl Tripe made calotype photographs (con- Royal Institution (1802–?) predicted the Gerold, Vienna in 1837. I could not see tact prints, 15 × 12″ size, used AgI to possibility of making photomicrographs1: the original text, but references to this print images), and also stereoscopic pho- book in classic-book catalogues indicate tographs using a stereo-binocular cam- ‘…, I have found that the image of that this is a finely illustrated medical era. Given that photography was in its small objects, produced by means of volume. Berres photographed ‘cells’. infancy then, the stand taken by the Gov- the solar microscope, may be copied Nonetheless, still being influenced by the ernment of Madras to appoint Tripe as without difficulty on prepared paper. ‘fibre theory’ in organism construction, the official government photographer and This will probably be a useful appli- Berres saw them as ‘bubbles’ and did not pressing him into action is noteworthy. cation of the method; that it may be recognize them as cells3. Frederick Fiebig is the second key per- employed successfully, however, it is Several European names sparkle in the son. Fiebig lived in Calcutta in 1840– necessary that the paper be placed at history of photomicrography4. Refer 1850s. The Bengal and Agra Directory & but a small distance from the lens.’ to Overney and Overney article4 to see Annual Register (1849–1850) refers to illustrations of the photomicroscopes of Fiebig as a piano teacher. In the 1840s, John Benjamin Dancer (1812–1887), a the 19th century and early 20th century. while at Calcutta, he took to photogra- professional optician in London per- The present note is an effort to bring to phy. He made several topographic 800 CURRENT SCIENCE, VOL. 101, NO. 6, 25 SEPTEMBER 2011 HISTORICAL NOTES Figure 1. a, A Linnaeus Tripe photograph of a part of the Brihadisvara temple, Ŧanjavur (1858); an albumen-silver print, from Tripe’s Photographic Views of Tanjore and Trivady. Source: http://www.cca.qc.ca/en/. b, A Frederick Fiebig photograph of Madras light house (1851). Source: picasaweb.google.com/Indian.Satheesh/MADRAS. Table 1. Negatives of the photomicrographs submitted by Jesse Mitchell to the Madras Photographic Society Exhibition held in Madras in May 1859* i. proboscis of blow fly [484 x] ii. parasite of tame goose [484 x] iii. parasite of fowl, an Acarus (currently valid name; erected by Linnaeus 1758; Astigmata: Acaridae) [3.969 x] iv. a butterfly’s scale, Thecla (currently valid name; erected by Linnaeus 1758; Lepidoptera: Lycanidae) [276.676 x] v. ditto of item (iv) [672.400 x] vi. a butterfly’s scale, Polyommatus (currently valid name; erected by Linnaeus 1763; Lepidoptera: Nymphalidae) [276.676 x] vii. parasite of pig [484 x] viii. proboscis of blow fly [1.600 x] ix. house flea [484 x] (a siphonapteran) x. trophi of a wasp [484 x] xi. wing of mosquito [484 x] xii. mouth of larva of ant lion [484 x] xiii. scale of Morpho menelaus (currently valid name; erected by Linnaeus 1768; Lepidoptera: Lycanidae) (Note: Is this a correct determination? Species of Morpho are not known in India) [72.900 x] xiv. Arnee muslin at Rs 12½ per yard [2.500 x] [‘Arnee muslin’ is the cotton fabric produced in the town Ãrni (12°67′N; 79°28′E) in Tiruannamalai District, near Madras] xv. Coccus lacca from mango tree [2.500 x] (current valid name: Kerria lacca (Kerr 1792); Hemiptera: Coccoidea: Kerridae) xvi. exuvia of bed bug showing lancets [484 x] (Hemiptera: Cimicidae) xvii. tarsus of a grasshopper [484 x] (Orthoptera) xviii. exuvia of a spider showing the jaws [484 x] *Text is presented as it is in the original; magnifications supplied in the original file are indicated in square brackets. Wherever appropriate, I have supplemented comments and remarks (‘Times’ typeface) ‘translating’ the 1850 data to the current time. photographs of Calcutta. He too used the ence (MJLS)8 (p. 174) under the section Mitchell submitted 18 negatives made then state-of-the-art photo-printing tech- Proceedings of Scientific Societies (Pro- in an achromatic compound microscope nique, viz. calotyping. While travelling ceedings of the Photographic Society (Table 1) with the following declaration: to Colombo (Ceylon) from Calcutta, en [sic. ‘of Madras’]) includes the following route, he touched Madras and took pho- notation: ‘The Negatives were taken by the 7 tos of the place (e.g. Figure 1 b). The Collodion process and are untouched. only reference to his photographs made The proofs were toned by Hardwick’s ‘Arrangements made for the appro- of and in Madras occurs in ‘Photography new Alkaline Chloride of Gold pro- aching Exhibition, proposed to open in Madras’ published in the Illustrated cess.’ (ref. 8, pp. 195–196) Indian Journal of Arts (Part 4, February on the first Thursday of next month (sic. “May 1859”).’ 1832, p. 32), which refers to his Madras No details on the photomicroscopic unit, visit in 1852. No other biographic details which Mitchell used in Madras to create are traceable; that he was a German by In the report of the Committee appointed the prize-winning photos are traceable. birth and from lithography he took to to adjudicate the Photographic Society’s In high likelihood, he may have used a photography remain unverified. medals dated 12 May 1859 (p. 175), ‘custom-made’ camera adapting it to the besides references to the medals awarded achromatic compound microscope that Photomicrography in Madras and to landscape photographs of entries that he had.
Recommended publications
  • Building the Analytical Foundations for Greening the Financial System
    Building the analytical foundations for greening the financial system The first report of the International Network for Sustainable Financial Policy Insights, Research and Exchange – INSPIRE About INSPIRE The International Network for Sustainable Financial Policy Insights, Research and Exchange (INSPIRE) is co-chaired by Ilmi Granoff, Director of ClimateWorks Foundation’s sustainable finance programme, and Nick Robins, professor in practice for sustainable finance at the Grantham Research Institute on Climate Change and the Environment at the London School of Economics and Political Science (LSE). INSPIRE’s trajectory is guided by an Advisory Committee who provide domain expertise independently but in close interface with the work priorities of the Network for Greening the Financial System (NGFS). Chaired by Nick Robins, the INSPIRE Advisory Committee consists of Pierre Monnin (Council on Economic Policies), Jakob Thomä (2° Investing Initiative), and Yao Wang (International Institute of Green Finance of Central University of Finance and Economics). Philanthropic support for INSPIRE is provided by ClimateWorks, and commissioning research is seed-funded by the ClimateWorks and Children’s Investment Fund Foundation. www.climateworks.org/inspire/ Contact: [email protected] About the secretariat institutions The Grantham Research Institute on Climate Change and the Environment was established in 2008 at the London School of Economics and Political Science (LSE). The Institute brings together international expertise on economics, finance, geography, the environment, international development and political economy to establish a world-leading centre for policy-relevant research, teaching and training in climate change and the environment. It is funded by the Grantham Foundation for the Protection of the Environment, which also funds the Grantham Institute – Climate Change and the Environment at Imperial College London.
    [Show full text]
  • The Tropics, Science, and Leishmaniasis: an Analysis of the Circulation of Knowledge and Asymmetries História, Ciências, Saúde - Manguinhos, Vol
    História, Ciências, Saúde - Manguinhos ISSN: 0104-5970 [email protected] Fundação Oswaldo Cruz Brasil Guedes Jogas Jr., Denis The tropics, science, and leishmaniasis: an analysis of the circulation of knowledge and asymmetries História, Ciências, Saúde - Manguinhos, vol. 24, núm. 4, octubre-diciembre, 2017, pp. 1- 20 Fundação Oswaldo Cruz Rio de Janeiro, Brasil Available in: http://www.redalyc.org/articulo.oa?id=386154596011 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative The tropics, science, and leishmaniasis The tropics, science, and leishmaniasis: an JOGAS JR., Denis Guedes. The tropics, analysis of the circulation science, and leishmaniasis: an analysis of the circulation of knowledge and of knowledge and asymmetries. História, Ciências, Saúde – Manguinhos, Rio de Janeiro, v.24, n.4, asymmetries out.-dez. 2017. Available at: http://www. scielo.br/hcsm. Abstract The article investigates the process of circulation of knowledge which occurred during the first decades of the twentieth century between the South American researchers Edmundo Escomel (Peru) and Alfredo Da Matta (Brazil) and the Europeans Alphonse Laveran (France) and Patrick Manson (England) with regard to the definition and validation of espundia as a disease specific to South America, while simultaneously the need to insert this illness into the newly created group of diseases called the “leishmaniasis” was proposed. Sharing recent concerns in considering historical research beyond the limits imposed by the Nation-state as a category that organizes narratives, it dialogs with some apologists of global and transnational history, situating this specific case within this analytical perspective.
    [Show full text]
  • Eponyms in the Dermatology Literature Linked to United Kingdom
    Historical Article DOI: 10.7241/ourd.20133.105 EPONYMS IN THE DERMATOLOGY LITERATURE LINKED TO UNITED KINGDOM Khalid Al Aboud1, Ahmad Al Aboud2 1Department of Public Health, King Faisal Hospital, Makkah, Saudi Arabia Source of Support: 2Dermatology Department, King Abdullah Medical City, Makkah, Saudi Arabia Nil Competing Interests: None Corresponding author: Dr. Khalid Al Aboud [email protected] Our Dermatol Online. 2013; 4(Suppl. 2): 417-419 Date of submission: 07.05.2013 / acceptance: 11.07.2013 Cite this article: Khalid Al Aboud, Ahmad Al Aboud: Eponyms in the dermatology literature linked to United Kingdom. Our Dermatol Online. 2013; 4(Suppl. 2): 417-419. The United Kingdom of Great Britain and Northern Ireland, Revolution from the 17th century and the United Kingdom commonly known as the United Kingdom (UK) and Britain, is a led the Industrial Revolution from the 18th century, and has sovereign state located off the north-western coast of continental continued to produce scientists and engineers credited with Europe. important advances [1]. The United Kingdom is a developed country and remains a great There are several eponyms in dermatology literature, which are power with considerable economic, cultural, military, scientific linked to United Kingdom. and political influence internationally [1]. In Table I [2-14], we highlighted on some examples of eponyms England and Scotland were leading centres of the Scientific in dermatology literature, linked to United Kingdom. Eponyms in the dermatology Remarks literature linked to United Kingdom Anderson-Fabry disease [2] Also known as Fabry disease, angiokeratoma corporis diffusum and alpha- galactosidase A deficiency;is a rare X-linked lysosomal storage disease, which can cause a wide range of systemic symptoms.
    [Show full text]
  • Frederick W. Knight I. 1999 Introduction
    NOTES ON THE FAMILY OF RONAYNE OR RONAN OF COUNTIES CORK AND WATERFORD Frederick W. Knight Journal of the Cork Historical and Archaeological Society (As they appeared in the “Journal” of the Cork Historical and Archaeological Society for April-June, July-September, October- December, 1916; and April-June, July-September, 1917) This edition—including the index—produced by Thomas Ronayne, Detroit, Michigan, for purposes of genealogical research, August, 1998. I. 1999 Introduction • LL.D.—Legum Doctor; i.e., Doctor of Laws. • M.L.B.—Marriage License Bond. As I read through these Notes, I noticed every so often that I didn’t know what something meant, or I wondered who • MP—Member of Parliament. somebody was, or I was just curious about time frames. In • MS—manuscript. those cases, I’ve added footnotes and reference material. I’ve • MSS—manuscripts. (mostly) left things alone, except for “fixing” typographical • ob.—died. errors (and, probably, adding a few of my own). • T.C.D.—Educated at Trinity College, Dublin. I’ve changed all references to Queenstown to the original Cobh; i.e., Cove of Cork. The town was renamed Queenstown • unkn.—unknown. after a visit by Queen Victoria in 1849, it remained so until • unm.—unmarried. 1922 when it was changed back to the original name. In particular you will notice that people lost their rights Also, note that references to “… the current …” or “… and property by being attainted. Attainder was the conse- today …” mean up to the publication date of the original quence of a judicial or legislative sentence for treason or fel- notes; i.e., 1917, during the first World War, when Ireland still ony, and involved the forfeiture of all the real and personal “belonged” to England.
    [Show full text]
  • The British Army's Contribution to Tropical Medicine
    ORIGINALREVIEW RESEARCH ClinicalClinical Medicine Medicine 2018 2017 Vol Vol 18, 17, No No 5: 6: 380–3 380–8 T h e B r i t i s h A r m y ’ s c o n t r i b u t i o n t o t r o p i c a l m e d i c i n e Authors: J o n a t h a n B l a i r T h o m a s H e r r o nA a n d J a m e s A l e x a n d e r T h o m a s D u n b a r B general to the forces), was the British Army’s first major contributor Infectious disease has burdened European armies since the 3 Crusades. Beginning in the 18th century, therefore, the British to tropical medicine. He lived in the 18th century when many Army has instituted novel methods for the diagnosis, prevention more soldiers died from infections than were killed in battle. Pringle and treatment of tropical diseases. Many of the diseases that observed the poor living conditions of the army and documented are humanity’s biggest killers were characterised by medical the resultant disease, particularly dysentery (then known as bloody ABSTRACT officers and the acceptance of germ theory heralded a golden flux). Sanitation was non-existent and soldiers defecated outside era of discovery and development. Luminaries of tropical their own tents. Pringle linked hygiene and dysentery, thereby medicine including Bruce, Wright, Leishman and Ross firmly contradicting the accepted ‘four humours’ theory of the day.
    [Show full text]
  • Interactions Between Parasite and Host in Human Visceral Leishmaniasis
    Harizanov, et al., J Cytol Tissue Biol 2014, 1: 001 DOI: 10.24966/CTB-9107/100001 HSOA Journal of Cytology and Tissue Biology Mini Review protozoa. Subsequently, Ronald Ross, using Leishmans staining technique named these protozoan microorganisms “Leishman Interactions between Parasite bodies”, and Manson named them “Leishman–Donovan bodies”-in memory of the two English scientists. The name, “kala-azar” (black and Host in Human Visceral disease) was given by McNaught, who described the disease in India. Swaminath et al., using volunteers proved that the disease is Leishmaniasis transmitted to humans by insects and found those specific biological Harizanov*, Rumen N and Kaftandjiev Iskren T carriers are bloodsucking insects from genus Phlebotomus. For first time Rogers was able to cultivate the parasite in citrated blood, but Department of Parasitology and Tropical Medicine, National Center of his attempts to maintain the strain by passaging were unsuccessful. Infectious and Parasitic Diseases, Sofia, Bulgaria Later, Ch. Nicolle was able to cultivate and maintain Leishmania strain by passaging and also to induce experimental disease in dogs and monkeys. He first highlights the epidemiological link between man and dog [1,2]. Etiology Abstract Taxonomy Leishmaniasis is one of the most important Neglected Tropical Genus Leishmania, depending on which part of the alimentary Diseases (NTDs) affecting mainly the poorest social groups in many countries of the world. Visceral form of the disease is caused by canal of the insect vector carries out its development is divided into protozoa belonging to Leishmania donovani complex. The clinical two subgenera-Leishmania and Viannia. Promastigotes relating to manifestations arise from a number of complex interactions between subgenera Leishmania, realize part of their biological cycle in front cells of the causative agent and the host.
    [Show full text]
  • Medical Alumni Newsletter 2013
    Medical Alumni and Faculty Newsletter No. 12 December 2013 Contents Diary in Pictures p2 Introduction / Welcome p3 The Hunt for Dicer 1 – Dr. Paul O’Brien p4 Is it a Boy or a Child – Dr. Fergus Moylan p7 Alumni Interview – Prof. Tony Gallagher, Professor of Technology Enhanced Learning Dr. Dan Burke, Prof Katy Keohane Prof. Michael Molloy, Dr. Con Murphy, p9 Jennings Gallery – Dr. Bridget Maher Dr. Will Fennell p10 Summer Elective Report – Rory Crotty p10 Dr. Henry Hutchinson Stewart Scholarships – Dr. Bridget Maher p11 €6 million CU Cystic Fibrosis Research Award – Dr. Barry Plant p12 Today’s research is tomorrows health care Dr. Pat Cogan-Tangney, Prof Paul Finucane Dr. Jim O’Regan, Dr. Rory O’Brien, – Prof. Jonathan Hourihane Mr. Peter Ganey, Mr. Fionnan O’Carroll p13 Improving Care for People with Diabetes: A Population Approach to Prevention and Control – Prof . Patricia Kearney p14 Charles Donovan Memorial Lecture - Introduction – Prof. Katy Keohane p15 Charles Donovan Memorial Lecture – Prof .Fergus Shanahan Prof. Barry Ferriss, Dr Eamann Breatnach Prof. Cillian Twomey, Dr. Bill O’Dwyer p16 Medical Alumni & Faculty Scientific Conference 2013 p18 Appreciations Dr. Pat Sullivan, Dr Tom Crotty Dr. Colm Quigley, Dr Dan Burke Prof. Catherine Keohane Introduction Welcome to the 12th newsletter of the UCC Medical Alumni and Faculty Association am delighted to represent the UCC Medi- the Western Gateway Building, the Glucks- Sadly, we have been informed of the deaths I cal Alumni and Faculty as Chairman of the man Gallery and main campus can be of former teachers and colleagues in the Alumni Committee. arranged.
    [Show full text]
  • Emphasis on Kala-Azar in South Asia 2
    Overview of Leishmaniasis with Special 1 Emphasis on Kala-azar in South Asia 2 Kwang Poo Chang, Bala K. Kolli and Collaborators 3 4 Contents 5 1 Global Overview of Leishmaniasis .......................................................... 2 6 1.1 Disease Types .......................................................................... 2 7 1.2 Disease Incidence/Distribution ......................................................... 2 8 1.3 Transmission ............................................................................ 3 9 1.4 Diagnosis ............................................................................... 5 10 1.5 Prevention ............................................................................... 6 11 1.6 Treatment ............................................................................... 8 12 1.7 Epidemiology Mathematical Modeling ................................................ 9 13 1.8 Control Programs ....................................................................... 9 14 2 Leishmaniasis in South Asia ................................................................. 10 15 2.1 Clinico-epidemiological Types ........................................................ 10 16 2.2 Indian Kala-azar or visceral leishmaniasis ............................................ 12 17 3 Experimental Leishmaniasis ................................................................. 16 18 3.1 Causative Agents ....................................................................... 16 19 3.2 Host-Parasite Interactions .............................................................
    [Show full text]
  • Eponyms in the Dermatology Literature Linked to United Kingdom
    Historical Article DOI: 10.7241/ourd.20133.105 EPONYMS IN THE DERMATOLOGY LITERATURE LINKED TO UNITED KINGDOM Khalid Al Aboud1, Ahmad Al Aboud2 1Department of Public Health, King Faisal Hospital, Makkah, Saudi Arabia Source of Support: 2Dermatology Department, King Abdullah Medical City, Makkah, Saudi Arabia Nil Competing Interests: None Corresponding author: Dr. Khalid Al Aboud [email protected] Our Dermatol Online. 2013; 4(Suppl. 2): 417-419 Date of submission: 07.05.2013 / acceptance: 11.07.2013 Cite this article: Khalid Al Aboud, Ahmad Al Aboud: Eponyms in the dermatology literature linked to United Kingdom. Our Dermatol Online. 2013; 4(Suppl. 2): 417-419. The United Kingdom of Great Britain and Northern Ireland, Revolution from the 17th century and the United Kingdom commonly known as the United Kingdom (UK) and Britain, is a led the Industrial Revolution from the 18th century, and has sovereign state located off the north-western coast of continental continued to produce scientists and engineers credited with Europe. important advances [1]. The United Kingdom is a developed country and remains a great There are several eponyms in dermatology literature, which are power with considerable economic, cultural, military, scientific linked to United Kingdom. and political influence internationally [1]. In Table I [2-14], we highlighted on some examples of eponyms England and Scotland were leading centres of the Scientific in dermatology literature, linked to United Kingdom. Eponyms in the dermatology Remarks literature linked to United Kingdom Anderson-Fabry disease [2] Also known as Fabry disease, angiokeratoma corporis diffusum and alpha- galactosidase A deficiency;is a rare X-linked lysosomal storage disease, which can cause a wide range of systemic symptoms.
    [Show full text]
  • Current Treatment of Leishmaniasis: a Review Lianet Monzote*
    The Open Antimicrobial Agents Journal, 2009, 1, 9-19 9 Open Access Current Treatment of Leishmaniasis: A Review Lianet Monzote* Parasitology Department, Institute of TropicalMedicine “Pedro Kourí”, Havana City, Cuba Abstract: The World Health Organization has classified the leishmaniasis as a major tropical disease. An effective vaccine against leishmaniasis is not available and chemotherapy is the only effective way to treat all forms of disease. However, current therapy is toxic, expensive and the resistance has emerged as a serious problem, which has compelled the search for new antileishmanial agents. The aim of this article is to review the current aspects of the pharmacology of leishmaniasis, giving an overview from current agents clinically used to new compounds under development. Pentavalent antimonials are still the first choice among drugs used for the treatment of leishmaniasis. Alternatively, amphotericin B, pentamidine, miltefosine and paromomycin can be used. The search for new drugs is a perpetual process; including synthetic products and compounds isolated from natural sources. The current scenario of antileishmanial drugs constitute the results of effort by academics, researchers and sponsorships in order to obtain drugs available, efficient and less toxic to people infected by Leishmania parasites. Keywords: Leishmaniasis, treatment, drug, pharmacology, parasite. 1. INTRODUCTION disease affects around 12 million people worldwide, with an annual incidence of approximately two million new cases Leishmania are protozoan parasites belonging to the and 350 million are living at risk to be infected. Reported family Trypanosomatidae that causes high morbidity and from 88 subtropical and tropical countries has been recorder mortality levels with a wide spectrum of clinical syndromes from Indian subcontinent, Southern Europe and Western [1].
    [Show full text]
  • Discovery of Leishmania Donovani
    Medical History, 1983, 27: 203-213. THE IDENTIFICATION OF KALA AZAR AND THE DISCOVERY OF LEISHMANIA DONOVANI by MARY E. GIBSON* IN the years following 1858, when the British government formally assumed power over the whole of British India, the government of Bengal became concerned by reports of an epidemic of quinine-resistant fever occurring in the district of Burdwan in Lower Bengal. The mortality was so great that the population, the productivity of the land, and consequently the government revenue were greatly diminished. Some eight to ten years after the epidemic of "Burdwan fever" had been brought to official attention, the Deputy Commissioner of the Garo Hills in south-west Assam reported that a particularly virulent form of fever, which resembled malaria, was decimating the population and that they were asking to be relieved of hut tax as a result. This disease was known locally as kala azar or black disease. Kala azar is characterized by intermittent or remittent fever and enlargement of the spleen; in the later stages there is emaciation, anaemia, and darkening of the skin. Napier and Muir describe the onset as occurring in one of three ways, malarial, typhoid, and insidious,' but without a microscope it can be impossible to diagnose accurately in the initial stages. Before the 1820s, the history of kala azar is obscure. Garcia da Orta, a Portuguese physician and botanist who published Coloquios dos simples e drogas he cousas medicinais da India at Goa in 1563, described a case of fever that he cured by dosing the patient with ginger conserve and root ofChina in cinnamon water.
    [Show full text]
  • LEISHMAN-DONOVAN BODIES and DONOVANIASIS*T SIR WILLIAM BOOG LEISHMAN, 1865-1926 CHARLES DONOVAN, 1863-1951 by HAMILTON BAILEY and W
    Br J Vener Dis: first published as 10.1136/sti.35.1.8 on 1 March 1959. Downloaded from Brit. J. vener. Dis. (1959), 35, 8. LEISHMAN-DONOVAN BODIES AND DONOVANIASIS*t SIR WILLIAM BOOG LEISHMAN, 1865-1926 CHARLES DONOVAN, 1863-1951 BY HAMILTON BAILEY AND W. J. BISHOP Leishman-Donovan bodies are small round or proficient in its use. At Netley he spent a great deal oval bodies found in the spleen and liver of patients of his spare time in the pathological department, suffering from kalaazar, a tropical disease charac- then under the direction of (Sir) Almroth Wright.§ terized by anaemia, irregularly remittent fever, and He was able to watch the development of Wright's emaciation. The bodies are the intra-cellular forms researches on anti-typhoid vaccination, in which he of the protozoan parasite Leishmania donovani, was later to take an important part. In 1900 he was which causes the disease. appointed Assistant Professor of Pathology at Netley, and at this time he elaborated the stain for William Boog Leishman was born in Glasgow, the blood, now known universally as Leishman's stain. son of William Leishman, I a distinguished obstetri- Leishman made his great discovery in the follow- cian of that city. William Leishman, junior, was ing way: educated at Westminster School and at the Uni- In 1900, Private B., invalided from India with attacks versity of Glasgow, where he graduated M.B., C.M. of pyrexia, anaemia, and enlargement of the spleen was in 1886. In 1887 he entered the army medical service, admitted to Netley Hospital for investigation and treat- and he spent several years in India before being ment.
    [Show full text]