Emtree Terms Changed in May 2021 1

Emtree Terms Added and Changed (May 2021)

This is an overview of new terms added and changes made in the second Emtree release in 2021.

Overall, Emtree has grown by 1150 preferred terms (140 drug terms and 1010 non-drug terms) compared with the previous version released in January 2021. In total Emtree now counts 90095 preferred terms.

Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept.

The terms added and changed are summarized below and specified in detail on the following pages.

Emtree Terms Added in May 2021 1228 new terms (including 78 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version May 2021 (compared to January 2021):

◼ 179 drug terms (terms assigned to the Chemicals and Drugs facet). ◼ 1049 non-drug terms (terms not assigned as Chemicals and Drugs).

The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2021 (typically as candidate terms), sometimes for several years, before they were added to Emtree.

Emtree Terms Changed in May 2021 78 terms (39 drug terms and 39 non-drug terms) from Emtree January 2020 have been replaced by 76 different terms in May 2021 (39 drug terms and 37 non-drug terms).

Of these, 58 terms (28 drug terms and 30 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2021; the remaining 18 replacement terms (11 drug terms and 7 non-drug terms) were already present in Emtree.

No drug term was replaced by a non-drug term, no non-drug term was replaced by a drug term. No preferred terms were deleted.

Changes are presented in alphabetical order of the new terms. Emtree Terms Changed in May 2021 2

Drug terms

2 hydroxyoleic acid covaxin AAV8-hPDE6A cti 1601 abequolixron defosbarasertib acasunlimab delandistrogene moxeparvovec acavameran dimethyl fumarate acazicolcept dimethyl fumarate plus monoethyl acp 015 fumarate ad5 ncov vaccine domvanalimab adagrasib eb003 adezmapimod ebaresdax aficamten ebdarokimab ag0302-covid19 vaccine ebvaciclib alomfilimab ecubectedin alvocidib edaxeterkib amlitelimab eflimrufusp alfa anbenitamab elraglusib at 100 emavusertib atamparib encoberminogene rezmadenovec atuzaginstat ensovibep aumolertinib enuvaptan avr rd 02 eramkafusp alfa baculoviral IAP repeat containing protein 1 erfonrilimab baculoviral IAP repeat containing protein 2 ervogastat baculoviral IAP repeat containing protein 5 esafoxolaner plus eprinomectin plus benzathine penicillin plus lidocaine praziquantel bevufenogene nofeparvovec etavopivat bnt 162 vaccine etrumadenant botensilimab exagamglogene autotemcel buzhong yiqi fesomersen cabotegravir plus rilpivirine finotonlimab cadonilimab firzacorvir caffeine plus ibuprofen foscenvivint caficrestat fowlpox infectious laryngotracheitis vaccine casirivimab plus imdevimab govorestat cavrotolimod guretolimod choriogonadotropin alfa (drug) hs214 choriogonadotropin beta (drug) ibrigampar cilgavimab plus tixagevimab ilofotase alfa cimpuciclib imunor Clostridium perfringens inetagugene geperpavec vaccine irsenontrine Clostridium perfringens vaccine isaralgagene civaparvovec cm 101 (bacterial toxin) isuzinaxib cm 101 (monoclonal antibody) jinhua qinggan cofirasersen labuvirtide copper histidinate larsucosterol Emtree Terms Changed in May 2021 3 latozinemab retlirafusp alfa ledelabricin alfa ropanicant lemzoparlimab runimotamab libvatrep sapablursen licaminlimab sesiclenegene cosaparvovec liuwei dihuang sibeprenlimab locnartecan sirelretigene suboparvovec lonigutamab sputnik light (vaccine) lonigutamab ugodotin sudubrilimab low molecular weight dextran sulfate sunobinop lusvertikimab surzebiclimab magnesium sulfate plus potassium chloride tacatresgene autoleucel plus sodium sulfate tadnersen mibavademab tasurgratinib mipicoledine temgicoluril monoethyl fumarate tifcemalimab nadecnemab tigulixostat nanvuranlat tolinapant navtemadlin tomligisiran nemtabrutinib torudokimab nendratareotide tozorakimab nendratareotide uzatansine transcrocetin nilofabicin ugodotin ninerafaxstat ulevostinag nivadstrocel ulotaront nivatrotamab unasnemab onilcamotide usmarapride onzigolide uzatansine opelconazole valiloxybate ordesekimab vanglusagene ensiparvovec oremepermin alfa varoglutamstat orludodstat vemircopan osugacestat vgx 1027 ozarlimogene inteplasmid vixtimotamab palopegteriparatide voxeralgagene autotemcel peboctocogene camaparvovec vtx 801 pelgifatamab yupingfeng pelgifatamab corixetan zabedosertib picropodophyllin zaloglanstat plazinemdor zamtocabtagene autoleucel plonmarlimab zeluvalimab prusogliptin zeteletinib pucotenlimab zilebesiran pulrodemstat zilovertamab quemliclustat zilovertamab vedotin ren001 Emtree Terms Changed in May 2021 4 Emtree Terms Changed in May 2021 5

Non Drug terms

abdominal fluid drainage system angiotensin converting enzyme 2 deficiency aberrant behavior checklist ankle surgery absolute humidity antarctic circumpolar current absolute lymphocyte count antibody microarray absolute neutrophil count antibody therapy accident insurance antifibrotic therapy Acetobacter pasteurianus Anton's syndrome Achatina fulica applesauce active music therapy paralysis acute cholestatic hepatitis artisanal production acute diverticulitis Asthma Quality of Life Questionnaire acute drug induced hepatitis Astrakhan spotted fever acute fatty liver of pregnancy asymptomatic coronavirus disease 2019 acute hepatitis D Athens Insomnia Scale acute hepatitis E Atlantic meridional overturning circulation acute hypercapnic respiratory failure atomic clock acute hypoxemic respiratory failure atrium retractor acute ischemic stroke attack rate acute limb ischemia attenuated total reflectance Fourier acute lupus pneumonitis transform infrared spectroscopy acute necrotizing hemorrhagic autocrine signaling encephalopathy automated dispensing system acute severe ulcerative colitis automated teller machine acute transverse myelitis automatic shaker acute viral hepatitis awake craniotomy adipose tissue awake tracheal intubation adult learner bacterial artificial chromosome array African spotted fever bacterial bioluminescence Agrobacterium vitis bacterial zoonosis airway opening pressure balsamic vinegar airway sampling Bannwarth syndrome airway suction catheter Barmah Forest virus infection alcoholic hepatitis Bat coronavirus RaTG13 alcoholic steatohepatitis BCR signaling Alkhurma hemorrhagic fever Behavioral Pain Scale altered gravity Berlin criteria alveolar lymphocytosis Big Five Inventory Amazon black fever bilateral ambulance robot bilateral salpingo-oophorectomy American Society of Anaesthesiologists score binge watching anaplastic lymphoma kinase test kit biological adaptation anemia of chronic disease biological age anemia of prematurity bipolar hemiarthroplasty Emtree Terms Changed in May 2021 6 birth length cerebrospinal fluid abnormality Bitis gabonica cervicotomy blackwater fever cestode zoonosis bladder function test checkpoint inhibitor pneumonitis blood fractionation chemesthesis blood purification chemical and drug induced liver injury BMP signaling chemical interesterification bone marrow mesenchymal stem cell chemiluminescent microparticle bone marrow mesenchymal stem cell immunoassay transplantation chemokine signaling Borg dyspnea scale chewiness Borrelia turicatae Child Depression Inventory bovine chromogenic in situ hybridization bovine babesiosis chromophobe renal cell carcinoma breast-conserving surgery chronic alcoholic hepatitis Brescia COVID respiratory severity scale chronic cholestatic hepatitis Brief COPE Inventory chronic diverticulitis Brief Illness Perception Questionnaire chronic drug induced hepatitis Brixia score chronic hepatitis D Brucella melitensis 16M chronic hepatitis E bubonic chronic hypercapnic respiratory failure buffy coat (procedure) chronic hypoxemic respiratory failure Bungarus caeruleus chronic infection burglary chronic ischemic stroke Buteyko breathing chronic low grade inflammation bystander effect (cell) chronic obstructive bronchitis bystander effect (psychology) chronic viral hepatitis bystander suppression CL1-1 cell line (lung adenocarcinoma) calisthenics CL1-3 cell line cancer signaling classical conditioning canine babesiosis cleaning robot canonical Wnt signaling cleaning staff capillary gas chromatograph clear cell renal cell carcinoma Carangiformes Clinical Frailty Scale carbohydrate microarray clinical laboratory standard carbon dioxide test kit clock (device) cardiac asthma clouding of consciousness castration sensitive prostate cancer cloverleaf skull caval valve implant coagulation analyzer cell cell recognition coating uniformity cell culture time codon adaptation index cell matrix interaction Cognitive Emotion Regulation Questionnaire cell microarray (CERQ) central Asia cognitive processing therapy Central European encephalitis coinfection central nervous system Lyme disease cold panniculitis central collapsing glomerulopathy cercarial dermatitis colon capsule endoscopy cerebral schistosomiasis compression ultrasonography Emtree Terms Changed in May 2021 7 computed tomographic venography Cruveilhier-Baumgarten syndrome computed tomography aortography cryptogenic ischemic stroke computed tomography pulmonary CSF signaling angiography cubic crystal conditioning (psychology) Cumulative Illness Rating Scale congenital long QT syndrome CURB-65 score conjunctival scissors curfew conjunctival trocar cutaneous leishmaniasis connexon cycle threshold value content uniformity cytokine signaling continuous electroencephalography cytometric bead array continuous training cytophagic histiocytic panniculitis convalescent plasma therapy data availability convalescent plasma transfusion data privacy COPE inventory data protection Copenhagen Psychosocial Questionnaire de Jong Gierveld Loneliness Scale Coping Style Questionnaire delayed cord clamping copper test kit dental insurance copyright infringement dental light cordectomy Depression, Anxiety and Stress Scale cordon sanitaire Depression, Anxiety and Stress Scale-21 cordotomy (spinal cord) Depression, Anxiety and Stress Scale-42 corneal endotheliitis dew point temperature coronal suture diabetes management software coronary artery clamp diagnosis time coronavirus HKU1 infection diethylnitrosamine-induced correctional staff hepatocarcinogenesis correspondence course differentiation syndrome cost inflation diffuse cutaneous leishmaniasis cough stress test dilute Russel viper venom time counter current chromatograph direct laryngoscopy COVID Stress Scales disability insurance COVID toe disaster management COVID-19 Anxiety Scale disaster mitigation COVID-19 related psychological distress disaster preparedness COVID-19 Severity score disaster recovery COVID-19 skin manifestation disaster response COVID-19-associated acute hemorrhagic disinfestation robot necrotizing encephalopathy dispenser COVID-19-associated nephropathy disseminated cutaneous leishmaniasis COVID-GRAM Critical Illness Risk Score distal radius prosthesis CRB-65 score distance learning crispness distribution uniformity critical illness myopathy diurnal temperature range critical illness polyneuromyopathy DNA methylation age critical illness polyneuropathy door-to-balloon time cross priming amplification drug induced cholestasis Crotalus scutulatus drug induced hepatitis crunchiness drug-induced liver injury Emtree Terms Changed in May 2021 8 dry bulb temperature estrogen signaling dysexecutive syndrome etioplast Dysfunctional Beliefs and Attitudes about Exiguobacterium sibiricum Sleep scale expedited partner therapy early cord clamping experimental autoimmune uveitis ECOG Performance Status experimental hemolytic anemia economic well-being experimental myopia effective reproduction number extracellular acidification rate EGFR signaling extracellular signaling egg powder extravascular lung water index elaioplast eyeblink conditioning elaiosome eyelid scissors electrochemiluminescence immunoassay fascin test kit electronic consultation fast protein liquid chromatography column electrophoresis analyzer Fear-Avoidance Beliefs Questionnaire electrophoresis equipment fecal fat test kit element test kit female fertility marker test kit embezzlement Female Sexual Distress Scale embryologist fiberoptic tracheal intubation emergency evacuation Fibrosis-4 Index Emotion Regulation Questionnaire (ERQ) finger prosthesis emotional well-being finger protector encephalitis lethargica first person shooter game encryption fish sauce endocrine signaling fitness center endoscopic hemostasis Fitz-Hugh-Curtis syndrome endoscopic laser cordectomy flame ionization detector endoscopic laser therapy borne disease endoscopic pituitary surgery flea borne spotted fever endoscopic variceal ligation flexible fiberoptic laryngoscopy endosomal pH flexible laryngoscopy endotheliitis flexible nasal endoscopy engraving Flinders Island spotted fever enterically transmitted hepatitis flow-FISH entertainment industry fluid-attenuated inversion recovery imaging enzootic disease fluorescence wound imaging system enzootic pneumonia fluorouracil-resistant cell line enzymatic interesterification fly borne disease enzyme test kit folate deficiency anemia eosinophilic asthma food dispenser Eph/ephrin signaling food legislation epicarditis food reinforcement epidemic doubling time food robot epigenetic clock foot paralysis epithelioid histiocyte fraction of inspired oxygen Epstein Barr virus hepatitis fracturability equine encephalitis fulminant hepatitis error proofing fulminant myocarditis erythrocytapheresis fulminant viral hepatitis Emtree Terms Changed in May 2021 9 fungal zoonosis hepatitis D G-CSF signaling herpes simplex 1 encephalitis GABAergic signaling herpes simplex 2 encephalitis gabapentin therapeutic drug test kit herpes simplex virus hepatitis gas liquid chromatograph hexagonal crystal gas solid chromatograph high grade inflammation gasless laparoscopy high intensity exercise GBM2 cell line high performance liquid chromatograph gel filtration chromatography column high performance liquid chromatography gel permeation chromatography column column General Health Questionnaire-12 high pressure injection injury General Health Questionnaire-28 hilar lymphadenopathy General Health Questionnaire-30 HK cell line (hairy cell leukemia) General Health Questionnaire-60 Horowitz index General Self-Efficacy Scale Hospital Anxiety and Depression Scale- Generalized Anxiety Disorder Scale Anxiety Generalized Anxiety Disorder-2 Hospital Anxiety and Depression Scale- Generalized Anxiety Disorder-7 Depression Geriatric Nutritional Risk Index host-directed therapy gerontoplast hotel staff giant cell hepatitis Human coronavirus HKU1 global rating of change scale human Global Severity Index human herpesvirus 6 infection glutamatergic signaling hydrophilic interaction chromatography glutamatergic transmission column glycan array hydrophobic interaction chromatography GM-CSF signaling column goblet cell metaplasia hypercapnic respiratory failure gold mining hyperproteinorrhachia GPCR signaling hypoglycorrhachia graduate education hypovolemic hyponatremia granulocyte and monocyte adsorption hypoxemic respiratory failure apheresis IL 1 signaling granulocyte apheresis IL 2 signaling gumminess IL 3 signaling gymnastics IL 4 signaling hand brace IL 5 signaling hand paralysis IL 6 signaling hand swelling Illness Perception Questionnaire Health Anxiety Inventory Illness Perception Questionnaire-Revised health legislation immobilized metal affinity chromatography health savings account column Healthcare Access and Quality Index immune signaling Hearing Handicap Inventory for Adults immunoaffinity chromatography column Hearing Handicap Inventory for the Elderly immunofluorescence assay helmet immunoglobulin test kit hemadsorption inhibition tests immunomagnetic cell separation hemicraniectomy immunosignature hemorrhagic encephalopathy implantation window Emtree Terms Changed in May 2021 10 in situ polymerase chain reaction labor law in-hospital mortality lacrimal cannula Indian spotted fever lactase test kit indirect laryngoscopy lactoferrin test kit infant behavior questionnaire lambdoid suture Infant Behavior Questionnaire-Revised laparoscopic appendectomy infection fatality rate large vessel vasculitis infection fatality ratio laryngotracheal reconstruction infectious inflammation laser cordectomy inferior mesenteric artery thrombosis laser therapy inflation (economics) latent infection inflation pressure lateral flow immunochromatography inherited arrhythmia syndrome lead diagnostic kit injection injury lean methodology instant coffee lean six sigma instant food left atrial function instant noodle left lateral ventricle intensive care medicine leg paralysis intercellular signaling Leishmania infantum cutaneous interferon signaling leishmaniasis interleukin signaling Leishmania infantum infection intermittent hypoxic training Leishmania infantum visceral leishmaniasis intermittent lockdown Leonotis interstitial syndrome Leonotis leonurus interval training Leonotis nepetifolia intestinal schistosomiasis leucoplast intracrine signaling leukoreduction inverse gas chromatograph liability insurance invertebrate photoreceptor life insurance ion exchange chromatography column ligneous conjunctivitis ischemic hepatitis limb paralysis ischemic shock lip swelling ischemic stroke lipid signaling isothermal amplification liquid chromatography column Israeli spotted fever liquid chromatography-mass spectrometer Japanese Orthopedic Association score liquid permeable film dressing JNK signaling Lissachatina journalism liver and kidney function test juiciness localized cutaneous leishmaniasis juxtacrine signaling lockdown exit strategy K562(S) cell line Lotus tetragonolobus keratinocyte carcinoma louse borne disease Kessler psychological distress scale louse borne relapsing fever Kessler Psychological Distress Scale (K10) low density lipoprotein apheresis Kessler Psychological Distress Scale (K6) low grade inflammation kidney organoid low intensity exercise KKU-213A cell line low-dose computed tomography KKU-213B cell line low-dose radiotherapy KKU-M213C cell line lower limb paralysis Emtree Terms Changed in May 2021 11 lung ultrasound score Mini-Nutritional Assessment Short-Form lupus hepatitis mirror therapy lupus panniculitis MMORPG (game) Lyme carditis MOBA (game) lymphocytapheresis mobile learning lymphocytic myocarditis moderate intensity continuous training lysosomal pH moderate intensity exercise M-CSF signaling modified Borg dyspnea scale macrosteatosis Modified Early Warning Score macrovesicular steatosis molecular biologist magnetic immunoassay monoclinic crystal Major Depression Inventory monoclonal antibody therapy Mallampati score monocyte apheresis malnutrition assessment Morningness-Eveningness Questionnaire mammalian chromosome morpheaform basal cell carcinoma manufacturing mosquito borne disease MAR-FISH mosquito borne encephalitis Maruca mouthfeel Maruca vitrata mucus plugging mass fragmentograph Muellerian inhibiting factor test kit massive hepatic necrosis Multidimensional Scale of Perceived Social massive intracerebral hemorrhage Support mast cell activation syndrome multifetal pregnancy reduction Maudsley Obsessive-Compulsive Inventory Multiple Sclerosis Quality of Life-54 mayonnaise Munich ChronoType Questionnaire MDS-Unified Parkinson Disease Rating Scale myopericarditis medical device related pressure ulcer NAFLD Fibrosis Score medical robot nasal endoscopy melatonin test kit nasal stent menstrual cycle length nasopharyngeal sampler mesenchymal stromal cell therapy nasopharyngoscopy mesenteric artery thrombosis National Early Warning Score mesenteric panniculitis National Early Warning Score 2 mesenteric thrombosis national lockdown metabolic fatty liver natural killer cell count metabolite test kit necroinflammation metastatic castration resistant prostate necrolytic acral erythema cancer negative reinforcement metastatic castration sensitive prostate serogroup A cancer Neisseria meningitidis serogroup B metopic suture Neisseria meningitidis serogroup C microautoradiography nematode zoonosis microsteatosis neoplastic cell transformation microvascular thrombosis neoplastic fever microvesicular steatosis neutrophilic inflammation Middle East respiratory syndrome New World cutaneous leishmaniasis coronavirus (strain Hu/Jordan-N3/2012) New World leishmaniasis Mindful Attention Awareness Scale New World visceral leishmaniasis Mini-Nutritional Assessment NF kB signaling Emtree Terms Changed in May 2021 12 nipple-sparing mastectomy paper chromatograph nitrergic neurotransmission papillary renal cell carcinoma nocturnal oxygen therapy parasitic zoonosis non transfusion dependent thalassemia parenchymal lesion non-canonical Wnt signaling Parenting Stress Index non-cirrhotic portal fibrosis Parenting Stress Index-Short Form non-cirrhotic portal hypertension paroxysmal nocturnal dyspnea noodle Parrot's pseudoparalysis noradrenergic transmission partial glossectomy normal weight obesity partial lockdown northern Asia participatory medicine Nrf2 signaling passage number NTRK test kit passive immunotherapy nucleic acid microarray patient engagement nucleic acid purification robot Patient Health Questionnaire 4 nurse robot pediatric dentistry Nursing Delirium Screening Scale penile splint Nutritional Risk Index penis clip obesity associated inflammation Penn State Worry Questionnaire obesity related glomerulopathy peptide microarray obstructive lung disease peptide receptor radionuclide therapy obstructive pneumonia persistent inflammation, ocean circulation immunosuppression and catabolism Okinawan diet syndrome Old World cutaneus leishmaniasis phacovitrectomy Old World leishmaniasis pharmacy education Old World visceral leishmaniasis pharyngeal edema Oldenburg Burnout Inventory pharyngoscopy olfactory neuritis phenotype microarray online game physiological adaptation open source software phytodegradation operant conditioning phytoextraction oral potentially malignant disorder phytostabilization oral sampler phytovolatilization organizational decision making pituitary surgery orthodontic tube plagiarism orthorhombic crystal planar cell polarity signaling orthotic insole plastoglobule osteoconductive cage platypnea orthodeoxia syndrome out-of-hospital mortality Pluchea outdoor delivery robot Pluchea indica ovarian vein thrombosis Pluchea lanceolata pneumonic plague p53 signaling podcast Padua Prediction Score polysyndactyly paleobiology porcine deltacoronavirus infection paleobotany portal fibrosis paleogenetics positive reinforcement paleovirology Positive symptom distress index Emtree Terms Changed in May 2021 13

Positive symptom total purinergic transmission positivity rate pyrenoid Post-COVID-19 Functional Status scale pyrolysis gas chromatograph postaxial polydactyly Q-FISH postencephalitic parkinsonism quantitative buffy coat postmortem computed tomography Queensland tick postoperative swelling quick Sequential Organ Failure Assessment postoperative vasoplegia Score postpneumonectomy syndrome quorum quenching Posttraumatic Growth Inventory radiation induced bystander effect posttraumatic stress disorder checklist radioactive air pollution posttraumatic stress disorder checklist- radioactive water pollution civilian version radiology robot posttraumatic stress disorder checklist- RANKL signaling military version Rapid Emergency Medicine Score posttraumatic stress disorder checklist- receptionist robot specific receptive music therapy power training recombinase polymerase amplification PPAR signaling redox signaling preaxial polydactyly Reflux Symptom Index preemptive antiviral therapy reinforcement (psychology) preemptive therapy relapsing fever preoperative endocrine prognostic index relative humidity prevalence ratio RESP score primary education reticular opacity processed fruit retrograde urethrography professional well-being reverse phase protein microarray prognostic nutritional index reverse transcription recombinase proplastid polymerase amplification proprietary software reversed phase liquid chromatography protein Z test kit column proteinoplast Rheumatic Disease Comorbidity Index protozoan zoonosis Rhinocladiella pseudomembranous conjunctivitis pseudoparalysis Rhizobium leguminosarum bv. trifolii pseudoparalytic Rhizobium leguminosarum bv. viciae psychiatric complication Rhizobium sp. NGR234 psychological counseling rhizodegradation psychological extinction Rhodococcus jostii RHA1 psychological practice rhombencephalitis puerperal fever rhombohedral crystal puerperal sepsis rickettsial pneumonia pulmonary artery thrombosis rickettsial zoonosis Pulmonary Embolism Severity Index right atrial function pulmonary intravascular coagulopathy right lateral ventricle pulmonary thrombosis rigid laryngoscopy pulmonary vein thrombosis rigid nasal endoscopy pungency RNA microarray purinergic signaling robbery Emtree Terms Changed in May 2021 14 robot serving robot robotic ultrasound severe asthma Ross River virus infection sexual well-being Russian spring summer encephalitis shelter-in-place saddle nose shoplifting sagittal suture short health anxiety inventory salad dressing Short Warwick-Edinburgh Mental Well-Being salivary gland infection Scale Samia short-course radiotherapy Samia cynthia silver in situ hybridization SARC-F questionnaire Simmondsia SARS-CoV-2 (clinical isolate Simmondsia chinensis betaCoV/KOR/KCDC03/2020) Simmondsiaceae SARS-CoV-2 (clinical isolate Brazil) simplified coping style questionnaire SARS-CoV-2 (clinical isolate Germany/291.3 single nucleotide polymorphism array FR-4286) six sigma methodology SARS-CoV-2 (clinical isolate hCoV- skin treatment garment 19/Norway/Trondheim-S15/2020) skin-reducing mastectomy SARS-CoV-2 (isolate hCoV-19/Egypt/NRC- skin-sparing mastectomy 3/2020) Smad signaling SARS-CoV-2 (strain hCoV- small scale gold mining 19/Spain/VH000001133/2020) snoezelen SARS-CoV-2 (strain JPN/TY/WK-521) social cohesion SARS-CoV-2 (strain Russia/RP/2020) social connectedness SARS-CoV-2 lineage P.3 social reinforcement SARS-CoV-2 variant 20-C Social Support Rating Scale SARS-Cov-2 variant 20J/501Y.V3 Social Vulnerability Index SARS-Cov-2 variant 501Y.V1 social well-being SARS-CoV-2 variant 501Y.V2 solitary confinement SARS-CoV-2 variant CAL.20C solution-focused therapy SARS-CoV-2 variant VUI-202102/03 sonourethrography SARS-CoV-2 variant VUI-202102/04 soy sauce SARS-CoV-2 virus (hCoV-19/Taiwan/4/2020) spinal cord schistosomiasis sauce spinal subdural hematoma spiritual well-being sclerosing mesenteritis splanchnic vein thrombosis secondary education sport facility secondary parkinsonism spotted fever Self Reporting Questionnaire 20 sprint interval training Self-Compassion Scale sputum induction sensitive personal information stay-at-home order septicemic plague steatohepatitis septoplasty stem cell apheresis serial interval sterile inflammation Seriola stopwatch Seriola quinqueradiata strategic reserve serological surveillance Strongylocentrotus droebachiensis serositis subacute ischemic stroke service robot subcutaneous fat necrosis Emtree Terms Changed in May 2021 15 subcutaneous fat necrosis of the newborn substrate reduction therapy Tubifex superior mesenteric artery thrombosis Tubifex tubifex supine empty stress test Tubificina suppurative parotitis turbinoplasty suppurative sialadenitis TWEAK signaling supraglottoplasty type I interferon signaling surgical hemostasis type II interferon signaling symbrachydactyly type III interferon signaling Symptom Checklist 90-Revised ultrasound stethoscope Synechococcus elongatus PCC 7942 ultraviolet germicidal irradiation systemic signaling umbilical cord clamping TCR signaling umbilical cord mesenchymal stem cell teledentistry transplantation telemedicine robot undergraduate education telenephrology uniformity of dosage teleneurology unilateral salpingo-oophorectomy telepharmacy unipolar hemiarthroplasty telepsychology upper limb orthosis telepsychotherapy upper limb paralysis telogen effluvium uranium mining Templer Death Anxiety Scale vaginal brachytherapy tertiary education vaginal illumination device tetragonal crystal vaginoscopy thermal water pollution value stream mapping thin-section computed tomography valve-in-valve transcatheter aortic valve thromboinflammation implantation tick borne relapsing fever vaping associated lung injury Tinnitus Handicap Inventory vascular parkinsonism tissue embedding device vasodilatory shock TNF signaling vending machine tomato sauce ventilator associated bacterial pneumonia tonsillar squamous cell carcinoma verbal reinforcement total glossectomy vertebrate photoreceptor Townsend deprivation index vesicle trafficking tracheal extubation veterinary education transfection cell microarray video consultation transferrin saturation videofluorography transfusion dependent thalassemia videolaryngoscopy transient tachycardia viral rash translabyrinthine approach viral zoonosis transoral robotic surgery virologist transverse myelitis virtual microscopy trauma-focused cognitive behavioral therapy visual management travel restriction visual pattern recognition trematode zoonosis vitamin E test kit Treponema pallidum subsp. pertenue vitamin K test kit Treponema phagedenis vitamin test kit triclinic crystal vlogging Emtree Terms Changed in May 2021 16 vulvoscopy WHOQOL-100 wake up stroke WHOQOL-BREF Warwick-Edinburgh Mental Well-being Scale Wnt/calcium signaling weight training Work and Social Adjustment Scale weight uniformity work from home wellness center wristwatch western Asia Xanthomonas campestris pv. campestris wet bulb temperature Yo antibody test kit white lung zoonotic dermatophytosis WHO-5 Well-Being Index Zung Self Rating Anxiety Scale Emtree Terms Changed in May 2021 17

Drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new rm 2 hydroxyoleic acid te 2-hydroxyoleic acid abdavomeran* bnt162b1 ad5 ncov vaccine ad5 ncov 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) (4 adezmapimod 5 pyridyl)imidazole alvocidib flavopiridol baculoviral IAP repeat containing protein 1 neuronal apoptosis inhibitory protein baculoviral IAP repeat containing protein 3* inhibitor of apoptosis protein 2 baculoviral IAP repeat containing protein 5 survivin bnt 162 vaccine bnt162 buzhong yiqi buzhong yiqi tang casirivimab* regn10933 casirivimab plus imdevimab regn-cov2 cilgavimab* azd1061 cilgavimab plus tixagevimab azd7442 cm 101 (bacterial toxin) cm 101 delandistrogene moxeparvovec srp 9001 dimethyl fumarate fumaric acid dimethyl ester dimethyl fumarate plus monoethyl fumarate fumaderm dirloctocogene samoparvovec* efineptakin spk 8011 alfa* hyleukin 7 exagamglogene autotemcel ctx001 imdevimab* regn10987 inetagugene geperpavec kb 105 isaralgagene civaparvovec st 920 ledelabricin alfa rulabricin alfa liuwei dihuang liuweidihuang tang monoethyl fumarate fumaric acid ethyl ester ordesekimab amg 714 peboctocogene camaparvovec sapropterin* bay 2599023 sesiclenegene cosaparvovec tetrahydrobiopterin temgicoluril at gtx 501 tifcemalimab mebicar tixagevimab* icatolimab tozinameran* azd8895 transcrocetin bnt162b2 valiloxybate crocetin vanglusagene ensiparvovec verbrinacogene valiloxibic acid setparvovec* spk 3006 flt180a Emtree Terms Changed in May 2021 18

Non-drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new te rm autocrine signaling autocrine effect autoimmune hepatitis* lupoid hepatitis bone marrow mesenchymal stem cell bone marrow derived mesenchymal stem cel lateral l brain lateral ventricle* brain ventricle bystander effect (cell) bystander effect cervicotomy cervicectomy chronic infection persistent infection CL1-1 cell line (lung adenocarcinoma) CL1-1 cell line CL1-3 cell line CL13 cell line coinfection concurrent infection coinfection mixed infection cordotomy (spinal cord) cordotomy cranial suture* skull suture cutaneous leishmaniasis skin leishmaniasis dental light LED dental light Depression, Anxiety and Stress Scale Depression Anxiety Stress Scale differentiation syndrome retinoic acid syndrome epithelioid histiocyte epithelioid cell GBM2 cell line GBM-2 cell line halopelvic traction device* halo-pelvic traction device helmet protective helmet hepatitis D delta agent hepatitis Histoplasma* Ajellomyces HK cell line (hairy cell leukemia) HK cell line immunofluorescence assay fluoroimmunoassay immunofluorescence assay immunofluorescence test Japanese Orthopedic Association score Japanese Orthopaedic Association score K562(S) cell line K-562S cell line KKU-213A cell line KKU-M213 cell line KKU-213B cell line KKU-M214 cell line KKU-M213C cell line KKU-M156 cell line microvascular thrombosis microthrombus neuroborreliosis* Lyme neuroborreliosis open ended questionnaire* open-ended questionnaire operant conditioning instrumental conditioning reinforcement (psychology) reinforcement rhinoplasty nose reconstruction septoplasty nose septum reconstruction uranium mining uranium mine