Th eJournal of Immunology VOLUME 196, NUMBER 7 • APRIL 1, 2016 • WWW.JIMMUNOL.ORG

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IMMUNOLOGYPROGRAM ISSUE2016 IMMUNOLOGY 2016 ™

PROGRAM PREVIEW

The American Association of Immunologists AAI Annual Meeting May 13–17, 2016 | Seattle, Washington Washington State Convention Center The American Association of Immunologists Career Award Recipients for 2016 The American Association of Immunologists proudly announces the 2016 recipients of AAI awards for outstanding research and career achievements. The 2016 AAI award winners will be recognized at IMMUNOLOGY 2016™ May 13–17, Seattle, Washington.

AAI Lifetime AAI Distinguished Achievement Award Service Award In recognition of a career For outstanding service to AAI of scientific achievement and and the immunology community contributions to AAI and as the AAI Secretary-Treasurer fellow immunologists for two terms, 2009–2015

Olivera J. Finn, Ph.D. Mitchell Kronenberg, Ph.D. University of Pittsburgh School of Medicine La Jolla Institute for Allergy & Immunology

AAI-Steinman Award for AAI-BioLegend AAI-Thermo Fisher Human Immunology Research Herzenberg Award Meritorious Career Award For significant, For outstanding For outstanding sustained research research achievement in contributions contributions immunology to the field to the field research pertinent of immunology of immunology to human disease pathogenesis, in the area prevention, or of B cell biology therapy Lieping Chen, M.D., Ph.D.
John F. Kearney, Ph.D. Kenneth M. Murphy, M.D., Ph.D. Yale School of Medicine University of Alabama, Birmingham HHMI, Washington University School of Medicine

AAI-BD Biosciences AAI Excellence Investigator Award in Mentoring Award For outstanding, early-career In recognition of exemplary research contributions career contributions to a future to the field of immunology generation of scientists

Ming Li, Ph.D. Richard A. Flavell, Ph.D. Memorial Sloan Kettering Cancer Center HHMI, Yale School of Medicine and Cornell University www.IMMUNOLOGY2016.org PROGRAM PREVIEW IMMUNOLOGY 2016 ™

AAI PRESIDENT’S PROGRAM

AAI President’s Address FRIDAY, MAY 13, 5:00 PM Washington State Convention Center, Ballroom 6BC Dan R. Littman HHMI, New York University School of Medicine, AAI President From the thymus to the mucosa: a three-decade journey

Arthur Weiss , HHMI, University of California, San Francisco Dan R. Littman Introduction

AAI President’s Symposium: Host Immune Responses to Viruses MONDAY, MAY 16, 12:30 PM – 2:30 PM Washington State Convention Center, Ballroom 6BC Chair: Dan R. Littman, HHMI, New York University School of Medicine, AAI President Speakers: Adolfo Akiko Iwasaki Garcia-Sastre Adolfo Garcia-Sastre, Mount Sinai School of Medicine Regulation of innate immune pathways during RNA virus infections Akiko Iwasaki, HHMI, Yale School of Medicine Antiviral immune responses at mucosal surfaces Louis J. Picker, Oregon Health & Science University CD8+ T cell recognition of cytomegalovirus: who is in charge? E. John Wherry, University of Pennsylvania Development and reversal of T cell exhaustion Louis J. Picker E. John Wherry

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI President’s Symposium Adolfo Garcia-Sastre is a consummate virologist and one of the leading authorities on infl uenza virus. His studies have led to an understanding of how diverse negative strand RNA viruses evade host innate immune responses and provided key insights toward developing better vaccines. His laboratory pioneered approaches to generate recombinant infl uenza viruses which led to major breakthroughs in revealing the molecular basis of infl uenza virus pathogenicity.

Akiko Iwasaki studies how viruses interact with the host immune system at mucosal surfaces. She has studied immune responses to herpes simplex viruses in the genital tract and to infl uenza virus infection in the lung. Her laboratory has characterized the role of pattern recognition Dan R. Littman receptors and of autophagy in antiviral responses and AAI President host tolerance to virus-induced damage. Her research also has revealed the mechanism by which mucosal dendritic cells prime virus-specifi c T cell responses. Akiko’s recent innovative work on developing mucosal vaccines that elicit t has been a privilege to serve the immunology resident memory T cells holds great promise. Icommunity during my years as an AAI Council member and offi cer. It is a particular pleasure to organize the Louis Picker studies antiviral effector and memory T President’s Symposium for this year’s annual meeting - a cell responses in humans and non-human primates. His milestone meeting being the 100th!* I have chosen a theme group has developed approaches to elicit lasting antiviral that remains dear to my heart. While I was a postdoctoral immunity against pathogenic SIV and has studied the fellow working on cloning genes encoding T cell surface potential of CMV vectors for this purpose. They have molecules, the AIDS epidemic struck, and it quickly investigated the properties of CMV genes in priming T cell became clear that the virus attacks T helper cells. Because responses in macaques and shown that they can use CMV of my work on CD4, called T4 at that time, the mechanism vectors to generate diverse T cell responses, including CD8 of viral entry became a major focus of my new laboratory. T cells specifi c for primate lentiviral antigens presented by MHC-II and MHC-E. These advances have provided In the 20 years since the discovery of CCR5 as the major valuable insights for developing effective HIV vaccines. “co-receptor” required for HIV entry, awareness has grown of the importance of diverse innate signaling pathways Investigation of antiviral T cell responses has provided in protecting the host from pathogenic viruses, and invaluable insights into mechanisms of tumor-specifi c our interest has shifted toward elucidating the roles of immunity. John Wherry has been a key contributor in dendritic cells in HIV pathogenesis. At the same time, it this area. His early studies of CD8 T cell responses to has become increasingly clear that development of an HIV LCMV revealed the phenomenon of “T cell exhaustion” vaccine would be a monumental task requiring a much and the role of inhibitory receptors such as PD-1 in this better understanding of how both adaptive and innate process. Wherry’s ongoing studies on the molecular and immune system components interact with the virus and epigenetic underpinning of T cell exhaustion are relevant its products. Although progress in this area has been slow, for developing both antiviral and antitumor therapies. there have been very encouraging advances during the past few years, and there is renewed hope that effective * AAI canceled three successive annual meetings (1943-1945) vaccines will be developed. because of travel restrictions imposed during World War II.

I have chosen to highlight some of the recent exciting work in virus-host interactions by inviting four investigators who are doing pioneering work on diverse viruses and their interactions with innate and adaptive branches of the immune system.

www.IMMUNOLOGY2016.org AAI LECTURES AND AWARD PRESENTATIONS

AAI DISTINGUISHED LECTURERS AAI BUSINESS MEETING & AWARDS PRESENTATIONS

SATURDAY, MAY 14 SATURDAY, MAY 14, 1:00 PM - 2:30 PM 6:00 PM, BALLROOM 6BC AAI reports on the “state of the association” to its members Ulrich H. von Andrian at every AAI annual meeting. Members will hear from the Harvard Medical School Executive Director, the Secretary-Treasurer, the Editor-in- Career decisions: how T cells remember Chief of The Journal of Immunology (The JI), and the Chair of pathogens the Committee on Public Affairs on the fi nancial standing of AAI, the status of The JI, important public policy issues, and other items of interest to the membership. Selected 2016 AAI awards will also be presented during this session.

AAI Distinguished Service Award Presentation SATURDAY, MAY 14, 1:00 PM SUNDAY, MAY 15 Mitchell Kronenberg, La Jolla Institute for 6:00 PM, BALLROOM 6BC Allergy & Immunology Susan K. Pierce For outstanding service to AAI and the NIAID, NIH immunology community as the AAI How B cells adapt in a changing world Secretary-Treasurer for two terms, 2009-2015

AAI annually provides more than 800 AAI meeting travel awards and grants to recognize the promise and bolster the professional development of investigators of all career stages, including underrepresented scientists and trainees. Travel award and grant presentations and acknowledgments will include: MONDAY, MAY 16 Presentations 6:00 PM, BALLROOM 6BC John J. O’Shea AAI-Thermo Fisher Trainee Achievement Awards NIAMS, NIH Chambers-eBioscience Memorial Award Cytokine signaling: genes, genomes, and Lefrançois-BioLegend Memorial Award drugs Lustgarten-eBioscience Memorial Award Pfi zer-Showell Travel Award

Acknowledgments

AAI Early Career Faculty Travel Grants AAI Laboratory Travel Grants FASEB MARC Poster/Platform (Oral) Presenter Travel Awards Sponsored by FASEB MARC Program under a grant from NIGMS, NIH [FASEB MARC Program: T36-GM08059-32 NCE] AAI Undergraduate Faculty Travel Grants AAI Trainee Abstract Awards AAI Trainee Poster Awards

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI AWARD LECTURES AND PRESENTATIONS

AAI Lifetime Achievement Award Presentation AAI-BioLegend Herzenberg Award Presentation and Lecture FRIDAY, MAY 13, 5:00 PM Generously supported by BioLegend Ballroom 6BC Chair: SUNDAY, MAY 15, 1:30 PM – 2:30 PM Dan R. Littman, HHMI, New York University School of Medicine, Ballroom 6E AAI President Chair: Award Recipient: Dan R. Littman, HHMI, New York University School of Medicine, Olivera J. Finn, University of Pittsburgh AAI President School of Medicine Award Recipient: John F. Kearney, University of Alabama, AAI President Dan R. Littman will introduce Birmingham the awardee and present the award prior to the B cell repertoire ontogeny infl uences allergy and start of the President’s Address. autoimmunity The AAI Lifetime Achievement Award is the highest honor bestowed by the AAI Council upon an AAI member. This award recognizes a deserving member for a career of scientifi c achievement and for AAI President Dan R. Littman, Gene Lay, Chief Executive contributions to AAI and fellow immunologists. Offi cer, BioLegend, and Craig Monell, Vice President of Sales, Marketing, and Business Development, BioLegend, will introduce AAI Distinguished Service Award Presentation the awardee and present the award immediately prior to Dr. SATURDAY, MAY 14, 1:00 PM Kearney’s lecture. AAI Business Meeting, Room 615-617 The AAI-BioLegend Herzenberg Award recognizes outstanding Chair: research contributions to the fi eld of immunology in the area of B cell biology. M. Michele Hogan, AAI Executive Director Award Recipient: Mitchell Kronenberg AAI-Steinman Award for Human Immunology , La Jolla Institute for Research Presentation and Lecture Allergy & Immunology SUNDAY, MAY 15, 4:30 PM – 5:30 PM AAI Executive Director M. Michele Hogan will Ballroom 6BC introduce the awardee and present the award. Chair: This award recognizes Dr. Kronenberg for Dan R. Littman, HHMI, New York University School of Medicine, outstanding service to AAI and the immunology community as the AAI President AAI Secretary-Treasurer for two terms, 2009-2015. Award Recipient: Lieping Chen, AAI-BD Biosciences Investigator Award Yale School of Medicine PD-1/PD-L1 blockade therapy for human Presentation and Lecture cancer: past, present and future Generously supported by BD Biosciences SATURDAY, MAY 14, 4:30 PM – 5:30 PM AAI President Dan R. Littman will introduce the awardee and present the award Ballroom 6BC immediately prior to Dr. Chen’s lecture. Chair: The AAI-Steinman Award for Human Immunology Research Dan R. Littman, HHMI, New York University School of Medicine, recognizes an individual who has made signifi cant contributions to AAI President the understanding of immune processes underlying human disease Award Recipient: pathogenesis, prevention, or therapy. Ming Li, Memorial Sloan Kettering Cancer Center and Cornell University Immunity and tolerance in cancer

AAI President Dan R. Littman and a representative of BD Biosciences will introduce the awardee and present the award immediately prior to Dr. Li’s lecture. The AAI-BD Biosciences Investigator Award recognizes an early- career investigator who has made outstanding contributions to the fi eld of immunology. www.IMMUNOLOGY2016.org AAI Excellence in Mentoring Award Presentation AAI-Thermo Fisher Meritorious Career Award MONDAY, MAY 16, 12:30 PM Presentation and Lecture Generously supported by Thermo Fisher Scientifi c Ballroom 6BC Chair: MONDAY, MAY 16, 4:30 PM – 5:30 PM Dan R. Littman, HHMI, New York University School of Medicine, Ballroom 6BC AAI President Chair: Award Recipient: Dan R. Littman, HHMI, New York University School of Medicine, Richard A. Flavell, HHMI, Yale School AAI President of Medicine Award Recipient: Kenneth M. Murphy, AAI President Dan R. Littman and Hongbo HHMI, Washington Chi, St. Jude Children’s Research Hospital, will University School of Medicine introduce the awardee and present the award Proper responses to pathogens – a DC / T cell prior to the start of the President’s Symposium. dialog The AAI Excellence in Mentoring Award recognizes exemplary career AAI President Dan R. Littman and a contributions to a future generation of scientists. representative of Thermo Fisher Scientifi c will introduce the awardee and present the award immediately prior to Dr. Murphy’s lecture. The AAI-Thermo Fisher Meritorious Career Award recognizes a mid-career scientist for outstanding research contributions to the fi eld of immunology.

The Journal of Immunology

Booth 256 Join us to celebrate the centennial year of The Journal of Immunology (The JI)!

First published in February 1916, The JI celebrates its centennial this year. Stop by The JI booth to view a gallery of more than 100 stunning covers of The JI, from the very first to some of the most recent. Every attendee will have the opportunity to own a piece of this historic art. Tickets within registration packages will entitle attendees to the chance of winning one of the displayed covers from drawings held throughout the meeting. Also, every scientific registrant visiting The JI booth will receive a centennial coffee mug! For insight on the history of The JI, visit www.jimmunol.org and click on the centennial banner.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI MAJOR SYMPOSIA

SATURDAY, MAY 14, 8:00 AM SUNDAY, MAY 15, 8:00 AM Major Symposium A: Macrophage Development Major Symposium C: A Breath of Fresh Air: New and Function in Health and Disease Developments in Respiratory Tract Immunity Ballroom 6BC Ballroom 6BC Chairs: Chairs:

Jessica A. Hamerman, Benaroya Research Institute Nicole Baumgarth, University of California, Davis Marco Colonna, Washington University School of Medicine Anuradha Ray, University of Pittsburgh School of Medicine Speakers: Speakers:

Christopher K. Glass, University of California, San Diego Anuradha Ray, University of Pittsburgh School of Medicine Infl uence of tissue environment on macrophage identity Maintenance of lung immune homeostasis and function Thomas J. Braciale, University of Virginia School of Medicine Frederic Geissmann, Memorial Sloan Kettering Cancer Center Early innate immune response to virus infection in the respiratory tract In vivo analysis of macrophage functions Nicole Baumgarth, University of California, Davis Jeffrey W. Pollard, University of Edinburgh Innate and adaptive B cell immunity in the respiratory tract Tumor associated macrophages: from mechanism to therapy Bart N. Lambrecht, University Ghent Catherine C. Hedrick, La Jolla Institute for Allergy and Epithelial and dendritic cell communication in type 2 immunity Immunology Dennis W. Metzger, Albany Medical College Monocyte subsets in cancer Immune dysfunction during infl uenza and susceptibility to Jessica A. Hamerman, Benaroya Research Institute secondary bacterial lung infections Macrophage differentiation during infl ammation Shabaana A. Khader, Washington University in St. Louis Marco Colonna, Washington University School of Medicine Vaccine immunity to tuberculosis: what to target? Brain macrophages and neurodegeneration Major Symposium D: Transcriptional Networks in Major Symposium B: Unconventional T Cells and Immune Cell Development Innate-Like Lymphocytes Ballroom 6E Ballroom 6E Chairs: Chairs: Barbara L. Kee, University of Chicago Rebecca L. O’Brien, National Jewish Health Jinfang (Jeff) Zhu, NIAID, NIH Luc Teyton , Scripps Research Institute Speakers:

Speakers: H. Leighton Grimes, Cincinnati Children’s Hospital Medical Center Rebecca L. O’Brien, National Jewish Health Using single-cell RNA-Seq for unbiased analysis of developmental Gamma/delta T cells prevent autoimmune attack by hierarchies enhancing Treg development Boris Reizis, New York University Langone Medical Center Yueh-Hsiu Chien, Stanford University Transcriptional control of dendritic cell differentiation Gamma-delta T cells: fi rst line of defense and beyond Hai-Hui (Howard) Xue, University of Iowa Luc Teyton, Scripps Research Institute Regulation of T cell identity by Tcf/Lef transcription factors New lipids for old T cells Dorina Avram, University of Florida Dale I. Godfrey, University of Melbourne Bcl11b in transcriptional control of T cells and innate The development and diversity of MR1-restricted MAIT cells lymphoid cells James McCluskey, University of Melbourne Jinfang (Jeff) Zhu, NIAID, NIH The conundrum of MAIT cells Heterogeneity of innate and adaptive lymphocytes regulated by Richard M. Locksley , HHMI, University of California, intricate balance between master transcription factors San Francisco Barbara L. Kee, University of Chicago Allergic immunity: new cells, new pathways Regulation of natural killer cell effector fate by the Ets1-E/Id protein transcription factor network

www.IMMUNOLOGY2016.org MONDAY, MAY 16, 8:00 AM TUESDAY, MAY 17, 8:00 AM Major Symposium E: Cell-Cell Communication Major Symposium G: T Cell Specialization in during Viral Infection Tissues: From Thymus to Periphery (and Back) Ballroom 6BC Ballroom 6BC Chairs: Chairs:

Tania H. Watts, University of Toronto Stephen C. Jameson, University of Minnesota Susan M. Kaech, HHMI, Yale University Donna L. Farber, Columbia University Medical Center Speakers: Speakers:

John R. Teijaro, Scripps Research Institute Stephen C. Jameson, University of Minnesota Employing activity-based chemoproteomic approaches to Regulation of memory T cell residency and recirculation understand virus-immune interactions Thomas S. Kupper, Brigham and Women’s Hospital, Frances E. Lund, University of Alabama, Birmingham Harvard Medical School Regulation of virus specifi c B cell fate decisions by the T-box Protective memory T cells in barrier tissues transcription factor, T-bet Donna L. Farber, Columbia University Medical Center Shane Crotty, La Jolla Institute for Allergy and Immunology Human T cell tissue compartmentalization: from naïve to memory Follicular helper T cells in infections and antiviral vaccines Martin Prlic, Fred Hutchinson Cancer Research Center Tania H. Watts, University of Toronto Human T cell function in healthy and infl amed mucosal tissues The where, when, and why of GITR/GITRL in control of viral infection Jonathan D. Powell, Johns Hopkins School of Medicine Susan M. Kaech, HHMI, Yale University Dissecting and targeting mTOR signaling in T cells Immunosuppressive vs. immunosupportive roles of IL-10 Paola Romagnoli, Institut National de la Santé et de la Recherche in antiviral immunity Médicale U1043, Toulouse, France Rama Rao Amara, Emory University Peripheral regulatory T lymphocytes recirculating to the thymus The dynamics of follicular CD4 and CD8 T cells during chronic suppress the development of their precursors SIV infection Major Symposium H: Novel Concepts in Major Symposium F: Putting the Biology into Neuroimmunology Systems Biology Ballroom 6E Ballroom 6E Chairs: Chairs: Jonathan Kipnis, University of Virginia School of Medicine Bali Pulendran, Emory Vaccine Center at Yerkes Zsuzsanna Fabry, University of Wisconsin W. Nicholas Haining, Harvard Medical School, Dana-Farber Speakers: Cancer Institute Jonathan Kipnis Speakers: , University of Virginia School of Medicine The role of meningeal lymphatics in CNS autoimmunity Harinder Singh, Cincinnati Children’s Hospital Medical Center Stephen P. Schoenberger, La Jolla Institute for Allergy Viewing the immune system through the lens of gene regulatory and Immunology networks Repertoire analysis of meningeal T cells W. Nicholas Haining, Harvard Medical School, Dana-Farber Dorian McGavern, NINDS, NIH Cancer Institute Dynamics of immune interactions that contribute to health and Epigenetic landscape of T cell exhaustion disease in the living brain Nir Yosef, University of California, Berkeley Zsuzsanna Fabry, University of Wisconsin Identifi cation of dendritic cell subsets in HIV-1 elite controllers Novel roles for cytokines regulating neuroimmune interactions in using single-cell RNA-Seq CNS trauma Galit Alter, Ragon Institute of MGH, MIT, and Harvard Francisco J. Quintana*, Brigham and Women’s Hospital, Mining for mechanisms of humoral immune protection using Harvard Medical School Systems Serology Regulation of CNS infl ammation Bali Pulendran , Emory Vaccine Center at Yerkes *Supported by the British Society for Immunology Systems vaccinology Claudia F. Lucchinetti, Mayo Clinic Mark M. Davis, HHMI, Stanford University NFljB signaling drives pro-granulocytic astroglial responses to the Nature, nurture, and the alpha beta TCR repertoire neuromyelitis optica IgG: pathogenic and therapeutic implications IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI COMMITTEE SYMPOSIA & SESSIONS

AAI CLINICAL IMMUNOLOGY COMMITTEE to expand the pre-application process; and efforts to enhance the reproducibility (through improved rigor and transparency) of Translational Research Toward Putting the research. Speakers will discuss the mechanisms and policies that Immune System to Sleep in Human Disease have already been implemented and provide insight into what may come next. Ample time will be provided for questions and answers. MONDAY, MAY 16, 3:45 PM – 5:45 PM Chairs: AAI EDUCATION COMMITTEE

Robert L. Modlin, University of California, Los Angeles; Chair, AAI Careers in Biotech: Panel Discussion and Clinical Immunology Committee Networking Agnes M. Azimzadeh, University of Maryland SATURDAY, MAY 14, 7:00 PM – 9:00 PM Speakers: Chair: Fred D. Finkelman, University of Cincinnati College of Medicine Nandita Bose Rapid suppression of IgE-mediated allergy , Biothera Emma Guttman-Yassky, Icahn School of Medicine at Mount Sinai Panelists: Medical Center Fiona Coats A paradigm shift in the pathogenesis and treatment of atopic dermatitis , Vice President of Marketing, Meso Scale Diagnostics Catherine M. Sanders Jeffrey V. Ravetch, Rockefeller University , Director-Scientifi c Liaison, Adaptive Immunomodulation by types I and II Fc receptors Biotechnologies Jose Luis Vela Stephen D. Miller, Northwestern University Medical School , Research Scientist, Novo Nordisk From bench to bedside: translation of a novel nanoparticle approach for Clifford D. Wright, Founder, RespirPharm Solutions tolerogenic therapy of immune-mediated diseases Many opportunities exist in industry for scientists with advanced Advances in translational immunology research have led to new degrees. There are positions in laboratory research, program tactics to dampen inappropriate or excessive immune responses management, business development, regulatory affairs, clinical trials as therapeutic approaches for autoimmune and infl ammatory oversight, medical liaison, and more. This panel features scientists diseases. This session will include discussion of present employed in a variety of positions in industry discussing their career approaches and future directions that will be valuable paths and the skills required for success in each. Following the panel to immunologists interested in translational research. discussion, enjoy casual conversation with the speakers and other scientists from industry at a networking reception. AAI COMMITTEE ON PUBLIC AFFAIRS Immunology Teaching Interest Group Hot Topics in NIH Funding and Research Policy SATURDAY, MAY 14, 11:00 AM – 12:30 PM SATURDAY, MAY 14, 10:15 AM – 12:15 PM Chair:

Chair: Julie M. Jameson, California State University, San Marcos Clifford V. Harding, Case Western Reserve University Discussion Leaders : AAI Committee on Public Affairs Chair Pierette M. Appasamy, Chatham University Speakers: Analogies and role-playing to “experience” immunology in an undergraduate immunology course Gail A. Bishop, University of Iowa Anil K. Bamezai Challenges and concerns from an investigator’s perspective , Villanova University Strategies to promote active learning culture in the classroom Richard K. Nakamura, Director, Center for Scientifi c Review, NIH Deborah M. Brown Peer review and grant mechanisms at NIH: what is changing? , University of Nebraska, Lincoln Just-in-Time Teaching strategies for an upper level immunology Richard J. Hodes, Director, National Institute on Aging, NIH course Analysis of research impact and implications for funding policy Jason S. Rawlings, Furman University Change at NIH continues to happen at a rapid pace, driven by Incorporating primary literature discussion in an undergraduate the president, Congress, NIH, and the scientifi c community. immunology course This session will explore several recent changes, including new Laurie P. Shornick, Saint Louis University funding mechanisms offered by several NIH institutes that fund A systems and Goldilocks approach to teaching immunobiology investigators rather than specifi c projects; changes—and proposed changes—to the peer review system, including a pilot program www.IMMUNOLOGY2016.org Are you looking for new ideas or strategies to enliven and improve • New PI: your teaching? If so, please join us for this informal and interactive - Attracting students and postdocs special interest group to focus on strategies to successfully convey Table Leaders: Robin Stephens, University of Texas Medical immunology concepts at the undergraduate and graduate level. Branch; Emma H. Wilson, University of California, Riverside Topics will include the concept and implementation of Just-in-Time - Preparing for promotion Teaching, strategies to incorporate primary literature discussion Table Leaders: Edward A. Clark, University of Washington into an undergraduate course, the use of a fl ipped classroom and Mitzi Nagarkatti, University of South Carolina School peer instruction to promote active learning in the classroom, and of Medicine more. The session will include ample time for open discussion and • networking. Current educators, new faculty, and trainees with an Negotiating an Academic Position Olivera J. “Olja” Finn interest in teaching are welcome. Table Leaders: , University of Pittsburgh School of Medicine; Roland K. Strong, Fred Hutchinson Cancer Research Center AAI EDUCATION COMMITTEE & • Undergraduate Institutions: fi nding the balance in teaching, AAI COMMITTEE ON THE STATUS OF WOMEN doing research Table Leaders: Paula M. Lutz, University of Wyoming Careers in Science Roundtable Laurie P. Shornick, St. Louis University • SUNDAY, MAY 15, 11:30 AM – 1:00 PM Mentoring Effectively Table Leaders: Gail M. Bishop, University of Iowa Chair: Klaus Ley, La Jolla Institute for Allergy & Immunology Networking Skills: how to build a network Virginia Shapiro, Mayo Clinic; Chair, AAI Committee on the Jane H. Buckner Status of Women Table Leaders: , Benaroya Research Institute Madeleine W. Cunningham, University of Oklahoma Health At this always popular session, you’ll have the opportunity to Sciences Center; Catherine C. “Lynn” Hedrick, La Jolla meet with scientists at your own career stage and with more Institute for Allergy & Immunology; Ashok Kumar, Wayne State experienced scientists to explore specifi c career issues important University to men and women in science today. Learn what others are Career and Family: balancing parenthood and career; thinking and gain insights into issues you are confronting in the dual career couple your own situation. Recently added topics offer insights into Table Leaders: Yueh-Hsiu Chien, Stanford University Medical NIH Study Sections, considerations for scientists in M.D., Ph.D. School; Janice J. Endsley, University of Texas Medical Branch, careers, and a number of ways scientists contribute to the Galveston; Jessica A. Hamerman, Benaroya Research Institute fi eld in non-research careers. Choose from these and the other Susan Kovats, Oklahoma Medical Research Foundation vital topics related to the environment you work in (academic Careers in Biotech and Industry: moving from academia to research, biotech industry, governmental agencies, non-profi ts), industry and vice versa the transitions from specifi c career stages, or issues in balancing Heather A. Arnett Tamar Boursalian career and family in any career path. Don’t miss this great Table Leaders: , Amgen; , Andrew C. Chan Marc A. Gavin networking opportunity! Registration Fee: $20 (Lunch included) Novo Nordisk; , Genentech; , Benaroya Research Institute; Gabriela Hernandez-Hoyos, Discussion topics and table leaders: Emergent BioSolutions; Mary E. Keir, Genentech; Steven D. Levin Mandy J. McGeachy Research Careers in Academia , Implicit Bioscience; , University of Pittsburgh; Catherine J. McMahan, Emergent BioSolutions • Graduate Student to Postdoc: fi nding a postdoc, interviewing Careers at Governmental Agencies Pooja Jain Yue-Ming Loo Table Leaders: , Drexel University; , Table Leaders: Timothy A. Gondre-Lewis, NIAID/NIH; Dorian B. University of Washington; Michelle A. Parent, University McGavern John J. O’Shea Susan K. Chander Raman , NINDS/NIH; , NIAMS/NIH; of Delaware; , University of Alabama, Pierce, NIAID/NIH Birmingham; James L. Riley, University of Pennsylvania Carol F. Webb NIH Study Section Insights , University of Oklahoma Health Sciences Center • • Grant Writing for Fellowships/Transition Awards Postdoc to PI: fi nding a position, interviewing, negotiating, Table Leaders: Kristin A. Hogquist, University of Minnesota lab start-up Center for Immunology; Scheherazade Sadegh-Nasseri, Johns Table Leaders: Shane Crotty, La Jolla Institute for Allergy & Lisa K. Denzin Hopkins Medical Institute Immunology; , Child Health Institute of N.J., • Rutgers; Michael A. Farrar, University of Minnesota Grant Writing for PIs Paula M. Kavathas Mitchell Kronenberg Table Leaders: Virginia Shapiro, Mayo Clinic , Yale School of Medicine; , Steven M. Varga La Jolla Institute for Allergy & Immunology; Michele A. Kutzler, , University of Iowa Drexel University College of Medicine; Ricardo Rajsbaum, The Physician Scientist: balancing clinical and research duties Malini Raghavan University of Texas Medical Branch, Galveston; , Table Leaders: Thomas Hawn, University of Washington Amariliz Rivera University of Michigan Medical School; , Penelope A. Morel, University of Pittsburgh Rutgers-New Jersey Medical School Continued, next page

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI COMMITTEE SYMPOSIA AND SESSIONS

Continued from previous page Research from the M.D., Ph.D. Perspective Mireia Guerau-de-Arellano, Ohio State University Table Leaders: David D. Chaplin, University of Alabama, Joseph Larkin, III, University of Florida Christopher Glass Birmingham; , University of California, Junior Faculty: preparing for promotion and tenure San Diego Table Leaders: Avery August, Cornell University College of Veterinary Non-Research Careers for Scientists: careers enabling scientists to Medicine; Prosper Boyaka, Ohio State University; advance the field away from the bench Floyd L. Wormley, Jr., University of Texas, San Antonio • Careers in Scientifi c Journals Academia or Industry: how to decide (or switch sides) Table Leaders: Peter T. Lee, Immunity; Jennifer H. Meyers, Table Leaders: Robert Balderas, BD Biosciences; James W. Lillard, The Journal of Immunology; Marjorie Cohn, The Journal of JYANT Technologies, Inc.; Karel Otero Gutierrez, Biogen Immunology; Jamie Wilson, Nature Immunology Government Agency Careers: CDC, FDA, NIH • Opportunities for Scientists in Foundations, Societies, and Schools Table Leaders: Marta Catalfamo, NIAID, NIH; Charles Egwuagu, Table Leaders: Catherine Grubin, Juanita High School NEI, NIH; Alison Mawle, CDC Thandi M. Onami, Gates Foundation; Mary T. Litzinger, AAI Non-Bench-Research Science Careers (Awards and Educational Programs); Elizabeth R. Walsh, AAI Peter T. Lee (Awards and Outreach Programs) Table Leaders: , Cell Press Editor, Immunity Thandi Onami, Bill & Melinda Gates Foundation (Program Offi cer, • Careers in Technology Transfer Global Health – HIV Vaccines); Jaconda Wagner, Wagner, Law LLC Table Leader: Nicole C. Robinson, Fred Hutchinson Cancer (intellectual property attorney) Research Center • Careers in Science Policy AAI Vanguard Lecture Table Leader: Lauren Gross, AAI (Public Policy and Government Monika Schneider Affairs); , AAI (Public Policy and Government Supported in part by a grant to the Federation of American Societies Affairs) for Experimental Biology (FASEB) from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health AAI MINORITY AFFAIRS COMMITTEE [FASEB MARC Program: T36-GM08059-32 NCE] MONDAY, MAY 16, 11:15 AM – 12:15 PM Careers Roundtable and Speed Networking Session Chair: Supported in part by a grant to the Federation of American Societies Cherié L. Butts, Biogen; Chair, AAI Minority Affairs Committee for Experimental Biology (FASEB) from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health Speaker: [FASEB MARC Program: T36-GM08059-32 NCE] Prosper N. Boyaka, Ohio State University SATURDAY, MAY 14, 11:45 AM – 2:15 PM Diversity: Lessons from regulation of mucosal Chair: immunity by toxins and microbiota

Cherié L. Butts, Biogen; Chair, AAI Minority Affairs Committee Since 2003, the AAI meeting has featured a scientifi c lecture presented by an AAI member Networking skills have never been more crucial to ensure success who is an underrepresented minority investigator. for early/mid-career scientists, including those traditionally Selected for their achievements in the fi eld of immunology, presenters under-represented in biomedical research. At the roundtable, are among the most prominent investigators in the fi eld and models take advantage of the opportunity to meet in small-group format of successful career development. with accomplished, senior immunologists to hear how they have handled the career challenges you now face and learn what they believe will work for you today. Then practice networking in a AAI PROGRAM COMMITTEE relaxed environment offering a structured networking exercise and personalized feedback on communicating your scientifi c Back to School: A Review of Four Fast-Moving Fields interests/objectives most effectively. Registration Fee: $20 (Includes lunch; coffee/cookies during networking hour.) FRIDAY, MAY 13, 2:30 PM – 4:30 PM Discussion topics and table leaders: Chairs:

Grad Student: finding a mentor; taking aim at postdoc training Wendy L. Havran, Scripps Research Institute; Chair, AAI Program Table Leaders: Margaret Bynoe, Cornell University College of Committee Eduardo Davila Veterinary Medicine; , University of Maryland Frances E. Lund, University of Alabama, Birmingham Greenebaum Cancer Center; Tonya Webb, University of Maryland School of Medicine Speakers: Postdoc: finding a mentor; taking aim at a faculty position John T. Chang, University of California, San Diego Robert J. Binder Table Leaders: , University of Pittsburgh Single-cell approaches in immunology www.IMMUNOLOGY2016.org Garry P. Nolan, Stanford School of Medicine AAI VETERINARY IMMUNOLOGY COMMITTEE High dimensional immune system imaging and the heterogeneity & AMERICAN ASSOCIATION OF VETERINARY illusion IMMUNOLOGISTS (AAVI) JOINT SYMPOSIUM Leonard D. Shultz, The Jackson Laboratory Humanized mice in translational immunology Vaccination: The Balance between Immunity and Pathogenesis Helen C. Su, NIAID, NIH Inborn errors in human immunity: recent advances SATURDAY, MAY 14, 12:30 PM – 2:30 PM This workshop intends to bring a broad audience up-to-date on a few emerging or rapidly changing fi elds or areas of technological Chairs: innovation. Expert lecturers will provide an overview of each Laurel J. Gershwin, University of California, Davis trending topic with an emphasis on communicating big picture Laura C. Miller concepts. , National Animal Disease Center, ARS, USDA Speakers:

AAI PUBLICATIONS COMMITTEE Linda J. Saif, Ohio Agricultural Research and Development Center, The Ohio State University Scientific Publishing: Writing, Responding to Gut reactions to probiotics, commensals, and antibiotics infl uence Reviewers, and Adhering to Ethical Standards immunity to rotavirus in neonates Jeffrey L. Stott SUNDAY, MAY 15, 12:30 PM – 2:30 PM , University of California, Davis, School of Veterinary Medicine Chairs: Controlling epizootic bovine abortion (foothill abortion): development and application of a live virulent vaccine Eugene M. Oltz, Washington University School of Medicine Julia F. Ridpath Chair, AAI Publications Committee , National Animal Disease Center, ARS, USDA Pamela J. Fink BVDV vaccines: the yin and yang of immunosuppression versus , University of Washington School of Medicine immune response Editor-in-Chief, The Journal of Immunology Shafiqul I. Chowdhury, Louisiana State University School of Speakers: Veterinary Medicine Targeting immunosuppressive and virulence genes for genetically Pamela J. Fink, University of Washington School of Medicine engineered BHV-1 vaccine: walking a fi ne line between reduced That’s the way it was: the fi rst 100 years of The Journal of Immunology pathogenicity and protective immune responses Eugene M. Oltz, Washington University School of Medicine Putting your data in the best light: tips on writing a scientifi c Drawing from both human and veterinary research, this year’s manuscript symposium will focus on the challenge in viral vaccine design of attenuating virulence while retaining protective immunogenicity. Kristin A. Hogquist, University of Minnesota Research highly relevant to infant immunization will cite the use of Responding to reviewers: what you want to say and what probiotics to enhance vaccine responses to human rotavirus in a you should say germ-free piglet model. The story of “foothill abortion” in western Pamela J. Fink , University of Washington School of Medicine states cattle will be used to illustrate the ways that understanding Much harder to correct than to avoid: ethical problems in scientifi c the unique pathogenesis of a pathogen can ultimately lead to a publishing successful vaccine. Finally, researchers studying pestiviruses and bovine herpes viruses will share how understanding protective In this session sponsored by the AAI Publications Committee, the immunity and viral pathogenesis is critical for development of Editor-in-Chief will look back at some fun facts from 100 years effective vaccines. of The Journal of Immunology – things were not always the way they are now! In addition, experienced editors will address factors to consider when preparing a manuscript, as well as advice on responding to reviewers’ comments. Finally, the Editor-in-Chief will discuss items that could constitute ethical problems and describe how authors can avoid such missteps in scientifi c publishing.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS NIH INSTITUTE-SPONSORED SYMPOSIA

NIH INSTITUTE-SPONSORED SYMPOSIA National Institute on Aging (NIA) Symposium: The Interplay between Chronic Viral Infection and National Cancer Institute (NCI) Symposium: Immunosenescence Extracellular RNA Communication in the Immune System SUNDAY, MAY 15, 3:45 PM – 5:45 PM Chairs: MONDAY, MAY 16, 3:45 PM – 5:45 PM Rebecca A. Fuldner, NIA, NIH Chairs: Beth D. Jamieson, University of California, Los Angeles K. Mark Ansel , University of California, San Francisco Speakers: T. Kevin Howcroft, NCI, NIH Beth D. Jamieson, University of California, Los Angeles Speakers: The impact of HIV infection on aging of the human immune system Gyongyi Szabo, University of Massachusetts Medical School Graham P. Pawelec Extracellular vesicles and microRNAs in innate immune cell , University of Tübingen communication in the liver The impact of CMV infection on immunity and survival in older humans Ryan M. O’Connell, University of Utah Janet E. McElhaney MicroRNA-containing exosomes and the regulation of , Advanced Medical Research Institute of Canada infl ammatory responses CMV and frailty: contributions to immune senescence Sean X. Leng Amy S. Major, Vanderbilt University Medical Center , Johns Hopkins University School of Medicine HDL-associated small RNA communication in autoimmunity Impact of CMV on T cell immunity in HIV infection and aging K. Mark Ansel, University of California, San Francisco Regulated microRNA release within extracellular vesicles during National Institute of Environmental Health Sciences T cell activation (NIEHS) Symposium: Environmental Triggers of Autoimmunity National Institute of Allergy and Infectious Diseases (NIAID) Symposium: Development SATURDAY, MAY 14, 10:15 AM – 12:15 PM and Function of the Infant Immune System Chairs:

SATURDAY, MAY 14, 12:30 PM – 2:30 PM Michael C. Humble, NIEHS, NIH Chairs: Keith B. Elkon, University of Washington

Mercy PrabhuDas, NIAID, NIH Speakers: Wendy Davidson , NIAID, NIH Keith B. Elkon, University of Washington Speakers: Impact of UV light on innate immunity in lupus DeLisa Fairweather Joseph (Mike) McCune, University of California, San Francisco , Mayo Clinic Human fetal immune development and its impact on neonatal Endocrine disruptors alter infl ammatory heart disease by immune function activating mast cells Tai Guo Kristina De Paris, University of North Carolina, Chapel Hill , University of Georgia Cytokine signaling in the fi rst year of life Exacerbation of type I diabetes in female NOD mice following James E. Gern developmental exposure to bisphenol A and genistein , University of Wisconsin, Madison James P. Luyendyk Progressive development of the human immune system , Michigan State University Nicholas W. Lukacs Mechanisms at the interface of environmental exposure and , University of Michigan autoimmunity Microbiome, immune function, and pulmonary disease

www.IMMUNOLOGY2016.org GUEST SOCIETY SYMPOSIA

GUEST SOCIETY SYMPOSIA Canadian Society for Immunology (CSI) Symposium: Mechanisms of Tolerance American Association of Veterinary Immunologists and Autoimmunity (AAVI) and AAI Veterinary Immunology Committee SUNDAY, MAY 15, 8:00 AM – 10:00 AM Joint Symposium: Vaccination: The Balance between Immunity and Pathogenesis Chairs: Colin C. Anderson SATURDAY, MAY 14, 12:30 PM – 2:30 PM , University of Alberta Megan K. Levings, University of British Columbia Chairs: Speakers: Laurel J. Gershwin, University of California, Davis Amit Bar-Or, McGill University Laura C. Miller, National Animal Disease Center, ARS, USDA GM-CSF expressing B cells in autoimmune disease Speakers: Jan P. Dutz, University of British Columbia Linda J. Saif, Ohio Agricultural Research and Development Center, Regulation of immunity and tolerance in the skin The Ohio State University Sylvie Lesage, University of Montreal Gut reactions to probiotics, commensals, and antibiotics infl uence Immunogenetics of CD4–CD8– T cells that confer immune tolerance immunity to rotavirus in neonates in NOD mice Jeffrey L. Stott , University of California, Davis, School of Veterinary Megan K. Levings, University of British Columbia Medicine Functions and therapeutic applications of regulatory T cells Controlling epizootic bovine abortion (foothill abortion): development Colin C. Anderson, University of Alberta and application of a live virulent vaccine Co-inhibitory control of homeostasis Julia F. Ridpath, National Animal Disease Center, ARS, USDA BVDV vaccines: the yin and yang of immunosuppression versus Chinese Society of Immunology (CSI) Symposium: immune response Innate Immunity in Stress and Homeostasis Shafiqul I. Chowdhury, Louisiana State University School of Veterinary Medicine SATURDAY, MAY 14, 8:00 AM – 10:00 AM Targeting immunosuppressive and virulence genes for genetically engineered BHV-1 vaccine: walking a fi ne line between reduced Chairs: pathogenicity and protective immune responses Zhigang Tian, University of Science and Technology of China American Society of Gene & Cell Therapy (ASGCT) Weiping Zou, University of Michigan School of Medicine Symposium: Genetic Engineering of T Cells Speakers: MONDAY, MAY 16, 10:15 AM – 12:15 PM Chengjiang Gao, Shandong University Chairs: Feedback regulation of innate antiviral signaling Rongbin Zhou, University of Science and Technology of China Michel Sadelain, Memorial Sloan Kettering Cancer Center The mechanisms for the regulation of NLRP3 infl ammasome Stanley Riddell, Fred Hutchinson Cancer Research Center Zhihua Liu, Institute of Biophysics of the Chinese Academy Speakers: of Sciences Michel Sadelain Commensal bacteria direct selective cargo sorting to promote , Memorial Sloan Kettering Cancer Center symbiosis Genetic engineering of chimeric antigen receptors Hongyan Wang Gwendolyn Binder-Scholl , Shanghai Institutes for Biological Sciences, , Adaptimmune LLC Chinese Academy of Sciences T cell receptors Identifi cation of VEGFR3 and STK4 as new targets for Stanley Riddell, Fred Hutchinson Cancer Research Center infl ammation-related diseases What is the best T cell subset? Dawang Zhou, Xiamen University Ann M. Leen, Baylor College of Medicine The kinases Mst1 and Mst2 positively regulate phagocytic Genetically modifi ed virus-specifi c cells induction of reactive oxygen species and bactericidal activity

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS GALA ™

Seattle Center 325 Fifth Avenue North Seattle, 98109

AAI GALA MONDAY, MAY 16, 2016 7:00 PM-9:30 PM

GENEROUSLY SPONSORED BY BIOLEGEND

Whether your idol is Jimi Hendrix or Han Solo, you’ll enjoy this world famous museum of popular music and science fiction. See guitars signed by rock legends, hand-written lyrics, costumes and props from popular sci-fi films, and more. Dance to live bands, record your own performance in the EMP’s Sound Lab, and enjoy drinks and food by Wolfgang Puck! Your meeting badge enables you to take the 90-second Monorail ride to the Gala for free!

Open to all IMMUNOLOGY 2016™ attendees. IMMUNOLOGY 2016 IMMUNOLOGY Come as you are, directly from the Center. Attendees must be at least 21 years of age. Meeting badge required. www.IMMUNOLOGY2016.org GUEST SOCIETY SYMPOSIA

Chinese Society of Immunology, Taiwan (CSIT) International Complement Society (ICS) Symposium: Glycoimmunology: Glycans and Symposium: Specific Targeting of Complement Lectins as Therapeutic Targets Pathways for Clinical Benefit

SATURDAY, MAY 14, 12:30 PM – 2:30 PM MONDAY, MAY 16, 10:15 AM – 12:15 PM Chairs: Chairs:

Jenny P. Ting, University of North Carolina, Chapel Hill V. Michael Holers, University of Colorado, Denver Shie-Liang Hsieh, Academia Sinica Jessy J. Alexander, University at Buffalo Speakers: Speakers:

Chi-Huey Wong, Academia Sinica Menno Van Lookeren Campagne, Genentech, Inc. Chemistry and biology of glycosylation: carbohydrate-based Illuminating targets for age-related macular degeneration cancer vaccine Beth Stevens, Children’s Hospital, Harvard Medical School Fu-Tong Liu, Academia Sinica Immune mechanisms of synapse loss in health and disease Galectins in innate immunity Joshua M. Thurman, University of Colorado, Denver Alice Yu, Chang Gung University The point of no return: IgM, complement, and the progression of Cancer immunotherapy targeting tumor-associated kidney disease glycosphingolipids Antonio Risitano, University of Naples Shie-Liang Hsieh, Academia Sinica Lessons from treatment of paroxysmal nocturnal hemoglobinuria Targeting CLEC5A for the treatment of fl aviviral infection (PNF): multiple dimensions of complement

German Society for Immunology (DGfI) Japanese Society for Immunology (JSI) Symposium: Intracellular Immunosensors Symposium: Immune System Regulation, Function, and Related Diseases: Symposium by JSI Awardees MONDAY, MAY 16, 10:15 AM – 12:15 PM MONDAY, MAY 16, 3:45 PM – 5:45 PM Chairs: Chairs: Hans-Martin Jäck, University of Erlangen-Nürnberg Kenji Kabashima, Kyoto University Jürgen Wienands, University of Göttingen Yoshiyuki Goto, Chiba University Speakers: Speakers: Jürgen Wienands, University of Göttingen Kensuke Takada Immunology in Germany , University of Tokushima Thymoproteasome-dependent positive selection of CD8 T cells Olaf Groß, Technical University of München Kiyoshi Hirahara Activation of the Nlrp3 infl ammasome , Chiba University Axel Roers Molecular mechanism for the maintenance of immune , University of Dresden homeostasis via CD4+ T cells Aicardi-Goutières syndrome: inappropriate intracellular sensing of Noriko Komatsu endogenous nucleic acids , University of Tokyo Plasticity of Foxp3+ T cells and its impact on autoimmune arthritis Angela Rösen-Wolff, University of Dresden Yoshiyuki Goto The role of caspase-1 in intracellular immunosensing , Chiba University Commensal bacteria and ILC3 regulate intestinal homeostasis Gunther Hartmann, University of Bonn Kenji Kabashima Immune sensing of RNA by RIG-I , Kyoto University Cutaneous immune responses to external antigens

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS GUEST SOCIETY SYMPOSIA

Korean Association of Immunologists (KAI) and Society for Immunotherapy of Cancer (SITC) Association of Korean Immunologists in America Symposium: Overcoming Failure of Immune (AKIA) Symposium: Immune Regulation of Viral Checkpoint Inhibition in Patients with Cancer Pathogenesis SUNDAY, MAY 15, 12:30 PM – 2:30 PM SUNDAY, MAY 15, 12:30 PM – 2:30 PM Chairs: Chairs: Martin A. Cheever, Fred Hutchinson Cancer Research Center Young S. Hahn , University of Virginia School of Medicine Augusto C. Ochoa, Louisiana State University Health Eui-Cheol Shin, Korea Advanced Institute of Science Sciences Center and Technology Speakers: Speakers: Martin A. Cheever, Fred Hutchinson Cancer Research Center Eui-Cheol Shin, Korea Advanced Institute of Science Introduction: immune checkpoint failures: gravity of the problem and Technology Matthew D. Hellmann, Memorial Sloan Kettering Cancer Center IL-15 and NKG2D in virus-induced immunopathogenesis Genetic and mutational causes of failure Sang-Jun Ha , Yonsei University Antoni Ribas, University of California, Los Angeles Role of PD-1 in regulatory T cells during chronic virus infection Adaptive immune resistance Heung Kyu Lee , Korea Advanced Institute of Science Lisa M. Coussens, Oregon Health and Science University and Technology Neutralizing cancer: promoting chronic infl ammation Dysbiosis contributes to impaired antiviral immunity in the Augusto C. Ochoa genital mucosa , Louisiana State University Health Sciences Center Sujin Lee , Emory University Metabolic suppression Broadly neutralizing antibodies induced by multivalent Francesco M. Marincola inactivated rhinovirus , Sidra Medical and Research Center Agents to overcome failure Michael W. Cho, Iowa State University Developing vaccine strategies to modulate immunogenicity of Society for Leukocyte Biology (SLB) Symposium: B cell epitopes Metabolic Regulation of Immunity

Society for Glycobiology (SfG) Symposium: SUNDAY, MAY 15, 12:30 PM – 2:30 PM Glycobiology of Immune Responses Chairs:

SATURDAY, MAY 14, 10:15 AM – 12:15 PM Mark A. Wallet, University of Florida Chairs: Matthew J. Delano, University of Michigan Speakers: Fikri Y. Avci, University of Georgia C. Henrique Serezani Linda G. Baum, University of California, Los Angeles , Indiana University Understanding impaired host defense in type 1 diabetes by looking Speakers: at the PGE2/DC/Th17 axis Daniel J. Perry Linda G. Baum, University of California, Los Angeles , University of Florida Regulation of immune cell function by galectin-glycoprotein Metabolic profi ling of human PBMC subsets lattices on the cell surface Emily L. Goldberg, Yale University Bruce S. Bochner, Northwestern University Beta-hydroxy butyrate, an alternate metabolic fuel, Airway glycans that control allergic lung infl ammation by inhibits neutrophilic infl ammation by blocking NLRP3 interacting with eosinophil siglecs infl ammasome activation Joseph E. Qualls Taia Wang, Rockefeller University , Cincinnati Children’s Hospital IgG Fc glycoforms in protective and pathogenic antibody responses Macrophage L-citrulline metabolism improves anti-mycobacterial host defense in vivo Brian A. Cobb, Case Western Reserve University Carbohydrate-mediated immune regulation Fikri Y. Avci, University of Georgia New insights on carbohydrate antigens and immune responses

www.IMMUNOLOGY2016.org The American Association of Immunologists thanks the following sponsors for their generous support of IMMUNOLOGY 2016™ AAI Annual Meeting | May 13–17, 2016 | Seattle, Washington Thank you to our Premier Sponsors

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IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS GUEST SOCIETY SYMPOSIA

The Obesity Society (TOS) Symposium: Society of Mucosal Immunology (SMI) Symposium: Inflammation Fuels Obesity-Associated Cancers Innate Regulation of Th2 Immunity SUNDAY, MAY 15, 10:15 AM – 12:15 PM SATURDAY, MAY 14, 3:45 PM – 5:45 PM Chairs: Chairs: Gerald V. Denis, Boston University School of Medicine Cathryn Nagler, University of Chicago Barbara S. Nikolajczyk, Boston University School of Medicine Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health Speakers:

Speakers: Kristy A. Brown, Hudson Institute, Melbourne Infl ammation and breast cancer: driving tumor growth through David Artis, Weill Cornell Medical College dysregulated metabolism and estrogen regulation Immunity at barrier surfaces Mario Kratz, Fred Hutchinson Cancer Research Center Cathryn Nagler, University of Chicago Adipose tissue infl ammation: a potential link between obesity Regulation of allergic responses to food by commensal bacteria and cancer Marsha Wills-Karp, Johns Hopkins Bloomberg School of Lydia Lynch, Brigham and Women’s Hospital, Harvard Medical Public Health School Novel role for the SAA-FPR2-IL-33 axis in allergic asthma Obese NK cells lack energy to kill cancer cells B. Brett Finlay, University of British Columbia Neil M. Iyengar, Memorial Sloan Kettering Cancer Center The role of the microbiota in asthma Local and systemic effects of white adipose tissue infl ammation: Society for Natural Immunity (SNI) Symposium: linking obesity and cancer NK Cells and ILCs: Development and Disease

SUNDAY, MAY 15, 3:45 PM – 5:45 PM Chairs:

Adelheid Cerwenka, German Cancer Research Center Andreas Diefenbach, University of Mainz Medical Center Speakers:

Adelheid Cerwenka, German Cancer Research Center Harnessing natural killer cells against tumors Andreas Diefenbach, University of Mainz Medical Center Transcriptional control of innate lymphoid cell fate decisions Todd A. Fehniger, Washington University School of Medicine microRNA regulation of NK cells Aharon G. Freud, Ohio State University Human innate lymphoid cell development in secondary lymphoid tissues

www.IMMUNOLOGY2016.org CAREER DEVELOPMENT SESSIONS

CAREER DEVELOPMENT SESSIONS Discussion Leaders: Pierette M. Appasamy, Chatham University Through workshops, roundtables, and one-on-one counseling, Anil K. Bamezai, Villanova University IMMUNOLOGY 2016™ provides critical career development Deborah M. Brown programs. , University of Nebraska, Lincoln Jason S. Rawlings Career sessions and services this year include: , Furman University Laurie P. Shornick • Careers in Biotech: Panel Discussion and Networking , Saint Louis University • Careers and Networking Roundtables (2) Are you looking for new ideas or strategies to enliven and improve your teaching? If so, please join us for this informal and interactive • How to Convert Your CV into a Resumé (followed by one-on-one special interest group which will focus on strategies that instructors consulting) can use to successfully convey immunology concepts to students • Immunology Teaching Interest Group at the undergraduate and graduate level. Topics will include the concept and implementation of Just-in-Time Teaching, strategies • Interviewing for a Job to incorporate primary literature discussion into an undergraduate • NIH Grants Workshop course, the use of a fl ipped classroom and peer instruction to • Scientifi c Publishing promote active learning in the classroom, and more. The session will include ample time for open discussion and networking. • Secrets for a Successful Postdoctoral Fellowship Current educators, new faculty, and trainees with an interest in AAI is also offering an online and on-site Jobs Board free to meeting teaching are welcome. registrants and exhibitors and a new NIH Grant Review and Funding Information Room! Careers Roundtable and Speed Networking Session NEW! NIH Grant Review and Funding Information Sponsored by the AAI Minority Affairs Committee Room Supported in part by a grant to the Federation of American Societies NIH program and review staff will be available in Room 400 for for Experimental Biology (FASEB) from the National Institute of individual conversations and consultations. A schedule will be General Medical Sciences (NIGMS), National Institutes of Health posted online and on site to show specifi c times staff members will [FASEB MARC Program: T36-GM08059-32 NCE] be available to answer questions about the scientifi c review process, grant/fellowship opportunities, and NIH institute-specifi c interests. SATURDAY, MAY 14, 11:45 AM – 2:15 PM Chair: How to Convert Your CV into a Resumé Cherié L. Butts, Biogen; Chair, AAI Minority Affairs Committee SATURDAY, MAY 14, 9:00 AM – 10:00 AM Networking skills have never been more crucial to ensure success for early/mid-career scientists, including those traditionally Speaker: under-represented in biomedical research. At the roundtable, take advantage of the opportunity to meet in small-group format Derek Haseltine, Director, Career Development Center, Baylor with accomplished, senior immunologists to hear how they have College of Medicine handled the career challenges you now face and learn what they For anyone seeking a job outside of academe, how you present believe will work for you today. Then practice networking in a yourself on paper is critical. A well prepared resumé can make all relaxed environment offering a structured networking exercise the difference in securing that interview. The focus of this session and personalized feedback on communicating your scientifi c will be on the important elements of a resumé, the differences interests/objectives most effectively. Registration Fee: $20 between a resumé and the standard academic curriculum vitae, and (Includes lunch; coffee/cookies during networking hour.) the information needed to make a good impression. In this special Discussion topics and table leaders: career development session, attendees will be instructed in how • to transform their CVs into professional resumés. Small breakout Grad Student: fi nding a mentor; taking aim at postdoc training sessions for individual consulting will follow from 10:30 AM to 12:30 • Postdoc: fi nding a mentor; taking aim at a faculty position PM. Bring your CV! • Junior Faculty: preparing for promotion and tenure • Immunology Teaching Interest Group Academia or Industry: how to decide (or switch sides) • Government Agency Careers: CDC, FDA, NIH Sponsored by the AAI Education Committee • Non-Bench-Research Science Careers SATURDAY, MAY 14, 11:00 AM – 12:30 PM Table Leaders: See Committee Symposia and Sessions Chair:

Julie M. Jameson, California State University, San Marcos

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS CAREER DEVELOPMENT SESSIONS

Careers in Biotech: Panel Discussion and Networking number of ways scientists contribute to the fi eld in non-research careers. Choose from these and the other vital topics related Sponsored by the AAI Education Committee to the environment you work in (academic research, biotech SATURDAY, MAY 14, 7:00 PM – 9:00 PM industry, governmental agencies, non-profi ts), the transitions from specifi c career stages, or issues in balancing career and Chair: family in any career path. Don’t miss this great networking opportunity! Registration Fee: $20 (Lunch included) Nandita Bose, Biothera Panelists: Discussion topics: Research Careers in Academia Fiona Coats, Vice President of Marketing, Meso Scale Diagnostics • Catherine M. Sanders, Director-Scientifi c Liaison, Adaptive Graduate Student to Postdoc: fi nding a postdoc, interviewing Biotechnologies • Postdoc to PI: fi nding a position, interviewing, negotiating, Jose Luis Vela, Research Scientist, Novo Nordisk lab start-up • Clifford D. Wright, Founder, RespirPharm Solutions New PI: - Attracting students and postdocs Many opportunities exist in industry for scientists with advanced degrees. There are positions in laboratory research, program - Preparing for promotion management, business development, regulatory affairs, • Negotiating an Academic Position clinical trials oversight, medical liaison, and more. This panel • features scientists employed in a variety of positions in industry Undergraduate Institutions: fi nding the balance in teaching, discussing their career paths and the skills required for success in doing research each. Following the panel discussion, enjoy casual conversation • Mentoring Effectively with the speakers and other scientists from industry at a Networking Skills: how to build a network networking reception. Career and Family: balancing parenthood and career; the dual career couple Interviewing for a Job Careers in Biotech and Industry: moving from academia to SUNDAY, MAY 15, 9:00 AM – 10:00 AM industry and vice versa Careers at Governmental Agencies Speaker: NIH Study Section Insights Derek Haseltine, Director, Career Development Center, • Grant Writing for Fellowships/Transition Awards Baylor College of Medicine • Grant Writing for PIs This session will be focused on tips and techniques to help you The Physician Scientist: balancing clinical and research duties successfully navigate the interview process. Emphasis will be on how you can present yourself in the best possible light. You will Research from the M.D., Ph.D. Perspective also learn how to respond to unexpected questions. This session Non-Research Careers for Scientists: careers enabling scientists to is open to anyone but is especially intended for student and advance the field away from the bench postdoctoral attendees. • Careers in Scientifi c Journals Careers in Science Roundtable • Opportunities for Scientists in Foundations, Societies, and Schools • Sponsored by the AAI Education Committee & AAI Committee on the Careers in Technology Transfer Status of Women • Careers in Science Policy Table Leaders: See Committee Symposia and Sessions SUNDAY, MAY 15, 11:30 AM – 1:00 PM Chair: NIH Grants Workshop: Demystifying the Grant Virginia Shapiro, Mayo Clinic; Chair, AAI Committee on the Application Submission, Review, and Funding Status of Women Processes

At this always popular session, you’ll have the opportunity to SUNDAY, MAY 15, 12:30 PM – 2:30 PM meet with scientists at your own career stage and with more experienced scientists to explore specifi c career issues important Chairs: to men and women in science today. Learn what others are Tina McIntyre thinking and gain insights into issues you are confronting in your , Center for Scientifi c Review, NIH own situation. Recently added topics offer insights into NIH study Joseph Breen, NIAID, NIH sections, considerations for scientists in M.D.-Ph.D. careers, and a www.IMMUNOLOGY2016.org Panelists: Secrets for a Successful Postdoctoral Fellowship Tina McIntyre , Scientifi c Review Offi cer, III Study Section, MONDAY, MAY 16, 1:30 PM – 2:30 PM Immunology IRG, DPPS, Center for Scientifi c Review, NIH Speaker: Deborah Hodge, Scientifi c Review Offi cer, Immunology Fellowships and AREA Study Section, Immunology IRG, DPPS, Daniel J. Campbell, Full Member, Benaroya Research Institute; Center for Scientifi c Review, NIH Affi liate Associate Professor and Graduate Program Coordinator, Joseph Breen, Section Chief, Basic Immunology Branch, Division Department of Immunology, University of Washington of Allergy, Immunology and Transplantation, NIAID, NIH A postdoctoral fellowship is the time to develop research skills you T. Kevin Howcroft, Chief, Cancer Immunology and Hematology will need to succeed as an independent scientist. It is, however, just Etiology Branch, Division of Cancer Biology, NCI, NIH as important to realize that you need to prepare for a career path at the same time. This session will highlight ways of getting the most This workshop will provide participants with an overview of NIH out of your postdoctoral fellowship, relating successfully with your grant submission, assignment, review, and funding opportunities. mentor, and understanding how to use the resources available to you Emphasis will be given to identifi cation of the most appropriate to ensure that your training prepares you adequately for a seamless funding agencies and mechanisms available through NIH, how transition into the next phase of your career. to make an application “reviewer friendly,” and other strategies that contribute to applications that succeed in obtaining research funding. The workshop will also provide information on how to understand the peer review system, which is essential to competing successfully for funding, with a focus on recent changes to the review process. NIH review and program staff will provide a broad array of expertise and encourage questions from seminar participants. This workshop is open to anyone interested in learning more about preparing an NIH grant application and obtaining NIH funding. Trainees and independent investigators are welcome.

Scientific Publishing: Writing, Responding to Reviewers, and Adhering to Ethical Standards

Sponsored by the AAI Publications Committee SUNDAY, MAY 15, 12:30 PM – 2:30 PM Chairs:

Eugene M. Oltz, Washington University School of Medicine, Chair, AAI Publications Committee Pamela J. Fink, University of Washington School of Medicine, Editor-in-Chief, The Journal of Immunology Speakers:

Pamela J. Fink, University of Washington School of Medicine Eugene M. Oltz, Washington University School of Medicine Kristin A. Hogquist, University of Minnesota Pamela J. Fink, University of Washington School of Medicine In this session sponsored by the AAI Publications Committee, the Editor-in-Chief will look back at some fun facts from 100 years of The Journal of Immunology – things were not always the way they are now! In addition, experienced editors will address factors to consider when preparing a manuscript, as well as advice on responding to reviewers’ comments. Finally, the Editor-in-Chief will discuss items that could constitute ethical problems and describe how authors can avoid such missteps in scientifi c publishing.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI PROGRAM COMMITTEE | AAI ABSTRACT PROGRAMMING CHAIRS

2015–2016 AAI PROGRAM COMMITTEE

AAI gratefully acknowledges the efforts of the Program Committee for IMMUNOLOGY 2016™.

Wendy L. Havran, Chair Frances E. Lund David W. Pascual The Scripps Research Institute University of Alabama, Birmingham University of Florida Marlene Bouvier Daniel J. Campbell José R. Conejo-Garcia University of Illinois, Chicago Benaroya Research Institute Wistar Institute James E. Crowe, Jr. Jennifer L. Gommerman Jennifer A. Punt Vanderbilt University Medical Center University of Toronto Columbia University College of Physicians Daniel H. Kaplan Paul Kubes & Surgeons University of Minnesota University of Calgary Anne I. Sperling University of Chicago

AAI ABSTRACT PROGRAMMING CHAIRS

AAI gratefully acknowledges the efforts of the Abstract Programming Chairs for IMMUNOLOGY 2016™. Antigen Processing and Immediate Hypersensitivity, Innate Immune Responses Transplantation Immunology Presentation Asthma, and Allergic and Host Defense: Molecular Donna L. Farber Malini Raghavan Responses Mechanisms Columbia University University of Michigan Paul J. Bryce Gregory M. Barton Medical Center Medical School Northwestern University University of California, Pavan Reddy Scheherazade Feinberg School of Medicine Berkeley University of Michigan Sadegh-Nasseri Mitchell H. Grayson Katherine A. Fitzgerald Medical Center Johns Hopkins School Medical College of Wisconsin University of Massachusetts of Medicine Medical School Tumor Immunology Immune Mechanisms of Chrystal M. Paulos Basic Autoimmunity Human Disease Lymphocyte Differentiation Medical University of South Laura Mandik-Nayak Clara Abraham and Peripheral Maintenance Carolina Lankenau Institute for Yale University Nicole Baumgarth Weiping Zou Medical Research Jane H. Buckner University of California, Davis University of Michigan Chandra Mohan Benaroya Research Institute Ross M. Kedl University of Houston University of Colorado, Vaccines and Immune Response Denver Immunotherapy Cellular Adhesion, Migration, Regulation: Cellular Sandra Demaria and Infl ammation Mechanisms Microbial, Parasitic, and Weill Cornell Medical College Minsoo Kim Andrew L. Mellor Fungal Immunology Kohtaro Fujihashi George S. Deepe University of Rochester Newcastle University University of Alabama, Yoji Shimizu Thomas C. Mitchell University of Cincinnati Birmingham College of Medicine University of Minnesota University of Louisville Joanne Turner Medical School School of Medicine Veterinary and Comparative Ohio State University Immunology Cytokines and Chemokines Immune Response Cynthia L. Baldwin and Their Receptors Regulation: Molecular Mucosal and Regional University of Massachusetts Laurie E. Harrington Mechanisms Immunology Jeffrey A. Yoder Rachel M. Gerstein Timothy L. Denning University of Alabama, North Carolina State University Birmingham University of Massachusetts Georgia State University Mandy J. McGeachy Medical School Dana J. Philpott Viral Immunology University of Pittsburgh Mark H. Kaplan University of Toronto Julia L. Hurwitz Indiana University St. Jude Children’s Research Hematopoiesis and Immune School of Medicine Therapeutic Approaches to Hospital System Development Autoimmunity Steven M. Varga José Alberola-Ila Innate Immune Responses Jennifer H. Anolik University of Iowa Oklahoma Medical Research and Host Defense: Cellular University of Rochester Foundation Mechanisms Medical Center Michael A. Farrar Thirumala-Devi Kanneganti Olaf Stüve University of Minnesota St. Jude Children’s Research University of Texas Hospital Southwestern Medical Center David M. Underhill Cedars-Sinai Medical Center IMMUNOLOGY 2016™ Annual Meeting of The American Association of Immunologists

MAY 13–17, 2016

WASHINGTON STATE CONVENTION CENTER . SEATTLE, WASHINGTON Jobs Board A Free Recruiting Service for Registrants and Exhibitors Post Online and Meet On-site

AAI is offering career services to both job seekers and employers through a Jobs Board free to meeting registrants and exhibitors at www.immunology2016.org/jobs-board. Job Seekers! Whatever your career stage, use this career service at IMMUNOLOGY 2016™ to enhance your professional development! Q Job Postings. Review the online AAI Jobs Board to identify postings you wish to pursue. (View new Advance Postings through May 4. Watch for On-site Postings, online or on paper in the Exhibit Hall!) Q Direct Access to Recruiters. Job postings will include recruiters’ e-mail addresses so that you can contact them directly.

Employers! Advertise your position on a virtual Jobs Board located on the IMMUNOLOGY 2016™ website. By including a contact email, you will receive inquiries directly. Q Advance Postings. Postings will be accepted as of February 15 and will remain online until the end of the meeting. To post job listings in advance of the meeting, contact [email protected]. Advance Postings must be submitted to AAI by May 4, 2016. Q On-site Postings. After May 4, 2016, employers wishing to advertise a job on the IMMUNOLOGY 2016™ +PCT
#PBSE may still do so by visiting the AAI Office in the Washington State Convention Center between
9:00 AM and 5:00 PM. Ads submitted on-site will be posted on the bulletin board in the Exhibit Hall.

Save Thousands of Dollars in Recruiting Expenses. Take advantage of this complimentary hiring opportunity at IMMUNOLOGY 2016™. To register for the meeting, visit www.immunology2016.org/register.

www.IMMUNOLOGY2016.orgIMMUNOLOGY 20162016 ™ THE AMERICANAME ASSOCIATION OF IMMUNOLOGISTS POSTER SESSIONS & BLOCK SYMPOSIA

POSTER SESSIONS & BLOCK SYMPOSIA EXHIBITOR HALL PASSPORT PROGRAM Abstracts of unpublished, original research are presented during Poster Sessions and Block Symposia (oral presentations FILL OUT YOUR EXHIBIT HALL PASSPORT of poster data). This is perhaps the most dynamic aspect of FOR A CHANCE TO WIN ONE OF THREE $250 the AAI annual meeting. Take part in face-to-face discussions with abstract authors and learn about their most recent, AMERICAN EXPRESS GIFT CARDS! unpublished research. Poster Sessions will be held daily (unopposed by any other sessions) in the Exhibit Hall from Entries must be received by Monday, May 16, at 2:00 PM. 2:30 PM – 3:45 PM. The drawing will be held during the Poster Presentations on Monday, May 16 from 2:30 PM – 3:45 PM. You’ll fi nd your Passport in your meeting bag or you may pick one up at the AAI Booth (250).

VISIT THE AAI BOOTH (250) TO LEARN ABOUT AN EXCITING NEW AAI CAREER DEVELOPMENT EXHIBITOR WORKSHOPS RESOURCE Be sure to take advantage of the knowledge-building opportunities The Career Advisory Board (CAB) presented in Exhibitor Workshops. Located on the Exhibit Floor, these workshops explore exhibitors’ latest technologies, products, A referral service for connecting young PIs with more senior PIs and services through demonstrations and discussions. for advice on how to manage your fi rst lab! Workshops are planned and conducted by exhibitors; the listing of The CAB is sponsored by the Committee on the Status of those workshops does not constitute endorsement of any products Women but is open to all junior faculty in AAI. or services by AAI.

AAI Courses in Immunology 2016 Introductory Course in Immunology July 9–14, 2016 • Long Beach Convention Center • Long Beach, California This comprehensive two-part course provides an in-depth overview of the basics of immunology.

2016 Advanced Course in Immunology July 31–August 5, 2016 • Seaport World Trade Center • Boston, Massachusetts This intensive course is directed toward advanced trainees and scientists who wish to expand or update their understanding of the field.

For more information visit www.aai.org/Education/Courses Please direct inquiries to [email protected] or 301-634-7178.

www.IMMUNOLOGY2016.org Th e American Association of Immunologists Gratefully Acknowledges the Generous Gold Sponsorship of

for the following

IMMUNOLOGY 2016™ support:

Chambers-eBioscience Memorial Award

Lustgarten-eBioscience Memorial Award

Meeting Bags

Program Support

IMMUNOLOGY 2016™

May 13 – 17, 2016 • Seattle, Washington • Washington State Convention Center

™ www.IMMUNOLOGY2015.org IMMUNOLOGY 2016 THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS SOCIAL EVENTS

SOCIAL EVENTS

New Member Reception (By Invitation Only) Service Appreciation Reception (By Invitation Sponsored by the AAI Membership Committee Only) FRIDAY, MAY 13, 4:00 PM – 4:45 PM Generously sponsored by BioLegend (BADGE AND INVITATION REQUIRED) SUNDAY, MAY 15, 7:30 PM – 9:30 PM (BADGE AND INVITATION REQUIRED) AAI wishes to welcome new regular and associate members joining AAI for the fi rst time. AAI President Dan Littman and other AAI At this important event, AAI leadership honors the association’s leaders look forward to meeting you personally. Please join us dedicated member volunteers—the committee members, editors, with your invitation in hand for light refreshments and casual mentors, instructors, and others—who work on the membership’s conversation. behalf throughout the year by giving generously of their time in support of the AAI mission. Open by invitation to 2015–2016 The Journal of Immunology (The JI) Editorial AAI volunteers. Board Dinner and Meeting (By Invitation Only) IMMUNOLOGY 2016™ Gala Generously sponsored by Dartmouth Journal Services Generously sponsored by BioLegend (BADGE REQUIRED) SATURDAY, MAY 14, 7:00 PM – 10:00 PM MONDAY, MAY 16, 7:00 PM – 9:30 PM This working dinner is held each year at the annual meeting to provide EMP MUSEUM Editorial Board members the valuable opportunity to meet in person 325 FIFTH AVENUE NORTH to discuss items of interest and concern about The JI. SEATTLE CENTER

Whether your idol is Jimi Hendrix or Han Solo, you’ll enjoy this world famous museum of popular music and science fi ction. See displays of guitars signed by rock legends, hand-written lyrics, costumes and props from popular sci-fi fi lms, and more. Dance to live bands, record your own performance in the EMP Sound Lab, and enjoy drinks and food by Wolfgang Puck! Your meeting badge enables you to take the 90-second Monorail ride to the Gala for free!

GUEST SOCIETIES

AAI welcomes the following Guest Societies International Complement Society (ICS) presenting symposia in their respective Japanese Society for Immunology (JSI) areas at IMMUNOLOGY 2016™ Korean Association of Immunologists (KAI) American Association of Veterinary and Association of Korean Immunologists in Immunologists (AAVI) America (AKIA) American Society of Gene & Cell Therapy Society for Glycobiology (SfG) (ASGCT) Society for Immunotherapy of Cancer (SITC) Canadian Society for Immunology (CSI) Society for Leukocyte Biology (SLB) Chinese Society of Immunology (CSI) Society of Mucosal Immunology (SMI) Chinese Society of Immunology, Taiwan (CSIT) Society for Natural Immunity (SNI) German Society for Immunology (DGfI) The Obesity Society (TOS)

www.IMMUNOLOGY2016.org Th e American Association of Immunologists Gratefully Acknowledges the Generous Platinum Sponsorship of

for the

IMMUNOLOGY 2016™ GALA MONDAY, MAY 16 • 7:00 PM – 9:30 PM

Service Appreciation Reception

Lefrançois-BioLegend Memorial Award

AAI-BioLegend Herzenberg Award and Lecture

Meeting Lanyards

IMMUNOLOGY 2016™

May 13 – 17, 2016 • Seattle, Washington • Washington State Convention Center

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI TRAVEL AWARD RECIPIENTS

2016 AAI Travel Award Recipients

Pfi zer-Showell Travel Award Li-Fan Lu, Ph.D. Assistant Professor University of California, San Diego Lustgarten-eBioscience Memorial Award Margaret S. Bynoe, Ph.D. Associate Professor Cornell University Chambers-eBioscience Memorial Award Vinit Kumar, Ph.D. Staff Scientist The Wistar Institute Lefrançois-BioLegend Memorial Award Michael G. Constantinides, Ph.D. Postdoctoral Fellow NIAID, NIH

AAI-Thermo Fisher Trainee Achievement Awards Timotheus Y.F. Halim, Ph.D. Timothy E. O’Sullivan, Ph.D. Postdoctoral Fellow Research Scholar MRC Laboratory of Molecular Biology Memorial Sloan Kettering Cancer Center Emma L. Kuan, Ph.D. Xiaodi Wu Postdoctoral Research Associate Graduate Student Benaroya Research Institute Washington University School of Medicine Si Ming Man, Ph.D. Zhenyu Zhong, Ph.D. Postdoctoral Fellow Postdoctoral Fellow University of California, San Diego St. Jude Children’s Research Hospital

www.IMMUNOLOGY2016.org 2016 AAI TRAINEE ABSTRACT AWARDEES

Awarded to AAI Trainee Members (students and postdoctoral fellows) whose fi rst-author abstracts are selected for presentation in AAI Block Symposia. Award amounts vary according to recipient’s years of consecutive membership.

THIRD-YEAR (OR LONGER) Sara Cohen, Ph.D. Eunsoo Kim Julita Ramirez, D.V.M., Ph.D. MEMBERS Center for Infectious Disease Ohio State University University of Washington Research Amina Abdul Qayum Lauren Kinner Priscilla S. Redd Virginia Commonwealth University Guoliang Cui, Ph.D. University of Pittsburgh School Georgia Regents University Yale School of Medicine of Medicine School of Medicine Dawn K. Reichenbach, Ph.D. Elisabeth B. Adkins Elizabeth M. Dam, Ph.D. Kathryn A. Knoop, Ph.D. University of Minnesota Benaroya Research Institute Washington University School Jackson Laboratory Lydia M. Roberts, Ph.D. of Medicine in St. Louis Joselyn Allen Payal Damani-Yokota NIAID, NIH University of Massachusetts, Peter D. Krueger Pennsylvania State University Levi Rupp, Ph.D. Amherst University of Minnesota Medical University of California, Nansalmaa Amarsaikhan, Ph.D. School Indiana University School Pritesh Desai San Francisco University of Florida Chantal Kuhn, Ph.D. of Medicine Shirdi E. Schmiel Brigham and Women’s Hospital Kristin G. Anderson, Ph.D. Jessica L. Doerner University of Minnesota Albert Einstein College of Medicine Ping-Chang Kuo, Ph.D. University of Washington Mark Singh, Ph.D. Indiana University School Rodney Dorand, Jr. Benaroya Research Institute Shaikh M. Atif, Ph.D. of Medicine Case Western Reserve University National Jewish Health Roberto Tinoco, Ph.D. Masayuki Kuraoka, Ph.D. Avijit Dutta, Ph.D. Sanford-Burnham Medical Todd Bartkowiak, M.S. Duke University University of Texas Graduate Chang Gung Memorial Hospital Research Institute and Chang Gung University Brandon Kwong, Ph.D. School of Biomedical Sciences, Alexander Tong NCI, NIH Houston Jie Geng, Ph.D. Case Western Reserve University University of Michigan Medical Tyler Landrith, M.P.H. Jean-Christophe Beltra Alexander Tsai School University of California, Riverside University of Montreal University of Maryland, Baltimore Sara Gibson Baoyu Liu, Ph.D. Anna Bird Siva Karthik Varanasi University of Alabama, Birmingham Emory University School University of Rochester University of Tennessee of Medicine Jacqueline J. Glascock, Ph.D. Jennifer Blanchfi eld, Ph.D. Jocelyn Wang University of Missouri Ke Liu Emory University Cornell University Cincinnati Children’s Hospital Donald Gracias, Ph.D. Ashley R. Burg Medical Center Rui Yang, M.B.Ch.B. La Jolla Institute for Allergy University of Alabama, Birmingham University of Vermont and Immunology Jason Lomueller, Ph.D. Alayna Caffrey University of Pittsburgh Shuyu Yao, D.V.M., Ph.D. Timotheus Halim, Ph.D. Dartmouth Geisel School of Indiana University Medicine MRC Laboratory of Molecular Americo H. Lopez-Yglesias, Biology Ph.D. Karim Yatim, M.D. Tara Capece, M.P.H. University of Rochester Medical University of Pittsburgh Daehee Han, Ph.D. University of Rochester School Center of Medicine and Dentistry Institute for Basic Science Autumn York Zheng Lou, Ph.D. University of California, Mohammad Haque, Ph.D. Sandra Cascio, Ph.D. University of Texas Health Science Los Angeles Pennsylvania State University University of Pittsburgh School Center, San Antonio of Medicine College of Medicine Mary H. Young, Ph.D. Michelle N. Messmer, Ph.D. Center for Infectious Disease Gerard Hernandez Mir, M.S. Shilpak Chatterjee, Ph.D. Roswell Park Cancer Institute Research Medicine University of South University of Pittsburgh School Carolina of Medicine Eslam Mohamed Yevgeniy Yuzefpolskiy Georgia Regents University Pennsylvania State University Fei Chen, M.D. Kirsten M. Hooper Rutgers New Jersey Medical Temple University School of Juan Moliva Jun Zhang, Ph.D. School Medicine Ohio State University Oregon Health and Science University Nicholas M. Chesarino Fany M. Iseka Michelle Nelson, Ph.D. Ohio State University College University of Nebraska Medical Medical University of South Center Carolina of Medicine SECOND-YEAR MEMBERS Jennifer Jacobsen Jaehak Oh, Ph.D. Hyoung-Soo Cho Priti Agarwal, M.B.B.S., M.P.H. University of Massachusetts University of Chicago University of California, San Francisco University of Massachusetts Medical School Alison Johnson, Ph.D. Medical School Seung-Chul Choi, Ph.D. Albert Einstein College of Medicine Mallory L. Paynich Loyola University Chicago Swadhinya Arjunaraja, Ph.D. University of Florida Sabina Kaczanowska Uniformed Services University of Chun Chou University of Maryland, Baltimore Sivakumar Periasamy, D.V.M., the Health Sciences Washington University School Ph.D. of Medicine in St. Louis Albany Medical College

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 2016 AAI TRAINEE ABSTRACT AWARDEES

Bianca Baker, Ph.D. Jenna Guthmiller Saisha Nalawade, M.S. Cheng-Jang Wu, Ph.D. Virginia Commonwealth University University of Oklahoma Health University of Texas, San Antonio University of California, San Diego Science Center Tessa Bergsbaken, Ph.D. SuFey Ong, Ph.D. Lihong Wu, Ph.D. University of Washington Emily A. Hemann, Ph.D. Benaroya Research Institute Texas Tech University Health University of Washington Science Center Semir Beyaz Timothy O’Sullivan, Ph.D. Harvard Medical School Matthew A. Huggins Memorial Sloan Kettering Yongyong Yan, M.D. Mayo Clinic Andrew Borkowski, Ph.D. Cancer Center Texas Tech University Health Science Center Scripps Research Institute April M. Huseby Patrick A. Paez, M.S. Mayo Graduate School Amanda Burmeister Virginia Commonwealth University Beng San Yeoh Pennsylvania State University University of North Carolina, Terri Iwata, D.V.M., Ph.D. Preeyam S. Patel Charlotte University of Washington University of Alabama, Birmingham Miao Yu, Ph.D. Georgia Regents University Catherine Cai Nathan Jacobs Kathryn L. Pothoven Saint Louis University Emory University School Northwestern University Zeb Zacharias,M.S. of Medicine University of Iowa Weirong Chen, D.V.M. Eduardo Reyes-Vargas University of Missouri Laura K. Johnston University of Utah School Michael Zhang Northwestern University Liang Cheng, Ph.D. of Medicine University of Iowa Carver College of Medicine University of North Carolina, Ahmad Karim, Ph.D. Brian T. Saunders Chapel Hill Case Western Reserve University Washington University School Chao Zhong, Ph.D. of Medicine in St. Louis Talyn Chu Thayer King NIAID, NIH University of Washington Emory University School Matthew J. Scheffel Qifan Zhu of Medicine Curtis A. Clark Medical University of St. Jude Children’s Research South Carolina University of Texas Health Science Purna Krishnamurthy, M.S. Hospital Center, San Antonio Indiana University School Breanna Scorza of Medicine University of Iowa Chelsea Corradetti FIRST-YEAR MEMBERS Temple University School Abirami Kugadas, D.V.M., Ph.D. Neekun Sharma, Ph.D. of Medicine Brigham and Women’s Hospital, University of Kansas Medical Kristin N. Adams, Ph.D. Harvard Medical School Center Center for Infectious Disease Stacey A. Cranert, Ph.D. Research Cincinnati Children’s Hospital Sanjay Kumar, Ph.D. Akhilesh K. Singh, Ph.D. Medical Center Alabama State University Seattle Children’s Research Nicholas M. Adams Institute Memorial Sloan Kettering Cancer Leilani Cruz Xin Li, D.V.M. Center University of California, San Diego University of Georgia Vishal Singh, Ph.D. Pennsylvania State University Renan A. Aguilar-Valenzuela, Barsha Dash Baoming Liu M.D., Ph.D. Mayo Graduate School University of Tennessee Health Timothy T. Spear Emory University Science Center Loyola University Chicago Christopher Davitt, Ph.D. Billur Akkaya, M.D., Ph.D. Tulane University Yang Liu J. Michael Stolley NIAID, NIH University of Texas Health Science Priyadharshini Devarajan, Ph.D. University of Washington Center, San Antonio Munir Akkaya, M.D., Ph.D. University of Massachusetts Kavya Swaminathan, Ph.D. NIAID, NIH Medical School Chunchi Lu, M.D. Stanford University School University of Washington of Medicine Cindy Audiger, M.S. Brittney A. Dinkel University of Montreal Mayo Graduate School Si Ming Man, Ph.D. Alexandru Tatomir, M.D. St. Jude Children’s Research Alexander Bally Justin Drerup University of Maryland School Hospital Emory University University of Texas Health Science of Medicine Center, San Antonio Rebecca Martin, Ph.D. Phyu Thwe Kankana Bardhan, Ph.D. Virginia Commonwealth University Beth Israel Deaconess Medical Jeffrey M. Duggan University of Vermont School of Medicine Center, Harvard Medical School Benaroya Research Institute Tania Velez Saumya Maru Neda Barjesteh, Ph.D. Paul Dunbar Feinberg School of Medicine, Pennsylvania State University University of Guelph Emory University Northwestern University College of Medicine Chaitali Basole Alison J. Eastman Brandon Walling Paul W. McDonald, Ph.D. University of Connecticut Health University of Michigan University of Rochester School Virginia Tech Carilion School of of Medicine and Dentistry Center Erica Fleming-Trujillo Medicine and Research Institute Zachary Benet Loyola University Chicago Haiguang Wang Arnav Mehta, Ph.D. University of Minnesota University of Michigan Ramya Ganesan David Geffen School of Medicine, Julie Wang Alix K. Berglund, D.V.M. Wright State University University of California, Pennsylvania State University North Carolina State University Los Angeles Nicholas Giovannone College of Medicine College of Veterinary Medicine Brigham and Women’s Hospital Joshua Moreau Daniel Wikenheiser Emilie Bernatchez University of Toronto Harshita Gupta, Ph.D. University of Arkansas for Laval University University of Texas Health Science Paulus Mrass, M.D. Medical Science Molly Boland Center, San Antonio University of New Mexico Caylin G. Winchell University of Alabama, Birmingham Claire Gustafson, Ph.D. Katherine A. Murphy, Ph.D. University of Arkansas for Stanford University University of Minnesota Medical Science

www.IMMUNOLOGY2016.org 2016 AAI TRAINEE ABSTRACT AWARDEES

James R. Bowen Steven de Jesus-Carrion, Ph.D. Richard M. Jin Katherine MacDonald, Ph.D. Emory University School Benaroya Research Institute University at Buffalo, State Center for Drug Research and of Medicine University of New York Shirley Dehn Development Jacob S. Bowers Northwestern University Jarrod S. Johnson, Ph.D. Shivana M. Maharaj Medical University of South Center for Infectious Disease Roshanak Derakhshandeh, M.D. Roswell Park Cancer Institute Carolina Research University of Maryland School Maksim Mamonkin, Ph.D. Erica L. Buonomo of Medicine Christopher Jondle Baylor College of Medicine University of Virginia University of North Dakota Li Y. Drake, M.D., Ph.D. Samira Mansouri Elise Burger Mayo Clinic Steven Josefowicz, Ph.D. Albany Medical College University of Rochester Medical Rockefeller University Frédéric Duval, M.S. Katrina Mar Center University of Montreal Atsushi Kadowaki, M.D. University of Texas Southwestern Kristina Burrack, Ph.D. National Center of Neurology Maria Edilova Brett Marro, Ph.D. University of Minnesota and Psychiatry, Japan University of Toronto Scripps Research Institute Kaitlin Carroll Jong Hoon Kim, M.D. Zhichao Fan, Ph.D. Bradley N. Martin Cincinnati Children’s Hospital Korea Advanced Institute La Jolla Institute for Allergy Cleveland Clinic Medical Center of Science and Technology and Immunology Ryan J. Martinez Patricia Castillo Jane Klann Alvaro Figueiredo, Ph.D. Emory University University of Pittsburgh School University of California, San Diego University of Texas Health Science of Medicine Divij Mathew Center, San Antonio Byunghee Koh University of Colorado School Jessica A. Chacon, Ph.D. Indiana University School Kristin K. Fino, Ph.D. of Medicine Perelman School of Medicine, of Medicine Pennsylvania State University University of Pennsylvania Theresa Mau College of Medicine Weimin Kong, Ph.D. University of Michigan Karthik Chandiran Temple University Kristin Gabor, Ph.D. University of Massachusetts Cameron McDonald-Hyman NIEHS, NIH Jonathan J. Kotzin University of Minnesota Medical Yu-Han Chang, M.S. University of Pennsylvania Ebony Gary School University of Toronto Drexel University College Paulette Krishack, Ph.D. Cody C. McHale Rudragouda Channappanavar, of Medicine University of Chicago University of South Carolina D.V.M., Ph.D. Clair Geary Emma Kuan, Ph.D. School of Medicine University of Iowa Weill Cornell Graduate School Benaroya Research Institute Meagan K. McMahon Colin A. Chavel, Ph.D. of Medical Science Devesha Kulkarni, Ph.D. Deakin University Roswell Park Cancer Institute Saba Ghassemi, Ph.D. Washington University School Christopher McQuinn, M.D. Wanjiao Chen University of Pennsylvania of Medicine in St. Louis Ohio State University University of Texas Health Science Aaron Gingerich Wing Lam Center, San Antonio Amit Mehta, Ph.D. University of Georgia Washington University in St. Louis La Jolla Institute for Allergy Zeyu Chen Jacquelyn A. Gorman, Ph.D. Sasha E. Larsen and Immunology Perelman School of Medicine, Seattle Children’s Research Uniformed Services University of University of Pennsylvania Genita Metzler Institute the Health Sciences University of Washington Sunglim Cho, Ph.D. Elizabeth Gray, Ph.D. Limin Li, Ph.D. University of California, San Diego Bibhuti B. Mishra, D.Sc. University of Washington Nanjing University University of Massachusetts Jeff Choi Teri Greiling, M.D., Ph.D. Wei Li, M.D., Ph.D. Medical School Stanford University School Yale School of Medicine University of Michigan of Medicine Kristen L. Mittelsteadt Kelsey Haist Xudong Li, Ph.D. University of Washington Basak B. Cicek University of Colorado School Salk Institute for Biological Studies University of Connecticut Health Alma N. Mohebiany of Medicine Center Chrissie Lim Johannes Gutenberg Yuan He, Ph.D. University of Washington University Mainz Teresa Collins University of Michigan University of Florida Sangho Lim Peter A. Morawski, Ph.D. Nicholas J. Hess Hanyang University NIAID, NIH Marjorie Cote, Ph.D. University of Illinois La Jolla Institute for Allergy and Wen-Hsuan Lin, M.D., Ph.D. Nadine N. Morgan Immunology Nicholas C. Hoffend Columbia University Medical University of Alabama, Birmingham Roswell Park Cancer Institute Center Amy N. Courtney, Ph.D. Wayne T. Muraoka, Ph.D. Baylor College of Medicine Shiqian Huang Yang-Ding Lin Trudeau Institute Shanghai Jiao Tong University Pennsylvania State University Jolie G. Cullen Arpita Myles, Ph.D. School of Medicine Peter Doherty Institute Rui-Xian Liu, M.S. University of Pennsylvania Daniela Janevska Sun Yat-sen University Rony Dahan, Ph.D. Yasuhiro Nagai, Ph.D. Feinberg School of Medicine, Rockefeller University Cesar Lopez Angel University of Pennsylvania Northwestern University Stanford University School Satinder Dahiya, Ph.D. Elizabeth Naglak Jessica Jang of Medicine Children’s Hospital of Philadelphia University of Arkansas for University of California, Riverside Cameron Louttit Medical Science Brian Daniels, Ph.D. Abigail P. Jarret University of Michigan University of Washington Ruth J. Napier, Ph.D. University of Washington Oregon Health and Science University

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 2016 AAI TRAINEE ABSTRACT AWARDEES

Lilli R. Neal Helia Sanchez, Ph.D. Tian Sun Xiaodi Wu Medical University of University of Texas Health Science University of Toronto Washington University School South Carolina Center, San Antonio of Medicine in St. Louis Phillip A. Swanson, II, Ph.D. Lori M. Neal, Ph.D. James Sanford NINDS, NIH Houjun Xia, Ph.D. University of Michigan University of California, San Diego University of Michigan Sophina Taitano Donald Ngwa Kaitlin Sawatzki University of Michigan Yingju Xia, Ph.D. East Tennessee State University Boston University School Deakin University Zeshan Tariq of Medicine Carleigh O’Brien NIAMS, NIH Richard F. Xiang University of Virginia School Kristin M. Schroeder University of Calgary Rachel Temple, Ph.D. of Medicine University of Colorado School Dartmouth Geisel School Zhaoqi Yan of Medicine Shannon K. Oda, Ph.D. of Medicine University of Alabama, Birmingham Fred Hutchinson Cancer Michael Schultz Jeffrey Teoh ChiaoWen Yang, Ph.D. Research Center University of Alabama, Birmingham University of Virginia Genentech, Inc. Livia Odagiu, M.S. Young-Jin Seo, Ph.D. Gengwen Tian Shugang Yao University of Montreal Emory University Baylor College of Medicine University of Alberta Jeremy O’Sullivan, Ph.D. Sergey S. Seregin, Ph.D. Yuan Tian Panpan Yi, M.D. Feinberg School of Medicine, University of Michigan Medical University of Alabama, Birmingham University of Texas Medical Northwestern University School Branch, Galveston Leticia Tordesillas, Ph.D. Emrah Ozay Javeed A. Shah, M.D. Icahn School of Medicine, Mount Catherine C. Yin, Ph.D. University of Massachusetts, University of Washington Sinai SRI International Amherst Ho Pan Sham, Ph.D. Tri M. Tran, Ph.D. Lucy B. Young, Ph.D. Antonio J. Pagan, Ph.D. Brigham and Women’s Hospital NIAMS, NIH University of Washington University of Cambridge Namit Sharma, D.V.M., Ph.D. Kathryn Tuttle Kyra D. Zens, M.P.H. M. Kazim Panjwani Hospital for Sick Children University of Colorado School Columbia University Medical University of Pennsylvania Shalu Sharma Kharkwal, Ph.D. of Medicine Center Joanna Pawlak, M.S. Albert Einstein College of Medicine Laura A. Vella, M.D., Ph.D. Faya Zhang, M.S. Leiden University Tian Shen University of Pennsylvania Washington State University Virginia Pedicord, Ph.D. University of Texas Health Allen M. Vong Monan Angela Zhang, Ph.D. Rockefeller University Science Center, San Antonio University of Massachusetts Qu Biologics Inc. Megan A. Peppenelli, Ph.D. Megha Shettigar Medical School Ting-ting Zhang, Ph.D. State University of New York Rutgers University Hongbin Wang, D.V.M. Yale School of Medicine Upstate Medical University Guilan Shi, M.D., Ph.D. University of Florida Ying Zhang Erwan Pernet, Ph.D. Texas Tech University Health Jing Wang University of Pennsylvania McGill University Health Center Science Center Tsing Hua University Fei Zhao Rachel Perret, Ph.D. Zaynab Sidi Mohamed Ellen J. Wehrens, Ph.D. University of Toronto Fred Hutchinson Cancer University of Florida University of California, San Diego Research Center Zhenyu Zhong, Ph.D. Chloe K. Slichter Kayla A. Weiss, Ph.D. University of California, San Diego Anne M. Pesenacker, Ph.D. University of Washington Albert Einstein College of Medicine University of British Columbia Dihan Zhu, Ph.D. Bailee H. Sliker Robin A. Welsh Nanjing University Kathleen Pestal University of Nebraska Johns Hopkins University School University of Washington Medical Center of Medicine Lei Qin, Ph.D. Norah L. Smith, Ph.D. Erin E. West, Ph.D. Northwestern University Cornell University NHLBI, NIH James L. Quinn Laura M. Snell, Ph.D. Christella E. Widjaja, Ph.D. Oklahoma Medical Research Princess Margaret Hospital University of California, San Diego Foundation Katja Srpan, Pharm.D. Erin Willis, Ph.D. Harini Raghu, Ph.D. University of Manchester Oklahoma State University Center Stanford University School Elizabeth C. Stahl for Veterinary Health Science of Medicine University of Pittsburgh School Rebecca A. Wilshusen Kristin Renkema, Ph.D. of Medicine University of Nebraska University of Minnesota Ryan P. Staupe Medical Center Timothy R. Rosean, Ph.D. University of Pennsylvania Ashley Wilson, Ph.D. University of Virginia Catherine Steer University of Virginia Benyamin Rosental, Ph.D. British Columbia Cancer Agency Shin-Rong Wu Stanford University Megan E. Stoley University of Michigan Blanca E. Ruiz-Medina, Ph.D. University of Iowa Te-Chia Wu, Ph.D. University of Texas, El Paso Amy Stone, Ph.D. Jackson Laboratory Robert Saddawi-Konefka, Ph.D. University of Washington Tuoqi Wu, Ph.D. University of California, San Diego Spencer W. Stonier, Ph.D. NHGRI, NIH U.S. Army Medical Research Institute of Infectious Diseases www.IMMUNOLOGY2016.org 2016 AAI TRAINEE POSTER AWARDEES

Awarded to AAI Trainee Members (students and postdoctoral fellows) whose first-author abstracts are deemed exceptional among abstracts selected exclusively for poster presentation

Daniel Abebayehu Karl Fischer, M.S. Taryn E. Mockus Erin M. Theisen Virginia Commonwealth University University of Nebraska Medical Pennsylvania State University University of Wisconsin, Madison Center College of Medicine Alaa Ali Kerri R. Thomas University of Ottawa Jennie A. Hamilton Jana L. Mooster, Ph.D. University of Washington University of Alabama, Birmingham Oregon Health and Science University Gunjan Arora, Ph.D. Jeffrey Tomalka, Ph.D. NIAID, NIH Luke Heil Rosemary E. Morman Case Western Reserve University University of Kentucky Purdue University Mariam Bakshi Te-Chen Tzeng, Ph.D. Texas A&M University Rana Herro, Ph.D. James New University of Massachusetts La Jolla Institute for Allergy University of Alabama, Birmingham Medical School Mark A. Barnes, Jr., Ph.D. and Immunology University of California, Riverside Kishan K. Nyati, Ph.D. Adam Utley David J. Holthausen Osaka University Roswell Park Cancer Institute Mireya Becerra-Diaz, Ph.D. Emory University Johns Hopkins University School Amy V. Paschall Janine van Duijn of Medicine Yu-Hsuan Huang, M.S. Georgia Regents University Leiden University University of British Columbia David F. Boyd, Ph.D. Rhiannon Penkert, Ph.D. Jennifer L. Vella, M.S. St. Jude Children’s Research Li-Yin Hung, Ph.D. St. Jude Children’s Research Dartmouth College Hospital Hospital University of California, Daniel Verbaro San Francisco Stephanie L. Brandt Kushal Prajapati, M.S. Washington University School Indiana University School Tracy In Loyola University Chicago of Medicine in St. Louis of Medicine Sunnybrook Research Institute Kendra Quicke Xianxiu Wan, Ph.D. Claire M. Buchta Michael Lee Emory University School University of Texas Medical Branch, University of Virginia Temple University of Medicine Galveston Thomas Burn Yuejin Liang, Ph.D. Jingjing Ren, M.D., Ph.D. Rui Wang Perelman School of Medicine, University of Texas Medical Branch, Virginia Polytechnic Institute University of Texas Health Science University of Pennsylvania Galveston and State University Center, San Antonio Samantha Chalmers Chih-Chung Lin Justin Roby, Ph.D. Pamela T. Wong, Ph.D. Albert Einstein College of Medicine Washington University School University of Washington University of Michigan Medical of Medicine in St. Louis School Krishan D. Chhiba Kelsey Roe, Ph.D. Feinberg School of Medicine, Stefanie N. Linch, Ph.D. University of Washington Yee Wu, Ph.D. MRC Laboratory of Molecular Northwestern University Earle A. Chiles Research Institute, Rejane Rua, Ph.D. Providence Cancer Center Biology Kibaek Choe NINDS, NIH Ying-Yu Wu, Ph.D. Korea Advanced Institute of Science Brandon M. Linz Carolyn Rydyznski Oklahoma Medical Research and Technology University of North Carolina, Cincinnati Children’s Hospital Chapel Hill Foundation William E. Coyne, M.S. Medical Center Zhanli Xie Chatham University Deepali Malhotra, Ph.D. Unni Krishna Samavedam, Ph.D. University of Minnesota Medical Soochow University Sudipta Das, Ph.D. University of Cincinnati College School University of Pittsburgh School of Medicine Jintao Xu, Ph.D. University of Michigan of Medicine Nurbek Mambetsariev Abigail L. Sedlacek, Ph.D. University of Iowa Carver College Jared L. Delahaye University of Pittsburgh Sudhir Yadav, Ph.D. of Medicine Robert Wood Johnson Medical Center for Infectious Disease Goo-Young Seo, Ph.D. School, Rutgers University Research Laura Mathae La Jolla Institute for Allergy University of British Columbia Adwitia Dey and Immunology Rolando E. Yanes, Ph.D. Stanford University School Pennsylvania State University Pegah Mehrpouya-Bahrami, Ph.D. Kevin Shim University of South Carolina of Medicine Skyla Duncan Mayo Graduate School

Alabama State University Marit Melssen Deann Snyder University of Virginia Allison Ehrlich, Ph.D. Montana State University Oregon State University Andrew S. Mendiola Neetu Srivastava, Ph.D. University of Texas, San Antonio Yanjun Feng State University of New York Upstate Emory University Rabinarayan Mishra, Ph.D. Medical University University of Massachusetts Mayara Fernanda Maggioli, D.V.M. Jenna M. Sullivan Medical School Iowa State University University of Washington Joel T. Finney Lina Sun, Ph.D. Duke University University of Georgia

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS SCHEDULE OF BLOCK SYMPOSIA

FRIDAY, MAY 13 3:45 PM – 5:45 PM Allergic Mechanisms 2:30 PM – 4:30 PM Bacterial and Parasitic Infection and Immunity 2 End Organ Disease in Autoimmunity Cytokines in Immune Regulation Inflammation and Tumor Immunity Immune Regulation at Mucosal Surfaces Lymphocyte Subset Development and Regulation Regulation of CD8 T Cell Activation and Differentiation Metabolic Function in Immune Cells Regulatory Mechanisms of Innate Immune Responses Mucosal Immunity to Bacterial Pathogens Virus-specific T Cell Activation, Differentiation, and Exhaustion MONDAY, MAY 16

8:00 AM – 10:00 AM SATURDAY, MAY 14 Asthma and Airway Inflammation B Cells and Autoimmunity 8:00 AM – 10:00 AM Host Defense and Immune Mechanisms Cellular Immune Responses at the Mucosa Immunosuppressive Mechanisms in Cancer Cytokine Regulation of Immunity to Eukaryotic Pathogens Metabolic and Mucosal Control of Immunity Micro RNAs and RNA Control T Cells in Health and Disease Novel Vaccines/Immunotherapy Protect from Viral and Bacterial Infection 10:15 AM – 12:15 PM T Cells and Therapeutics in Autoimmunity Innate Immune Cells and B Cells in Cancer Molecular Pathways in Autoimmunity 10:15 AM – 12:15 PM Regulation of Immunity at the Lung Mucosa Host-Bacterial Interactions Regulation of T Cell Responses Mast Cells and IgE Metabolism and Immune Regulation in Tumor Therapy 12:30 PM – 2:30 PM T Cell Responses during Acute and Chronic Virus Infections Eukaryotic Host Defenses Immune Responses in Cancer Therapy 12:30 PM – 2:30 PM Molecular Mechanisms of Innate Immunity Antigen Processing and Presentation 1 Novel Therapeutic Mechanisms in Systemic Autoimmunity Innate Cells in Autoimmunity Regulating the Outcome of T Helper Cell Differentiation T Cell Development Regulation of B Cell Responses T Cell Subsets, T Cell Therapy, and Vaccines for Cancer Technological Innovations in Immunology 1 3:45 PM – 5:45 PM Altered Immune Pathways in Disease 3:45 PM – 5:45 PM Cancer Immunotherapy: Novel Strategies and Targets B Cell and CD4 T Cell Responses during Viral Infections Immunity to Viruses Innate Immune Regulation Molecular Basis for Mucosal Vaccines: Novel Strategies and Leukocyte Trafficking Mechanisms Molecular Signatures of Eukaryotic Pathogens Natural Born Killers: A Cytotoxic Approach T Cell Activation: The Early Events Regulatory T Cells Transplantation Immunology Tissue-specific Effects of Cytokines and Chemokines

SUNDAY, MAY 15 TUESDAY, MAY 17 8:00 AM – 10:00 AM Bacterial and Parasitic Infection and Immunity 1 8:00 AM – 10:00 AM Autoimmunity Triggers and Regulation Genetic Dysregulation in Immunodeficiencies and Immune- B Cell Activation and Terminal Differentiation mediated Diseases Checkpoints and Immune Regulation for Tumor Immunity Immune Cell Trafficking and Immune Responses in the Tumor Hematopoiesis and Myeloid Cell Development Inflammation and Disease Novel Regulators of Cytokine Production and Functions Lymphocyte Development, Homeostasis, and Aging Respiratory Viruses and the Host Immune Response The Microbiota and Mucosal Immunity 10:15 AM – 12:15 PM B Cell Development Improving Antitumor Efficacy of T Cells 10:15 AM – 12:15 PM Adoptive Cell Therapy and CAR T cells Inflammation and Infection at Mucosal Surfaces Antigen Processing and Presentation 2 Innate and Cellular Immune Responses to Viruses Consequences of Antigen Recognition by Lymphocytes T Cell Cytokines and Autoimmunity Immunoregulatory Roles for T and B Cell Responses Induced Veterinary and Comparative Immunology by Vaccines/Immunotherapy Inflammasomes 12:30 PM – 2:30 PM Pathogen Control and Evasion Strategies Emerging Treatment Approaches in CNS Autoimmunity Technological Innovations in Immunology 2 Innate Immune Sensing and Signaling www.IMMUNOLOGY2016.org EXHIBITOR COMPANIES (AS OF MARCH 1, 2015)

AAI (The American Association Cellular Technology Limited International Congress of Rockefeller University Press of Immunologists, Inc.) Immunology (ICI) 2016 Chimerigen, Inc. Rockland Immunochemicals Abcam InvivoGen Chondrex, Inc. RURO Inc. ACEA Biosciences, Inc. iRepertoire, Inc. Cloud Clone Corp. Sarstedt, Inc. ACROBiosystems Jackson ImmunoResearch Cyagen Biosciences Inc Science/AAAS Adaptive Biotechnologies Laboratories, Inc. Cytek Biosciences Inc. SCIENION US, Inc. Adipogen Life Sciences JPT Peptide Technologies, Cytobank GmbH Seahorse Bioscience Advanced Targeting Systems DartMouse KRONUS, Inc. Shenandoah Biotechnology, Inc. AID Autoimmun Diagnostika eBioscience, an Affymetrix Sino Biological Inc. GmbH LEINCO TECHNOLOGIES INC business – Gold Sponsor Society for Immunotherapy AimPlex - YSL Bioprocess LifeSensors Elsevier B.V. of Cancer Development Co. List Biological Laboratories, Inc. Embi Tec SoftGenetics AllCells Logos Biosystems, Inc. Enzo Life Sciences, Inc. Sony Biotechnology Inc. – Ancell Corp Lonza Supporting Sponsor Epigentek Group Inc Axis-Shield PoC Lophius Biosciences GmbH Essen Bioscience SouthernBiotech Azure Biosystems Luminex Corporation Springer Silver Sponsor Essential Pharmaceuticals, LLC BD Biosciences – Mabtech, Inc. Expedeon St. Jude Children’s Research Beckman Coulter Life Sciences – MBL International Corporation Hospital Contributing Sponsor FASEB MARC – Gold Sponsor Meridian Life Science, Inc. Stellar Biotechnologies Inc Bio X Cell – Contributing FiberCell Systems, Inc. Sponsor Meso Scale Discovery STEMCELL Technologies Inc. – FlowJo Bronze Sponsor MilliporeSigma (formerly EMD Biocompare Fluidigm Corporation Millipore and Sigma Aldrich) Stratedigm Biocytogen LLC – Silver Sponsor Fred Hutchinson Cancer Studylog Systems Platinum Sponsor BioLegend – Research Center Miltenyi Biotec – Sustaining Sponsor SurModics, Inc. BioMedTech Laboratories, Inc. Freezerworks Sysmex BioPorto Diagnostics A/S Frontiers Myriad RBM Taconic Biosciences Contributing Bio-Rad Laboratories – Garland Science – NanoString Technologies – Contributing Sponsor Sponsor Contributing Sponsor Taylor & Francis The Jackson Laboratory BioreclamationIVT GENE TOOLS, LLC Nature Publishing Group The Journal of Immunology Bioss, Inc. GL Biochem (Shanghai) Ltd. Norgen Biotek Corp. The Lab People, Inc Bio-Techne - R&D Systems, handyem Inc. Novoprotein Silver Novus, Tocris HistoTox Labs, Inc. – PEPperPRINT Thermo Fisher Scientifi c – Contributing Sponsor Sponsor Biovendor PeproTech TissueGnostics USA Boster Biological Technology – Histowiz PerkinElmer Contributing Sponsor Tonbo Biosciences Hycult Biotech Inc. ProImmune Limited BrandTech Scientifi c, Inc. UVP LLC Illumina Inc. Promega Corporation BTS Research VDJServer Immudex USA ProteinSimple Bulldog Bio,Inc. Vector Laboratories Immune Epitope Database & Proteintech Group Inc Caprico Biotechnologies Analysis Resource (IEDB) VitaScientifi c Quad Technologies – CEDARLANE IMMUNOLOGY 2017™ Contributing Sponsor WaferGen Biosystems Washington DC Cell Press Quidel Corporation Worthington Biochemical Corp Innova Biosciences Ltd Cell Signaling Technology RayBiotech, Inc. WuXi AppTec IntelliCyt Corporation – Cellecta Contributing Sponsor ReachBio Research Labs ZenBio, Inc. CELLTREAT Scientifi c Products Research Diets, Inc. Zephyrus Biosciences

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS SATURDAY, MAY 14 comparing SLE, JIA, and sepsis patients to healthy subjects. Join our exhibitor workshop for the presentation of these data and tips Considerations in Determining Targets for Cancer on using the new MILLIPLEX® map Human Complement Panels to Immunotherapy save time, money, and sample, compared to ELISAs.

10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 1 Advancements in Immunotherapeutic Research MilliporeSigma with Magnetic Cell Separation

Presenters: 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 1 Chandra Mohan, Ph.D., Senior Manager, Technical Writing and Miltenyi Biotec Documentation Development, MilliporeSigma, the Life Sciences business of Merck KGaA, Darmstadt, Germany Presenter: Anne Richter, Ph.D., Kevin Long, Ph.D., Senior Manager, Technical & Science Content Research & Development Scientist Marketing, MilliporeSigma, the Life Sciences business of Merck Advancements in cell selection and gene editing have reshaped KGaA, Darmstadt, Germany the reality of immunotherapy. New advances in tissue regeneration Wayne Speckmann, Ph.D., Head of Antibody Development, and effective treatment of cancer and autoimmune diseases MilliporeSigma, the Life Sciences business of Merck KGaA, depend on the further advancement of highly specialized cellular Darmstadt, Germany products. Medical progress is, therefore, dependent on complete and versatile solutions for GMP-compliant cell manufacturing, Antibodies have gained importance as powerful therapeutic including cell separation, differentiation, expansion, formulation, armamentarium for a wide range of human diseases, including and cryopreservation. In order to realize the goal of cellular therapy, many types of cancer. Cancer immunotherapy offers advantages our R&D team members collaborate closely with the world’s leading of high specifi city, fewer side effects, and long-term benefi ts in immunologists to develop unique solutions. This session will some patients. However, it also creates challenges because subtle highlight the work of two extraordinary scientists whose research changes that make cancer cells immortal are not suffi cient enough exemplifi es scientifi c excellence, biomedical innovation, and to elicit an immune reaction. Although the number of therapeutic potential therapeutic impact. options are growing, monoclonal antibodies offer a clear advantage of specifi city and shorter life-span, which limits undesirable side effects. However, there is still need to understand target pathways Cell-based Assays for T cell Metabolism: and develop validated antibodies for research use to fi rst reveal Understanding the Drivers of Immunity appropriately differentiated targets. This presentation will discuss some new research antibodies developed by MilliporeSigma to key 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 2 tumor specifi c antigens that may be valuable in identifying novel Seahorse Bioscience cancer pathway targets. Presenters: Multiplex Assays of Fifteen Human Complement David Ferrick, Ph.D., Chief Scientifi c Offi cer Factors Using New MILLIPLEX® map Panels Kacey Caradonna, Ph.D., Project Manager With all the new information coming out about metabolism driving 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 2 lymphocyte function, the metabolic phenotype of T cells is now MilliporeSigma recognized as a critical piece in the immune response picture. In this workshop you will learn how researchers are using Seahorse Presenter: XF technology to detect metabolic switches that enable T cell Robert Keith, R&D Research Scientist, MilliporeSigma, the Life differentiation and activation, monitor metabolic reprogramming Sciences business of Merck KGaA, Darmstadt, Germany driven by mTOR and other key signaling pathways, and identify The complement system’s multiple plasma proteins assist the metabolic requirements for T cell development and function. phagocytic cells and antibodies in clearing pathogens. The Please join us for this informative session to get practical advice complement system plays a key role in diseases with an immune on designing and performing Seahorse XF metabolic assays with component, such as asthma or sepsis, and in autoimmune T cells, determining which nutrients/substrates are required by diseases, including SLE, IBD, RA, JIA, and MS. Understanding different T cell subsets, and generating and interpreting metabolic how this system affects complex states demands measurement phenotypes of primary immune cells. of multiple proteins simultaneously (“complement profi les”) in patient serum or plasma. Using Luminex xMAP® technology, we developed two multiplex panels to quantitate 15 complement proteins simultaneously in serum or plasma. Signifi cant differences were observed for several complement proteins when

www.IMMUNOLOGY2016.org EXHIBITOR WORKSHOPS

Massively-Parallel Sequencing for Immunology Time to GoInVivo™: Validated Checkpoint and Complex Disease: A Systems Biology Approach Functional Antibodies for Cancer Research with RNA-Seq and Other Methods 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 1 BioLegend Illumina, Inc. Presenter:

Presenter: Miguel A. Tam, Ph.D. , Senior Product Manager Jason Smith, Senior Sequencing Specialist The immune system plays an essential role in controlling tumor The use of next-generation sequencing and epigenetics in biological growth. Tumor cells can communicate with immune checkpoint research can provide unique insights into the mechanisms and receptors to trick the response into suppression, allowing the tumor pathways of complex, multifactorial diseases. To take full advantage cell to grow without immune cell intervention. To interfere with of the increasing capabilities of massively parallel sequencing, a this process, bioactive antibodies can deplete targeted immune holistic approach is needed. The ability to probe the genomics cell populations or block important checkpoint interactions. space from multiple perspectives, including targeted sequencing, Well-studied combinations include PD-1/PD-L1, CTLA-4/CD80 transcriptomics, and epigenetics, unlocks new insights into the and CD86, LAG-3/MHC II, and Tim-3/Galectin 9. BioLegend’s molecular mechanisms of disease. With a single sequencing GoInVivo™ antibodies against immune checkpoint molecules platform, each of these genomics areas can be explored and offer several advantages. They have been validated in both fl ow combined to advance our understanding of complex disease. This cytometry and in vitro bioassays, are pathogen-free as tested by workshop will provide you with an introduction to next-generation qPCR, and have excellent pricing for large sizes. Here we present sequencing technology and to the many applications that are our portfolio, validation methods, as well as in vitro and in vivo possible using next-generation sequencing. Learn about the sample applications. Specifi city is characterized via fl ow cytometry staining to answer solutions to many different applications that Illumina and blocking capacity via target-ligand inhibition bioassays. The offers. Join us for what is sure to be an interesting session! effect of in vitro stimulation and in vivo injection on the activation phenotype and percentage of lymphocytes, as well as the cytokine Development of Immunotherapy Potency Assays profi le are shown. Using Real-Time Cell Analysis and Flow Cytometry The Role of Flow Cytometry in an Advanced Era of

12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 2 Immuno-Therapeutic Discovery ACEA Biosciences, Inc. 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 2

Presenters: Miltenyi Biotec Garret Gunther Presenter: Fabio Cerignoli Matt McBrian, Ph.D., Product Manager Immunotherapy is one of the most promising approaches in cancer Progress in harnessing the power of the immune system is ushering treatment, allowing specifi c elimination of cancer cells through in a new era of immunotherapy. A better understanding of the activation of the immune response. However, despite the necessity immune response and advancements in the manufacture of of in vitro characterization of effi cacy and potency of reagents and genetically-modifi ed immune cells have been critical drivers of protocols before moving to more expensive animal models and this progress. The discovery of effective translational fi ndings relies clinical studies, current in vitro assays are diffi cult to implement strongly on robust and reproducible characterization of the cells in a high throughput environment, are not very quantitative and that mediate the immunological response. Flow cytometry provides are based mainly on end point methods that are unable to capture an effective methodology for this characterization although the the full dynamics of the immune response. In this workshop we standardization of the process can be a challenging endeavor. will present a complete workfl ow that combines the power of This session will demonstrate usage of an innovative platform and xCELLigence real-time cell analysis together with the NovoCyte fl ow reagents from Miltenyi Biotec in the exciting and groundbreaking cytometer for a comprehensive effector-mediated potency assay. work from two labs that illustrate the utility of fl ow cytometry for We will show the validation conducted with antibodies and effector effective cellular characterization utilizing the innovative platform cells such as NK, CTLs, and CART on both solid and liquid tumor and reagents available from Miltenyi Biotec. cell lines. Furthermore, we will also present data that demonstrates how this system could be used for evaluating antibodies in ADCC assays, Bi-specifi c T cell engagers, and checkpoint inhibitors.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS EXHIBITOR WORKSHOPS

SUNDAY, MAY 15 Leveraging 3D Biology for Development of Cancer Immuno-Oncology/Immuno-Therapy Biomarkers Multiplex-microarray Immunoassays and the - Simultaneous Digital Counting of Nucleic-Acids Serological Confirmation of Chagas Disease and Proteins at 800-plex

10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 1 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 1 SCIENION US, Inc. and InfYnity Biomarkers NanoString Technologies

Presenters: Presenter: TBD Claude Dufresne, President Maan Zrein, CEO, InfYnity Biomarkers The ability of mutated cells to give rise to cancer relies upon the ability to evade immune recognition, suppress immune activity, Elodie Granjon, Chargée de recherche, InfYnity Biomarkers and persist in a chronically infl amed environment. NanoString Immunoassays are usually performed in 96-well plates, with has developed an all-digital 3D technology for cancer immune- each well coated with a single mixture of antibodies or antigens, profi ling by simultaneously measuring 770 mRNAs (from 24 resulting in a single data point. Multiplexed assays involve both infi ltrating immune cell types plus numerous immune-signaling miniaturization and the measure of multiple analytes. Instead of pathways) plus 60 key immune system-associated proteins (cell a single reactant covering the well bottoms, an array of different surface markers, immune checkpoints, cytokines, chemokines, etc.) molecules is ‘printed’ and immobilized. Multiple measurements are in small amounts of clinically relevant samples. This technology then obtained from a single well. Advantages include reductions forms the basis for multi-year collaborations between NanoString in reagent usage, turn-around time and sample consumption. and MD Anderson Cancer Center and the Cancer Immunotherapy This workshop illustrates multiplexing using an innovative Trials Network (CITN) to discover multi-analyte-type (mRNA + implementation by SCIENION and InfYnity Biomarkers. Using protein) biomarker signatures to guide cancer immunotherapy. In antigen arrays, antibody-profi ling responses can be performed this session, NanoString will present hidden biological information versus hundreds of antigens in a single assay. Such high-throughput locked in DNA, RNA and protein. studies have uncovered new antigenic targets, new insights into vaccine research and into immunoreactivity against most of the Molecular Profiling of Tumor Microenvironment proteome of some pathogens. This response pattern is often Using CancerNet Targeted NGS Panel associated with a clinical infection, such as Chagas.

Quantitation of MCHII Trafficking Using Imaging 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 2 Cellecta in Flow Presenters: 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 2 Sunitha Sastry, Ph.D., Senior Product Manager MilliporeSigma Alex Chenchik, Research Director

Presenters: The clinical importance of tumor immune infi ltrates has been Sherree Friend, Ph.D., Product Manager, Amnis®, MilliporeSigma, an emerging area, particularly in triple negative breast cancer the Life Sciences business of Merck KGaA, Darmstadt, Germany (TNBC) where increased immune infi ltrate predicts both response to chemotherapy and improved survival. To this end, we have Edith Janssen, Ph.D., Cincinnati Children’s Hospital Medical developed CancerNet, a comprehensive targeted RNA-Seq cancer Center immuno-panel that profi les ~2,000 genes and distinguishes 37 Imaging fl ow cytometry applies the speed, sensitivity, and human hematopoietic cell phenotypes (including naïve and phenotyping abilities of fl ow cytometry with the detailed imagery memory B cells, seven T-cell types, dendritic cells, plasma cells, and functional insights of microscopy to address complex inquiries natural killer (NK) cells and myeloid subsets), genes involved in in immunology. In this workshop, you will learn how Amnis® checkpoint blockade and immunotherapy biomarkers, immune cell imaging fl ow cytometers have been used to examine the traffi cking activation, and canonical immune pathway genes. The assay panel of MHC class II (MHCII) in dendritic cells. The abundance of characterizes the cellular composition of the immune/stromal/ antigenic peptide-MCHII complexes on antigen presenting cells is cancer cell tumor microenvironment and determines the activation determined by many factors that include the balance between the status of infi ltrating immune cells in primary tumor tissues expression of newly generated complexes, complex internalization from TNBC patients. Preliminary data demonstrate the assay’s and subsequent re-emergence or degradation. However, the unparalleled specifi city and sensitivity as well as an improved cost- molecular mechanisms that govern these interactions are still effectiveness for high-throughput clinical Next-Gen applications. poorly understood. Here, we discuss how multispectral imaging in fl ow can be used to visualize MHCII traffi cking and elucidate the molecular mechanisms that regulate MHCII homeostasis in primary mouse and human dendritic cells. www.IMMUNOLOGY2016.org EXHIBITOR WORKSHOPS

Accelerating Innovation with Immunosequencing MONDAY, MAY 16 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 2 Optimize your ELISA and Multiplex Immunoassays Adaptive Biotechnologies Corporation for Sensitive and Reliable Results Presenter: 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 1 Catherine Sanders, Director, Scientifi c Liaison Abcam Adaptive Biotechnologies’ commercial products combine the capabilities of a multiplex PCR with high-throughput sequencing Presenter: and a sophisticated bioinformatics pipeline to profi le T cell and B Russell Neuner, Senior Scientist cell receptor repertoiResearch This unprecedented capability is complemented by powerful analytical software tools that facilitate Optimization strategies for ELISA and multiplex immunoassays to analysis, visualization, comparison and reporting of TCR or BCR achieve sensitive, specifi c and accurate quantifi cation of biomarkers sequence data. Adaptive’s immunoSEQ assay is applicable in will be discussed. These strategies are critical for the use of assays various fi elds, including autoimmunity, infectious disease, allergy, in research and also in assay development. Many commercial oncology, drug development, and transplantation. Come and learn assay kits perform with high sensitivity and a broad dynamic range how immune profi ling can be applied to your research. using purifi ed proteins but fail to perform in experimental sample types. Development of robust assays using matched antibody pairs can fail if the right steps are not taken. Strategies that will be Time to GoInVivo™: Validated Checkpoint discussed, include how to: titrate antibody pairs to improve signal Functional Antibodies for Cancer Research to noise, formulate diluents to alleviate matrix effects, calibrate protein standards and validate for antibody pair cross-reactivity. 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 Key fundamentals for use of ELISA and multiplex immunoassays BioLegend will also be addressed, including how to optimize sample dilutions based on your sample type, control for matrix effects, normalize for

Presenter: batch variability, and test for recovery and linearity of dilution. Miguel A. Tam, Ph.D. , Senior Product Manager The immune system plays an essential role in controlling tumor Accelerating Immuno-oncology and Antibody growth. Tumor cells can communicate with immune checkpoint Discovery Research Through Large Scale Profiling receptors to trick the response into suppression, allowing the tumor of Suspension Cells Using the iQue Screener cell to grow without immune cell intervention. To interfere with Platform this process, bioactive antibodies can deplete targeted immune cell populations or block important checkpoint interactions. 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 2 Well-studied combinations include PD-1/PD-L1, CTLA-4/CD80 IntelliCyt Corporation and CD86, LAG-3/MHC II, and Tim-3/Galectin 9. BioLegend’s GoInVivo™ antibodies against immune checkpoint molecules Presenters: offer several advantages. They have been validated in both fl ow David Sykes MD. PhD., cytometry and in vitro bioassays, are pathogen-free as tested by Researcher at the Broad Institute qPCR, and have excellent pricing for large sizes. Here we present Markus Vähä-Koskela, Ph.D., Senior Researcher at FIMM (Institute our portfolio, validation methods, as well as in vitro and in vivo for Molecular Medicine Finland) applications. Specifi city is characterized via fl ow cytometry staining IntelliCyt offers an integrated solution that enables simultaneous and blocking capacity via target-ligand inhibition bioassays. The screening of cells and secreted proteins in suspension for maximum effect of in vitro stimulation and in vivo injection on the activation insight into complex biology. Our iQue Screener platform is a phenotype and percentage of lymphocytes, as well as the cytokine benchtop instrument, software, and reagent system that optimizes profi le are shown. the entire workfl ow to deliver the fastest time to results. Use of the lowest volume assays provides rich and insightful data in minutes. Two end-users will highlight how IntelliCyt’s high throughput approach to assay phenotypic endpoints enabled them to identify compounds for myeloid differentiation and large scale anti- myeloma drug screening.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS EXHIBITOR WORKSHOPS

Unexpected Roles for Intracellularly-Operating and gradient formation, and can be paired with a microscope Innate Immune Networks in Human Th1 for dynamic live-cell imaging. Together, these platforms enable Responses – Do We Need to Think ‘Outside the Box’ functional profi ling of single immune cells with unparalleled and ‘Inside the Cell’? control and sensitivity.

11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 1 Fast and Easy Isolation of Highly Pure Unique Hycult Biotech Inc Immune Cell Subsets Using EasySep™ Release

Presenters: 12:30 PM-1:15 PM EXHIBITOR WORKSHOP ROOM 2 Claudia Kemper, Ph.D., Trust Investigator/ Professor of Innate STEMCELL Technologies Inc. Immunology, MRC Centre for Transplantation, King’s College

London Presenters: Andy Kokaji, Ph.D., Erik Toonen, Ph.D., R&D Scientist Senior Scientist Hannah Lee, Ph.D. For a long time, studying the adaptive immune system has been , Senior Product Marketing Manager central in the design of therapeutics. New insights indicate that The isolation of unique immune cell subsets is often diffi cult and complement activation also regulates fundamental processes of the time-consuming. Explore how to easily and quickly isolate your cell, such as metabolic activity and homeostasis. It also serves as a non-standard subset of cells using the new EasySep™ Release nexus for the interaction with other effector systems. Specifi cally, an cell isolation products by STEMCELL Technologies. EasySep™ intracellular complement/NLRP3 infl ammasome crosstalk emerges Release is an immunomagnetic, column-free cell isolation platform as critical for normal IFN-g secretion by T cells. Advancing insights featuring a rapid, no-wash and gentle method for the removal of have not only shown that innate immune regulators are present but magnetic particles on positively-selected cells. EasySep™ Release are also key in directing immunological responses. This is of great cell isolation products can be used sequentially with our extensive signifi cance to our understanding of the biology of immune cells portfolio of positive- or negative-selection EasySep™ kits to create and immune system evolution. It also helps explain why targeting endless antigen-targeting combinations for the isolation of your just one arm of the immune system is insuffi cient for disease unique immune cell types. The workshop will describe different treatment. This workshop will give an overview of the emerging applications and cell types that use EasySep™ Release cell isolation key roles of autocrine complement activity in the regulation of Th1 products for the fast and easy isolation of highly purifi ed unique responses and then invites discussion about their implications for immune subsets. design of next generation therapeutics and monitoring. Detection Sensitivity Is Enhanced by More Powerful Tools to Enhance, Streamline and Powerful Lasers and Expanded Optical Simplify Dynamic Single Cell Analysis of Immune Configurations in a Benchtop Flow Cytometer Function 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 2 MilliporeSigma MilliporeSigma

Presenter: Presenters: Katherine Gillis, Amedeo Cappione, Ph.D., Senior Scientist, MilliporeSigma, the Life Sciences Senior Scientist, MilliporeSigma, the business of Merck KGaA, Darmstadt, Germany Life Sciences business of Merck KGaA, Darmstadt, Germany Paul Ju-Sung Hung, Ph.D., Multilaser fl ow cytometers with the capacity for simultaneous R&D Manager, MilliporeSigma, the Life measurement of suffi cient targets for immunological analysis Sciences business of Merck KGaA, Darmstadt, Germany have traditionally required extensive operator expertise and are Precise regulation of lymphocyte function is critical to mounting a often housed in select or shared labs due to cost. Guava® easyCyte specifi c immune response; this complex process requires exquisite systems offer four enhanced-power modulated lasers, including control over cell migration and expression of effector capabilities. a unique 532 nm green excitation laser, in a benchtop instrument Understanding these mechanisms is essential for development priced for accessibility by individual labs. The microcapillary of therapeutics that enhance endogenous immune function. The fl uidics employed by all Guava® systems uniquely enable absolute ELISpot assay offers quantitative assessment of effector function(s) cell counts with small sample volumes in single tube or 96-well at the single cell level with superior sensitivity. MilliporeSigma plate format, rendering them ideally suited for precious biological and collaborators have signifi cantly improved the venerable samples from patients or transgenic models. The Guava® InCyte but tricky ELISpot technology with advanced membrane plates, software includes a heat map view of high-throughput plate results, multiparameter fl uorescent reporting (fl uorospot), and optimized making simultaneous visualization of multiple parameters possible protocols. Cell migration models suffer from the inability to and permitting assessment of multisample activation, synapse establish continuous gradients and are not amenable to real-time formation, and other immunomodulation in a single view. Data will studies. The microfl uidic-based ONIX cell culture system offers be shown demonstrating how signal from up to twelve fl uorophores real–time environmental control, including media perfusion can be accurately resolved for autoimmunity studies, immunogenic/ tolerogenic responses, and intracellular immune activity. www.IMMUNOLOGY2016.org Important Dates for Two AAI Awards Programs

AAI Programs to Benefit Your Lab’s Current or Future Research

AAI Careers in AAI Travel for Techniques Immunology Fellowships Award Program

KEY DATES APPLICATIONS OPEN APPLICATIONS CLOSE AWARDS CYCLE APPLICATIONS OPEN APPLICATIONS CLOSE JANUARY 15 MARCH 15 WINTER DECEMBER 15 FEBRUARY 15 SPRING APRIL 15 JUNE 15 These fellowships provide AAI member PIs with one year of FALL AUGUST 15 OCTOBER 15 salary support for a graduate student or postdoctoral fellow in their labs. Member PIs in good standing with less than The Travel for Techniques Award is given to member PIs, $250,000 (excluding PI’s salary) in annual direct costs are reimbursing up to $1,500 in expenses for travel to learn eligible to apply. a new technique. Member PIs in good standing with less Consideration is based on the merit of the PI’s proposed project, than $250,000 (excluding PI’s salary) in annual direct costs potential of the trainee, and quality of the training environment. are eligible to apply. Direct inquiries to [email protected]. Direct inquiries to [email protected].

These two exciting awards programs were launched by The American Association of Immunologists in 2014, adding significantly to its already robust support for scientists through fellowships, career awards, and travel grants. For more information, visit www.aai.org/awards. IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 2016 Introductory Course in Immunology July 9–14, 2016 • Long Beach Convention Center, Long Beach, California Director: Juan Carlos Zuñiga-Pflücker, Ph.D. University of Toronto and Sunnybrook Research Institute

Don’t miss the most comprehensive introduction to immunology available! This intensive two-part course, taught by world-renowned immunologists, provides a comprehensive overview of the basics of immunology. This course is for students new to the discipline or those seeking more information to complement general biology or science training. Part I (July 9–11) is a detailed introduction to the basic principles of immunology and is suitable for students with a general biology background. Part II (July 12–14) is a clinically oriented lecture series focusing on specialty areas. Parts I and II may be taken independently at the discretion of the student. Faculty Juan Carlos Zuñiga-Pflücker, University of Toronto Stephen M. Hedrick, University of California, and Sunnybrook Research Institute San Diego Introduction to the Immune System Host-Pathogen Co-evolution in Human Beings: the Red Queen and the Grim Reaper Lewis L. Lanier, University of California, San Francisco Innate Immunity: Introduction to the Cells David C. Parker, Oregon Health and Science University T and B Cell Tolerance Deborah A. Fraser, California State University Matthias G. von Herrath, La Jolla Institute for Allergy Long Beach and Immunology Complement Autoimmunity Helen S. Goodridge, Cedars-Sinai Medical Center Olivia M. Martinez, Stanford University School Innate Immunity: Introduction to Pattern of Medicine Recognition and Intracellular Signaling Transplantation Wendy L. Havran, The Scripps Research Institute Peter B. Ernst, University of California, San Diego Introduction to Adaptive Immunity Mucosal Immunology Nilabh Shastri, University of California, Berkeley Marion Pepper, University of Washington Antigen Processing and Presentation Type 2 Immunity Juan Carlos Zuñiga-Pflücker, University of Toronto Linda A. Sherman, The Scripps Research Institute and Sunnybrook Research Institute Tumor Immunology MHC Restriction and Thymic Selection Robert L. Modlin, University of California, Los Angeles David Nemazee, The Scripps Research Institute David Geffen School of Medicine B Cell Development and Maturation Immunity to Bacterial Pathogens Shannon J. Turley, Genentech, Inc. Steven M. Varga, University of Iowa Dendritic Cells: The Bridge Between Innate Immunity to Viruses and Adaptive Immunity Martin Prlic, Fred Hutchinson Cancer Research Center Michael Croft, La Jolla Institute for Allergy Immunologic Memory and Immunology Effector T Cell Differentiation and Response Nicole Frahm, Fred Hutchinson Cancer Research Center Vaccination Shane Crotty, La Jolla Institute for Allergy and Immunology Jennifer M. Puck, University of California, B Cell Activation and Humoral Immunity San Francisco Arthur Weiss, University of California, San Francisco Genetic Approaches to Immune-Mediated Diseases Signaling in the Immune System Andrew C. Chan, Genentech, Inc. Wenjun Ouyang, Amgen Bench to Bedside to Bench: Current Issues Cytokines in Immunology

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html. 2016 Advanced Course in Immunology July 31–August 5, 2016 • Seaport World Trade Center, Boston, Massachusetts Director: Ulrich H. von Andrian, M.D., Ph.D., Harvard Medical School

Don’t miss the premier course in immunology for research scientists! This intensive course is directed toward advanced trainees and scientists who wish to expand or update their understanding of the field. Leading experts will present recent advances in the biology of the immune system and address its role in health and disease. This is not an introductory course; attendees will need to have a firm understanding of the principles of immunology. Faculty Ulrich H. von Andrian, Harvard Medical School Leslie J. Berg, University of Massachusetts Anatomy of the Immune Response Medical School Signaling from Antigen Receptors Jonathan C. Kagan, Children’s Hospital Boston Harvard Medical School Stephen C. Jameson, University of Minnesota Center Innate Immunity: Pattern Recognition and for Immunology Anti-microbial Mechanisms T Cell Memory Bruce Horwitz, Brigham & Women’s Patrick C. Wilson, University of Chicago Hospital, Harvard Medical School B Cell Memory Innate Immunity: Gene Regulation Arup K. Chakraborty, Massachusetts Institute Albert S. Bendelac, University of Chicago of Technology Innate Immunity: Cellular Mechanisms Computational Modeling of Immunological Wayne M. Yokoyama, Washington University School Processes of Medicine Brian A. Cobb, Case Western Reserve University NK Cells — Their Receptors and Function in School of Medicine Health and Disease Glycoimmunology Michael C. Carroll, Immune Disease Institute Richard S. Blumberg, Brigham & Women’s Harvard Medical School Molecular and Cellular Mediators Hospital, Harvard Medical School of Inflammation Mucosal Immunity Brian T. Edelson, Washington University School Joel D. Ernst, New York University School of Medicine of Medicine Dendritic Cells Immune Response to Pathogens Eugene M. Oltz, Washington University School Vijay K. Kuchroo, Brigham & Women’s Hospital, of Medicine Harvard Medical School The Generation and Modification of Lymphocyte T Cell Tolerance and Autoimmunity Antigen Receptor Genes Kevin J. Tracey, Feinstein Institute for Medical Research Kay L. Medina, Mayo Clinic Neuroimmunology B Cell Development Lisa H. Butterfield, University of Pittsburgh Avinash Bhandoola, NCI, NIH Tumor Immunology T Cell Development Dennis W. Metzger, Albany Medical College Kenneth L. Rock, University of Massachusetts Vaccines Medical School Also included will be lectures on: MHC-Restricted Antigen Presentation to T Cells B Cell Tolerance and Autoimmunity Immunotherapeutics

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html.

IMMUNOLOGY 2016™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS A Century of Excellence

Comprehensive • Authoritative • Foundational

AI proudly celebrates the 2016 centennial of During this milestone year, AAI is featuring on the AThe Journal of Immunology (The JI), the largest and journal website several fun and informative articles on oldest journal in the field. the history of The JI – visit http://www.jimmunol.org/ Today, The JI offers unparalleled reporting on site/misc/Centennial/Centennial-TOC.xhtml. With major advances in immunology research in all areas additional articles to be added throughout the year, items of experimental immunology, including currently available include: • Innate and adaptive immunity • Founding The Journal of Immunology • Inflammation • Publications of Nobel Laureates in The JI • Host defense • 100 Most Cited Articles in The JI • Clinical immunology, • Editors-in-Chief, Past and Present • Autoimmunity, and more. • The JI Articles Featured in Pillars of Immunology Special sections include Cutting Edge articles, Brief Visit http://www.jimmunol.org/site/misc/Centennial/ Reviews and Pillars of Immunology. Centennial-TOC.xhtml in the months ahead to view additional articles as they become available. The JI publishes novel findings that are fully peer- reviewed, rapidly published, and broadly cited, making it the working scientist’s “first stop” for keeping up with major advances in all areas of experimental immunology. The three-tier review process practiced by The JI ensures a fair, in-depth evaluation of each paper. Yet the time from submission to first decision is, on average, less than 29 days and publication online follows acceptance in just four weeks. The JI is cited more than any other immunology journal, and, at 8.6 years, the citation half-life of The JI is one of the longest of any journal in the field, indicating that the content is of enduring relevance and importance to the field. AAI thanks the more than 3,000 practicing immunologists who review manuscripts for The JI each year in a conscientious and objective manner. All reviewers and editors of The JI are committed to publishing research that is rigorously performed and moves the field forward. The continued high quality of The JI depends upon the dedicated service of all of these individuals.

www.IMMUNOLOGY2016.org The American Association of Immunologists Future AAI Annual Meetings Mark Your Calendar for the Premier Annual Immunology Event!

2016

IMMUNOLOGY 2016™ May 13–17 Seattle, Washington 2017

IMMUNOLOGY 2017™ May 12–16 Washington, D.C.

2018

IMMUNOLOGY 2018™ May 4–8 Austin, Texas