Auscultation While Standing: a Basic and Reliable Method to Rule out a Pathologic Heart Murmur in Children
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Auscultation While Standing: A Basic and Reliable Method to Rule Out a Pathologic Heart Murmur in Children 1,2,3 Bruno Lefort, MD ABSTRACT 1 Elodie Cheyssac, MD PURPOSE The distinction between physiologic (innocent) and pathologic Nathalie Soulé, MD1 (organic) heart murmurs is not always easy in routine practice, leading too often to unnecessary cardiology referrals and expensive investigations. We aimed to 1 Jacques Poinsot, MD test the hypothesis that the complete disappearance of murmur on standing can Marie-Catherine Vaillant, MD1 exclude cardiac disease in children. Alaeddin Nassimi MD4 METHODS From January 2014 to January 2015, we prospectively included 194 1,2 consecutive children aged 2 to 18 years who were referred for heart murmur Alain Chantepie, MD, PhD evaluation to pediatric cardiologists at 2 French medical centers. Heart murmur 1Children Hospital Gatien de Clocheville, characteristics while supine and then while standing were recorded, and an echo- University Hospital Centre of Tours, Tours, cardiogram was performed. France RESULTS Overall, 30 (15%) of the 194 children had a pathologic heart murmur 2University François Rabelais, Tours, France as determined by an abnormal echocardiogram. Among the 100 children (51%) 3INSERM UMR 1069 - Nutrition, Crois- who had a murmur that was present while they were supine but completely dis- sance et Cancer, Tours, France appeared when they stood up, only 2 had a pathologic murmur, and just 1 of 4University Hospital Centre of Poitiers, them needed further evaluation. Complete disappearance of the heart murmur Poitiers, France on standing therefore excluded a pathologic murmur with a high positive predic- tive value of 98% and specificity of 93%, albeit with a lower sensitivity of 60%. CONCLUSIONS Disappearance of a heart murmur on standing is a reliable clini- cal tool for ruling out pathologic heart murmurs in children aged 2 years and older. This basic clinical assessment would avoid many unnecessary referrals to cardiologists. Ann Fam Med 2017;15:523-528. https://doi.org/10.1370/afm.2105. INTRODUCTION eart murmur is a clinical finding currently affecting about 65% to 80% of schoolchildren1,2 and one of the most common reasons Hfor referral to cardiologists. Most murmurs are physiologic (inno- cent)3 and result from the normal pattern of blood flow through the car- diac cavities and vessels. In a few cases, however, the murmur may be the single symptom of cardiac disease, even if most congenital heart diseases are diagnosed before birth or during the first year of life.1 Differences between physiologic and pathologic murmurs are well Annals Journal Club selection; known,4-9 but primary care physicians in family medicine or pediatricians see inside back cover or http://www.annfa- too frequently refer their patients to pediatric cardiologists because they mmed.org/AJC/. fear missing a heart disease diagnosis, resulting in unneeded parental anxiety, time consumption, and expensive evaluations.10,11 Several clinical Conflicts of interest: authors report none. features of the murmur such as intensity, timing, quality and pitch, and the presence of a click are subjective and require extensive training for use to distinguish between physiologic and pathologic murmur. A simple, CORRESPONDING AUTHOR objective, and robust clinical test to exclude cardiac disease in apparently Bruno Lefort, MD healthy children could prevent many unnecessary referrals. Children Hospital Gatien de Clocheville McLaren et al12 reported that the prevalence of physiologic heart University Hospital Centre of Tours 49 Bd Béranger murmur in schoolchildren was 65% when they were in a supine position, 37044 Tours Cedex 01, France whereas it was only 15% when they were standing. To our knowledge, [email protected] however, no study has demonstrated that the disappearance of murmur ANNALS OF FAMILY MEDICINE ✦ WWW.ANNFAMMED.ORG ✦ VOL. 15, NO. 6 ✦ NOVEMBER/DECEMBER 2017 ANNALS OF FAMILY MEDICINE ✦ WWW.ANNFAMMED.ORG ✦ VOL. 15, NO. 6 ✦ NOVEMBER/DECEMBER 2017 PB 523 AUSCULTATION WHILE STANDING on standing can allow clinicians to rule out a murmur the included children provided their informed consent, generated by underlying pathology. In this study, we and the Ethics Committee for Human Research of the aimed to test the disappearance of heart murmur in Tours Hospital approved the study. We excluded chil- standing children, aged 2 years and older, as a reliable dren aged younger than 2 years, those who could not test to exclude pathologic murmur. stand for at least 1 minute, and those who had already been examined by a cardiologist or pediatric cardiolo- gist, or who had already had an echocardiogram. METHODS Six pediatric cardiologists participated in the Between January 2014 and January 2015, we prospec- study. They collected the child’s personal history of tively included in our study 194 consecutive children cardiopulmonary symptoms: dyspnea at rest or during referred to pediatric cardiologists at 2 French univer- exercise, palpitations, syncope, and failure to thrive or sity hospital centers (156 referred to Tours Medical grow. They also noted the characteristics of heart aus- Center, 38 referred to Poitiers Medical Center) for cultation with an acoustic-based, nonelectronic stetho- evaluation of heart murmur. Children with genetic or scope, first with the patient in the supine position, systemic disorders or a family history of heart disease and then for at least 1 minute in the standing position: were excluded, as these findings on their own are suf- presence or absence of the murmur, timing (systolic, ficient to prompt referral to a specialist. All parents of diastolic, both, continuous), location of maximal Table 1. Clinical and Echocardiographic Characteristics of the 30 Children With Abnormal Findings on an Echocardiogram Murmur Reduction of Age, While Intensity While Patient Sex y Standing Standing Location Radiation Timing Symptoms Cardiac Disease Patient 1 M 12 No NA Low to middle left sternal border No Systolic No Muscular VSD Patient 2 F 13 No NA Left upper sternal border No Systolic No ASD OS Patient 3 M 7 Yes No Left upper sternal border No Systolic Yes ASD OS Patient 4 F 10 Yes No Apex Yes Systolic No Mitral regurgitation Patient 5 F 6 Yes No Apex No Systolic No Mitral regurgitation Patient 6 F 5 Yes Yes Left upper sternal border No Systolic No ASD OS Patient 7 F 10 Yes Yes Low to middle left sternal border No Systolic Yes Mitral regurgitation Patient 8 F 13 Yes Yes Low to middle left sternal border No Systolic No Mitral regurgitation Patient 9 F 5 Yes No Low to middle left sternal border Yes Systolic No Aortic stenosis Patient 10 F 5 Yes Yes Left upper sternal border No Systolic No ASD OS Patient 11 F 8 Yes No Left upper sternal border No Systolic No ASD OP Patient 12 F 13 Yes Yes Left upper sternal border No Systolic No Pulmonary stenosis Patient 13 F 5 Yes No Apex No Systolic No Mitral regurgitation Patient 14 F 6 Yes Yes Low to middle left sternal border No Systolic No Coronary-to–pulmonary artery fistula Patient 15 M 9 Yes No Low to middle left sternal border No Systolic No Perimembranous VSD Patient 16 M 2 Yes No Low to middle left sternal border No Systolic Yes Muscular VSD Patient 17 M 4 Yes No Low to middle left sternal border No Systolic No Muscular VSD Patient 18 M 9 Yes Yes Low to middle left sternal border Yes Systolic Yes Muscular VSD, ASD OS Patient 19 M 4 Yes Yes Low to middle left sternal border No Systolic Yes Muscular VSD Patient 20 M 12 Yes Yes Low to middle left sternal border Yes Systolic No Tricuspid regurgitation Patient 21 M 6 Yes No Low to middle left sternal border No Systolic No Mitral regurgitation Patient 22 M 2 Yes Yes Low to middle left sternal border Yes Systolic No Coarctation of aorta Patient 23 M 6 Yes No Right upper sternal border Yes Systolic No Mitral regurgitation Patient 24 M 10 Yes No Right upper sternal border Yes Systolic No Aortic stenosis Patient 25 M 3 Yes No Left upper sternal border Yes Systolic No ASD OS Patient 26 M 5 Yes Yes Right upper sternal border Yes Systolic No Aortic stenosis Patient 27 M 2 Yes No Left upper sternal border No Systolic Yes ASD OP Patient 28 M 13 Yes Yes Left upper sternal border No Systolic No ASD OP Patient 29 M 4 Yes No Left upper sternal border No Systolic Yes ASD OS Patient 30 F 2 Yes Yes Under left clavicle Yes Continuous No PDA ASD = atrial septal defect; F = female; M = male; NA = not applicable; OP = ostium primum; OS = ostium secundum; PDA = patent ductus arteriosus; VSD = ventricular septal defect. ANNALS OF FAMILY MEDICINE ✦ WWW.ANNFAMMED.ORG ✦ VOL. 15, NO. 6 ✦ NOVEMBER/DECEMBER 2017 524 AUSCULTATION WHILE STANDING intensity (right upper sternal border, left upper sternal data. Analyses were performed using Prism version 5 border, low to middle left sternal border, under left (GraphPad Software, Inc). Statistical significance was clavicle, apex, back), and radiation (yes, no). Changes defined as aP <.05. in intensity (higher, lower, or comparable) between supine and standing positions were also evaluated when a murmur was present in both positions. After RESULTS this physical examination had been completed, all chil- Among the 194 children studied, 30 (15%) had abnor- dren then had an echocardiogram to assess the pres- mal findings on echocardiogram that explained the ence or absence of cardiac anomalies that could explain murmur. The cardiac diseases diagnosed were atrial the murmur. Trivial valvular regurgitations and patent septal defects (ASDs) in 9 children, ventricular septal foramen ovale were considered to be physiologic and defects (VSDs) in 5, ASD associated with VSD in 1, not to explain the murmur. sonographically important mitral regurgitation in 7, Descriptive data are presented as means ± stan- tricuspid regurgitation in 1, aortic valve stenosis in dard deviations, and diagnostic performance data are 3, pulmonary valve stenosis in 1, coarctation of the presented as values with 95% confidence intervals.