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DEPARTMENT OF MEDICINE

BI-ANNUAL REPORT I ACADEMIC YEARS 2003 & 2004 BI-ANNUAL REPORT I CDMCYAS20 2004 & ACADEMIC YEARS 2003

Patient Care, Teaching & Research

Rhode Island Hospital/Hasbro Children’s Hospital Rhode Island Hospital/Hasbro Children’s Hospital The Miriam Hospital The Miriam Hospital Memorial Hospital of Rhode Island Memorial Hospital of Rhode Island Women & Infant’s Hospital Veteran’s Administration Medical Center Women & Infant’s Hospital

Veteran’s Administration Medical Center Department of Medicine Administrative Offices Rhode Island Hospital Main Building, 1st Floor 593 Eddy Street Providence, RI 02903

WWW.BROWNMEDICINE.ORG BROWN UNIVERSITY, PROVIDENCE, AND NEW ENGLAND

rown University, Providence and Rhode On the Brown campus are plays, concerts, Island together provide a pleasant and movies, lectures, art exhibits and many other Binteresting setting for study, recreation, sources of entertainment and intellectual The Department of Medicine’s 2003 & 2004 and daily life. From atop College Hill the stimulation throughout the year. A modern Bi-Annual Report was produced by: University overlooks downtown Providence, athletic complex within easy walking distance Denise Lavely-O’Hara the capital of Rhode Island and the second from the main campus offers swimming in a Design largest city in New England. The University modern Olympic-sized pool, extensive exercise Mary Norris was founded in 1764; its architecturally diverse equipment, squash and tennis courts, and Brown Graphics, Brown University buildings and quadrangles center on the ice-skating, as well as playing fields and facilities Printing original College Green. In the surrounding for intramural and varsity team sports. Brown Graphics, Brown University residential area are many houses that date back Rhode Island is especially known for recreational Photography to colonial times, together with various historic opportunities centered on the ocean and Constance Brown sites, including the Old State House, where Rob Pike Narragansett Bay, including boating, fishing, Len Rubenstein independence in America was first declared, sailing and swimming. Newport, the site of Women & Infant’s Hospital Media Center and the First Baptist Meeting House, the oldest some of the nation’s most magnificent Special thanks to the following Baptist Church in America. for their contributions: mansions and for many years home of the Theresa Bomba Contemporary life in Providence complements America’s Cup sailing races, is less than an Daniel Bryant the city’s interesting history. One can walk from hour away. Providence is an hour by car, bus Tonda Cunha Maria Darocha the campus to any of a variety of restaurants, or train from Boston, an hour from Cape Cod, James Florio to the nationally renowned Trinity Square about three hours from major New Hampshire Patricia O’Hara The Department of Medicine Division Repertory Theater or a performance of the and Vermont ski areas, and three-and-one-half Director’s Secretarial Staff Rhode Island Philharmonic Orchestra, or to a hours from New York City. At T.F.Green jazz club or dance performance. Attractions Airport, ten minutes from downtown also include several art galleries, including the Providence, several major airlines offer museum of Brown’s college hill neighbor, the frequent service to all major points in the Rhode Island School of Design. United States. Department of Medicine

BI-ANNUAL REPORT I ACADEMIC YEARS 2003 & 2004

Rhode Island Hospital/Hasbro Children’s Hospital The Miriam Hospital Memorial Hospital of Rhode Island Women & Infant’s Hospital Veteran’s Administration Medical Center

Q Introduction and Overview Comments from the Chairman...... 2 Department of Medicine Organization ...... 3–4

Q Division Highlights Cardiology ...... 5 Endocrinology ...... 23 Gastroenterology ...... 32 General Internal Medicine...... 44 Geriatrics...... 69 Hematology/Oncology...... 75 Hospitalist Medicine ...... 91 Infectious Disease...... 93 Nephrology ...... 129 Obstetric & Consultative Medicine...... 139 Pulmonary, Critical Care & Sleep Medicine...... 145 Rheumatology ...... 162

Q International Health at Brown ...... 165

Q Grand Rounds ...... 167

Q Clinical Activity ...... 176

Q Research Activity ...... 177

Q Brown Affiliated Hospitals ...... 178

Q Brown, Providence & New England ...... back cover 1 introduction and overview

Edward J. Wing, M.D. is the Chairman of Medicine and Joukowsky Family Professor of Medicine at Brown Medical School and for its’ five affiliated hospitals. He serves as Physician-in-Chief at Rhode Island Hospital and The Miriam Hospital and Executive Physician-in-Chief at Memorial Hospital of Rhode Island, Women & Infants Hospital and the Veterans Affairs Medical Center. Dr. Wing is the Director of the Internal Medicine Residency Program at Rhode Island Hospital, The Miriam Hospital and the VAMC. Dr. Wing graduated from Harvard Medical School and completed his internship and residency at the Peter Bent Brigham Hospital in Boston, Massachusetts. Comments from the Chairman He completed an Infectious Disease Fellowship at Stanford University. ince the last Department of Medicine bi-annual review (2001-2003), the Department has continued to expand and succeed in its educa- Dr. Wing joined the faculty at the University of Pittsburgh where he rose tional, clinical, and research programs. Over the past two years we S to Professor of Medicine. He served have hired nearly sixty faculty as a result of these growing activities. variously as Physician-in-Chief at New clinical programs include the Hallett Diabetes Center, which sees Montefiore Hospital, Chief of Infectious over 8,000 visits per year under the leadership of Dr. Bob Smith. This Diseases at the University of Pittsburgh and Interim Chief of Medicine before Center represents a new specialty resource for patients in Rhode Island coming to Brown in 1998. as well as an important part of the educational and research programs at the Brown Medical School. The Gastroenterology Division has expanded Dr. Wing’s research interests have its clinical and research activities markedly. Cardiology, under the new focused on the immune host defenses against intracellular pathogens such as leadership of Dr. Al Buxton has reorganized its structure and now Listeria monocytogenes and agents of includes more than 35 faculty. Within the last year outstanding bio-terrorism. He also has a strong clinical researchers in molecular cardiology have been hired from the Harvard interest in infectious diseases, HIV, and system promising an exciting new research program. international health. The Department of Medicine is responsible for approximately 40% of all teaching at the Brown Medical School. The training programs in the Department total 180 residents in Categorical, Primary Care, Med/Peds, and Preliminary tracks. We also have 75 fellows in all subspecialty areas. Each of these programs attracts outstanding students and trainees from around the country. Research continues to grow and as of 2004 accounts for greater than 35 million dollars in total annual expenditures. The total portfolio is approximately 247 million dollars. More than 75% of this is federal funding. Finally, our international programs have literally blossomed in the last five years. We have vigorous research and clinical programs in Kenya at the MOI University, Faculty of Health Sciences, a program in HIV and care prevention in Chennai, India affiliated with the University of Madras, and a growing program in Cambodia. These programs are supported by Fogarty grants. Similarly, new programs in the Dominican Republic have been developed in the past year, as well as a brand new program in Amman, Jordan. These programs account for an important portion of our research portfolio as well as providing international clinical experiences for our students, residents, fellows, and faculty. In total, these programs have become one of the exciting hallmarks of the Department. This Departmental review highlights some of the changes and growth in the Department. We welcome any feedback that you have. September 25, 2005 2 brown medical school department of medicine

Office of the Chairman Edward J. Wing, MD Chairman of Medicine and Joukowsky Family Professor of Medicine, Physician-in-Chief, Rhode Island Hospital and The Miriam Hospital Frederick Schiffman, MD Professor, Vice Chairman, The Miriam Hospital Dominick Tammaro, MD Associate Professor, Associate Chief for Clinical Affairs Rhode Island Hospital Peter J. Ceriani, MBA Administrator, Rhode Island Hospital & The Miriam Hospital Denise Lavely-O’Hara Internal Medicine Graduate Med. Ed. Administrator Daniel Bryant Research Administrator, Rhode Island Hospital & The Miriam Hospital Patricia O’Hara Administrative Coordinator Jean Drinan Administrative Secretary

Division Division Chief

Cardiology Alfred Buxton, MD

Endocrinology Robert Smith, MD

Gastroenterology Jack Wands, MD

General Internal Medicine Michele Cyr, MD

Geriatrics Richard Besdine, MD

Hematology/Oncology Edward Wittels, MD Alan Rosmarin, MD

Hospitalist Medicine Sajeev Handa, MD

Infectious Disease Timothy Flanigan, MD

Nephrology Lance Dworkin, MD

Obstetric & Consultative Medicine Karen Rosene-Montella, MD

Pulmonary, Critical Care & Sleep Medicine Sidney Braman, MD

Rheumatology Edward Lally, MD DEPARTMENT OF MEDICINE ORGANIZATION DEPARTMENT

3 introduction and overview

DEPARTMENT OF MEDICINE FACULTY # THROUGH JUNE 30, 2005

TOTAL 498 Full-Time 227 Volunteer 239 Adjunct 32

Faculty by Division DIVISION FULL-TIME # CLINICAL ADJUNCT Cardiology 35 35 3 Endocrinology 13 7 2 Gastroenterology 16 24 0 General Internal Medicine 53 107 2 Geriatrics 7 0 0 Hematology/Oncology 29 15 6 Hospitalist 0 10 0 Infectious Disease 33 4 11 Nephrology 11 16 0 Obstetrics & Consultative Medicine 5 3 0 Pulmonary, Critical Care 23 15 3 & Sleep Med. Rheumatology 2 3 5 TOTAL 227 239 32 Faculty by Hospital HOSPITAL FULL-TIME CLINICAL ADJUNCT Memorial 18 42 1 Miriam 46 70 7 Rhode Island 145 90 14 Roger Williams 0 9 9 St. Joseph’s 0 1 0 VAMC 12 18 1 Women & Infants 6 6 0 Kent* 0 3 0 TOTAL 227 239 32

*Only in GIM #Hospital or Foundation Based

4 brown medical school department of medicine

CARDIOLOGY OVERVIEW

rom 2003 to 2005 the Cardiology Division at Brown Medical School underwent significant Fchanges in structure. Alfred Buxton was appointed Director of the Division in August, 2004. The admin- istrative structure of the Division has evolved over the past two years in order to maximize the strengths of the individual components of the Division at the VA Hospital, the Miriam and Rhode Island Hospitals. The Cardiology fellowship program is under a new program director, Dr. James Arrighi, who joined the faculty in September, 2004. Dr. Arrighi previously directed the cardiology fellowship at Yale University. The Cardiology Fellowship Programs at Rhode Island and Miriam Hospitals united for the first time with the class beginning July 2004. The combined program is now in its second year utilizing 3 hospitals: Rhode Island Hospital, Miriam Hospital, and the Providence VAMC. This combination creates a rich environment for training, with unparalleled breadth and opportu- nity. Over 30 faculty members, covering all areas of Alfred Buxton, MD, Professor of Medicine; cardiology, participate in training of our fellows. The Director, Division of Cardiology Division of Cardiology is dedicated to excellence in geographic components of the Division in a highly teaching and research, maintains a scholarly academic successful manner. By all reports from fellows and atmosphere, and ensures a wide exposure to all aspects faculty, this restructuring of the fellowship is a success of cardiovascular medicine. We are committed to the story in its early stages. personal growth and development of each fellow as an In addition to the clinical cardiology fellowship the individual, and strive towards constant improvement Division also is home to two accredited interventional in the training environment. Input from fellows is fellowship programs, located at Miriam and Rhode critical in maintaining a dynamic, positive program. Island Hospitals, as well as a clinical electrophysiology The clinical fellowship program includes 6 trainees per fellowship that covers Miriam and Rhode Island year for a minimum of three years. The first 2 years are Hospitals. Each of the interventional fellowships is a dedicated to mastering the core aspects of clinical one year program, and each comprises two fellows at cardiology, and are comprised of required rotations in this time. The clinical cardiac electrophysiology train- each of the major disciplines of Cardiology (consulta- ing program covers two years, and includes a total of tive and diagnostic cardiology, noninvasive imaging, four fellows. heart failure, electrophysiology, and catheterization). A major goal of the Cardiology Division is to provide The third year is tailored to the individual’s career goals. complete integrated cardiac services across the entire Participation of fellows in a research experience within range of Brown Medical School affiliated institutions. the Division and Department is expected, and provides Following the example of the Cardiac fellowship, the a foundation of ongoing scholarship and critical clinical cardiac electrophysiology service provides thinking that is required for any career in medicine. The campus wide services including Miriam and Rhode program is very competitive, and attracts candidates of Island Hospitals. In the near future the electrophysiol- the highest caliber. For the most recent match, ogy service will also provide services at the approximately 500 applications were received for the 6 Providence Veteran’s Administration Hospital. The open positions. Division also plans to expand its heart failure and This evolution of the Cardiology fellowship program rehabilitation/primary prevention programs across has resulted in renewed interaction between the various the medical system. 5 cardiology

Major initiatives in the Cardiology Division include year, utilizing the most state-of-the-art techniques. All provision of newer imaging techniques. Dr. Michael scans are performed using a unique technology, called Atalay of the Radiology Department provides high attenuation-correction, which helps to improve the level cardiac magnetic resonance imaging services. accuracy of studies and reduce the chance of falsely In collaboration with members of the Cardiology abnormal studies. The laboratory maintains a database, Division, initiatives are being undertaken for evaluation and is actively involved in clinical research. of patients with sarcoidosis for sudden death risk The laboratory also is involved in clinical research using magnetic resonance imaging. Magnetic projects in several areas. Several new imaging agents Resonance Imaging is beginning to be used to explore will be investigated as part of multicenter trials over the anatomic basis for ventricular tachyarrhythmias the next several years. One agent, called MIBG, is used in patients with coronary disease and nonischemic to assess innervation of the heart. Its utility in assessing dilated cardiomyopathies. The magnetic resonance the prognosis of patients with heart failure will be imaging services are provided at both the Miriam and assessed. Another agent, called BMIPP, is used to Rhode Island Hospitals. assess myocardial ischemia, and will be evaluated in At Rhode Island Hospital, the opening of the new patients presenting with chest pain. In another study, emergency room has been accompanied by an expanded imaging the vascular system will be attempted using a role of cardiology in the emergency room. An eight bed compound called FDG, which is a glucose analog. cardiac unit has been established in order to provide Dr. Peter Tilkemeier continues to direct nuclear screening services for patients with chest pain syndromes. cardiology at The Miriam Hospital. The clinical Patients with cardiac arrhythmias will also be evaluated nuclear laboratory at The Miriam Hospital, and the in this newly opened unit. Incorporated in this unit is a new imaging center at Collyer Street, are busy clinical noninvasive testing facility including treadmill and facilities, processing more than 2500 studies yearly. echocardiogram evaluations. Under construction at this The nuclear laboratory functions as an integral part time in coordination with the new emergency room is a of the clinical cardiology fellowship training program. state-of-the-art cardiac catheterization laboratory. This laboratory, scheduled to open in the winter of 2006, will The heart failure program, under the direction of Dr. accelerate the provision of catheterization services to Daniel Levine has been very active. The first ventricular patients with acute coronary syndromes. assist device (VAD) was implanted recently. The transplant program, in collaboration with New England At the Miriam Hospital, the catheterization laboratory Medical Center, is the largest in New England, with a 5 continues to be extremely busy providing both diag- year survival rate exceeding 90%! Clinical research in nostic and therapeutic interventions with a variety of heart failure currently involves studies of a parenteral coronary and noncoronary diseases. adenosine antagonist, as well as an oral vasopressin The cardiac catheterization laboratory at Rhode antagonist for patients with advanced heart failure. Island Hospital has now developed an interventional Noninvasive assessment of the contribution of myocar- service for patients with peripheral vascular disease. dial viability in patients with heart failure using nuclear This service is fully integrated with the vascular cardiac markers is studied in collaboration with Dr. surgery service, providing a full range of percutaneous Arrighi. The team has recently published an analysis of as well as surgical interventions for patients with the efficacy of outpatient management of heart failure peripheral vascular disease. A similar program is in our system. under development at the Miriam Hospital, incorpo- Research activity in the cardiology division is growing rating new dedicated faculty skilled in peripheral significantly. Dr. Gideon Koren has joined the Division, vascular disease interventions. coming from Brigham and Women’s Hospital, Boston, Over the past two years, a new rehabilitation facility has MA. Dr. Koren will direct the Cardiovascular Research opened in conjunction with the Miriam Hospital. This Center, which will occupy 10,000 sq. ft. in the Coro state of the art facility provides a full range of cardiac building. Dr. Koren is recognized internationally for his and pulmonary rehabilitation services in addition to studies of mechanisms of sudden cardiac death relating consultation for coronary risk factor reduction. to abnormalities of cardiac repolarization. He brings two The nuclear cardiology laboratory at Rhode Island NIH grants to Brown. Dr. Koren studies genetically- Hospital is now under the direction of Dr. James Arrighi. modified mice to evaluate abnormalities of potassium The laboratory performs over 3000 SPECT studies per channel function, as they relate to the long QT 6 brown medical school department of medicine

syndrome. A second series of experiments utilizes a FACULTY MEMBERS unique genetically-modified rabbit model with a lethal variant of the long QT syndrome. He is currently study- FULL-TIME FACULTY (Hospital or Foundation Based) ing the assembly and regulation of cardiac potassium Brian G. Abbott, M.D. Clinical Assistant Professor, channels, as well as mechanisms that underlie adrener- Rhode Island Hospital gically-mediated arrhythmias in long QT syndrome. J. Dawn Abbott, M.D., Assistant Professor, Joining Dr. Koren is a colleague from Brigham and Rhode Island Hospital Women’s Hospital, Dr. Ulrike Mende. Dr. Mende’s research has focused on the role of heterotrimeric G James Arrighi, M.D., Associate Professor, proteins for cardiac function, and understanding Rhode Island Hospital how derangement in G protein-mediated signal Eric Berger, M.D., Clinical Assistant Professor, transduction contributes to the development of Rhode Island Hospital cardiomyopathies. She has developed and studied Douglas Burtt, M.D., Clinical Assistant Professor, genetically modified mouse models with G protein Miriam Hospital mutations targeted to the heart to study the effect of Alfred E. Buxton, M.D., Professor, G protein derangement in vivo. She currently holds Rhode Island and Miriam Hospitals an NIH RO1 grant to study the muscarinic signaling mechanisms regulating ventricular function in detail. Gaurav Choudhary, MD, Assistant Professor, A second major focus of her research has been on VA Medical Center so-called RGS proteins, (Regulators of G protein Fredric Christian, M.D., Clinical Assistant Professor, Signaling). She was awarded a Scientist Development Rhode Island Hospital grant by the American Heart Association to study the Thomas Crain, M.D., Clinical Instructor, role of these proteins in cardiac signaling. Miriam Hospital In 2004 Dr. J. Dawn Abbott joined the Division from Thomas Drew, M.D., Clinical Associate Professor, Yale University. Dr. Abbott’s current area of funded Rhode Island Hospital investigation includes determining prognostic angio- Kristin Ellison, M.D., Assistant Professor, graphic findings in patients with acute coronary Rhode Island and Miriam Hospitals syndromes undergoing percutaneous coronary Michael Gilson, M.D., Clinical Assistant Professor, intervention. She is also evaluating novel drug eluting Rhode Island Hospital stents and devices to treat chronic coronary total occlusions in porcine models. Paul Gordon, M.D., Clinical Assistant Professor, Miriam Hospital Investigators at the Providence Veterans Administration Gary Katzman, M.D., Clinical Assistant Professor Medical Center have been very active. Dr. Gaurav Miriam Hospital Choudary studies endothelial function. He is investi- gating the role of C-type natriuretic peptide (CNP) in Edward Keating, M.D., Clinical Assistant Professor, endothelial cells exposed to hypoxia in vitro as a novel Rhode Island Hospital marker of endothelial function, as well as CNP in Malcolm Kirk, M.D., Assistant Professor, patients with sleep apnea syndrome. He also studies Rhode Island and Miriam Hospitals the use of bioimpedance based techniques to assess Charles Koo, M.D., Assistant Professor, endothelial function and vascular distensibility. Rhode Island and Miriam Hospitals Dr. Wen-Chih (Hank) Wu holds two VA-funded grants. Gideon Koren, M.D., Professor, Under the VA Target Research Enhancement Program Rhode Island Hospital grant he is studying behavioral and pharmacological Kenneth Korr, M.D., Associate Professor, intervention for cardiovascular risk reduction in diabetic Miriam Hospital patients. Under a VA Merit Review Award he is Daniel Levine, M.D., Clinical Assistant Professor, evaluating the relation between surgical blood Rhode Island Hospital transfusion practices and cardiovascular outcomes. George McKendall, M.D., Associate Professor, Rhode Island Hospital

7 cardiology

Albert S. Most, M.D., Professor, Suhdong Hahn, M.D., Clinical Assistant Professor, Rhode Island Hospital Memorial Hospital Alfred Parisi, M.D., Professor Emeritus, Andrew Hordes, M.D., Clinical Associate Professor, Miriam Hospital Memorial Hospital Athena Poppas, M.D., Assistant Professor, Jack Klie, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital Roger Raymond, M.D., Clinical Assistant Professor, Kenneth LaBresh, M.D., Clinical Associate Professor, Rhode Island Hospital Roger Williams Medical Center Raymon Riley, M.D., Clinical Professor Emeritus, Jon Lambrecht, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital James Robertson, M.D., Clinical Assistant Professor, William Levin, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital Barry Sharaf, M.D., Associate Professor, Christopher Luttmann, M.D., Clinical Assistant , Rhode Island Hospital Professor, Miriam Hospital Satish Sharma, M.D., Associate Professor, Shafiq Mamdani, M.D., Clinical Instructor, VA Medical Center Memorial Hospital Philip Stockwell, M.D., Clinical Assistant Professor, Richard Mead, M.D., Clinical Associate Professor, Rhode Island Hospital Emeritus, Rhode Island Hospital Peter Tilkemeier, M.D., Associate Professor, Robert Meringolo, M.D., Clinical Assistant, Miriam Hospital Professor, Miriam Hospital Marilyn Weigner, M.D., Clinical Assistant Professor, John F. Murphy, M.D., Clinical Assistant Professor, Rhode Island Hospital Rhode Island Hospital David Williams, M.D., Professor, Thomas Noonan, M.D., Clinical Assistant Professor, Rhode Island Hospital Memorial Hospital Wen-Chih Wu, M.D., Assistant Professor, Arthur Phillips, M.D., Clinical Assistant Professor, VA Medical Center Emeritus, Memorial Hospital Susan Potter, M.D., Clinical Teaching Associate, VOLUNTEER FACULTY Memorial Hospital Anthony Cannistra, M.D., Clinical Assistant Professor, Barbara Roberts, M.D., Clinical Associate Professor, Memorial Hospital Miriam Hospital Lauralyn Cannistra, M.D., Clinical Assistant, Ara Sadaniantz, M.D., Clinical Assistant Professor, Professor, Memorial Hospital Miriam Hospital Frank Capizzo, M.D., Clinical Assistant Professor, Gisele Saliba, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital Robert Carnevale, M.D., Clinical Assistant Professor, Jay Schachne, M.D., Clinical Instructor, Rhode Island Hospital Rhode Island Hospital Jonathan Elion, M.D., Associate Professor, Franklin Schneider, M.D., Clinical Instructor, Miriam Hospital Miriam Hospital Steven Fera, M.D., Clinical Assistant Professor, Robert Schwengel, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital David Fortunato, M.D., Clinical Assistant Professo, Richard Shulman, M.D., Clinical Associate Professor, VA Medical Center Miriam Hospital Joseph Gaeta, M.D., Clinical Assistant Professor, Mitchel Sklar, M.D., FACC, Clinical Instructor, Emeritus, Rhode Island Hospital Miriam Hospital Peter Gibson, M.D., Clinical Instructor, Joseph Spinale, D.O., Clinical Instructor, Memorial Hospital Miriam Hospital Ned Gutman, M.D., Clinical Assistant Professor, 8 Miriam Hospital brown medical school department of medicine

Joseph Terlato, M.D., Clinical Assistant Professor, Invited Presentations: Rhode Island Hospital I International Conference of Nuclear Cardiology - Edward Thomas, M.D., Clinical Assistant Professor, “Pitfalls of quantification of perfusion.” Lisbon, Rhode Island Hospital Portugal I International Conference of Nuclear Cardiology - ADJUNCT FACULTY “Semiquantitative versus quantitative perfusion.” David DeNofrio, M.D., Adjunct Assistant Professor, Lisbon, Portugal Rhode Island Hospital I Society of Nuclear Medicine Annual Meeting (Mid- Lynne Johnson, M.D., Adjunct Professor, Eastern Chapter) - “Nuclear cardiology basics: Rhode Island Hospital isotopes, stressors, and protocols.” Ocean City, MD Harry Schwartz, M.D., Clinical Assistant Professor, I ACC Annual Scientific Sessions (Moderator and Miriam Hospital Presenter) - “Read with the experts: myocardial viability imaging.” Orlando NATIONAL AND INTERNATIONAL I ASNC Annual Scientific Session - “Overview of HONORS AND RECOGNITION PET: Tracers, techniques, and protocols.” New York OF FACULTY I ASNC Nuclear Cardiology for the Technologist Meeting - “Gated SPECT imaging.” Baltimore Brian G. Abbott, M.D. I ASNC Nuclear Cardiology for the Technologist Invited Lectures: Meeting, - “Using quantitation.” Baltimore I International Congress of Nuclear Cardiology 7 - I ASNC Affiliated Combined Working Groups “Special topics in Nonischaemic Cardiomyopathy: Meeting (Moderator) - “Update in pharmacologic Differentiation form Ischemic cardiomyopathy,” stress.” Mystic, CT Lisbon, Portugal I ASNC Affiliated Combined Working Groups I International Congress of Nuclear Cardiology 7 - Meeting - “Radionuclide imaging in acute coronary “Chest Pain evaluation in the Emergency syndromes.” Mystic, CT Department: clinical data, Biomarkers and ECG,” I American Society of Nuclear Cardiology Annual Lisbon, Portugal Meeting - “Overview of PET: Tracers, techniques, I Nuclear Cardiology for the Technologist - “CAD and protocols.” Indianapolis Pathophysiology,” Baltimore, MD I Nuclear Cardiology Symposium - “New tracers and I American Society of Nuclear Cardiology Annual techniques in nuclear cardiology.” University of Meeting and Scientific Session - “’Hot Spot” Maryland Medical Center Baltimore Imaging: Issues and Implications,” , New York, NY Alfred E. Buxton, M.D. I American Society of Nuclear Cardiology Annual Editorial Boards: Meeting and Scientific Session - “Optimizing I Associate Editor - The American Journal of Cardiology Myocardial Perfusion Imaging Protocols”,New York, NY I Editorial Board - Journal of Cardiovascular Electrophysiology I American Society of Nuclear Cardiology Annual Meeting and Scientific Session - “Arrhythmia I Editorial Board – Journal of the American College Recognition,” New York, NY of Cardiology I I American Society of Nuclear Cardiology Annual Editorial Board – Journal of the Heart Rhythm Meeting and Scientific Session - Moderator: Society Moderated Poster session, New York, NY Invited Presentations: I Temple University School of Medicine, Medical Grand J. Dawn Abbott, M.D. Rounds – “Prevention of Sudden death in Patients Reviewer: with Ischemic Heart Disease,” Philadelphia, PA I Circulation I Northwestern University School of Medicine, James A. Arrighi, M.D. Cardiology Research Conference - “Prevention of Editorial Boards: Sudden death in Patients with Ischemic Heart I Journal of Nuclear Cardiology Disease,” Chicago, IL 9 cardiology

I Cornell Medical School – Update on Cardiac Performed in All Coronary Disease Patients with Arrhythmias – “Primary Prevention of Sudden EF 30-40% - Protagonist,” New Orleans, LA Death,”New York, NY Thomas M. Drew, M.D. I North American Society of Pacing and Guest Editor: Electrophysiology, 24th Annual Meeting – I Catheterization & Cardiovascular Interventions Controversies Electrophysiology – “Risk stratifica- tion in coronary disease: All you need is EF – Invited Presentations: I Antagonist,” Washington, DC SAARC Cardiovascular Conference - Carotid Stenting. Kathmandu, Nepal. I American Heart Association 76th Annual Scientific Sessions – Cardiovascular Seminar – Electrophysiology Paul C. Gordon, M.D. of Sudden Cardiac Death, “Prevention of Sudden I Speaker, Intervention 2004, Boston Cardiac Death – Role of Devices,”Orlando, FL Gideon Koren, M.D. I Beth Israel/Deaconess Medical Center, Cardiology I Gordon Research Conference, Program Committee Grand Rounds – “Mechanisms and Prevention of Sudden Death in Patients with Coronary Artery Kenneth S. Korr, M.D. Disease,” Boston, MA Invited Presentations: I American College of Cardiology, Annual Scientific I Dominican Society of Cardiology, CEDIMAT, Session – Chair, Panel, “New Implantable Cardioverter Santo Domingo, Dominican Republic- Defibrillator Indications ,”New Orleans, LA I “Evolving Strategies in the Treatment of Acute MI” I Tulane University School of Medicine, Medicine I “Evaluation of the Cardiac Patient for Non-Cardiac Grand Rounds, “Prevention of Sudden Death – Surgery” How Should Recent Trials Affect management?” New Orleans, LA Daniel J. Levine, MD I Heart Rhythm Society Annual Meeting. Featured Invited Presentations: Debate – “Risk Stratification for VT by Noninvasive I Device Therapy for Treatment of Advanced Heart Methods is Possible – Antagonist,” San Francisco, Failure 2004 Conference, Tufts University School of CA Medicine

I University of Pennsylvania School of Medicine. Albert S. Most, M.D. Leonard Horowitz Memorial Lecture. “Does Honors and Awards: Everyone with Heart Disease Need an ICD? Can We I The Milton Hamolsky Lifetime Achievement Award Identify the Low risk Patient? Philadelphia, PA – 2003 (Awarded by the RI chapter of the American I Vanderbilt University. Cardiology Grand Rounds. College of Physicians) “Prevention of Sudden Death – Who Benefits from I The John H. Chafee Award Commemorating the ICD?” Nashville, TN Leadership in Healthcare - 2005 (Awarded by the I American Heart Association Annual Scientific RI chapter of the American Heart Association) Sessions – “Controversies in Clinical Cardiology: Everyone with an Ejection Fraction of <0.40 Alfred Parisi, M.D. Should Receive an ICD: Con,” New Orleans, LA Invited Presentations: I David Littmann Lecture, West Roxbury VA Medical I Brigham and Women’s Hospital. Cardiology Grand Center, Harvard Medical School - “From Infection Rounds - “Does Everyone with Heart Disease Need to Inflammation—Progress in Cardiovascular an ICD?” Boston, MA Disease over Half a Century” I American College of Cardiology, Annual Scientific I Robinson Lecture, University of Massachusetts- Session 2005– Great Debates in Electrophysiology: Memorial Medical Center - “From Infection to Patients With Idiopathic Dilated Cardiomyopathy Inflammation-Progress in Cardiovascular Disease Should Now Undergo Implanted Cardioverter over Half a Century” Defibrillator Implantation When the Ejection Fraction Is Less 35%— Antagonist, Orlando, FL I Annual Meeting of American Society of Echocardiography - “Prosthetic Heart Valves—the I Heart Rhythm Society Annual Meeting, Featured Case for Thrombolysis” Debate “Electrophysiologic Testing Should be 10 brown medical school department of medicine

Athena Poppas, M.D. Ischemia Syndrome Evaluation (WISE) Study. Invited Presentations: Latest Developments in QCA, QCU, QVA; I American College of Cardiology Scientific Sessions Applications in Clinical Trials (MEDIS) (SCAI : Spotlight Session - Hypertrophic Cardiomyopathy Meeting). Boston, Massachusetts. and Echocardiography. Chicago, IL I Qualitative and Quantitative Results from Optical I Twentieth Annual International Conference on Coherence Tomography in Humans and Animals. Advances in Echocardiography: Read with the Experts Current Trends in Coronary Stenting. Falmouth, - Echocardiography Case Studies: New Orleans, LA Massachusetts. I American College of Cardiology Scientific Sessions: I Diagnosis and Therapy of Ischemic Heart Disease Spotlight Session - Interventional Echocardiography. in Women. The Evaluation of Treatment Options New Orleans, LA for Margin High Risk Patients, New York, N.Y. I American Heart Association, Scientific Sessions, I Angiographic Core Laboratory. VISION Cardiovascular Seminars - Hemodynamics and Investigator Meeting. Miami Beach, Florida Echocardiography in Normal Pregnancy. New I American Heart Association Abstract Orleans, LA Chairman/Moderator - Scientific Sessions Stents: I American College of Cardiology Scientific Sessions, Outcome Results. New Orleans, LA Echo Spotlight Session - Abnormalities of Systolic Function: Why is this patient in heart failure? Peter L. Tilkemeier, M.D. Orlando, FL Invited Presentations in National Meetings: I 26th Annual High Country Nuclear Medicine I Society of Cardiovascular Angiography and Conference - “DICOM and Connectivity.”Vail, CO Intervention Breakfast Symposium - Genesis of I Stroke in Atrial Fibrillation. Boston MA American College of Cardiology, Annual Meeting - “IHE and Cardiology: An Introduction.” Orlando, FL I American Society of Echocardiography - Echocardiography in Interventional Procedures. Las David O. Williams, M.D. Vegas, NV Editorial Review Boards: I American Society of Echocardiography - I CC Cardiosource Clinical Trials Echocardiography in Elderly Women. Las Vegas, NV I The American Heart Hospital Journal I Preventative Cardiovascular Nurse Practitioners Editorial Consultant: Association. Plenary Session - Stress Testing in I Journal of the American College of Cardiology Women. New Orleans, LA I American Society of Echocardiography - Wen-Chih Wu, M.D. Hemodynamics and Echocardiography in Normal Invited Presentations in National Meetings: Pregnancy. Boston, MA I Society of Critical Care Medicine 33rd Critical Care Congress - Blood Transfusion Use in AMI : I American Society of Echocardiography - High Risk Cardiac Lesions in Pregnancy. Boston, MA Transfusion Medicine Today – Blood Banking,” Orlando, Florida. I Chapter of the ACC Course Co-Director - Heart Disease in Women, Cardiology for the Primary Care Provider. Providence, RI RESEARCH AND OTHER I American Society of Echocardiography SCHOLARLY ACTIVITIES Sonographer Review Course - Stress Echocardiography. Worchester, MA FACULTY MEMBERS OF STUDY SECTIONS AND ADVISORY COMMITTEES Barry L. Sharaf, M.D. Editorial Review Boards: Brian Abbott, M.D. I Journal of the American College of Cardiology I American Society of Nuclear Cardiology, Board of I Coronary Artery Disease Directors I I American Journal of Managed Care Nuclear Cardiology for the Technologist, Program Co-chair Invited Presentations: I Findings from the NHLBI - Sponsored Women’s 11 cardiology

James Arrighi, M.D. I NIH RO1, Heart and muscles K+ channels: I Certification Board of Nuclear Cardiology, Board of Assembly and regulation, Principal Investigator Directors (Secretary) I NIH RO1, Trafficking and subcellular distribution of I American College of Cardiology, Member, Planning cardiac potassium channels, Principal Investigator Committee, Cardiac Imaging Spotlight Session Alfred Parisi, M.D. I American Society of Nuclear Cardiology Scientific Session Chair: Sessions Programming Committee, Chairman I Annual Meeting of American College of Cardiology Cardiology—Acute Aortic Diseases – 2004 I Certification Board of Nuclear Cardiology, Chairman, I Annual Meeting of American Society of Question Writing and Reviewing Task Force Echocardiography—Echocardiographic Assessment I Certification Board of Nuclear Cardiology, of Cardiac Risk Factors - 2005 Chairman, Electronic Examination Task Force Athena Poppas, M.D. I American Society of Nuclear Cardiology, Member, I Research Grants Committee American Society of Echocardiography, Women’s Health Advisory Group I American Society of Nuclear Cardiology, Member, I Newsletter Committee American Society of Echocardiography, Membership Steering Committee I American Heart Association Annual Scientific I Sessions, Member, Abstract Selection Committee American College of Cardiology, Allied Health Professionals Committee I International Conference of Nuclear Cardiology, I Member, Abstract Selection Committee American College of Cardiology, Women in Cardiology Committee Alfred E. Buxton, M.D. I ACC/AHA/NASPE Electrophysiology Data I ACC/AHA/ESC Ventricular Arrhythmias and Standards Writing Committee Sudden Cardiac Death ACC/AHA/ESC guidelines I American College of Cardiology Board of Trustees writing committee Working Group: Review Environmental I ACC/AHA/HRS Committee on Electrophysiology I Trend Information to Assist with Strategic Planning Data Standards, Chairman I American College of Cardiology, Task Force to I ACC/HRS National ICD Registry, Chairman Develop Ethics Agenda I American Board of Internal Medicine, Recent I American College of Cardiology, Women in Advances in Cardiology, Self Evaluation Process Cardiology Committee, Chair Committee I American Heart Association, Women in Cardiology I American Board of Internal Medicine, Self Committee Evaluation Process Committee for Cardiology I American College of Cardiology Section Women in I Medicare Coverage Advisory Committee on ICD Cardiology, Professional Life Survey Work Group, Utilization (MADIT II Review), Member, Chair Baltimore, MD I American College of Cardiology, Nominating Thomas Drew, M.D. Committee Program Committees: I American College of Cardiology, Governor, Rhode I Physicians For Peace, Site Visit Kathmandu, Nepal, Island Chapter Team Member. I Peter L. Tilkemeier, M.D. I Skills for the New World of Health Care, Faculty I Intersocietal Commission for the Accreditation of Member, Kennedy School of Government, Harvard Nuclear Medicine Laboratories University, Cambridge MA I American Society of Nuclear Cardiology and I Third Annual Cardiology for the Primary Care Society of Nuclear Medicine, Co-chair, DICOM Provider, Faculty Member, Warwick, RI Committee I Second Annual Symposium on Men’s Health Care, I American Society of Nuclear Cardiology, Quality Faculty member, “The Aging Male”,Providence, RI Assurance Committee 12 brown medical school department of medicine

I American College of Cardiology, IHE Cardiology TEACHING RESPONSIBILITIES Planning Committee James Arrighi, M.D. I Lifespan Academic Medical Center, Co- chairman I Program Director, Fellowship in Cardiovascular Continuing Medical Education Committee Disease, Brown Medical School David O. Williams, M.D. Douglas Burtt, MD I National Heart, Lung and Blood Institute Committees I Director, Brown Medical School 2nd year :Cardiac I Data, Safety and Monitoring Committee, TRITON Pathophysiology and Pharmacology – TIMI 38, Chairman Alfred Buxton, M.D. I Data, Safety and Monitoring Committee, ZoMaxx I I&II Clinical Trial, Chairman Program Director, Clinical Cardiac Electrophysiology Fellowship National Committees: I Lecturer, Brown Medical School 2nd year :Cardiac I American College of Cardiology Pathophysiology and Pharmacology I Cardiac Catheterization and Intervention Committee, Chair Daniel Levine, MD I ACCEL Editorial Board, Associate Editor I Instructor, Brown Medical School 2nd year :Cardiac Pathophysiology and Pharmacology I Task Force to Develop Interventional Cardiology Business Plan Paul Gordon, M.D. I American Heart Association I Director, Cardiac Catheterization Laboratory I Fellow, Council on Cardiovascular Radiology (2003), Director Interventional Cardiology Training Program, The Miriam Hospital I Interventional Cardiology Subcommittee, Maryland Health Care Commission, Chairman I Lecturer, Brown Medical School 2nd year :Cardiac Pathophysiology and Pharmacology I Brown Medical School I Chairman, Search Committee, Director of Kenneth Korr, M.D. Cardiology, Memorial Hospital of Rhode Island I Lecturer, Brown Medical School 2nd year :Cardiac Pathophysiology and Pharmacology

TEACHING ACTIVITIES George McKendall, M.D. I Lecturer, Brown Medical School 2nd year :Cardiac EDUCATION HONORS Pathophysiology and Pharmacology

Alfred Buxton, MD Alfred Parisi, M.D. I Dean’s Teaching Excellence Award I Medical House Staff Report, The Miriam Hospital

Thomas Drew, MD Athena Poppas, M.D. I Teaching Recognition Citation, Brown Medical School I Director, Cardiology Fellowship Echocardiography Curriculum Paul Gordon, MD I I Dean’s Teaching Excellence Award Mentor, Office of Women in Medicine, Brown Medical School Daniel Levine, MD I Excellence in Teaching Award Philip Stockwell, M.D. I Course Director, Biomed 310 — Consultative Marilyn Weigner, MD Cardiology. I Teaching Recognition Award, Brown Medical I Director, Cardiology Grand Rounds and Friday School, 2004 Clinical Cardiology Conference

David O. WIlliams, M.D. I Program Director, Interventional Cardiology Fellowship, Rhode Island Hospital

13 cardiology

CARDIOLOGY FELLOWSHIP PROGRAM Current Fellows

Name Medical School Residency Wing Kin Fung, MD Tufts University School of Medicine Tufts-NEMC David Glassman, MD Indiana University University of Iowa Craig McMackin, MD Termple Univ. Medical School Boston Medical Center Brad Mikaelian, MD Loyola University Boston Medical Center Richard Regnante, MD MCP-Hahnemann School of Medicine Rhode Island & Miriam Hospital Aaron Weisbord, MD University of California Los Angeles Beth Israel/Deaconess Michael Castine, MD UMDNH-New Jersey Medical School Tufts-NEMC Russell Linsky, MD Univ. of Arkansas for Medical Sciences Univ. of Arkansas for Medical Sciences David Major, MD Wake Forest Univ. School of Medicine Wake Forest Univ. Baptist Medical Center Nathan Ritter, MD Univ. of Alabama, Birmingham Univ. of Miami, Jackson Memorial Hosp Steven Weinsier, MD Univ. of Alabama, Birmingham Univ. of Maryland Medical Center Ohad Ziv, MD Univ. of Pittsburgh School of Medicine Columbia Presbyterian Hospital Maryam Afshar, MD Flinders Univ. of South Australia (Australia) Yale Univ. School of Medicine Youngsoo Cho, MD Albert Einstein College of Medicine Rhode Island & Miriam Hospitals Shalin B. Mehta, MD University of Maryland Case Western Reserve Univ. Adam Niedelman, MD Jefferson Medical College Rhode Island & Miriam Hospitals Clifford Sebastian, MD Albany Medical College Temple University Hospital Victor H. Shin, MD New York Univ. School of Medicine Thomas Jefferson Univ. Hospital

Electrophysiology Name Medical School Residency Fausto G. Devecchi, MD University of Turin, Italy Roger Williams Medical Center Jamie H. Kim, MD Tufts University NEMC Peem Lorvidhaya, MD Chiang Mai University, Thailand John A Burns School of Medicine, Hawaii Kai-Chun Sung, MD Columbia Univ. of P&S Baylor College of Medicine Interventional Rhode Island Hospital Name Medical School Residency Edward J. Choi, MD Wake Forest Univ. School of Medicine UMDNJ-Robert Wood Johnson Matthew Voss, MD Southern Illinois Univ. School of Med Yale-New Haven Hospital The Miriam Hospital Name Medical School Residency Pranav Patel, MD St. Louis Univ. School of Medicine Case Western Reserve Univ. John Waggoner, MD Oregon Health Sciences University University of Vermont, Fletcher Allen

14 brown medical school department of medicine

DEPARTING FELLOWS

Rhode Island Hospital 2004, General Cardiology Name Medical School Residency Post Graduate Plans Maria T. Anderson, MD Tufts Univ. SOM Travis Air Force Base EP Fellowship RIH George G. Scleparis, MD Tufts Univ. SOM Univ. of Massachusetts Med. Ctr. Private Practice in Nevada Linda G. Yan, MD Univ. of Buffalo SOM Univ. Hospital at Stony Brook Private Practice in Georgia Interventional 2004 Name Medical School Residency Post Graduate Plans Mark Napoli, MD Louisiana State Univ. Wake Forest Univ. Baptist Private Practice in Med. Ctr. Louisiana, Orleans SOM Michael Gen, MD St. Georges Albany Medical Center & Private Practice in California Univ. SOM Univ. of Colorado The Miriam Hospital 2004 Name Medical School Residency Post Graduate Plans George Aziz, MD Med College of Ohio Loyola University Med. Ctr. Interventional Cardiology Miriam Janak H. Bhavsar, MD UMDNJ–NJ Med School Mayo Clinic Interventional Cardiology Miriam Linda A. Ireland, MD Philadelphia College of Lehigh Valley Hospital Private Practice in Alaska Osteopathic Medicine Andrew Nowak, MD Univ. of Mass Med. School Univ. of Mass Med Center Private Practice in Rhode Island Interventional 2004 Name Medical School Residency Post Graduate Plans David Bailey, MD Univ. College, London Yale University Private Practice in Florida Medical School John Golding, MD Meharry Med SOM Washington Hospital Center Private Practice in Coll Tennessee Combined Program of the Rhode Island & Miriam Hospitals General Cardiology Name Medical School Residency Post Graduate Plans Edward J. Choi, MD Wake Forest Univ. SOM UMDNJ-Robert Wood Johnson Interventional Cardiology-RIH Mark C. Heckel, MD Temple Univ. SOM RIH & Miriam Hospitals Private Practice in N. Carolina Jamie H. Kim, MD Tufts University SOM New England Medical Center EP Fellowship at RIH Daniel Guralnick, MD Univ. of Alabama Virginia Mason Medical Center Private Practice in Washington Pranav Patel, MD St. Louis Univ. SOM Case Western Reserve Univ. Interventional Cardiology TMH Kai-Chun Sung, MD Columbia Univ. of P&S Baylor College of Medicine EP Fellowship at RIH John Waggoner, MD Oregon Health Sciences University of Vermont Interventional Cardiology-TMH Electrophysiology Name Medical School Residency Post Graduate Plans Maria T. Anderson, MD Tufts University SOM Travis Air Force Base Private Practice in Colorado Gaurang Gandhi, MD University of Baroda Coney Island Hospital Private Practice in Ohio Sameh Khouzam, MD Ain Shams University Cleveland Clinic Private Practice in Ohio Arun Kolli, MD Osmania Medical College SUNY Upstate Medical Ctr. Private Practice in Nevada Rhode Island Hospital Interventional Name Medical School Residency Post Graduate Plans Jeffrey Trost, MD U Pennsylvania SOM Parkland Hospital Private Practice in Maryland The Miriam Hospital Interventional Name Medical School Residency Post Graduate Plans George Aziz, MD Medical College of Ohio Loyola University Med. Center Private Practice in Illinois Janak H. Bhavsar, MD UMDNJ–NJ Med School Mayo Clinic Private Practice in New Jersey 15 cardiology

SELECTED PUBLICATIONS I Arrighi JA, Burg M, Cohen IS, Soufer R. Simultaneous assessment of myocardial perfusion Brian G. Abbott, M.D. and function during mental stress in patients with I Vashist A, Abbott BG. Cardiac Imaging in the chronic coronary artery disease. J Nucl Cardiol Evaluation of Suspected Acute Coronary 2003;10:267-74. Syndromes, Expert Review of cardiovascular Alfred E. Buxton, M.D. Therapy 3(3):473-86, 2005 May. I Russo AM, Hafley GE, Lee KL, Stamato NJ, Lehmann I Abbott, BG, Arrighi JA. Potential Value of MH, Page RL, Kus T, Buxton AE. Racial Differences Screening stress Myocardial Perfusion Imaging in in Outcome in the Multicenter UnSustained Asymptomatic Diabetics without Known Tachycardia Trial (MUSTT): A Comparison of Coronary Disease. Journal of Nuclear Cardiology Whites Versus Blacks. Circulation 2003;108:67-72. 10(1):S43, 2003 Jan. I Zimetbaum PJ, Buxton AE, Batsford W, Fisher JD, J. Dawn Abbott, M.D. Hafley GE, Lee KL, O’Toole MF, Page RL, I Abbott, J.D, MD, Choi, E.J., MD, Selzer, F., PhD, Reynolds M, Josephson ME. Electrocardiographic Srinivas, V.S., MD, and Williams, D.O., MD. Coronary predictors of arrhythmic death and total mortality Collateral Status Impacts Outcome After Percutaneous in the Multicenter Unsustained Tachycardia Trial. Coronary Intervention: An Analysis From the NHLBI Circulation 2004;110:766-769. Dynamic Registry (in press AJC sept 2005) I Russo AM, Stamato NJ, Lehmann MH, Hafley GE, I Abbott, J.D., MD, Huang, Y., PhD, Liu, D.,MD, Hickey, Lee KL, Pieper K, Buxton AE and the MUSTT R., Krause, D.S., MD, PhD, and Giordano, F.G.,MD. Investigators. Influence of gender on arrhythmia SDF-1 Plays a Critical Role in Stem Cell Recruitment characteristics and outcome in the Multicenter to the Heart After Myocardial Infarction but is not Unsustained Tachycardia Trial. J Cardiovasc Sufficient to Induce Homing in the Absence of Injury, Electrophysiol 2004;15:993-998. Circulation, 110: 3300 – 3305, 2004. I Buxton AE, Sweeney MO, Wathen MS, Josephson I Abbott, J.D., MD, Curtis, J.P., MD, Murad, K, MD, ME, Otterness MF, Hogan-Miller E, Stark AJ, et al. Spontaneous Coronary Dissection in a DeGroot PJ, for the PainFREE RXII Investigators. Women Receiving 5-Fluorouracil, Angiology, QRS Duration Does Not Predict Occurrence of 54(6): 721-24, 2003. Ventricular Tachyarrhythmias in Patients with Implanted Cardioverter-Defibrillators. J Amer Coll I Abbott, J.D., MD, Brennan, J.J., MD, and Remetz, Card. 2005;46:310-316. M.S., MD, Treatment of a Left Internal Mammary Artery to Pulmonary Artery Fistula with I Buxton AE. Sudden death after myocardial infarction Polytetrafluoroethylene Covered Stents, – who needs prophylaxis and when? N Engl J Med. CardioVascular and Interventional Radiology, Jan- 352:2638-2640, 2005 Feb; 27(1):74-6, 2004. Malcolm M. Kirk, M.D. I Abbott, J.D., MD and Giordano, F.J., MD, Stem I Kirk, M.M., Izu, L.T., Chen-Izu, Y., McCulle, S.L., Cells and Cardiovascular Disease, J Nucl Cardiol Wier, W.G. Balke, C.W., Shorofsky, S.R. Role of the 2003; 10(4):403-12. Transverse-Axial Tubule System in Generating Calcium Sparks and Calcium Transients in Rat James A. Arrighi, M.D. Atrial Myocytes. J. Physiol. 2003; 547.2, 441-451. I Vashist A, Arrighi JA, Soufer R. Mechanistic and methodologic considerations for the imaging of men- I Khouzam, S., Kirk, M. Chonic Pharmacological tal stress ischemia. In: Zaret BL, Beller GA. Clinical Therapy for Atrial Fibrillation and Flutter Medicine Nuclear Cardiology. Philadelphia:Elsevier; 2005. & Health, Rhode Island. 2004 87(4):104-107 I I Abbott BG, Arrighi JA. Screening stress myocardial Anderson, M, Kirk, M. Anticoagulation in Atrial perfusion imaging for risk stratification in asymp- Fibrillation. Medicine & Health, Rhode Island. tomatic diabetic men. J Am Coll Cardiol 2004 2004 87(4):98-100 I I Abbott BG, Liu Y, Arrighi JA. F-18-fluo- Kirk, M. Basics of Pacing, in Guide to Pacing and rodeoxyglucose as a memory marker of transient Device Therapy for Cardiac Disorders, Buxton, myocardial ischemia. J Am Coll Cardiol 2004 A.E., and Chow, A., Eds. In press 16 brown medical school department of medicine

I Frain, B H., Ellison, K. E., Michaud, G. F., Gibbs M. I Jefferson A., Poppas A., Paul R., Cohen R. Cardiac E., Koo C. H., Gandhi G. D., Khouzam S., Buxton A. output and cognition: A relationship between E., Kirk, M. M. True Bipolar Defibrillator Leads Have systemic hypoperfusion and executive dysfunction Increased Threshold and Sensing Latency Compared Neurobiology of Agings. (in press) 2005 to Integrated Bipolar Configuration. Pacing and Cardiac Electrophysiology 2003, 26(4), part II, A331 Barry Sharaf, M.D. I Bairey Merz CN, Johnson BD, Sharaf BL, Bittner B, Kenneth S. Korr, M.D. Berga SL, Braunstein GD, Hodgson TK, Matthews I Korr KS, Sadaniantz A: Neurologic Event, Mitral KA, Pepine CJ, Reis SE, Reichek N, Rogers WJ, Valve Mass and Fibroelastoma in a Young Patient: Pohost GM, Kelsey SF, Sopko G. Hypoestrogenemia Cardiovascular Reviews & Reports Vol. 14:583-584, of Hypothalamic Origin and Coronary Artery 2003 Disease in Premenopausal Women: A Report from the NHBLI-Sponsored (WISE) Study. Journal of the Alfred Parisi, M.D. American College of Cardiology 2003;41:413-9. I Marcus BH, Lewis BA, King TK, Albrecht AE, I Doyle M, Fuisz A, Kortright E, Biederman RW, Hogan J, Bock B, Parisi AF, Abrams, DB Rationale, Walsh EG, Martin ET, Tauxe L, Rogers WJ, Bairey design and baseline data for Commit to Quit II: An Merz CN, Pepine CJ, Sharaf BL, Pohost GM. Evaluation of the efficacy of moderate-intensity The Impact of Myocardial Flow Reserve on the physical activity as an aid to smoking cessation in Detection of Coronary Artery Disease by Perfusion women. Preventive Medicine 36:479-492, 2003 Imaging Methods: An NHLBI(WISE) Study. I Grayston JT, Kronmal RA, Jackson LA, Parisi AF, Journal of Cardiovascular Magnetic Resonance Muhlestein JB, Cohen JD, Rogers WJ, Crouse JR, 2003;5:(3)475-485. Borrowdale SL, Schron E, Knirsch C, for the ACES I Marroquin OC, Kip KE, Kelley DE, Johnson BD, Investigators: Azithromycin for the Secondary Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Prevention of Coronary Events. New Engl J Med Sopko G, Reis SE. The Metabolic Syndrome 352:1637-45, 2005 Modifies the Cardiovascular Risk Associated with Athena Poppas, M.D. Angiographic Coronary Artery Disease in Women: A I Thambar ST, Schofield L, Poppas A, Bouchard M, Report from (WISE). Circulation 2004;109:714-721. Williams DO, Johnson LL,. Validation of R wave I Arant CB, Wessel TR, Olson MB, Bairey Merz CN, Voltage Endomyocardial Mapping to Assess Sopko G, Rogers WJ, Sharaf BL, Reis SE, Smith K, Myocardial Fibrosis: Comparison with Thallium Johnson BD, Handberg E, Mankad S, Pepine CJ. and Dobutamine Echocardiography in a Swine Hemoglobin Level is an Independent Predictor for Model. J Interv Cardiol 16(1): 23-31, 2003. Adverse Cardiovascular Outcomes in Women I Poppas A, Sheehan F, Harm V, Kornowski R, Undergoing Evaluation for Chest Pain: Results from Reisman M. Myocardial Viability by the NHLBI (WISE) Study. Journal of the American Electromechanical mapping: Three-dimensional College of Cardiology 2004;43:2009-14. Validation by Dobutamine Stress I Wessel TR, Arant CB, Olson MB, Johnston BD, Echocardiography. AJC 93(9): 1097-1101, 2004 Reis SE, Sharaf BL, Shaw LJ, Handberg E, Sopko G, I Johnson L, Schofield L, Bouchard M, Chaves M, Kelsey SF, Pepine CJ, Bairey Merz CN. Relationship Poppas A, Reinert S, Zalesky R, Creech J, Williams of Physical Fitness vs Body Mass Index With DO. Hyperbaric Oxygen Solution Infused into the Coronary Artery Disease and Cardiovascular Events Anterior Interventricular Vein at Reperfusion in Women. JAMA 2004;292:1179-1187. Reduces Infarct Size in Swine. Am J Physiol Heart Peter Tilkemeier, M.D. Circ 287: H2234-H2240, 2004 I Todaro, J.F., Shen, B.J., Niaura, R., Tilkemeier, P.L., I Ostermayer SH, Reisman M, Karamer P, Matthews Roberts, B. Do men and women achieve similar R, Gray W, Block P, Omran H, Bartorelli A, Bella benefits from cardiac rehabilitation? Journal of P, DiMario C, Pappone C, Casale P, Moes JW, Cardiopulmonary Rehabilitation, 24, 45-51, 2004. Poppas A, et al. Percutaneous Left Atrial I Afshar, M., Tilkemeier, P.L. The Utility of Gated Appendage Transcatheter Occlusion (PLAATO) SPECT imaging in quantitative and regional ejection to Prevent Stroke in High Risk Patients with fraction, Chest, 127(3):701-702, 2005. Non-Rheumatic Atrial Fibrillation. Journal of the 17 American College of Cardiology: 46:9-14, 2005. cardiology

I Todaro, J.F., Shen, B.J., Niaura, R., Tilkemeier, P.L. I Holmes DR, Selzer F, Johnston JM, Kelsey SF, Prevalence of depressive disorders in men and Holubkov R, Cohen HA, Williams DO, Detre KM: women enrolled in cardiac rehabilitation, Journal of Modeling and risk prediction in the current ear of Cardiopulmonary Rehabilitation, 25(2):71-75, 2005. interventional cardiology. A report from the I Tilkemeier, P.L., Cooke, C.D., Ficaro, E.P., Glover, National Heart, Lung, and Blood Institute Dynamic D.K., Hansen, C.L., McCallister, B.D., Standardized Registry. Circulation 2003;107:1871-1876. Reporting Matrix for Radionuclide Perfusion I Williams DO: Treatment delayed is treatment Imaging, Journal of Nuclear Cardiology, In Press. denied. Circulation 2004;109:1806-1808.

David O. Williams, M.D. Wen Chi Wu, M.D. I Thambar ST, Schofield L, Poppas A, Bouchard M, I Wu WC, Ireland LA, Sadaniantz A. Evaluation of Williams DO, Johnson LL: Validation of R wave volt- aortic valve disorders using stress echocardiography. age endomyocardial mapping to assess myocardial Echocardiography 2004;21:451-8. fibrosis: Comparison with thallium and dobutamine. I Sadaniantz A, Katz A, Wu WC. Miscellaneous use Journal of Interventional Cardiology 2003;16:23-31. of stress echocardiography in patients with chron- I Cohen HA, Williams DO, Holmes DR Jr., Selzer F, ic pulmonary disease or congenital heart defect. Kip KE, Johnston JM, Holubkov R, Kelsey SF, Detre Echocardiography 2004;21:477-84. KM. Impact of age on procedural and 1-year out- I Wu WC, Aziz GF, Sadaniantz A. Evaluation of come in percutaneous transluminal coronary angio- aortic valve disorders using stress echocardiography. plasty: A report from the NHLBI Dynamic Registry. Echocardiography 2004;21:459-66. American Heart Journal 2003;146:513-519. I Wu WC, Bhavsar JH, Sadaniantz A. An overview of I Williams DO: A twist in our understanding of stress echocardiography in the study of patients enzyme elevation after coronary intervention. with dilated and hypertropic cardiomyopathy. Editorial. Journal of the American College of Cardiology Echocardiography 2004;21:467-75. 2003;42(11)1906-1908. I Wu WC, Gordon PG. Invasive management of patients with ST elevation MI with >12 hour delay in presentation, the question remains unanswered. Chest 2004;126:2-4. Listings are limited to the 5 most recent publications per faculty member.

18 brown medical school department of medicine

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $354,448 $143,463 $497,911 for Cardiology Academic Year 2004 $267,387 $66,262 $333,649

Total Clinical Research Expenses Academic Year 2003 $910,844 $95,107 $1,005,951 for Cardiology Academic Year 2004 $1,086,854 $164,579 $1,251,433

BASIC RESEARCH Alfred Buxton, M.D. I Dual Chamber and VVI Implantable Defibrillator Lynne Johnson, M.D. Trial. University of Washington/Pacesetter I Targeting MMP’s to Image Atherosclerosis. I Atrial Fibrillation and Congestive Heart Failure. University of California, Irvine/NIH Research Centre of the Montreal Heart Institute I Imaging Angiogenesis in Chronic Hibernation. I MESH 7033: Investigational Atrial Fibrillation National Heart, Lung and Blood Institute Ablation Study. CR Bard I Optical Coherence Tomography in Coronary I Fibrillation Registry Assessing Costs, Therapies, Imaging, LightLab Imaging, LLC Adverse Events and Lifestyle. AstraZeneca I Investigating Significant ICD heart Therapies Malcolm Kirk, M.D. (INSIGHTS). Medtronic I The Effect of Omega-3 Fatty Acids on the Electrophysiology of Chronically Infracted Swine Frederic Christian, M.D. Hearts. Rhode Island Foundation I Atrial High Rate Episodes in Pacemaker Patients. Medtronic Dr. Gideon Koren: I Heart and Muscle K+ Channels: Assembly and Kristin Ellison, M.D. Regulation [NIH/NHLBI] I BLOCK HF Study. Medtronic I Assembly and Trafficking of Cardiac K+ Channels I Optimal Myocardial Electrical Resynchronization [NIH/NHLBI] Study. Medtronic

Dr. Ulrike Mende: I InSync ICD Post market Registry Cardiac I Muscarinic Signaling: Regulation of Ventricular Resynchronization Therapy. Medtronic Function [NIH/NHLBI] I Atrial Synchrononous Biventricular Pacing Device. I Regulation of Cardiomyocyte Signaling and Medtronic Function by Endogenous Regulators of G protein I ENDOTAK RELIANCE G Evaluation of Handling Signaling (RGS Proteins) [AHA] and Electrical Performance. Guidant Corporation I Pacing Evaluation-Atrial Support Study in Cardiac CLINICAL RESEARCH Resynchronization Therapy. Guidant Corporation Paul Gordon, M.D. Jinette Dawn Abbott, M.D. I D.E.S.cover Registry Study. Cordis Corporation I The Evaluation of a Novel Drug Eluting Stent I A Prospective, Randomized Trial Evaluating the That combines a Bioactive Carrier and the Anti- Taxus Paclitaxel-Eluting Coronary Stent in De restenotic Drug Paclitaxel. Biotegra, Inc. Novo Coronary Stent in De Novo Coronary James Arrighi, M.D. Lesions and In-Stent Restenosis. Parexel/BSC I F-18 Fluorodeoxyglucose Uptake on PET for I Pioglitazone Effect on Regression of Intravascular Evaluation of Carotid and Aortic Plaque Sonographic Coronary Obstruction Prospective Instability. Cardinal health Evaluation. Omnicare Clinical Research

19 cardiology

I Tenax XR Registry. Biotronik, Inc. Malcolm Kirk, M.D. I I A Multi-center Registry for the Evaluation of Drug Alternants Before Cardioverter Defibrillator Trial. Eluting Stents and Ischemic Events. Paragon Pacesetter, Inc. a St. Jude Company Biomedical, Inc./Millenium I Device Evaluation of CONTAK RENEWAL 2 and I A Randomized, Double-blind Trial to Assess EASYTRAK 2: Assessment of Safety and TAXUS Paclitaxel-Eluting Coronary Stents, Slow- Effectiveness in Heart Failure. Guidant Corporation Release Formulation, in the Treatment of De Novo Kenneth Korr, M.D. Coronary Lesions. Boston Scientific I Post-dilation Clinical Comparative Study (POS- I A Study to Evaluate the Effect of Rosuvastatin on TIT). Boston Scientific intravascular Ultrasound-Derived Coronary I Left Main Intravascular Ultrasound (IVUS) Atheroma Burden. AstraZeneca Registry. Scripps Research Institute I NIRFLEX U.S. Study. Medinol Ltd. Daniel Levine, M.D. I A Multi-center, Randomized, Double-Blind, I Placebo-Controlled Trial Comparing the Efficacy A Randomized, Double-blind, Placebo Controlled, and Safety of Reteplase and Abciximab combina- Dose-ranging Study of the Effects of KW-3902, tion Therapy with Abciximab alone Administered both as Monotherapy and in Combination with Early or Just Prior to Primary Percutaneous coro- Furosemide, on Diuresis and Renal Function in nary Intervention for Acute Myocardial Infarction patients with congestive Heart Failure (CHF) and (FINESSE). Centocor, Inc. Renal Impairment Treat. Cardiovascular Clinical Studies, L.L.C./Novacardia I A Prospective, Randomized, Double Blind, Multi- I center Study Comparing the Effects of An Open Label Prospective Parallel 6 Month Atorvastatin versus Pravastatin on the Progression Controlled Randomized Multi-center Trial and Quantification of Coronary Atherosclerotic Comparing the Long Term Safety and Efficacy of Lesions as Measured by Intravascular Ultrasound. the Resmed Autoset CS to 2/L Nasal oxygen. Warner-Lambert Company ResMed Corp I Study of Candesartan in Patients with Heart I A Randomized, Controlled Study of the Use of a Central Venous Catheter for Core Cooling and Failure and Preserved Left Ventricular Systolic Rewarming as an Adjunct to Percutaneous Function Coronary Intervention for the Treatment of Acute I SPAN-CHF: A Lifespan Demonstration Project in Myocardial Infarction. Innercool Therapies Disease Management. New England Medical Center I AngioJet Rheolytic Thrombectomy in Patients I Randomized Evaluation of Intravenous Undergoing Primary Angioplasty for Acute Levosimendan Efficacy Versus Placebo in the Short Myocardial Infarction. Possis Medical, Inc. Term Treatment of Decompensated Chronic Heart Failure (REVIVE). MDS Pharma Services Inc. I A Prospective, Randomized Trial Evaluating the Slow Release Formulation TAXUS Paclitaxel- I Follow Up Serial Infusions of Natrecor (nesiritide) Eluting Coronary Stent in the Treatment of In- for the Management of Patients with Heart Failure Stent Restenosis. Boston Scientific FUSION II. Scios Nova, Inc.

I A Prospective, Randomized, Open-label, Multi- George McKendall, M.D. center Study in Patients Presenting with Acute I Early Glycoprotein IIb/IIIa Inhibition in Non-ST- Coronary Syndromes. Aventis Pharmaceuticals segment Elevation Acute Coronary Syndrome: A Products, Inc. Randomized, Placebo-Controlled Trial Evaluating I Comparison of Prasugrel (CS-747) and the Clinical Benefits of Early Front-loaded Clopidogrel in Acute coronary Syndromes Eptifibatide in the Treatment of Patients with Subjects who are to Undergo Percutaneous Non-ST-segment Elevation Acute Coronary Coronary Intervention. Quintiles/Eli Lilly Syndrome. (EARLY ACS). Duke University I A Randomized Trial to Evaluate the Relative Medical Center/Millenium Protection Against Post-PCI Microvascular Dysfunction and Post-PCI Ischemia Among Anti- Platelet and Anti-Thrombotic Agents. Millennium 20 Pharmaceuticals, Inc. brown medical school department of medicine

I A Multi-center, Randomized, Controlled, Double- I The Effect of LDL-Cholesterol Lowering Beyond Blind Trial to Investigate the Clinical Efficacy and Currently Recommended Minimum Targets on Tolerability of Early Treatment with Simvastatin Coronary Heart Disease Reoccurrence in Patients 40 mg. Daily for 30 Days, Followed by Simvastatin with Pre-Existing CHD. IKON 80 mg. Daily Thereafter in Tirofiban-Treated I GUSTO: Global Utilization of Streptokinase and Acute Coronary Syndrome Patients Who Have TPA for Occluded Coronary Arteries. Genetech Been Randomized to Receive Enoxaparin or Unfractionated Heparin in Conjunction with Barry Sharaf, M.D. Aspirin (A to Z). Brigham & Women’s I A Double-Blind, Multicenter, Placebo Controlled Hospital/Merck Study of Quinapril in Women with Chest Pain, Coronary Flow Reserve Limitations and Evidence I A Prospective Randomized Trial of Primary Angioplasty Versus Thrombolytic Therapy for of Myocardial Ischemia in the Absence of Acute Myocardial Infarction in the Elderly Significant Epicardial Coronary. University of (SENIOR PAMI). William Beaumont Institution Florida-Gainesville I Women’s Ischemia Syndrome Evaluation I A Multi-center, Randomized, Double-Blind, Parallel- group, Placebo-controlled Study of Pexelizumab in Extension AT-1 Receptor Blocker Ancillary Trial Patients with Acute Myocardial Infarction Undergoing Angiographic Core Laboratory. University of Primary Percutaneous Coronary Intervention (APEX Pittsburgh/NIH AMI). Procter & Gamble Pharmaceuticals, Inc. I A Double-Blind, Multi-center, Placebo Controlled Study of Quinapril in Women with Chest Pain, I A Prospective, Randomized, Open-Label, Multi- center Study in Patients Presenting with Acute Coronary Flow Reserve Limitations and Evidence Syndromes (ACS) SYNERGY. Aventis of Myocardial Ischemia in the Absence of Pharmaceuticals Products, Inc. Significant Epicardial Coronary Artery Disease. University of Florida-Gainesville I ASSENT 4 PCI A Phase IIIb-IV, Randomized I Open-label Trial Evaluating the Efficacy and Safety Double-Blind, Randomized, Comparator - of Tenecteplase Together with Unfractionated Controlled Study in Subjects with Type 2 Diabetes Heparin Prior to Early PCI As Compared to Mellitus Comparing the Effects of Pioglitazone Standard Primary PCI in Patients With Acute HCI Verus Glimepiride on the Rate of Progression Myocardial Infarction. Boehringer Ingelheim of Coronary Atherosclerotic Disease as Measured by Intravascular Ultrasound (PERISCOPE). I Home Automatic External Defibrillator Trial (H. A. T. Omnicare Clinical Research/Takeda Study). Seattle Institute for Cardiac Research/NHLBI I A Prospective, Randomized Double Blind Multi- I A Randomized, Multicenter Trial of Transcutaneous, Center Study Comparing the Effects of Atorvastatin Low Energy Ultrasound Therapy with Thrombolysis Versus Pravastatin on the Progression and for Patients with Acute Myocardial Infarction. PLUS Quantification of Coronary Atherosclerotic Lesions as Perfusion by ThromboLytic and UltraSound. Henry Measured by Intravascular Ultrasound (REVERSAL). Ford Coordinating Center/Timi3 Systems, Inc. Covalent Group, Incorporated/Warner-Lambert Athena Poppas, M.D. I Vasodilator Induced Stress in Concordance with I Heart Disease CNS Dsyfunction & Outcome in Adenosine (Core Lab). Parexel/King the Elderly. Miriam Hospital/NIH I A Multi-center, Randomized, Double-Blind, I Percutaneous Left Atrial Appendage Transcatheter Placebo Controlled Study to Evaluate the Efficacy Occlusion (PLAATO) Using the X-Caliber System- and Safety of Ad5FGF-4 in Patients with Stable A Feasibility Study (Core). Appriva Medical, Inc. Angina. Berlex Laboratories

Ara Sadaniantz, M.D. Satish Sharma, M.D. I Multi-center, Randomized Double Blind Placebo I Double-Blinded, Randomized Active-Controlled Controlled Efficacy Study on the Effects of Oral Trial Comparing Valsartan to Amlodipine With or Tolvaptan on Left Ventricular Dilatation and Without HCTZ on CV. Novartis Function in Patients With Heart Failure and Left Ventricular Systolic Dysfunction. Cardiovascular Clinical Studies/Otsuka 21 cardiology

I The Effect of Antiarrhythemic Therapy in I A Multi-center, Non-Randomized Study of the Maintaining Stability of Sinus Rhythm in Atrial 4.0mm Sirolimus - Eluting Bx Velocity Balloon- Fibrillation. Department of Veterans Affairs - Expandable Stent in the Treatment of Patients Cooperative Study with DeNovo Native Coronary Artery Lesions. Cordis Corporation Philip Stockwell, M.D. I A Prospective, Randomized Trial Evaluating the I Multi-center, Randomized, Double-blind, Placebo- TAXUS Paclitaxel - Eluting Coronary Stent in De controlled Study to Evaluate the Long Term Novo Coronary Lesions and In-Stent Restenosis. Efficacy and Safety or Oral Tolvaptan Tablets in Parexel/BSC Subjects Hospitalized with Worsening Congestive Heart Failure. Cardiovascular Clinical Studies, I A Multi-Center, Non-Randomized Study of the L.L.C./Otsuka Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent with Direct Stenting in the Treatment of Peter Tilkemeier, M.D. Patients with DeNovo Native Coronary Artery I A Multi-center, Randomized, Double-blind, Lesions. Cordis Corporation Placebo Controlled, Efficacy Study on the Effects I A Multi-center, Randomized, Double Blind Study of Tolvaptan on Left Ventricular Dilatation and of the Sirolimus-Coated Bx Velocity Balloon- Function in Patients with Heart Failure and Left Expandable Stent in the Treatment of Patients Ventricular systolic Dysfunction. Cardiovascular with DeNova Coronary Artery Lesions. Cordis Clinical Studies, L.L.C./Otsuka Corporation I A Randomized, Two-arm Crossover Study of I Percutaneous Left Atrial Appendage Transcatheter Safety, Tolerability, and Myocardial Perfusion Occlusion (PLAATO) Using the X-Caliber System Imaging of MRE0470 vs. Adenosine. Parexel/King Feasibility Study (Clinical). Appriva Medical, Inc. David Williams, M.D. I SVG Protection in a Distal Embolic Protection I Bypass Angioplasty Revascularization Randomized Trial. ev3, Incorporated Investigation II. University of Pittsburgh/NHLBI I The FilterWire EZ System Used in the Treatment I Dynamic Registry of Percutaneous Coronary of an Acute Myocardial Infarction for Embolic Intervention. University of Pittsburgh/NIH Protection Protocol. Boston Scientific I LightLab Imaging Wire. LightLab Imaging, LLC I A Multi-center Trial of Localized Radiation Therapy to Inhibit Restenosis. Cordis Corporation I A Prospective, Randomized, Placebo-Controlled Triple-Masked Trial to Evaluate the Safety and Wen-Chih Wu, M.D. Effectiveness of the Novoste Beta-cath System in I Acute Decompensated Heart Failure National Native Coronary Arteries. Novoste Corporation Registry (ADHERE) 001. Scios, Inc I A Double-Blind, Randomized Comparator Study I Effectiveness of Different Strategies in Comparing the Renal Effects of Visipaque 320 Maintaining Target Goals of Cardiovascular Risk (iodixanol) vs. Optiray 320 (ioversol) in Chronic Factors in Patients. Merck, Inc Stable Renal Failure Subjects Undergoing I The Use of Nesiritide for Treatment of Acute Coronary Angiography (VIS-P4-007). Amersham Decompensated Congestive Heart Failure Corporation Complicated by Acute Renal. Scios, Inc. I D.E.S.cover Registry Protocol. Cordis Corporation

22 brown medical school department of medicine

ENDOCRINOLOGY OVERVIEW

he Division of Endocrinology at Brown Medical School has undergone major expansion with the Tdevelopment of the new Hallett Center for Diabetes and Endocrinology, a Bone Density Unit with state-of-the art diagnostic and osteoporosis management capabilities, an outpatient Clinical Research Unit, and the new Diabetes and Endocrinology Research Laboratories. The Hallett Center was created in 2001 as the first comprehensive, academic diabetes and endocrinology program in the state of Rhode Island. Patient care at the Hallett Center currently is provided by seven board-cer- tified endocrinologists, all of whom have Brown University faculty appointments. The Center already has had more than 20,000 patient visits and is continuing to rapidly expand its services. To assure readily accessible, comprehensive care for patients with diabetes, specialty services are offered within the Center not only in dia- betes and endocrinology, but also in nephrology, podia- try, and weight management. In addition, outpatient programs of the Hasbro Children’s Hospital in pediatric Robert J. Smith, Professor of Medicine; Director, Division of diabetes and endocrinology have been integrated into Endocrinology and the Hallett Center for Diabetes and the Hallett Center facility. A recent evaluation has Endocrinology. shown that the Hallett Center dramatically exceeds researcher on autoimmune causes of thyroid disease. national performance levels and standards for impor- With the addition of these programs, the highly-produc- tant quality of care indicators, such as hemoglobin A1c tive diabetes and endocrine research team in the Division assessment and ophthalmology and podiatric care. The now includes five faculty members directing basic Hallett patient education program has been awarded research groups and six faculty pursuing clinical research. certification status by the American Diabetes The Division of Endocrinology has revised and greatly Association and, through a program developed cooper- strengthened its extensive teaching programs in diabetes atively with the Rhode Island Department of Health, and endocrinology at Brown University, Brown Medical this recently has been extended to an American School, and the affiliated academic hospitals. Four Diabetes Association multi-site center certification that faculty members have been recent recipients of the includes the Hallett Center plus an additional seven Dean’s Excellence in Teaching Awards from Brown satellite patient education units throughout the state. University. In addition to a broad range of classroom Research programs within the Division of and bedside teaching activities, the Division has Endocrinology have been substantially expanded with provided primary training for 20 graduate and post- the arrival of three new research faculty members. The graduate level trainees and multiple undergraduate new faculty include: Nitin Trivedi, MD, a clinician- independent study students during the period covered researcher who is studying mechanisms for improving by this report. The educational program includes a the growth and survival of endogenous or transplanted nationally known, highly selective clinical fellowship in pancreatic beta cells; Haiyan Xu, MD-PhD, a basic sci- Endocrinology, Diabetes, and Metabolism. Of the five entist who is investigating the role of adipose tissue in trainees most recently entering this fellowship, two are mediating inflammatory responses that contribute to graduates of the Harvard/BI Deaconess residency in the complications of obesity and diabetes; and Leslie J. Boston, one is from Yale, one from Brown, and one a DeGroot, MD, who was formerly chief of endocrinology chief resident from the Robert Wood Johnson Program at the University of Chicago and is a world-renowned in New Jersey. 23 endocrinology

FACULTY MEMBERS ADJUNCT FACULTY Douglas P. Kiel, M.D., Ph.D., Adjunct Associate FULL-TIME FACULTY (Hospital and Foundation Based) Professor, Rhode Island Hospital Robert J. Smith, M.D., Director, Professor, Rhode Joseph Tucci, M.D., Adjunct Professor, Island Hospital, University Medicine Foundation Roger Williams Medical Center Linda Bausserman, Ph.D., Associate Professor, The Miriam Hospital NATIONAL AND INTERNATIONAL Dominic Corrigan, M.D., Clinical Assistant Professor, HONORS AND RECOGNITION Rhode Island Hospital, University Medicine Foundation OF FACULTY Leslie J. DeGroot, M.D., Professor of Medicine, Brown University Dominic Corrigan, M.D. Geetha Gopalakrishnan, M.D., Assistant Professor, Invited Presentations: Rhode Island Hospital, University Medicine I “The Gray Zone of Glucocorticoid Insufficiency in Foundation Critical Illness,” Medical Grand Rounds, Rhode James V. Hennessey, M.D., Associate Professor, Island Hospital Associate Director for Clinical Education, Rhode Leslie J. DeGroot, M.D. Island Hospital, University Medicine Foundation Honors and Awards: Marc J. Laufgraben, M.D., Clinical Assistant Professor, I Distinguished Educator Award, The Endocrine Associate Director for Clinical Care, Rhode Island Society Hospital, University Medicine Foundation I Gold Key Award for Distinguished Faculty, Paul Levinson, M.D., Associate Professor, University of Chicago, Pritzger Medical School Memorial Hospital of Rhode Island Professional Society Leadership and Honors: Lu-Guang Luo, M.D., Assistant Professor, I Development Committee, Guidelines Committee, Rhode Island Hospital Chair of Thyroid Disease in Pregnancy Committee, David B. MacLean, M.D., Adjunct Associate Professor, The Endocrine Society Rhode Island Hospital, University Medicine Foundation I Honorary Member, Japanese Endocrine Society Eduardo A. Nillni, Ph.D., Associate Professor, I Education Committee, The American Thyroid Rhode Island Hospital Association Nitin Trivedi, M.D., Assistant Professor, I Member, The Royal Medical Society Rhode Island Hospital, University Medical Foundation Editorial Boards: Haiyan Xu, M.D., Ph.D., Assistant Professor, I The Journal of Clinical Endocrinology and Rhode Island Hospital Metabolism VOLUNTEER FACULTY I Endocrinology Padma Balasubramanian, M.D., Clinical Assistant I Acta Endocrinologica Professor, Rhode Island Hospital I The Journal of Clinical Investigation Lucinda Barnard, M.D., Clinical Assistant Professor, I The Journal of Endocrine Investigation Memorial Hospital of Rhode Island I Metabolism, Clinical and Experimental Robert Dobrzynski, M.D., Clinical Instructor, Invited Presentations: The Miriam Hospital I “Genetic Factors in Graves’ Disease,” Matsumoto, Charles Eil, M.D., Ph.D., Clinical Associate Professor, Japan Roger Williams Medical Center I “Gene Therapy of Thyroid Cancer,” Okinawa, Japan Charles B. Kahn, M.D., Clinical Professor, I “Management of Invasive Thyroid Cancer,” The Miriam Hospital Florianopolis, Brazil Dennis Krauss, M.D., Clinical Assistant Professor, I “Cell Specific Gene Therapy of Thyroid Cancer,” The Miriam Hospital Florianopolis, Brazil Valerie Thomas, M.D., Clinical Assistant Professor, 24 The Miriam Hospital brown medical school department of medicine

I “Causes and Cures of Hyperthyroidism,” The I “When Should the Primary Care MD Refer Patients Miriam Hospital, Providence, RI with Thyroid Nodules to an Endocrinologist?,” Rhode Island Chapter, American College of Physicians, 2003 Geetha Gopalakrishnan, M.D. Internal Medicine Update, Newport, RI Honors and Awards: I “Pharmacokinetic vs. Pharmacodynamic I Best Doctor, Better Living Magazine Determination of Bioequivalence: Some History and Professional Society Leadership and Honors: Current Reality,” Controversies in Thyroid Hormone I HIV Prevention Trials Network Perinatal Working Treatment Symposium, Annual Meeting of the Group, AIDS Clinical Trial Group American Association of Clinical Endocrinologists I Chairman, Rhode Island Osteoporosis Coalition (AACE), Boston, MA Advocacy Committee I Program Chair and Conference Moderator, Rhode I Surveillance Committee, Rhode Island Island American College of Physicians 2004 Osteoporosis Coalition Annual Meeting, Warwick, RI Editorial Boards: I Program Chair and Conference Moderator, Rhode I Section Editor, Ferri’s Clinical Advisor 2005 Edition Island American College of Physicians 2004 Annual Invited Presentations: Internal Medicine Update, Newport, RI I “Update on Osteoporosis,” Medical Grand Rounds, I “Update on the Endocrinology of Critical Illness: Rhode Island Hospital Thyroid, Gonadal, and Growth Hormone Axes in I “Postmenopausal Osteoporosis,” Healthy Aging Critical Illness,” Medical Grand Rounds, Rhode Conference, Providence, RI Island Hospital I “Osteoporosis: Overview,” Rhode Island I “Thyroid Disease Update 2005: Subclinical Hypo Osteoporosis Coalition Workshop, Providence, RI and Hyperthyroidism,” Ft. Lauderdale, FL I “Bone Health in Postmenopausal Women,” I “Thyroid Hormone Therapy 2005, Update in Women’s Wellness Workshop, Providence, RI Current Bioequivalence Issues,” Charlotte, NC

I “Bone Health in Women,” Staff Development Day, Marc J. Laufgraben, M.D. Brown University, Providence, RI Professional Society Leadership and Honors: I James V. Hennessey, M.D. Clinical and Practice Management Initiative Honors and Awards: Committee, American Association of Clinical Endocrinologists I Listed in Who’s Who in Medicine and Healthcare I Professional Society Leadership and Honors: Co-Chair, Rhode Island Chronic Care Collaborative, sponsored by the Robert Wood Johnson Foundation I Governor, Rhode Island Chapter, American College of Physicians via the Improving Chronic Illness Care Program; the Rhode Island Department of Health via the Diabetes I Executive Board Member, Thyroid Foundation of Control Program; and Rhode Island Quality Partners. America I Third Party Reimbursement Negotiations Task I Education Committee, American Thyroid Association Force, University Medicine Foundation I Public Health Committee, American Thyroid I Endocrinology Specialty Advisory Committee Association Blue Cross Blue Shield of Rhode Island I Advisor, American Thyroid Association I Fellow, American College of Physicians Invited Presentations Invited Presentations: I Program Chair and Moderator, Rhode Island I “Hey Doc, What Are These Pills For?,”Diabetes and American College of Physicians 2003 Annual Sight Awareness Community Health Day, Cranston, RI Meeting, Warwick, RI I “The ABC’s of Great Diabetes Care,” Diabetes and I “Thyroid Nodules and Osteoporosis Updates 2003,” Sight Awareness Day, Cranston, RI Rhode Island Academy of Family Practice Annual I Update, Groton, CT “Combination Therapy for Type 2 Diabetes,” Medical Grand Rounds, Rhode Island Hospital I “SERM use in the Medical Patient Post Menopause,” I Medical Grand Rounds, Hartford Hospital, “Update on the Metabolic Syndrome,” Staff Grand Rounds, South County Hospital, Wakefield, RI Hartford, CT 25 endocrinology

I “Caring for Adults with Diabetes,” Plenary Invited Presentations: Lecture, Rhode Island Chronic Care Collaborative, I “Regulation of the Hypothalamic Prohormone CME Learning Session, Warwick, RI Convertases 1 and 2 Expression by Fasting and I “Type 2 Diabetes Update: New Options, Better Leptin,” University of South Florida, FL Outcomes,” Medical Grand Rounds, Newport I “The CPEfat Mouse, a Model of Cold Stress,”Yale Hospital, Newport, RI University, CT I “ALLHAT and All That: Managing Hypertension I “ProThyrotropin Releasing Hormone (proTRH) in Patients with Diabetes,” Rhode Island Chronic Processing and Trafficking,” Gordon Research Care Collaborative, CME Learning Session, Conference, Mount Holyoke College, MA Providence, RI I “The Biology of Prothyrotropin Releasing I “Right from the Start: Diabetes Screening and Hormone (ProTRH), a Multifunctional Protein,” Initial Management,” Rhode Island Chronic Care International Peptide Conference, Miami, FL Collaborative, CME Learning Session, Warwick, RI I “Hypothalamic Peptides Controlling Energy I “Progressive Therapy for Type 2 Diabetes,” Expenditure,” Pediatric Research Colloquium, Department of Medicine, Community Based Providence, RI. Preceptors Welcoming Dinner, Brown Faculty I Chair and speaker, “Central Nervous System Club,Providence,RI Pathways Controlling Nutrient Sensing,” Annual I “Management of Diabetes in Hospitalized Meeting of the Endocrine Society, San Diego, CA Patients,” Hospital Wide Grand Rounds, Rhode I “The Role of Leptin in the Stimulation of the Island Hospital ProTRH Neurons through Direct and Indirect I “Insulin: Yesterday, Today and Tomorrow,” Pathways,” Annual Meeting of the Endocrine Medical Grand Rounds, Rhode Island Hospital Society, San Diego, CA I “Advanced Glycemic Management in Type 2 Robert J. Smith, M.D. Diabetes,” Comprehensive Care of the Diabetic Professional Society Leadership and Honors: Patient, American College of Physicians 2004 Rhode I Planning Committee, 2nd Joint Symposium of the Island Chapter Regional Meeting, Warwick, RI Growth Hormone Research Society and the International Society for IGF Research, Cairns, Eduardo A. Nillni, Ph.D. Australia Professional Society Leadership and Honors: I I Bruce Selya Award Committee, Lifespan Planning Committee, NIH Symposium on Insulin Therapy in Critical Illness I Special Emphasis Panel, Endocrinology and Metabolism Study Section, NIH I Special Programs Committee, The Endocrine Society I I Executive Committee, Department of Molecular Chair, Clinical Endocrinology Update Committee, Biology, Cell Biology and Biochemistry, Brown The Endocrine Society University I Board of Directors, New England Chapter-Rhode I Medical Faculty Executive Committee, Brown Island Branch, Juvenile Diabetes Research Medical School Foundation International I I Ad Hoc Reviewer, Endocrinology and Committee Member and Vice President, Brown Reproductive & Nutritional and Metabolic University Medical Faculty Executive Committee Sciences Study Section, NIH I Brown University Ship Street Biomedical Research I Ad Hoc Reviewer, Integrative Physiology of Building Committee Obesity and Diabetes Study Section, NIH I LCME Task Force and Institutional Setting I Ad Hoc Reviewer, Molecular and Developmental Subcommittee, Brown Medical School and Cellular Neuroscience-1 Study Section, NIH I Internal Advisory Committee, COBRE Center for I Member, Canada Research Chairs Program Cancer Research Development at Rhode Island College of Reviewers, Canada Institutes of Health Hospital Editorial Boards: I Planning Committee, Annual Research Celebration, I Endocrinology Lifespan Rhode Island Academic Medical Center 26 brown medical school department of medicine

I Chair, Diabetes Professional Advisory Council, I “The Grb10 Adapter Protein in Insulin and IGF Rhode Island Department of Health Signaling,” Department of Biochemistry Research I Providence Professional Advisory Council, Seminar, University of Bath, UK American Diabetes Association I “Role of the Grb10 Adapter Protein in Insulin and Editorial Boards: IGF Signaling,” Brown Gastroenterology Division I Endocrinology Basic Research Seminar I I Journal of Biological Chemistry “Heterozygous IGF-I Receptor Mutations in Humans,” Gordon Conference on Insulin-like I UpToDate Growth Factors, Ventura, CA I Journal of Parenteral and Enteral Nutrition I “Role of Receptor-Interactive Proteins That Are I Journal of Growth Hormone and IGF Research Not Tyrosine Kinase Substrates,” 2nd International Invited Presentations: Conference on Molecular Basis of Metabolic I “Insulin and Glucose Management in the Diabetic Regulation, University of Bari, Italy Surgical Patient,” Surgical Grand Rounds, Rhode Island Hospital Nitin Trivedi, MD Professional Society Leadership and Honors: I “Type 2 Diabetes and the Metabolic Syndrome: I American Diabetes Association, Council on Diagnosis, Treatment, and Prevention,” Keynote Immunology and Transplantation Lecture, Brown Medical School Department of Medicine Update in Internal Medicine, Providence, RI Haiyan Xu, M.D., Ph.D. I “Diabetes Mellitus in the Elderly,” Geriatrics Invited Presentation: Fellowship Program Lecture, Brown Medical I “Adipose Inflammation Plays an Important Role in School, Providence, RI Obesity-Related Insulin Resistance and Type 2 I “Diabetes Update,” Invited Speaker, American Diabetes,” Harvard School of Public Health Diabetes Association Community Leaders Breakfast, Nutrition Seminar Series, MA Providence, RI I “Diabetes Management of the Surgical and Medically TEACHING ACTIVITIES Acute Patient,” Contemporary Topics in Nutrition: 13th Annual Nutrition Symposium, Rhode Island EDUCATION HONORS Hospital, Providence, RI Geetha Gopalakrishnan, M.D. I “The Metabolic Syndrome,” Rhode Island Chapter I Dean’s Teaching Excellence Award from Brown of the American College of Physicians Regional Medical School Conference, Warwick, RI I “The Metabolic Syndrome Epidemic: What Should We James V. Hennessey, M.D. Do and Why Do We Care?,”Medical Grand Rounds, I Dean’s Teaching Excellence Award from Brown Memorial Hospital of Rhode Island, Pawtucket, RI Medical School I “What Should We Do About the Metabolic Marc J. Laufgraben, M.D. Syndrome?,” Medical Grand Rounds, St. Luke’s I Dean’s Teaching Excellence Award from Brown Hospital, New Bedford, MA Medical School I “Diabetes: How New Research and Innovative Care is Helping Rhode Island,” Brown University Trustees Paul Levinson, M.D. I I “Of Mice and Medicine: Connecting Molecular Dean’s Teaching Excellence Award from Brown Science and Human Health,” Brown University Medical School Trustees TEACHING RESPONSIBILITIES I “Decreased Growth and IGF-I Responsiveness in Humans Heterozygous for IGF-I Receptor Lectures to Medical Housestaff Mutations,” 2nd International Symposium on Dominic Corrigan, M.D. Growth Hormone and Insulin-like Growth Geetha Gopalakrishnan, M.D. Factors, Cains, Australia James V. Hennessey, M.D. 27 endocrinology

Marc J. Laufgraben, M.D. SELECTED PUBLICATIONS Robert J. Smith, M.D. Nitin Trivedi, M.D. Leslie J. DeGroot, M.D. I Kon YC, DeGroot LJ. Painful Hashimoto’s thyroiditis Endocrinology Teaching Attending Rounds as an indication for thyroidectomy: Clinical charac- Dominic Corrigan, M.D. teristics and outcome in seven patients. J Clin Geetha Gopalakrishnan, M.D. Endocrinol Metab, 88:2667-2672, 2003. James V. Hennessey, M.D. I Takara M, Kouki T, DeGroot LJ. CTLA-4 AT-repeat polymorphism reduces the inhibitory function of Marc J. Laufgraben, M.D. CTLA-4 in Graves’ disease. Thyroid, 13:1083-1089, Robert J. Smith, M.D. 2003. Nitin Trivedi, M.D. I DeGroot LJ. “Nonthyroidal illness syndrome” is Joseph Tucci, M.D. functional central hypothyroidism, and if severe, hor- mone replacement is appropriate in light of present Medical Residency Teaching Attending knowledge. J Endocrinol Invest 26:1163-1170, 2003. James Hennessey, M.D., Rhode Island Hospital I Yamazaki M, Straus FH, Messina M, Robinson BG, Paul Levinson, M.D., Memorial Hospital of Rhode Takeda T, Hashizume K, DeGroot LJ. Adenovirus- Island mediated tumor-specific combined gene therapy using herpes simplex virus thymidine/ganciclovir Brown Medical School Pathophysiology Course system and murine interleukin-12 induces antitu- James V. Hennessey, M.D., Director mor activity against medullary thyroid carcinoma. Cancer Gene Therapy, 11:8-15, 2004. Dominic Corrigan, M.D., Participant I DeGroot LJ, Zhang R. Viral mediated gene therapy Geetha Gopalakrishnan, M.D., Participant for management of metastatic thyroid carcinoma. Marc J. Laufgraben, M.D., Participant In: Current Drug Targets, Immune Endocr Metabol Paul Levinson, M.D., Participant Disord, 4:235-244, 2004 Robert J. Smith, M.D., Participant Paul Levinson, M.D. Nitin Trivedi, M.D., Participant I Levinson, PD. Eighty years of insulin therapy: Joseph Tucci, M.D., Participant 1922-2002. Medicine and Health/Rhode Island 86: 101-106, 2003. Molecular Biology, Cell Biology and Biochemistry Graduate Program Faculty Geetha Gopalakrishnan, M.D. Eduardo A. Nillni, Ph.D. I Marcus R and Gopalakrishnan G. Secondary forms of osteoporosis. In Coe, F.L., and Favus, M.J., Eds. Robert J. Smith, M.D. Disorders of Bone and Mineral Metabolism. (Accepted to Raven Press). Pathobiology Graduate Program Faculty Eduardo A. Nillni, Ph.D. James V. Hennessey, M.D. Robert J. Smith, M.D. I Hennessey JV. L-Thyroxine a new drug? Since when? How could that be? Thyroid 2003; 13 (3):279-282. Undergraduate Honors Thesis Advising I Hennessey JV. Precise Thyroxine dosing: Clinical Eduardo A. Nillni, Ph.D. requirements. The Endocrinologist 2003; 13 Robert J. Smith, M.D. (6):479-487. I Garber JA, Hennessey JV. Generic levothyroxine: What is all the fuss about? Endocrine Practice 2005; 11 (3):205-7. I Hennessey JV. Psychiatric disorders and thyroid disease. Endocrine Secrets, Fourth Edition. MT McDermott ed. Hanley & Belfus, Inc. Philadelphia 2005 28 brown medical school department of medicine

I Hennessey JV. Physical examination of the thy- J, Kratzsch J, Osgood D, Pfaffle R, Ralle K, Seidel B, roid. In the Thyroid a Fundamental and Clinical Smith RJ, Chernausek SD. IGF-I receptor mutations Text. Braverman, L. E. and Utiger, R. D. Eds. resulting in intrauterine and postnatal growth Lippincott Williams & Wilkins Publishers retardation. N Engl J Med 2003; 349: 2211-2222. Philadelphia 2005 I Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, Trippel SB. Mechanical regulation of mito- Marc J. Laufgraben, M.D. gen-activated protein kinase signaling in articular I Laufgraben, MJ. Managing diabetic dyslipidemia. cartilage. J Biol Chem 2003; 278: 50940-50948. Medicine and Health/Rhode Island 2003; 86:112-115. I Smith RJ. Diabetes mellitus: a 2003 perspective. David B. MacLean, M.D. Med Health RI. 2003;86:92-95. I Lu-Guang, L and MacLean, DB, Effects of thyroid I Ling PR, Smith RJ, Kie S, Boyce P, Bistrian B. Effects hormone on food intake, hypothalamic Na/K of protein malnutrition on IL-6- mediated signaling ATPase activity and ATP content, Brain Research. in the liver and the systemic acute response in rats. 973(2):233-9, 2003. Am J Physiol, 2004; 287: R801-R808. I MacLean, DB and Lu-Guang, L Increased ATP I Mori K, Giovannone B, Smith RJ. Distinct Grb10 content/production in the hypothalamus may be a Domain Requirements for Effects on Glucose signal for energy-sensing of satiety: studies on the Uptake and Insulin Signaling. Mol Cell Endocrinol anorectant mechanism of a plant steroidal glyco- 2005; 230: 39-50. side, Brain Research, 1020:1-11, 2004. I Lynch JA. Grigoryan M. Fierlinger A. Guermazi A. Nitin Trivedi, M.D. Zaim S. MacLean DB. Genant K. Measurement of I Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, changes in trabecular bone at fracture sites using Bonner-Weir S, Weir GC. Critical reduction in X-ray CT and automated image registration and beta-cell mass results in two distinct outcomes over processing. Journal of Orthopaedic Research. time: adaptation with impaired glucose tolerance or 22(2):362-7, 2004. decompensated diabetes. J Biol Chem 2003;278(5):2997-3005. Eduardo A. Nillni, Ph.D. I Omer A, Duvivier-Kali V, Trivedi N, Wilmot K, I Huo L, Munzberg H, Nillni EA, Bjorbaek C. Role of Bonner-Weir S, Weir GC. survival and maturation Signal Transducer and Activator of Transcription 3 of microencapsulated porcine neonatal pancreatic in Regulation of Hypothalamic trh Gene Expression cell clusters transplanted into immunocompetent by Leptin. 2004. Endocrinology. 145, 2516-2523. diabetic mice. Diabetes 2003;52(1):69-75. I Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, I Tartarkiewicz K, Lopen-Avalos MD, Yoon KH, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Trivedi N, Quickel RR, Bonner-Weir S, Weir GC. Nillni EA. Regulation of hypothalamic prohormone Development and retroviral transduction of convertases 1 and 2 and effects on processing of porcine neonatal pancreatic islet cells in monolayer prothyrotropin-releasing hormone. J Clin Invest. culture. Dev Growth Differ 2003;45(1):39-50. 2004 Aug; 114(3): 357-69. I Guo L, Munzberg H, Stuart RC, Nillni EA, Bjorbaek Haiyan Xu, M.D., Ph.D. C. N-acetylation of hypothalamic alpha- I Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, melanocyte-stimulating hormone and regulation by Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. leptin. Proc Natl Acad Sci U S A. 2004 Aug Chronic inflammation in adipose tissue plays a cru- 10;101(32):11797-802. cial role in the development of obesity-related insulin resistance. J Clin Invest 112 (12):1821- 1830, 2003. Robert J. Smith, M.D. I Xu H, Dembski M, Yang Q, Yang D, Moriarty A, I Giovannone, B, Lee E, Laviola L, Giorgino F, Tayber O, Chen H, Kapeller R, Tartaglia LA. Dual Cleveland, KA, Smith RJ. Two novel proteins that specificity MAP kinase phosphatase-4 plays a are linked to insulin-like growth factor-I (IGF-I) potential role in insulin resistance. The Journal of receptors by the Grb10 adapter and modulate IGF-I Biological Chemistry 278 (32):30187-30192, 2003. signaling. J Biol Chem 2003; 278: 31564-31573. Listings are limited to the 5 most recent publications per I Abuzzahab MJ, Schneider A, Goddard A, faculty member. Grigorescu F, Lautier C, Keller E, Kiess W, Klammt 29 endocrinology

ENDOCRINOLOGY FELLOWSHIP PROGRAM Departing Fellows Name Medical School/Residency Program Post-Fellowship Plans Nitin Trivedi MGM Medical College, India Assistant Professor of Medicine St. Vincent’s Hospital, Worcester Brown University Aldona Finkle Medical University, Gdansk, Poland Private Practice, MA Umass Memorial Health Care, Worcester, MA Maeve Durkan The Royal College of Surgeons Clinical Faculty, University College Ireland/The Hospital at St. Raphael Galway, Ireland New Haven, CT Current Fellows Name Medical School Residency Program Elaine Pelley Loma Linda University School of Medicine BI- Deaconess Harvard Medical School, MA Suketu Shah UMDNJ New Jersey Medical School BI-Deaconess Harvard Medical School, MA Rebecca Lifchus- Robert Wood Johnson Medical School Robert Wood Johnson Ascher Medical School, NJ Post-Doctoral Research Fellows Barbara Giovannone, PhD, Jorge Goldstein, PhD, Katsuhito Mori, MD, PhD, Gregory Fox, MD, Anke Schmidt, MD, Caroline Savery, PhD, Corinne Lautier, PhD, Mario Perello, PhD, Amparo Romero Pico, PhD, Hidefume Inaba, MD, Yun Jae Chung, MD Ph.D. Thesis Graduate Students Aimee Hebert, PhD, Lawrence Mulcahy, PhD, William Tsiaras, MD, PhD

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $856,682 $261,092 $1,117,774 for Endocrinology Academic Year 2004 $440,163 $131,540 $571,703

Total Clinical Research Expenses Academic Year 2003 $223,189 $55,357 $278,546 for Endocrinology Academic Year 2004 $38,700 $7,418 $46,118

BASIC RESEARCH Eduardo Nillni, Ph.D. I The Role of Prepro TRH-Derived Peptides in Cocaine Lu Guang Luo, M.D. Action. University of Connecticut Health Center I Effects of New Drug Candidates on Metabolism of I Research Supplements for Underrepresented Rats In Vivo and In Vitro. Pfizer Incorporated Minorities. National Institute of Neurological I Thyrotropin Releasing Hormone (TRH) in the Disorders & Stroke Alzheimer Hippocampus. Alzheimer’s Association I ProTRH Gene Transcription and Biosynthesis by Leptin. National Institutes of Diabetes, Digestive and Kidney Diseases 30 brown medical school department of medicine

I ProTRH Sorting to the Regulated Secretory I Attenuation of Muscle Wasting with Growth Pathway. National Institute of Neurological Hormone. Cell Based Delivery Disorders & Stroke Douglas Kiel, M.D. I Regulation of Hypothalamic POMC by Leptin. I An 18-Month Double-Blind, Placebo-Controlled, Beth Israel Deaconess Medical Center/NIH Phase III, Trial with a 12-Month Interim Analysis Robert Smith, M.D. of the Effect of Recombinant Human Parathyroid I Mentor-Based Postdoctoral Fellowship Program. Hormone (ALX1-11-93001) on Fracture Incidence American Diabetes Association in Women with Postmenopausal Osteoporosis. NPS Allelix Corp. I Nitin Trivedi Lilly Fellowship. Eli Lilly and Company I A Multi-center Prospective Study to Assess the Impact of Physician’s Reinforcement on the I Nutrition, Cytokines and Anabolic Signaling Subject’s Compliance and Persistence on Treatment Mechanisms. National Institute of Diabetes and using Feedback on Bone Markers in Previously Digestive and Kidney Diseases Undiagnosed Post Menopausal Osteoporatic I Role of GRB10 As An Insulin Receptor Adapter Women Treated with Risedronate. Hoechst Marion Protein. National Institute of Diabetes and Roussel Digestive and Kidney Diseases I A Study of the Safety and Efficacy of Lasofoxifene for the Prevention of Bone Loss and for Lipid CLINICAL RESEARCH Lowering. Pfizer I Teriparatide Compared with Alendronate on Spine James Hennessey, M.D. Bone Mineral Density in Postmenopausal Women I A Randomized Multi-Center Parallel Group Study with Osteoporosis. Eli Lilly and Company to Determine if Knowledge of Baseline Vertebral I An 18 Month Open Label Extension Study (OLES) Fracture Prevalence (As Determined by Hologic of the Safety and Efficacy of Recombinant Human IVA) and Bone Turnover Marker Levels Improves Parathyroid Hormone, rhPTH(1-84), ALX1-11, in Persistence with Actonel 5 mg daily Therapy in Women with Postmenopausal Osteoporosis who Subjects Receiving Glucocorticoids. Aventis Participated in Protocol ALX1-11-93001. NPS Pharmaceuticals Products, Inc. Allelix Corp. I A 2-Year Randomized, Multi-Center, Double-Blind, Placebo-Controlled Study to Determine the Marc Laufgraben, M.D. Efficacy and Safety of Intravenous Zoledronic Acid I A One-Year, Open, Randomized, Parallel, Three-Arm 5 mg Administered Either Annually at Study, Comparing Exubera (Insulin Dry Powder Randomization and 12 Months or Administered at Pulmonary Inhaler) vs. Avandia (Rosiglitazone Randomization only in the Prevention of Bone Loss Maleate) as Add-on Therapy vs. Exubera in Postmenopausal Women with Osteopenia. Substitution of Sulfonylurea in Patients with Type 2 Novartis Pharmaceuticals Corporation Diabetes, Poorly Controlled on Combination Sulfonylurea and Metformin Treatment. Pfizer I A Multi-center, Double-Blind, Randomized, Incorporated Placebo-and Active-Controlled Dose-Range Finding Study of L-000224715 in Patients with I An Assessment of the Calcimimetic Agent AMG Type 2 Diabetes Mellitus Who have Inadequate 073 for the Treatment of Subjects with Parathyroid Glycemic Control. Merck & Company Carcinoma or Intractable Primary Hyperparathyroidism. Amgen I Teriparatide Compared with Alendronate on Spine Bone Mineral Density in Postmenopausal Women I Bypass Angioplasty Revascularization Investigation with Osteoporis. Lilly Research Lab 2 Diabetes (Bari-2D). NIH

I A Multi-center, Double-Blind, Randomized, Placebo- Robert Smith, M.D. Controlled Study to Evaluate the Safety and Efficacy I Bypass Angioplasty Revascularization Investigation of Zoledronic Acid in the Treatment of Osteoporosis 2 Diabetes (Bari-2D). NIH in Postmenopausal Women Taking Calcium and Vitamin D. Novartis Pharmaceuticals Corporation 31 gastroenterology

GASTROENTEROLOGY OVERVIEW

he Division of Gastroenterology at Brown University extends to Rhode Island, Miriam, TWomen and Infants, and Veteran’s Administration Hospital(s). The major missions of the Division are to provide state-of-the-art treatment to those with gas- trointestinal and liver diseases; to educate undergradu- ates, medical students/residents, postdoctoral fellows in the pathophysiology of digestive diseases, and to engage in “cutting-edge” basic and applied research. The Rhode Island Hospital Endoscopy Suite is equipped with the latest technological advances, and accommodates con- sultations from Southeastern Massachusetts, Cape Cod, Connecticut, and Rhode Island. The Liver Research Center, and Swallowing/ Motility Research Center are located on the Rhode Island Hospital campus, and are staffed with twelve principal investigators, twenty-five postgraduate physician/scientists, and twenty under- graduate/graduate students providing a strong basic science program to advance the understanding of dis- ease processes at the cellular and molecular level. N.I.H. Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg-Artemis sponsored projects include: motility and signal trans- and Martha Joukowsky Professor in Gastroenterology and duction of the G.I. tract, H. pylori in gastric cancer, Professor of Medical Science;Director, Division of pathogenesis of NASH, molecular mechanisms of Gastroentoerology and Liver Research Center hepatic fibrosis, antiviral approaches to hepatitis B and FACULTY MEMBERS C infection, molecular pathogenesis of human hepato- cellular carcinoma, and monoclonal antibodies in the FULL-TIME FACULTY (Hospital and Foundation-Based) treatment of G.I. malignancy. Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg-Artemis and Martha Joukowsky Professor RESEARCH in Gastroenterology and Professor of Medical Science; Director, Division of Gastroenterology and Faculty in the Division of Gastroenterology hold varied the Liver Research Center, Rhode Island, Miriam, and N.I.H., N.S.F., corporate, foundation, and pharmaceutical Providence Veteran’s Administration Hospital(s), and grants to support basic and translational research University Medicine (Gastroenterology) Foundation. activities. Fifty faculty publications appeared in highly Gyorgy Baffy, M.D., Assistant Professor, Rhode Island respected, peer-review journals in the past year. Hospital, University Medicine (G.I.) Foundation. Jose Behar, M.D., Professor, Rhode Island Hospital, TEACHING University Medicine (G.I.) Foundation. The Brown University Fellowship Program in Piero Biancani, Ph.D., Professor of Medicine Gastroenterology is a three-year A.C.G.M.E./A.B.I.M. (Research), Rhode Island Hospital. accredited program conducted by thirteen fulltime Weibao Cao, M.D., Assistant Professor, Department and twenty-seven volunteer faculty stationed at the Medicine & Surgery, Rhode Island Hospital Rhode Island, Miriam, Women and Infants, and Suzanne de la Monte, M.D., MPH., Professor of Veteran’s Administration Hospital(s). Individuals are Pathology and Laboratory Medicine (Res) and encouraged to select the Clinical-Scholar, Physician- Clinical Neuroscience, Rhode Island Hospital Scientist, or Research track; mentors of varied Silvia Degli-Esposti, M.D., Assistant Professor of interests are on-site to assist Fellows allowing a 32 Medicine, Womens and Infants Hospital unique clinical/research perspective. brown medical school department of medicine

Ramy Eid, M.D., Assistant Professor, Veteran’s Neil Greenspan, M.D., Clinical Assistant Professor, Administration Medical Center, University Medicine Memorial Hospital (G.I.) Foundation Edward Iannuccilli, M.D., Clinical Professor, Edward Feller, M.D., Clinical Professor, Miriam Hospital Rhode Island Hospital Pierre Gholam, M.D., Assistant Professor, Veteran’s Donald Kaufman, M.D., Clinical Assistant Professor, Administration Medical Center, University Medicine Memorial Hospital (G.I.) Foundation Sheldon Lidofsky, M.D., Clinical Assistant Professor, Fadlallah Habr, M.D., Assistant Professor, Rhode Rhode Island Hospital Island Hospital, University Medicine (G.I.) Foundation James Manis, M.D., Clinical Associate Professor Karen M. Harnett, Ph.D, Assistant Professor, Emeritus, VA Medical Center Rhode Island Hospital Peter Margolis, M.D., Clinical Assistant Professor, Sripathi Kethu, M.D., Assistant Professor, Rhode Rhode Island Hospital Island Hospital, University Medicine (G.I.) Foundation Philip McAndrew, M.D., Clinical Instructor, Miran Kim, Ph.D, Assistant Professor of Medicine, Rhode Island Hospital The Liver Research Center Michael Nissensohn, M.D., Clinical Instructor, Ji-su Li, M.D., Ph.D., Assistant Professor, Miriam Hospital The Liver Research Center Kevin Palumbo, M.D., Clinical Instructor, Steven Moss, M.D., Associate Professor, Rhode Island Rhode Island Hospital Hospital, University Medicine (G.I.) Foundation Theodore C. Palumbo, M.D., Clinical Instructor, Kittichai Promrat, M.D., Assistant Professor, Veteran’s Rhode Island Hospital Administration Medical Center, University Medicine Daniel Quirk, M.D., M.P.H., Clinical Assistant (G.I.) Foundation Professor, Rhode Island Hospital Harlan Rich, M.D., Associate Professor, Rhode Island Herbert Rakatansky, M.D., Clinical Professor, Hospital, University Medicine (G.I.) Foundation Miriam Hospital Shuping Tong, M.D., Ph.D., Assistant Professor, Thomas Sepe, M.D., Clinical Professor, The Liver Research Center Rhode Island Hospital VOLUNTEER FACULTY Samir Shah, M.D., Clinical Assistant Professor, Miriam Hospital Paul Akerman, M.D., Clinical Assistant Professor, Rhode Island Hospital Jay Sorgman, M.D., Clinical Assistant Professor, Miriam Hospital Nicholas Califano, M.D., Clinical Associate Professor, Rhode Island Hospital Joel Spellun, M.D., Clinical Assistant Professor, Rhode Island Hospital Thomas DeNucci, M.D., Clinical Assistant Professor, Rhode Island Hospital Walter Thayer, M.D., Professor of Medicine Emeritus, Rhode Island Hospital Christy L. Dibble, D.O., Clinical Assistant Professor, Women & Infants Hospital Philip Torgan, M.D., Clinical Associate Professor Emeritus, Miriam Hospital Joseph DiMase, M.D., M.S., Clinical Assistant Professor Emeritus, Rhode Island Hospital Paul vanZuiden, M.D., Clinical Assistant Professor, Rhode Island Hospital

FACULTY TRANSITIONS Departed Faculty

Zixu Mao, M.D., Ph.D Assistant Professor of Medicine, Research Zuo-Liang Xiao, M.D., Ph.D Assistant Professor of Medicine, Research

33 gastroenterology

NATIONAL AND INTERNATIONAL Piero Biancani, Ph.D HONORS AND RECOGNITION I Speaker - “The relationship of esophagitis to OF FACULTY esophageal motility dysfunction in a feline model International Symposium on O.E.S.O. Paris, France, September 2003. Gyorgy Baffy, M.D. Reviewer: Reviewer: I Gastroenterology I Alcoholism: Clinical and Experimental Research I American Journal of Physiology I FEBS Letters Presentations: I Nature Medicine I American Gastroenterological Association – Presentations: Orlando, Florida - 2003 I Moderator - Annual Meeting of the Hungarian Medical Association of America – FL, October 03 – In vitro model of acute esophagitis in the cat. - Hepatitis C: Minisymposium “Poster of Distinction” Presentation Rho kinase and cat Lower Esophageal Sphincter I Speaker - University of Debrecen, Hungary, November 2003 – On the biological functions of (LES) tone. -Poster Presentation uncoupling protein-2 Integrin-linked kinase and ACh-induced con- traction of cat esophageal circular muscle. - I Moderator - Annual Meeting of the Hungarian Medical Association of America – Fl, October 04 – Poster Presentation Obesity and colon cancer: it insulin resistance to Role of PGE2 in maintenance of tonic contrac- blame?Jose Behar, M.D. tion of guinea pig gallbladder. -”Poster of Distinction” Presentation I Chairman, Biliary and Pancreatic Section, Rome (Multinational Workshop Team) 2001-6 Pancreatic (Group 1B) phospholipase A2 in the Reviewer: lower esophageal sphincter. -Poster Presentation I Gastroenterology I American Gastroenterological Association – New Orleans, Louisiana – 2004 I American Journal of Physiology Presentations: HCl-induced PAF and IL-6 in a cat in vitro model of acute esophagitis. -Oral Presentation I Nineteenth International Symposium on Neurogastroenterology and Motility – Barcelona, Rho kinase mediates thromboxane A2-induced Spain – 2003 sustained contraction in cat lower esophageal Smooth Muscle Abnormalities in Female Patients sphincter.-Poster Presentation. with Chronic Constipation Due to Colonic Inertia HCl-induced IL-6 and H2O2 in cat LES in an in vitro model of experimental esophagitis. -Poster I American Gastroenterological Association – New Orleans, LA - 2004 Presentation. Role of caveolin-3 proteins in the cholesterol Weibiao Cao, M.D. induced impaired human gallbladder contraction Reviewer: in response to CCK-8 I Gastroenterology HCI-induced PAF and IL-6 in a cat in vitro I American Journal Physiology model of acute esophagitis. I Gastrointest Liver Physiol An increase in cystosolic calcium mediates acid- I J Pharmacol Exp Ther induced prostaglandin E2 production in I Biochemical Pharmacology Barrett’s esophagus I BMC Gastroenterology Rho kinase mediates thromboxane A2 (TXA2)- induced sustained contraction in cat LES HCI-induced IL-6 and H2O2 in cat LES in an in vitro model of experimental esophagitis

34 brown medical school department of medicine

Presentations: Platelet activating factor (PAF) affects esophageal I American Gastroenterological Association – New circular smooth muscle contraction in a human Orleans, LA – May, 2004 in vitro model of acute esophagitis. –Poster pres- An increase in cytosolic calcium mediates acid- entation (Distinguished abstract) induced prostaglandin E2 production in Barrett’s I American Association for Cancer Research – esophagus. –Poster presentation (Distinguished Anaheim, CA – April, 2005 abstract) Role of NADPH oxidase NOX5 in the develop- Mucosal production of tumor necrosis factor ment of Barrett’s adenocarcinoma cells. – Poster (TNF)-alpha and interleukin (IL)-1beta induces presentation sigmoid smooth muscle cells to produce hydro- gen peroxide (H2O2) in ulcerative colitis (UC) Suzanne de la Monte, M.D., M.P.H. –Poster presentation Reviewer: I Journal of Alzheimer’s Disease Rho kinase mediates thromboxane A2-induced I sustained contraction in cat lower esophageal Journal of Neuropathology and Experimental Neurology sphincter (LES). –Poster presentation I Cellular and Molecular Life Sciences NK2 receptors mediate spontaneous contrac- I Hepatology tions of human sigmoid circular smooth muscle I Molecular Psychiatry –Poster presentation Senior Associate Editor: HCl-induced PAF and IL-6 in a cat invitro model I Journal of Alzheimer’s Disease of acute esophagitis. –oral presentation Fadlallah Habr, M.D. HCl-induced IL-6 and H2O2 in cat LES in an in I Brown University - Dean’s Teaching Excellence vitro model of experimental esophagitis. –Poster Award - 2004 presentation I Brown University – Gastroenterology Fellows I American Gastroenterological Association – Outstanding Teacher Award 2004 Chicago, IL – May, 2005 Cyclic AMP response element binding (CREB) Karen Harnett, Ph.D protein is responsible for acid-induced expression Reviewer: of NADPH oxidase NOX5 (short) In Barrett’s I American Journal of Physiology adenocarcinoma cells. –oral presentation I Journal of Pharmacology and Experimental Therapeutics Mucosal production of interleukin (IL)-1beta I Journal of Biochemical Pharmacology and hydrogen peroxide (H2O2) affects sigmoid Presentations: smooth muscle contraction in ulcerative colitis I Guest Lecturer, Boston University Scholl of (UC) – Poster presentation Medicine, September 2002, 2003, 2004. NADPH oxidases contribute to hydrogen peroxide I American Gastroenterological Association – New (H2O2) production by sigmoid smooth muscle in Orleans, LA - 2004 ulcerative colitis (UC) – Poster presentation HCl-induced IL-6 and H2O2 in Cat LES in an NADPH oxidase NOX5 contributes to increased in vitro Model of Experimental Esophagitis proliferation and decreased apoptosis in Barrett’s HCL-induced PAF and IL-6 in a Cat Model of adenocarcinoma cells. – Poster presentation Acute Esophagitis Interleukin-1beta (IL-1beta)-induced production of Rho Kinase mediates Thromboxane A2 (TXA2)- H2O2 and PGE2 in cat lower esophageal sphincter Induced Sustained Contraction in Cat Lower (LES) circular muscle. – Poster presentation Esophageal Sphincter (LES) Rho kinase and human lower esophageal sphincter I American Gastroenterological Association – (LES) tone. – Poster presentation Chicago, Illinois - 2005 HCl-Induced and taurodeoxycholic acid (TDCA) Platelet Activating Factor Affects Esophageal -induced inflammatory mediators in an in vitro Circular Smooth Muscle Contraction In A model of acute esophagitis in the cat. – Poster Human In Vitro Model Of Acute Esophagitis presentation 35 gastroenterology

HCl-induced and taurodeoxycholic acid- Steven Moss, M.D. induced inflammatory mediators in an in vitro Reviewer: model of acute esophagitis in the cat I Gastroenterology Rho Kinase And Human Lower Esophageal I Gut Sphincter Tone I American Journal of Gastroenterology Sripathi Kethu, M.D. I Abstract Review Chair H. pylori pathogenesis sub- Reviewer: section (2003,4) – A.G.A. I Journal of Clinical Outcomes Management Invited Presentations: Invited Presentations: I Frontiers in Cancer Prevention Research (Amer I Endoscopic findings and therapeutic implications in Assoc Cancer Res) – Phoenix, AZ – 2003 patients who develop upper gastrointestinal bleed- Helicobacter, apoptosis and the prevention of ing while hospitalized: a different beast. Presented at gastric cancer the American Society for Gastrointestinal I 38th Jose Teehankee Memorial Lecture, Filipino- Endoscopy Seventh Annual Young Investigator’s Chinese Medical Society - Manila, the Philippines - Conference in Digestive Diseases – Indian Wells, CA 2005 I American Gastroenterological Association – Helicobacter pylori and gastric cancer Orlando, FL - 2003 Presentations: Are we performing unnecessary endoscopies for I American Gastroenterology Association - Chicago, suspected upper gastrointestinal bleeding in Il 2005 hospitalized patients? (Poster of Distinction) p27kip1 deficiency does not increase susceptibility Ji-Su Li, M.D., Ph.D to T cell-mediated Con A-induced liver damage. Reviewer: Expression of claudin 1 and claudin 4 in gastric I Laboratory Investigation adenocarcinomas Invited Presentations: p27kip1 deficiency confers susceptibility to gastric I Tenth International Meeting on Hepatitis C and carcinogenesis in Helicobacter pylori infected mice. Related Viruses – Kyoto, Japan - 2003 Transcriptional upregulation of oncogenic and Kittichai Promrat, M.D. growth related genes by hepatitis C virus core Reviewer: I protein: correlation with cellular proliferation Hepatology and cell cycle progression I Gastroenterology I The Molecular Biology of HBV Viruses – Bergamo, I Journal of Infectious Disease Italy - 2003 I Journal of Medical Virology SiRNA and proteomic analysis of virus-cell I Cochrane Hepato-Biliary Group. interaction involved in hepadnaviral entry. Presentations: I Eleventh International Meeting on HCV and I American Diabetes Association Meeting – 2003 Related Viruses – Germany - 2004 Changes in insulin sensitivity and improvements Upregulation of wnt-2/WISP signaling pathway in liver histology in patients with nonalcoholic by HCV core protein Transcriptional activation steatohepatitis (NASH) treated with pioglitazone of hepatocyte growth factor by HCV I American Association for the Study of Liver I The Molecular Biology of HBV – Woods Hole, Diseases – Orlando, FL - 2003 Massachusetts - 2004 Biochemical relapse and continued weight gain Productive duck hepatitis B virus replication in after discontinuation of pioglitazone as therapy Muscovy duck hepatocytes mediated through of non-alcoholic steatohepatitis (NASH) the recombinant adenovirus infection One year therapy with pioglitazone is associated Inhibition of HBV virus secretion by mutated with histologic improvement in Nonalcoholic small envelope protein and its reversal by a steatohepatitis (NASH) novel glycosylation site 36 brown medical school department of medicine

I American Association for the Study of Liver Presentations: Diseases – New Orleans, LA - 2004 I Speaker – Rockefeller University, New York, NY Changes in serum adiponectin, leptin and January 2004 cytokine levels during pioglitazone therapy for Molecular Pathogenesis of hepatocellular carcinoma non-alcoholic steatohepatitis (NASH)-relationship (HCC) to histological improvement I Speaker – Shanghai International Liver Congress, I American Gastroenterological Association – Hong Kong, February 2004 Chicago, IL - 2005 Molecular pathogenesis of hepatocellular carcinoma Durability of histological and biochemical I Speaker - N.I.H. HCC: screening, diagnosis and improvement after stopping pioglitazone thera- management, April 2004 py for nonalcoholic steatohepatitis (NASH). Is Gene Therapy of HCC Long-Term Therapy Needed? I Co-Moderator – American Assoc. for the Study of Harlan Rich, M.D. Liver Diseases, Boston, MA, November 2004 I Dean’s Teaching Excellence Award – Bio 282, Brown Treatment of HBV: mutants, resistance and viral Medical School2004 kinetics I MD Hooder, 30th Medical Convocation – Brown I Plenary Speaker – Workshop Society for Leukocyte Medical School 2004 Biology, Toronto, Canada, October 2004 I Dean’s Teaching Excellence Award – Bio 351, Brown Effects of ethanol on immune response to HCV virus Medical School2005 I Speaker – Univ Massachusetts Medical Center, Jack R. Wands, M.D. Worcester MA, February 2005 I Jeffrey and Kimberly Greenberg-Artemis and Martha The role of ethanol on the immune response to HCV Joukowsky Professor in Gastroenterology, and I Speaker – 41st Annual Meeting, Japan Society of Professor of Medical Sciences, Brown Medical School Hepatology, Osaka, Japan, June 2005 I Bristol-Myer Squibb Research Award in Infectious “Molecular pathogenesis of hepatocellular carcinoma Diseases, Brown Medical School I Master of Arts, ad eundem, Brown Medical School RESEARCH AND OTHER Editorial Boards: SCHOLARLY ACTIVITIES I International Journal of Oncology

I Cancer Therapy FACULTY MEMBERS OF STUDY SECTIONS AND Editorial Consultant: ADVISORY COMMITTEES I Journal of Clinical Investigation Gyorgy Baffy, M.D. I New England Journal of Medicine I National Institutes of Health, NIDDK - Special I Journal of Biological Chemistry Emphasis Group 2004 I PNAS Piero Biancani, Ph.D I Journal of Infectious Diseases I Merit Review Subcommittee For Gastroenterology, I Gastroenterology Medical Research Service, Veterans Health I Journal of Virology Administration, 2002- 05 I Virology Suzanne de la Monte, M.D. I Nature Medicine I NAL NIH Study Section Member 2003 – 07 I Journal of Medical Virology I Lifespan IACUC Committee Member I Journal of Hepatology JiSu Li, M.D., Ph.D I NIH NIAID Grant Review Committee, Hepatitis C Cooperative Research Center 2005

37 gastroenterology

Steven Moss, M.D. I Biomed 211 - Physiological Pharmacology, I NIH Study Section: NCI R03 Small grants program Pharmakokinetics, Drug and Gene Delivery for cancer epidemiology and prevention – 2004 Pharmacokinetics I Biomed 282 – Brown University - Gastrointestinal Kittichai Promrat, M.D. Motility I Member, Special Emphasis Review Panel Committee, NIDDK, NIH Ancillary Studies to Sripathi Kethu, M.D. Obesity Related Clinical Trials, March 2005 I Biomed 351 – GI Pathophysiology – Small group I Ad Hoc Reviewer, Wellcome Trust Research leader Training Grant I Biomed 343 – Brown U med students in Continuity Clinic RIH Jack R. Wands, M.D. I Chair, NIAID Special Emphasis Panel – HCV pro- JiSu Li, M.D., Ph.D posals, 2005 I Biomed 284 – Graduate Program in Pathobiology - Course Leader TEACHING ACTIVITIES Harlan Rich, M.D. I Biomed 351 – Integrated Gastrointestinal Gyorgy Baffy, M.D. Pathophysiology and Pharmacology 2004 – present I Biomed 282 –Brown U. - Gastroenterology and I Biomed 282 – Gastrointestinal and Liver Hepatology 2003, 2004, 2005 Pathophysiology 1997 – present; Section Leader I PA514.0 – Harvard Medical School – Advanced I Biomed 343 – Longitudinal Ambulatory Clerkship Biomedical Science Nov. 2003 in GI 2003 – present Suzanne de la Monte, M.D. I Biomed 301 – Core Clerkship in Internal Medicine, I Bio 283 Brown U – Molecular Pathogenesis of RIH Preceptor 2003 – present Important World-wide Diseases – Course Director I Core Clerkship in Internal Medicine, VAMC Coordinator, 2003 – present+ Fadlallah Habr, M.D. I Biomed 282 – Brown U – Gastroenterology and I Biomed 373 – Physical Diagnosis 2003 – present Hepatology – Small Group Leader Jack R. Wands, M.D. Karen Harnett, Ph.D I Biomed 305A– Gastroenterology Elective I Biomed 273 - Organ System Pharmacology, I Biomed 282 – Brown University – Gastrointestinal Pharmacokinetics and Liver Pathophysiology I Biomed 273 - Organ System Pharmacology, I BioMed 351 – Brown University – Gastrointestinal Drugs Pathophysiology/Pharmacology I Biomed 126 - Pharmakokinetics I HST120 - Harvard Medical School

38 brown medical school department of medicine

GASTROENTEROLOGY FELLOWSHIP PROGRAM Departed Fellows Edward Pensa, M.D. University Gastroenterology, Providence, RI William Chen, M.D. University Gastroenterology, Providence, RI Eric Berthiaume, M.D. University Gastroenterology, Providence, RI Waymon Lattimore, M.D. Clinical Private Practice, Colorado Henry Damon, M.D. Clinical Private Practice, Connecticut Current Fellows

Name Medical School Residency Program Costica Aloman, M.D. PGY6 Carol Davila U Med(Budapest) U Iowa Hospitals/Clinics Colleen Kelly, M.D. PGY6 Ohio State University Boston Medical Center Patrick Hyatt, M.D. PGY6 Temple University Brown Medical Sch Program in Medicine Carol Mallette, M.D. PGY6 Texas A & M Brown Medical Sch Program in Medicine Chad Morse, M.D. PGY5 Oregon Hlth Sci Univ. Arizona Hlth Sci Unit Kenneth Shieh, M.D. PGY5 Columbia University Barnes-Jewish Hosp, St. Louis, MO Bret Ancowitz, M.D. PGY5 Mount Sinai (NY) Mayo Graduate School of Medicine Deepak Agrawal, M.D. PGY4 Hartmann College (India) Case Western Reserve Mark Branda, M.D. PGY4 U Vermont Yale-New Haven Hospitals Sumona Saha, M.D. PGY4 Dartmouth College Beth Israel-Deaconess Med Ctr Randall Pellish, M.D. PGY4 U Massachusetts Brown Medical School Program in Med

SELECTED PUBLICATIONS I Guarino M, Xiao ZL, Biancani P, Behar J. PAF-like lipids and PAF-induced gallbladder muscle contrac- Gyorgy Baffy, M.D. tion is mediated by different pathways in guinea I Horimoto M, Fulop P, Derdak Z, Wands JR, Baffy pigs. Am J Physiol 2003:285:G1189-97. G. Uncoupling protein-2 deficiency promotes oxi- I Xiao ZL, Biancani P, Behar J. Role of PGE2 on gall- dant stress and delays liver regeneration in mice. bladder muscle cytoprotection of guinea pigs. Am J Hepatology 2004;39:386-92. Physiol 2004;286:G82-8. I Horimoto M, Resnick MB, Konkin TA, Routhier J, I Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, Wands JR, Baffy G. Expression of uncoupling pro- Harnett KM. Pro-inflammatory cytokines alter/reduce tein-2 in human colon cancer. Clin Cancer Res esophageal circular muscle contraction in experimen- 2004;10:6203-7. tal cat esophagitis. Am J Physiol 2004;287:G1131-9. I Baffy G. Uncoupling protein-2 and non-alcoholic Piero Biancani, Ph.D fatty liver disease. Front Biosci 2005;10:2082-96. I Cheng L, Cao W, Behar J, Biancani P and Harnett Jose Behar, M.D. KM. Inflammation induced changes in arachidonic I Xiao ZL, Biancani P, Carey MC, Behar J. acid metabolism in cat les circular muscle. Am J Hydrophilic but not hydrophobic bile acids prevent Physiol Gastrointest Liver Physiol. 2005;288:G787-97. gallbladder muscle dysfunction in acute cholecysti- I Xiao ZL, Amaral J, Biancani P, Behar J.Impaired tis. Hepatology 2003;37:1442-50. cytoprotective function of muscle in human gall- I Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, bladders with cholesterol stones.Am J Physiol Harnett KM. MAPK mediates PKC-dependent con- Gastrointest Liver Physiol. 2005;28:G525-32. traction of cat esophageal and lower esophageal I Cheng L, Cao W, Behar J, Biancani P, Harnett KM. sphincter circular smooth muscle. Am J Physiol Inflammation induced changes in arachidonic acid 2003;285:G86-95. metabolism in cat LES circular muscle.Am J Physiol Gastrointest Liver Physiol. 2005;288:G787-97. 39 gastroenterology

I Harnett KM, Cao W, Biancani P. Signal-transduction I de la Monte S, Wands J. Review of insulin and pathways that regulate smooth muscle function I. insulin-like growth factor expression, signaling and Signal transduction in phasic (esophageal) and tonic malfunction in the central nervous system: relevance (gastroesophageal sphincter) smooth muscles. Am J to Alzheimer’s disease. J Alzheimers Dis 2005;7:45-62. Physiol Gastrointest Liver Physiol. 2005;288:G407-16. I Steen EJ, Terry BJ, Rivera EJ, Cannon J, Neely TR, I Xiao ZL, Pricolo V, Biancani P, Behar J. Role of Tavares R, de la Monte S. Impaired insulin and progesterone signaling in the regulation of G- insulin-like growth factor expression and signaling protein levels in female chronic constipation. mechanisms in Alzheimer’s disease…is this Type 3 Gastroenterology. 2005;128:667-75. diabetes? J Alzheimers Dis 2005;7:63-80.

Weibiao Cao, M.D. Karen Harnett, Ph.D I Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, and I Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, and KM Harnett. Proinflammatory cytokines Harnett KM. Proinflammatory cytokines alter/reduce alter/reduce esophageal circular muscle contraction esophageal circular muscle contraction in experimen- in experimental cat esophagitis. Am J Physiol tal cat esophagitis. Am J Physiol 2004; 287: G1131-1139 Gastrointest Liver Physiol. 2004 Dec;287(6):G1131-9. I Cao W, Vrees MD, Potenti FM, Harnett KM, Fiocchi I Cao W, Harnett KM, Cheng L, Kirber M, Behar J, C, Pricolo V. Interleukin 1beta-induced production and P. Biancani. H2O2, a mediator of esophagitis- of H2O2 contributes to reduced sigmoid colonic induced damage to calcium-release mechanisms in circular smooth muscle contractility in ulcerative cat lower esophageal sphincter (LES). Am J Physiol colitis. J Pharmacol Exp Ther 2004;311: 60-70 Gastrointest Liver Physiol. 2005 in press. I Kim Nayoung, Cao Weibiao, Song In Sung, Kim I Kim N, Cao W, Song IS, Kim CY, Harnett KM, Chung Yong, Harnett Karen M, Cheng Ling, Walsh Cheng L, Walsh MP, and P Biancani. Distinct kinas- Michael P, Biancani P. Distinct Kinases Are Involved es are involved in contraction of cat esophageal and In Contraction Of Cat Esophageal And Lower lower esophageal sphincter smooth muscles. Am J Esophageal Sphincter Smooth Muscles. Am J Physiol Cell Physiol. 2004;287(2):C384-94. Physiol 2004;287: C384-394 I Cheng L, Cao W, Behar J, Biancani P, and KM Harnett. I Harnett KM, Cao W, Biancani P. Signal-transduc- Inflammation induced changes in arachidonic acid tion pathways that regulate smooth muscle func- metabolism in cat les circular muscle. Am J Physiol tion I. Signal transduction in phasic (esophageal) Gastrointest Liver Physiol. 2005; 288(4):G787-97. and tonic (gastroesophageal sphincter) smooth I Harnett KM, Cao W, and P. Biancani. Signal-trans- muscles. Am J Physiol 2005;288:G407-416 duction pathways that regulate smooth muscle I Cheng L, Cao W, Behar J, Biancani P, Harnett KM. function I. Signal transduction in phasic Inflammatory changes in arachidonic acid metabo- (esophageal) and tonic (gastroesophageal sphinc- lism in cat LES circular muscle. Am J Physiol ter) smooth muscles. Am J Physiol Gastrointest Liver 2005;288: G787-797 Physiol. 2005; 288(3): G407-16. Sripathi Kethu, M.D. Suzanne de la Monte, M.D. Kethu S, Rich HR. Bleeding colonic diverticulum. N I Yeon JE, Califano S, Xu J, Wands JR, de la Monte Engl J Med 2003;249:2423. SM. Potential role of PTEN phosphatase in Kethu SR, Davis GC, Reinert SE, Ramzan UC, Moss ethanol-impaired survival signaling in the liver. SF. Low utility of endoscopy for suspected upper gas- Hepatology 2003;38:703-14. trointestinal bleeding occurring in hospitalized I de la Monte SM, Wands JR. Alzheimer-associated patients. South Med J 2005;98:170-5. neuronal thread protein mediated cell death is linked to impaired insulin signaling. J Alzheimers Miran Kim, Ph.D I Dis 2004;6:231-42. Jiang LH, Kim M, Spelta V, Bo X, Surprenant A, North RA. Subunit arrangement in P2X receptors J I Merle P, de la Monte S, Kim M, Herrmann M, Neurosc 2003;26:8903-10. Tanaka S, von dem Bussche A et al. Functional con- sequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology 40 2004;127:1110-22. brown medical school department of medicine

I Adinolfi E, Kim M, Spelta V, DiVirgilio F, I Levine A, Shevah O, Shabat-Sehayek V,Aeed H, Boaz Surprenant A, Tyrosine phosphorylation of Hsp90 M, Moss SF, Niv Y, Avni Y, Shirin H. Masking of 13C within the P2X7 receptor complex negatively regu- urea breath test by proton pump inhibitors is depend- lates P2X7 receptors. J Biol Chem 2003; 278:37344-51. ent on type of medication: comparison between I Merle P, de la Monte S, Herrmann M, Tanaka S, Kim omeprazole, pantoprazole, lansoprazole and esomepra- M, Trepo C, Wands JR. Functional consequences of zole. Aliment Pharmacol Ther 2004;20:117-22. frizzled-7 receptor over-expression in human hepa- I Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, tocellular carcinoma. Hepatology 2003;38:564A. Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, I Merle P, de la Monte S, Kim M, Herrmann M, Moss SF, Hacker A, Wang Y, Casero RA, Wilson KT. Tanaka S, von den Bussche A, Kew MC, Trepo C, Spermine oxidation induced by H pylori results in Wands JR. Functional consequences of Frizzled-7 apoptosis and DNA damage: implications for gastric receptor over-expression in human hepatocellular carcinogenesis. Cancer Res 2004;64:8521-5. carcinoma. Gastroenterology 2004;127:1110-22. I Moss SF, Blaser MJ. Mechanisms of Disease: inflammation and the origins of cancer. Nature JiSu Li, M.D., Ph.D Clinical Practice Oncology 2005;2:90-7. I Ahn SH, Kramvis A, Kawai S, Spangenberg H, Li JS, I Resnick MB, Gavilanez M, Newton E, Konkin T, Kimbi G, Kew M, Wands J, Tong SP. Sequence varia- Bhattacharya B, Britt DE, Sabo E, Moss SF. Claudin tion upstream of precore translation initiation codon expression in gastric adenocarcinomas: a tissue reduces hepatitis B virus e antigen production. microarray study with prognostic correlation. Hum Gastroenterology 2003;125:1370-8. Pathol 2005;36:886-92. I Li JS, Tong SP, Lee HB, Perdigoto A, Wands J. Glycine decarboxylase mediates a postbinding step Kittichai Promrat, M.D. in the life cycle of the avian hepatitis B virus. J Virol I Promrat K, Lutchman G, Uwaifo GI , Freedman RJ , 2004;78:1873-81. Soza A, Heller T, Doo E, Ghany M, Premkumar A, I Khan N, Guarnieri M, Ahn SH, Li JS, Zhou Y, Bang Park Y, Liang TJ, Yanovski JA, Kleiner DE, Hoofnagle G, Kim KH, Wands JR, Tong SP. Modulation of JH. A pilot study of pioglitazone treatment for nonal- hepatitis B virus secretion by naturally occurring coholic steatohepatitis. Hepatology 2004;39:188-196. mutations in the S gene. J Virol 2004;78:3262-70. I Promrat K, Liang TJ. Chemokine systems and hep- I Bang G, Kim KK, Guarnieri M, Zoulim F, Kawai S, atitis C virus infection: is truth in the genes of the Li JS, Wands JR, Tong SP. Effect of mutating the beholders? Hepatology 2003;38:1359-62. two cysteines required for Hbe antigenicity on hep- I Comanor L, Elkin C, Leung K, Krajden M, Kronquist atitis B virus DNA replication and virion secretion. K, Nicolas K, Horansky E, deMedina M, Promrat K, Virology 2005;332:216-24. Sablon E, Ziermann R, Sherlock C. Successful HCV I Fukutomi T, Zhou Y, Kawai S, Eguche H, Wands JR, genotyping of previously failed and low viral load spec- Li JS. Hepatitis C virus core protein stimulates hepa- imens using an HCV RNA qualitative assay based on tocyte growth: correlation with upregulation of transcription-mediated amplification in conjunction wnt-1 expression. Hepatology 2005;41:1096-1105. with the line probe assay. J Clin Virol 2003;28:14-26. I Hoofnagle JH, Ghany MG, Kleiner DE, Doo E, Heller Steven Moss, M.D. T, Promrat K, Ong J, Khokhar F, Soza A, Herion D, I Eguchi H, Herschenhous N, Kuzushita N, Moss SF. Park Y, Everhart JE, Liang TJ. Maintenance therapy H pylori increases proteasome-mediated degrada- with ribavirin in patients with chronic hepatitis C who tion of p27kip1 in gastric epithelial cells. Cancer Res fail to respond to combination therapy with interferon 2003;63:4739-46. alfa and ribavirin. Hepatology 2003;38:66-74. I Shirin H, Sadan O, Shevah O, Bruck R, Boaz M, I Promrat K, McDermott DH, Gonzalez C, Kleiner Moss SF, Everon S, Glezerman M, Avni Y. Positive DE, Koziol DE, Lessie M, Merrrell M, Soza A, serology for H. pylori and vomiting in pregnancy. Ghany MG, Park Y, Alter HJ, Hoofnagle JH, Arch Gynecol Obstet 2004;270-10-14. Murphy PM, Liang TJ. Associations of Chemokine I Eguchi H, Carpentier S, Kim SS, Moss SF. P27 kip1 System Polymorphisms With Clinical Outcomes regulates the apoptotic response of gastric epithelial and Treatment Responses of Chronic Hepatitis C. cells to H. pylori. Gut 2004;53:797-804. Gastroenterology 2003; 124:352-360. 41 gastroenterology

Jack R. Wands, M.D. I Merle P, de la Monte S, Kim M, Herrmann M, I Li J, Tong S, Lee HB, Perdigoto AL, Spangenberg Tanaka S, von Dem Bussche A, Kew MC, Trepo C, HC, Wands JR. Glycine decarboxylase mediates a Wands JR. Functional consequences of frizzled-7 postbinding step in duck hepatitis B virus infection. receptor overexpression in human hepatocellular J Virol 2004;78:1873-81. carcinoma. Gastroenterology 2004;127:1110-22. I Yoon SK, Lim NK, Ha SA, Park YG, Choi JU, Chung I Mohr L, Yeung A, Aloman C, Wittrup D, Wands JR. KW, Sun HS, Choi MJ, Chung J, Wands JR, Kim Antibody-directed therapy for human hepatocellular JW. The human cervical cancer oncogene protein is carcinoma. Gastroenterology 2004;127(5 Suppl a biomarker for human hepatocellular carcinoma. 2):S225-31. Cancer Res 2004:65:5434-41. Listings are limited to the 5 most recent publications per I Wands JR. Prevention of hepatocellular carcinoma. faculty member. N Engl J Med 2004;351:1567-70.

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $3,000,530 $1,304,679 $4,305,209 for Gastroenterology Academic Year 2004 $2,844,854 $1,237,306 $4,082,160

Total Clinical Research Expenses Academic Year 2003 $0 $0 $0 for Gastroenterology Academic Year 2004 $43,516 $5,019 $48,535

BASIC RESEARCH I COBRE - Transduction in Acid Induced Progression of Barrett’s Esophagus (BE) from Metaplasia to György Baffy, M.D. Dysplasia. National Center for Research Resources I UCP2 in the Pathogenesis of Steatohepatitis. National Suzanne de la Monte, M.D. Institute of Diabetes and Digestive and Kidney I Effects of Ethanol on Insulin Signaling in the Brain. I COBRE - The Role of Mitochondrial Uncoupling National Institute on Alcohol Abuse and Alcoholism Protein-2 (UCP2) in Colon Carcinogenesis. National Center for Research Resources Miran Kim, Ph.D. I Wnt Signaling in HCC, NIH/COBRE Jose Behar, M.D. I Myogenic Disorders of the Gallbladder. National Ji-Su Li, M.D. Institute of Diabetes and Digestive and Kidney I Hepatitis C Virus Core Protein and Cell Proliferation. NIDDK I Role of Progesterone in Colonic Muscle Dysfunction. National Institute of Diabetes and I Molecular Target(s) for Interruption of HBV Digestive and Kidney Infection. National Cancer Institute

Piero Biancani, Ph.D. Steven Moss, M.D. I Biophysical Principles of Peristaltic Phenomena. I COBRE - H. Pylori in Gastric Carcinogenesis. National Institute of Diabetes and Digestive and Kidney National Center for Research Resources I H Pylori Vaccine. SBIR Weibiao Cao, Ph.D. I Barrett’s Esophagus DK073327-01. National Institute of Diabetes and Digestive and Kidney

42 brown medical school department of medicine

Kittichai Promrat, M.D. CLINICAL RESEARCH I Weight Management in Nonalcoholic Steatohepatitis (NASH). National Institute of Kittchai Promrat, M.D. Diabetes and Digestive and Kidney I Weight Management in Nonalcoholic Steatohepatitis (NASH). National Institutes of Health Shuping Tong, M.D., Ph.D. I Hepatitis B Virus Replication and Secretion. ACS

Jack Wands, M.D. I Alcohol Effects on the Liver. National Institute on Alcohol Abuse and Alcoholism I Research Training Program in Gastroenterology. National Institute of Diabetes and Digestive and Kidney I Ethanol, IRS-1 Signaling and Neuronal Migration. National Institute on Alcohol Abuse and Alcoholism I Pathogenesis, Immunodiagnosis and Therapy of HCC. NCI Cancer Institute I HBV/HCV in Alcoholics. National Institute on Alcohol Abuse and Alcoholism

Zuo-Liang Xiao, M.D. I Effects and Mechanisms of Actions of Progesterone (PG) on Human Colonic Muscle Function. Lifespan

43 general internal medicine

GENERAL INTERNAL MEDICINE OVERVIEW

he 2003-2005 academic years have seen growth, achievement and change for the Division of TGeneral Internal Medicine (DGIM). Led by Director Michele G. Cyr, MD, FACP, Professor of Medicine, Associate Dean for Graduate Medical Education, and Associate Dean for the Office of Women in Medicine, the Division continues to sponsor a wide array of educational, patient care and research activities. Due to the constraints of space, this report will highlight but a few. The DGIM faculty includes 33 Full Time Faculty, 18 University Medicine Foundation Primary Care Clinical Faculty and 119 Clinical Faculty. Our faculty maintain thriving clinical practices and serve as administrators, dedicated educators, and successful researchers at 5 of the Brown Medical School’s Affiliated Hospitals in Rhode Island – Rhode Island Hospital, Memorial Hospital of Rhode Island, The Miriam Hospital, Veterans Affairs Medical Center and Women & Infants’ Hospital. Michele G. Cyr, M.D., Professor of Medicine; Director, Division of General Internal Medicine Medical education, a chief aspect of the Division’s mission and purpose, is conducted at the Brown Brown Medical School students play a significant role Affiliated Hospitals and involves the training of 178 in the Division and in the Department of Medicine residents. During this two-year period, 128 interns through their participation in core clerkships and were recruited into the 5 Medicine Residencies. 106 sub-internships guided by Division faculty. Mark residents completed 3 or 4 years of training and have Fagan, M.D. serves as the Medical Clerkship Director gone on to fellowships, chief residencies, clinical prac- for Brown and has been elected President of the tices, and clinician educator positions in a variety of National Organization of Clerkship Directors of settings including community-based practice, hospital- Internal Medicine. Many students choose to work ist practice and public health. Twenty-two preliminary with our faculty on research projects, clinical electives medicine interns completed the 1-year program and or in community-based practices. entered into specialty programs with a firm foundation The Division has established an exchange program in Internal Medicine. One General Internal Medicine with Cabral y Baez Hospital in Santiago, Dominican Fellow completed her program in June 2004. Republic. This elective, under the direction of Mark GIM faculty serve as the attendings for the inpatient Fagan, MD and Joseph Diaz, Md, is available to PGY2 general medicine teaching rotations. They provide and PGY3 residents. bedside rounds, noon conference lectures, feedback, Cabral y Baez is a large, public teaching hospital in and evaluation to the residents and medical students. Santiago, the second largest city in the Dominican Furthermore, nearly 50 General Internal Medicine Republic. The hospital has an Internal Medicine Community Physician Faculty and 30 Sub-Specialty residency training program, and the goal is for our Faculty members served this year as preceptors in our residents to integrate into the system there as much as Community-Based Teaching Program, providing a possible. In this elective, residents work with inpatient second site continuity ambulatory experience for the teams of Cabral residents and faculty, attend teaching 2nd and 3rd Year Residents. Residents generally see conferences, and participate in outpatient clinics at patients at these second sites once per week during Cabral. In addition, residents have the opportunity to non-critical care unit months. work with a community development organization in 44 a poor neighborhood of Santiago and to work in a brown medical school department of medicine

clinic in a rural area about 30 minutes from the hos- Hospital. He researches the impact of depression and pital. The elective offers the opportunity to work in a anxiety on chronic medical illness. His work includes large public hospital in a resource scarce country. HIV, large database analysis of antidepressant prescribing, tuberculosis, dengue, and leptospirosis are common studying depression in the caregivers of HIV patients, diagnoses at Cabral. as well as conducting physician-oriented intervention The DGIM Research Unit, directed by Michael Stein, to improve antidepressant treatment adequacy in MD, welcomed four new faculty researchers to the primary care, and among COPD patients. division; Jennifer S. Rose, Ph.D completed her PhD in Nananda F. Col, MD, MPP, MPH, FACP graduated Experimental Psychology at the University of Rhode from The University of Massachusetts Medical School Island. After her postdoctoral training at Indiana where she later completed residencies in Internal University, she joined the industry at Baxter Medicine and Preventive Medicine and received her Pharmaceutical Solutions. Dr. Rose’s main research MPH. She also received a Masters in Public Policy from interests include longitudinal analysis of cigarettes Harvard’s Kennedy School of Government and com- and marijuana smoking behaviors in young women. pleted her fellowship in Clinical Decision Making, With her methodological expertise, she will serve as Informatics, and Telemedicine at Tufts-New England Statistician to the unit. Her abstract “A latent class Medical Center. Dr. Col is a practicing internist. Her analysis of smoking-related attitudes and behaviors main research interests include developing innovative among young women” was selected as one of six approaches to help patients and clinicians make more plenary session presentations at the 2005 Society of informed medical decisions and to leverage clinician General Internal Medicine, 28th Annual Meeting, in time through the use of computer modeling techniques New Orleans, LA. and interactive decision aids. With a focus on women’s The Research Unit expanded their activities into the health, prevention, and behavior change, her work Providence Veteran’s Affairs Medical Center (VAMC), addresses clinical with the receipt of a Targeted Research Enhancement strategies for preventing breast cancer and osteoporosis Program award from the VA Health Services Research according to personal risks and preferences, developing and Development Service. The “Program to Integrate and measuring the effectiveness of decision support Psychosocial and Health Services” is directed by Peter aids, and using audience segmentation to deliver better Friedmann, MD, and includes DGIM faculty Paul brief behavioral interventions in primary care. Pirraglia, MD, and Mark Schleinitz, MD. Christine Duffy, MD, MPH obtained her medical Finally, General Internal Medicine, the largest division degree at Cornell University Medical College and in the Department of Medicine is pleased and very completed her General Internal Medicine Residency at proud to report on a year of continued progress in Rhode Island Hospital in 2001. She completed a post- pursuit of our goals for excellence in education, clinical doctoral fellowship at the Center for Gerontology and care, research and administration. Health Care Research at Brown University before joining the Division of General Internal Medicine. Dr. FACULTY MEMBERS Duffy also completed her Masters in Public Health at Brown University. Dr. Duffy’s research interests include the health care of cancer survivors. In particular, breast FULL-TIME FACULTY (Hospital or Foundation Based) cancer survivors, examining various aspects of their Michele G. Cyr, M.D., Director, Professor of medical care. Included is health maintenance and Medicine, Rhode Island Hospital, Memorial screening practices among women diagnosed with Hospital of Rhode Island, University Medicine breast cancer, as well as the reproductive counseling Foundation young women receive after a diagnosis of breast cancer. Mel Anderson, M.D., Clinical Assistant Professor, Dr. Duffy continues her collaboration with the Veterans Affairs Medical Center Women’s Health Initiative, examining the relationship Ghada Bourjeily, M.D., Assistant Professor, between alcohol and hormone related cancers. Women & Infants Hospital Paul A. Pirraglia, MD, MPH completed his residency Lynn Bowlby, M.D., Assistant Professor (Clinical), at Rhode Island Hospital and his General Internal Rhode Island Hospital, University Medicine Medicine Fellowship at Massachusetts General Foundation 45 general internal medicine

Amos Charles, M.D., Clinical Assistant Professor, Jack Schwartzwald, M.D., Assistant Professor (Clinical), Veterans Affairs Medical Center Rhode Island Hospital, University Medicine Foundation Sybil Cineas, M.D., Clinical Instructor, Rhode Island ***H. Denman Scott, M.D., Professor, Emeritus, Hospital, University Medicine Foundation Secondary, Memorial Hospital of RI *Jennifer Clarke, M.D., Assistant Professor, Rhode ***Michael Stein, M.D., Professor TST, Rhode Island Island Hospital, University Medicine Foundation Hospital, University Medicine Foundation Nananda Col, M.D., Associate Professor RST, Rhode Michelle A. Stozek, M.D., Assistant Professor (Clinical), Island Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation Robert Crausman, M.D., Associate Professor TST, Dominick Tammaro, M.D., Associate Professor TST, Memorial Hospital of RI Rhode Island Hospital, University Medicine Foundation Joseph Diaz, M.D., Assistant Professor, Iris Tong, M.D., Clinical Assistant Professor, Rhode Memorial Hospital of RI Island Hospital/Women & Infants Hospital Christine Duffy, M.D., M.P.H., Assistant Professor, UNIVERSITY MEDICINE FOUNDATION Primary Care Rhode Island Hospital, University Medicine Foundation Francis X. Basile, M.D., Clinical Assistant Professor, Mark Fagan, M.D., Associate Professor TST, Rhode Rhode Island Hospital, University Medicine Foundation Island Hospital, University Medicine Foundation Douglas Blecker, M.D., Clinical Instructor, Rhode **Michael Felder, D.O., Clinical Assistant Professor, Island Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation Thomas Bledsoe, M.D., Clinical Associate Professor, ***Peter Friedmann, M.D., M.P.H., Associate Rhode Island Hospital, University Medicine Foundation Professor RST, Rhode Island Hospital Stefano Cazzaniga, M.D., Clinical Assistant Professor, Debra S. Herman, Ph.D., Clinical Assistant Professor, Rhode Island Hospital, University Medicine Foundation Rhode Island Hospital Laurie Grauel, M.D., Clinical Instructor, Rhode Island *Lucia Larson, M.D., Associate Professor TST, Hospital, University Medicine Foundation Women & Infants Hospital David Herec, M.D., Clinical Assistant Professor, Rhode Michael Maher, M.D., Assistant Professor (Clinical), Island Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation Jennifer Jeremiah, M.D., Clinical Associate Professor, Kelly McGarry, M.D., Assistant Professor, Rhode Rhode Island Hospital, University Medicine Foundation Island Hospital, University Medicine Foundation Michael Johnson, M.D., Clinical Assistant Professor, Margaret A. Miller, M.D., Assistant Professor, Rhode Island Hospital, University Medicine Foundation Woman & Infants Hospital Warren Licht, M.D., Clinical Assistant Professor, Anne W. Moulton, M.D., Associate Professor TST, Miriam Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation Steven Mallozzi, M.D., Clinical Assistant Professor, Paul A. Pirraglia, M.D., Assistant Professor, Miriam Hospital, University Medicine Foundation Rhode Island Hospital Jennifer L. Maude, M.D., Clinical Instructor, *Raymond Powrie, M.D., Assistant Professor TST, Miriam Hospital, University Medicine Foundation Women & Infants Hospital Louis J. Moran, D.O., Clinical Instructor, Rhode Island Jennifer S. Rose, Ph.D., Assistant Professor (Res.), Hospital, University Medicine Foundation Rhode Island Hospital Sara Nugent, M.D., Clinical Instructor, Rhode Island *Karen Rosene-Montella, M.D., Professor TST, Hospital, University Medicine Foundation Women & Infants Hospital Laura Ofstead, M.D., Clinical Assistant Professor, Rhode Cynthia Rosengard, Ph.D., Assistant Professor (Res.), Island Hospital, University Medicine Foundation Rhode Island Jeanne Oliva, M.D., Clinical Instructor, Rhode Island Benjamin Sapers, M.D., Assistant Professor (Clinical), Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation Edward Stulik, M.D., Clinical Assistant Professor, Rhode Mark Schleinitz, M.D., M.S., Assistant Professor, Island Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation 46 brown medical school department of medicine

James Sullivan, M.D., Clinical Assistant Professor, Pradeep Chopra, M.D., Assistant Professor (Clinical), Miriam Hospital, University Medicine Foundation Rhode Island Hospital Tony Wu, M.D., Clinical Assistant Professor, Rhode Michael Cohen-Uram, M.D., Clinical Instructor, Island Hospital, University Medicine Foundation Veterans Affairs Medical Center * Joint appointment in Ob/Gyn Reid Coleman, M.D., Clinical Associate Professor, **Joint appointment in Peds *** Joint appointment in Community Health Miriam Hospital Joyce Coppola, M.D., Clinical Assistant Professor, VOLUNTEER FACULTY Memorial Hospital of RI Hani Abdallah, M.D., Assistant Professor of Medicine Frederick Crisafulli, M.D., Clinical Associate (Clinical), Memorial Hospital of RI Professor, Miriam Hospital Khaja Ahmed, M.D., CHE, Clinical Assistant Anne Cushing-Brescia, M.D., Clinical Assistant Professor, Veterans Affairs Medical Center Professor, Miriam Hospital Ali Akhtar, M.D., Clinical Instructor, Kwame Dapaah-Afriyie, M.D., Clinical Assistant Memorial Hospital of RI Professor, Miriam Hospital Scott A. Allen, M.D., Clinical Assistant Professor, Allen Dennison, M.D., Clinical Assistant Professor, Miriam Hospital Rhode Island Hospital Ahmad Al-Raqqad, M.D., Clinical Instructor, Hector Derreza, M.D., Clinical Instructor, Memorial Hospital of RI Miriam Hospital Kim Amin, M.D., Clinical Assistant Professor, Jeffrey Drogin, M.D., Clinical Instructor, Memorial Hospital of RI Rhode Island Hospital Rex Appenfeller, M.D., Clinical Assistant Professor, Yul Ejnes, M.D., Clinical Associate Professor, Miriam Hospital Rhode Island Hospital Daniel Asiedu, M.D., Ph.D., Clinical Instructor, Peter M. Eller, M.D., Clinical Assistant Professor, Miriam Hospital Miriam Hospital Jeffrey Austerlitz, M.D., Clinical Assistant Professor, Elaine Fain, M.D., Clinical Instructor, Veterans Affairs Medical Center Miriam Hospital Munawar Azam, M.D., Clinical Instructor, St. Joseph Walid Farah, M.D., Clinical Instructor, Kaku Badoe, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital Bruce E. Fischer, M.D., Clinical Instructor, Kim Basu, M.D., Clinical Instructor, Rhode Island Hospital Rhode Island Hospital Andrea Flory, M.D., Clinical Instructor, Dawna Blake, M.D., Clinical Assistant Professor, Rhode Island Hospital Veterans Affairs Medical Center David Fried, M.D., Clinical Assistant Professor, Sheenagh M. Bodkin, MB, Bch BAO, LRCSI & LRDCPI, Rhode Island Hospital M. Med. Sci (Physiol), Clinical Instructor, Rhode Denise Glickman, M.D., Clinical Assistant Professor, Island Hospital Rhode Island Hospital Bruno Borenstein, M.D., Clinical Assistant Professor, Amy S. Gottlieb, M.D., Assistant Professor (Clinical), Memorial Hospital of RI Women & Infants Hospital Steven Brin, M.D., Clinical Assistant Professor, Walter Goula, M.D., Clinical Instructor, Rhode Island Hospital Miriam Hospital Lucy Burciaga, M.D., Clinical Instructor, Nicholas Grumbach, M.D., Clinical Assistant Rhode Island Hospital Professor, Rhode Island Hospital Frank Capizzo, M.D., M.S., Clinical Assistant Sajeev Handa, M.D., Clinical Instructor, Professor, Rhode Island Hospital Rhode Island Hospital Jayson Carr, M.D., Clinical Instructor, R. Scott Hanson, M.D., M.P.H., Clinical Assistant Kent County Memorial Hospital Professor, Rhode Island Hospital Dana Chofay, M.D., Clinical Instructor, Rhode Island Hospital 47 general internal medicine

Pamela Harrop, M.D., Clinical Assistant Professor, Fadi Mansourati, M.D., Clinical Assistant Professor, Rhode Island Hospital Memorial Hospital of RI Michael Hayden, D.O., Clinical Instructor, Vincent Marcaccio, M.D., Clinical Instructor, Rhode Island Hospital Roger Williams Medical Center Christine Herbert, M.D., Ph.D., Clinical Assistant David Marcoux, M.D., Clinical Assistant Professor, Professor, Miriam Hospital Miriam Hospital Melvin Hershkowitz, M.D., Clinical Assistant Edward Martin, M.D., Clinical Assistant Professor, Professor, Emeritus, Miriam Hospital Roger Williams Medical Center Guang Hu, M.D., Clinical Assistant Professor, Paul Martin, M.D., Clinical Instructor, Veterans Affairs Medical Center Miriam Hospital S. Iftikihar Hussain, M.D., Clinical Instructor, Carla Martin, M.D., Clinical Instructor, Miriam Hospital Memorial Hospital of RI Sadia Iftikhar, M.D., Clinical Assistant Professor, Steven G. McCloy, M.D., Clinical Assistant Professor, Memorial Hospital of RI Miriam Hospital Henry Izeman, M.D., Clinical Associate Professor of Jacqueline Michaud, M.D., Clinical Instructor, Medicine, Emeritus, Miriam Hospital Rhode Island Hospital Mark Jacobs, M.D., Clinical Assistant Professor, John Miskovsky, M.D., Clinical Assistant Professor, Miriam Hospital Memorial Hospital of RI Steven Kempner, M.D., Clinical Assistant Professor, Blas Moreno, M.D., Clinical Assistant Professor, Miriam Hospital Emeritus, Memorial Hospital of RI Sree H. Kesan, M.D., Clinical Assistant Professor, Rossana Moura, M.D., Clinical Instructor, Memorial Hospital of RI Women & Infants Hospital Razib Khaund, M.D., Clinical Assistant Professor, Paul Murphy, M.D., Clinical Assistant Professor, Miriam Hospital Veterans Affairs Medical Center William Kirkpatrick, L.I.C.S.W., Senior Teaching Marwan Mustaklem, M.D., Clinical Instructor, Associate, Miriam Hospital Memorial Hospital of RI David Kitzes, M.D., Clinical Associate Professor, Lina Nemchenok, M.D., Clinical Instructor, Miriam Hospital Rhode Island Hospital Lisa Kleinert, M.D., Clinical Instructor, Veterans Mariola Nowak, M.D., Clinical Instructor, Affairs Medical Center Rhode Island Hospital Chi Kuang Lai, M.D., Clinical Assistant Professor, Gail O’Brien, M.D., Clinical Associate Professor, Veterans Affairs Medical Center Rhode Island Hospital Nancy T. Littell, M.D., M.P.H., Clinical Assistant Michael O’Connell,Jr.,M.D.,Clinical Instructor, Professor, Rhode Island Hospital Veterans Affairs Medical Center Vito Longobardi, M.D., Clinical Instructor, Yogesh Pancholi, M.D., Clinical Instructor, Memorial Hospital of RI Memorial Hospital of RI Edwin Lovering, M.D., Clinical Associate Professor, Joel Park II, M.D., Ph.D., Clinical Instructor, Emeritus, Memorial Hospital of RI Rhode Island Hospital Hua Chung Lu, M.D., Clinical Instructor, Vincent Pera, M.D., Clinical Assistant Professor, Rhode Island Hospital Miriam Hospital Michael Macko, M.D., Clinical Associate Professor, John N. Pliakas, M.D., Clinical Teaching Associate, Roger Williams Medical Center Memorial Hospital of RI Samir Makarious, M.D., Clinical Assistant Professor, Jose Polanco, M.D., Clinical Assistant Professor, Miriam Hospital Memorial Hospital of RI Timothy Manown, M.D., Clinical Instructor, Jose Poleo, M.D., Clinical Instructor, Kent County Memorial Hospital Rhode Island Hospital 48 brown medical school department of medicine

Roy Poses, M.D., Clinical Associate Professor, Lewis R. Weiner, M.D., Clinical Assistant Professor, Memorial Hospital of RI Rhode Island Hospital R. Preston Reynolds, M.D., Clinical Instructor, Jiaying Wen, M.D., Clinical Instructor, Memorial Hospital of RI Memorial Hospital of RI Anthony R. Ricci, M.D., Clinical Instructor, Edward Wheeler, M.D., Clinical Assistant Professor, Kent County Memorial Hospital Rhode Island Hospital Jennifer Roh-Hur, M.D., Assistant Professor (Clinical), Karen L. Woolfall-Quinn, M.D., Clinical Instructor, Rhode Island Hospital Veterans Affairs Medical Center Richard J. Ruggieri, M.D., Clinical Assistant Professor, Hugo M. Yamada, M.D., Clinical Instructor, Miriam Hospital Rhode Island Hospital Larry Schoenfeld, M.D., Clinical Assistant Professor, Madhavi Yerneni, M.D., Clinical Instructor, Miriam Hospital Miriam Hospital Howard Schulman, M.D., Clinical Assistant Professor, Najam Zaidi, M.D., Assistant Professor (Clinical), Miriam Hospital Memorial Hospital of RI Ronald Schwartz, M.D., Clinical Assistant Professor, Memorial Hospital of RI NATIONAL AND INTERNATIONAL Stephen Scott, M.D., Clinical Assistant Professor, HONORS AND RECOGNITION Rhode Island Hospital Steven Sepe, M.D., Ph.D., Clinical Associate Professor, Michele G. Cyr, M.D. Rhode Island Hospital Awards: Russell Settipane, M.D., Clinical Associate Professor, I Rhode Island Medical Women’s Association – Rhode Island Hospital Rhode Island Woman Physician of the Year - 2005 Parviz Shavandy, M.D., Clinical Instructor, I Best Doctors in America’s Best Doctor – Internal Veterans Affairs Medical Center Medicine, 2003-04 Michael S. Siclari, M.D., Clinical Assistant Professor, Invited presentations: Roger Williams Medical Center I Lecturer: What Every Woman Should Know About Diane R. Siedlecki, M.D., Clinical Instructor, Women’s Health. American Association for Miriam Hospital University Women’s National Conference for College Women Student Leaders (NCCWSL) and Jean Smith, M.D., Clinical Instructor, the Convention of the American Association of Miriam Hospital University Women, Providence, RI, June 21, 2003. W. Tyler Smith, Jr., M.D., Clinical Instructor, I Workshop Co-Director: Getting Through the Rhode Island Hospital Match. American College of Physicians’ Annual Lynn Sommerville, M.D., Ph.D., Clinical Assistant Session 2004, New Orleans, April 21, 2004. Professor, Miriam Hospital I Lecturer: Managing Menopause in 2004. American John Stoukides, M.D., Clinical Assistant Professor, College of Physicians Annual Session 2004, New Roger Williams Medical Center Orleans, April 23, 2004. Flora Treger, M.D., Clinical Instructor, I Lecturer: Meet and Eat with the Professor - Rhode Island Hospital MenopauseTutorial. American College of Physicians’ Caroline Troise, M.D., Ph.D., Clinical Assistant Annual Session 2004, New Orleans, April 23, 2004. Professor, Miriam Hospital I Co-presenter: Menopause Reconsidered. Health New Philip Vaidyan, M.D., Clinical Assistant Professor, England Conference. Springfield, MA, May 26, 2004. Miriam Hospital I Co-Panelist: Menopause/Manopause: Managing the Todd Viccione, M.D., Clinical Instructor, Transitions. American College of Physicians’ Rhode Island Hospital Annual Session 2005, San Fransisco, CA, April 15, Barbara Weil, M.D., Clinical Instructor, 2005. Veterans Affairs Medical Center 49 general internal medicine

I Workshop Co-Director: Mastering the Match. I Invited presentation, Strategies for Improving Primary American College of Physicians’ Annual Session Care Practice: Using Patient-Centered Technology to 2005, San Fransisco, CA, April 15, 2005 Leverage Physician Time, The World Health Organization, Geneva, Switzerland. June 17, 2004. Nananda Col, M.D., M.P.P., M.P.H. I Invited presentation: Using Internet Technologies to Invited Presentations: Improve and Simplify Counseling about Menopause. I Calculating Your Patient’s Risk Profile for Coronary The Amsterdam Menopause Symposium, Heart Disease, North American Menopause Society, Amsterdam, the Netherlands. October 4, 2004. Miami Beach, Florida. September 18, 2003. I The Discrepancy between Observational and I Obstetric and Gynecology Grand Rounds, Medical Randomized Trials on HRT, North American Decision Making in the Management of Menopause Society, Miami Beach, Florida. Menopause. Boston University, Boston, MA, September 19, 2003. December 17, 2003. I Short-term Menopausal Hormone Therapy for I Invited presentation, Leadership Panel for Women Symptom Relief: An Updated Decision Model. 25th Faculty: Breaking the Glass Ceiling. Panel discus- Annual Meeting of the Society for Med Decis sion with Drs. Bernadine Healy and Sally Making, 2003, Chicago, Ill. October 20, 2003. Shumaker; discussant: Dr.William Applegate. Wake Forest University Baptist Medical Center, Winston- I Weber G, Col NF. Methods for Extrapolating Risk Salem, North Carolina. October 29, 2003. Equations Beyond Their Valid Intervals. 25th Annual Meeting of the Society for Med Decis I Invited presentation, The 9th Annual Graylyn Making, 2003, Chicago, Ill. October 19, 2003. Conference on Women’s Health; Women’s Cognitive Health, Winston-Salem, North Carolina, I Weber G, Col NF. Enter the matrix: Improved soft- Reconciling Findings of Randomized Clinical Trials ware for modeling the effects of treatments on vs. observational Studies. Did Expectations Shape multiple comorbidities using markov processes. Experience? Panel discussion with Drs. Jacques 25th Annual Meeting of the Society for Med Decis Rossouw and Leon Thal. Winston-Salem, North Making, 2003, Chicago, Ill. October 20, 2003. Carolina. October 31, 2003. Joseph A. Diaz, M.D. I General Medicine Research Conference, Strategies I Reviewer, Human Reproduction, 2003 for Improving Primary Care Practice: Using I Reviewer, International Journal of Medical Patient-Centered Technology to Leverage Physician Informatics, 2003 Time, Beth Israel Deaconess Medical Center, I Boston, MA, February 11, 2004. Reviewer, Annals of Family Medicine, 2004 Awards: I Short term HT for menopausal symptom relief: I Understanding the Trade-offs between Length of Chairman’s Award for Outstanding Teaching, Life and Quality of Life. Wake Forest School of Department of Medicine, Brown Medical School, Medicine, Center of Excellence in Women’s Health. Providence, RI, May 2004 Winston-Salem, NC. February 3, 2004. I Outstanding Volunteer Service Recognition, “Good Health Starts with Good People”,RI Free I Brown Medical School Grand Rounds, Dept of Medicine. Patient-centered Informatics: Enhancing Clinic/BC&BS of RI, Providence, RI, October 2005 Patients’ Role in Decision-Making and Leveraging Invited Presentations: Physicians’ Time. Providence, RI, March 8, 2005. I Grand Rounds Presenter, Department of Medicine, Memorial Hospital of Rhode Island - Morbidity I Invited speaker, NIH State-of-the-Science Conference on Management of Menopause-Related and Mortality Conference, Pawtucket, RI, Symptoms, March 21-23, 2005; Strategies and September 2004 Issues for Managing Menopause-Related Symptoms I Lecture, Internal Medicine Residency Program, in Diverse Populations; The Impact of Risk Status, Hospital Regional Universitario Jose Maria Cabral y Preexisting Morbidity, and Polypharmacy on Baez – Evaluacion y Tratamiento de Pacientes con Treatment Decisions concerning Menopausal Hiperlipidemia, Santiago, Dominican Republic, Symptoms; Bethesda, Maryland, March 22, 2005. October 2004

50 brown medical school department of medicine

I Workshop Facilitator, Doctoring at Brown, Annual Peter D. Friedmann, M.D., MPH Clinical Faculty Development Workshop, Brown Invited Presentations: Medical School – Attending Physician Duties and I Permanent Member, NIH Study Section, Drug Responsibilities on the Teaching Wards, Providence, Abuse Health Services Research (NIDA-F). National RI, November 2004 Institute on Drug Abuse, Rockville, MD. 2004-07. I Speaker, Drexel University College of Medicine – I Invited Speaker, 29th Congress of the International Communication Skills for Male Cancer Screening, Academy of Law and Mental Health. Sorbonne, Philadelphia, PA, December 2004 Paris France. I Lecture, Internal Medicine Residency Program, Carol Landau, PhD Hospital Regional Universitario Jose Maria Cabral y I Editorial Board member, Menopause Management Baez -–Introducion a la Medicina Basada en la Medical Advisory Board, Wellness Council of Evidencia, Santiago, Dominican Republic, February America, Omaha, NB, 2001-present 2005 I Chair, Clinical Appointment and Promotions I Medical Convocation Faculty Speaker, Brown Medical Committee, Brown University Department of School Class of 2005, Providence, RI, May 2005 Psychiatry and Human Behavior Christine Duffy, MD, MPH I Past President, Rhode Island Psychological Invited Presentations: Association I Health Behaviors and Risk Perceptions of Breast Invited Presentations: Cancer Survivors, Society of General Internal I “Current Issues in Women’s Health: Doctor-Patient Medicine National Meeting, New Orleans, LA, 2005. Communications,” Meeting of the American I Oral Abstract Presentation “Alcohol, Folate and Association of University Women, Providence, RI, Breast Cancer in the Women’s Health Initiative” June 2003. Society of General Internal Medicine National Meeting, Chicago, IL, 2004. Kelly A. McGarry, M.D. I Top Doctor for Women, Rhode Island Monthly, 2003 I Oral Abstract Presentation “Alcohol, Folate and Breast Cancer in the Women’s Health Inititative”, Invited Presentations: I Society of General Internal Medicine Regional Panelist - with Michelle G. Cyr, MD and Carol Meeting, Boston, MA, 2004. Landau, PhD. “What Every Woman Should Know About Women’s Health” Sponsored by the National I Oral Abstract Presentation, “National trends in anti- Conference for College Women Student Leaders depressant prescribing in primary care to patients (NCCWSL) and American Association of University with Chronic Obstructive Pulmonary Disease”,2004. Women (AAUW) Providence, RI June 21, 2003 Mark J. Fagan, M.D. I Co-moderator for the Clinical Vignettes Section at I President, National Clerkship Directors in Internal the Regional Society of General Internal Medicine Medicine (CDIM), 2003 Meeting, sponsored by Massachusetts General Invited presentations: Hospital , Boston, MA March 5, 2004 I “Teaching Students and Residents Oral Case I Workshop leader with Michelle G. Cyr, MD and Presentation Skills”.Society of General Internal Dominick Tammaro, MD , “Getting Through the Medicine National Meeting, Chicago, IL, May 2004. Match” American College of Physicians – American I “Is Treating Chronic Pain Torture? A Survey of Society of Internal Medicine 2004 Annual Session. Brown Internal Medicine Residents.” Medical New Orleans, LA, April 23, 2004. Grand Rounds, Rhode Island Hospital, The Miriam I Invited speaker “Osteoporosis” Women’s Health Hospital, VA Medical Center, Newport Hospital, Workshop, sponsored by Griffin Hospital March 8, 2005. Community Center of Excellence, Yale University, I “Teaching and Evaluating Oral Case Presentations”. New Haven, Ct December 14, 2004 Society of General Internal Medicine National Meeting, New Orleans, LA, May 2005.

51 general internal medicine

Anne W. Moulton, M.D. I Rosengard, C., Stein, L. A. R., Colby, S. M., Barnett, Invited Presentations: N. P., Monti, P. M., Golembeske, C., & Lebeau- I Invited speaker “Planning for Your Professional Craven, R. (2005, June). Co-occurring sexual risk Development” Office of Women in Medicine and substance use behavior among incarcerated Professional Development Series: Sponsored by adolescents. Presented at the National HIV Brown Medical School’s Faculty Club, Providence, Prevention Conference. Atlanta, GA. RI, November 2004 I Rosengard, C. (2005, April). Adolescents’ pregnancy intentions: Similarities and Differences Between Paul A. Pirraglia, M.D., M.P.H. Males and Females. Presented to the I National trends in antidepressant prescribing in pri- Community/Policy/Planning Committee, mary care to patients with chronic obstructive pul- Department of Public Health. Providence, RI. monary disease. Oral Presentation at New England Regional Society of General Internal Medicine I Rosengard, C., Phipps, M. G., Adler, N. E., & Ellen, Meeting, Boston, MA, March 5, 2004 and poster pres- J. M. (2005, April). Psychosocial correlates of ado- entation at National Society of General Internal lescent males’ pregnancy intention. Presented at the Medicine Meeting, Chicago, IL, May 13, 2004. Annual Meeting of the Society of Behavioral Medicine. Boston, MA. I Antidepressant treatment adequacy in veterans with chronic obstructive pulmonary disease. Poster I Rosengard, C., Adler, N. E., Gurvey, J. E., & Ellen, J. presentation at Complexities of Co-Occurring M. (2005, March). Adolescent partner type experi- Conditions, Washington DC, June 24, 2004. ence: Psychosocial and behavioral differences. Presented at the Annual Meeting of the Society of I Caregiving is associated with depressive symptom Adolescent Medicine. Los Angeles, CA. burden among the significant others of HIV-infect- ed individuals. Oral and poster presentation at I Rosengard, C., Danklefs, S. E., & Frye, B. (2004, July). NIMH Annual International Research Conference Family factors associated with adolescents’ sexual on the Role of Families in Preventing and Adapting risk behaviors in different racial/ethnic groups. to HIV/AIDS, Atlanta, GA, July 22, 2004. Presented at the NIMH Annual International Research Conference on the Role of Families in I Research Career Development award from the Preventing and Adapting to HIV/AIDS. Atlanta, GA. VAMC, 2005 I Rosengard, C., Phipps, M.G., Adler, N. E., & Ellen, J. Susan E. Ramsey, Ph.D. M. (2004, March). Adolescent pregnancy intentions Invited Presentations: and pregnancy outcomes: A longitudinal examina- I Grand Rounds Presentation. Motivating for tion. Presented at the biennial meeting of the Society Lifestyle Changes. St. Luke’s Hospital, New Bedford, for Research on Adolescence. Baltimore, MD. Massachusetts, October 2003. Mark D. Schleinitz, M.D., MSc Jennifer S. Rose, Ph.D. I Milton W. Hamolsky Junior Faculty Award for the I Rose JS, Chassin L, Presson CC, Sherman SJ, Stein most outstanding scientific presentation, Society of MD, Col NF.“A latent class analysis of smoking- General Internal Medicine, 26th Annual Meeting, related attitudes and behaviors among young Vancouver, BC, May 2003. women”.Society of General Internal Medicine, 28th I Symposium Chair, Society for Medical Decision Annual Meeting, New Orleans, LA, May 11-14, 2005 Making, 27th Annual Meeting, San Francisco, CA, Cynthia Rosengard, Ph.D., MPH October 2005. I Rosengard, C., Stein, L. A. R., Colby, S. M., Barnett, N. Invited Presentations: P., Monti, P. M., Golembeske, C., Lebeau-Craven, R., I “Should We Study Ultrasound for Breast Cancer & Miranda, R. (2005, June). Randomized control trial Screening: a Value of Information Analysis,” Society of motivational enhancement of substance use treat- of General Internal Medicine 27th Annual Meeting; ment among incarcerated adolescents: Reductions in Chicago, IL; May 2004. sexual HIV risk behaviors. Presented at the National I “The Effect of Medicaid Bed-Hold Policies on HIV Prevention Conference. Atlanta, GA. Hospital Length of Stay,” Association of Health Services Research / Academy Health Annual Meeting; San Diego, CA; June 2004. 52 brown medical school department of medicine

I “Implement or Analyze? A Value of Information I Journal of General Internal Medicine, Peer Analysis of Ultrasound for Breast Cancer Reviewer, 1991 to present Screening,” Society for Medical Decision Making I Annals of Internal Medicine, Peer Reviewer, 2001 to 26th Annual Meeting, Atlanta, GA;October 2004. present I “Association of Socio-Demographic Factors with Invited presentations: Utilities for Breast Cancer: Implications for I Interviewing for Residency Programs, ACP Disparity,” Society of General Internal Medicine American College of Physicians, Annual Session, 28th Annual Meeting; New Orleans, LA; May 2005. New Orleans, LA, Co-Presenter, April 2004 I “So You Want to be a Fish? Starting a Career in I Morning Report: Fourteen Simultaneous Sessions, Cardiovascular Outcomes Research,” American Association of Program Directors in Internal Heart Association, 6th Scientific Forum on Quality Medicine, New Orleans, LA, Overall Workshop of Care and Outcomes Research in Cardiovascular Director/Small Group Facilitator, April 2004 Disease and Stroke; Washington, DC; May 2005. I Morning Report: Fourteen Simultaneous Sessions, I “Association of Socio-Demographic Factors with Association of Program Directors in Internal Utilities for Breast Cancer: Implications for Medicine, San Francisco, CA, Overall Workshop Disparity,” New England Regional Building Director/Small Group Facilitator, April 11, 2005 Interdisciplinary Research Careers in Women’s I Interviewing for Residency Programs, ACP Health Meeting; Providence, RI; May 2005. American College of Physicians, Annual Session, I “Antiplatelet Therapy: Which Drugs for Which San Francisco, CA, Co-Presenter, April 2005 Patients?” Medical Grand Rounds, Rhode Island I “Mastering the Match”,ACP American College of Hospital, The Miriam Hospital, VA Medical Center, Physicians, Annual Sessions, San Francisco, CA, Co- Newport Hospital, March 8, 2005. Presenter, April 15, 2005 Michael D. Stein, M.D. I “Advocating for Residents in the Fellowship I Research Institute on Addictions. “Grim Charity: Application Process”,Association of Program Injection Drug Users and Needle Sharing.” Director’s in Internal Medicine, San Francisco, CA, November 14, 2003 Workshop, April 15, 2005 I St. Ann’s Hospital, “HIV and Depression.” April 6, 2004 I Society of General Internal Medicine, 27th Annual Meeting, “Chronic Disease & Substance Abuse: New Research Initiatives.” May 14, 2004. I Society of General Internal Medicine, 27th Annual Meeting, “Office-based Treatment of Prescription Opioid and Heroin Dependent Patients.” May 14, 2004. I The Miriam Hospital, Morbidity & Mortality Meeting. “A 42-Year Old Woman with HIV/AID Presenting with Shortness of Breath and Anemia”. May 10, 2005

Dominick Tammaro, M.D. I Associate Chief for Clinical Affairs for the Department of Medicine, Rhode Island Hospital, 2003 I Faculty Appreciation Award, Brown Medical School MD Class of 2001 and 2004 I Faculty Marshall, Brown University School of Medicine Commencement, 2004

53 general internal medicine

RESEARCH AND OTHER TEACHING ACTIVITIES SCHOLARLY ACTIVITIES EDUCATION HONORS FACULTY MEMBERS OF STUDY SECTIONS AND Mark J. Fagan, M.D. ADVISORY COMMITTEES I Chosen as Marshal, Brown Medical School, Class of Michele G. Cyr, M.D. 2003 I Co-PI, Women’s Health Initiative Vanguard Center, I Recipient of Profile in Competence Award, Brown Memorial Hospital of Rhode Island of Rhode Medical School, Class of 2004 Island, 2001 – present I Chosen as Hooder, Brown Medical School, Class of I PI, National Cancer Institute of Canada (NCIC), “A 2004 Randomized Study of the Effect of Exemestane vs. I Selected for membership in the Gold Humanism Placebo on Breast Density in Postmenopausal Honor Society (GHHS), 2004 Women at Increased Risk for Development of I Recipient of Teaching Excellence Award, Brown Breast Cancer”,Years: 2003-current. Medical School, Class of 2005 I Leadership Director for the Brown University/ I Brown Medical School nominee for the Alpha Women & Infants Hospital National Center of Omega Alpha Robert J. Glaser Distinguished Excellence in Women’s Health, Department of Teacher Award, May, 2005 Health and Human Services “National Centers of Excellence in Women’s Health”,Years: 2003-2007 Kelly A. McGarry, M.D. I PI, National Cancer Institute of Canada (NCIC), I Best Doctors in America – Internal Medicine, 2003 NCIC CTG Protocol Number: MAP.3,“A Phase III – 2004 Randomized Study of Exemestane Plus Placebo I Gold Humanism Honor Society , Inductee, 2004 Versus Exemestane Plus Celecoxib Versus Placebo in I Strathmore’s Who’s Who – a publication recogniz- Postmenopausal Women at Increased Risk of ing men and women who have achieved success in Developing Breast Cancer”,Years: 2004 – current. their respective fields, 2005 IRobert S. Crausman, M.D. Paul A. Pirraglia, M.D., M.P.H. I Principal Investigator, development of a curriculum I American Psychosomatic Society Physician-Scientist in Podogeriatrics, HRSA Fellowship, 2004. Peter D. Friedmann, M.D., MPH TEACHING RESPONSIBILITIES I Director, “Program to Integrate Psychosocial and Health Services,” Providence VAMC HSR&D Michele Cyr, M.D. Targeted Research Enhancement Program. I Ward Attending - Med B (Inpatient Medical Service) I Lead Investigator, “Step’n Out,” a four state multi- I General Medicine Consult Ward Attending center clinical trial of collaborative behavioral man- I Problem-Based Learning, 3rd Year Medical Clerks agement between parole officers and addiction treatment counselors for drug-involved parolees. I Chief Residents Supervisor as Inpatient Attendings I I Course Director, American Society of Addiction Ambulatory Block Seminars for Internal Medicine Medicine Buprenorphine Trainings, Fall River MA, Residents Cumberland MD, Portland ME, and Chicago, IL. I ACGME Core Competency Retreat, Program I Co-Principal Investigator, Health Resources and Coordinator & Speaker Services Administration, Special Projects of I Brown Medical School Graduate Medical National Significance to integrates HAART and Education Committee buprenorphine treatment for HIV-infected, opiate Jennifer Clarke, M.D., MPH dependent patients. I Second Site Resident Seminars Susan E. Ramsey, Ph.D. I Ambulatory-Block Didactics (Health Care for the I Member, Special Emphasis Panel, National Institute Incarcerated, Senior Research Project Development) on Alcohol Abuse and Alcoholism, 2004. 54 brown medical school department of medicine

Joseph Diaz, M.D. I Primary care and categorical block seminars on I Site Director, Brown Medical School Internal clinical teaching Medicine Clerkship, Memorial Hospital of Rhode I Co-leader weekly intern conference Island I Preceptor for continuity resident I Co-coordinator, 3rd year Medical Student Internal I Medical service attending Medicine OSCE I Preceptor, Memorial Hospital of Rhode Island Carol Landau, PhD Resident Clinic I Director, Behavioral Sciences Curriculum, General Internal Medicine Residency I Evidence-based medicine lecture series for the Memorial Hospital of Rhode Island Residency I Professional Development seminars, General Internal Medicine I Ambulatory-Block Didactics, Rhode Island Hospital, with Carol Landau, the bilingual inter- I Behavioral Medicine seminars, Categorical view and care of the underserved Residency Block I Interim Director, Internal Medicine Residency I Psychological Issues seminars, Medicine-Pediatrics Program, Memorial Hospital of RI/Brown Medical Residency School, Pawtucket, RI, June – September 2004 Michael Maher, M.D. I Co-Coordinator, Dominican Republic Medical I Preceptor, 3rd year Brown Medical School Internal Exchange, Clinical Program, Department of Medicine, Medicine Clerkship Brown Medical School, October 2004 – present I Ward Attending Mark J. Fagan, M.D. I Outpatient Clinical Preceptor I President, National Clerkship Directors in Internal Medicine (CDIM), 2003 Janet Manes, M.D. I Site Director, for the physical diagnosis class I Clerkship Director, Core Clerkship in Medicine, Brown Medical School Kelly A. McGarry, M.D. I Medical school curriculum committee and basic I Sub-internship Coordinator , Brown Medical School clinical skills committee I Dean’s Letter writer for Brown Medical School I Director, Medical Primary Care Unit (MPCU), students which serves as a site for about 10 students/year for I Ward Attending - Med B (Inpatient Medical Service) the required Longitudinal Clerkship I General Medicine Consult Ward Attending I Preceptor, Medical Students conducting independ- I Chief Residents Supervisor as Inpatient Attendings ent study projects I Ambulatory Block Seminars for Internal Medicine I Ward Attending - Med B (Inpatient Medical Service) Residents Peter Friedmann, M.D., MPH I Preceptor, Medical Primary Care Unit I Preceptor, Medical Primary Care Unit I Ambulatory Morning Report Teaching Sessions for I Clerkship or sub-intern involvement: One inpatient General Internal Medicine Residents ward month annually, 3-4 Brown students per week I ACGME Core Competency Retreat, Program in outpatient medical clinic. Coordinator & Speaker I Critical Appraisal, Motivational Interviewing, I Brown Medical School Graduate Medical Ambulatory Morning Report for General Internal Education Committee Medicine and Categorical Residents on Ambulatory I Internal Medicine Second Site Preceptor Block I Director, Center of Excellence, Education Component I Ward Attending - Med B (Inpatient Medical Service) I Member, Medical Faculty Executive Committee Jennifer Jeremiah, M.D. I Director, community based education/second site program

55 general internal medicine

Anne W. Moulton, M.D. Michael Stein, M.D. I Ward Attending - Med B (Inpatient Medical Service) I Clerkship and sub-intern involvement: Two inpatient I General Medicine Consult Ward Attending ward months annually, 2 Brown students per week in outpatient HIV clinic I Co-Director, Department of Medicine Residents Research Program I Co-Director, Brown Med. School HIV/AIDS elective I I Ambulatory Block for Categorical Program: HIV teaching, Motivational Interviewing during Block for residents2 internal medicine residents I Ambulatory Block for Primary Care Residents: 2nd site preceptorships I Preceptor, Medical Primary Care Unit I Internal Medicine Second Site Preceptor (categori- Michelle Stozek, M.D. cal and primary care program residents) at I Precpetor at Rhode Island Hospital and The Women’s Health Associates Miriam Hospital medical clinics I I Third year BMS Internal Medicine Clerkship Medical Director of the Miriam Medical Clinic (Preceptor) I Second site preceptor for medical resident I Third-fourth year rotation in longitudinal care in I Preceptor for 3rd year medical clerkship course Medical Primary Care Unit (Preceptor) I Ward attending at Rhode Island Hospital I Dean’s Letter writer/adviser for Fourth Year stu- I Ambulatory morning report preceptor dents going into medicine residency Dominick Tammaro, M.D. Paul Pirraglia, M.D., M.P.H. I Interviewing for Residency Programs, Co-Director, I Preceptor, Internal Medicine Journal Club, workshop for Brown Medical Students Providence Veterans Affairs Medical Center. I Small Group Facilitator, Clinical Teaching Seminars, I Brown Medical School, Tutor, Physical Diagnosis Categorical and General Internal Medicine I Brown Medical School, Preceptor, Core Clerkship I Residency Program Ambulatory Block Rotations in Medicine. I Small Group Facilitator, Medicare Billing and I Ward attending, Providence Veterans Affairs Documentation Seminars, Categorical and General Medical Center. I Internal Medicine Residency Program Ambulatory I Resident clinic preceptor, Miriam Hospital. Block Rotations Susan Ramsey, PhD I ACGME Core Competency Retreat, Program I Motivational Interviewing, Addictive Behaviors Coordinator & Speaker Seminar, Brown Medical School Psychology I Brown Medical School Graduate Medical Internship Program Education Committee I Coordinator, Adult Track Seminar Series, Brown I Service Attending, Med B Inpatient Service, Faculty Medical School Psychology Internship Program Instructor I General Internal Medicine Consultation Attending Benjamin Sapers, M.D. I I Preceptor, 3rd year Brown Medical School Internal Medical Intern Conference Co-Leader, weekly con- Medicine Clerkship ference I I Ward Attending, 5 months per year for housestaff Applying for Fellowships, Medicine Residency and medical students Noon Conference I I Outpatient Clinical Preceptor, full-time 7 months Medical Care of the Perioperative Patient, Grand per year, part-time 5 months per year Rounds, Worcester Medical Center I Morning Report: Fourteen Simultaneous Sessions Mark Schleinitz, M.D., MSc I Residency Site Review, Brown Medical School I Ward Attending, Providence VA Medical Center Psychiatry, Residency Program Reviewer/Consultant I General Medical Clinic Preceptor, Providence VA Medical Ctr Iris L. Tong, M.D. I Physical Diagnosis Course (run by Jack Schwartzwald, M.D.) for the 2nd year Brown 56 Medical students brown medical school department of medicine

I Rational Clinical Exam Course (run by Mark I Third year BMS Internal Medicine Clerkship Fagan) for the 3rd year BMS Preceptor I Ambulatory Morning Report Teaching Sessions for I Ward Attending - Med B (Inpatient Medical Service) General Internal Medicine Residents I General Medicine Consult Ward Attending I Evidence-Based Medicine Teaching Sessions for the I Resident Clinic Preceptor Categorical IM Residents I Resident Second-Site Preceptor I Problem based-learning sessions for the 3rd year BMS

GRADUATE CAREER CHOICES 2004 Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM Total Percentage Subspecialty Fellow 1 18 1 3 23 43% GIM Fellow 1 1 0 2 4% GIM Private Practice 2 2 3 7 13% MP Private Practice 0 0% GIM Hospital Practice 2 0 1 1 4 7% MP Hospital Practice 0 0% GIM/Public Health 0 0 0 0% Other/Research/Hospitalist 5 8 2 3 18 33% Total 11 29 4 10 54 100% GRADUATE CAREER CHOICES 2005

Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM Total Percentage Subspecialty Fellow 4 26 1 3 34 63% GIM Fellow 1 1 2 4% GIM Private Practice 3 2 2 7 13% MP Private Practice 1 1 2% GIM Hospital Practice 2 2 4 7% MP Hospital Practice 1 1 2% GIM/Public Health 0 0 0% Other/Research/Hospitalist 0 1 4 5 9% Total 10 31 4 9 54 100%

57 general internal medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL AY 2003 & 2004 Graduate’s Career Plans Categorical Internal Medicine Kamel Addo, MD, Hospitalist, The Miriam Hospital, Providence, Rhode Island Trimble Augur, MD, Hospitalist, Greater Baltimore Medical Center, Baltimore, MD Carrie Burns, MD, 2004 – Hospitalist, Philadelphia, PA, 2005 – Endocrinology Fellowship, University of Pennsylvania, Philadelphia, PA Venu Channamasetty, MD, Cardiology Fellowship, New York Medical College, Valhalla, NY Amy Chi, MD, Critical Care Research Fellow, University of California at San Francisco, San Francisco, CA Sooyun Chun, MD, Gastroenterology Fellowship, University of Cincinnati, Cincinnati, Ohio Amy Churchill, MD, General Medical Practice, Acton, MA Benjamin Conway, MD, Cardiology Fellowship, Maine Medical Center, Portland, ME Sarah Cutrona, MD, 2004-Hospitalist, Kent County Hospital, Warwick, RI, 2005-General Internal Medicine Fellowship, Harvard Medical School, Boston, MA Greg Gagliardi, MD, Gastroenterology Fellowship, Thomas Jefferson University, Philadelphia, PA Tara Iyengar, MD, 2005-Hematology-Oncology Fellowship, Brown Medical School, Providence, RI Michael Ham, MD, Nephrology Fellowship, Brown Medical School, Providence, RI Thomas Isaac, MD, 2004 – Chief Medical Resident, Brown Medical School, Providence, RI Amit Johnsingh, MD, 2004-Hospitalist, The Miriam Hospital, Providence, RI, 2005-Nephrology Fellowship, Brown Medical School, Providence, RI Robert Ludwig, MD, General Internal Medicine Practice, Cambridge, MA Paul Martin, MD, Hospitalist, The Miriam Hospital, Providence, RI Jennifer Moodie, MD, Neurology Residency, Brown Medical School, Providence, RI Elvis Pagan, MD, Obstetric Medicine Fellowship, Women & Infants Hospital of RI, Brown Medical School,Providence, RI Reina Pai, MD, Gastroenterology Fellowship, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Michael Papper, MD, Gastroenterology Fellowship, Robert Wood Johnson Medical School, New Brunswick, NJ Randall Pellish, MD, 2004 – Chief Medical Resident, 2005 – Gastroenterology Fellowship, Brown Medical, School, Providence, RI Michael Polsky, MD, Pulmonary Critical Care Fellowship, Brown Medical School, Providence, RI Usman Ramzan, MD, 2004-Hospitalist, Newport Hospital, Newport, Rhode Island, 2005- Pulmonary&Critical Care Fellowship, Thomas Jefferson Univ, Philadelphia, PA Miguel Rodriguez, MD, 2004 – Hospitalist, Holyoke Medical Center, Holyoke, MA Matthew Solitro, MD, Nephrology Fellowship, University of Massachusetts, Worcester, MA Katherine Thornton, MD, 2004 – General Internal Medicine Faculty, 2005 – Hematology-Oncology Fellowship, Johns Hopkins Hospital, Baltimore, MD Ana Tuya, MD, 2004 – Chief Medical Resident, 2005 – Geriatrics Fellowship, Brown Medical School, Providence, RI Sabrina Witherby, MD, Hematology-Oncology Fellowship, University of Vermont, Burlington, VT General Internal Medicine/Primary Care Anikke Cengel, MD, Hospitalist, Mercy Hospital, Portland, ME Kathryn Mehegan DeAnzeris, MD, Chief Medical Resident, Brown Medical School, Providence, RI Michele Goh, MD, Internal Medicine Practice, Charles River Medical Group, Hudson, Massachusetts Mary Hohenhaus, MD, Chief Medical Resident, Brown Medical School , Providence, RI Lori Lieberman-Maran, MD, Rheumatology Fellowship, Roger Williams Med. Center Program, Providence, RI Mercedes Murphy (Pacheco), MD, Primary Care Group, Morton Plant Mease Primary Care, Clearwater, FL Philip Russell, MD, Psychiatry Residency, Brown Med. School, Butler Hospital, Providence, RI Elizabeth Tillman, MD, Hospitalist, Cape Cod Hospital/Hospitalist Division, Hyannis, MA Lorna Weinheimer, MD, General Medicine Practice Joseph Wiener, MD, General Medicine Practice, NYC, NY 58 Edward Wu, MD, Clinician-Educator Fellowship, University of Pittsburgh, Pittsburgh, Pennsylvania brown medical school department of medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL AY 2003 & 2004 Graduate’s Career Plans continued

Combined Medicine & Pediatrics Blayne Cutler, MD, Infectious Diseases Fellowship, New York Presbyterian Hospital-(Columbia Campus) Program, New York, NY Isaac Dapkins, MD, Public Health "Health Care for the Homeless Program, Montifiore Hospital, Albert Einstein College of Medicine, NYC, NY Jeffrey Merkle, MD, Medicine/Pediatrics Hospitalist, Newton, NJ Joel Park III, MD, Hospitalist, Rhode Island Hospital, Providence, Rhode Island Chief Medical Residents David Benton, MD, Hematology-Oncology Fellowship, Brown Medical School, Providence, RI Miroslawa Jablonski-Cohen, MD, Cardiology Fellowship, Albert Einstein, Philadelphia, PA A. Chase Maxwell, MD, Attending/Academic Faculty, Brackenridge Hospital, Austin, TX Kristin Poshkus, MD, Women’s Health Practice, East Greenwich, RI John Snyder, MD, General Internal Medicine Faculty, Johns Hopkins Hospital, Baltimore, MD

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL AY 2004 & 2005 Graduate’s Career Plans Categorical Internal Medicine Khaled Abdel-Kader, MD, 2005 - Chief Medical Resident, Brown Medical School, Providence, RI, 2006 - Nephrology Fellowship, University of Pittsburgh Medical Center, Pittsburgh, PA Renee Elizabeth Amori, MD, Endocrinology, Diabetes and Metabolism Fellowship, Tufts-New England Medical Center, Boston, MA Elliott James Anderson, MD, 2005 – Hospitalist, Hawthorn Medical Associates, New Bedford, MA, 2006 - Hematology/Oncology Fellowship, Brown Medical School, Providence, RI Christina Seung Baik, MD, 2005 - Masters in Public Health, Harvard School of Public Health, Boston, MA, 2006 - Hematology/Oncology Fellowship, NEMC-Tufts Medical School Program, Boston, MA John Patrick Brennan, MD, Pulmonary Disease and Critical Care Fellowship, Tufts-New England Medical Center, Boston, MA Alison Rita Comite, MD, Clinician-Educator Faculty, Tufts-New England Medical Center, Boston, MA Vadim Fayngersh, MD, 2005 - Chief Medical Resident, Memorial Hospital of Rhode Island, Brown Medical School Affiliated Program, Pawtucket, RI, 2006 - Pulmonary and Critical Care Medicine Fellowship, Brown Medical School, Providence, RI Anthony John Febles, MD, Radiology Residency, University of Vermont, Burlington, Vermont Beth Ann Fisher, MD, Pulmonary, Critical Care and Sleep Medicine Fellowship Program, Mount Sinai School of Medicine New York, NY Soniya Sharad Gandhi, MD, 2006 - Infectious Disease Fellowship, Columbia College of Physicians and Surgeons New York Presbyterian Hospital, New York, NY, Ellen Leigh Hartmann-Chirichella, MD, Hematology/Oncology Fellowship, Brown Medical School, Providence, RI Joseph Hou, MD, 2005 – Hospitalist, The Miriam Hospital, Providence, RI, 2006 - Pulmonary & Critical Care Fellowship, Mount Sinai School of Med. Program, New York, NY Robert Bruce Holland, MD, Pulmonary Disease and Critical Care Fellowship, University of Wisconsin Program, Madison, WI Sujani Sarada Kakumanu, MD, Allergy Fellowship, University of Wisconsin Program, Madison, WI Christine Alice Kerr, MD, 2005 - Chief Medical Resident, Brown Medical School, Providence, RI, 2006 - Intectious Disease Fellowship, Columbia College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY 59 general internal medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL AY 2004 & 2005 Graduate’s Career Plans continued

Categorical Internal Medicine Emmy Ann Mahoney, MD, Cardiovascular Disease Fellowship, University of Connecticut, Hartford, CT John Omar Mascarenhas, MD, Hematology/Medical Oncology Fellowship, Mount Sinai Medical Center, New York, NY Tarun Mathur, MD, 2005 - Academic Teaching Attending/Hospitalist, Lankenau Hosp. TCC, Wynnewood, PA, 2006 - Cardiology Fellowship, University of Connecticut, Hartford, CT Jeffrey Michael Mazer, MD, 2005 Chief Medical Resident, Brown Medical School, Providence, RI, 2006 - Pulmonary and Critical Care Medicine Fellowship, Brown Medical School, Providence, RI Cara Eilese McLaughlin Gavin, MD, General Internal Medicine Fellowship, Harvard Medical School Faculty Development and Fellowship Program in General Internal Medicine, Boston, MA Cathryn Anne McNamara, MD, 9/2005 Group Practice, Harvard Vanguard Medical Associates, Quincy MA Stephan George Muhlebach, MD, 2005 - Hospitalist, Jordan Hospital, Plymouth, MA, 2006 - Cardiology Fellowship, Brown Medical School, Providence, RI Richard Andrew Regnante, MD, Cardiovascular Diseases Fellowship, Brown Medical School, Providence, RI Anna Grant Rudnicki, MD, 2005 – Hospitalist, Kent County Hospital, Warwick, RI, 2006 - Pulmonary & Critical Care Fellowship, Boston Univ. Medical Center Program, Boston, MA Daniel Alexander Selo, MD, 2005 - Chief Medical Resident, Brown Medical School, Providence, RI, 2006 - Gastroenterology Fellowship, Lahey Clinic Program, Burlington, MA Anisa Shaker, MD, Gastroenterology Fellowship, Washington University/Barnes/Saint Louis Hospital Consortium Program, St. Louis, MO Shivani Sood, MD, Gastroenterology Fellowship, North Shore Universital Hospital, NYU School of Medicine Program, Manhasset, NY Robert Andrew Swierupski, MD, Group Practice, Sturdy Memorial Hospital, Attleboro, MA Sejal Ashok Thaker, MD, 2005 – Hospitalist, Coastal Medical, Providence, RI, 2006 - Pulmonary and Critical Care Medicine Fellowship, Mount Sinai School of Medicine Program, New York, NY Raymond E. Tsao, MD, Hematology/Medical Oncology Fellowship, Cleveland Clinic Foundation Program, Cleveland, OH Barton Lahn Wise, MD, Rheumatology Fellowship, Boston University Medical Center Program, Boston, MA General Internal Medicine/Primary Care Laurel Athena Bliss, MD, Group Practice, University Medicine Foundation, Providence, RI Elisa Anne Freeman, MD, Private Practice, Caritas Good Samaritan Medical Practice Corp., Brockton, MA Allison Sonny Friedenberg, MD, 2005 - Chief Medical Resident, Brown Medical School, Providence, RI, 2006 - Pulmonary Disease and Critical Care Medicine. Fellowship, New York University Medical School, New York, NY Tara Catherine Lagu, MD, General Internal Medicine Fellowship, The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, Philadelphia, PA Catherine Ann Malone, MD, General Internal Medicine Faculty, Rhode Island Hospital, Brown Medical School, Providence, RI Donnah Mathews, MD, Geriatrics Medicine Fellowship, Brown Medical School, Providence, RI Bismruta Misra, MD, 2005 - General Internal Medicine Faculty, Rhode Island Hospital, Brown Medical School, Providence, RI. 2006 - Endocrinology, Diabetes, and Metabolism Fellowship, Columbia College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY Sheri Xue Qi, MD, Primary Care Practice, Harvard Vanguard Medical Associates, West Roxbury, MA Megan Ashley Tamburini, MD, Clinical Instructor in Medicine, SUNY Upstate Medical University, Syracuse, NY Traci Lynn Tupper, MD, Endocrinology, Diabetes and Metabolism Fellowship, Brown Medical School, Providence, RI

60 brown medical school department of medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL AY 2004 & 2005 Graduate’s Career Plans continued

Medicine-Pediatrics Jocelyn Paige Beattie Nolte, MD, Group Practice, Internal Medicine and Pediatrics, Palmyra Family and Internal Medicine-Hosp, Charlottesville, Virginia Joanna Danni Bell, MD, Hospital Practice, Assistant Professor of Medicine, Drexel Univ. College of Medicine Div of HIV/AIDS Medicine, Partnership Comprehensive Care Practice, Philadelphia, PA Loida Elena Bonney, MD, STD/HIV Prevention Research Fellowship, The Miriam Hospital, Brown Medical School, Providence, RI Anitha Sara John, MD, 2005 - Instructor in Medicine & Pediatrics, Harvard Medical School, Chelsea Health Care Center, Chelsea, MA, 2006 - Pediatric Cardiology Fellowship, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA Chief Medical Residents Mary Hohenhaus, MD, General Internal Medicine Faculty, The Miriam Hospital, Brown Medical School, Providence, RI Thomas Isaac, MD, General Internal Medicine Fellowship, Harvard Medical School &, Harvard School of Public Health, Boston, MA Kathryn Mehegan DeAnzeris, Private Practice, Newton-Wellesley Internists, Newton, MA Randall Pellish, MD, Gastroenterology Fellowship, Brown Medical School, Providence, RI Ana Tuya, MD, Geriatric Medicine Fellowship, Brown Medical School, Providence, RI

MEMORIAL HOSPITAL OF RHODE ISLAND AY 2004 & 2005 Graduate’s Career Plans

Internal Medicine Residency Program June 2004 Irfan Ahmad, MD, Internal Medicine Practice, Woonsocket, RI Rahul Ahuja, MD, Attending Physician,VA Hospital, North Carolina Kristine Cunniff, MD, Hospitalist ,South County Hospital,South County, Rhode Island Teresa Daniele, MD, Nuclear Cardiology Fellowship, College of Physicians & Surgeons of Columbia University, New York, NY Michael DiBari, MD, Internal Medicine Position, Mercy Medical Center, Long Island, NY Chuck Huang, MD, Endocrinology Fellowship, UCLA Harbor Medical Center, Los Angeles, California Mridula Menon, MD, General Internal Medicine Practice, Taunton, MA. Ami Muehlberg, MD, Dermatology at Skin Care, West Warwick, RI Lole Ribizzi-Akhtar, MD,Hematology/Oncology Fellowship, U MASS, Worcester, MA. Sally Stipho, MD, Chief Resident, Internal Medicine Residency, Memorial Hospital of Rhode Island, Pawtucket, RI June 2005 Ahmad Abu-Halimah, MD, Cardiology Fellowship, Vanderbilt University, Nashville, TN Joanne Castro, MD, Primary Care Physician Jonathan Costa, DO, Hospitalist, Falmouth Hospital, Massachusetts, 2006 Nephrology Fellowship at University of Massachusetts Michelle Costa, DO, Rheumatology Fellowship, Roger Williams Hospital, Providence, RI José Felix Huerta, MD (9/11/04-9/10/05), Primary Care Physician, Brennir Medical Group, Santa Cruz, CA Geraldina Kica, DO, Hospitalist Physician, Morton Hospital, Taunton MA, applying for Cardiology Fellowship July 2007 Hemchand Ramberan, MD, Gastroenterology Fellowship,Yale University, New Haven, Connecticut Rameshwar Reddy, MD, Hospitalist Medicine Kurush Setna, MD, Hospitalist Position, Memorial Hospital of Rhode Island 61 general internal medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL Current Residents 2005-2006 Chief Medical Residents Khaled Abdel-Kader, MD UMDNJ Jeffrey Mazer, MD Tufts University Alison Friedenberg, MD University of Wisconsin Daniel Selo, MD Indiana University Christine Kerr, MD University of Buffalo General Internal Medicine/Primary Care PGY-1 PGY-3 (8) 2003-2006 Jennifer Agosta, MD Univ. of New Mexico Srividya Anandan, MD Tufts University Luis Bent-Shaw, MD Albert Einstein College Thomas Doyle, MD Brown Medical School Judy Blair, MD Univ. of California, San Fran Julie (Bard) Fogarty, MD University of Vermont Chloeanne Estrera, MD Univ. of Virginia Luke Hansen, MD Loyola University Sarah Tapyrik, MD Univ. of Rochester Sumana Kesh, MD Drexel University Carol Touma, MD Univ. of Kentucky Mara Linscott, MD SUNY Buffalo Rimini Varghese, MD UMDNJ- R. W. Johnson Alisa Merolli, MD Drexel University Jennifer Villa, MD Temple University Nora Taylor, MD Eastern Virginia Sarita Warrier, MD Univ. of Michigan

PGY-2 Lauren Beste, MD Johns Hopkins Courtney Clark, MD Chicago Med School John Gelzhiser, MD Drexel University Melinda Hooton, MD West Virginia University Jamie Kemp, MD Washington University Kathryn Koncsol, MD Temple University Ting Kuang, MD New York Medical College Andrew Levinson, MD Drexel University Matthew Tracy, MD McGill University Leah Urbaniak, MD Georgetown University Categorical Internal Medicine PGY-1 Sinan Kutty, MD UMDNJ- RW Johnson John Adams, MD University of North Carolina William “Tony” University of Tennessee Dipesh Amin, MD University of Colorado Lizarraga, MD Scott Brancato, MD Georgetown University Elias Loukas, MD SUNY Downstate Med Univ. Marilena Caldarusa, MD Dartmouth Medical School Ryan MacNevin, MD University of Maryland Lee Campano, MD Chicago Medical School Rupesh Mehta, MD SUNY Upstate Med Patrick Chun, MD Michigan State University University Furha Cossor, MD University of Missouri Jonathan Nass, MD Tulane University Ann Dennis, MD University of New Mexico Reve Purisima, MD SUNY Upstate Med Kathleen Doyle, MD University of Connecticut University David Epstein, MD University of Miami Natalie Ramezani, MD University of South Florida Katherine Faricy Jefferson Medical College Joyce Reyes University of Rochester Anderson, MD Thomas, MD Rebecca Fitch, MD SUNY Downstate Med Univ. Kristin Scott-Tillery, MD University of Texas Christopher Fyock, MD Med. Univ. of S. Carolina Fuad Said, MD University of Jordan Ravi Gupta, MD SUNY Downstate Med Univ. William Speicher, MD Temple University Jung-ah Han, MD Albert Einstein College Nicole University of Massachusetts Sameer Jamal, MD Virginia Commonwealth Univ. Theodoropoulos, MD Kristel Jernigan, MD Brody School of Medicine Erich Vorlop, MD University of Buffalo

62 brown medical school department of medicine

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL Current Residents 2005-2006 continued Categorical Internal Medicine

PGY-2 PGY-3 (8) 2003-2006 Gloria Aggrey, MD Case Western Reserve George Bayliss, MD Brown Medical School Anna Barbosa, MD Boston University Matthew Buchalter, MD NY Medical College Hanna Ahmed, MD Tufts University Megan Callahan, MD Tufts University Marla Barkoff, MD Boston University Bradley Collins, MD Penn State Jessica Barry, MD University of Kansas Susan Eckert, MD Albany Medical College Michael Blundin, MD Penn State Robert El-Kareh, MD Temple University Eric Gartman, MD University of Rochester Scott Ferreira, MD Tulane University Julie Guilbert, MD UMass Andrew Freeman, MD SUNY Buffalo Luis M. Henkel, MD Univ Federal Do Rio Grande Mita Gupta, MD New York Medical College Do Sul Rebecca Hirsh, MD Brown Medical School Siddharth Kakodkar, MD University of Illinois Joseph Hou, MD Brown Medical School Charles Lane, MD UMass Christopher Hurt, MD University of Florida Sheen Yee Lim, MD Jefferson Medical College Lisa Kallenbach, MD Brown Medical School Amitoj Marwaha, MD Medical College of Corey Karlin, MD SUNY Stony Brook Wisconsin Prabhav Kenkre, MD University of New Mexico Matthew Myers, MD Drexel University Olga Lurye, MD University of Maryland Kimberly Perez, MD George Washington Univ. Douglas Martin, MD University of Rochester Thao Pham, MD New York Medical College Mitchell McClure, MD University of Connecticut Samuel Poon, MD Albert Einstein College of Med Erin McGeeney, MD University of Missouri Matthew University of Massachusetts Eric Newton, MD University of Vermont Quesenberry, MD Brian Phillips, MD UMDNJ - RW Johnson Akshay Shah, MD Albert Einstein College of Med Angela Plette, MD University of Massachusetts Joshua Shipley, MD Drexel University Katherine Richman, MD Brown Medical School Rebecca Starr, MD SUNY - Downstate Jessica Salt, MD Virginia Commonwealth Univ. Jennifer Suga, MD Tufts University Yon Sung, MD University of Pittsburgh Sarah Tsiaras, MD Harvard Medical School Corey Ventetuolo, MD Tufts University Lori Vales, MD UMDNJ - NJ Medical School Michael Via, MD New York Medical School Scott Walker, MD University of Connecticut James Yess, MD Loyola University Danya Wenzler, MD UMDNJ - NJ Medical School Patricia Zappa, MD Wayne State University Jordan Wolff, MD University of Maryland Todd Wood, MD Case Western Reserve Ian Wu, MD University of Maryland

Medicine-Pediatrics PGY-1 PGY-3 George Hardy, MD Brown Medical School Scott Cohen, MD Saint Louis University Marisa Holubar, MD University of Wisconsin Michael Connor, MD Medical College of Georgia Julia Ozbolt, MD Univ. of CA, San Diego Meghan Eckstein, MD Georgetown University Susan Paul, MD University of Massachusetts Jessica Fairley, MD Georgetown University Traci Wolbrink, MD Michigan State University PGY-2 Sabrina Assoumou, MD Univ. of Rochester PGY-4 Kerri Nottage, MD Brown Medical School Erica Blood, MD Geo Washington Univ. Edmund Sears, MD Brown Medical School Chadwick Johr, MD Pennsylvania State Univ. Jennifer Turner, MD Georgetown University Kristin Lehr Albany Medical College Anderson, MD

63 general internal medicine

MEMORIAL HOSPITAL OF RHODE ISLAND Current Residents 2005-2006 Internal Medicine Chief Resident PGY-2 Vadim Fayngersh, MD Ben Gurion University of Purva Agarwal, MD Jawaharlal Nehru Medical the Negev in Collaboration College with Columbia University Alexey Danilov, MD Jaroslavl State Medical Health Sciences, Brown Academy Medical School Internal Bhupesh Dhananjayan, MD Lokmanya Tilak Municipal Medicine Residency, Rhode Medical College Island Hospital Milan Mathew, MD Medical College Kottayam Maria Modesto, MD University of Santo Tomas PGY-1 Hoveda Mufti, MD Baqai Medical & Dental Hesham Aboshady, MD University of Cairo, Egypt College Theresa De Los Reyes, MD University Of Santo Tomas, Syed Nabi, MD Dow Medical College Phillipines Omar Saeed, MD Aga Kahn University Amber Gul, MD Allama Iqbal Medical Alberto Savoretti, MD Brown Medical School College, Pakistan Richard Van New York Medical Mohammad Hajjiri, MD Ain Shams University, Egypt Nieuwenhuize, MD College/Fifth Pathway Adriana Hosu, MD Universitatea De Medicina Si Farmacie Carol Davila, PGY-3 Romania Christina Anderlind, MD Humboldt-Universitat Ambreen Ijaz, MD Fatima Jinnah Medical Berlin College For Women, Pakistan Anjali Basil, MD India Gandhi Medical Omeed Sani, MD University Of Szeged College Medical And Medical James Benedict, MD Ross University Sciences Centre, Hungary Manuel Cunanan, MD Universidad Autonoma de Frederick Troncales, MD University Of Santo Tomas, Guadalajara Philippines Mina Guico, MD University of Santo Tomas, Syed Zulquernain, MD Ayub Medical College, Phillippines Pakistan Majd Jwied, MD University of Jordan Mutaz Labib, MD Dokuz Eylul Universitesi Raissa Paredes, MD University of the East, Phillippines Eleni Patrozou, MD University of Athens Kevin Price, DO Philadelphia College of Osteopathic Med Richard Ruffin, MD The University of the West Indies

SELECTED PUBLICATIONS I Tammaro D, McGarry KA, Cyr MG. Perioperative Care of the Patient with Hip Fracture. Michele Cyr, M.D. Comprehensive Therapy 2004; 29(4): 233-243. I Chlebowski RT, Hendrix S, Langer RD, Stefanick I McGarry KA, Cyr MG. Principles of Diagnosing ML, Gass M, Lane D, Rodabough RJ, Gilligan MA, and Managing Postmenopausal Osteoporosis for Cyr MG, Thomson CA, Khandekar J, Petrovich H, the Podiatric Physician. Journal of the American McTiernan A. Influence of Estrogen Plus Progestin Podiatric Medical Association 2004; 94(2): 187-193. on Breast Cancer and Mammography. JAMA 2003, I David SP, Eaton CB, Scott Taylor J, Stamp MJ, Cyr 289(24): 3243-3253. MG, Siegel B, Gramling R, and Walton R. Envisaging and Applying a Unifying Three-Dimensional Theoretical Framework for Generalist Physicians. 64 Medicine and Health 2004;87(11):336-340. brown medical school department of medicine

I McGarry KA, Cyr MG. Women and Alcohol. I Sidlow R, Mechaber AJ, Reddy S, Fagan MJ, Comprehensive Therapy 2005;31(1):83-93. Marantz PR. The Internal Medicine Subinternship. I Duffy C, Cyr MG. The Relationship Among A Curriculum Needs Assessment. JGIM 2002, vol. Alcohol, Folate and Breast Cancer Risk. The Brown 17;7:561-564. University Digest of Addiction Theory and I Griffith R, Fagan MJ, Obbard L, O’Connor C. Can Application (DATA) 2005:24(3);8. an Evidence-Based Approach Resuscitate Medical Students’ Skill in Physical Diagnosis? Accepted for Nanada F. Col, MD, MPH, MPP publication JGIM, March, 2003 I Col NF, Pauker SG. Discrepancy between observa- I Fagan, MJ, Diaz J. Impact of Interpretation Methods tional studies and randomized trials of menopausal on Clinic Visit Length. Accepted for publication, hormone therapy: Did expectations shape experi- JGIM, March 2003. ence? Ann Intern Med, 2003;139:923-929. I Roth CS, Fagan MJ, Griffith JM, Nelson D, Zhao I Col NF, Surks MI, Daniels GH. Subclinical Thyroid Yanli. Evaluation of a Worksheet to Structure Disease: Clinical Context. JAMA 2004;291:239-243. Teaching and Learning Outpatient Internal I Col NF, Weber G, Stiggelbout A, Chuo J, D’Agostino Medicine. Medical Teacher. 2003 25;(3):311-316 R, Corso P. Short-term menopausal hormone thera- Peter Friedmann, M.D., MPH py for symptom relief: An updated decision model. Arch Intern Med, 2004;164:1634-1640. I Warner EA, Walker RM, Friedmann PD. Should informed consent be required for laboratory testing I Col NF. Challenges in Translating Research into for drugs of abuse in medical settings? Am J Med. Practice. J Women’s Health. 2005;14(1):87- 95. 2003; 115:54-58. I Col NF, Kim JA, Chlebowski RT. Menopausal hor- I Allen SA, Rich JD, Schwartzapfel B, Friedmann PD. mone therapy after breast cancer: A Meta-analysis Hepatitis C among offenders: correctional challenge and critical appraisal of the evidence. Breast Cancer and public health opportunity. Federal Probation. Research 2005, 7:R535-R540 2003; 67(2):22-26. Christine Duffy, MD, MPH I Friedmann PD, Hendrickson J, Gerstein DR, Zhang I Duffy CM, Cyr M. Phytoestrogens: Potential bene- Z. Designated case managers as facilitators of med- fits and implications for breast cancer survivors. ical and psychosocial service delivery in addiction Journal of Women’s Health. 2003;12:617-632. treatment programs. J Behav Health Serv Res. I Duffy CM, Allen SM, Clarke MA. Discussions 2004;31(1):86-97. regarding reproductive health for young women I Lemon SC, Rakowski W, Clark MA, Roy J, with breast cancer undergoing chemotherapy. J Clin Friedmann PD. Variations in influenza vaccination Oncol. 2005; 23: 766- 773. among the elderly. Am J Health Behav. I Col NF, Duffy C, Landau C. Surgical Decisions after 2004;28(4):352-360. breast cancer: Can patients be too Involved in deci- I Friedmann PD, Hendrickson J, Zhang Z, Gerstein sion-making? Health Services Research, DR. The effect of matching comprehensive services 2005:40(3):769-780. to patients’ needs on drug use improvement in I Gramling R, Duffy C, David S. Does providing addiction treatment. Addiction. 2004;99:962-972. hereditary breast cancer risk assessment support to Kelly McGarry, M.D. practicing physicians decrease the likelihood of I McGarry KA, Tammaro D, Cyr MG. Diagnosing them discussing such risk with their patients? Genet and managing postmenopausal osteoporosis: Med. 2004 Nov-Dec;6(6):542. Opportunities for fracture prevention. Mark Fagan, M.D. Comprehensive Therapy, 2003;29(2):115-123. I Elnicki D M, Curry RH, Fagan MJ, Friedman E, et I Tammaro D, McGarry KA, Cyr MG. Perioperative al. Medical Students’ Perspectives on and Responses care of the patient with hip fracture. Comprehensive to Abuse During the Internal Medicine Clerkship. Therapy 2003;29(4):233-244. Teaching and Learning in Medicine; An I McGarry KA, Cyr MG. Principles of diagnosing International Journal 2002, 13(2):92-97. and managing postmenopausal osteoporosis for the podiatrist. Journal of the American Podiatric Medical Association 2004;94(2):187-193. 65 general internal medicine

I McGarry KA, Cyr MG. Women and Alcohol. I Ramsey, S.E., Engler, P.A., & Stein, M.D. (2005). Comprehensive Therapy 2005;31(1):83-93. Alcohol use among depressed patients: The need I McGarry KA, Clarke JG, Landau C, Cyr MG. for assessment and intervention. Professional Caring for vulnerable populations: Curricula in US Psychology: Research and Practice, 36(2), 203-207. internal medicine residencies. Journal of I Ramsey, S.E., Brown, R.A., Strong, D.R., Stuart, G.L., Homosexuality 2005 (accepted) & Weinstock, M.C. (in press). Cigarette smoking and substance use among adolescents in psychiatric Paul Pirraglia, M.D., M.P.H. treatment. Journal of Child and Adolescent Substance I Pirraglia PA, Stafford RS, Singer DE. Trends in pre- Abuse. scribing of selective serotonin reuptake inhibitors and other newer antidepressant agents in adult Jennifer S. Rose, Ph.D primary care. The Primary Care Companion to the I Sherman, S.J., Rose, J.S., Koch, K., Chassin, L., & Journal of Clinical Psychiatry 5:153-157, 2003. Presson, C.C. (2003). Implicit and explicit attitudes I Grant RW, Pirraglia PA, Meigs J, Singer DE. Trends toward cigarette smoking: The effects of context in complexity of care in the United States from and motivation, Journal of Social and Clinical 1991 to 2000 for patients with diabetes. Archives of Psychology, 22, 13-39. Internal Medicine 164:1134-1139, 2004. I Rosengard C, Clarke JG, DaSilva, K, Hebert M, I Pirraglia PA, Sanyal P, Singer DE, Ferris TG. Rose J, Stein MD. Correlates of partner- specific Depressive symptom burden as a barrier to screen- condom use intentions among incarcerated women ing for breast and cervical cancer. Journal of in Rhode Island. Perspectives on Sexual and Women’s Health, 13(6):731-738, 2004. Reproductive Health 2005; 37(1):32-38. I Pirraglia PA, Rosen AB, Hermann RC, Olchanski NV, Cynthia Rosengard, PhD, MPH Neumann P. Cost-utility analysis studies of depres- I Rosengard, C., Clarke, J. G., DaSilva, K., Hebert, M. sion management: a systematic review. American R., Rose, J., & Stein, M. D. (2005). Correlates of Journal of Psychiatry, 161(12): 2155-2162, 2004. partner-specific condom intentions among incar- I Pirraglia, PA, Bishop D, Herman DS, Trisvan E, cerated women in Rhode Island. Perspectives on Lopez RA, Torgersen CS, Van Hof AM, Anderson BJ, Sexual and Reproductive Health, 37(1), 32-38. Miller I, Stein MD. Caregiver burden and depression I Rosengard, C., Phipps, M., Adler, N. E., & Ellen, J. among informal caregivers of HIV-infected individ- M. (2004). Adolescent pregnancy intentions and uals. J Gen Intern Med. 2005 Jun;20(6):510-4. pregnancy outcomes: A longitudinal examination. Journal of Adolescent Health, 35(6), 453-461. Roy Poses, M.D. I I Poses RM. A cautionary tale: The dysfunction of Rosengard, C., Anderson, B., & Stein, M. D. (2004). American health care. Eur J Int Med 2003; 14: 123-130. Intravenous drug users’ HIV risk behaviors with primary/other partners. The American Journal of Susan Ramsey, PhD Drug and Alcohol Abuse, 30(2), 225-236. I Ramsey, S.E., Strong, D.R., Stuart, G.L., Weinstock, I Rosengard, C., Adler, N. E., Millstein, S. G., Gurvey, M.C., Williams, L.A., Tarnoff, G., Picotte-Prillmayer, J. E. & Ellen, J.M. (2004). Perceived STD risk, rela- D.M., & Brown, R.A. (2003). Substance use and diag- tionship and health values in adolescents’ delaying nostic characteristics that differentiate smoking and sexual intercourse with new partners. Sexually non-smoking adolescents in a psychiatric setting. Transmitted Infections, 80(2), 130-137. Journal of Nervous and Mental Disease, 191, 759-762. I Ramsey, S.E., Kahler, C.W., Read, J.P., Stuart, G.L., Mark Schleinitz, M.D., M.S. & Brown, R.A. (2004). Discriminating between I Bravata, D.M., Sundaram, V., McDonald, K.M., substance-induced and independent depressive Smith, W.M., Szeto, H., Schleinitz, M.D. and Owens, episodes in alcohol dependent patients. Journal of D.K. Evaluating detection and diagnostic decision Studies on Alcohol, 65(5), 672-676. support systems for bioterrorism response. 2004. Emerg Infect Dis. 10(1):100-8. I Ramsey, S.E., Engler, P.A., & Stein, M.D. (2004). The negative impact of alcohol use among depressed I Schleinitz, M.D., Weiss, J.P. and Owens, D.K. patients. DATA: The Brown University Digest of Clopidogrel versus aspirin for secondary prophylaxis Addiction Theory and Application, 23(11), 8. of thrombotic events: a cost-effectiveness analysis. 66 2004. Am J Med. 116(12): 797-806. brown medical school department of medicine

I Schleinitz, M.D., Olkin, I. and Heidenreich, P. I Stein MD, Solomon DA, Herman DS, Anthony JL, Cilostazol, clopidogrel or ticlopidine to prevent Ramsey SE, Anderson BJ, Miller I. sub-acute stent thrombosis: a meta-analysis of ran- Pharmacotherapy plus psychotherapy for treatment domized trials. 2004. Am Heart J. 148(6): 990-997. of depression in active injection drug users. Arch I Schleinitz, M.D. and Heidenreich, P.A. A cost-effec- Gen Psych 2004;61:152-59. tiveness analysis of combination antiplatelet therapy I Stein MD, Herman DS, Solomon DA, Anthony JL, for high-risk acute coronary syndromes: clopidogrel Anderson BJ, Ramsey SE, Miller I. Adherence to treat- plus aspirin versus aspirin alone. 2005. Ann Intern ment of depression in active injection drug users: The Med. 142(4):251-259. Minerva Study. J Sub Abuse Treat 2004;26:87-93. I Stein MD, Herman DS, Bishop S, Lassor JA, Michael Stein, M.D. Weinstock M, Anthony J, Anderson BJ. Sleep distur- I Stein MD, Anderson BJ. Injection frequency mediates bances among methadone maintained patients. J health service use among persons with a history of Sub Abuse Treat 2004;26:175-180. drug injection. Drug Alcohol Depend, 2003;70:159-68. I Stein MD, Anderson BJ. Nicotine and drug interaction Dominick Tammaro, M.D. expectancies among methadone maintained cigarette I McGarry K, Cyr M, Tammaro D. Diagnosing and smokers. J Sub Abuse Treatment, 2003;24:357-61. Managing Post-Menopausal Osteoporosis: I Stein MD, Solomon DA, Herman DS, Anderson BJ, Opportunities for Fracture Prevention. Miller I. Depression severity and HIV injection risk Comprehensive Therapy 29(2-3):115-23, July 2003. behavior. Am J Psychiatry 2003;160:1659-62. Listings are limited to the 5 most recent publications per faculty member.

RESEARCH

Direct Indirect Total

Total Clinical Research Expenses Academic Year 2003 $3,994,652 $919,415 $4,914,067 for General Internal Medicine Academic Year 2004 $4,314,098 $1,180,520 $5,494,618

CLINICAL RESEARCH Peter Friedmann, M.D. I Trazodone for Sleep Disturbance in Early Alcohol Jennifer Clarke, M.D. Recovery. NIH/National Institute on Alcohol Abuse I Women Leaving Prison: Two Models of Family and Alcoholism Planning Service Delivery. Department of Health I Linkage to Health Services in Drug Abuse and Human Services Treatment. NIH/National Institute on Drug Abuse I Women in Prison: Decreasing Unplanned I Continuity of Care for Drug - Addicted Offenders Pregnancies & STDs. NIH/National Institute for in RI. NIH/National Institute on Drug Abuse Child Health and Development I Integrating Buprenorphine Opioid Treatment with HIV Primary Care. Miriam Hospital/HRSA Nananda Col, M.D. I I A Menopause Interactive Decision Aid System. DATTS. University of Michigan NIH/Agency for Healthcare Research and Quality I CBT for Insomnia. Brown/NIH I Effective Brief Behavioral Interventions. I Program to Integrate Psychosocial & Health Services NIH/Agency for Healthcare Research and Quality in Chronic Disease & Disability. Department of Veterans Affairs-Health Services R&D Christine Duffy, M.D. I Trazadone for Sleep Disturbance - Early Alcohol I BIRCWH Scholarship - Identifying and Addressing Recovery. the Primary Care Health Issues of Cancer Survivors. Women & Infants Hospital of Rhode Island/ORWH

67 general internal medicine

Laura Ofstead, M.D. I A Multi, Double-Blin, Randomized Pilot Study to I A Menopause Interactive Decision Aid System. Compare the Safety and Activity. Miriam Hospital NIH/Agency for Healthcare Research and Quality I Smoking Cessation Among Methadone Maintained Patients. National Institute of Health Susan Ramsey, Ph.D. I I Preventing Depression in MMT Patients on A Trial to Reduce Hepatitis C Among Injection Interferon. National Institute on Drug Abuse Drug Users. National Institute of Health I I Improving Smoking Cessation Outcomes in Heavy A Brief Alcohol Intervention for Incarcerated Women. Drinkers. Brown University/NIDA National Institute on Alcohol Abuse and Alcoholism I I Brief Alcohol Intervention with Depressed Patients. Adult Therapeutic Clinical Trials Program for National Institute on Alcohol Abuse and Alcoholism HIV/AIDS. Miriam Hospital/NIH I I Brief Intervention to Reduce Drinking Among Antidepressant Treatment to Reduce HIV Risk Among Batterers. Butler Hospital/NIMH IDUs. NIH/National Institute of Mental Health I A Study Comparing the Safety and Tolerability of a Cynthia Rosengard, Ph.D. Tenofovir - Based Expanded PEP Regimen to a I Partner-Specific Factors in Adolescent Sexual Standard Protease Inhibitor-Based PEP Regimen Behavior. NIH/National Institute of Mental Health for Subjects with Occupational Exposure to Source Mark Schleinitz, M.D. Patients with Human Immunodeficiency Virus Infection. Gilead Sciences I Women and Infants BIRCWH Scholarship Award. NIH/Women and Infants Hospital I Antidepressant Treatment. NIH/NIMH I Screening Breast Ultrasound in High-Risk Women. I HIV Smokers. Miriam Hospital/NIH American College of Radiology/NCI Dominick Tammaro, M.D. H. Denman Scott, M.D I Residency Training in General Internal I Volunteers in Health Care. Robert Wood Johnson Medicine/Pediatrics. Bureau of Health Professions, HRSA

Michael Stein, M.D. I Mid-Career Investigator Award in Substance Abuse – Research. National Institute on Drug Abuse

68 brown medical school department of medicine

GERIATRICS OVERVIEW

he past two academic years of the Division have been dynamic; although clinical and educational Tgrowth begun in 2000 have continued, major changes occurred. Division faculty since Dr. Besdine’s arrival have grown from two full-time geriatricians in 2000 to 6, with the recruitment of Drs. Besdine, Dosa, Nanda and McNicoll (FT) and Dr. Teno (part time). Dr. Besdine was appointed Interim Dean of Medicine and Biological Sciences at Brown University, and on July 1, 2002, he began serving as dean, retaining lead- ership responsibilities for the Division and for the Center for Gerontology and Healthcare Research. Dr. John Murphy, Professor of Family Medicine and a national leader in aging, was recruited (began 7/03) as Associate Division Director, and David Dosa, M.D., MPH, was recruited as Assistant Professor of Medicine. In 2002, Robert Crausman, MD, was recruited to serve as director of the RI Board of Medical Licensure and Discipline. In March 2005, David Gifford, MD, MPH, associate professor in the Richard W. Besdine, M.D., Professor of Medicine, Rhode division, was recruited away by the Governor to be Island Hospital, University Medicine Foundation; Director, director of the State Health Department. Division of Geriatrics Newly established clinical programs in geriatrics The geriatric medicine fellowship program was fully include ambulatory primary and consultative care at accredited and enrolled three fellows in 6/02. One the East Avenue office, in-patient primary and consul- graduated after the one mandatory clinical year tative care at RIH and TMH, and a nurse practitioner- (employed as primary care clinician, emphasizing led home care program. A pilot in-patient program to geriatrics); one after a second year of teacher-clinician enhance geriatrics care was begun on one nursing unit training (faculty in the Harvard aging program, teach- at TMH in the fall of 2002, under Dr. McNicoll’s lead- ing and delivering care at the Hebrew Rehab Center); ership; outcome data are very positive, and plans for and the third graduated after the three-year program dissemination hospital-wide and to RIH are underway. (including the MPH curriculum) of preparation for a The division continues to participate in other quality research-intensive career 6/05 and was recruited to a improvement initiatives at TMH and RIH to improve junior faculty research-career development program at quality of care for older hospitalized patients. The the University of Pittsburgh. Two fellows enrolled 7/03, Division’s nursing home practice has doubled, and one for one year (now practicing geriatrics in New major enhancement of care at Providence Housing England) and one in the three-year track. Two fellows Authority sites has been achieved. Research productiv- enrolled in 7/04, and again one in the one-year and one ity of the Division has been concentrated at the in the three-year track. Clinical sites for training Gerontology Center (primarily health services include RIH, TMH, Memorial and Butler Hospitals, research), one of the Public Health-related research Steere House Nursing Home, CareLink, Hospice Care centers at Brown. Research activities of Drs. Besdine, of RI, East Avenue geriatrics primary ambulatory care Gifford and Teno occur in the setting of the Center; its practice, and multiple sites of ambulatory specialty productivity has increased substantially over the past care. Research training occurs within the public health two years in spite of no new faculty additions since program at Brown; fellows apply to the MPH program 2000. Its 13 full-time faculty hold more than 40 active and to the postdoctoral research training program at grants, funding is more than $5 million, and publica- the Center for Gerontology and Healthcare Research, tions average nearly 100 annually. The competitive and are mentored by Center faculty members. renewal application for the federally funded post-doc- 69 geriatrics

toral research fellowship training grant in aging and rated with Professor Tatar of Ecology and volutionary healthcare services was successful, bringing in Biology on submission of a large NIH Center Grant $300,000/year for 5 years; in addition, a 5th post- (PO1) to study biological aging in nonhuman primates; doctoral slot was awarded to the program in a funding the site visit was positive and the resubmission in climate that resulted in reduction of slots for many October has a strong probability of funding. competing programs. The Gerontology Center collabo-

FACULTY TRANSITIONS Departing Faculty

James Burrill, M.D., Clinical Assistant Professor Robert Crausman, M.D., Associate Professor of Medicine David Gifford, M.D., M.P.H., Associate Professor of Medicine Henry Izeman, M.D., Clinical Associate Professor of Medicine

FACULTY MEMBERS I Interim Dean of Medicine and Biological Sciences, Brown University FULL-TIME FACULTY (Hospital and Foundation Based) I Member, Board of Directors and Executive Richard W. Besdine, M.D., Professor of Medicine, Rhode Committee of the Board, American Geriatrics Society Island Hospital, University Medicine Foundation I President, American Geriatrics Society, 2003-04 David M. Dosa, M.D., M.P.H., Assistant Professor of I Board Chair, American Geriatrics Society, 2004-05 Medicine, Rhode Island Hospital, University I Member, Board of Directors, American Federation Medicine Foundation for Aging Research David R. Gifford, M.D., M.P.H., Assistant Professor of I Interim Chief Medical Officer, Quality Partners of Medicine, Rhode Island Hospital, University Rhode Island Medicine Foundation I Member, Board of Trustees, Education and Lynn McNicoll, M.D., Assistant Professor of Research Foundation, American Society of Medicine, Rhode Island Hospital, University Consulting Pharmacists Medicine Foundation I Best Doctors in America, Geriatric Medicine, 2005 John B. Murphy, M.D., Professor of Medicine, Rhode I Top Doc Award, Geriatrics, Rhode Island Monthly Island Hospital, University Medicine Foundation Magazine 2002, 03 Aman Nanda, M.D., Assistant Professor of Medicine, I Keen Award, Brown Medical School Alumni Rhode Island Hospital, University Medicine Foundation Association, 2005 Tom J. Wachtel, M.D., Professor of Medicine, Rhode I Faculty Award, Brown Medical School class of 2005 Island Hospital, University Medicine Foundation Joan Teno, M.D., Professor of Medicine and David M. Dosa, M.D., M.P.H. Community Health, Brown Medical School I Surdna Fellowship Recipient, Brown University I American Medical Association: Physician NATIONAL AND INTERNATIONAL Recognition Award, 2004 HONORS AND RECOGNITION I Keynote Speaker: Technical Expert Panel on OF FACULTY Nursing Home Care Planning, Agency for Health Care Research and Quality, September 2004. I Reviewer: Journal of the American Medical Director Richard W. Besdine, M.D. Association (JAMDA) I Greer Professor of Geriatric Medicine, Brown Medical School 70 brown medical school department of medicine

Reviewer: Aman Nanda, M.D. I American Board of Internal Medicine: Geriatrics Invited Presentations: Examination I Speaker, Geriatric Fundamental series – ‘Chronic Poster Presentation: Dizziness in Older Persons’ July 2003-4 I Dosa, D, Gifford DR, Carter D, Bowers, B. I Speaker, Geriatric Fundamental series – Medical “Perceptions of the Resident Assessment Protocols Directorship series (4 lectures) 2003 & 2004. (RAPs) in nursing home care planning”.American 1.Role of Medical Director in Nursing Home. Geriatrics Society Meeting, 2005 2. Role of Attending Physician and Nurse Poster Presentation: Practitioner. I Dosa, D, Gifford DR. “Critical Review of the 3. Billing and Coding. Resident Assessment Protocols (RAPs)”.American Geriatrics Society Meeting, 2005. 4. Subacute Care / Special issues. I Participated in presentation on ‘Timely Access to Lynn McNicoll, M.D., F.R.C.P.C. Hospice Care in Nursing Homes: Understanding I Top Doc Award for Women, Geriatrics, Rhode the Barriers and Influencing Change.’ Miller S, Island Monthly Magazine 2003, 2004 Welch L, Martin E, Nanda A. at Attorney General I Lifespan Barnett Fain Quality Improvement Award Task Force meeting on End of Life Care in Rhode 2003– Awarded to the best quality improvement Island on Nov. 05, 2004. project within the Lifespan organization, given at the I Speaker in workshop on ‘Education in Long-Term 2003 Lifespan Annual Meeting in Providence, RI. I Care’ at National Conference of American Medical was the primary medical and research consultant for Director Association on March 20, 2005 in New this project. The pilot unit also won the Patient Orleans, LA. Satisfaction Award 2004 for the Miriam Hospital. I Question Reviewer for Geriatric Medicine, I Best Paper Section of Neurology and Behavioral American Board of Internal Medicine from Nov. Sciences Award - Given to the best abstract in the 2004 to present. section of Neurology and Behavioral Sciences at the I Member, Task Force to Improve End of Life Care, American Geriatrics Society 2004 Annual Meeting Attorney General Office, RI. from Nov. 2004 to in Las Vegas, NV. present. Medical Journal Reviewer: I Member steering committee, RI Chapter of I Journal of the American Geriatric Society American Medical Director Association. Invited Presentations: I Rhode Island Quality Partners “Delirium in Joan M. Teno, M.D., M.S. Nursing Home Residents” March and June 2003 I Chair AGS Ethics Committee I RIH Grand Rounds “Update in Geriatrics: Delirium I Editorial Advisory Board, Journal of Pain and in Older Persons” July 2003 Symptom Management, 2001 to present I Editorial Board, Journal of Palliative Medicine, John Murphy, M.D. 2000 to present. Invited Presentations: I American Geriatrics Society Best Paper Award for I “Health Issues for Older Men”.Men’s Health Care: An American Crisis. Brown Medical School, Westin Geriatrics: Ethics and Quality of Life in May 2005 Hotel, Providence, RI April 30, 2004. at the Annual American Geriatrics Society Meeting in Orlando, FL. I “Influenza: Implications for an Aging Population”. I Second Annual Update in Internal Medicine, Brown 2005 American Academy of Hospice and Palliative Medical School, Radisson Airport Hotel, May 7, 2004. Medicine (AAHPM) Award for Excellence in Scientific Research on 1/20/2005 at the Annual Assembly of I “Symposium on Geriatric Education-Recruitment AAHPM and HPNA in New Orleans, LA. and Training” – Panel Discussion. Canadian I Geriatrics Society, Annual Scientific Meeting, Delta Meritorious Award from the Rhode Island Public Chelsea, Toronto. May 29th, 2004. Health Association Seventh Annual Meeting on 5/11/2004 for recognition of significant contribu- tions to the advancement of public health in Rhode Island at the federal, state, or local level. 71 geriatrics

Tom J. Wachtel, M.D. I RO1 AG024265(Teno) Feeding Tube Use Among I Member, Core Clerkship Committee Medical Persons with Advanced Dementia Journal Reviewer: I American Journal of Medicine TEACHING ACTIVITIES I Annals of Internal Medicine I Journal of General Internal Medicine TEACHING RESPONSIBILITIES I Journal of the American Geriatrics Society Richard W. Besdine, M.D. I Journal of the American Medical Association I Program Director, Geriatric Medicine Fellowship I New England Journal of Medicine Program I Field Experience Director, Geriatrics; Community RESEARCH AND OTHER Health Clerkship, Brown Medical Students SCHOLARLY ACTIVITIES I Preceptor, Geriatrics Rotation for Internal Medicine Residents FACULTY MEMBERS OF STUDY SECTIONS AND I Lecturer, B117 (Physiology) ADVISORY COMMITTEES David Michael Dosa, M.D., M.P.H. Richard W. Besdine, M.D. I Lecturer, Bio-Med Course 301, Introduction to I Consultant to HCFA Administrator on Geriatrics Clinical Medicine I Chief Scientific and clinical Officer, Rhode Island I Lecturer, Geriatric Fundamentals Lecture Series Quality Partners (PRO) I Preceptor, Geriatric Clinic, Geriatric Fellowship, I Chair, Ad Hoc Review Panel, National Institute on Intern Rotating Experience Aging, Loan Repayment Program I Medicine A Teaching Attending, Rhode Island Hospital Lynn McNicoll, M.D. I Teaching Attending: Geriatric Rounds. Rhode I Consultant, Hospital Quality Indicators, Rhode Island and Miriam Hospital. Island Quality Partners David R. Gifford, M.D. John B. Murphy, M.D. I Lecturer, “Geriatric Assessment” Clinical Diagnosis I 2003 - 2005Graduate Training in Family Medicine, course for second-year medical students at Brown HHS, Bureau of University I Health Professionals, HRSA, John B. Murphy (PI), I Co-Director, Geriatric Fellowship Curriculum in $352,556. Evidence-Based Medicine and Quality Joan M. Teno, M.D., M.S. Improvement, Brown University I MayDay Foundation Web Based Resources to Aide Lynn McNicoll, M.D., F.R.C.P.C. Nursing Homes in Improving Pain Management I Lecturer, Sexual Health Elective, Brown Medical I AG 023872 Teno Multifaceted Interventions to School Ameliorate Pain/Symptoms I Faculty Member, Geriatrics Fellowship Lecture I 1 R25 CA87972-01 (Abrams) Transdisciplinary Series: Delirium in Hospitalized Older Persons Cancer Control Research Training Grant Brown University I R01 CA097358 Cancer Assessments and Reports of I Preceptor, Geriatrics Rotation for Internal Medicine End-Of-Life Treatment Residents I The CASCADE Study: End-of-Life in Advanced Dementia John Murphy, M.D. I Advisor, Student Summer Research -N. I Improving Nursing Home Culture: Two-Pronged Herschenhaus - 2004 Pilot Special Study Brown University I Director, Geriatric Medicine Fellowship 2003 – 2005 I The National Quality Forum (NQF) Academic Partner to Support National Commission for I Director, Graduate Medical Education-Lifespan Quality Long Term Care 2004 – date 72 brown medical school department of medicine

Aman Nanda, M.D. Tom J. Wachtel, M.D. I Preceptor, Community Health Clerkship, Brown I Preceptor, Bio-Med Course 381, Community Medical School Health Clerkship, Brown University I Acting Program Director, Geriatric Medicine I Preceptor, Seminars in Epidemiology, Community Fellowship Program Nov. 2002- July 2003. Health Clerkship, Brown University I Preceptor, Geriatric Rotation for Internal Medicine I Course Director, Bio-Med Course 315F, Residents at RIH “Ambulatory Longitudinal Clerkship”,Brown University Joan M. Teno, M.D., M.S. I Director, Geriatric segment of Medicine Core I Course Director, Applied Health Service Research Clerkship, Brown University for Geriatric and Geropysch Fellows I Preceptor, Community-based Geriatric Practices I Precetor, Community Health Clerkship and Home Care Program, Rhode Island Hospital I Lecturer, Geriatric Fundamentals Lecture Series I Director and Preceptor, Required month-long geri- I Preceptor, Geriatric Clinic, Geriatric Fellowship, atrics rotation for internal medicine residents, Intern Rotating Experience Rhode Island Hospital I Teaching Attending: Geriatric Rounds. Rhode Island and Miriam Hospital.

GERIATRICS FELLOWSHIP PROGRAM

Departing Fellows Steven LaFond, MD, UCLA, San Diego, School of Medicine, San Diego,CA Howard Nachamie MD, SUNY-Brooklyn, NY; IM; Harvard Medical School and Hebrew Rehab Center, Boston Sourya Mahapatra, MD, Grant Medical College, Bombay, India, UMass Medical School, Western Campus, Berkshire Medical Center; Current Fellows

Michael Gerardo, D.O., Ohio University College of Osteopathic Medicine. Ramona Rhodes, M.D, University of Arkansas, Little Rock, AK, IM. Case Western Reserve, Cleveland, Ohio. Terri Spencer, M.D., Boston University School of Medicine, Boston, MA Rollin Wright, M.D., Albany Medical College, NY, IM (primary care, RIH) Brown U, Providence, RI

SELECTED PUBLICATIONS I Mor V., Angelelli J, Gifford D, Morris J, Moore T. Benchmarking and quality in residential and nursing David R. Gifford, M.D. homes: lessons from the US. Int J Geriatr Psychiatry. I Mor V, Berg K, Angelleli J, Gifford, DR, Morris J, 2003;18(3):258-66. Moore T. The Quality of Quality Measurement in US I Kissam S, Gifford DR, Parks P, Patry G, Palmer L, Nursing Homes. The Gerontologist. 2003; 43(2): 37-46. Wilkes L, Fitzgerald M, Petrulis A, Barnette L. I Mattke S, Reilly K, Martinez-Vidal E, McLean B, Approaches to quality improvement in nursing Gifford D. Reporting Quality of Nursing Home homes: Lessons learned from the six-state pilot of Care to Consumers: The Maryland Experience. CMS’s Nursing Home Quality Initiative BMC International Journal of Quality in Healthcare. Geriatrics 2003, 3:2 2003;13(2): 169-177.

73 geriatrics

Lynn McNicoll, M.D. Murphy JB. Aging in today’s world: Conversations I McNicoll L, Pisani M, Zhang Y, Ely EW, Siegel M, between an anthropologist and a physician. Medicine Inouye SK. Delirium in the Intensive Care Unit: Rhode Island. 2003;86:400. Occurrence and Clinical Course in Older Persons. J Am Geriatr Soc 2003;51(5):591-8. Aman Nanda, M.D. I Rhodes R, Nanda A. Images in medicine. Medicine I Pisani M, Inouye SK, McNicoll L, Redlich CA. and Health, Rhode Island. Journal by Rhode Island Screening for Pre-existing Cognitive Impairment in Medical Society. 2005;88(2):53. Older Intensive Care Unit Patients: Use of Proxy Assessments. J Am Geriatr Soc 2003;51(5):689-93. Joan Teno, M.D. I Pisani M, Redlich C, McNicoll L, Ely EW, Inouye I Baier RR, Gifford DR, Patry G, Banks SM, Rochon SK. Under-Recognition of Preexisting Cognitive T, DeSilva D, Teno JM. Ameliorating pain manage- Impairment by Physicians in Older Intensive Care ment in nursing homes: A collaborative quality Unit Patients Chest 2003;124(6:2267-74. improvement project. Journal of the American Geriatrics Society. December 2004; 52(12):1988-95. I Pisani M, McNicoll L, Inouye SK. Cognitive Impairment in the ICU. Clinics in Chest Medicine: I Mitchell SL, Teno JM, Miller SC, Mor V. A national Nonpulmonary critical care. Dec 2003;24(4):727-37. study of the location of death for older persons with dementia. Journal of the American Geriatrics John Murphy, M.D. Society. February 2005; 53(2):299-305. I Warshaw G, Murphy J, Buehler J, Singleton S. I Johnson VMP, Teno JM, Bourbonniere M, Mor V. Geriatric medicine training for family practice Palliative Care Needs of Cancer Patients in U.S. residents in the 21st century: A report from the Nursing Homes. Journal of Palliative Medicine. Residency Assistance Program/Hartford Geriatric April 2005; 8(2):273-79. Initiative. Family Medicine, 2003;35(1):24-29. I Teno JM, Rochon T. Rules to use and rules to lose I Warshaw GA, Murphy JB, Kahn NB, Hejduk GR, for pain management in the long-term care setting. Singleton SR. Geriatric medicine curriculum con- Medical and Health, Rhode Island. April 2005; sultations for family practice residency programs: 88(4):110-4. American Academy of Family Physicians residency I assistance program/Hartford Geriatrics Initiative. Connor SR, Teno J, Spence C, Smith N. Family JAGS 2003;51:858-862. Evaluation of Hospice Care: Results from Voluntary Submission of Data via Website. Journal of Pain and I Murphy JB, Rhodes R. Primary Prevention for Older Symptom Management. July 2005; 30(1):9-17 Persons. RI Medicine and Health. 2005;88:4-7. Listings are limited to the 5 most recent publications per I faculty member.

RESEARCH

Direct Indirect Total

Total Awards Recieved in Year 2003 $1,235,477 $404,351 $1,639,828

Total Awards Recieved in Year 2004 $505,654 $163,253 $668,907

Total Awards Recieved in Year 2005 $1,527,791 $517,177 $2,044,968

CLINICAL RESEARCH Robert Crausman, M.D. I Collaborative Program in Podogeriatrics, Health Richard Besdine, M.D. Resources & Services Administration I LTC Expert Advisory Panel, WV Medical Institute I RIQP Special Projects, RIQP Qualidigm 74 brown medical school department of medicine

HEMATOLOGY-ONCOLOGY OVERVIEW

The Brown University/Lifespan Hematology/Oncology group was formed when The Miriam Hospital Hematology/Oncology Division, the Rhode Island Hospital Division of Hematology and the Rhode Island Hospital Department of Medical Oncology merged in 1999. Our mission is to achieve academic excellence in basic research, clinical research and education, and to provide the highest quality of care to our patients. The creation of a Comprehensive Cancer Center, which is a collaborative effort to provide coordinated and comprehensive care for cancer patients at three Lifespan hospitals (The Miriam Hospital, Rhode Island Hospital and Newport Hospital), has now become a reality. Under the medical leadership of Dr. Fred Schiffman, state-of-the-art clinical cancer centers are now in operation at both The Miriam Hospital and Rhode Island Hospital There is a full complement of support services for our patients including the recent addition of a Nurse Navigator, who helps to guide the patient through their medical care. Edward Wittels, M.D., Associate Professor of Medicine; Interim Director of Hematology- Oncology and Interim Director of At Rhode Island Hospital there are four Medical Oncology Division at Brown Medical School Multidisciplinary Clinics: Melanoma, Breast, Upper GI studies of the cellular and molecular pathways leading and Neuro-oncology. In addition to the general Tumor to gastrointestinal cancer. The Center promotes basic Board where a variety of oncology cases are presented, research by supporting the research and career develop- there are three specialty Tumor Boards for malignancies ment of promising junior investigators and providing of the breast, chest, head, and neck. The Miriam state-of-the-art core facilities in proteomics and molec- Hospital participates in an off site Genitourinary ular biology. The administrative core of the group Multidisciplinary Clinic. There are two Tumor Boards organizes events including monthly research seminars, at The Miriam Hospital, one which includes all malig- an annual research symposium, and a public awareness nancies and the other which is a Thoracic Tumor Board. outreach event. It also organizes the meetings of its In the clinical area, three of our staff physicians includ- external advisory and internal executive committee, five ing Drs. Sundaresan Sambandam, Anthony Testa, and career development workshops, advisory meetings and Edward Wittels were included in the May 2004 Rhode peer review of grant applications for its investigators. Island Monthly magazine’s list of Top Doctors. Under the leadership of Dr. Alan Rosmarin, the Brown Since the last report, the Clinical Pharmacology University Oncology Group (BrUOG) continues its program at Rhode Island Hospital has joined the excellent work in developing and implementing cancer Division of Medical Oncology. This includes Drs. protocols. This along with our participation in national Devasis Chatterjee, James Darnowski, and Edward clinical cancer groups allows access for our patients to Filardo. Their research focuses on selected key molec- state-of-the-art cancer care. As an example, Dr. Gary ular events that govern cancer cell survival and death. Strauss was the Principal Investigator for the CALGB The Rhode Island Hospital COBRE Center for Cancer sponsored North American Intergroup Study evaluat- Research Development was established in 2002 under ing adjuvant chemotherapy in early stage non-small the leadership of Dr. Douglas Hixson, Director, and Dr. cell lung cancer. The positive results of this study have Nancy Thompson, Deputy Director. It’s mission is to changed the standard of care for these patients. The create, interpret and apply new knowledge based on cancer programs at Rhode Island Hospital and The original, collaborative, multidisciplinary laboratory Miriam Hospital were recently surveyed by the 75 hematology/oncology

Commission on Cancer of the American College of Surgeons and were once again awarded the maximum accreditation. Both Rhode Island Hospital and The Miriam Hospital have active Cancer Control Committees that oversee all cancer activities both in the hospital as well as in the community. There are representatives on this committee from the various disciplines of medical oncology, surgery and radiation oncology as well as from nursing, social work, commu- nity outreach, cancer data registry, pharmacy, nutrition services and pastoral care. The Brown University Hematology/Oncology Fellowship has successfully recruited outstanding fellows. Under the co-leadership of Drs. Alan Rosmarin and Anthony Mega the program has become among the most competitive in Alan Rosmarin, Associate Professor of Hematology-Oncology; New England. Each year we graduate between 3 and 5 Interim Director of Hematology Division and Director of fellows who have been recruited to both academic Brown University Oncology Group (BrUOG) medicine and private practice. Vanessa Johnson, M.D., Instructor (Research), Miriam Hospital FACULTY MEMBERS Djuro Josic, M.D., Professor (Research), Hematology/Oncology, Rhode Island Hospital FULL-TIME FACULTY (Hospital and Foundation Based) Anita Kestin, M.D., Clinical Assistant Professor, Edward Wittels, M.D., Interim Director, Hematology, Rhode Island Hospital, University Hematology/Oncology, Associate Professor, Miriam Medicine Foundation Hospital, University Medicine Foundation Yow Pin Lim, M.D., Ph.D., Assistant Professor Deborah Britt, Ph.D., Assistant Professor (Research), (Research), Oncology, Rhode Island Hospital Oncology, Rhode Island Hospital Leslie Lockridge, M.D., Assistant Professor, James Butera, M.D., Clinical Assistant Professor, Hematology/Oncology, Memorial Hospital Hematology, Rhode Island Hospital, University Anthony Mega, M.D., Assistant Professor (Clinical), Medicine Foundation Hematology, Miriam Hospital, University Medicine Devasis Chatterjee, Ph.D., Assistant Professor Foundation (Research), Oncology, Rhode Island Hospital Ahmed Nadeem, M.D., Assistant Professor, James Crowley, M.D., Professor, Hematology, Hematology/Oncology, Memorial Hospital Memorial Hospital Wolfgang Oster, M.D., Adjunct Professor, Oncology, James Darnowski, Ph.D., Associate Professor Rhode Island Hospital (Research), Oncology, Rhode Island Hospital Bai-Chuan Pan, Ph.D., Professor (Research), Karen Drumea, M.D., Instructor (Research), Oncology, Rhode Island Hospital Hematology, Rhode Island Hospital Neal Ready, M.D., Assistant Professor, Oncology, Rhode Loren Fast, Ph.D., Associate Professor (Research), Island Hospital, University Medicine Foundation Hematology, Rhode Island Hospital Alan Rosmarin, M.D., Associate Professor, Mary Anne Fenton, M.D., Clinical Instructor, Hematology/Oncology, Miriam Hospital, University Hematology, Rhode Island Hospital, University Medicine Foundation Medicine Foundation Howard Safran, M.D., Assistant Professor, Oncology, Edward Filardo, Ph.D., Assistant Professor (Research), Miriam Hospital, University Medicine Foundation Oncology, Rhode Island Hospital Fred Schiffman, M.D., Professor, Hematology, Michelle Haskell, Ph.D., Assistant Professor Miriam Hospital, University Medicine Foundation (Research) Rhode Island Hospital William Sikov, M.D., Clinical Assistant Professor, Douglas Hixson, Ph.D., Professor (Research), Oncology, Miriam Hospital, University Medicine 76 Oncology, Rhode Island Hospital Foundation brown medical school department of medicine

Gary Strauss, M.D., M.P.H., Brown faculty appointment A. Sattar Memon, M.D., Clinical Associate Professor, pending, Rhode Island Hospital, University Medicine Oncology, Memorial Hospital Foundation Peter Rintels, M.D., Clinical Assistant Professor, Rochelle Strenger, M.D., Clinical Assistant Professor, Hematology, Rhode Island Hospital Hematology/Oncology, Miriam Hospital, University Sundaresan Sambandam, M.D., Clinical Assistant Medicine Foundation Professor, Oncology, Rhode Island Hospital Nancy Thompson, Ph.D., Professor (Research), Anthony Testa, M.D., Clinical Instructor, Oncology, Oncology, Rhode Island Hospital St. Joseph’s Hospital VOLUNTEER FACULTY Kathy Theall, M.D., Clinical Instructor, Hematology/Oncology, Memorial Hospital Kwang Ahn, M.D., Clinical Assistant Professor, Oncology, Roger Williams Medical Center Anthony Thomas, D.O., Clinical Assistant Professor, Hematology, Rhode Island Hospital Joseph DiBenedetto, Jr., M.D., Clinical Assistant Professor, Hematology/Oncology, Rhode Island Fred Vohr, M.D., Clinical Assistant Professor, Hospital Hematology/Oncology, Rhode Island Hospital Nancy Freeman, M.D., Clinical Associate Professor, Francis Cummings, M.D., Adjunct Associate Hematology, VA Medical Center Professor, Oncology, Roger Williams Medical Center Linda Hassan, M.D., Clinical Assistant Professor, A. Raymond Frackelton, Ph.D., Adjunct Associate Hematology, Memorial Hospital Professor, Oncology, Roger Williams Medical Center Peter Hoffmann, M.D., Clinical Assistant Professor, Seth Rudnick, M.D., Adjunct Associate Professor, Hematology, Miriam Hospital Oncology, Rhode Island Hospital Plakyil Joseph, M.D., Clinical Assistant Professor, Philip Schein, M.D., Adjunct Professor, Oncology, Oncology, Roger Williams Medical Center Rhode Island Hospital Lawrence Lum, M.D., Adjunct Professor, Hematology, Alan Weitberg, M.D., Adjunct Professor, Oncology, Roger Williams Medical Center Roger Williams Medical Center

FACULTY TRANSITIONS

Departing Faculty

Kwang Ahn, M.D., Clinical Assistant Professor, Roger Williams Medical Center A. Raymond Frackleton, Ph.D., Adjunct Associate Professor, Roger Williams Medical Center Michelle Haskell, Ph.D., Assistant Professor (Research), Rhode Island Hospital Vanessa Johnson, M.D., Instructor (Research), Miriam Hospital Wolfgang Oster, Adjunct Professor, Rhode Island Hospital Bai-Chuan Pan, Ph.D., Professor (Research), Rhode Island Hospital Seth Rudnick, M.D., Adjunct Associate Professor, Rhode Island Hospital Philip Schein, M.D. Adjunct Professor, Rhode Island Hospital New Faculty Devasis Chatterjee, Ph.D., Assistant Professor (Research), Rhode Island Hospital Leslie Cousens, Ph.D., Instructor (Research), Rhode Island Hospital James Darnowski, Ph.D., Associate Professor (Research), Rhode Island Hospital Karen Drumea, M.D., Instructor (Research), Rhode Island Hospital Edward Filardo, Ph.D., Assistant Professor (Research), Rhode Island Hospital Djuro Josic, M.D., Professor (Research), Rhode Island Hospital Lawrence Lum, M.D., Adjunct Professor, Roger Williams Medical Center Wolfgang Oster, M.D., Adjunct Professor, Rhode Island Hospital Bai-Chuan Pan, Ph.D., Professor (Research), Rhode Island Hospital 77 hematology/oncology

NATIONAL AND INTERNATIONAL I Breast Cancer Research & Treatment HONORS AND RECOGNITION I Cancer Research OF FACULTY I FASEB I Journal of Steroid Biochemistry & Molecular Biology Deborah Britt, Ph.D. I Trends in Endocrinology & Metabolism Invited presentations: Endocrinology I “Tight Junctions in Tumor Development,” I European Journal of Biochemistry Providence College, 2004. Invited presentations: Devasis Chatterjee, Ph.D. I “Engagement of integrin aVb1 is required for I Member, American Association for Cancer research estrogen-dependent transactivation of the EGFR in Invited presentations: breast cancer cells”,International Congress on I “Stat3, a caspase target during CD95-triggered Hormonal Steroids and Hormones and Cancer apoptosis”,American Association for Cancer Douglas Hixson, PhD Research 94th Annual Meeting, July 2003. I Chair, COBRE CCRD Symposium. “Molecular Events James W. Darnowski, Ph.D. in Gastrointestinal Disease.” Providence, RI. July 2003. I Member, CET-3 Study Section, Department of I Co-Chair, COBRE CCRE Mini-Symposium. Defense Breast Cancer Research Program Ad hoc “Translation Research in Cancer.” Providence, RI. reviewer: November 2003. I Cancer Research I Co-Chair ASIP Symposium. “Controversies in Stem I Biochemical Pharmacology Cell Research, Experimental Biology.” Washington, D.C. 2004. I Molecular Pharmacology I Chair, COBRE CCRD Symposium. Providence, RI. I Cancer June 2004. I Oncology Research I Chair, COBRE CCRD Symposium. “Cancer Research: I Journal of the National Cancer Institute The Lighthouse of Hope.” Providence, RI. June 2005. I Leukemia Research Anita Kestin, M.D. I Journal of Clinical Oncology Invited presentations: I Canadian National Cancer Institute I “Coagulation Disorders” at University of Rhode Invited presentations: Island, Kingston, RI I “STAT proteins are a target of caspase-mediated I “An Ethical Dilemma” at New England Regional cleavage during staurosporin-induced apoptosis in Hemophilia Center, Worcester, MA the DU145 human prostate tumor cell model”, I Annual Meeting of the American Association Yow Pin Lim, M.D., PhD forCancer Research, July 2003. Invited presentations: I “Inter-alpha Inhibitors in Inflammation and Loren Fast, PhD Cancer Development of Diagnostics and Invited presentations: Therapeutics” at COBRE Translational Research I “Inactivation of white blood cell function by Mirasol Symposium, Providence, RI. November 2003. PRT treatment” at Navigant Biotechnologies, Inc, I “Preparative Cleavage of Proteins on Immobilized Lakewood, CO. Enzyme CIM® Disk” at First Summer School on Mary Anne Fenton, M.D. Monoliths for Biochromatography, Bioconversion Invited presentations: and Solid Phase Synthesis. Portoroz, Slovenia, June I “Pathophysiology of Breast, Cervical and Endometrial 6-9, 2004. Cancers” at University of Rhode Island, Kingston, RI. Anthony, Mega, M.D. Edward J. Filardo, Ph.D. Invited presentations: I Career Development Award, Department of Defense I “New Treatment Options for Non-Hodgkin’s I Consultant, Proctor and Gamble Pharmaceuticals Lymphoma at Symposium, Providence, RI, March, 78 Ad hoc reviewer: 2004. brown medical school department of medicine

I “Tomato Paste, Selenium and Finasteride – A I “GA-Binding Protein (GABP) is required for Recipe for Prostate Cancer Prevention?” at myeloid gene transcription and cellular develop- American College of Physicians meeting, Warwick, ment; Hoofbeats in Africa: the Brown RI, May 2004. University/Moi Medical Exchange Program” at I “The Expanding Role of Hormonal Therapy for Louisiana State University, Shreveport/Feist-Weill Prostate Cancer” at Grand Rounds, Cancer Center, Shreveport, LA. March 2005. Hematology/Oncology Update, Rhode Island I “GABP (GA Binding Protein) is required for Hospital, Providence, RI, February 2005. Myeloid Cell Development” at Sixth International Meeting on Myeloid Stem Cell Development and Neal Ready, M.D., Ph.D. Leukemia, Annapolis, MD. May 2005. Invited presentations: I “GA-Binding Protein (GABP): a key regulator of I “Treatment of Stage III NSCLC” at Oncology myeloid gene transcription is required for cell cycle Grand Rounds, The Cancer Center at New England progression” at Mt. Sinai School of Medicine, New Medical Center, September 2003. York, NY. June 2005. I “ZD1839 (NSC#a75055, IND#61187) with induc- tion Paclitaxel and Carboplatin followed by either Fred Schiffman, M.D. radiation or concomitant radiation with weekly Invited Presentations: Paclitaxel and Carboplatin in Stage III Non-small I “Continued Evolution of the Brown Cell Lung Cancer, A Phase II Study” at NCI CSTEP University/Lifespan Comprehensive Cancer Center; Early Drug Development Meeting, Bethesda, MD, Schwartz Rounds; Defining Competence for Faculty September 2004. Reappointment” – Chiefs of Medicine Meeting, I “Lung: Medical Oncology” at SIR Annual Scientific Naples, Florida. Meeting, Interventional Radiology, New Orleans, I “Advocating for Residents Applying to Fellowships” LA, March 2005. at Association of Program Directors in Internal I “Current Medical Therapy for the Treatment of Medicine, San Francisco, California. Lung Cancer” at SIR Annual Scientific Meeting, I “T-cell lymphoma presenting as fevers and lactic Interventional Radiology, New Orleans, LA, April acidosis” at American College of Physicians 2005. Meeting. Committees: William Sikov, M.D. I Chairman, Thoracic Committee, Brown University Invited presentations: Oncology Group I “Advances in the Treatment of Metastatic Breast I Member, CALGB Respiratory Committee Cancer” at Regional Oncology Center, SUNY Upstate Member, NCI Lung Intergroup Committee, Limited Medical University, Syracuse, NY, August 2003. Stage SCLS Working Group I “Breast Cancer Update: Review of the 2004 San Antonio Breast Cancer Symposium” at University Alan Rosmarin, M.D. of Vermont, Manchester, VT, March 2005. Invited presentations: I Co-organizer and speaker at Fifth Workshop on Gary Strauss, M.D., MPH Stem Cells and Myeloid Cell Development, San I Principal Investigator: CALGB-sponsored North Diego, CA. December 2003. American Intergroup Study evaluating the use of I “GA-Binding Protein (GABP): a key regulator of adjuvant chemotherapy in T2-N0, Stage I non- myeloid gene transcription is required for cell cycle small cell lung cancer. progression” at Yale University Hematology I Organizer and Scientific Secretary of the “Como Seminar, New Haven, CT. October 2004. International Conference – Lung Cancer Screening I Co-organizer and speaker at Sixth Workshop on for Early Diagnosis, Como, Italy, November 2003. Stem Cells and Myeloid Cell Development, San Invited presentations: Diego, CA. December 2004. I “Chest X-ray Screening for Lung Cancer: Its Time I “GA Binding Protein (GABP): a key regulator of Has Come” at Society of Medical Decision myeloid gene transcription is required for cell cycle Makings, Chicago, IL, October 2003. progression” at University of Massachusetts, Department of Cell Biology. January 2005. 79 hematology/oncology

I “CT Screening for Lung Cancer: Evaluation of Del Polmone: Per Medici Specilaisti in Formazione: Previous Trials: Implications for the Future” at Lettura Magtistrale: Policlinico Gemelli, Universita American College of Surgeons 89th Annual Clinical Cattolica di Roma, Rome, Italy, October 2004. Congress, Chicago, IL, October 2003. I “Randomized Clinical Trial of Adjuvant I “Epidemiology of Pleural Mesothelioma: Worldwide Chemotherapy with Paclitaxel and Carboplatin in Trends” at International Conference on Pleural Stage IB Non-Small Cell Lung Cancer (NSCLC): Mesothelioma, Como, Italy, November 2003. Report of CALGB Protocol 9633” at European I “Aftermath of the 1998 Varese Conference: A New Society of Medical Oncology (ESMP), Vienna, Scenario for Lung Cancer Screening” at Austria, November 2004. International Conference on Lung Cancer Screening I “Adjuvant Chemotherapy of Lung Cancer: for Early Diagnosis: Five Years After the 1998 Varese Methodologic Issues and Clinical Advances” at City Conference, Como, Ital, November 2003. of Hope National Medical Center, Duarte, CA, I “Screening for Lung Cancer: Its Time Has Come” at November 2004. International Conference on Lung Cancer Screening I “Current Perspectives in the Treatment of Early for Early Diagnosis: Five Years After the 1998 Varese Stage Lung Cancer” at Kansai Clinical Oncology Conference, Como, Italy, November 2003. Group and West Japan Thoracic Oncology Group I “Epidemiology of Malignant Pleural in Osaka, Japan, in Okayama, Japan, in Sapporo, Mesothelioma” at Universitaire Ziekenhuizen Japan, in Fukuoka, Japan, March 2005. Leuven, Symposium on Malignant Mesothelioma, I “Adjuvant Chemotherapy in Non-Small Cell Lung Leuven, Belgium, November 2003. Cancer” at Seventh Annual Palm Beach Cancer I “Randomized Clinical Trial of Adjuvant Symposium – Combined Modality Therapy of Chemotherapy with Paclitaxel and Carboplatin in Common Malignancies, Palm Beach, FL, April 2005. Stage IB Non-Small Cell Lung Cancer (NSCLC): Rochelle Strenger, M.D. Report of Cancer and Leukemia Group B (CALGB) Invited presentations: Protocol 9633” at American Society of Clinical I “Breast Cancer Prevention, Diagnosis & Treatment Oncology Annual Meeting, New Orleans, LA, June Options” at Lifespan’s Breast Cancer Awareness 2004. Program, Warwick, RI, October 2003. I “Adjuvant and Neoadjuvant Chemotherapy in I “Breast and Cervical Cancer” at Lifespan Resectable Lung Cancer” at Japanese Lung Cancer Community Health Program, Providence, RI, April Workshop, American Society of Clinical Oncology 2004. Annual Meeting, New Orleans, LA, June 2004. I “Breast Cancer Diagnosis and Treatment” at I “Randomized Clinical Trial of Adjuvant Lifespan’s Women’s Wellness Workshop, Warwick, Chemotherapy with Paclitaxel and Carboplatin in RI, March 2005. Stage IB Non-Small Cell Lung Cancer (NSCLC): Report of CALGB Protocol 9633” at Cancer and Nancy Thompson, PhD Leukemia Group B Plenary Presentation, Invited presentations: Philadelphia, PA, July 2004. I “Oncofetal and Amino Acid-Responsive hepatic I “Randomized Clinical Trial of Adjuvant LAT1/CD98 Expression” at International Society of Chemotherapy with Paclitaxel and Carboplatin in Differentiation Meeting, Lyon, France Stage IB Non-Small Cell Lung Cancer (NSCLC): I “Mentoring and Minority Recruiting in Report of CALGB Protocol 9633” at Central Pathobiology” at American Society for Investigative European Lung Cancer Conference, Gdansk, Pathology Graduate Program Director’s Workshop, Poland, September 2004. San Diego, CA I “Adjuvant Chemotherapy for Lung Cancer: New Perspectives” at Diagnosi Precoce e Nuove Strategie di Trattamento Del Cancro Del Polmone, University of Insubria, Varese, Italy, September 2004. I “Advances in Adjuvant Chemotherapy Following Resection in Early Stage Lung Cancer” at Il Cancro 80 brown medical school department of medicine

RESEARCH AND OTHER SCHOLARLY Howard Safran, M.D. ACTIVITIES I Chairman, Gastrointestinal Oncology Committee, Radiation Therapy Oncology Group (RTOG) FACULTY MEMBERS OF STUDY SECTIONS AND I Ad Hoc Member, Study Section, “Rapid Access to ADVISORY COMMITTEES Intervention Development;” Medical Oncology I Chairman, RTOG national protocol, “A Phase II Devasis Chatterjee, Ph.D. Trial of External Irradiation and Weekly Paclitaxel I Assisted Andrea Bianchi-Sartore, M.D., clinical for Non-Metastatic Unresectable Pancreatic Cancer” research Fellow, with his research on the I Medical Oncology Chairman, RTOG/Intergroup “Regulation of apoptosis in human colon and national protocol, “A Phase III Study of Pre and mesothelioma cells by RKIP” Post Chemoradiation 5-FU vs. Gemcitabine for James W. Darnowski, Ph.D. Postoperative Adjuvant Treatment of I Faculty Leader, International Medical Fellow ResectedPancreatic Adenocarcinoma” Research Group 2002-2004 Andrea Sartore-Bianchi I Medical Oncology Chairman, RTOG national I Mentor & Research Advisor, Arshad Asnudian, protocol, “Phase II Study of Paclitaxel, Gemcitabine M.D., Candidate for MS/MD Degree, Brown and Radiation Followed by the Farnesl Transferase Medical School -1997-Present Summer student Inhibitor R115777 for Locally Advanced Pancreatic mentor 2005 Edward Richards 2004 Elin Simms Cancer” I Medical Oncology Liaison to Translation Research Edward J. Filardo, Ph.D. Program, RTOG I Research Mentor, 2001-2003 Jeffrey A. Quinn, MS I Medical Oncology Chairman for upcoming RTOG Mary Anne Fenton, MD protocol testing a ras peptide vaccine with chemora- I Fellow, American College of Physicians, 2005 diation as adjuvant therapy for pancreatic cancer

Douglas Hixson, PhD Anthony Mega, M.D. I Member, NIEHS study section, Review of Toxico- I Chairman, Genitourinary Subcommittee, Brown Genomics Consortium Member Applications University Oncology Group I Member, Scientific Review Board, Brown University Neal Ready, M.D., PhD Oncology Group I Study section: Chair, Cancer and Leukemia Group B Protocol #30106: “ZD-1839 (NSC# 715055) with Fred Schiffman, M.D. Induction Paclitaxel and Carboplatin followed by I Co-Chairperson, Committee on Clinical either Radiation or Concomitant Radiation with Appointments and Promotions, Brown University Weekly Paclitaxel and Carboplatin in Stage III Department of Medicine Nonsmall Cell Lung Cancer, a Phase II Study” I Chairperson, Chiefs of Medicine of Federation of Alan Rosmarin, M.D. Jewish Philanthropies Hospitals I Chair, Leukemia, Immunology, and Blood Cell I Governor, American College of Development Study Section, American Cancer Physicians/American Society of Internal Medicine Society I Brown University Department of Medicine I Member, Subcommittee C, National Cancer Preceptorship Award, 1998-2005 Institute, NIH. I Brown University Profiles of Competence Award: I Member, Myeloid committee, American Society of Effective Communication, 2004 Hematology. I Marshall, Brown Medical School Commencement I Member Council for Extramural Grants, American Exercises. Cancer Society. Nancy Thompson, PhD I Member, Editorial Board, Stem Cells. I Intramural Advisory Committee, RIH Trauma and I Member, Editorial Board, Cancer Information Inflammation Training Grant (PI J. Albina) Database, American Cancer Society. I National Advisory Board, FASEB Minority Access I Co-organizer, Workshop on Myeloid Development. to Research Careers (MARC) Program 81 hematology/oncology

I Reviewer for National Medical Research Council, I Dean’s Teaching Excellence Award, BioMed 350: Singapore Pathophysiology – Hematology, Brown Medical I Chair, Federation of American Societies for School Experimental biology (FASEB) Excellence in I Preceptorship Award – Brown Medical School, Science Award Committee Rhode Island Hospital, The Miriam Hospital I Chair, American Society for Investigative Pathology I Department of Medicine Chairman’s Award for Career Development Workshop “Pathways to Outstanding Teaching – Brown Medical School Leadership”: “Leadership Styles, Flavors and Colors,” San Diego, CA. Alan Rosmarin, M.D. I Dean’s Teaching Excellence Award, BioMed 350: Pathophysiology – Hematology, Brown Medical TEACHING ACTIVITIES School

EDUCATION HONORS Fred Schiffman, M.D. I Dean’s Teaching Excellence Award, BioMed 350: James Butera, M.D. Pathophysiology – Hematology, Brown Medical I Dean’s Teaching Excellence Award, BioMed 350: School Pathophysiology – Hematology, Brown University Edward Wittels, M.D. Anita Kestin, M.D. I Dean’s Teaching Excellence Award, BioMed 350: I Dean’s Teaching Excellence Award, Brown University Pathophysiology – Hematology, Brown Medical School Anthony, Mega, M.D.

HEMATOLOGY/ONCOLOGY FELLOWSHIP PROGRAM Graduates 2004 Fellow Medical School Residency Program Post-fellowship Position Debra Holik, MD New York Medical College Brown University – Private practice Valhalla, NY The Miriam & Plymouth, MA Rhode Island Hospitals Providence, RI Katrina Rolen, MD St Louis University St. Louis University Health Private practice School of Medicine Sciences Center Idaho St. Louis, MO St. Louis MO Amanda Sun, Sun Yat-sen University of Yale University, Academic medicine MD, PhD Medical Sciences Norwalk Hospital Shreveport, LA Guangzhou, P.R.China Norwalk, CT James Tsai, MD St. George’s University UMDNY – New Jersey Private practice St. George’s, Granada Medical School Hemet, CA Newark NJ George Zahrah, MD University of Ancona Yale University, Private practice Ancona, Italy Danbury Hospital Norwalk, CT Danbury, CT

82 brown medical school department of medicine

Graduates 2005 Fellow Medical School Residency Program Post-fellowship Position Douglas Brandoff, MD Mt. Sinai School of Lahey Clinic Fellowship Medicine Burlington, VT Massachusetts New York, NY General Hospital Boston, MA Bharti Chauhan, MD Pandit JJM Medical Brown University, Memorial Private practice College Hospital of RI Roger Williams Raipur, India Pawtucket, RI Medical Center Providence, RI Samir Desai, MD Northeastern Ohio Summa Health System Private practice Universities of Medicine Akron, OH Portland, Oregon Rootstown, OH Ronald Harris, DO Lake Erie College of Temple University, Conemaugh Private practice Osteopathic Medicine Valley Memorial Hospital Binghamton, NY Erie, PA Johnstown, PA Linda Ries, MD University of Vermont Brown University – Private practice Burlington, VT Rhode Island Hospital Montana Providence, RI 2003-2004

Fellow Medical School Residency Program J. Mark Barnett, MD Southern Illinois University Brown University Springfield, IL Rhode Island Hospital The Miriam Hospital, Providence, RI Ariel Birnbaum, MD Medical College of Ohio University of Minnesota Toledo, OH Minneapolis, MN Kurt Demel, MD University of Cincinnati Health Alliance of Greater Cincinnati, OH Cincinnati, OH Ursula Reusch, MD University of Missouri Brown University Columbia, MO Rhode Island Hospital -The Miriam Hospital, Providence, RI

2004-2005

Fellow Medical School Residency Program David Benton, MD University of Connecticut Brown University Farmington, CT Rhode Island Hospital -The Miriam Hospital, Providence, RI Devon Evans, MD Jefferson Medical College Beth Israel Deaconess Philadelphia, PA Medical Center Boston, MA Diane Paggioli, DO University of New England Center Roger Williams Medical Biddeford, ME Providence, RI Tirrell Johnson, MD University of Florida Orlando Regional Medical Gainesville, FL Center, Orlando, FL Neil Zakai, MD University of Virginia University of Vermont Charlottesville, VA Burlington, VT

83 hematology/oncology

SELECTED PUBLICATIONS James Darnowski, Ph.D. I Allegrini, G, Goulette, FA, Darnowski, JW and Deborah Britt, Ph.D. Calabresi, P. Thrombospondin-1 plus irinotecan: a I Britt, D.E., Yang, D.F., Yang, D.Q., Flanagan, D., novel antiangiogenic-chemotherapeutic combina- Callanan, H., Lim, Y.P., Lin, S.H., Hixson, D.C. tion that inhibits the growth of advanced human Identification of a Novel Protein, LYRIC, Localized colon tumor xenografts in mice. Cancer Chemother to Tight Junctions of Polarized Epithelial Cells. Exp Pharmacol 2004; 53:261-6. Cell Res 2004; 300:134-48. I Darnowski, J.W., Goulette. F.A., Cousens, L.P., I Comegys, M.M., Lin, S.H., Rand, D., Britt, D., Chatterjee, D. and Calabresi, P. Mechanisitc and Flanagan, D., Callanan, H., Hixson, D.C. Two antineopastic evaluation of Taurolodine in the Vaiable Regions in Rat and Human CEACAM1 N- DU145 model of human prostate cancer. Cancer terminal Domains Located in or Proximal to Chemother Pharmacol 2004; 54, 249-58. Monoclonal Antibody and Adhesion Epitopes Show I Cousens, L.P., Goulette, F.A., Calabresi, P. and Evidence of Recombination in Rat but not in Darnowski, J.W. JAK-mediated signaling inhibits Human. J Biol Chem 2004; 279:35063-78. Fas ligand-induced apoptosis independent of de novo protein synthesis. J Immunol 2005; 174:320-7. James Butera, M.D. I Yango A, Morrissey P, Monaco A, Butera J, et al. Loren Fast, Ph.D. Successful treatment of tacrolimus-associated I Fast, L., J. Semple, G. DiLeone, M Kim, J thrombotic microangiopathy with sirolimus con- Freedman, J Chapman, and A Purmal. Inhibition version and plasma exchange. Clin Nephrol 2002 of xenogeneic graft-versus-host disease by Jul; 58(1):77-8. INACTINETM PEN110 treatment of donor human peripheral blood mononuclear cells. Transfusion Devasis Chatterjee, Ph.D. 2004; 44:282-5. I Chatterjee, D., Roy, R., Braastad, C., Mott, S., Sun, Y., Mukhopadhay, A., Aggarwal, B., Darnowski, J., Mary Anne Fenton, M.D. Pantazis, P., Wyche, J.H., Sedivy, J.M. and Yeung, K. I Pinto, BM, Trunzo, JJ, Rabin, C, Cady, B, Fenton, RKIP sensitizes prostate and breast cancer cells to MA, Herman, A, Legare, R., and Sikov, W. drug-induced apoptosis. J Biol Chem 2004; 279, Recruitment Strategies for a Home-Based Physical 17515-23. Activity Intervention for Breast Cancer Patients. J I Chatterjee, D., Goldman, M., Braastad, C., Clin Psych In Med Settings 2004 Sept; Vol. 11, No. 3. Darnowski, J., Wyche, J.H., Pantazis, P. and I Ries, LM, Fenton, MA, Dizon, DS, Gass, JS, Graves, Goodglick, L. The role of 14-3-3? expression in TA, Strenger, RS, Sikov, WM. Brown University resistance of prostate cancer cells to 9-nitrocamp- Oncology Group; Rhode Island Hospital, Prov, RI; tothecin. Int J Oncol 2004; 25, 503-9. Women and Infants Hospital, Prov, RI; The Miriam I Odabaei, G., Chatterjee, D., Jazirehi, A.R., Hospital and Women and Infants Hospital, Prov, RI. Goodglick, L., Yeung, K. and Bonavida, B. Raf-1 Neoadjuvant q4week carboplatin and weekly paclitax- Kinase Inhibitor Protein (RKIP): Structure, el + trastuzamab in resectable and locally advanced Function, regulation of cell signaling and pivotal breast cancer: A Brown University Oncology Group role in apoptosis. Ad. Cancer Res 2004; 91, 169-200. (BrUOG) study. 2005 ASCO Annual Meeting Proceedings, Supplement to J Clin Oncol; Vol. 23, No. I Jazirehi, A.R., Chatterjee, D., Odabaei, G., Vega, 16S, Part I of II, abstr. #759, June 1, 2005. M.I., Goodglick, L. and Bonavida, B. Rituximab triggers RKIP expression and inhibits MAPKs I Sikov, WM, Theall, KP, Seidler, CW, Strenger, RS, ERK1/2 and AP-1 activation in non-Hodgkins Fenton, MA, Brown University Oncology Group; The Lymphoma B-cells: Role in down-regulation of Bcl- Miriam Hospital, Prov, RI; Memorial Hospital of xL expression. Cancer Res 2004; 64:7117-26. Rhode Island, Prov, RI; The Fallon Clinic, Worcester, MA; Rhode Island Hospital, Prov, RI. Gemcitabine I Yuan, P. Z., Guan, A. Y., Chatterjee D., and Chin, and capecitabinein metastatic breast cancer (MBC): Y.E. Reversible acetylation of a single lysine residue A Brown University Oncology Group (BrUOG) within the C-terminal region of STAT3 regulates phase II study. 2005 ASCO Annual Meeting STAT3 dimerization. Science 2005; 307: 269-73. Proceedings, Supplement to J Clin Oncol: Vol. 23, No. 84 16S, Part I of II, abstr. #785, June 1, 2005. brown medical school department of medicine

Edward Filardo, Ph.D. I Ready N, Aronson F, Wanebo H, Kennedy T. A low I Thomas, P, Pang, Y, and Filardo, EJ, Identity of a rate of central nervous system (CNS) progression membrane estrogen receptor coupled to a G-protein in in a phase II trial of outpatient chemobiologic ther- human breast cancer. Endocrinol 2005; 146: 624-32. apy with cisplatin, temozolomide, interleukin-2 (IL-2) and interferon alfa 2-B (IFN) for metastatic Yow-Pin Lim, M.D., Ph.D. malignant melanoma. Accepted for publication Am I Baek YW, Brokat S, Padbury JF, Pinar H, Hixson J Clin Oncol 2005 Feb. DC, Lim YP. Inter-alpha inhibitor proteins in I Rathore R, Chougule P, Wanebo H, Theall K, Ruhl infants and decreased levels in neonatoal sepsis. J C, Nadeem A, Koness J, Oldenburg N, Kennedy T, Pediatr 2003 Jul; 143(1):11-5. Ready N; Roger Williams Med Ctr, Providence, RI; I Lim YP, Bendelja K, Opal SM, Siryaporn E, Hixson Rhode Island Hosp, Providence, RI; Memorial DC, Palardy JE. Correlation between mortality and Hosp of Ri, Pawtucket, RI; Brown Univ Oncology the levels of inter-alpha inhibitors in the plasma of Group, Providence, RI. ASCO Proceedings 2005 patients with severe sepsis. J Infect Dis 2003 Sep 15; June; 23, Abstr 5556:514s. 188(6):919-26. Epub 2003 Aug 26. I Wu R, Cui X, Lim Y-P, Bendelja K, Zhou M, Simms Alan Rosmarin, M.D. H, Wang P. Delayed administration of human inter- I Bush TS, St. Coeur M, Resendes KK, Rosmarin AG. alpha inhibitor proteins reduces mortality in sepsis. GA binding protein (GABP) and Sp1 are required, Crit Care Med 2004 Aug; 32(8):1747-52. along with retinoid receptors to mediate retinoic acid responsiveness of CD18 (ß2 leukocyte integrin): I Lim Y-P, Josic D, Callanan H, Brown J, Hixson DC. a novel mechanism of transcriptional regulation in Affinity purification and enzymatic cleavage of myeloid cells. Blood 2003; 101:311-7. inter-alpha inhibitor proteins using antibody and elastase immobilized on CIM monolithic disks. J I Rosmarin AG, Resendes KK, Yang Z, Mcmillan J, Chromatography A 2005; 1065:39-43. Fleming SL. GA binding protein (GABP) transcrip- tion factor: a review – GABP as an integrator of intra- I Opal SM, Artenstein AW, Cristofaro PA, Jhung JW, cellular signaling and protein-protein interactions. Palardy JE, Prejo NA, Lim Y-P. Inter-alpha inhibitor Blood Cells, Molecules, and Diseases 2004; 32:143-54. proteins are endogenous furin inhibitors and pro- vide protection against experimental anthrax intox- I Resendes KK, Rosmarin AG. Sp1 control of gene ication. Infect Immun 2005 Aug; 73(8):5101-5. expression in myeloid cells. Critical Reviews in Eukaryotic Gene Expression 2004; 14:171-81. Anthony Mega, M.D. I Rosmarin AG, Yang Z, Resendes KK. Transcriptional I Barnett JM, Demel KC, Mega AE, Butera JN, Regulation in myelopoiesis: hematopoietic fate Sweeney JD. Lack of bleeding in patients with choice, myeloid differentiation, and leukemogenesis. severe factor VII deficiency. Am J Hematol 2005 Experimental Hem 2005; 33:131-43. Feb; 78(2):134-7. Howard Safran, M.D. Neal Ready, M.D., Ph.D. I Safran H, DiPetrillo T, Nadeem A, Steinhoff M, I Ready N, Herndon J, Vokes E, Bogart J, Crawford J, Tantravahi U, Rathore R, Wanebo H, Hughes M, DiPetrillo T, Green M. Initial cohort toxicity evalu- Maia C, Tsai JY, Pasquariello T, Pepperell JR, Cioffi W, ation for chemoradiotherapy (CRT) and ZD 1839 Kennedy T, Reeder L, Ng T, Adrian A, Goldstein L, in stage III non-small cell lung cancer (NSCLC): a Chak B, Choy H. Trastuzumab, paclitaxel, cisplatin, CALGB stratified phase II trial. ASCO Proceedings and radiation for adenocarcinoma of the esophagus: 2004 June; 22:635s. a phase I study. Cancer Invest 2004; 22(5):670-7. I Nadeem A, Desai S, Chougule P,Wanebo H, Ruhl C, I Safran H, Iannitti D, Ramanathan R, Schwartz JD, Joyce D, Tarro J, Kennedy T, Ready N.Decreased dis- Steinhoff M, Nauman C, Hesketh P, Rathore R, Wolff tant recurrence and preserved local control using R, Tantravahi U, Hughes TM, Maia C, Pasquariello T, dose dense induction weekly paclitaxel (P), and car- Goldsteiin L, King T, Tsai JY, Kennedy T. Herceptin boplatin © followed by concurrent paclitaxel, carbo- and gemcitabine for metastatic pancreatic cancers platin and radiotherapy (CRT) in locally advanced that overexpress HER-2/neu. Cancer Invest 2004; head and neck squamous cell cancers (HN-SCC). 22(5):706-12. ASCO Proceedings 2004 June; 22, Abstr 5545:499s. 85 hematology/oncology

Fred Schiffman, M.D. I Strauss GM, Babbitt DG, Dominioni L. Island-Lake I Tuohy K, Nicholson W, Schiffman FJ. Agitation by model of carcinogenesis: implications for randomiza- sedation. Lancet 2003; 361:308. tion, survival, and mortality in randomized popula- tion trials of cancer screening. Lung Cancer (Abstracts Strauss, Gary, M.D., M.P.H. of the 11th World Conference on Lung Cancer) 2005; I Strauss GM. Adjuvant chemotherapy of lung cancer: 49:(Supplement 2) S187 (Abstract P-275). methodologic issues and therapeutic advances. Hematol Oncol Clin North Am 2005 Apr; 19(2):263- Nancy Thompson, Ph.D. 81, vi. Review I Padbury JF, McGonnigal B, Miller C, Fugere C, I Strauss GM, Dominioni L, Jett JR, Freedman M, Kuzniar M and Thompson NL. Transcriptional reg- Grannis FW Jr. Como international conference ulation Of the LAT-1/CD98 light chain. Biochem position statement: lung cancer screening for early Biophys Res Comm 2004; 318:529-34. diagnosis 5 years after the 1998 Varese conference. I Storey BT, Fugere C, Lesieur-Brooks A, Vaslet C and Chest 2005 Apr; 127 (4):1146-51. Review. Thompson NL. Adenoviral modulation of the I Strauss GM, Babbitt DG. The Mayo lung project tumor-associated system L amino acid transporter, and non-small cell lung cancer: does overdiagnosis LAT1, alters amino acid transport, cell growth and explain improved survival? 2005 American Society 4F2/CD98 expression in cultured hepatic cells. Int J of Clinical Oncology (ASCO) Meeting Proceedings, Cancer 2005; 117 (Epub May, 2005). Supplement to J Clin Oncol 2005; 23:665S (Abstract Listings are limited to the 5 most recent publications per 7181). faculty member. I Strauss GM, Babbitt DG, Dominioni L. Was over- diagnosis responsible for spurious survival advan- tages in randomized trials of lung cancer screening? – Public policy implications. Lung Cancer (Abstracts of the 11th World Conference on Lung Cancer) 2005; 49:(Supplement 2) S20-S21 (Abstract O-051).

RESEARCH

Direct Indirect Total

Total Basic Research Expenses for Academic Year 2003 $2,423,099 $653,952 $3,078,051 Clinical Hematology Medical Oncology Academic Year 2004 $2,104,365 $727,933 $2,832,298

Total Clinical Research Expenses for Academic Year 2003 $705,506 $148,459 $853,515 Clinical Hematology Medical Oncology Academic Year 2004 $513,173 $94,522 $607,695

BASIC RESEARCH Davasis Chatterjee, I The Evaluation of Novel Camptothecin Analogs in Deborah Britt, Ph.D. Camptothecin - Resistant DU 145 Human Prostate I Examination of a Novel Protein, LYRIC, and its Cancer Cells. Sigma-Tau Pharmaceuticals Inc. Involvement in Prostate Tumor Suppression James Darnowski, Ph.D. Mediated by the Cell Adhesion Molecule CEACAM1. I Development of Novel Therapies for Human Department of Defense Prostate Cancer. T.J. Martell Foundation I The Role of a Novel Protein, LYRIC in I T.J. Martell - Administrative (Scientific Advisory Development of Hepatocellular Carcinoma. Committee). T. J. Martell Foundation Inc. Lifespan (COBRE Pilot Project) Loren Fast, Ph.D. I The Effect of INACTINE on Lymphocyte Response. 86 V. I. Technologies, Incorporated (VITEX) brown medical school department of medicine

I Immunological Consequences of Transfusion. Nancy Thompson, Ph.D. National Heart Lung & Blood Institute I Amino Acid Regulated Gene Expression in I Modeling Immune Responses to PUVA Treated Tumorigenesis. American Institute for Cancer Clonal T cell Populations. Therakos Research I I Studies on the Effect of Riboflavin + Light Expression & Role of TA1, Oncofetal Gene in Liver Treatment on In Vitro and In Vivo Immune Cancer. NIH/National Cancer Institute Responses of Human Peripheral Blood Non- nuclear Cells. Navigant CLINICAL RESEARCH Edward Filardo, Ph.D. I Estrogen Signaling Via GPR30. American Cancer James Butera, M.D. Society I Phase III Study of STI571 vs. Interferon-a Combined with Cytarabine in Patients with Newly I Evaluating of GPR30, a Novel Estrogen Receptor Diagnosed Previously Untreated Philadelphia for Assessing Responsiveness to Anti-estrogen Chromosome Positive Chronic Myelogenous Therapy. US Department of Defense-Army Leukemia in Chronic Phase-CML-CP. Novartis Douglas Hixson, Ph.D. Pharmaceuticals Corporation I Center for Cancer Research Development (COBRE) I Phase III Study of ST1571 vs. Interferon-a Proteomics. National Center for Research Resources Combined with Cytarabine in Patients with Newly I Center for Cancer Research Development (COBRE) Diagnosed. Novartis Pharmaceuticals Corporation Administrative. National Center for Research Mary Anne Fenton, M.D. Resources I A Phase II Trial of Novel Epothilone BMS-247550 in I Molecular Determinants of Multi-cellular Patients with Advanced Breast Cancer Who are Organization. National Cancer Institute Resistant to an Anthracycline, A Taxane and I Cellular Origins of Liver Cancer. National Cancer Capecitabine 9CA163-081. Bristol-Myers Squibb, Inc. Institute Anthony Mega, M.D. I Genesis of Liver Carcinomas with Oval Cell Traits. I Therion Prostate: Safety and Efficacy of PROST- National Cancer Institute VAC-VF/TRICOM in Combination with GM-CSF. I FACTOR VIII. Octapharma Pharmaceutical Therion Biologics Corporation Erica Lawson I LS-P-RE-107 Interleukin-2 in an Alternative Dose I The Effects of CEACAM1b-4S on Tumorigenicity. (The ILIAD Trial) Treatment of Patients with National Cancer Institute Metastatic Renal Cell Carcinoma with Low-Dose Proleukin. Chiron Corporation Yow-Pin Lim, M.D., Ph.D. I BrUOG NHL-83 (Eli Lilly) A Phase I Study of I Therapeutic and Prognostic Application of Human Escalating Doses of Gemcitabine Combined with Plasma Inter/Alpha Inhibitor in the Management of Standard CHOP Chemotherapy with G-CSF Support Se. The Slater Center for Biomedical Technology (G-CHOP-G) in Patients with Intermediate/high I Inter-alpha Inhibitors in Neonatal Sepsis. National Grade or Mantle Cell NHL. Eli Lilly and Company Institute for Child Health and Development I BrUOG NHL-83 (Amgen) A Phase I Study of I Immunoregulatory Role of Granzyme in Sepsis. Escalating Doses of Gemcitabine Combined with Lifespan Standard CHOP Chemotherapy with G-CSF Support (G-CHOP-G) in Patients with Intermediate/high Alan Rosmarin, M.D. Grade or Mantle Cell NHL. Amgen I Center for Genetics and Genomics. National Institutes of Health/Brown I BrUOG Pros-90 A Phase I/II Study of Taxol, Carboplatin and Colchicine (TCC) in Androgen I The New Stem Cell Biology, COBRE. Roger Independent Prostate Cancer. Bristol Myers Squibb Williams Medical Center/NIH

87 hematology/oncology

I PROS 307, A Phase II Randomized, Double Blind, I A Two-Part, Multiple Dose Clinical Trial of Safety Controlled Study to Evaluate the Safety and and Efficacy of ABX-EGF in Combination with Efficacy of PROSTVAC-VF/TRICOM in Paclitaxel and Carboplatin in Patients with Combination with GM-CSF in Patients with Advanced NSCLC (LU303). Amgen, Inc. Androgen-Independent Adenocarcinoma of the I A Phase 3 Randomized Study of Lonafarnib in Prostate (TBC-PRO-002). Therion Pharmaceuticals Combination with Paclitaxel and Carboplatin vs. Placebo in Combination with Paclitaxel and Neal Ready, M.D. Carboplatin in Patients with Non-Small Cell Lung I BrUOG ESO-78 A Phase I/II Trial of Herceptin, Cancer. Schering-Plough Corporation Paclitaxel, Cisplatin and Radiation Followed by Maintenance Herceptin for Adenocarcinomas of I SP-P00370 A Phase I Multi-center Study of the Esophagus. Brown University/Genentech Continuous Oral Administration of SCH 66336 and IV Paclitaxel in Patients with Advanced Cancer. I A Phase I/II Study of Estramustine, Docetaxel and Schering-Plough Corporation Ifosfamide with Carboplatin in recurrent or Metastatic Head and Neck Squamous Cell Cancers I Sunbelt Melanoma Trial: A Multi-center Trial of (HN-SCC). Aventis Pharmaceuticals Products, Inc. Adjuvant Interferon Alfa-2B for Melanoma Patients with Early Lymph Node Metastasis Detected by I A Phase I Multi-center Study of Continuous Oral Lymphactic Mapping and Sentinel Lymph Node Administration of SCH 66336 and IV Paclitaxel in Biopsy. Schering-Plough Corporation Patients with NSCLC. Schering-Plough Research Institute I A Multi-center, Open Label Randomized Study of Three Schedules of Weekly Taxol Induction Therapy I A Phase III Randomized Trial of Active Followed by Weekly Taxol Maintenance Therapy in Immunotherapy with a Polyvalent Melanoma Vaccine Metastatic Breast Cancer Patients. Theradex (C-VAX) versus Biotherapy with Interferon x-2b as a Post-Surgical Treatment for Stage III Melanoma I BrUOG H & N 86 Induction Chemotherapy with (BrUOG Mel A-118). Brown University/Wayne Weekly Taxol, Ifosfamide, and Carboplatin Followed by Concurrent Weekly Taxol and I Brown University Oncology Group (BrUOG) Carboplatin and Radiotherapy in Locally Advanced Protocols. Brown University/Bristol Myers Head and Neck Cancers. Bristol-Myers Squibb, Inc. I Topotecan for Relapsed Small Cell Lung Cancer. I A Phase III Randomized Trial of Active SUNY Syracuse/GlaxoSmith Kline Immunotherapy with a Polyvalent Melanoma I BrUOG-NSCL-99 Neoadjuvant Carboplatin with Vaccine (C-VAX) Versus Biotherapy with Interferon Weekly Paclitaxel in Resectable Non-small Cell x-2b as a Post-Surgical Treatment for Stage III Lung Cancer: A Phase II Study. Bristol-Myers Melanoma. Brown University/NCI/John Wayne Squibb, Inc. Cancer Institute I BrUOG Hn 204, Concurrent Chemoradiotherapy I Outpatient Concurrent Chemo-Biotherapy for with Cetuximab for Stage III and IV Locally Metastatic Malignant Melanoma Phase II. Chiron Advanced Squamous Cell Carcinoma of the Head Corporation and Neck-A Phase II Trial. Bristol-Myers Squibb, Inc. I Outpatient Concurrent Chemo-Biotherapy for I A Randomized, Partially Blinded, Phase II Study to Metastatic Malignant Melanoma, Phase II. Schering Assess the Safety, Tolerability and Efficacy of Corporation ZD6474 Alone or in Combination with Paclitaxel I The SILVA Study: Survival in International Phase and Carboplatin in Subjects with Previously III Prospective Randomized LD Small Cell Lung Untreated Locally Advanced or Metastatic NSCLC. Cancer Vaccination Study with Adjuvant BEC2 and AstraZeneca BCG. Imclone Systems Incorporated I Sigma-Tau- ST 01-401 Phase I Study of Oral St I BrUOG Mel-A-119: A Phase III Randomized, 1481 Administered Once Weekly Every 3 out of 4 Double-blind, Trial of Immunotherapy with Weeks in Patients with Advanced Solid Polyvalent Melanoma Vaccine (C-VAX) plus BCG Malignancies. Sigma-Tau Pharmaceuticals Inc. vs. Placebo Plus BCG as a Post-Surgical Treatment I Randomized Study of Docetaxel Versus Docetaxel for Stage IV Melanoma. John Wayne Cancer Plus Genasense in Patients with Previously Treated Institute/Brown 88 Non-Small Cell Lung Cancer. Genta Incorporated brown medical school department of medicine

Alan Rosmarin, M.D. I Phase I Trial of Tarceva, Gemcitabine, Paclitaxel I An Open-label, Randomized Study to Develop a and Radiation for Locally Advanced Pancreatic Screening Tool for Functional Capacity in Anemic Cancer. Genentech, Inc. Subjects with Nonmyeloid Malignancies Receiving I BrUOG EG-103 A Phase I/II Trial of Oxaliplatin, Chemotherapy with Darbepoetin also (NESP). Taxotere and Capecitibine in Advanced CA of the Amgen Esophagus and Stomach. Sanofi-Synthelabo I BrUOG MDS-85 Phase I/II Study of ONTAK in the I Safety and Efficacy of Oral Gimatecan Treatment of Myelodysplastic Syndromes. Brown Administered on a dx4 Schedule every 28 Days as University Second line Therapy for Metastatic Colorectal I BrUOG ESO-78 A Phase I/II Trial of Herceptin, Cancer in Patients without Previous to Paclitaxel, Cisplatin and Radiation Followed by Camptothecins, a Phase II Trial. Sigma-Tau Maintenance Herceptin for Adenocarcinomas of Pharmaceuticals Inc. the Esophagus. Brown University/Genentech I BrUOG EG 203 Cetuximab, Paclitaxel, Carboplatin and Radiation for Esophageal, Gastroesophageal Howard Safran, M.D. Junction and Gastric Cancer. Bristol-Myers Squibb, I Ls-P-PA103 Randomized Phase II Trial to Evaluate Inc. the Effect of Gemcitabine Plus R115777 Versus Gemcitabine Plus Placebo on Time to I A Double blind, Placebo Controlled, Minimized Deterioration in Patients with Advanced Pancreatic Phase III Study Comparing Marimastat to Placebo Cancer (R115777-INT-16). PRA/Janssen as Adjuvant Therapy in Patients with Respectable Pancreatic Cancer. Brown University I A Phase II Study to Determine the Antitumor Activity of Farnesyltransferase Inhibitor R115777 in I An Open Label Phase I Study to Evaluate the Safety Subjects with Relapse Small Cell Lung Cancer. and Tolerability of rV-CEA(6D)/TRICOM Jannsen Pharmaceuticals/Brown University Admixed with rV-MUC-1, followed by rF- CEA(6D)/TRICOM in Combination with GM-CSF I Radiation Therapy Oncology Group. Brown in Subjects with Unresectable Adenocarcinoma of University/NIH the Pancreas. Orion Clinical Services Inc./Therion I BrUOG MEL-69 Outpatient, Concurrent Chemo- I A Phase II Study of Neoadjuvant Bevaciizumab, Biotherapy (Cisplatin, Temozolomide, Interleukin-2 Oxaliplatin, 5-FU and Radiation in Clinical Stage and Interferon Alpha-2b) for Metastic Malignant II-III Rectal Cancer. Genentech, Inc. Melanoma, Phase II. Brown University/Integrated I LS-P-GA101 “A Phase II Study of Epothilone I Herceptin and Gemcitabine for Metastatic Analog BMS-247550 in patients with Metastatic Pancreatic Cancers that Over Express Her2/NEU Gastric Adenocarcinoma Previously Treated with a (Genentech). Genentech, Inc. Taxane. Bristol-Myers Squibb, Inc. I BrUOG PA-77 Herceptin and Gemicitabine for I BrUOG PA 205 A Phase I Trial of GW572016, Metastic Pancreatic Cancers that Over Express Gemcitabine and Oxaliplatin for Metastatic HER-2/neu. Brown University Pancreaticobiliary Cancer. GlaxoSmithKline I BrUOG PA-77 Phase II Study of Herceptin and I BrUOG ES-88 Phase I/II Trial of Capecitabine, Gemcitabine for Metastatic Pancreatic Cancers that Taxotere, and Carboplatin in Metastatic Over Express HER-2/Neu. Lilly Research/Brown Adenocarcinoma of the Esophagus and Stomach. University Roche Laboratories I A Phase I Study of Hepatic Arterial Infusion of I LS-P-PA-109 A Randomized, Open-Label, Multi- Oxaliplatin in Advanced Hepatocellular Carcinoma. center Phase III Study Comparing the Efficacy and Roger Williams Hospital Safety of a Combination of Intravenous DX-8951F I A Phase I Trial of CT-2103, Cisplatin and Radiation (exatecan mesylate) plus Gemcitabine to for Esophageal and Gastric Cancer. Cell Gemcitabine Alone in Patients with Locally Advanced Therapeutics, Inc. or Metastatic Cancer. Daiidhi Pharmaceutical I Phase I/II Study of Capecitabine/Taxotere and I Percutaneous Radiofrequency Ablation of Bone Carboplatin in Metastatic Adenocarcinoma of the Metastases Using CT Guidance. Radionics Esophagus and Stomach. Aventis Pharmaceuticals Instruments/Brown University Products, Inc. 89 hematology/oncology

I BrUOG EG 103 A Phase I/II Trial of Oxaliplatin, I BrUOG-BR-95 Weekly Paclitaxel and q 4 week Taxotere and Capecitibine in Advanced CA of the Carboplatin (+/- herceptin) as Neoadjuvant Esophagus and Stomach. Roche Laboratories Therapy in Resectble and Unresectable (stage IIA- IIIB) Breast Cancer. Genentech, Inc. William Sikov, M.D. I Gemcitabine and Capectibine in Advanced Breast I CALGB Foundation Grant. University of Chicago Cancer: A BrUOG Phase II Study. Brown/Lilly I CALGB Main Member Support Program. Research Laboratories University of Chicago/NCI I A Randomized, Open Label, Multi-center Study of I CALGB-Surgery. University of Chicago/NCI Primary Prophylaxis with Neulasta Versus I A Multi-center, Open-label, Randomized, Two-arm Secondary Prophylaxis as and Adjunct to Study of Irinotecan (CPT-11) versus the Chemotherapy in Elderly Subjects with Cancer. Combination of Oxaliplatin and Irinotecan (CPT- Amgen, Inc. 11) as Second Line Treatment of Metastatic I An Open Label Randomized Phase III Study of Colorectal Carcinoma. Sanofi-Synthelabo Intermittent Oral Capecitabine in Combination I A Phase II Study of Glutamine Supplementation in with I.V. Oxaliplatin (q3w) (Xelox) vs. Bolus and Patients Receiving Weekly Taxol for Metastic Breast Continuous Infusion 5FU, I>V> Leucovorin on Non-Small Cell Lung Cancers. Boston w/Oxalilplatin (q2w) (Folfox4) as First Treatment University/Bristol-Myers for Patients w/Locally. Roche Laboratories I A0. Randomized Multi-center, Phase II Study of I Gemcitabine and Capectibine in Advanced Breast Bolus/Infusion 5FU/LV vs Oxaliplatin and Bolus Cancer: A BrUOG Phase II Study. Lilly Infusion 5-FU/LV as Third-Line Treatment of Research/Brown University Patients with Metastatic Colorectal Carcinoma EFC I Gemcitabine and Capecitabine in Advanced Breast 4760, Prologue Research International, Inc./Sanofi Cancer: A BrUOG Phase II Study. Roche I BrUOG-BR-95 Weekly Paclitaxel and q 4 week Laboratories Carboplatin (+/- Herceptin) as Neoadjuvant I Multi-center Phase II Study of Herceptin and Therapy in Resectable and Unresectable (stage IIA- Navelbine as First-Line Therapy for HER2-Postive, IIIB) Breast Cancer. Bristol-Myers Squibb, Inc. Metastatic Breast Cancer. Dana Farber Cancer I BMS CA 163-012-010 A Phase II Study of Institute/Glaxo Epothelone Analog BMS-247550 in Patients with I Cancer and Leukemia Group B Foundation. Cancer Metastatic Colorectal Cancer Previously Treated and Leukemia Group B Foundation/U. Chicago with a Fluorphyrimidie and Irinotecan. Bristol- Myers Squibb, Inc. Rochelle Strenger, M.D. I I LS-P-CO104 A Multi-center, Open-Label, NSABP Breast Cancer Prevention Trial. Dana Randomized, Two-Arm Study of Irinotecan (CPT- Farber Cancer Institute/NCI 11) versus the Combination of Oxaliplatin + Irinotecan (CPT-11) as Second-Line Treatment of Metastatic Colorectal Carcinoma (SR96669, EFC 4585). Sanofi-Synthelabo

90 brown medical school department of medicine

HOSPITALIST MEDICINE OVERVIEW

hode Island’s first inpatient group inaugurated on August 7, 1996. This was a ground breaking Rmove especially given the fact that the term ‘hospitalist’ had not yet been coined. The program,. originally under the Division of General Internal Medicine, began modestly with three full time physi- cians. Initially, the role of the inpatient group was to cultivate relationships with community physicians and a marketing campaign was launched. A patient brochure was designed to provide an explanation to patients about the new Internal Medicine Inpatient Service (hereby designated as IMIS). Physicians were invited to sign up with this new program that provided inpatient care to their patients giving them the advantage of remaining in their offices as opposed to making a hospital visit. The IMIS program established formal links with the patients Primary Care Physicians. Communication was established at the time of admission and discharge via fax or phone call; discharge summaries sent once available. Over time the momentum of the hospitalist movement began to gain significant ground. Many outpatient practitioners realized that hospital medical practice Sajeev Handa, MD, Director, Division of was becoming an increasingly complex endeavor: Hospitalist Medicine managing a sicker inpatient load; ordering and the Division of Hospitalist Medicine was created. following up on tests; interacting with consultants and so forth. The result was that demand for the The Division of Hospitalist Medicine is now responsible inpatient group grew and in October 1999 the program for the following clinical programs at Rhode Island was further expanded and two additional physicians Hospital: were added to complement the existing three. During The Hospitalist Program – offering admissions, man- this year all other non-teaching services at Rhode agement through until discharge for primary care Island Hospital (which had existed as separate entities) physicians who have signed up with the group; were folded into the IMIS program including the The Community Physician Alliance Service –staffed nurse practitioner service as well as the House Officer by primarily nurse practitioners – this program offers on Private Service (HOOPs) program. cross coverage services on all medical non-teaching The IMIS program functioned in this capacity services during the weekdays and assistance with through until July 2003 when further alterations were admissions overnight. made on account of the reduced workload for The Division of Hospitalist Medicine currently housestaff mandated by the ACGME (Accreditation employs the equivalent of nine full time University Council for Graduate Medical Education). Staffing Medicine Foundation Physicians as well as four nurse was increased to accommodate a new chest pain practitioners. All physicians hold clinical appointments observation service as well as increased outpatient with Brown Medical School. physician enrollment to the hospitalist program. In the summer of 2003 Rhode Island Hospital’s Jane Teaching responsibilities with the Medical School Brown 2 North ward was designated an IMIS unit in have included the second year history and physical order to streamline admissions and discharges. In course as well as preceptorship for the third year September 2003 another milestone was achieved and medical students. 91 hospitalist medicine

FACULTY MEMBERS Jacqueline Michaud, DO I Member, Federal Disaster Medical Assistant Team FULL-TIME FACULTY(Hospital and Foundation Based) (Homeland Security) Sajeev Handa, M.D., Clinical Instructor, Rhode Island I Member, American College of Physicians Hospital, University Medicine Foundation. Lina R. Nemchenok, MD Kim A. Basu, M.D., Clinical Instructor, Rhode Island I Member, Massachusetts Medical Society Hospital, University Medicine Foundation. I Member, Society of Hospital Medicine Sheenagh M. Bodkin, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation. Joel T. Park, MD I Member, American College of Physicians Walid Farah, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation. I Member, American College of Pediatricians Saira Hussain, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation. SELECTED PUBLICATIONS Husam Issa, M.D., Clinical Instructor, Rhode Island Hospital. University Medicine Foundation. Joel T. Park. MD Jaqueline Michaud, D.O., Clinical Instructor, Rhode I Park, J.T. Padbury, J, Maternal Grave’s Disease and Island Hospital. University Medicine Foundation. Neonatal Hyperthyroidism Presenting as pseudo- “TORCH” Syndrome in a Premature Newborn. Mariana Murea, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation. I Park, J.T., Hennessey. Two-week low iodine diet is necessary for adequate outpatient preparation for Lina R. Nemchenok, M.D., Clinical Instructor, Rhode 121-I Thyrogen scanning in patients taking levothy- Island Hospital, University Medicine Foundation. roxine, Thyroid 14(1): 57-63, 2004. Joel T. Park, M.D., Clinical Instructor, Rhode Island Listings are limited to the 5 most recent publications per Hospital, University Medicine Foundation. faculty member.

NATIONAL AND INTERNATIONAL HONORS AND RECOGNITION OF FACULTY

Kim A. Basu MD I Member, Society of Hospital Medicine I Member, Massachusetts Medical Society

Walid Farah, MD I Member, American College of Physicians I Member, Society of Hospital Medicine

Sajeev Handa, MD I Charter Member, Society of Hospital Medicine I Member, Infectious Diseases Society of America I Member, Northeast Regional Council, Society of Hospital Medicine. I Reviewer, Journal of Acquired Immune Deficiency Syndrome

92 brown medical school department of medicine

INFECTIOUS DISEASE OVERVIEW

he Division has continued to grow and develop new initiatives in the area of HIV and AIDS, Tbioterrorism, treatment of sepsis, and inpatient infectious diseases. The NIH funded Lifespan/Tufts/Brown Center for AIDS Research, under the leadership of Dr. Charles Carpenter, continues to support laboratory and clinical HIV prevention and treatment research. The total external HIV/AIDS research funding, from all sources, for Brown University faculty, exceeds $10,000,000 per annum. The NIH Center grant strongly supports the primary thematic goal of the Lifespan/Tufts/Brown CFAR, which is to carry out translational research which deals especially with the treatment and prevention of HIV infection in hard-to- reach populations, both in New England and in several countries in the developing world. The NIH Fopgarty HIV Training Program (AIETRP) supports interna- tional clinicians and scholars who receive further HIV related training at Brown and affiliated hospitals. The AIDS Clinical Trials Unit (ACTU) at The Miriam Hospital/Brown University, under the leadership of Timothy P. Flanigan, M.D., Professor of Medicine; Director, Dr. Karen Tashima and Dr. Timothy P. Flanigan, has Division of Infectious Disease been an outstanding success. This is one of 30 units around the country which is NIH funded to partici- well as two Special Projects of National Significance pate in multi-center HIV and AIDS treatmenttrials. funded through the Ryan White Care Act. Infectious The Miriam Hospital/Brown University has played a disease physicians with a focus on HIV and AIDS leading role in the development and enrollment of provide care not only in the hospital setting, but also HIV treatment trials, specifically for women. Dr. Susan at the state prison, substance abuse treatment centers, Cu-Uvin has been elected as Vice Chair of the and community health centers in the surrounding Women’s Group of the AIDS Clinical Trials Group towns of Woonsocket, Fall River, and Newport. The (ACTG). Her RO1, in its 7th year, investigates HIV overlap between HIV, Hepatitis C and addiction has led shedding and resistance in the genital tract. We have to integrated models of care and prevention. Under the been chosen as one of six sites to develop a new inter- leadership of Dr. Rich, the Center for Prisoner Health national treatment initiative for HIV and AIDS as part and Human Rights has been established to promote of the ACTG. We have developed a multi-center treat- diagnosis and treatment of infectious diseases within ment protocol which will be implemented in Chennai, the correctional settings nationwide. A NIH funded India with our collaborative partners at YRG Care. T32 training grant supports faculty and fellows who HIV vaccine trials under the leadership of Dr. Michelle focus on infectious diseases among communities that Lally are investigating adenovirus vector HIV vaccines suffer disproportionately from addiction. for both immunogenicity and safety. The new Center for Biodefense and Emerging Pathogens A priority for the Division of Infectious Diseases has at Memorial Hospital directed by Dr. Andy Artenstein been innovative models for improved prevention, continues its successful role both within Brown and diagnosis, and treatment of HIV, particularly in the within Rhode Island. Dr. Artenstein, along with the clinical setting. Support has generously been provided Center’s Associate Director, Dr. Peggie Neill has provided through Ryan White Titles II, III, and IV programs, as substantial community based education around biode- fense since 9/11 to a variety of medical and public safety 93 infectious disease

personnel. The Center has been awarded a substantial role in defining improved strategies to prevent nosoco- contract from the Rhode Island Department of Health mial infections, particularly related to intravascular for which it has developed educational tools for the catheters. Intravascular catheter infections are a major health care community, as well as for the broader public, cause of morbidity among inpatients. Dr. Leonard A. and the Center’s physicians provide 24/7 consultative Mermel has spearheaded efforts to better define and services for the RI DOH for bioterrorism concerns. institute strategies aimed at prevention of such Under the leadership of Dr. Artenstein, Memorial infections. He was the senior author of the Infectious Hospital will participate in Phase I/II trials to evaluate Diseases Society of America guidelines on Management the safety and efficacy of new more effective smallpox of Intravascular Catheter-Related Infections and Dr. vaccines. Dr. Peggie Neill chairs the Bioterrorism Mermel co-authored national guidelines from the WorkGroup for the Infectious Disease Society of Centers for Disease Control on the Prevention of America, which has played a leading role in education of Intravascular Catheter-Related Infections. Dr. Mermel Infectious Disease physicians since 9/11. As part of that is the 25th President of the Society for Healthcare effort, she has spearheaded the development and main- Epidemiology of America, a society whose members are tenance of the IDSA web site on bioterrorism, develop- infection control opinion leaders from over 30 countries. ing authorita tive materials, including clinical pathways, In addition, Dr. Mermel is an invited Technical Expert for evaluation of disease syndromes, with full text access Panel Member of the Medicare Patient Safety Task to the references and citations supporting the content. Force for the US Dept. of Health & Human Services. The IDSA group is expanding its scope to include bio- This committee guides the Centers for Medicare & emergencies and is now incorporating materials on pan- Medicaid Services in determining patient safety outcome demic and avian influenza into the web site. indicators for hospitalized elderly patients. The Vaccine Study Unit at CBEP has completed mul- The Division of Infectious Diseases has established a tiple Phase II and Phase III clinical trials of advanced new consultative service to prevent and treat infections generation smallpox vaccines and is currently work- among solid organ transplant recipients As the number ing on novel vaccine approaches to this virus. of kidney and pancreas transplants performed at RIH Additionally, NIH-funded research in the laboratories has increased, the Division has responded by providing of Dr. Andrew Artenstein and Dr. Steven Opal has inpatient and outpatient consultative services for this focused on novel approaches to treat and prevent vulnerable patient population, led by Staci Fischer, M.D. anthrax; to date, several compounds have shown The Division of Infectious, in conjunction with promise in small animal models, and collaboration Pulmonary and Critical Care Medicine, have established with USAMRIID at Fort Detrick, MD. is underway to the Ocean State Clinical Coordinating Center (OSCC)] study these approaches in spore challenges in larger at Rhode Island Hospital. Steven P. LaRosa, MD serves mammals. Dr. Neill was asked to chair the Bioterrorism as the Director of the OSCCC and Steven Opal, MD Working Group for the Infectious Disease Society of serves as Associate Director. The OSCCC is an academic America, which has played a leading role in education group of physicians, research nurses, and research assis- of Infectious Disease physicians since 9/11. tants who, working in conjunction with a study sponsor, The Rhode Island State Tuberculosis Treatment serve as the “real-time” main point of contact for study Program moved to The Miriam Hospital, Brown sites for a variety of services. These services include: University School of Medicine. This has been a nation- assessment of patient eligibility for the study, direction ally recognized program of excellence which was cited regarding protocol procedures, and answering questions by the Centers for Disease Control for its leadership regarding concomitant medications and safety concerns. nationwide in establishing directly observed therapy The OSCCC secured a grant from Chiron Corporation programs for all persons with TB. This program has in April 2004 to be the clinical coordinating center for a participated in national trials to improve TB therapy. worldwide, randomized. placebo-controlled, Phase III Dr. Jane Carter has established a outstanding collabora- trial of rTFPI in severe community acquired pneumonia tion with Moi University Medical School in Eldoret, (CAPTIVATE Study). Kenya, which will investigate improved TB therapeutic Dr. Ken Mayer has recently received multiple awards for strategies for patients who have TB alone and for those his outstanding work in the area of HIV prevention. He patients who are co-infected with HIV and TB in the was honored by the American Federation for AIDS developing world, which poses unique challenges. Research to receive its yearly award for leadership in the 94 The Division of Infectious Diseases has played a lead area of HIV clinical research. He was chosen as the Paul brown medical school department of medicine

Galkin Lecturer for Distinguished Leadership in HIV FACULTY MEMBERS and AIDS. He also received honorary lifetime member- ship in the Indian Medical Association due to the estab- FULL-TIME FACULTY (Hospital and Foundation Based) lishment of the HIV/AIDS prevention and treatment Timothy P. Flanigan, M.D., Director, Professor, collaboration with YRG Care in Chennai, India. Dr. Miriam Hospital, University Medicine Foundation Mayer leads the HIV Prevention Trials Network pro- gram at The Miriam Hospital/Brown University, which Andrew W. Artenstein, M.D., Associate Professor, has played a leading role in developing and evaluating Memorial Hospital of RI microbicides for the prevention of HIV, both in this Charles C. J. Carpenter, M.D., Professor, country and in resource poor settings. Miriam Hospital, University Medicine Foundation Dr. Timothy P. Flanigan and Dr. Jennifer A. Mitty have Curt Beckwith, M.D., Assistant Professor of Medicine, spearheaded a program of modified directly observed Miriam Hospital therapy for HIV treatment for individuals who are Ruth I. Connor, Ph.D., Assistant Professor (Research) marginalized and would otherwise not receive the Rhode Island Hospital benefit of our new combination HIV treatments. A Patricia A. Cristofaro, M.D. Assistant Professor pilot program for active substance abusers to provide (Research), Miriam Hospital community based treatment strategies is ongoing and *E. Jane Carter, M.D., Assistant Professor, has been cited nationally. This work has been presented Miriam Hospital, University Medicine Foundation at the Infectious Disease Society of America, the Conference on New Advances in HIV Therapies spon- *Susan Cu-Uvin, M.D., Associate Professor, sored by the American Federation for AIDS Research, Miriam Hospital, University Medicine Foundation and the National Retroviral Conference, and has Staci A. Fischer, M.D., Assistant Professor, Rhode received funding through an RO1 from the National Island Hospital, University Medicine Foundation Institutes of Health. Pilot programs to extend these Mary M. Flynn, Ph.D., R.D., L.D.N., Assistant community based therapies for pregnant women and Professor (Research), Miriam Hospital persons leaving prison have begun. Melissa M. Gaitanis, M.D., Assistant Professor, Rhode Bharat Ramratnam, M.D. directs the Virology Core Island Hospital, University Medicine Foundation laboratory at Brown for the Center for AIDS Stephen H. Gregory, Ph.D., Associate Professor Research. His work investigates viral dynamics, and (Research), Rhode Island Hospital particularly viral decay among individuals who are Joseph I. Harwell, M.D., Assistant Professor, Miriam long-term injection drug users. He has received fund- Hospital, University Medicine Foundation ing from the Doris Duke Foundation, NIH/ NIAID, and the Culpepper Foundation. Rami Kantor, M.D., Assistant Professor (Research), Rhode Island Hospital INTERNATIONAL WORK Awewura Kwara, M.D., Assistant Professor, Miriam Jane Carter, who is a national expert on TB, oversees Hospital, University Medicine Foundation opportunities for clinical research for residents in Africa Michelle A. Lally, M.D., Assistant Professor, Miriam (Moi Medical School, Kenya). Drs. Mayer, Flanigan and Hospital, University Medicine Foundation Cu-Uvin collaborate on HIV clinical research in Jerome M. Larkin, M.D., Assistant Professor of Medicine, Chennai, India, Cambodia, Philippines and Indonesia Rhode Island Hospital, University Medicine Foundation related to HIV prevention and treatment of AIDS and Steven P. LaRosa, M.D., Assistant Professor, Rhode opportunistic infections. Herb Harwell, M.D., who was Island Hospital, University Medicine Foundation trained in both Pediatrics and Medicine, has expertise in the area of sexually transmitted diseases and HIV. He John R. Lonks, M.D., Associate Professor, has developed ongoing projects in Phnom Penh, Miriam Hospital, University Medicine Foundation Cambodia to evaluate the long-term morbidity and *Mark Lurie, Ph.D., Assistant Professor, mortality related to HIV and the potential impact of Miriam Hospital antiretroviral therapy in Southeast Asia. Kenneth H. Mayer, M.D., Professor, Miriam Hospital, University Medicine Foundation

95 infectious disease

Troy Martin, M.D., Assistant Professor of Medicine, ADJUNCT FACULTY Memorial Hospital of Rhode Island Seth F. Berkley, M.D., Adjunct Associate Professor, Antone A. Medeiros, M.D., Professor, Miriam Miriam Hospital Hospital, University Medicine Foundation Susan E. Cook, Ph.D., Adjunct Assistant Professor Leonard A. Mermel, D.O., Professor, Rhode Island (Research) Hospital, University Medicine Foundation Pamina Gorbach, M.H.S., Dr.P.H., Adjunct Assistant Maria D. Mileno, M.D., Associate Professor, Professor, Miriam Hospital Miriam Hospital, University Medicine Foundation Peter N. Herbert, M.D., Adjunct Professor, Jennifer A. Mitty, M.D., Assistant Professor, Miriam Hospital Miriam Hospital, University Medicine Foundation Alan S. Katz, M.D., Adjunct Associate Professor, Michael C. Newstein, M.D., Ph.D., Assistant Professor Rhode Island Hospital (Research), Miriam Hospital G. Richard Olds, M.D., Adjunct Professor, Marguerite A. Neill, M.D., Associate Professor, Miriam Hospital Memorial Hospital of Rhode Island Renee Ridzon, M.D., Adjunct Assistant Professor, Steven M. Opal, M.D., Professor, Rhode Island Hospital Memorial Hospital of Rhode Island Rodrigo Romulo, M.D., Adjunct Assistant Professor *David L. Pugatch, M.D., Assistant Professor, (Research), Miriam Hospital Rhode Island Hospital Harry Schrager, M.D., Adjunct Assistant Professor, Bharat Ramratnam, M.D., Assistant Professor, Rhode Veterans’ Administration Medical Center Island Hospital, University Medicine Foundation Gail Skowron, M.D., Adjunct Associate Professor, *Emma M. Simmons, M.D., Assistant Professor, Roger Williams Medical Center Memorial Hospital of Rhode Island Stephen Zinner, M.D., Adjunct Professor, Josiah D. Rich, M.D., M.P.H., Professor, Rhode Island Hospital Miriam Hospital, University Medicine Foundation *Faculty with secondary appointments in Medicine Karen T. Tashima, M.D., Associate Professor, Miriam Hospital, University Medicine Foundation Lynn E. Taylor, M.D., Assistant Professor (Research), Miriam Hospital, University Medicine Foundation Edward J. Wing, M.D., Chairman of Medicine and Joukowsky Family Professor of Medicine; Physician-in-Chief, Rhode Island Hospital, The Miriam Hospital, Miriam Hospital University Medicine Foundation

VOLUNTEER FACULTY Rinchen-Tzo Emgushov, M.D., Clinical Instructor, Rhode Island Hospital Glenn Fort, M.D., Clinical Associate Professor, Memorial Hospital of Rhode Island Dennis Mikolich, M.D., Clinical Associate Professor, Veterans’ Administration Medical Center N. Kumarasamy, Ph.D., Research Associate Suniti Solomon, M.D., Research Associate Kevin C. Vigilante, M.D., Clinical Associate Professor, The Miriam Hospital

96 brown medical school department of medicine

FACULTY TRANSITIONS

Departing Faculty

Name Prior Position Faculty Rank Daniel Boden, M.D. Post-doctoral fellow, Assistant Professor Aaron Diamond AIDS Research Center (Research) Wendy Clough, M.D. Clinical Associate Professor Oliver Pusch, Ph.D. Assistant Professor, University of Vienna Assistant Professor (Research) New Faculty

Name Prior Position Faculty Rank Jeffrey P. Bratberg, Clinical Assistant Professor of Pharmacy Clinical Assistant Pharm D. Practice, University of Rhode Islandr Professor John D. Cahill, M.D. Assistant Professor, Dept of Community Health Assistant Professor of Medicine Patricia A. Cristofaro, M.D. Infectious Diseases Fellow, Brown Medical School Assistant Professor (Research) Rami Kantor, M.D. Infectious Diseases Fellow, Assistant Professor Stanford University Medical Center (Research) Erna M. (Milu) Kojic, M.D. Research Fellow, Brown Medical School Assistant Professor Steven LaRosa, M.D. Assoc Staff Physician, Cleveland Clinic Assistant Professor Troy Martin, M.D. Infectious Disease Fellow, Brown Medical School Instructor of Medicine

NATIONAL AND INTERNATIONAL Southern New England, United Nurses and Allied HONORS AND RECOGNITION Professionals, and Tobey Hospital OF FACULTY I HIV and HVC: A Tale of Two Epidemics, to Positive Action Against Chemical Addiction Andrew W. Artenstein, M.D. I Schwartz Center Rounds: When an HIV Test Invited Presentations: Comes Back Positive to Memorial Hospital of I Biological Warfare, Bioterrorism and Defense to the Rhode Island Massachusetts Association of Hazardous Materials I Biodefense for Traditional First Responders” to the Technicians Rhode Island Fire Chiefs’ Association I Smallpox Preparedness – Preliminary Data from I Bioterrorism and Smallpox, to Infection Control New Smallpox Trials, to Northeast Regional Professionals of Southern New England Epidemiologists I A Brief History of U.S. Military Contributions to I Biodefense for Biodefenders” to the Rhode Island Vaccine Agents for Infectious Diseases to the Department of Health, Rhode Island Disaster Armed Forces Infectious Diseases Society Medical Assistance Team, Rhode Island Chapter of I Novel Inhibition of Anthrax toxin and Novel American College of Physicians, Walter Reed Army Smallpox Vaccines, to the Center for Infectious Institute of Research, South County Hospital, and Disease and Vaccine Research, UMass Worcester Gateway Healthcare; “Vaccines and Pharmaceuticals” Medical School to the Northeast Branch of the American Society for I Biodefense for Biodefenders to the Walter Reed Microbiology Army Institute of Research I Biodefense: SARS, Monkeypox and the Next Big I Biodefense for Biodefenders to Gateway Healthcare Thing, to Infection Control Professionals of

97 infectious disease

I Novel Approaches to the Inhibition of Anthrax Approve?,” Johns Hopkins Bayview Medical Center, Toxin, to Harvard Medical School 2004. I HIV Update 2004 to Southern New Hampshire I Participant in a program on roll-out of antiretroviral Medical Center medications in a Clinton Foundation HIV/AIDS I HIV and HCV: A Tale of Two Epidemics to Initiative sponsored program in New Delhi, India Southern New Hampshire Medical Center from November 16-23, 2004. I I Overview of the Center for Biodefense and Presented the Opening Address at the Ninth Emerging Pathogens at Brown Medical School to International Conference on Emerging and New England Regional Center of Excellence for Reemerging Infections in Asia and the Pacific Rim Biodefense and Emerging Infectious Diseases in Kyoto, Japan on December 10, 2004. (NERCE/BEID) I Invited Faculty member at the 1st National conference I Biodefense for Biodefenders to St. Luke’s Hospital of the AIDS Society of India in New Delhi, India on April 2-4, 2005 where he presented an update on I Biodefense for Biodefenders to Memorial Hospital antiretroviral therapy. of Rhode Island I Presented a summary of Brown University overseas I Security in an Insecure World to Memorial work at the University Consortium on Global Health, Hospital of Rhode Island sponsored by Boston University on April 26-27, 2005. I Smallpox in the 21st Century at URI Smallpox I Chaired a meeting of the Adolescent Trials Network Exercise, sponsored by the Rhode Island for HIV/AIDS Interventions (ATN) of the Data and Department of Health Safety Monitoring Board of the National Institute I Expecting the Unexpected: Is your Business of Child Health and Human Development Prepared? to Business Continuity and Safety (NICHD) in Washington, DC on May 9, 2005. Planning Conference I Moderator of a seminar on Sexually Transmitted I Biodefense for Physicians to St. Anne’s Hospital Diseases at the 25th Anniversary meeting of the I Biodefense for Biodefenders to Hope Valley American Society for Reproductive Immunology in Healthcare Providence on June 16, 2005. I Biodefense for Primary Care Physicians to Tobey E. Jane Carter, M.D. Hospital I Vice President and Program Chairman, North Charles C.J. Carpenter, M.D. American Region of the International Union I John E. Fogarty International Center Recognition Against TB and Lung Disease 2003- present Award for International Health, 2003 I President, Board, International Tuberculosis I John H. Chafee Leadership in Health Care Award, Foundation American Heart Association, 2004 I Reviewer: The International Journal of Tuberculosis I W.W. Keen Award, Brown Medical Alumni and Lung Disease Association, 2004 I Abstract Reviewer, International AIDS conference. I Reviewer, IOM report “Scaling up Treatment for Bangkok, Thailand. July 11-16, 2004 the Global AIDS Pandemic,” National Academies Invited Presentations: Press, 2004. I Participant, International TB Consultancy Training I Chair, Treatment Subcommittee and Member, Course, University of Alberta, Anne Fanning (Course Executive Committee Director), One year course distance based learning initiative funded through USAID, July 2002-2003. I IOM Committee, President’s Emergency Plan for AIDS Relief, (PEPFAR), 2004 I Participant, International TB Consultancy Course, Invited presentations: NAR IUATLD/ATS/Gorgas TB Initiative, Ed Nardell (Course Director), Cambridge, Massachusetts, June I George L. Ackerman Visiting Professor, The University of Arkansas For Medical Sciences 2003 College of Medicine, Little Rock, Arkansas, 2003. I Rheumatology Grand Rounds, Brown University, January 2003, TB Guidelines in Arthritis Patients: I Visiting Professor and Grand Rounds lecture titled “HIV Treatment Guidelines: Would Dr. Hippocrates Rheum for Improvement 98 brown medical school department of medicine

I Grand Rounds, Memorial Hospital of Rhode I HIV in Women. Annual Southeastern Massachusetts Island, Pawtucket, Rhode Island, December 2003, HIV Conference, September 26,2003, Fall River, MA Tuberculosis update: What’s new in 2003? I Gynecologic Issues in HIV-Infected Women. I Panel Participant-The Global Consequences of Women and HIV: Improving Reproductive Health AIDS: Reconnaissance on the Worldwide Impact- Care for HIV Infected Women. October 15, 2003, The Pandemic and Treatment. April (24) 2004. Springfield, MA. Pandemic/AIDS Symposium. Brown University, I Susan Cu-Uvin. M.D. and Joseph I. Harwell, M.D. Providence, Rhode Island. gave a lecture on Prevention and Management of STDs in Persons Living with HIV/AIDS. Sponsored Patricia Cristofaro, M.S. by the New England AIDS Training Center and the I Microbicidal potential of RNA interference in vivo Brown University AIDS Program at the Miriam Presented at CROI (Conference on Retrovirus amd Hospital, Brown University, February 19, 2004. Opportunistic Infections) Feb. 25, 2005. I Grand Rounds, Univ. of Colorado Health Sciences I Grand Rounds Roger Williams Hospital (BU affili- Center, Denver, CO, April 22, 2004, Gynecological ate) June 2004 Infectious Endocarditis - Diagnosis Care: Concerns of HIV-infected Women. I Lecturer Brown Geriatrics Fellows Program 7/03 I Clinical Care of HIV Infected Women Conference Infection and Fever in the Elderly sponsored by the Colorado Women’s HIV Susan Cu-Uvin, M.D. Consortium, Denver, CO, April 23, 2004: I Adult AIDS Clinical Trials Group (ACTG): Chair - Gynecological Care: Concerns of HIV-infected Women’s Health Committee, Scientific Advisory Women. Steering Committee. 2004-Present I Gender, Stigma, Power, and AIDS: Women, Families I HIV Prevention Trials Network: Perinatal Working and HIV/AIDS Research. University of North Group. 2000-Present Carolina at Chapel Hill, CFAR: May 14-15, 2004. Effect of Ovulatory Cycle on HIV Shedding in the I Pediatric AIDS Clinical Trials Group (PACTG) Perinatal Research Advisory Committee, Obstetrics Female Genital Tract. Subcommittee. 2001-Present. I ID Grand Rounds, University of Massachusetts, Worcester, MA. May 28, 2004. HIV in Women. I Member, Global Microbicide Project Scientific Advisory Group. 2001-Present. I Course Director: Women, HIV, and Pregnancy: Exploring Reproductive and Contraceptive I NIH Advisory Committee: HIV-Related Research in Women and Girls. 2002-Present. Options. June 2, 2004, Providence Marriott. I BRUNAP Update from the XV International AIDS I NIH Advisory Committee: HIV Related Research in Microbicides. 2002-Present. Conference. HIV in Women. Brown University, August 24, 2004. I Member, NIH AIDS Clinical Studies and I Epidemiology Study Section. 2004-2008. Problems of HIV-infected Women in Southern India. World AIDS Day Presentations, BRUNAP, I Board of Directors, HIV Medical Association. 2004- Dec. 1, 2004, Brown University. 2007. I Women and Children. World AIDS Day Invited Presentations: Celebration. AIDS Vaccine Development, GAIA I January 14, 2003. Fertility regulation and Systemic Foundation, Dec. 3, 2004. Hormones in HIV-infected and at Risk Women. I McLean, Virginia. Effect of Menstrual Cycle on Opportunities for Professional Writing. The Office Virologic Parameters (lecture). Course organizer. of Women in Medicine, Brown Medical School, Dec. 8, 2004. I Course Director and Lecturer: HIV Testing During Pregnancy, Marriott Hotel, Providence, RI, May 2003 Staci A. Fischer, M.D. I HIV Shedding in the Female Genital Tract: I Infectious Diseases Society of America Immunologic and Biologic Correlates. American Representative to the Centers for Disease Control Society of Reproductive Immunology, Yale and Prevention Organ Transplant Infection University, June 20, 2003. Prevention and Detection Program I HIV in Women. The Aultman Institute CME I Member, Education Committee, Rhode Island Activity, Canton, Ohio, September 17, 2003. Chapter, American College of Physicians. 99 infectious disease

I Reviewer, Transplantation I Lecture: Infections in Renal Transplantation. I Fellow, Society of Healthcare Epidemiology of Chicago Infectious Disease Board Review Course, America Chicago, Illinois, October 2004. Invited Presentations: I Lecture: Infections in the Transplant Patient. I Brown Medical School, Division of Trauma Surgery, Neighborcare RI Pharmacy, Providence, Rhode Providence, Rhode Island, September 19, 2003. Island, October 20, 2004. Lecture: MRSA in 2004: An Update. I Lecture: Infected Hardware and Traumatic Osteomyelitis. Brown Medical School, Division of I Evidence-Based Approach to the Practice of Nephrology, Providence, Rhode Island, October 2, Internal Medicine: 2004 Update, Rhode Island 2003. Chapter American College of Physicians, Newport, Rhode Island, October 27, 2004. I Lecture: Infections Complicating Hemodialysis and Peritoneal Dialysis. Chicago Infectious Disease Board I Lecture: Antimicrobial Treatment in the Outpatient Review Course, Chicago, Illinois, October 2003. Setting. Infection Control Professionals of Southern New England Seminar (ICPSNE), Providence, I Lecture: Infections in the Transplant Patient. Rhode Island, November 3, 2004. Cranston Senior Center, Cranston, Rhode Island, December 3, 2003. I Lecture: An Update on Respiratory and Gastrointestinal Diseases. Infectious Disease I Lecture: Infections Complicating Diabetes. Brown Fellowship Lecture Series, Rhode Island Hospital, Medical School, Providence, Rhode Island, January Lecture Topics: Osteomyelitis and Septic Arthritis, 27, 2004. HIPAA Training, Bone and Joint Infections, I Grand Rounds Presentation: M&M – A 83-year-old Peritonitis/Intra-abdominal Infections, Infections man with fever, headache and mental status in SOT, Infections in Acute Leukemia, BMT. changes. Brown Medical School, Division of I Noon Conference, Department of Medicine, Brown Infectious Diseases Providence, Rhode Island, Medical School, Providence, Rhode Island, Lectures: February 20, 2004. Fever of Unknown Origin, Meningitis/HSV I Grand Rounds Presentation: Transplanting the Encephalitis, Infections in the Immunocompromised HIV-Infected Patient. Brown Medical School, Host, Tick and Mosquito-borne Infections, Providence, Rhode Island, May 4, 2004. Endocarditis. I Grand Rounds Presentation: M&M – A 28-year-old I Pathophysiology Course, Brown Medical School, man with persistent fever and odynophagia. Providence, Rhode Island, Lecture: Central Nervous I Update in Internal Medicine, Brown Medical System Infections School, Providence, Rhode Island, May 7, 2004: Lecture: An Update on Meningitis and Encephalitis. Timothy P. Flanigan, M.D. I Clinical Research Review Committee, National I Introduction to Clinical Nephrology Board Review Center for Research Resources. NIH. Course, Rhode Island Hospital, Providence, Rhode Island, September 2, 2004. I Abstract Reviewer, International AIDS conference. Bangkok, Thailand. July 11-16, 2004. I Lecture: Urinary Tract and Dialysis Associated Infections. Brown Medical School, Providence, I Invited Graduation Speaker and recipient of Rhode Island, September 14, 2004. Honorary Degree, Doctor of Humane Letters, Salve Regina University, June 2004 I Grand Rounds Presentation: M&M – A 67-year-old asplenic female with fatigue and jaundice. Invited Presentations: I Antiviral Regimen Special Topics. Bristol Myers I United Network for Organ Sharing / The Organ Squibb Virology Phase IV Investigators Meeting, Procurement and Transplantation Network New York, NY, August 23, 2003. (UNOS/OPTN) Region Forum, Westborough, MA, September 28, 2004. Lecture: Emerging Pathogens I Incarcerated Women’s Health Meeting. DHHS. in Solid Organ Transplantation. “HIV Infection in Incarcerated Women”. Framingham, MA, September 30, 2003. I Introduction to Clinical Nephrology Board Review Course, Rhode Island Hospital, Providence, Rhode I Hepatitis C Infection and Substance Abuse. Island, September 30, 2004. NIDA/NIH. “DOT: Lessons Learned from HIV 100 Treatment,”Washington, DC, November 11-13, 2003. brown medical school department of medicine

I Invited Speaker at Symposium on Tropical Medicine I “Research Development”.Workshop on research and Infectious Diseases entitled, “ Looking Back, preparedness. Sihanouk Hospital Center of HOPE. Looking Forward”.A Tribute to Benjamin H. Kean, Phnom Penh, Cambodia November 12, 2004. MD. 1912-1993. New York, NY. October 20, 2003. I “How to write a research proposal”.Workshop on I Grand Rounds. Brown Medical School. “Influenza research preparedness. Sihanouk Hospital Center of in 2004!”,Providence, RI. January 6, 2004. HOPE. Phnom Penh, Cambodia November 16, 2004. I Grand Rounds. Brown Medical School. I A 36 Month Longitudinal Study of Cervicovaginal “Occupational Transmission of HIV, Hepatitis B & HIV-1 Shedding”.Women and Infants Hospital, C, and Prevention”.March 30, 2004. Providence, RI. Regional Meeting for BIRCWH I Panelist, “The Pandemic and Treatments”,and “The Scholars Program. May 31, 2005. Evolution of HIV Care”.Conference: Pandemic: Rami Kantor, M.D. Imaging AIDS. Watson Institute for International I Reviewer: Lancet, Journal of Infectious Diseases, Studies, Brown University, Providence, RI. April 24, Journal of AIDS, Antiviral Therapy, HIV Clinical 2004. Trials I Visiting Lecturer. Case Western Reserve University, I Member of and advisor to HIV ResNet, the World Cleveland, Ohio. May 7, 2004. Health Organization Gobal HIV Drug Resistance I “Antiviral Treatment for HIV”.Cancer Grand Rounds. Surveillance Network Rhode Island Hospital. Providence, RI. June 10, 2004. I International conference organizer: 9th I The IDSA affiliated Event: “Challenges In Addressing International Workshop on Virus Evolution and Infectious Diseases Among Substance Users” a Round Molecular Epidemiology. Stanford University, Table Discussion, IDSA, September 2004, Boston, MA, Stanford, California, USA. August 13-23, 2003. Timothy Flanigan, MD (Moderator) I International workshop organizer and Faculty: I Timothy P. Flanigan, M.D. “Toxicities of HAART TREAT Asia Workshop on HIV Drug Resistance. and Management”,and “Adherence to HIV in Prison Chulalongkorn University, Bangkok, Thailand. Populations”.1st National Conference of AIDS October 12-13, 2004. Society of India. New Delhi, India. April 2-4, 2005. I Member of an external peer review panel, The Melissa Gaitanis, M.D. National Center for HIV, STD, and TB Prevention I Member, Recombinant DNA Committee, Lifespan (NCHSTP), Centers for Disease Control and Hospitals. 2005 Prevention (CDC), Atlanta GA (8/2004). I Travel scholarship, 10th Conference on Retroviruses Joseph I. Harwell, M.D. and Opportunistic Infections, February 10-14, I Member, American Academy of Pediatrics (AAP), 2003; Boston, Massachusetts, USA. Section on Infectious Diseases I Invited speaker: “Drug Resistance Testing and I Member, American Academy of Pediatrics, Interpretation in HIV-1 Non-B Subtypes”.15th Med/Peds Section International AIDS Conference, July 12-16, 2004; I Pediatric Consultant- Clinton HIV/AIDS Initiative Bangkok, Thailand. China and Cambodia programs I Invited speaker: “WHO Global HIV Drug Invited Presentations: Resistance Database Model and Steps Towards I Biomed 282, Pathophysiology of Infectious Diseases, Development”.WHO HIV Drug Resistance “The Herpes viruses,” Brown Medical School, Methodology and Database Meeting, June 28-30, Providence, RI. February 5, 2003; January 21, 2004. 2005; Atlanta, Georgia, USA. I “Paired plasma and cervicovaginal HIV-1 RNA I Invited speaker: (1) “Molecular Basis of Drug expression over 36 months”.Center for Resistance”; (2) “Drug Resistance Databases and Interdisciplinary Research in Women’s Health 2004 Interpretation”.National Consultation on Drug Research Symposium, Farmington, CT. May 11, 2004. Resistance in Malaria, Tuberculosis and HIV/AIDS, I “Adherence”.Clinical care symposium on the man- September 19-21, 2005; Mumbai, India. agement of HIV infection in women. Phnom Penh, Michelle A. Lally, M.D., MSc Cambodia July 8-11, 2004. I Judge, Young Investigator Award Competition, Brown’s Annual Hospital Research Celebration, 2003 101 infectious disease

I Intern Faculty Advisor, Residency Programs in I A 48-year-old man with mental status changes, Medicine, Brown Medical School, 2004 hypothermia, and acute renal failure (Right-sided Invited Presentations: acute bacterial endocarditis due to Staphylococcus I Invited Panelist: “Preventing HIV and AIDS in the aureus with multiple septic emboli). Grand Future”,Brown University Pandemic AIDS Rounds, Rhode Island Hospital and Miriam Symposium, Brown University, Providence, RI, Hospital, Providence, RI. May 4, 2004. April 23-25, 2004 I Bioterrorism. Newport Hospital, Newport, Rhode I Invited Presenter: “AIDS Vaccine”,57th Clinical Island. October 12, 2004. Laboratory Science Society of Central New England I Biodefense for Biodefenders: Bioterrorism Training Annual Meeting, RI Convention Center, for Rhode Island Community Healthcare Centers. Providence, RI, May 11, 2005 Woonsocket, RI. April 29, 2005. I Invited Presenter: “HIV Vaccine Research Efforts”, I Emerging Infectious Diseases: Marburg, Avian GAIA Vaccine Foundation, GAIA World AIDS Influenza and Community-acquired MRSA. Butler Vaccine Symposium, Providence, RI, May 13, 2004. Hospital, Providence, RI. June 2, 2005. I Sticking to 23S. Infectious Diseases Grand Rounds. Steven P. LaRosa, M.D. Brown Medical School. June 8, 2005. I Director, Ocean State Clinical Coordinating Center I Staphylococcal Endocarditis. Medical Grand I Member, Clinical Evaluation Committee, BAR03 Rounds. Rhode Island Hospital and Miriam Phase III study of PAFase in Severe Sepsis Hospital, Providence, R.I., June 21, 2005. I Member, Clinical Evaluation Committee, TFP008 Study Kenneth H. Mayer, M.D. I Listed in: Best Doctors in America 2003-2004 John R. Lonks, M.D. Medical Achievement Award. AIDS Project Rhode I Director, Bio 351, Integrated Medical Sciences, Island Annual Meeting, Warwick, RI Pathophysiology of Infectious Diseases and Editorial Boards: Pharmacology of Anti-infective agents. Brown I Editorial Board, AIDS Alert Medical School. I Medical Editor, AIDS/HIV Treatment Directory I Hospital Epidemiologist and Chair, Infection (published by American Foundation for AIDS Control Committee, The Miriam Hospital Research) I “Top Doc” (Infectious Diseases) Rhode Island I Editorial Board, Opportunistic Infections in HIV Monthly, May 2004 Infected Patients Invited Presentations: I International Editorial Advisory Committee, I A 72-year-old male presenting with worsening SOB Actualizaciones en Sida (Spanish language AIDS (Empyema). Medical Grand Rounds, Rhode Island journal) Hospital and Miriam Hospital, Providence, R.I., October 7, 2003. I Editorial Advisory Board, Clinical Microbiology and Infection I A 63-year-old man presents with ascites and abdominal pain (Sub-acute bacterial peritonitis). I International Editorial Advisory Committee, Medical Grand Rounds, Rhode Island Hospital and Atualizacao em AIDS (Brazilian AIDS Journal) Miriam Hospital, Providence, R.I., October 7, 2003. I Editorial Board, AIDS Patient Care and STDs I Clinical Impact of Macrolide Resistance. Macrolide I Special Topics Editor HIV/AIDS, Clinical Infectious Failure Experts Summit. St. Pete Beach, Florida. Diseases March 21-22, 2004. Invited Presentations: I A 23-year old woman at 12 weeks gestation with I Kumarasamy N, Schaguturu K, Yepthomi T, Flanigan fever, abdominal pain, and hypotension (Typhoid TP, Balakrishnan P, Solomon, Mayer KH. Frequency of fever). Grand Rounds, Rhode Island Hospital and Immune Reconstitution Syndrome Among HIV-TB Miriam Hospital, Providence, R.I. April 6, 2004. I Coinfected Individuals After Initiation of Generic I Macrolide-resistant pneumococcus. Grand Rounds. Antiretroviral Therapy in India (poster presentation). Roger Williams Medical Center, Providence, RI. The 2nd IAS Conference on Pathogenes and 102 April 6, 2004. Treatment, Paris, France, July 12 - 16, 2003. brown medical school department of medicine

I Discussant, Panel: Providers and Trainers. Officers in collaboration with the Brown University Workshop: Prevention Interventions with Persons AIDS Program, Warwick, RI, December 11, 2003. Living and HIV/AIDS: NIH/CDC/HRSA Update, I Panel member, The Rhode Island Perspective, “The Atlanta, GA, July 26-27, 2003. Role of The Fogarty International Center in I Moderator: HIV Formative Research for New Globalization of Health Care,” Senator Jack Reed and Prevention Technologies. CDC 2003 National HIV Brown University, Providence, RI, December 18, 2003. Prevention Conference, Atlanta, GA, July 28, 2003. I Opening Remarks and Closing Remarks, Second I Moderator: The Use of Anti-retroviral to Prevent Annual Northeast Regional Advisory Meeting- HIV Transmission. CDC 2003 National HIV Optimizing Antiretroviral Therapy, Brown University Prevention Conference, Atlanta, GA, July 28, 2003. AIDS Program, Providence, RI, January 9-10, 2004. I “Sexually Transmitted Diseases in MSM in Boston,” I Clinical Implications for HIV Prevention, Second Monitoring Trends in Prevalence of STDs, Annual Northeast Regional Advisory Meeting- Tuberculosis and HIV Risk Behaviors among Men Optimizing Antiretroviral Therapy, Brown University Who Have Sex with Men Project (MSM Project). AIDS Program, Providence, RI, January 9-10, 2004. Centers for Prevention Control and Prevention, I Co-Chairperson, ART Where Are We? 20th Chicago, IL, September 17, 2003. National Conference on Management of HIV/AIDS I “HIV and STI Prevention: Adding Microbicides to in Resource Restricted Settings, Mumbai, India, the Mix, University of Massachusetts Medical Center February 21-22, 2004. I.D. Rounds, Worcester, MA, September 26, 2003. I The Biology of HIV Transmission and Prevention, I The Second Century of AIDS, AIDS Project 20th National Conference on Management of Worcester, Worcester, MA, September 26, 2003. HIV/AIDS in Resource Restricted Settings, I Presenter: “Management of HIV/AIDS in Resource Mumbai, India, February 21-22, 2004. Limited Settings,” Intensive Update Course in I Update on Microbicides to Prevent HIV Clinical Tropical Medicine and Traveler’s Health, Transmission, 20th National Conference on American Society of Tropical Medicine and Management of HIV/AIDS in Resource Restricted Hygiene, San Diego, CA, October 8, 2003. Settings, Mumbai, India, February 21-22, 2004. I Discussant, Panel: HIV/AIDS in 2003: An Update I Meet-the-Expert Presenter, Challenges in HIV on Epidemiology, Prevention, and Treatment, 21st Management, 11th International Congress on Annual Conference of the Gay and Lesbian Medical Infectious Diseases, Cancun, Mexico, March 4-7, 2004. Association, Miami, FL, October 30 - November 1, I Invited Speaker, Impact of HAART on Infectiousness, 2003. 11th International Congress on Infectious Diseases, I Co-Presenter, The Core Data Project at Fenway Cancun, Mexico, March 4-7, 2004. Community Health: Capturing Uniform ‘Data on I Chair, Novel Mechanisms and Formulations, Salient Characteristics of Sexual Minority Patients, Microbicides 2004, Imperial College, London, 21st Annual Conference of the Gay and Lesbian March 28-31, 2004. Medical Association, Miami, FL, October 30 - I Organizer and CME Course Director, PANDEMIC: November 1, 2003. Providing Hope, Pandemic/AIDS Symposium, I Workshop presenter, When to switch ART and what Brown University, Providence, RI, April 23-25, 2004. to switch to? Satellite Workshop: Antiretroviral I Microbicides and Post-exposure Prophylaxis— Therapy, 4th International Conference on AIDS Chemical Condoms, Pandemic/AIDS Symposium, India, Chennai, India, November 9-12, 2003. Brown University, Providence, RI, April 23-25, 2004. I Plenary Speaker, Can HAART prevent HIV? I Biology of HIV transmission: implications for pre- Plenary Session: Prevention package, 4th vention, prevention counseling in developing coun- International Conference on AIDS India, Chennai, tries and related issues eg STD control. Preparatory India, November 9-12, 2003. Course for HIV Healthcare Provider Volunteers, I Introductory Remarks. Prevention and Treatment of International Center for Equal Healthcare Access, Infectious Disease in Prison: What Corrections- Columbia University School of International and Based Staff Need to Know, RI Department Of Public Affairs, Princeton, NJ, May 1-2, 2004. Corrections and the RI Brotherhood of Correctional 103 infectious disease

I The Rising Rate of STIs: Challenges and Barriers in I Presenter, Rectal Microbicides: The Search for the Education and Transmission Prevention Barriers and Magic Lube, EXPLORE Research Forum, Boston, Bridges: Emerging Trends in HIV/AIDS, 8th Annual MA, September 13, 2004. Lemuel Shattuck Hospital HIV Conference, I Faculty, Prevention, Microbicides and the Science Massachusetts Department of Public Health/New of STDs, Update from the XV International AIDS England AIDS Education and Training Conference, New England AIDS Education and Center/University of Massachusetts Medical Training Center, Provincetown, MA, September 18- School/Blue Cross Blue Shield of Massachusetts/ 19, 2004. Massachusetts Medical Society/John F. Kennedy I Principal Speaker, Update from the XV International Library and Museum, Boston, MA, May 6, 2004. AIDS Conference, University of Massachusetts I CME Course Director and Speaker, HIV Transmission Medical School Office of Continuing Education and and Prevention, Primary Provider AIDS Education New England HIV Pharmaceutical Collaborative, Program, Brown University AIDS Program, Brown New Bedford, MA, September 23, 2004. University, Providence, RI, May 8, 2004. I Post Exposure Prophylaxis and Prevention in I “HIV Update,” Medical Grand Rounds, Landmark Treatment Settings. 42nd Annual Meeting of IDSA, Medical Center, Woonsocket, RI, May 18, 2004. Boston, MA, October 2, 2004. I “HIV Update,” Medical Grand Rounds, Our Lady I Biology of HIV Transmission: implication for pre- of Fatima Unit, St. Joseph’s Hospital, North vention, prevention counseling in developing coun- Providence, RI, May 27, 2004. tries and related issues eg STD control. Preparatory I HIV Update, Contemporary Issues in Management, Course for HIV Healthcare Provider Volunteers, Harvard Medical School/Beth Israel Deaconess ICEHA, American University, Washington, DC, Medical Center, Boston, MA, June 3-5, 2004. October 29-30, 2004. I HIV Transmission and Prevention, 1st Annual HIV I The Evolution of YRG CARE: A case study in the Care: Prevention to Treatment, Rhode Island integration of HIV prevention, care and research in Chapter of Association of Nurses in AIDS Care and Southern India, Eighth Annual National Brown University AIDS Program, Providence, RI, Symposium of the NIH Centers for AIDS Research, June 18, 2004. Harvard Medical School CFAR, Boston, MA, I Plenary Lecturer, The Biology of HIV Transmission November 11, 2004. and Prevention: What we know and what we need to I Sexual Risk and HIV Seroconversion in Chennai, know. AIDS in India, Regional Symposium-Workshop India, World AIDS Day 2004, Brown University on Research, Trials and Treatment, National Institute AIDS Program, Providence, RI, December 1, 2004. of Mental Health and Neurosciences (NIMHANS), I Engaging The Community in HIV Vaccine Research, Bangalore, India, July 31-August 6, 2004. World AIDS Day Program, Brown University, I Biology of HIV/AIDS Prevention, AIDS in India, Providence, RI, December 3, 2004. Regional Symposium-Workshop on Research, Trials I Ethical Issues Related to Developing Collaborations in and Treatment, National Institute of Mental Health India, It’s a Small World: An IRB Seminar on and Neurosciences (NIMHANS), Bangalore, India, Conducting International Research, Brown University July 31-August 6, 2004. and Lifespan, Seekonk, MA, December 6, 2004. I Seminar Presenter, Academic Session, Seminar on I Rapporteur, “Implications for Men Who Have Sex The Biology of HIV Transmission: Prospects for with Men,” Expert Consultation on The Implications Prevention, Department of Biotechnology, University of Tenofovir as HIV Chemoprophylaxis, CDC, of Madras, Chennai, India, August 9, 2004. Atlanta, GA, December 9, 2004. I Design issues for clinical studies, Safety of ARV- I Speaker, “HIV and HSV Interactions, “CME containing Microbicides, with Particular Reference Symposium, YRG CARE, Chennai, India, January to Resistance, WHO/RHR, International 25, 2005. Partnership for Microbicides and the Centers for Disease Control and Prevention, Geneva, Switzerland, September 7-8, 2004.

104 brown medical school department of medicine

I Speaker, “The Biology of HIV Transmission— I Speaker, “HIV Research & Treatment.” Frontiers of Implications for Prevention.” Continuing Education Health Science: AIDS Forum. Museum of Science, Program, HIV/AIDS Transmission & Prevention: Boston, MA May 20, 2005. Sri Ramachandra Deemed University, Harvard I Speaker, HIV Transmission and Prevention, Primary Medical International, and Y.R.G. CARE, Chennai, Provider AIDS Education, Brown University AIDS India, January 26, 2005. Program, Providence, RI, May 21, 2005. I Speaker, Microbicides: Promises and Challenges, I Speaker, “HIV Transmission and Prevention.” 9th AIDS Frontiers Seminar Series. Harvard Initiative Annual HIV Update, Harvard Medical School, for Global Health, Boston, MA. February 23, 2005. Boston, MA. June 2-4, 2005. I Speaker, Update from the 12th Conference on I Moderator, Antiretroviral Resistance Monitoring, Retroviruses & Opportunistic Infections, Brown 2005 National HIV Prevention Conference, Atlanta, University AIDS Program, Providence, RI, March 3, GA, June 13, 2005. 2005. I Speaker, Current Research and Trends in STDs and I Panelist, HIV/AIDS in India: A Discussion Among HIV: Status of HIV Vaccine and Development of Experts, Brown University, Providence, RI, March 3, Microbicides, Massachusetts Department of Public 2005. Health, Boston, MA, June 16, 2005. I Moderator, Opportunistic Infectious. 1st National Conference of AIDS Society of India, New Delhi, Leonard A. Mermel, D.O. I India, April 2, 2005. Invited Moderator, Intravascular Catheter Associated Infection Session, 41st Interscience I Speaker, “ARVs in Prevention of HIV Infection,” Linking Prevention and Care, 1st National Conference on Antimicrobial Agents and Conference of AIDS Society of India, New Delhi, Chemotherapy, Chicago, Illinois India, April 3, 2005. I Invited Moderator, Preventing Infections in the ICU I Plenary Session Speaker, “Biomedical Prevention Session, Society for Critical Care Medicine 31st Interventions,” Prevention and Harm Reduction Annual Critical Care Congress, San Diego, California Plenary Session, 2005. National HIV/AIDS Update I Invited Moderator, Device-Associated Infections Conference, American Foundation for AIDS Research Session, 12th Annual Scientific Meeting of the and PAETC, Oakland, CA, April 10-13, 2005. Society for Healthcare Epidemiology of America, I Moderator, Vaccines and Vaccine Development, Salt Lake City, Utah 2005 National HIV/AIDS Update Conference, I Invited Member, Technical Expert Panel, Medicare American Foundation for AIDS Research and Patient Safety Monitoring System, United States PAETC, Oakland, CA, April 10-13, 2005. Department of Health and Human Services I Guest Speaker, HIV Treatment Update: 2005 I Invited Member, Guideline Committee on Retrovirus Conference, AIDS Care Ocean State and Prevention of Intravascular Catheter-Related AIDS Project RI. Providence, RI, April 14, 2005. Infections, Society for Critical Care Medicine, the I Plenary Session Speaker, “HIV Prevention Research Infectious Disease Society of America, and the – Where are We and Where are We Going?” 2005 Hospital Infection Control Advisory Committee to Group Meeting, Community Programs for Clinical the Centers for Disease Control & Prevention Research, Denver, CO, May 2, 2005. I Invited Advisor, Infectious Disease Society of I Speaker, “Manifestations of Shiva: Evolution of America Council Collaborations to Address HIV/AIDS in India.”Yale I Journal Advisory Board, Clinical Microbiology & International Research Seminar Series, Center for Infection Interdisciplinary Research on AIDS, Yale University Invited Oral presentations: School of Medicine, New Haven, CT, May 5, 2005. I International Conference-IV Therapy Home and I Speaker, Antiretrovirals and HIV Prevention: Hospital, Oxford Radcliffe Hospital Trust, Oxford, Promise or Peril? HIV Center for Clinical and England. Lecture: Prevention of Intravascular Behavioral Studies, NY State Psychiatric Institute, Catheter-Related Infections New York, NY, May 12, 2005. I Johns Hopkins University and University of Maryland Fellowship Training Course, Baltimore, 105 Maryland. infectious disease

I Lecture: Epidemiology and Prevention Bloodstream I Honorary Chairman, Physicians Advisory Board, Infection The National Republican Congressional I Interscience Conference on Antimicrobial Agents and Committee, 2003-present. Chemotherapy. Chicago, Illinois. Lecture: Treatment I Member, Clinical Research Review Board, The of Intravascular Catheter-Related Infections - Miriam Hospital (IRB) and appointed Associate Guidelines Based on Anecdotes, Wisdom or Facts Chair 2004. I Society of Critical Care Medicine Annual Meeting. I Member, Organizing Committee, 7th Meeting San Diego, California. Lecture: Novel Devices to International Society of Travel Medicine (ISTM), Prevent Catheter-Related Bloodstream Infections 2003. I CDC, Council of State & Territorial I Course Leader with Dr. Timothy Flanigan: Tropical Epidemiologists, Association of Public Health Topics Elective: Introduction to Tropical Medicine, Laboratories, WHO and American Society for Brown Medical School, February 2005. Microbiology International Conference on Emerging Infectious Diseases. Atlanta, Georgia. Jennifer A. Mitty, M.D. I Interdisciplinary Theoretical Perspectives on HIV I Lecture: Prevention of Intravascular Catheter- Adherence: Translating Knowledge into Practice 2003; Related Infections Mount Sinai Medical Center: New York, New York. I Washington University School of Medicine, I Mitty JA. Directly observed therapy (DOT) for Epidemiology 2002: An Update on Hospital individuals with HIV: successes and challenges. Epidemiology. St. Louis, Missouri. Lecture: Presented at Brown/Tufts/Lifespan Center for AIDS Epidemiology, Management and Prevention of Research Forum Presentation 2003; The Miriam Intravascular Catheter-Related Infections: Fables, Hospital: Providence, Rhode Island. Foibles and National Guidelines I Observed Therapy for HIV: A Community-Based I National Institutes of Health (NIAID), Infectious Intensive Adherence Intervention at Mt. Sinai March, Diseases Grand Rounds, Bethesda, Maryland. 2005 Lecture: Pathogenesis and Prevention of I Intravascular Catheter-Related Infections. NIAID An Update On Lyme Disease, Rhode Island Noon Conference Lecture: Management of Hospital Grand Rounds, April, 2005 Intravascular Catheter-Related Infections, A Review I Observed Therapy for HIV: A Community-Based of National Guidelines Intensive Adherence Intervention at BRUNAP, May, 2005 I National Foundation of Infectious Diseases, Centers for Disease Control & Prevention, US FDA, I An Update On Lyme Disease at Newport Hospital, US Department of Agriculture Conference on May 2005 Antimicrobial Resistance. Bethesda, Maryland. I Observed Therapy for HIV: A Community-Based Lecture: Antimicrobial Impregnated Catheters: Intensive Adherence Intervention at St. Elizabeth’s Clinical Impact and Theoretical Concerns? Hospital, MA, May 2005 I Rhode Island Hospital, Providence, Rhode Island. Marguerite A. Neill, M.D. Surgical Grand Rounds: Treatment of Intravascular I Chair, Bioterrorism Work Group, Infectious Catheter-Related Infections - Guidelines Based on Diseases Society of America Anecdotes, Wisdom or Facts I Board Member, Board of Scientific Counselors, I Rhode Island Healthcare Engineers Society, Rhode National Center for Infectious Diseases, Centers for Island. Regulations for Infection Control Relating Disease Control to Construction. American College of Physicians Annual Meeting of the Rhode Island Chapter, I Associate Director, Center for Biodefense and Warwick, Rhode Island. Panel Discussion: Emerging Pathogens, Memorial Hospital Bioterrorism & Chemical Warfare. I Steering Committee, Sixth International Symposium on Shiga-toxin producing Escherichia coli Maria Mileno, M.D. I National and Global Public Health Committee, I Quality Management Coordinator, Department of Infectious Diseases Society of America Medicine, The Miriam Hospital 2002-present. I Corresponding Editor, International Journal of 106 Infectious Diseases brown medical school department of medicine

I Editorial Board, Medicine and Health Rhode Island I “Influenza, Risk Reduction and Vaccine Shortage” I Invited Member, FDA Review Panel on Enterobacter Ocean State Ethics Network, Brown University, sakazakii and infant formula Providence, RI December 2, 2004“Biodefense: An Update on the State of Preparedness”,Providence Invited Presentations: District Dental Society, Providence, RI April 27, I Briefing for the U.S. Senate: “The Problem of 2005 “What’s New in Infectious Diseases”,Orear Declining Anti-infective Drug Development: Institute, Kansas City, MO June 23, 2005 Impact on Clinical Medicine and Bioterrorism “Bioterrorism and Emerging Pathogens – 2005” Preparedness”.March 12, 2003 Orear Institute, Kansas City, MO June 24, 2005 I “Immunocompromised Populations: Definitions, “Outpatient Infections – a Case Based Approach”, Demographics and Trends”.Symposium on Food Orear Institute, Kansas City, MO June 24, 2005 Safety for Immunocompromised Populations, Invited Presentations: International Association of Food Protection I Briefing for the U.S. Senate: “The Problem of Annual Meeting, Phoenix, AZ August 10, 2004 Declining Anti-infective Drug Development: Impact I “Hard Lessons: What Experience Has Taught Us on Clinical Medicine and Bioterrorism Preparedness”. about Operational Planning in Disasters and Bio- I “Immunocompromised Populations: Definitions, emergencies”.Symposium on Bioterrorism, Clinical Demographics and Trends”.Symposium on Food Medicine and Public Health: Consequence Safety for Immunocompromised Populations, Management at the Operational Planning Interface International Association of Food Protection - 42nd Annual Meeting, Infectious Disease Society Annual Meeting of America. Boston. September 30, 2004 I “Hard Lessons: What Experience Has Taught Us I “Recognizing Disease, Responding to Fear - Natural about Operational Planning in Disasters and Bio- Disease vs. Bioterrorism Event: a Case-Based emergencies”.Symposium on Bioterrorism, Clinical Approach”.Fellows’ Day Program, 42nd Annual Medicine and Public Health: Consequence Meeting Infectious Diseases Society, Boston, MA Management at the Operational Planning Interface September 30, 2004 - 42nd Annual Meeting, Infectious Disease Society I “An Introduction to Epidemiology”,and of America “Epidemiology Applied to Foodborne Disease”,lec- I “Recognizing Disease, Responding to Fear - Natural tures in •“Epidemiology and Foodborne Illness: Disease vs. Bioterrorism Event: a Case-Based How Disease is Detected and How Investigations Approach”.Fellows’ Day Program, 42nd Annual Proceed”.International Life Sciences Institute Meeting Infectious Diseases Society Course, February 1-2, 2005 I “An Introduction to Epidemiology”,and I “Bioterrorism”,The Netopian Club, Providence, “Epidemiology Applied to Foodborne Disease”,lec- February 26, 2003 tures in “Epidemiology and Foodborne Illness: How I “SARS: a status report”,Internal Medicine Grand Disease is Detected and How Investigations Rounds, Memorial Hospital. April 30, 2003 Proceed”.International Life Sciences Institute Course I “From SARS to Monkeypox:Lessons learned.” 1st I “Bioterrorism”,The Netopian Club Annual Medicine in the Time of Bioterrorism I “SARS: a status report”,Internal Medicine Grand Conference, Providence, RI November 11, 2003 Rounds, Memorial Hospital I “Antibiotics, Costs and Resistance: Squeezing the I “From SARS to Monkeypox:Lessons learned.” 1st balloon vs. Untying the Gordian Knot.” Medical Annual Medicine in the Time of Bioterrorism Grand Rounds, Memorial Hospital. June 16, 2004 Conference “Biodefense for Biodefenders”,Kent County Dental Society, East Greenwich, RI October 19, 2004 I “Antibiotics, Costs and Resistance: Squeezing the balloon vs. Untying the Gordian Knot.” Medical I “Biodefense and Bio-emergencies: The New Grand Rounds, Memorial Hospital Normal” 47th Annual Heber W. Youngken, Jr. Pharmacy Clinic, URI College of Pharmacy. I “Biodefense and Bio-emergencies: The New Kingston, RI November 11, 2004 Normal” 47th Annual Heber W. Youngken, Jr. Pharmacy Clinic, URI College of Pharmacy

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I “Influenza, Risk Reduction and Vaccine Shortage” I The 11th Annual meeting of the International Ocean State Ethics Network, Brown University Congress of Infectious Diseases. Cancun, Mexico. “Biodefense: An Update on the State of “The pathophysiology of septic shock.” March 7, Preparedness”,Providence District Dental Society 2004. I The first annual NIH biodefense research work- Steven M. Opal, M.D. shop. Translation of basic research findings in the Editor: bio -containment laboratory to the bedside. I 2003-Infectious Diseases (second edition): (Cohen Bethesda MD, June 14-15, 2004 and Powderly-senior editors), (S. Opal-Associate editor-Web site manager) Section Editor: Special I The Center for Bio-security University of Pittsburg problems in Infectious Disease practice (S. Opal & Medical Center-Baltimore MD. Lost in translation- J. Cohen) Mosby Harcourt Publishers LTD, the challenge of translational research in biode- London, U.K. (Publication date – 2003) fense. November 9th, 2004. I I 2003-The Sepsis Text; Editors: (J-L Vincent, J The 2nd Annual Symposium on Medicine in a time Carlet, SM Opal) Kluwer Academic Publishers, of bioterorism-Brown University School of Medicine. Boston MA (848 pages) (publication date – 2003) Biodefense research and the problems of translating bench research to the bedside. November 17th 2004. I 2007-Infectious Diseases (third edition): (Cohen and Powderly-senior editors), (S. Opal-Associate I The British Society for Immunology Annual editor-Web site manager) Section Editor: Special Congress. Cytokines as Mediators of Sepsis: A reap- problems in Infectious Disease practice (S. Opal & praisal. Harrogate, United Kingdom, December 7- J. Cohen) Saunders Publishers NY, NY. (Publication 10, 2004 date – 2007) I The 25th International Congress of Emergency I 2007-Clinical Advisor (F. Ferri senior editor), Medicine and intensive Care. “The threat of multi- Specialty editor- Infectious Diseases, Elsevier ple antibiotic-resistant nosocomial pathogens.” Publishers, London, UK Brussels Belgium, March 19, 2005. I I First Consult Editor in Chief – Specialty editors The 50th International Thoracic Society meeting. and editor of Infectious Diseases sections, Elsevier “The pathophysiology of septic shock.” San Diego, Publishers, London, UK (2005-) CA, May 22, 2005 I I Shock - Biomedical Press, Senior Editor: I. Chaudry The 24th International Congress of Chemotherapy. “Aging, infection and Cancer’ Manila, Philippines, I Critical Care Medicine - Lippincott, Williams and June 5, 2005 Wilkins: Senior Editor: J. Parrillo I Critical Care Forum - Current Science LTD, Senior Bharat Ramratnam, M.D. Editor: J-L Vincent I Reviewer, WHO guidelines for HIV diagnosis and I Advances in Sepsis - ReMedica Publishers E. monitoring of antiretroviral therapy. Abraham, Senior Editor Invited Presentations: Invited Presentations: I Engineering mucosal RNA interference, Rockefeller I Columbia University College of Physicians and University, NY, NY, September 2004 Surgeons Grand Rounds. The Role of Activated I Microbicidal potential of RNA interference, Protein C and Other Endogenous Anticoagulants in Controlled Release Society, Miami, FL, June 2005. the Treatment of Sepsis-2003 Josiah D. Rich, M.D., M.P.H. I 7th International Congress on PAF and Lipid I The AIDS Leadership Award from the Rhode Island Mediators. The potential role of PAFacetylhydrolase Community Planning Group for HIV Prevention in the prevention of ARDS, Tokyo, Japan-2003 I Medical Service Award from AIDS Project Rhode I Keio University Medical Grand Rounds. “New ther- Island, World AIDS Day apeutic Agents in the management of Sepsis”-2003 I Loan Repayment Reviewer: NIH/NIDA Special I The Nobel Symposium on septicemia. The link Emphasis Panel, Extramural Loan Repayment between coagulation and innate immunity-Karolinska Program, April, 2005. University. Stockholm, Sweden, May 18, 2003. I Planning Committee: 2005 National HIV Prevention 108 Conference, Atlanta, GA, June 12-15, 2005. brown medical school department of medicine

I Scholarship Reviewer: 2005 National HIV Prevention I Invited Speaker: “Defining HCV Care and Accessing Conference, Atlanta,GA, June 12-15, 2005. Health Care for the Drug Abuser in the Incarcerated I The AIDS Leadership Award from the Rhode Island Setting”.NIH Conference, Washington, DC. Community Planning Group for HIV Prevention I Invited Speaker: “World AIDS Day: Prevention and I Medical Service Award from AIDS Project Rhode Policy”.Council on Foreign Relations, Physicians Island, World AIDS Day for Human Rights (PHR) and CFR Africa Policy Studies Program (How the Bush Administration Invited Presentations: Can Prevent HIV Infections), Washington, DC. I Invited Speaker: “Patients Who Are Co-Infected with HIV and Hepatitis C.” Presidential Advisory I Invited Speaker: “Overview of HIV Infection”. Council in HIV/AIDS Prevention and Treatment of Infectious Disease in Prison, What Corrections-Based Staff Need to Know. I Invited Speaker: “Responding to Co-Occurring Rhode Island Dept. of Corrections in collaboration Disorders.” 3rd Annual New England •Association with Brown University AIDS Program, Warwick, RI. of Drug Court Professionals Conference, Roger Williams University, Bristol, RI I Invited Speaker: “Patients Who Are Co-Infected with HIV and Hepatitis C.” Presidential Advisory I Invited Speaker: “Discharge Planning: Project Council in HIV/AIDS (PACHA), Washington, DC. Bridge”.The University of Texas Medical Branch, School of Medicine, HIV Mini-Fellowship for I Invited Speaker: “Responding to Co-Occurring Correctional Health Care Providers, Providence, RI Disorders.” 3rd Annual New England Association of Drug Court Professionals Conference, Roger I Invited Speaker: “Failing Therapy - Adherence or Williams University, Bristol, RI. Resistance?”.HIV Management and Treatment Update, The Rhode Island Department of I Invited Speaker: “Discharge Planning: Project Corrections, Cranston, RI. Bridge”.The University of Texas Medical Branch, School of Medicine, HIV Mini-Fellowship for I Invited Speaker: “Defining HCV Care and Accessing Correctional Health Care Providers, Providence, RI Health Care for the Drug Abuser in the Incarcerated Setting”.NIH Conference, Washington, DC I Invited Speaker: “Failing Therapy - Adherence or Resistance?”.HIV Management and Treatment I Invited Speaker: “World AIDS Day: Prevention and Update, The Rhode Island Department of Policy”.Council on Foreign Relations, Physicians Corrections, Cranston, RI for Human Rights (PHR) and CFR Africa Policy Studies Program (How the Bush Administration I Invited Speaker: “Defining HCV Care and Accessing Can Prevent HIV Infections), Washington, DC Health Care for the Drug Abuser in the Incarcerated Setting”.NIH Conference, Washington, DC I Invited Speaker: “Overview of HIV Infection”. Prevention and Treatment of Infectious Disease in I Invited Speaker: “World AIDS Day: Prevention and Prison, What Corrections-Based Staff Need to Know. Policy”.Council on Foreign Relations, Physicians Rhode Island Dept. of Corrections in collaboration for Human Rights (PHR) and CFR Africa Policy with Brown University AIDS Program, Warwick, RI Studies Program (How the Bush Administration Can Prevent HIV Infections), Washington, DC I Invited Speaker: “Patients Who Are Co-Infected with HIV and Hepatitis C.” Presidential Advisory I Invited Speaker: “Overview of HIV Infection”. Council in HIV/AIDS (PACHA), Washington, D Prevention and Treatment of Infectious Disease in Prison, What Corrections-Based Staff Need to Know. I Invited Speaker: “Responding to Co-Occurring Rhode Island Dept. of Corrections in collaboration Disorders.” 3rd Annual New England Association of with Brown University AIDS Program, Warwick, RI Drug Court Professionals Conference, Roger Williams University, Bristol, RI I Invited Discussant: “An Epidemic by the Numbers: Categorizing, Counting and Constructing AIDS”.The I Invited Speaker: “Discharge Planning: Project Political and Symbolic Implications of Quantification Bridge”.The University of Texas Medical Branch, Conference, Brown University, Providence, RI. School of Medicine, HIV Mini-Fellowship for Correctional Health Care Providers, Providence, RI. I Invited Attendee: “A Multicultural Caribbean Against HIV/AIDS Conference.” Social and Scientific I Invited Speaker: “Failing Therapy - Adherence or Systems, Inc., Santo Domingo, Dominican Republic. Resistance?”.HIV Management and Treatment Update, The Rhode Island Department of 109 Corrections, Cranston, RI. infectious disease

I Invited Panelist: “Brown University Pandemic AIDS I Panelist. AIDS/HIV in the Black Community. Symposium.” Brown University, Providence, RI. Presented at Brown University. February 2005 I Invited Attendee: “Memo of Understanding Signing I Semi-Finalist Robert Wood Johnson Harold Amos (MOU), Providence/Samara (Russia) Partnership”. Minority Medical Faculty Development Program. Rhode Island State House, Governor’s Office, July 2005 Providence, RI, November 4, 2004. Karen T. Tashima, M.D. I Invited Participant: “Re-Accreditation by LCME”. I New England Chapter, Board of the American American Association of Medical Colleges and the Academy of HIV Medicine American Medical Association, Site Visitors I Meeting - Institutional Faculty Issues (Representing Member, Complications of HIV Disease Research Chair of MFEC), Arnold Labs, Providence, RI, Agenda Committee of the ACTG (AIDS Clinical October 26, 2004. Trials Group) I Member, Renal, Cardiovascular & Neurology I Invited Participant: “Challenges in Addressing Infectious Diseases Among Substance Users”, Subcommittees of the ACTG Investigator At-Large, Infectious Diseases Society of America (IDSA), Site Evaluation Subcommittee of the ACTG Round Table Discussion, Boston Marriott Copley I HIV Leadership Award as Outstanding HIV/AIDS Place, Boston, MA, September 29, 2004. Clinician from TheBody.com and TheBodyPRO.com I Invited Participant: “Prescribing Syringes to Invited Presentations: Injection Drug Users”,5th Annual Harm Reduction I “Update From the International AIDS Society (IAS) Conference, Working Under Fire: Drug Users Conference on HIV Pathogenesis and Treatment” Health and Justice, 2004, New Orleans, LA, Clinical AIDS Task Force series, Brown University November 11-14, 2004. AIDS Program I Invited Lecturer: “Advanced Infectious and I “Antiretroviral Resistance” Update on HIV Care Pulmonary Diseases”,Management of Infections in and Treatment for NPs & PAs, Braintree, MA, New Injection Drug Users, URI College of Pharmacy, England AIDS Education and Training Center URI PHP 430, April 5, 2005. I “Antiretroviral II” ID Fellow Lecture, Rhode Island I Invited Presenter: “Needle Exchange Program”,57th Hospital Clinical Laboratory Science Society of Central New I “Update on HIV Medications” Worcester Medical England Annual Meeting, RI Convention Center, Center, Worcester, MA Providence, RI, May 11, 2005 I “HIV Infection and Women” St. Raphael’s Hospital, I Invited Speaker: “Implementation of Hepatitis B New Haven, CT Vaccination in Correctional Facilities”,Centers for I “IAS Update and New HIV Treatment Options” Disease Control and Prevention, Division of Viral Providence, RI Hepatitis Consultation, Implementing Adult Hepatitis I “Biomed 282 Infectious Diseases Pathophysiology” B Vaccination Meeting, Atlanta , GA, May 18, 2005. Instructor for Group Sessions I Invited Speaker: “Barriers to Adult Vaccination”, I “HIV Update 2004” Charlton Memorial Hospital Centers for Disease Control and Prevention, Lecture, Fall River, Massachusetts Division of Viral Hepatitis Consultation, Implementing Adult Hepatitis B Vaccination I “HIV Didactic” Medical Residents, Nursing Arts Meeting, Atlanta, GA, May 18, 2005. Lecture Hall, Rhode Island Hospital, Providence, RI I “HIV Update” Brown University Infectious Disease Emma Simmons, M.D. Conference I Fleet’s Community Fellow Award, 2003 I “HIV Resistance Testing” 1st Annual RI Chapter I Routine Testing in the Primary Care Setting. ANAC Conference, Providence, RI Presented at CFAR lecture series. November 2003. I “Clinical Trial Presentation APRI Staff” AIDS I Panelist. The Pandemic: Facing AIDS. Presented at Project RI, Providence, RI Brown University. April 2004. I “Initial Evaluation of a Woman with HIV Infection” I Routine HIV Testing in the Primary Care Setting. Clinical Care Symposium on the Management of CPCP Translational Research Seminars. Memorial HIV Infection in Women, Phnom Penh, Cambodia 110 Hospital of RI. November 2004. brown medical school department of medicine

I “HIV/AIDS Clinical Research: What You Should Medical School, granted by the National Institute of Know!” Clinical Care Symposium on the Health, Boston, MA, 2003 – Management of HIV Infection in Women, Phnom I Scientific Review Study Section, National Institute Penh, Cambodia on Drug Abuse, National Institute of Health, RFA I “Atazanavir” Family Healthcare Center at SSTAR, 03-002 – “Enhancing HIV Vaccine Efficacy in High- Fall River, MA Risk Drug Users, “ Bethesda, MD, 2003 I “Increasing Women’s Participation in studies I Special Emphasis Panel, National Institute of Through a One-On-One Intervention” Allergy & Infectious Diseases, National Institutes of I “Recruitment and Retention of Women and Health, NOT-AI-04-044 – “Biodefense Minorities, Arlington, Virginia Countermeasures Development: Project Bioshield”, Bethesda, MD, 2004 I “HIV in Women Update” Buffalo Association of Nurses in AIDS Care, Buffalo, NY I Special Emphasis Panel, National Institute of Allergy & Infectious Diseases, National Institutes of Health, I “New Antiretroviral Therapies” CFAR Research-In- RFA-04-029 – “Challenge Grants: Biodefense Project Progress Seminar Series, The Miriam Hospital Development”,Bethesda, MD, 2005 I “Atazanavir Clinical Trials Results” Baystate Medical Center, Department of ID, Springfield, MA Charles C.J. Carpenter, M.D. I I “Rhode Island-based Clinical Drug Trials” World Board of Directors: HIV Medical AssociationPanel AIDS Day 2003, Brown University member: Guidelines for the Use of •Antiretroviral Agents in HIV-Infected Adults and Adolescents. I “HIV Treatment” Noon Conference Lecture Series, Developed by the panel on Clinical Practices for Rhode Island and The Miriam Hospital Treatment of HIV Infection convened by the Edward J. Wing, M.D. Department of Health and Human Services (DHHS) I Joukowsky Family Professor and Chairman, and the Henry J. Kaiser Foundation, July 14, 2003. Department of Medicine, Brown Medical School Susan Cu-Uvin, M.D. I Executive Physician-in-Chief, Memorial Hospital of I Chair: Women’s Health Committee, ACTG Rhode Island, Veterans’ Administration Medical I NIH advisory Committee: HIV related research in Center, Women & Infants Hospital Women and Girls I NIH Advisory Committee: HIV related research in RESEARCH AND OTHER Microbicides SCHOLARLY ACTIVITIES I NIH AIDS Clinical Studies and Epidemiology Study Section FACULTY MEMBERS OF STUDY SECTIONS AND I Board of Directors: HIV Medical Association ADVISORY COMMITTEES Timothy P. Flanigan, M.D. Andrew W. Artenstein, M.D. I Data Safety Management Board (DSMB) for I Hospital Emergency Preparedness Committee, NIH/NIMH. 2002-present Memorial Hospital of RI I Clinical Research Review Committee, National I Graduate Medical Education Committee, Memorial Center for Research Resources. NIH. 2004-08 Hospital of RI I Abstract Reviewer, International AIDS conference. I Co-Chair, Performance Improvement Committee, Bangkok, Thailand. July 11-16, 2004 Memorial Hospital of RI I Member, Board of Directors, Doctors of the World. I Infectious Diseases Fellowship Education 2004-present Committee, Brown Medical School I Executive Committee, Brown University Fogarty I Biosafety Lab 3 (BSL3) Facility Committee, Brown AIDS International Training and Research Program Medical School I Advisory Committee on Voluntary Foreign Aid I Scientific Steering Committee, New England (ACVFA), US Agency for International Regional Center of Excellence in Biodefense and Development (USAID), 2005-2007 Emerging Infectious Diseases (NERCE), Harvard 111 infectious disease

Joseph I. Harwell, M.D. I HIV Prevention in Clinical Care Working Group, I Member, AIDS Care Ocean State Board of Directors Centers for Disease Control and Prevention. I Planning committee, “HIV and Menopause”,Annual I Program Planning Committee for 16th National workshop on HIV in women, Providence RI HIV/AIDS Update Conference, American I Abstract Reviewer – 2005 National HIV Prevention Foundation for AIDS Research, March, 2004 Conference I Expert Panel member, “Evaluation of Adherence to I Site representative, HIV Prevention Trials Network, National STD Guidelines to Provide STD and STD Working Group Hepatitis Services in the Public and Provate Sectors to HIV-Infected Men who Have Sex with Men I Executive Committee, Brown University Fogarty (MSM),” National Center for HIV, STD, and TB AIDS International Training and Research Program Prevention, Centers for Disease Control and Kenneth H. Mayer, M.D. Prevention, Washington DC, January 13, 2004 I Consultant to the Massachusetts Department of I Board of Directors, LaJolla Foundation for Health, Division of Communicable and Venereal Microbicide Research Diseases I Promotions Committee, Brown Medical School I Medical Advisory Committee, Rhode Island Project Department of Medicine AIDS I Planning Committee for the 16th National I American Foundation for AIDS Research, Scientific HIV/AIDS Update Conference, amfAR. Advisory Committee I Search Committee, Professor (Epidemiologist), I Visiting Scientist, Massachusetts Institute of Department of Community Health, Brown University Technology Clinical Research Center I Planning Committee, 17th National HIV/AIDS I Member, Epidemiology and Technology Transfer Update Conference, American Federation for AIDS Subcommittee of the AIDS Research Review Research (amfAR). Committee (Study Section), NIAID I Program Committee, Treatment and Management of I International Scientific Committee, 2nd, 3rd, 4th, HIV Infection in the United States, US Department and 5th International Conferences on the Prevention of Veterans Affairs; Session Chair, Prevention Track. of Infection; (Nice, France 1992, 1994, 1996, 1998) Leonard Mermel, D.O. I National Board, American Foundation for AIDS I Special Government Employee, Anti-Infective Drug Research Chair, Treatment Information Services Products Advisory Committee, Center for Drug Subcommittee; Co-Chair: Clinical Research Committee. Evaluation & Research, US Food & Drug I Fellow, Wayland Collegium, Brown University Administration, 9/99-6/04 I Center for Alcohol and Addiction Studies, Brown I Invited Member, Technical Expert Panel, Medicare University Post-doctoral Training Program Faculty Patient Safety Monitoring System, US Department I Clinical Advisory Panel, Cost-Effectiveness of of Health and Human Services, 2003-2004 Preventing AIDS Complications (CEPAC), (NIH I Invited Peer Referee, Cochrane Anaesthesia Review RO1:K.Freedberg, PI), Boston University School of Group, 2003 Medicine/Harvard Medical School. I Oversight Committee Member, Society for Healthcare I Board of Directors, New England Chapter, Epidemiology of America /Infectious Diseases Society American Academy of HIV Medicine. of America Fellow’s Course on Infection Control & I Planning Committee Member: 2003 National HIV Infectious Diseases, 2004 Prevention Conference, Atlanta, GA, July 27-30, 2003 I Advisory Board, Clinical Microbiology & Infection, 2003 I Workshop Co-Chair, OAR/CDC Workshop on I Editorial Advisory Board, Infection Control and Improving the Efficacy of HIV Prevention Efforts Hospital Epidemiology, 2004 for MSM, Washington, DC, January 9-10, 2003 I Vice President, Society for Healthcare I Search Committee for Editor-in-Chief, AIDS Epidemiology of America, 2003 Clinical Care, Massachusetts Medical Society. I President-Elect, Society for Healthcare I Faculty Subcommittee for the Liaison Committee Epidemiology of America, 2004 on Medical Education Task Force, Brown Medical 112 School, Brown University brown medical school department of medicine

I Faculty , Society for Healthcare Epidemiology of I Research Committee America and the European Society for Clinical I Fellowship Program Microbiology and Infectious Diseases Training I Grant Reviewer Course in Hospital Epidemiology, Turkey, 2003 & I Freiburg, Germany 2004 K12 Mentored Clinical Research Scholar Award Albert Einstein College of Medicine, Bronx, NY I Faculty, Johns Hopkins U., U. Maryland, U. I Pennsylvania, U. Virginia, Brown U., Wake Forest Loan Repayment Reviewer: NIH/NIDA Special U, and SHEA - Infectious Diseases Fellows Training Emphasis Panel, Extramural Loan Repayment Course, Baltimore, MD 2003 Program, April, 2005. I Planning Committee: 2005 National HIV Prevention Marguerite A. Neill, M.D. Conference, Atlanta, GA, June 12-15, 2005. I Scientific advisor, ILSI North America Technical I Scholarship Reviewer: 2005 National HIV Prevention Committee on Food Microbiology, ILSI Risk Conference, Atlanta,GA, June 12-15, 2005. I Science Institute Steering Committee on the Problem of Listeria monocytogenes in Foods, Washington, DC. Karen T. Tashima, MD I Reviewer, Lifespan Developmental Grant Program Steven M. Opal, M.D I Reviewer, Lifespan/Tufts/Brown CFAR (Center for I The 6th International Congress on the Immune AIDS Research) Consequences of Trauma, Shock and Sepsis, Program Organizing Committee, Munich, Germany, (March 7-11, 2004) TEACHING ACTIVITIES I NIH-National Heart Lung and Blood Institute Program Project Reviews-2003 EDUCATION HONORS

I NIH-Centers for Excellence Regional Grants for Andrew W. Artenstein, M.D. Biodefense Program Reviews-2003 I Dean’s Teaching Excellence Award, presented by I NIH-Cooperative Center Grants for Translational Brown Medical School, July 2004 Research in Biodefense (Chairperson)-2004 I Brown Medical School Department of Medicine I British Medical Research Counsel Review Section- Chairman’s Award for Outstanding Teaching, May Meningitis Research Foundation of the Medical 2005 Research Council-United Kingdom-Ad Hoc Project Review Committee Charles C. J. Carpenter, M.D. I Recipient of the Distinguished Alumnus Award for I Academy of academic fellowships-United Excellence in Career from the class of 1952 at Kingdom-grant application reviewer Princeton University, 2003. I Wellcome Foundation research merit review expert I Recipient of Distinguished Teacher Award from the referee American College of Physicians-American Society I British Society of Antimicrobial Chemotherapy- of Internal Medicine, 2003. external reviewer of research proposals for novel I Recipient of John H. Chafee Leadership in Health anti-inflammatory agents-Basic science division Care Award given by the American Heart Josiah D. Rich, M.D., MPH Association on June 5, 2004. I National Medical Advisory Panel “Evaluating a I Recipient of the W.W. Keen Award. This award is National Model for Viral Hepatitis Training” New given by the Brown Medical Alumni Association in York State Department of Health recognition of his visionary spirit and compassion- I In partnership with the State Office of Alcohol and ate nature as a physician leader and educator, and Substance Abuse for his outstanding contributions to the communi- ty and to society, which represent the best of both I Health Advisory Committee Member Travelers AID clinical and academic medicine. I Grant Peer Reviewer I NIH Comprehensive International Program of E. Jane Carter, M.D. Research on AIDS (CIPRA) (Review of R03 and I Faculty Award – Gold Humanism Award, Brown Medical School Class of 2004 U01 Grant Applications) 113 infectious disease

I Faculty Award. Brown Medical School for teaching I Dean’s Teaching Excellence Award, Brown Medical and contributions to medical Student Education , School, June, 2005 May 2005 Marguerite A. Neill, M.D. Staci A. Fischer, M.D. I Dean’s Teaching Excellence Award for outstanding I Named to America’s Top Physicians, 2003 teaching in Bio 282: Pathophysiology-Infectious I Dean’s Award for Excellence in Teaching, Brown Disease, Brown Medical School I I Medical School, July 2003 Scientific Advisor, Virulence and Pathogenicity of E. sakazakii Project, International Life Science Institute I Chairman’s Award for Outstanding Teaching, I Department of Medicine, Brown Medical School, 2004 Steven M. Opal, M.D. I I Named to “Best Doctors” - Rhode Island/Cape Brown Medical School Department of Medicine Co-edition of Better Living Magazine, 2004 Chairman’s Award for Excellence in Teaching I I Dean’s Award for Excellence in Teaching, Brown Dean’s Teaching Excellence Award Medical School, July 2004 Josiah D. Rich, M.D., MPH Timothy P. Flanigan, M.D. I Associate Director and Chair, CME Course I Brown Medical School Faculty Award for teaching Director, Clinical AIDS Task Force, Brown Brown Medical Students the Art of Serving University AIDS Program Humanity, June 2004 I Expert Panel Member, The University of Texas Medical Branch, School of Medicine, 12th HIV- Joseph I. Harwell, M.D. Related CME Course I Dean’s Teaching Excellence Award, Brown Medical School, Bio 282 Pathophysiology – Infectious Disease TEACHING RESPONSIBILITIES

Michelle A. Lally, M.D. Andrew W. Artenstein, M.D. I Preceptorship Award: “An outstanding teacher in I Teaching Attending Physician, Infectious Disease medicine,” Rhode Island Hospital, The Miriam Consult Service, MHRI Hospital, and Brown University. I Small group leader, Infectious Disease section, Pathophysiology John R. Lonks, M.D. I I Dean’s Teaching Excellence Award. Brown Medical Lecturer, Resident’s Noon Conference, MHRI School. Course Bio351. 2004. I Lecturer, Infectious Disease Fellow’s Lecture Series I Outstanding Clinician, Teacher and Mentor Award. I Preceptor, Clerkship in Medicine, MHRI Awarded by the Infectious Disease Fellows, Brown I Lecturer, Chief’s Rounds, IM House Staff, MHRI Medical School, 2004. I Preceptor, Morning Report, MHRI Kenneth H. Mayer, M.D. I Course Director, “Medicine in the Time of I Dean’s Teaching Excellence Award, Brown Medical Bioterrorism” School, Brown University, Providence, Rhode Island I Guest Lecturer, RI College, Micro 348, “Biodefense for Biodefenders” Leonard Mermel, M.D. I I Dean’s Teaching Excellence Award for BIO 282 Guest Lecturer, Bio 160, “SARS, Monkeypox and Pathophysiology/Infectious Disease, Brown Medical the Next Big Thing” School, 2003, 2004 I Guest Lecturer, RI College, Nursing 370, I Chairman’s Award for Outstanding Teaching, “Biodefense for Biodefenders” Department of Medicine, Brown Medical School, 2003 I Guest Lecturer, URI, MTC 591, “Biodefense for I Infectious Disease Fellow’s Recognition Award for Biodefenders” Excellence in Teaching, Brown Medical School, 2004 Charles C.J. Carpenter, M.D. Maria D. Mileno, M.D. I The Miriam Hospital; Preceptor, Morning Report 4 I America’s Top Physician Award, August 2003 days per week I I Dean’s Teaching Excellence Award, Brown Medical The Miriam Hospital; Preceptor of interns once a week 114 School, June 2004. brown medical school department of medicine

I The Miriam Hospital; Core Medical Clerkship once I Internal Medicine Ward Attending a week I Lecturer at The Miriam Hospital on clinical mani- I Brown Medical School-wide Infectious Diseases festations of HIV/AIDS. Third year medical stu- Conference: HIV Update, 2003 and 2004 dents during the core of Medical Clerkship

E. Jane Carter, M.D. Mary M. Flynn, Ph.D. I Director, Brown-Moi Medical Exchange Program I Principles of Nutrition, Brown University I Visiting Professor, Moi University School of I Diet and Chronic Diseases, Brown University Medicine, Eldoret, Kenya Melissa Gaitanis, M.D. I Preceptor, Tuberculosis Clinic House Staff I Teaching Attending Physician, Infectious Disease Conference Series: Tuberculosis, Diagnosis and Consult Service Management I Teaching Attending Physician, Rhode Island I House Staff Conference Series: The Miriam Hospital HIV Clinic Hospital/RIH/VAMC 2 lecture series on tuberculo- I sis (active and latent) Co-Director, Brown Medical School Pathophysiology Course in Infectious Disease I Pulmonary and Critical Care Fellowship Program, I Brown University: Introductory lecture series: Lecturer, Brown Medical School Pathophysiology Tuberculosis, Diagnosis and Management Course in Infectious Disease I Lecturer, Resident’s Noon Conference Patricia Cristofaro, M.S. I Lecturer, Infectious Disease Fellow’s Lecture Series I Teaching Rounds VA Hospital currently attending I 2005 Co-Director, Brown Medical School Susan Cu-Uvin, M.D. Pathophysiology Course in Infectious Disease I ACTG Summer Conference, “Training Session on Genital Secretions Collection Methods”, Joseph I. Harwell, M.D. I Washington, D.C. August 2, 2004. Biomed 282, Pathophysiology of Infectious Diseases - small group sessions I HPTN Centralized Training Session, “Training I Session on Genital Secretions Collection Methods”, Guest lecturer for BC 34, Health and Human Washington, D.C., October 6, 2004 Reproduction: “Sexually transmitted diseases in the developing world” Staci A. Fischer, M.D. I Immunology consult service teaching attending I Teaching Attending Physician, Infectious Disease I Adult and Pediatric Infectious Diseases consult Consult Service service teaching attending I Small group leader, Infectious Disease section, I Pediatric HIV clinic teaching attending Pathophysiology. I Infectious Diseases weekly conference - “National HIV I Lecturer, Resident’s Noon Conference prevention programs that work”,“HIV in Cambodia, I Lecturer, Infectious Disease Fellow’s Lecture Series epidemiology, clinical care, and research findings” I Lecturer, Trauma Surgery, Nephrology, Medicine I Infectious Diseases Journal Club monthly meeting Fellowships and Residencies I Medical teaching attending – Med A service I Chicago Infectious Disease Board Review course I Weekly morbidity and mortality conference presenter I Clinical Nephrology Board Review course I House staff noon conference – Antibiotics 1 and 2 Timothy P. Flanigan, M.D. I Bimonthly Infectious Diseases core curriculum I Small group leader, Infectious Disease section, lecture series – Antibiotics 1 and 2 Pathophysiology. Second year medical students Michelle A. Lally, M.D., MSc I Lecturer, HIV infection in the developing world, I Mentor, Summer Research Assistantships, 2003 UC107 I Organizer, special session for second year medical John R. Lonks, M.D. students during the Pathophysiology course to I Director, Bio 351, Integrated Medical Sciences meet and speak with persons with AIDS 115 infectious disease

I Pathophysiology of Infectious Diseases and I Doctoral thesis advisor and committee member for Pharmacology of Anti-infective agents. Brown six graduate students in either Community Health Medical School. Small group leader. Bio 351.1, (Brown), or Epidemiology or Immunology and Integrated Medical Sciences, Pathophysiology of Infectious Disease (Harvard School of Public Health) Infectious Diseases I Director, Medical Student Senior Seminar: Lessons I Lecturer, Bio 351.1, Bone and Joint Infections of AIDS, Brown University I Lecturer, Bio 351.2: Organ System Pharmacology. I Faculty for University of Rhode Island’s Virology “Antibacterial Agents Parts I and II” course, lecture on “HIV/AIDS.” I Teaching Attending Physician, General Internal Leonard A. Mermel, D.O. Medicine, Miriam Hospital/Brown Medical School I Small Group Leader, IMS 282/Infectious Disease I Casebook discussion leader. BI0301 Miriam Pathophysiology , 2003, 2004 Hospital/Brown Medical School. I Small Group Leader, BIO 158/Medical I Instructor, Gram stain review. BIO301 Brown Microbiology, 2003, 2004 Medical School I Teaching Attending Physician, Internal Medicine, 2003 I Course Leader, Miriam Hospital, BIO307 Elective I Lecturer, Resident’s Noon Conference, 2003, 2004 clinical rotation in Infectious Diseases. I Lecturer, Critical Care, Hematology/Oncology I Lecturer, Brown-wide Infectious Diseases Fellowships; Emergency Medicine, Pediatrics, Conference, topics (e.g. rabies, macrolide resistant Neurosurgery Residencies, 2003, 2004 pneumococci, post-sternotomy infections) I Preceptor, Biomed 301, Clerkship in Medicine, Maria D. Mileno, M.D. Miriam Hospital/Brown Medical School I Faculty Leader, Alternative Healing and Complementary Medicine Affinity Group, with Dr. I Morbidity and Mortality Conference, Department of Medicine, Miriam Hospital James Burrill I Small group leader and lecturer, Infectious Disease I Lecturer, Housestaff and medical student Noon time conference (meningitis, community acquired Pathophysiology course pneumonia, animal bites, introduction to Infectious I Immunology Center & Travel Medicine elective Diseases (antibiotics), rabies, bone and joint infec- rotation tions, smallpox vaccination, fever and neutropenia) I Course Leader with Dr. Timothy Flanigan: Tropical I Bimonthly Infectious Diseases core curriculum Topics Elective: Introduction to Tropical Medicine, lecture series – Antibiotics 1 and 2 Brown Medical School, February 2005

I Lecturer, Infectious Disease Fellows Didactic Lecture Marguerite Neill, M.D. I Bimonthly Infectious Diseases core curriculum I Course Leader, Pathophysiology of Infectious lecture series – Antibiotics 1 and 2 Diseases, Brown Medical School, 1997-2004 I Research preceptor, Adult and Pediatric Infectious I Lecturer and small group leader, Pathophysiology of Disease Fellows. Infectious Diseases, Brown Medical School 1989-2005

I Kenneth H. Mayer, M.D. Teaching Attending, Internal Medicine Program, Memorial Hospital I Multiple annual lectures to undergraduates; first and second year Brown University Medical I Teaching Conference lecturer, Family Medicine and Students on: Internal Medicine Programs, Memorial Hospital 1. Pharmacology and Mechanisms of Action of I Morbidity and Mortality Conference Discussant, Antibiotics Memorial Hospital 2. Antibiotic Resistance I Preceptor, Monthly Infectious Disease Fellows’ 3. Epidemiology, Clinical Manifestations and Journal Club Treatment of HIV/AIDS Steven M. Opal, M.D. I Teaching attending for fellows, residents, medical students 116 brown medical school department of medicine

Josiah D. Rich, M.D. I Co-Course Leader Integrated Pathophysiology : I Preceptor, Brown Medical School and Lifespan Infectious Diseases Academic Medicine Center I Teaching Attending Physician, Infectious Disease I Internal Medicine Community Based Teaching Consult Service, TMH Program I Small group leader, Infectious Disease section, I Mentor, Community Based Teaching Program Pathophysiology I Brown Medical School, Residency Programs in I Lecturer, Infectious Disease Fellow’s Lecture Series Medicine I Preceptor, Clerkship in Medicine, Brown Medical School I Mentor: Community Health Clerkship Lynn E. Taylor, M.D. I Brown Medical School I Preceptor, Brown Medical School, Hepatitis C I Educator: Brown Medical School, The Center of Clerkship Excellence in Women’s Health, Research Core I Preceptor, Brown Medical School, Infectious Mentoring Program for Junior Investigators, Disease Elective “HIV/HCV Coinfection” “Substance Abusing Populations”. I Mentor, Brown Medical School Office of Women in Karen T. Tashima, MD Medicine I Director, Infectious Disease Fellowship Training I Teaching of GI and ID fellows, residents and medical Program, Brown Medical School students in Immunology Center I Fellows Preceptor in weekly Infectious Disease/HIV I Lecturer, Housestaff and medical student noon time clinic conference (viral hepatitis, antiretroviral medications) I Co-Director of Internal Medicine Senior Residents I Lecturer, Infectious Disease Fellows Didactic Lecture Research

INFECTIOUS DISEASE FELLOWSHIP PROGRAM

Departing Fellows

Name Medical School Residency Patricia Cristofaro, M.D. Boston University Brown Medical School Joao Tavares, M.D. University of Coimbra, Portugal Brown Medical School Brenda Urbina, M.D. University of Puerto Rico Norwalk Yale

Current Fellows

Name Medical School Residency Curt Beckwith, M.D. Dartmouth/Brown Program in Medicine Brown Medical School Husam Issa, M.D. Jordan University Scranton-Temple Troy Martin, M.D. University of Washington Brown Medical School Michael Poshkus, M.D. Columbia University Brown Medical School Arathi Rao, M.D. Kasturba Medical College Western Reserve Hospital, Ohio Manalo Rosario, M.D. University of East Quezon City, Philippines Brown Medical School Current NIH T32 Sponsored Research Fellows

Name Medical School Residency Abigail Harrison, Ph.D. University of London N/A Miriam Haverkamp, M.D. Hochschule Hannover, Germany Montefiore Medical Center Shannon Moore, M.D. Jackson State University Ph.D. candidate in Psychology David Tate, Ph.D. Brigham Young N/A Lynn E. Taylor, M.D. University of Pittsburgh Brown Medical School

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SELECTED PUBLICATIONS I Yeni PG, Hammer SM, Hirsch MS, Saag MS, Schechter M, Carpenter CCJ, Fischl MA, Gatell JM, Gazzard BG, Andrew W. Artenstein, MD Jacobsen DM, Katzenstein DA, Montaner JSG, I Artenstein AW. Bioterrorism and Biodefense. In: Richman DD, Schooley RT, Thompson MA, Vella S, Cohen J, Powderly WG, eds. Infectious Diseases, Volberding PA. Treatment for adult HIV infection. second edition. Mosby: London, 2003:99-107. 2004 recommendations of the International AIDS Society-USA panel. JAMA 292(2):251-65, 2004 I Artenstein AW. Investigation of a Smallpox Outbreak. In: Cohen J, Powderly WG, eds. Infectious Diseases, E. Jane Carter, M.D. second edition. Mosby: London, 2003:1022-1024. I A. Kwara, E.J.Carter, J. Rich, T. Flanigan. Development Artenstein AW. Smallpox Vaccination. N Engl J Med of Opportunistic Infections after Diagnosis of Active 2003;348:1925 Tuberculosis in HIV infected patients. AIDS Patient I Artenstein AW, Johnson C, Marbury TC, et al. A Care and STDs. 2004 Vol 18 No 6 pp341-347. novel, cell culture-derived smallpox vaccine in I J. Cohen, S. Kimaiyo, W. Nyandiko, A. Siika, K. Wools- vaccinia-naïve adults. Vaccine 2005;23:3301-9. Kalustian, J. Mamlin, and E. J. Carter. Addressing the I Opal SM, Artenstein AW, Cristofaro PA, Jhung JW, Educational Void During the antiretroviral rollout. Palardy JE, Parejo NA, Lim Y-P. Inter-alpha Inhibitor AIDS.2004, 18:2105-6. (Correspondence) Proteins are endogenous furin inhibitors and provide I A. Kwara, E. J. Carter, T. Flanigan. Highly Active protection against experimental anthrax intoxication. Antiretroviral Therapy (HAART) in Adults with Infect Immunity 2005:73(8):5101-05. Tuberculosis: Current Status. Int J Tuberc Lung Dis I Artenstein AW. Book Review: Physician’s Guide to 9(3):248-257. Terrorist Attack. International Journal of Infectious Patricia Cristofaro, M.D. Diseases, 2004;8:382-3. I Cristofaro P, Opal S. The toll-like receptors and Charles C.J. Carpenter, MD their role in septic shock. Expert Opinion on I Jones CY, Hogan J, Snyder B, Klein RS, Rompalo A, Therapeutic Targets, 2003 Oct; 7(5):603-12. Schuman P, Carpenter CCJ for the HIV Epidemiology I Cristofaro P. Infection and fever in the elderly. J Am Research Study Group. Overweight and human Podiatr Med Assoc 2004 March/April;94(2):126-34. immunodeficiency virus (HIV) progression in I Cohen J, Cristofaro P, Opal S, Carlet J. A new method women: Associations HIV disease progression and of classifying infections in critically ill patients, changes in body mass index in women in the HIV Critical Care Medicine, 2004 July;32(7):1510-26. epidemiology research study cohort. Clin Inf Dis I Artenstein A, Opal S, Cristofaro P, et al, Chloroquine 37:S69-80, 2003. enhances survival in Bacillus anthracis intoxication. J I Mayer KH, Hogan JW, Smith D, Klein RS, Schuman Infect Dis, 2004 Nov 1;190(9):1655-60. P, Margolick JB, Korkontzelou C, Farzedegan H, I Cristofaro P. Prophylactic antibiotics for animal bites. Vlahov D, Carpenter CCJ. Clinical and immunolog- Chapter 96e in the textbook Cohen & Powderly, ic progression in HIV-infected US women before Infectious Diseases, 2nd edition, Elsevier 2004. and after the introduction of highly active anti- retroviral therapy. JAIDS 33:614-24, 2003. Susan Cu-Uvin, MD I Gardner LI, Holmberg SD, Williamson JM, Szczech I Harwell JI, Moench T, Mayer KH, Chapman S, LA, Carpenter CCJ, Rompalo AM, Schuman P, Rodriguez I, Cu-Uvin S. A pilot study of treatment Klein RS. Development of proteinuria or elevated of bacterial vaginosis with a buffering vaginal serum creatinine and mortality in HIV-infected microbicide. J Women’s Health 12: 255-259, 2003. women. JAIDS 32:203-9, 2003. I DePasquale MP, Brown AJL, Cu-Uvin S, Ingersoll J, I Mahajan AP, Hogan JW, Snyder B, Kumarasamy N, Caliendo A, Sutton L, Donahue S, D’Aquila R. Mehta K, Solomon S, Carpenter CCJ, Mayer KH, Differences in HIV-1 pol sequences from female Flanigan TP. Changes in total lymphocyte count as genital tract and blood during antiretroviral therapy. a surrogate for changes in CD4 count following ini- J Acquir Immune Defic Syndr 34:37-44, 2003. tiation of HAART: Implications for monitoring in resource-limited settings. JAIDS 36:567-75, 2004.

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I Harwell J, Flanigan TP, Mitty J, Macalino G, I Jennifer A. Mitty, MD, MPH, Grace E. Macalino, PhD, Caliendo A, Ingersoll J, Stenzel M, Carpenter CCJ, Lauri B. Bazerman, MS, Helen G. Loewenthal, MSW, Cu-Uvin S. Directly observed antiretroviral therapy Joseph W. Hogan, ScD, Cynthia J. MacLeod, ACRN, to reduce genital tract and plasma HIV-1 RNA in and Timothy P. Flanigan, MD, The Use of Community- women with poor adherence. AIDS 17:1990-3, 2003. Based Modified Directly Observed Therapy fo the I Natividad-Villanueva G, Santiago E, Manalastas R, Treatment of HIV-Infected Persons, J Acquir Immune Brown HW, Ingersoll J, Caliendo AM, Mayer KH, Defic Syndr, Volume 39, Number 5, August 15, 2005 Cu-Uvin S. Human immunodeficiency virus in the Joseph I. Harwell, M.D. plasma and cervicovaginal secretions in Filipino I Harwell JI, Moench T, Mayer KH, Chapman S, women. Internat J STD & AIDS 14: 826-9, 2003. Rodriguez I, Cu-Uvin S. A pilot study of treatment I Theng T, Phan S, Pugatch D, Harwell J, Rufner KM, of bacterial vaginosis with a buffering vaginal Chhi Mean V, Mayer KH, Cu-Uvin S. HIV-1 cord- microbicide. Women’s Health and Gender Based blood seroprevalence of parturient women in Medicine 12:255-9, 2003. Sihanoukville, Cambodia. Internat J of STD & AIDS I Chhin S, Rozycki G, Pugatch D, Harwell JI. Etiology 15:419-21, 2004. of Meningitis in HIV-Infected Patients in a Referral Staci A. Fischer, M.D. Hospital in Phnom Penh, Cambodia. Internat J I Poshkus M, Fischer SA. Hepatitis B: New Options in STD & AIDS 15:48-50, 2004. Diagnosis and Treatment. Medicine and Health/Rhode I Theng T, Sok P, Pugatch D, Harwell JI, Ruffner, KM, Island 86(6):170-3, 2003. Chhi Mean V, Mayer KH, Cu-Uvin S. HIV preva- I Urbina, BY, Gohh, R, Fischer SA. Oerskovia xanthi- lence among parturient women in Sihanoukville, neolytica Endocarditis in a Renal Transplant Cambodia. Internat J STD & AIDS 15:419-21, 2004. Patient: Case Report and Review of the Literature. I Flanigan TP, Campbell T, Harwell J, Kumarasamy Transplant Infectious Disease 5:195-8, 2003. N. The extraordinary hope of antiretroviral therapy I Fischer SA, Harris AA. Brain abscess. In: Infectious in South Africa (even for patients with tuberculosis Diseases (3rd ed). Gorbach SL, Bartlett JG, Blacklow and Kaposi’s sarcoma!). J Infect Dis NR (eds.), WB Saunders, Philadelphia, 2003. I Harwell J, Cu-Uvin, S. Measuring HIV in the female genital tract and how this affects sexual and Timothy P. Flanigan, M.D. reproductive choices. Harvard Health Policy Review I Rich JD, Ching CG, Lally MA, Murphy MA, Spring 2005. Schwartzapfel B, Charuvastra A, Beckwith C, Flanigan TP.A review of the case for hepatitis B vaccination of Rami Kantor, M.D. high-risk adults. Am J Med 114:316-8, 2003. I M Gonzales, TD Wu, J Taylor, I Belitskaya, R Kantor, I Mahajan AP, Hogan JW, Snyder B, Kumarasamy N, D Israelski, S Chou, A Zolopa, WJ Fessel, RW Shafer. Mehta K, Solomon S, Carpenter CCJ, Mayer KH, Extended spectrum of HIV-1 reverse transcriptase Flanigan TP. Changes in total lymphocyte count mutations in patients receiving multiple nucleoside (TLC) as a surrogate for changes in CD4 count analog inhibitors. AIDS 2003; 17: 791-9. following initiation of HAART: Implications for I TD Wu, CA Schiffer, M Gonzales, J Taylor, R monitoring in resource-limited settings. J AIDS Kantor, S Chou, D Israelski, A Zolopa, JW Fessel, 36(1): 567-575, 2004. RW Shafer. Mutation Patterns and Structural I Flanigan TP, Mitty JA, Macalino GE, Guest Editors. Correlates in HIV-1 Protease Following Varying Directly observed therapy and other community- Degrees of Protease Inhibitor Treatment. Journal of Based Efforts to Improve Adherence to HAART. Clin Virology 2003; 77: 4836-47. Inf Dis Supplement 38 (Suppl 5):S373-436, 2004. I R Kantor, D Katzenstein. Drug resistance in non- I Beckwith CG, MD, Flanigan TP, del Rio C, MD, subtype B HIV-1. Journal of Clinical Virology Simmons E, Wing EJ. It Is Time to Implement 2004;29:152-9. Routine, Not Risk-Based, HIV Testing. Clin Infect I R Kantor, S Follansbee, RW Shafer, J Taylor, D Shilane, Dis 4(7):1037-1040, 2005. L Hurley, DP Nguyen, D Katzenstein, WJ Fessel. Evolution of drug resistance in HIV-1 among persons failing antiretroviral therapy. AIDS 2004;18:1503-11. 119 infectious disease

I O Akinsete, D Hirigoyen, C Cartwright, R Schut, R Steven P. LaRosa, M.D. Kantor, K Henry. K103N mutation in antiretroviral I Opal SM, Garber GE, LaRosa SP, Maki DG, therapy (ART) naïve African patients infected with Freebairn RC, Kinasewitz GT, Dhainaut JF, Yan B, HIV-1. Clinical Infectious Diseases 2004; 39:575-8. Williams MD, Graham DE, Nelson DR, Levy H and Bernard G. Systemic host responses in severe sepsis Awewura Kwara, M.D. analyzed by causative microorganism and treat- I Kwara A, Schiro R, Cowan LS, Hyslop NE, Wiser MF, ment effects of drotrecogin alfa (activated). Clin Roahen HS, Kissinger P, Diem L, Crawford JT. Infect Dis 37:50-8, 2003. Evaluation of the epidemiologic utility of secondary I Dhainaut JF, Laterre PF, LaRosa SP, Levy H, Garber typing methods for differentiation of Mycobacterium GE, Heiselman D, Kinasewitz GT, Light RB, Morris, tuberculosis isolates. J Clin Miocrobiol 41:2683-5, 2003. P, Schein R, Sollet, JP, Bates BM, Utterback BG, I Kwara A, Carter EJ, Rich JD, Flanigan TP. Maki D. The clinical evaluation committee in a Development of opportunistic infections after diag- large phase 3 trial of drotrecogin alfa (activated) in nosis of active tuberculosis in HIV-infected patients. patients with severe sepsis (PROWESS). Crit Care AIDS Patient Care and STDS 18:341-7, 2004. Med 31:2291-2301, 2003. I Kwara A, Flanigan TP, EJ Carter. Highly active anti- •I Kalil AC, Coyle SM, Um JY, LaRosa SP, Turlo MA, retroviral therapy (HAART) in adults with tuberculo- Calvano SE, Sundin DP, Nelson DR, Lowry SF. sis: current status. Int J Tuber Lung Dis 2005;9:248-257. Effects of drotrecogin alfa (activated) in human I Kwara A, Roahen Harrison S, Prystowsky E, Kissinger endotoxemia. Shock 21 (3):222-9, 2004. P, Mathison J, Adams R, Hyslop NE. Manifestations I LaRosa SP, Opal SM. Clinical trials of novel antico- and outcome of extrapulmonary tuberculosis: impact agulants for severe sepsis: A tale of three molecules. of human immunodeficiency virus coinfection. Int J Advances in Sepsis 4(1):17-23, 2004. Tuber Lung Dis 2005;9:485-493. I LaRosa SP, Opal SM. Tissue Factor Pathway Michelle A. Lally, M.D. Inhibitor and Antithrombin Trial Results. Crit Care I Simmons E, Lally MA, Flanigan TP. Routine, not Clin 2005; 21:433-448. risk-based, human immunodeficiency virus testing John R. Lonks, M.D. is the way to go. (Correspondence) J Infect Dis I Lonks JR, Medeiros AA, Garau J, Gareen IF. Reply 187(6):1024, 2003. to: A testament to sustained macrolide efficacy. Clin I Rich JD, Ching CG, Lally MA, Murphy MA, Infect Dis 36(7)936-7, 2003. Schwartzapfel B, Charuvastra A, Beckwith CG, I Lonks JR. What is the clinical impact of macrolide Flanigan TP. A review of the case for hepatitis B. resistance? Current Infectious Disease Reports 6(1):7- Vaccination of high-risk adults. Am J Med 114:316- 12, 2004. 8, 2003. I File TM Jr, Garau J, Blasi F, Chidiac C, Klugman K, I Beckwith CG, Simmons E, Lally MA, Flanigan TP. Lode H, Lonks JR, Mandell L, Ramirez J, Yu V. Testing for HIV infection: Should it be routine? Special Report. Guidelines for empiric antimicrobial Resident & Staff Physician 50(4):9-15, 2004. prescribing in community-acquired pneumonia. I DeGroot AS, Bishop EA, Khan B, Lally MA, Marcon Chest 125(5):1888-1901, 2004. L, Franco J, Mayer KH, Carpenter CCJ, Martin M. I Klugman, KP and Lonks JR. Perspective: Hidden Engineering immunogenic consensus T helper epi- epidemic of macrolide - resistant pneumococci. topes for a cross-clade HIV vaccine. Methods Emerging Infectious Disease, 2005 June;11(6):802-7. 34(4):476-87, 2004. I Lonks JR, Goldmann DA. Special Section: Reviews I Lally MA, MacNevin R, Sergie Z, Hitt R. DiSpigno M. of anti-infective agents. Telithromycin, a Ketolide Cenedella C, Stein MD. A model to provide compre- Antibiotic for Treating Respiratory Tract Infections hensive testing for HIV, viral hepatitis, and sexually Telithromycin. Clinical Infectious Diseases 2005, transmitted infections at a short-term drug treatment June 1;40(11)1657-64. center. AIDS Patient Care & STDs 19(5):298-306, 2005.

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Kenneth H. Mayer, M.D. catheter-related infections. In: Seifert H, Jansen B, I Mayer KH, Hogan JW, Smith D, Klein RS, Schuman P, Farr B, eds. Catheter Related Infections (2nd ed), Margolick JB, Korkontzelou C, Farzedegan H, Vlahov Marcel Dekker, New York, 2005, pp 379-424. D, Carpenter, CCJ for the HIV Epidemiology Research Study (HERS) Group. Clinical and Maria D. Mileno, M.D. I immunologic progression in HIV-Infected US women Mileno MD. Immunizations. In: Educational Review before and after the introduction of highly active Manual in Infectious Disease. Cunha, Burke Ed. antiretroviral therapy. JAIDS 33(5):614-24, 2003. Castle Conolly Medical Publishing, Wayne, NJ, 2003. I Mirza H, Cross S and Mileno MD. First Case of I Kumarasamy N, Solomon S, Chaguturu SK, Mahajan AP, Flanigan TP, Balakrishnan P, Mayer West Nile Infection in Rhode Island. Medicine KH. Safety, tolerability and effectiveness of generic Health Rhode Island, June 2003. antiretroviral drug regimens for HIV-infected I Mileno MD. Immunocompromised Travelers. In: patients in South India. AIDS 17(15):2267-9, 2003. Travel Medicine. Keystone, T ed. Elsevier Health Sciences, 2004. I Koblin B, Chesney M, Coates T, Husnik M, Beauchamp G, Huang Y, Bozeman S, Madison M, I Rao A and Mileno MD. Immunization Schedules and Buckbinder S, Celum C, Colfax G, Judson F, Mayer K, Recommendations. In: Handbook of Bioterrorism McKirnan D for the EXPLORE Study Team. Effects and Disaster Medicine, edited by John D. Cahill, M.D. of a behavioral intervention to reduce acquisition of and Robert Antosia, M.D. Springer, New York, 2005. HIV infection among men who have sex with men: I Suh KN and Mileno MD. Challenging Scenarios in the EXPLORE randomized controlled study. The a Travel Clinic: Advising the Complex Traveler. Lancet 364:41-50, 2004. Infectious Disease Clinics of North America. 2005, I Mayer, KH, Safren SA, Gordon CM. HIV Care 19:1, 15-47. Providers and Prevention. JAIDS 2004; 37:S130-132. Jennifer A. Mitty, M.D. I Kumarasamy N, Vallabhaneni S, Flanigan TP, I Harwell JI, Cu-Uvin S, Mitty JA, Macalino GE, Balakrishnan P, Cecelia A, Carpenter CCJ, Solomon Stenzel M, Carpenter CCJ, Flanigan T, Directly S, Mayer KH. Rapid Viral Load Suppression Observed Antiretroviral Therapy to Reduce Genital Following Generic Highly Active Antiretroviral Tract and Plasma HIV-1 RNA in Women with Poor Therapy in Southern Indian HIV-infected Patients. Adherence. AIDS 2003; 17(13):1990-3. AIDS 19(6):625-627, 2005. I Jennifer Adelson Mitty, Timothy P. Flanigan Leonard A. Mermel, D.O. Community-Based Interventions for Marginalized I Mermel LA, McKay M. Dempsey J, Parenteau S. Populations Clin Infect Dis 2004:38 (Supple 5) Pseudomonas surgical site infections linked to a S373-375 healthcare worker with onychomycosis. Infect I Macalino GE, Mitty JA, Bazerman LB, Singh K, Control Hosp Epidemiol 24: 749-752, 2003. McKenzie M, Flanigan TP. Modified directly observed I Savinelli T, Parenteau S, Mermel LA. What happens therapy (DOT) for the treatment of HIV seropositive when automated blood culture instruments detect substance users: Lessons learned from a pilot study. growth but there are no technologists in the micro- Clin Infect Dis 38 Suppl 5:S393-7, 2004 biology laboratory? Diag Microbiol Infect Dis I Arlene The1, Jennifer A. Mitty MD, MPH2, Helen 48:173-174, 2004. Loewenthal MSW2, Lauri B. Bazerman MS2, I Dietrich DW, Auld DB, Mermel LA. Community- Timothy Flanigan MD2, The Potential Use of acquired methicillin-resistant Staphylococcus aureus Directly Observed Therapy (DOT) for the Treatment in southern new england children. Pediatrics of HIV+ Individuals Being Released from Prison. 113:e346-e351, 2004. Journal of Correctional Health; Vol. 11, Issue 2 I Wong, ES, Rupp, ME, Mermel LA, Perl TM, Bradley I Jennifer A. Mitty, MD, MPH, Grace E. Macalino, PhD, S, Ramsey KM, Ostrowsky B, Valenti AJ, Jernigan Lauri B. Bazerman, MS, Helen G. Loewenthal, MSW, JA, Voss A, Tapper M. Public Disclosure of Joseph W. Hogan, ScD, Cynthia J. MacLeod, ACRN, Healthcare-Associated Infections: The Role of the and Timothy P. Flanigan, MD, The Use of Community- Society for Healthcare Epidemiology of America. Based Modified Directly Observed Therapy fo the Infect Control Hosp Epidemiol 26:210-212, 2005. Treatment of HIV-Infected Persons, J Acquir Immune Defic Syndr, Volume 39, Number 5, August 15, 2005 I Mermel LA, Farr BM. Management of intravascular 121 infectious disease

Marguerite A. Neill, M.D. Bharat Ramratnam, M.D. I Bioterrorism Information and Resources for I Boden, D., Pusch, O., Lee, F., Tucker, L., Clinicians. Available at: http://www.idsociety.org Ramratnam, B. (2003) HIV-1 escape from RNA [M A Neill as contributor and editor to this section interference. Journal of Virology 77: 11531-11535. of the IDSA website for 2003 and 2004] I Ramratnam, B., Ribeoro, R., He, T., Chung, C., Simon, I Neill MA, Carpenter CCJ. Other pathogenic vibrios. V., Vanderhoeven, J., Hurley, A., Zhang, L., Perelson, In: Principles and Practice of Infectious Disease. 6th A.S., Ho, D.D., Markowitz, M. (2004) Intensification Edition GL Mandell, JE Bennett, R Dolin, eds. of antiretroviral therapy accelerates the decay of the Churchill Livingstone. Philadelphia PA 2004:2544-48. HIV-1 ltent reservoir and decreases but does not I Neill MA. Bloodborne pathogens education: once eliminate ongoing virus replication. JAIDS 35:33-37. more with feeling! Medicine Health RI 2003;86:160- I Pusch, O., Boden, D., Silbermann, R., Lee, F., Tucker, 178. [Neill MA guest editor for the entire June issue L., Ramratnam, B. (2004). Enhanced gene silencing on bloodborne pathogens pg 161-78]. of HIV-1 specific siRNA using microRNA designed I Klein EJ, Stapp JR, Neill MA, Besser JM, Osterholm hairpins. Nuclei Acids Research 32:1154-58. MT, Tarr PI. Shiga toxin antigen detection should I Newstein M., Losikoff, P., Caliendo, A., Ingersoll, J., not replace sorbitol MacConkey agar screening of Kurpewski, J., Hanley, D., Cerezo, J., Ramratnam, stool specimens. J Clin Microbiol 42:4416, 2004. B., Cu-Uvin, S. Prevalence and persistence of mon- I Dundas S, Neill MA, Todd A, Tarr PI. Antibiotics nucleoside reverse transcriptase inhibitor mutations and Escherichia coli O157:H7 Infections BMJ in the female genital tract. J Acquir Immune Defic 2005;330:1209 Syndr. 2005 Mar 1:38(3):364-6. I Balakrishnan-P., Kumarasamy, N., Solomon, S., Steven M. Opal, M.D. Vidya, S., Kantor, R., Mayer, K., Newstein, M., I Opal SM, Keith JC, Jr., Jhung, J, Palardy JE, Parejo Thyagarajan, S.P., Katzenstein, D., Ramratnam, B. N, Marchese E, Maganti V. Orally administered HIV-1 genotypic variation in an antiretroviral recombinant human interleukin-11 is protective in treatment naïve population in South India. AIDS experimental neutropenic sepsis. The Journal of Res Hum Retroviruses. 2005 Apr:21(4):301-5. Infectious Diseases 2003; 187:70-76. I Opal SM, Maki D, LaRosa, S, Garber G, Dhainaut JF, Josiah D. Rich, M.D., MPH Graham D, Freebairn R, Bernard G. Systemic host I Allen SA, Spaulding AC, Osei AM, Taylor LE, response to sepsis based upon the infection microor- Cabral AM, Rich JD. Treatment of chronic hepatitis ganism and effects of drotrecogin alfa activated. C in a state correctional facility. Ann Int Med Clinical Infectious Diseases 2003; 37:50-58. 138(3):187-90, 2003. I I Opal SM, Laterre P-F, Abraham E, Francois B, Rich JD, Ching CG, Lally MA, Murphy MA, Wittebole X, Warren B, Dugernier T, Dhainaut J-F, Schwartzapfel B, Charuvastra A, Beckwith CG, Lopez A, Sanchez M, Demeyer I, Jauregui L, Lorente Flanigan TP. A review of the case for hepatitis B JA, McGee W, Reinhart K, Kljucar S, Lowry S, Souza vaccination of high-risk adults. Am J Med S, Pribble J, and the (COMPASS) Investigators. 114(4):316-8, 2003. Recombinant human platelet-activating factor I Rich JD, McKenzie M, Macalino GE, Taylor LE, acetylhydrolase for the treatment of severe sepsis: Sanford-Colby S, Wolf F, McNamara S, Mehrotra M, Results of a Phase III, multicenter, randomized, Stein MD. A syringe prescription program to prevent double-blind, placebo-controlled, clinical trial. infectious disease and improve health of injection Critical Care Medicine 2004; 32(2):332-341. drug users. J Urban Health 81(1):122-34, 2004. I Opal, SM. The Concept of PIRO as a new conceptual I Macalino GE, Vlahov D, Sanford S, Patel S, Sabin K, framework to understand sepsis. Pediatric Critical Salas C, Rich JD. Prevalence and incidence of human Care Medicine 2005; 6: S55-S60. immunodeficiency virus, hepatitis B virus and hepa- I Opal SM, Artenstein A, Cristofaro PA, Jhung J, titis C virus infections among males in Rhode Island Palarady JE, Parejo NA, Lim Y-P. Inter-alpha prisons. Am J Pub Health 94(7):1218-23, 2004. Inhibitor proteins are endogenous furin inhibitors I Rich JD, Boutwell AE, Shield DC, Key RG, McKenzie and are protective in experimental anthrax intoxica- M, Clarke JG, Friedmann PD. Attitudes and prac- tion. Infection and Immunity 2005;73(8):5101-5105. tices regarding the use of methadone in US state 122 and federal prisons. J Urban Health 82:411-19, 2005. brown medical school department of medicine

Emma M. Simmons, M.D. TC, Holmberg SD. Rates and risk factors for overall I Beckwith C, Simmons EM, Lally M, and Flanigan T. and medical condition-associated hospitalizations in Testing for HIV Infection: Should It Be Routine? HIV-infected women. J AIDS 34(3):320-30, 2003. Resident and Staff Physician. 2004; 50(4): 9-15. I Dube MP, Stein JH, Aberg JA, Fichtenbaum CJ, I Simmons EM, Monroe A, Flanigan TP. Testing for Gerber JG, Tashima KT, Henry KW, Currier JS, HIV to destigmatize and improve HIV diagnosis. Sprecher D, Glesby MJ. Guidelines for the evaluation Clin Inf Dis 39(8):1259-60, 2004. and management of dyslipidemia in human immun- I Simmons EM, Rogers M, Beckwith C, Frierson G, odeficiency virus (HIV)-infected adults receiving and Flanigan T. Racial/Ethnic Attitudes towards antiretroviral therapy: Clin Infect Dis 37:613-27, 2003. HIV Testing in the Primary Care Setting. J of Nat I Bausserman LL, Tashima KT, DiSpigno M, Maceroni Med Assoc. 2005; 97(1): 46-52. D, Carpenter CCJ. Racial differences in serum lipids I Beckwith C, Flanigan T, del Rio C, Simmons EM, in HIV + women treated with protease inhibitor Wing E, Carpenter C.J. and Bartlett J. It’s Time to regimens. HIV Clinical Trials 5(6):399-405, 2004. Implement Routine, not Risk-Based, HIV Testing. I Gupta SK, Eustace JA, Winston JA, Boydstun II, Clin Inf Dis. 2005; 40: 1037-40. Ahuja TS, Rodriguez RA, Tashima KT, Roland M, Franceschini N, Palella FJ, Lennox JL, Klotman PE, Karen T. Tashima, M.D. Nachman SA, Hall SD, Szczech LA. Guidelines for I Tate D, Paul RH, Flanigan TP, Tashima KT, Nash J, the Management of Chronic Kidney Disease in Adair C, Boland R, Cohen RA. The impact of apathy HIV-Infected Patients: Recommendations of the and depression on quality of life in patients infected HIV Medicine Association of the Infectious Diseases with HIV. AIDS & Patient Care 17(3)115-20, 2003. Society of America: Clin Infect Dis 40:1559-85, 2005. I Gardner LI, Klein RS, Szczech LA, Phelps RM, Listings are limited to the 5 most recent publications per Tashima K, Rompalo AM, Schuman P, Sadek RF, Tong faculty member.

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $1,401,940 $368,802 $1,770,742 for Infectious Disease Academic Year 2004 $1,497,778 $379,042 $1,876,820

Total Clinical Research Expenses Academic Year 2003 $7,747,716 $1,426,436 $9,174,152 for Infectious Disease Academic Year 2004 $8,419,705 $1,308,101 $9,727,806

BASIC RESEARCH Daniel Boden, Ph.D. I HIV-1 RNA Interference. NIH/CFAR Andrew Artenstein, M.D. Developmental Grant Program I Center for Bioterrorism and Emerging Infections. Patricia Cristofaro, M.D. Rhode Island Department of Health I Harnessing RNA to Prevent Cervical Cancer. Rhode I Novel Approaches to Inhibition of Anthrax Toxins. Island Foundation National Institutes of Health Ruth Connor, Ph.D. I Protocol H400-09 and H400-12, the Safety, I Genetically Engineered Lactobacillus as a Microbicide Tolerability, and Immunogenecity of ACAM200 Against HIV-1. National Institutes of Health Smallpox Vaccine in Adults With or Without Previous Smallpox Vaccination - A Randomized, Stephen Gregory, Ph.D. Double Blind, Fixed Dose, Phase 3 Comparison I A Collaborative for Vaccine Research and Between ACAM2000 and Dryvax Smallpox Vaccine. Development. Brown University Acambis, Inc 123 infectious disease

I Francisella Tularensis: Innate Resistance to Inhalation. I Serostim in the Treatment of HIV-Associated National Institute of Allergy and Infectious Diseases Adipose Redistribution Syndrome (HARS). Serono I A Genome-derived, Epitope-driven Tularemia I A Multi-clinic, Open Study to Evaluate the Ability Vaccine. EpiVax/National Institutes of Health of the Combination of Indinavir, Zidovudine, and Lamivudine to Result in Sustained Suppression of Michael Newstein, M.D., Ph.D. HIV-1 in Asymptomatic HIV-1 Seropositive Patients I Isolation of an Intracellular HIV-1 Inhibitor from a (Merck 060 ext.). Merck Research Laboratories Monkey Genomic Episomal Library. Miriam Susan Cu-Uvin, M.D. Hospital/National Institutes of Health, I E. Coli Lt as a Rectal and Vaginal Muscosal Adjuvant. Bharat Ramratnam, M.D. National Institutes of Health/Children’s Hospital I RNA Interference in Vivo to Decrease Viral Burden. I HIV Drug Resistance in the Genital Tract of Women. Lifespan/COBRE Pilot Project National Institute of Allergy and Infectious Disease I Daland Fellowship. American Philosophical Society I Antiviral Therapy and HIV in the Genital Tract of I Using RNA interference to dissect stem cell potential. Women. National Institutes of Health Roger Williams Medical Center/National Institutes I Establishing a Women’s HIV Clinic in Phnom of Health Penh, Cambodia: Clinical and Research Training I Novel Approaches to Target Latent Reservoirs of Development. World AIDS Foundation HIV-1. National Institutes of Health I Genital Tract HIV Shedding in Cambodian I CFAR - Core C: Immunovirology and Laboratory Women. Fogarty International Center Services. National Institutes of Health Staci Fischer, M.D. I Engineering Mucosal Resistance to I Intravenous BMS-284756 Follow-up Versus Cryptosporidiosis. Culpepper Foundation Intravenous Piperacillin Tazobactam. ICON/BRIS- I Impact of Mulit-Drug Resistant Proteins on HIV TOL-MYERS Treatment. Doris Duke Charitable Foundation Timothy Flanigan, M.D. I CFAR - Core E: HIV and Women. National CLINICAL RESEARCH Institute of Allergy and Infectious Disease I Adult Therapeutic Clinical Trials Program for Patricia Affleck HIV/AIDS. National Institute of Allergy and I Targeted Capacity Expansion Program for Substance Infectious Disease Treatment in HIV/AIDS Services. SAMHSA/The I Cerebrospinal Fluid Human Immunodeficiency Providence Center Virus-1 (HIV-1) and Cognitive Function in John Boyce, M.D. Individuals Receiving Potent Antiretroviral Therapy I Frequency and Clinical Significance of (ACTG 736). National Institute of Neurological Vancomycin-Resistant Subpopulations Among Disorders & Stroke/Washington University Clinical Isolates of Methicillin-Resistant S. aureus I Directly Observed HAART for Active Substance and Methicillin-Susceptible S. aureus. Eli Lilly Abusers, National Institutes of Health I Role of Gowns in Int. Trans/Pathog. Merck and I Adapting to HIV: A Family Intervention. National Company Institutes of Health/Rhode Island Hospital I HIV and Other Infectious Consequences of Charles Carpenter, M.D. Substance Abuse. National Institutes of Health I (SUN) Study of Unnatural History of HIV. Centers for Disease Control I Roche-Directly Observed Therapy Fund. Roche I I Thundermist project. Thundermist Health Center for Biodefense and Emerging Pathogens at Associates/Health Resources & Research Memorial Hospital. RI Department of Administration Health/Memorial Hospital I I Center for AIDS Research. National Institute of A Nutrition, Endocrine, Metabolic Center for Drug Allergy and Infectious Disease Abusers. Tufts University/National Institute of Health I Routine Testing for HIV in Primary Care Settings. 124 Memorial Hospital of Rhode Island/CDC brown medical school department of medicine

I Neurocognitive Consequences of HIV/AIDS in Melissa Gaitanis, M.D. South India. National Institutes of Health I A Multi-center, Double-blind, Randomized, I An Evaluation of Innovative Methods for Integrating Placebo-controlled Probe Study with an Additional Buprenorphine Opioid Abuse Treatment in HIV Open Label Control Arm to Evaluate the Safety and Primary Care Settings: Demonstration Model Site. Immunogenicity of a 3-Dose Regimen of the Health Resources & Services Administration MRKAd5 HIV-1gag Vaccine in Subjects with Chronic Hepatitis C Virus Infection. Merck & Company I One-on-One Intervention to Increase Female Enrollment in ACTG Trials. National Institutes of Joseph Harwell, M.D. Health/Social and Scientific Systems Inc. I Abuse and Psychiatric Disorders Among Youth. I AACTG International Initiative Phase I. Social & National Institutes of Health/Rhode Island Hospital Scientific Systems, Inc./NIAID I Building Interdisciplinary Research Careers in I AACTG Pune, India. Social & Scientific Systems, Women’s Health. National Institutes of Inc./NIH Health/Woman and Infants Hospital I Clinical Service at Thundermist Health Center. I A Pilot Study of Genital Tract and Blood Plasma Thundermist Health Associates/HRSA Virology and Pharmacology in HIV-1 Infected I Directly Observed Therapy (DOT) for TB and HIV Women. Rhode Island Foundation in Kenya. National Institutes of Health Leah Holmes, L.I.C.S.W. Mary Flynn, Ph.D. I Special Projects of National Significance - Outreach I Nutrition and HIV Infection. National Institutes of and Medical Care for HIV-Positive Ex-Offenders. Health/Tufts University Health Resources & Services Administration I I Principles of Nutrition Course. Brown University Case Management for HIV +Ex-Offenders. Rhode Island Department of Health I Comparison of a Mediterranean Diet with a NCEP Step II for Weight Loss and Metabolic Improvement. I HIV Prevention Counseling, Testing, Referral, and Rhode Island Foundation Outreach Services. RI Dept of Health/Travelers Aid I Comparison of a Mediterranean Diet with a NCEP Awewura Kwara, M.D. Step II Diet for Weight Loss and Metabolic I Molecular Epidemiological Study of Tuberculosis in Improvement. Canned Vegetable Council Rhode Island: DNA Fingerprinting and I Comparison of a Mediterranean Diet with a NCEP Conventional Analyses. Rhode Island Foundation Step II Diet for Weight Loss and Metabolic I Categorical Program for Outpatient Early Improvement. Carli Olive Oil Intervention Services with Respect to HIV Disease I Comparing a Plant Based Olive Oil Diet to a Ryan White Title IIIB Early Intervention Services. Conventional Diet in Women Diagnosed With Thundermist Health Associates/Health Resources & Breast Cancer After the Age Of 50 for Improvement Research Administration in Biomarkers and Weight Loss. Susan Komen Breast Cancer Foundation Michelle Lally, M.D. I HIV Vaccine Trials Network (VTN). National I Comparison of a Mediterranean Diet with a Institutes of Health/Harvard Medical School Conventional Diet for Metabolic Improvement in I Patients with Non-Insulin Dependent Diabetes HIV and Infectious Disease Testing and Treatment Mellitus (NIDDM). Carli Olive Oil Among Substance Abusers (K23). National Institutes of Health I Comparison of a Mediterranean Diet with a I Conventional Diet for Metabolic Improvement in HIV Rapid Testing Among Substance Abusers. Patients with non-Insulin Diabetes Mellitus National Institutes of Health (NIDD). Lifespan I Validation of Candidate HIV Vaccine T Cell Epitopes. National Institutes of Health/Brown University I Project Prevent: Comprehensive Testing, Treatment and Prevention of HIV, Hepatitis and STDs to Persons in Drug Detoxification Centers. Ittleson Foundation 125 infectious disease

I A Phase III Trial to Determine the Efficacy of I CFAR - Core F: Prevention Science Core. National AIDSVAX B/B Vaccine in Adults at Risk of Sexually Institute of Allergy and Infectious Disease Transmitted HIV-1 Infection in the United States. I Increasing Condom Use with Stage Matched VaxGen Intervention. National Institutes of I A Probe Study of the Safety, Tolerability, and Health/University of Rhode Island Immunogenicity of a 1-Dose Regimen of the I Phase I 14-Day Safety and Acceptability Study of MRKAd5 HIV-1 Gag Vaccine Versus the ALVAC- 10% Polystyrene Sulfonate. CONRAD HIV (vCP205) Vaccine in Healthy Adults Who I Fogarty AIDS International Training and Research Previously Received a 3-Dose Regimen of MRKAd5, Program. National Institutes of Health/Fogarty Ad5, or Placebo in Merck V520. Merck & Company International Center I MAP’s Targeted HIV Outreach Program: Project I Fogarty/Ellison Fellowship Program Supplement to Faith and Sara’s Light. MAP/Centers for Disease AITRP (7369). Fogarty International Center Control I Optimizing HIV Care in Less Developed Countries. I A Probe Study of the Safety, Tolerability, and Massachusetts General Hospital/NIAID Immunogenicity of a Three Dose Regimen of the I Ad5 Human Immunodeficiency Virus (HIV-1) Gag Johns Hopkins University “NIMH Collaborative Vaccine (Adenovirus Serotype 5 HIV-1 Gag Vector) HIV/STD Prevention Trial.” National Institute of in Healthy Adults (Merck 007-00). Merck Research Mental Health/Johns Hopkins University Laboratories I Prevention Trials Network, Protocol 050. National Institutes of Health/Fenway Community Health I A Phase I Dose-Ranging Study of the Safety, Tolerability, and Immunogenicity of the Merck Center Trivalent Adenovirus Serotype 5 HIV1 gag/pol/nef I Prevention Trials Network, Protocol 049. National Vaccine (MRKAd5 HIV-1 gag/pol/nef) in a Prime- Institutes of Health/Fenway Community Health Boost Regimen in Healthy Adults. Merck and Center Company I New England AIDS Education and Training Center. HRSA/University of Massachusetts John Lonks, M.D. I Outcomes of Patients Not Responding to Oral Antone Mederios, M.D. Macrolide or Beta-Lactam Therapy for the I A6J-MC-V010 - MRSA vs. MSSA. Lilly Research Treatment of Community-Acquired Pneumonia Due to Streptococcus Pneumonia HMR3647A/6012. Roldan Merchant, M.D. Aventis Pharmaceuticals Products, Inc. I HIV Post-exposure Prophylaxis for Adolescent and Children in Rhode Island Emergency Departments. I Prevalence of Gatifloxacin (Tequin)-resistance Elizabeth Glaser Pediatric AID Foundation among Streptococcus Pneumoniae Isolated Blood from Nine Hospitals. Bristol-Myers Squibb Leonard Mermel, D.O. I A Phase I/II Randomized, Placebo-controlled Trial to Grace Macalino, Ph.D. Assess the Safety and Efficacy of Intravenous I HIV Related Applied Research for Control and Immunoglobulin G (Omr-IgG-amTM IV) Prevention of HIV Infection. Centers for Disease Containing High Anti-West Nile Virus Antibody Control Titers in Patients with, or at High Risk for Progression Troy Martin, M.D. to West Nile Virus. University of Alabama at I Development of Whole Blood Spot Assay for HIV Birmingham/National Institutes of Health Genotype Testing in Resource Poor Settings. I Phase III Randomized Evaluation Committee Bristol-Myers Squibb, Inc. Blinded Study to Assess the Safety Central Venous Catheterization. Omnicare Clinical Research Kenneth Mayer, M.D. I Dover Silver Foley Catheter, Protocol #302.18. Tyco I HIV Prevention Trials Network. Fenway Community Health Center Healthcare Group I Trial to Reduce Antimicrobial Prophysaxis Errors I Behavioral Secondary HIV Prevention Interventions in India - International Research Collaboration. (TRAPE) Study. University of Tennessee/Centers for Disease Control 126 National Institute of Allergy and Infectious Disease brown medical school department of medicine

I 3M Innovative. 3 M Pharmaceutical I Blood Born Infections Among Imprisoned Drug I Linezolid vs. Vancomycin for the Treatment of Users. National Institutes of Health/Johns Hopkins Complicated Skin and Soft Tissue Infections I A Trial to Reduce Hepatitis C Among Injection Suspected of Being or Proven to be Due to Drug Users. National Institutes of Health/Rhode Methicillin Resistant Gram Positive Bacterial Island Hospital Pathogen. Pharmacia, Incorporated I Program to Improve Access to HIV Specialist Medical Care. Rhode Island Department of Health Maria Mileno, M.D. I I The Effect of Formulary Conversion From Hepatitis B Vaccination of Prisoners. Centers for Ceftazidime to Cefepime on the In Vitro Disease Control Sensitivities of Pseudomonas Aeruginosa, I Overdose Prevention, Recognition and Treatment Enterbacter Cloacae and Klebsiella Pneumoniae to Using Naloxone. The Tides Foundation Selected Antibodies. Kendle International Inc. I AMA Questionnaire. Robert Wood Johnson Foundation/Temple University Jennifer Mitty, M.D. I I Directly Observed Therapy (DOT) to Enhance Outreach and Methadone for Former Prisoners. Adherence to a Once-A-Day Highly Active National Institutes of Health/SAMHSA Antiretroviral Therapy (HAART) Regimen Among I Access to HIV/HCV Prevention after Syringe Law Substance Abusers. Bristol-Myers Squibb Change (Sapphire) Study. National Institute of I Directly Observed Therapy (DOT) to Enhance Drug Abuse/Brown University Adherence to a Once-a-Day Highly Active I Outpatient Early Intervention Services with Respect Antiretroviral Therapy (HAART) Regimen to HIV Disease. HRSA Including Tenofovir Among Hard to Reach I Hepatitis C Care. Schering Plough Populations. Gilead Sciences Emma Simmons, M.D. I The Development and Evaluation of a Pilot I Intervention to Provide directly Observed Therapy Project SEARCH: Acceptability and Feasibility of (DOT) for HAART to Women with Children. Routine HIV Testing in Primary Care Settings. National Institutes of Health National Institute of Allergy and Infectious Disease I Observed Therapy to Enhance Adherence to Highly Karen Tashima, M.D. Active Antiretroviral Therapy in Pregnant and I DMP 266 004,005, 006. DuPont Merck Postpartum Women. Boehringer Ingelheim I HIV Resistance in Antiretroviral-naïve Subjects. I Combining DOT and Prevention for HIV+ Persons Bristol-Myers Squibb, Inc. Leaving Prison. National Institute on Drug Abuse I Early Clinical Experience with Atazanavir: I Metabolic Changes Among HIV Seropositive Predictors of Success, Evaluation of Adverse Effects, Substance Users on Directly Observed Once-Daily and Appropriateness of Drug Dosing. Bristol-Myers Highly Active Antiretroviral Therapy (HAART). Squibb, Inc. National Institutes of Health/Tufts University I A Probe Study to Evaluate the Safety, Tolerability, David Pugatch, M.D. and Immunogenicity of the Adenovirus Serotype 5 Vector (MRKAd5) Human Immunodeficiency I HIV Rapid Testing for Young Substance Users. National Institute on Drug Abuse Virus Type 1 (HIV-1) gag Vaccine in HIV-1 Infected Patients. Merck and Company Josiah Rich, M.D. I A 96-Week, Randomized, Open-Label, Multi-center I Physician Patient IDU’s Pilot. Substance Abuse and Trial to Evaluate the Safety and Tolerability of the Mental Health Services Administration Antiretroviral Activity of Stavudine and I Substance Abuse Treatment and HIV/AIDS Lamivudine and Nelfianavir vs. Abacavir and Services. Substance Abuse and Mental Health Combivir vs. Combivir and Nelfinavir in HIV-1 Services Administration Infected Female Subjects. Glaxo Wellcome I Rational Opiate Treatment Policies for Incarcerated Populations. Open Society Institute

127 infectious disease

I A Phase III, 1:1 Randomized, Double-Blind, I Multi-center, Double-blind, Randomized, Dose Controlled, Multi-center Trial Comparing the Ranging Study to Compare the Safety and Activity Efficacy and Safety of Abacavir versus Zidovudine of L-000900612 Plus Tenovir and Lamivudine When Combined with Lamivudine and Efavirenz (3TC) Versus Efavirenz Plus Tenofovir and for Treatment of HIV-1 Infection in Antiretroviral Lamivudine (3TC) in ART-Naïve, HIV-Infected Therapy Naïve Adults. Glaxo Wellcome Patients’ Merck Protocol 004. Merck & Company I A Phase 3, Randomized, Double-blind, Multi-cen- I A Probe Study to Evaluate the Safety, Tolerability, ter Study of the Treatment of Antiretroviral-Naïve, and Immunogenicity of the Adenovirus Serotype 5 HIV-1-Infected Patients Comparing Tenofovir Vector Human Immunodeficiency Virus Type 1 gag Disoproxil Fumarate Administered in Combination Vaccine in HIV-1 Infected Patients. Merck Research with Lamivudine & Efavirenz versus Stavudine, Laboratories Lamivudine & Efavire. Gilead Science I A Probe Study to Obtain Peripheral Blood I A Phase III, 48-week, Randomized, Double-Blind, Mononuclear Cell (PBMC) Samples from HIV-1 Multi-center Study to Evaluate the Safety and Infected Individuals in Order to Evaluate HIV-1 Efficacy of Abacavir 600mg once Daily vs. Abacavir I Specific Cellular Immune Responses in Subjects on 300mg BID in Combination with Lamivudine and Highly Active Antiretroviral Therapy (Protocol Efavirenz in Antiretroviral Therapy Naïve HIV-1 Merck 005). Merck Research Laboratories Infected Patients. GlaxoSmith Kline I A Phase IV Investigation to Compare CSF and I A Randomized, Partially Blinded, Multi-center, Genital Secretion Virology and Tenofovir Levels Phase III, Three Arm Study Evaluating the Efficacy with Plasma Levels in HIV-1 Infected Patients who and Safety of Peginterferon alfa-2a (Ro 25-8310 are ART Naïve or Failing an Antiretroviral versus Combination Therapy of Interferon alfa-2a Regimen. Gilead Sciences (Ro22-8181) with Ribavirin for 48 Weeks and 24 I A Phase III, 48-week, Randomized, Double-Blind, Weeks. Hoffman/LaRoche Multi-center Study to Evaluate the Safety and I A Probe Study to Evaluate the Safety, Tolerability, Efficacy of Abacavir 600mg once Daily vs. Abacavir and Immunogenicity of the Adenovirus Serotype 5 300mg BID in Combination with Lamivudine and Vector Human Immunodeficiency Virus Type 1 gag Efavirenz in Antiretroviral Therapy Naïve HIV-1 Vaccine in HIV-1 Infected Patients. Merck Res. Labs Infected Patients. GlaxoSmithKline I A Phase III, Randomized, Multi-center, Parallel I A Phase III Randomized, Open-Label, Multi-center Group, Open-Label, Three Arm Study to Compare Study of the Safety and Efficacy of Efavirenz Versus the Efficacy and Safety of Two Dosing Regimens of Tenofovir when Administered in Combination with GW433908/Ritonavir versus Lopinavir/Ritonavir the Abacavir/Lamivdine Fixed -Dose Combination for 48 weeks in Protease Inhibitor Experienced Tablet as a Once-Daily Regimen in Antiretroviral HIV-Infected Adults. GlaxoSmith Kline Naïve HIV-. GlaxoSmithKline I A Phase IIIB, Randomized, Open-Label, Multi-center Study of the Safety and Efficacy of GW433908 Lynn Taylor, M.D. I (700mg BID) plus Ritonavir (100mg BID) versus Pilot Study to Evaluate a Multidisciplinary Lopinavir/Ritonavir (400mg/100mg BID) when Treatment and Support Program to Treat Hepatitis Administered in Combination with the C Virus (HCV) in Patients Co-infected with Abacavir/Lamivudine (600mg/300mg). Human Immunodeficiency Virus (HIV). Lifespan GlaxoSmithKline I Coninfection Support Group. Roche Laboratories

I An Open-label Phase III Study to Assess the Long Brenda Urbina, M.D. Term Safety Profile of GW433908 Containing I ACTG 2002 Minority AIDS Training Program. Regimens in HIV-1 Infected Adults. GlaxoSmith Kline National Institutes of Health/Social and Scientific Systems Inc

128 brown medical school department of medicine

NEPHROLOGY OVERVIEW

he Division of Renal Diseases experienced significant growth in clinical and academic Tprograms during the past two academic years. This was most obviously manifest by the addition of three new faculty to the division. Dr. John Wallace O’Bell joined the Division of Renal Diseases, Department of Medicine as an Assistant Professor in the Teaching Scholar Track in August 2004. With John’s arrival, there is once again a full-time academic nephrologist based at the Miriam Hospital, a situation that has not existed since Dr. Rex Mahnensmith left the Miriam more than twelve years ago. Dr. O’Bell received his A.B. in biology from Harvard College and his M.D. degree from Case Western Reserve University School of Medicine. His residency training in Internal Medicine was obtained at the Beth Israel Deaconess Medical Center followed by a nephrology fellowship at Tufts- New England Medical Center. Dr. O’Bell divides his time between clinical practice, teaching and clinical research. His academic office is located among the Department of Medicine offices on the third floor of the main hospital building. Dr. O’Bell also has a clinical outpatient practice in the Fain building at Miriam. Dr. O’Bell is working with the Division Director, Lance Lance Dworkin, M.D., Professor of Medicine; Director, Dworkin, to coordinate student, resident and fellow Division of Nephrology education in nephrology, to direct the Miriam dialysis Brown Medical School. Dr. Hsu received her B.A. in unit and, in general, to oversee all aspects of academic biology and her M.D. degree from Brown University, and clinical nephrology at The Miriam Hospital. John completing medical school in 1998. She then joined the plans to develop a clinical research program at The Brown Medical School Categorical Residency Program Miriam, and to facilitate enrollment of Miriam patients in Internal Medicine at Rhode Island Hospital, which in clinical trials ongoing in the division at Rhode Island she completed in 2001. In 2002, she joined the Hospital. We are very excited that this talented and ded- Nephrology Fellowship Program at Brown, completing icated physician has joined the Division and anticipate her training in nephrology in 2004. Dr. Hsu was an that he will make a significant contribution to academic outstanding fellow who was actively involved in clinical nephrology at The Miriam Hospital. research and teaching during her fellowship. That Associated with this change and beginning June28, experience led to co-authorship on a publication 2004, members of the full-time faculty of the Division describing the effects of vitamin supplementation on of Renal Diseases and the University Medicine hyperhomocysteinemia in dialysis patients. Foundation are now available to provide consultations As a member of the division, Dr. Hsu attends on the on in-patients with nephrologic problems at The inpatient and outpatient services at The Miriam Miriam Hospital 24 hours a day, 365 days a year. UMF Hospital and at the VA hospital, where also sees physicians providing nephrology consultative services patients in the renal clinic and directs the VA dialysis at Miriam include Drs. Dworkin, O’Bell, Susie Lee Hu unit. Since joining the division she has not only pro- and, beginning in December 2004, a recent outstanding vided outstanding medical care to our complex graduate of our own residency and fellowship training patient population and but has also interacted exten- programs, Dr. Natalie Huang Hsu. Dr. Hsu joined the sively with residents and fellows as a lecturer and on division as Clinical Assistant Professor of Medicine at the nephrology services. 129 nephrology

Also joining the division as Instructor in facility in Warwick, RI. In this technique, patients Medicine(Research), Brown Medical School is Dr. with ESRD receive a long, 7-hour course of hemodial- Rujun Gong. Dr. Gong was recruited as part of a ysis overnight while they are sleeping in the dialysis national search for a PhD scientist with expertise in facility. This is about twice the amount of dialysis that molecular/cell biology and in the pathogenesis of patients typically receive in a standard daytime shift. renal disease. Dr. Gong obtained his MD and PhD At present, there are approximately 20 patients in the degrees from Nanjing University Medical School in nocturnal program, making it the largest in New Nanjing, China. Dr. Gong came to Brown Medical England and one of the largest in the United States. School in November, 2001 to join the laboratory of Preliminary data suggests that a variety of clinical and Lance Dworkin as a post-doctoral research fellow. biochemical markers are improved with the longer, Rujun did an outstanding job in that capacity, pro- nocturnal treatment. The program is particularly well ducing novel data on the effects of hepatocyte growth suited to young people attending school or to those factor on matrix turnover and as a modulator of renal that are employed during the daytime. In fact, a sig- inflammation, both processes contributing impor- nificantly greater proportion of nocturnal patients is tantly to progression of chronic renal disease. He has rehabilitated and falls into these categories as compared been a remarkably productive investigator and the to the general dialysis population. author of 6 peer-reviewed original reports since The Division has ongoing active programs in both coming to Brown. Dr. Gong is extremely skillful in the basic and clinical research. Major expansion in the clin- laboratory. Most important, he is able to develop and ical research program occurred with the funding and apply novel techniques to answer the important initiation of the CORAL trial. Dr, Dworkin is the study questions that are generated during his studies. Dr. chair for a large consortium of investigators (approxi- Gong has outstanding potential to become an inde- mately 90 enrolling centers) that are attempting to pendent investigator and we welcome the opportunity determine the best therapy for patients with renal vas- to continue to collaborate with him as a result of his cular disease. The CORAL study is comparing the transition to a full-time faculty position. effects of renal artery angioplasty and stenting with During the past year, the Division continued to medical therapy versus optimal medical therapy alone expand its clinical activities in providing renal replace- on combined cardiovascular and renal outcomes in ment therapy to patients with acute and chronic renal 1100 patients with atherosclerotic renal vascular dis- disease. The inpatient dialysis units at the Rhode ease and hypertension. The study was funded by the Island and Miriam Hospitals remain quite busy and National Heart Lung and Blood Institute beginning perform approximately 8000 dialysis treatments per April, 2004 and has a combined budget of approxi- year, primarily to hospitalized patients with acute and mately $27 million dollars for the 6 year period during chronic renal disease. The Dialysis Unit at Rhode which the study will be conducted. Island Hospital also provides plasmapheresis to Dr. Andrew Bostom is the Principal Investigator for patients with a variety of renal, hematologic and neu- two National Institutes of Health grants supporting rologic disorders. Continuous Veno-Venous important clinical research projects. “Serum Total Hemodiafiltration (CVVHDF) is a form of continuous Homocysteine and C-Reactive Protein as Predictors of renal replacement therapy that is used primarily to Arteriosclerotic Outcomes in The Irbesartan Type 2 treat hemodynamically unstable, critically ill patients Diabetic Nephropathy Trial (IDNT)” is an observa- with acute renal failure in intensive care units. First tional study funded by the National Heart, Lung, and introduced at The Miriam Hospital 2001, CVVHDF is Blood Diseases Institute. The study will determine now commonly employed in most of the critical care baseline serum total homocysteine (tHcy) and C- units at Rhode Island & The Miriam Hospitals. reactive protein (CRP) concentrations in the IDNT to The Division has also experienced continued and evaluate the potential independent relationship significant growth in the size of its end stage renal between these putative CVD risk factors and subse- disease (ESRD) program. Division faculty now oversee quent CVD morbidity and mortality, in this patient the care of more than 100 patients with ESRD treated population. “The Folic Acid for Vascular Outcome at 6 outpatient dialysis in and around the Providence Reduction In Transplantation (FAVORIT)”,is a multi- metropolitan area. Under the leadership of Douglas center, randomized, double-blind controlled clinical Shemin, MD, a particularly successful and innovative trial sponsored by the National Institute of Diabetes nocturnal dialysis program was started at the dialysis & Digestive & Kidney Diseases. This 8-year trial is 130 brown medical school department of medicine

designed to determine whether treatment with a stan- and international meetings and has generated a sig- dard multivitamin augmented with high doses of folic nificant number of peer-reviewed publications in the acid, vitamin B6 and vitamin B12 reduces the rate of last 2 years. There is also an important educational cardiovascular disease outcomes in renal transplant component to the laboratory program, which pro- (graft) recipients relative to participants receiving a vides opportunities for students, residents, renal fel- similar multivitamin that contains no folic acid and lows, and post-doctoral research fellows to gain lower (i.e., Estimated Average Requirement) amounts experience in laboratory investigation. of vitamins B6 and B12. The FAVORIT trial will The Division of Renal Diseases performs between 100 demonstrate whether or not tHcy-lowering treatment and 200 biopsies annually of native or transplanted is effective in reducing CVD outcomes among renal kidneys. Typically, this procedure incorporates ultra- transplant recipients. Moreover, the findings will be sound localization of the kidney, and the Division applicable to the much larger overall pool of patients uses its own ultrasound machine, to perform trans- who have chronic renal insufficiency. With 4000 par- plant kidney biopsies at the bedside. This has resulted ticipants drawn from 20 major North American and in increased efficiency and convenience for our Canadian renal transplant centers, FAVORIT is the patients, and has significantly enhanced our ability to largest study of CVD prevention ever undertaken in perform this important procedure. In renal transplant the chronic renal disease. patients, subclinical chronic allograft rejection is an Other funded clinical studies currently underway important problem leading ultimately to graft loss. include protocols examining the effects of newer Subclinical rejection can be detected by performing immunosuppressive agents on the course of IgA protocol driven renal biopsies on a regular schedule nephropathy. The Division currently employs 3 full- and such a biopsy program has been implemented in time research coordinators and, on average, about a our transplant population facilitated by the availabili- dozen clinical trials are underway at any given time ty of bedside ultrasound. involving division faculty and fellows. These trials The renal fellowship at Brown University has been in have enrolled patients with diverse diseases, including existence for more than 30 years. During the past 2 acute and chronic renal failure, hypertension, diabetes years, we continued to experience increased interest in as well as dyslipidemia. The clinical research program our nephrology training program, which enrolls three includes NIH, industry and investigator initiated, fellows each year and this past year received over 150 internally funded trials that have lead to numerous applications from residents from our own program as presentations and peer-reviewed publications. well as from other first rate academic institutions. For Dr. Lance Dworkin directs the basic science research the first time this year, the application process will be program, which involves close collaboration with performed electronically using the ERAS system, Abdallah Rifai, a PhD investigator in the Department which has been utilized for several years to collect and of Pathology. Discussed above, the group now also screen applicants to the Internal Medicine Residency includes Rujun Gong, MD, PhD, who has extensive Program. We anticipate that moving to an electronic experience in molecular/cell biology and in the patho- application will further increase the number of appli- genesis of renal disease. There is an open position for cations to our already highly competitive fellowship another physician scientist and a search in underway program. Our fellows rotate through Rhode Island to identify and recruit that individual. The main Hospital, The Miriam Hospital, and the VA Hospital thrust of the laboratory program is the investigation where they contribute significantly to patient care as of the mechanisms accounting for progression of well as to resident and medical student education. chronic kidney disease. The laboratory utilizes a vari- ety of techniques, from physiologic studies in whole TRANSPLANTATION animal models of chronic kidney disease, to cell cul- The Division of Organ Transplantation remains one ture, to advanced molecular methods including gene of the busiest and aggressive kidney transplant centers profiling. One important area of investigation is on in New England. Since the inception of the program the effects of hepatocyte growth factor on matrix in 1997, close to 600 kidney transplant procedures turnover and as a modulator of renal inflammation, have been performed at Rhode Island Hospital, aver- both processes promoting chronic renal injury and aging between 70-80 transplants per year. The progression to ESRD. The laboratory has consistently Transplant Clinic follows a cadre of over 1100 trans- produced data that has been presented at national plant recipients. This accounts for over 1300 clinic 131 nephrology

visits to the transplant nephrologists at Rhode Island TRANSPLANT RESEARCH Hospital, providing ample experience for training fel- The Transplant Division continues to participate in a lows and house staff. To better accommodate the number of pharmaceutical company sponsored stud- needs of our transplant patients, the Division has ies evaluating the efficacy of various drug regimens in added a number of medical personnel. Dr. Staci preventing renal allograft rejection. These include a Fischer joined the staff in 2005 as Director of number of investigator-initiated studies focusing on Transplant Infectious Diseases. Additionally, Dr. the pharmacodynamic effects of immunosuppressive Lowell McRoberts provides vital psychiatric support therapies in select patient populations. Currently, the to our patients. Division is involved in five ongoing trials and employs Pancreas transplantation was introduced to the pro- two full-time research personnel. gram in 2003. Since that time, 16 cadaver pancreas Dr. Yango has recently introduced a program for proto- transplant procedures have been performed. This pro- col renal biopsies for all transplant recipients in our cedure is performed typically in individuals that have center for primary and secondary prevention of chronic either already received a kidney transplant, or do so in allograft nephropathy. In addition, we are also actively a combined procedure. In selected individuals with conducting pilot studies in the area of inducing specific debilitating insulin dependent diabetes mellitus, this unresponsiveness with donor specific peripheral blood procedure markedly improves quality of life. mobilized bone marrow stem cells in recipients of living donor mismatched renal allografts.

FACULTY TRANSITIONS New Faculty

Rujun Gong, Ph.D., Instructor (Research) Rhode Island Hospital Natalie H. Hsu, M.D., Clinical Assistant Professor, Rhode Island Hospital Susie Lee Hu, M.D., Assistant Professor of Medicine, Rhode Island Hospital Ali Nayer, M.D., Assistant Professor of Medicine, Rhode Island Hospital John O'Bell, M.D., Assistant Professor of Medicine, Miriam Hospital

FACULTY MEMBERS John O’Bell, M.D., Assistant Professor of Medicine, Miriam Hospital FULL-TIME FACULTY (Hospital and Foundation Based) Douglas Shemin, M.D., Associate Professor, Rhode Lance D. Dworkin, M.D., Director, Professor, Rhode Island Hospital, University Medicine Foundation Island Hospital, University Medicine Foundation Angelito Yango, Jr., M.D., Clinical Assistant Professor, J. Gary Abuelo, M.D., Associate Professor, Rhode Rhode Island Hosp., University Medicine Foundation Island Hospital, University Medicine Foundation VOLUNTEER FACULTY Andrew G. Bostom, M.D., M.S., Associate Professor, Joseph Chazan, M.D., Clinical Professor, Rhode Island Hospital, University Medicine Foundation Rhode Island Hospital Reginald Gohh, M.D., Associate Professor, Rhode Jeffrey Clement, M.D., Clinical Assistant Professor, Island Hospital, University Medicine Foundation Miriam Hospital Rujun Gong, Ph.D., Instructor (Research), Christopher Cosgrove, M.D., Clinical Instructor, Rhode Island Hospital Rhode Island Hospital Natalie H. Hsu, M.D., Clinical Assistant Professor, Richard Cottiero, M.D., Clinical Associate Professor, Rhode Island Hospital Miriam Hospital Susie Lee Hu, M.D., Assistant Professor of Medicine, Raymond Endreny, M.D., Clinical Associate Professor, Rhode Island Hospital Rhode Island Hospital Ali Nayer, M.D., Assistant Professor of Medicine, Elkin Estrada, M.D., Clinical Instructor, Rhode Island Hospital Miriam Hospital Miriam Hospital 132 brown medical school department of medicine

Boyd P. King, M.D., Clinical Associate Professor, I Medical Director, Artificial Kidney Centers of Rhode Island Hospital Rhode Island (East Providence, North Providence, Thomas Krahn, M.D., Clinical Assistant Professor, Woonsocket, Warwick Outpatient Dialysis Centers, Rhode Island Hospital Inpatient Dialysis Programs). George Lee, M.D., Clinical Instructor, I American Heart Association Scientific Sessions 2003, Rhode Island Hospital Cardiovascular Seminars. Renovascular Hypertension and Ischemic Nephropathy: A Costly, Invasive and Charles E. McCoy, M.D., Clinical Associate Professor, Sometimes Dangerous Work-Up Without Objective Rhode Island Hospital Evidence of Benefit. Orlando, FL. November 9, 2003. Ildiko Medve, M.D., Clinical Instructor, I American Society of Nephrology 36th Annual Rhode Island Hospital Meeting and Scientific Exposition. The Mark Siskind, M.D., M.S., Clinical Associate Hypertensive Diabetic with CKD: Initiating the Professor, Rhode Island Hospital Best Therapeutic Regimen at the Official Evening Michael Thursby, D.O., Clinical Instructor, Symposium. San Diego, CA. November 15, 2003. Rhode Island Hospital I American College of Physicians, Rhode Island Marc Weinberg, M.D., Clinical Associate Professor, Chapter Scientific Meeting. Diabetes Symposium – Miriam Hospital Comprehensive Care of the Diabetic Patient. David C. Yoburn, M.D., Clinical Associate Professor, Hypertension and Nephropathy in Type II Memorial Hospital of Rhode Island Diabetics: Is a Handful of ACE’s Enough to Win? Steven Zipin, M.D., Clinical Assistant Professor, Warwick, RI, May 5, 2004. Miriam Hospital Reginald Gohh, M.D. I Appointed to Medical Staff, Artificial Kidney NATIONAL AND INTERNATIONAL Center of Rhode Island, Providence, Rhode Island HONORS AND RECOGNITION Invited Presentations: OF FACULTY I Morbidity and Mortality Conference, Rhode Island Hospital, Providence, RI March 2003, “Pulmonary- J. Gary Abuelo, M.D. Renal Syndrome” Invited Presentations: I Rhode Island Diabetes and Endocrine Society, I “Resistant Hypertension and Hypertensive Providence, RI, Nov 2003, “Medical Outcomes in Emergencies”.Luis E. Aybar Hospital, 5th Pancreas Transplantation” International Congress, Santo Domingo, May 2003 Natalie H. Hsu, M.D. Andrew G. Bostom, M.D., M.S. Invited Presentations: Invited Presentations: I “Anemia in Chronic Renal Failure,” Renal Grand I “The Kidney and Homocysteine Metabolism”, Rounds, Rhode Island Hospital, Providence, RI ASN/ISN World Congress of Nephrology, San I “Renal Manifestations of Cystic Fibrosis,” Renal Francisco, CA Grand Rounds, Rhode Island Hospital, Providence, RI I “Management of Dyslipidemia in Chronic Renal I “Renal Manifestations of Sickle Cell Anemia,” Renal Disease”,Renal Grand Rounds, Rhode Island Grand Rounds, Rhode Island Hospital, Providence, RI Hospital, Providence, RI Susie L. Hu, M.D. I “Measurement and Parameters and Methodologies Invited Presentations: in Chronic Renal Disease, ASN Renal Week, I Medical Grand Rounds: ”Renal Update: Current Philadelphia, PA Approaches to Proteinuria.” Lance D. Dworkin, M.D. I Department of Medicine, Brown University, School I Fellow, American College of Physicians/American of Medicine. October 26, 2004 Society of Internal Medicine I Renal Grand Rounds: “Treatment of HCV I Member, Editorial Board, Clinical Nephrology Associated Glomerulopathies.”

133 nephrology

I Division of Renal Diseases, Department of Reginald Gohh, M.D. Medicine, Brown University, School of Medicine. I Medical Advisory Board, National Kidney February 18, 2005 Foundation – Regional Board of Directors of Massachusetts and Rhode Island John W. O’Bell, M.D. I Board of Directors and Chairman of Transplant Invited presentations: Committee, ESRD Network of New England I Renal Grand Rounds, “Anemia in Acute Renal Failure” I Poster Presentation at the American Society of Douglas Shemin, M.D. Nephrology Meeting. “Epidemiology and Outcomes I American Society of Nephrology, 2003 Annual of Acute Renal Failure in Hospitalized Patients: A Meeting Abstract Reviewer National Survey

Douglas Shemin, M.D. TEACHING ACTIVITIES I Named Chairman, End Stage Renal Disease Network of New England EDUCATION HONORS

Angelito Yango, Jr., M.D. Lance D. Dworkin, M.D. Invited Presentations: I Dean’s Teaching Excellence Award, Brown Medical I Transplant Grand Rounds, “Humoral Immune School, 2003, 2004 Response in Transplant Recipients” Reginald Gohh, M.D. I Transplant Grand Rounds, “Hepatitis C in Kidney I Dean’s Teaching Excellence Award, Brown Medical Transplantation” School, 2003, 2004 I Nurse’s Lecture Series, “Medical Aspects of Kidney Susie L. Hu, M.D. Transplantation” I Dean’s Teaching Excellence Award, Brown Medical School, 2004 RESEARCH AND OTHER SCHOLARLY ACTIVITIES John W. O’Bell, M.D. I Dean’s Teaching Excellence Award, Brown Medical School FACULTY MEMBERS OF STUDY SECTIONS AND ADVISORY COMMITTEES Douglas Shemin, M.D. I Dean’s Teaching Excellence Award, Brown Medical Lance D. Dworkin, M.D. School I National Kidney Foundation Executive Committee of the Council on Hypertension Angelito Yango, Jr., M.D. I Medical Advisory Board, National Kidney I Phi Sigma Biological Honor Society Foundation of Massachusetts, Rhode Island, New I Leo Davidoff Award for Excellence in Teaching Hampshire & Vermont I Young Investigator’s Award I Homer W. Smith Award Committee, American Heart Association, American Society of Nephrology TEACHING RESPONSIBILITIES

I American Society of Nephrology, Government J. Gary Abuelo, M.D. Relations Committee I Program Director, Nephrology Fellowship I National Institute of Health, General Medicine B I Lecturer/Small Group Preceptor, Renal Study Section & Urology Special Emphasis Panel Pathophysiology, Brown Medical School I Chairman, American Society of Nephrology Ad- hoc Public Policy Priorities Working Group on Lance D. Dworkin, M.D. Increasing R01 grants for kidney disease research I Small Group Leader, Renal Pathophysiology, Brown Medical School I Harvard Medical School, Intensive Board Review and Contemporary Issues in Nephrology I Noon Conference Lecture Series, Rhode Island and Miriam Hospitals

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I Renal ICU Rounds, Miriam Hospital, Lecturer I Outpatient attending with renal fellows for general I Physiology Conference, Lecturer nephrology I Hypertension Lecture, Ambulatory Block Rotation Ali Nayer, M.D. Medical Residency I Lecturer/Small Group Leader, Renal I Preceptor with medical students Pathophysiology, Brown Medical School I Noon Conference Lecture Series, Rhode Island Reginald Gohh, M.D. Hospital and The Miriam Hospital I Lecturer/Small Group Leader, Renal Pathophysiology (Biomed 281) I Provide lectures on renal pathophysiology to resi- dents and fellows including morning report, noon I Longitudinal Clinic Preceptor, Precept a 3rd year conferences. medical student on a weekly basis I Attending physician on the renal electives during I Provide lectures on renal pathophysiology and which all consults and admissions are discussed in transplant related issues to residents and fellows detail including morning report, noon conferences. I Clinic attending with renal fellows for general I Attending physician on both the renal and trans- nephrology clinics plant electives during which all consults and admis- sions are discussed in detail John W. O’Bell, M.D. I Organizer of monthly CME activity – Transplant I Lecturer/Small Group Leader, Renal Conference Pathophysiology, Brown Medical School I Organizer of renal pathophysiology lecture series I Noon Conference Lecture Series, Rhode Island for students/residents taking renal elective –Rotator Hospital and The Miriam Hospital Conference I Inpatient Teaching Attending, The Miriam Hospital I Organizer for Transplant Grand Rounds (monthly) Douglas Shemin, M.D. I Teaching attending for inpatient ward team I Course Co Leader, Renal Pathophysiology, Brown I Clinic attending – attend the transplant clinic in Medical School conjunction with the renal fellows I Preceptor, Internal Medicine Clerkship, Rhode Susie L. Hu, M.D. Island Hospital I Co-course Leader, Renal Pathophysiology, Brown Angelito Yango, M.D. University, School of Medicine 2005 I Lecturer/Small Group Leader, Renal I Noon Conference Lecture Series, Rhode Island, Pathophysiology (Biomed 281) Miriam Hospital and Providence VA Medical Center I Resident lecture series on renal physiology/acid I Medical Attending Teaching Rounds, Rhode Island base problems/renal transplantation Hospital I Attending physician on both renal and transplant I Morning Report Acid-Base Teaching Sessions at electives for fellows, residents and medical students Rhode Island Hospital I Teaching attending for inpatient ward team I Attending physician for Renal Consultation and I Clinic attending with renal fellows for general Dialysis Services at Rhode Island and Miriam nephrology and transplant clinics Hospitals

Natalie Hsu, M.D. I Attending physician on inpatient consult services/renal elective for fellows, residents and medical students I Medical Resident Noon Conference Lecture Series, VA Medical Center and Rhode Island Hospital I Medical Resident Lecture Series on Acid-Base Problems 135 nephrology

NEPHROLOGY FELLOWSHIP PROGRAM Departing Fellows

Sohail Khan, M.D., Private Practice, Tampa, FL Michael Capicotto, M.D., Private Practice, New York Michael Shih, M.D., Private Practice, Massachusetts Melanie Greenan, M.D., Part-time Private Practice

Current Fellows

Greg Warren, D.O., University of Med/Dent of NJ, MD, University of Connecticut, Residency Michael Ham, M.D., University of Miami School of Medicine, M.D., Brown Medical School Internal Medicine, Residency Moses Aboagye-Kumi, M.D., University Science & Technology, Kumasi, Ghana, M.D., Brown University Internal Medicine, Residency Amit Johnsingh, M.D., SUNY Brooklyn, RI Hosp/Miriam Hospital, Brown Medical School Internal Medicine, Residency Kevin Lowery, M.D., Eastern Virginia Medical School, Georgetown University Hospital Clyde Mendonca, M.B.B.S., University of Bombay, India, Caritas St. Elizabeth’s Medical Center of Boston

SELECTED PUBLICATIONS Lance D. Dworkin, M.D. I Gong R, Rifai A, Tolbert E, Centracchio J, Dworkin Andrew Bostom, M.D. LD. HGF modulates matrix metallaproteinases and I Friedman AN, Bostom AG, Laliberty P, Selhub J, plasminogen activator/plasmin proteolytic path- Shemin D. The effect of N-acetylcysteine on plasma ways in progressive renal interstitial fibrosis. J Am total homocysteine levels in hemodialysis: A ran- Soc Neph, 14:3047-3060, December, 2003 domized, controlled study. Am J Kidney Dis 2003 I Gong R, Tolbert E, Centracchio J, Yano N, Zanabli A, Feb;4(2):442-6. Esparza A, Rifai A. HGF ameliorates progression of I Jacques PF, Bostom AG, Selhub J, Rich S, Curtis interstitial fibrosis in rats with established renal injury. Ellison R, Eckfeldt JH, Gravel RA, Rozen R. Effects Kidney International, 65(2):409-419, February, 2004. of polymorphisms of methionine synthase and I Gong R, Rifai A, Tolbert EM, Centracchio JN, methionine synthase reductase on total plasma Dworkin LD. HGF ameliorates renal interstitial homocysteine in the NHLBI Family Heart Study. inflammation in nephrectomized rats by modulat- Atherosclerosis 2003 Jan;166(1)49-55. ing the tubular expression of MCP-1 and RANTES., I Wildman RP, Mackey RH, Bostom A, Thompson T, J Am Soc Neph, 15:2868-2881, October, 2004. Sutton-Tyrrell K. Measures of obesity are associated I Biswas P, Roy A, Gong R, Yango A, Tolbert E, with vascular stiffness in young and older adults. Centracchio J, Dworkin LD. HGF induces an Hypertension 2003; 42:468-473. endothelin mediated decline in GFR. Am J of I Wildman RP, Sutton-Tyrell K, Newmabn AB, Physiol, Renal Physiol; 288(1):F8-F15, January, 2005 Bostom A, Brockwell Sarah, Kuller LH. Lipoprotein I Gong R, Rifai A, Dworkin LD. Activation of PI3K- levels are associates with incident hypertension in Akt-GSK3beta pathway mediates HGF inhibition of older adults. J Am Ger Soc 2004 June 52:916-921. RANTES expression in renal tubular epithelial cells. I Friedman AN, Hunsicker LG, Selhub J, Bostom AG: Biochem Biophys Res Commun, 330(1):27-33, April, Collaborative Study Group. Related articles, Links C- 2005. reactive protein as a predictor of total arteriosclerotic Reginald Gohh, M.D. outcomes in type 2 diabetic nephropathy. Kidney Int I Morrissey PE, Reinert S, Gohh R, Yango A, Gautam 2005 Aug 68(2):773-8 A, Monaco AP. Factors contributing to acute rejection in renal transplantation: the role of noncompliance. 136 Transplant Proc, June 2005. brown medical school department of medicine

I Tran MQ, Gohh RY, Morrissey PE, Dworkin LD, Douglas Shemin, M.D. Gautam A, Monaco AP,Yango AF. Cryptosporidium I Friedman AN, Bostom AG, Laliberty P, Selhub J, infection in renal transplant patients. Clin Neph Shemin D. The effect of oral N-acetylcysteine on total 2005:63(4): 305-9. plasma homocysteine levels in chronic hemodialysis I Morrissey PE, Gohh R, Yango A, Gautam A, patients: a randomized, controlled, double blind Monaco AP. Renal transplant survival from older study. Am J Kidney Dis 2003; 41: 442-446. donors; a single center experience. Arch Surg 2004 I Shemin D, Tuohy K. Lithium intoxication, Dialysis Apr 139(4): 384-9; discussion 389. Transplantation 2003; 8:478-481. I Mendonza A, Akhlaghi F, Gohh R. Determination I Shemin D. Dialysis in Pregnant Women with Chronic of cyclosporine in saliva using liquid chromatogra- Kidney Failure, Seminars in Dialysis 2003; 16:393-397. phy-tandem mass spectometry. Ther Drug Monit I Brem AS, Lambert C, Kitsen J, Somers M, Shemin 2004 Oct 26(5): 569-75. D. Chronic dialysis and access related morbidities in I Urbina BY, Gohh R, Fischer SA. Oerskovia xanthi- children. Dialysis Transplantation 2005; 34:278-289. neolytica endocarditis in a renal transplant patient: case report and review of the literature. Transplant Angelito Yango, M.D. I Infect Dis 2003; 5: 195-8. Yango A, Morrissey P, Zanabli A, Beaulieu J, Shemin D, Dworkin L, Monaco A, Gohh R. Comparative Susie L. Hu. M.D. Study of Prophylactic Oral Gancyclovir and I Hu, S. and Jaber B. “Ribavirin Monotherapy for Valacyclovir in High Risk Kidney Transplant HCV-Associated Membranous Nephropathy”. Recipients. Nephrology Dialysis and Clinical Nephrology. 63(1): 41-45, January 2005. Transplantation 2003; 18 (4) , 809-14. Listings are limited to the 5 most recent publications per faculty member.

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $9,330 $0 $9,330 for Nephrology Academic Year 2004 $1,121 $0 $1,121

Total Clinical Research Expenses Academic Year 2003 $2,660,081 $291,816 $2,951,897 for Nephrology Academic Year 2004 $3,056,395 $502,384 $3,558,779

CLINICAL RESEARCH I A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Effects of Lipid- Andrew Bostom, M.D. Lowering Therapy with Simvastatin and Ezetimibe I Renal Transplantation, Homocysteine Lowering Compared with Placebo on the time to a first and Cognition. Tufts University/NIDDK Cardiovascular event (myocardial Infarction, Stroke, Angioplasty. University of Oxford/Merck I Serum Total Homocysteine and C-Reactive Protein. NIH/National Heart Lung & Blood Institute I Cardiovascular Outcomes in Renal Atherosclerotic Lesions. Medical College of Ohio/NIH I A Randomized Controlled Trial of Homocysteine. NIH/National Institute of Diabetes and Digestive I A Multi-Center Open Label Randomized Phase II and Kidney Diseases Study to Access Safety Duration of Treatment (up to 72 hours) and Preliminary Efficacy with the Lance Dworkin, M.D. Renal Assist Device (RAD) in Patients with Acute I A Randomized Controlled Trial of Mycophenolate Renal Failure. Nephros Therapeutics Mofetil in Patients with IgA Nephropathy. Medical City Dallas Hospital 137 nephrology

Reginald Gohh, M.D. I Study to Induce Specific Unresponsiveness with I Rapamune Outcomes Assessment Registry. Syreon Donor-Specific Peripheral Blood-Mobilized Bone Corporation Marrow Stem Cells (PBSCs) in Recipients of Living I Evaluation of Immune Globulin Intravenous, Donor Mismatched Renal Allografts Treated with Human Manufactured Using a New Thymoglobulin and Standard Cyclosporine Based Chromatographi Method (IGIV-V), 10% as an Immunosuppression. Amgen, Inc. Agent to Reduce Anti-HLA Antibodies and I An Open -Label, Prospective, Randomized, Improve Transplantation Result in Cross match Controlled, Multi-Center Study Assessing Fixed Positive Living Donor Kidney Allograft Recipients. Dose vs. Concentration Controlled Cellcept Cedars-Sinai Medical Center/NIH Regimens for Patients Following a Single Organ I An Open-Label, Concentration-Controlled, Renal Transplantation in Combination with Full Randomized, 12 month Study of Dose and Reduced Dose. Roche Laboratories Prograf+Rapamune+Corticosteroids Compared to Douglas Shemin, M.D. Cyclosporine Capsules, USP (Modified) + I A Randomized Open Label Study to Assess the Rapamune+ Corticosteroids in High Risk Renal Safety of Epoetin Alfa Manufactured by Deep Tank Allograft Recipients. Wyeth Pharmaceuticals, Inc. Technology and Epoetin Alfa Manufactured by I A One Year, Multi-center, Double Blinded, Double Roller Bottle Technology in Subjects with Chronic Dummy, Randomized Study to Evaluate the Safety Kidney Disease not on Dialysis. Amgen and Efficacy of Two Doses of FTY720 Combined I Nabi 1371: A Phase 3, Multi-center, Randomized, with Full Dose Neoral and Steroids, in De Novo Placebo Controlled, Double Blind Study to Evaluate Adult Renal Transplant Recipients. Novartis Efficacy of Staph Vax, a Bivalent Staphylococcus Pharmaceuticals Corporation Aureus Glycoconjugate Vaccine in Adults on I ORION Study - A Randomized Open-Label Study Hemodialysis. Nabi Biopharmaceuticals to Compare the Safety and Efficacy of Two- I Correction of Hemoglobin & Outcomes in Renal Different Sirolimus Regimens with a Tacrolimus Insufficiency (CHOIR). Ortho Biotech Clinical +Mycophenolate Mofetil Regiment in the Novo Affairs, LLC/Orthobiotech Allograft Recipients. Wyeth Pharmaceuticals, Inc. I DIRECT Study: Diabetes Incidence After Renal Transplantation: Neoral C-2 Monitoring vs Tacrolimus a Six Month Open Label, Multi-center, Randomized Study to Compare the Incidence of New Onset Diabetes Mellitus and Glucose Metabolism in Patients. Novartis Pharmaceuticals Corporation

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OBSTETRIC AND CONSULTATIVE MEDICINE OVERVIEW

o provide expert care to women with medical problems in pregnancy from obstetric internists, Tgastroenterologists, and women’s behavioral health specialists; To provide internal medicine, primary care, and behavioral health services to the obstetric and gyneco- logic patients at Women & Infants Hospital and the community; To facilitate the primary care function of Ob/Gyn’s; To improve access and quality of care provided to all women; To educate medical students, internal medicine and OB/GYN residents, and Obstetric & Consultative Medicine and Gastroenterology fellows to treat medical problems in pregnancy and provide general medical and preoperative consultation; To engage in research and curriculum development in the medical and psychiatric care of pregnant and Karen Rosene-Montella, MD, Professor of Medicine and postpartum women. OB/GYN, Brown Medical School; Chief of Medicine, Women & Infants Hospital The unique expertise of the Women and Infants graduate, returned to New Zealand where she estab- Hospital Division of Obstetric and Consultative lished a new program in Obstetric and Consultative Medicine has continued to build its national and Medicine at a large teaching hospital in Auckland that international reputation as a leader in the care of will help to ensure the best possible outcomes for medical problems in pregnancy. Karen Rosene- women with medical problems in pregnancy and fur- Montella was appointed the North American ther establish Women and Infants Hospital as a world Representative to the executive of the International leader in the care of women. Niharika Mehta, MD, Society of Obstetric Medicine (ISOM) and has devel- our fourteenth fellow graduate in 2005 is joining the oped a new web-based forum for improving the care Division of Obstetric & Consultative Medicine as an of medical illness in pregnancy for the ISOM. Our attending physician in September, 2005. faculty has been invited speakers at the national meet- ings of the Society of Maternal Fetal Medicine, Karen Rosene-Montella, MD, Chief of Medicine, is Society of Obstetric Anesthesiology and Perinatology pleased to announce the addition of Ghada Bourjeily, and the American College of Physicians, the MD to the Division as our newest Obstetric Medicine International Society of Obstetric Medicine in Perth faculty member. Dr. Bourjeily joined the Division in Australia, as well as New England Journal of Medicine March, 2005 as an obstetric internist, pulmonologist sponsored courses in China and India in the past year. and critical care specialist. Research from the fellowship has won the young We are also pleased to announce that: investigators prize at the International meeting of the I Karen Rosene Montella, MD, Editor, Journal of American College of Chest Physicians and the North Obstetrics and Gynaecology. American Society of Obstetric Medicine. I Margaret Miller, MD, Assistant Professor of Each year our fellowship graduates leave the program Medicine, Brown Medical School, 2003. and go on to establish new programs in obstetric I Lucia Larson, MD, secretary-treasurer for the North medicine at universities in North America and American Society of Obstetric Medicine (NASOM), around the world. 2004 was not any different. February 2005 and was appointed as Fellowship Catherine Blackburn, MD, our thirteenth fellow Director in June 2005. 139 obstetric and consultative medicine

I Raymond Powrie, MD, president of the North Behavioral Sciences and Medical Education, The American Society of Obstetric Medicine, February Society of General Internal Medicine, The North 2005. American Society for the Study of Hypertension in I Silvia Degli-Esposti, MD Associate Professor of Pregnancy, and the Society of Obstetric Medicine (Clinical), May 2005. Anesthesiologists and Perinatologists (SOAP). Silvia Degli Esposti, MD, Director of Women’s Abstract topics included: “The Prevalence of Deep Vein Digestive Disorders announces that an Inter-institution- Thrombosis in Women Undergoing Cesarean Delivery”, al Agreement has been executed for a shared Brown “Improving Hospital Management of Pregnancy Fellowship with Rhode Island Hospital for gastroen- Induced Hypertension Using Failure Mode and Effects terology, enriching the experience of the fellows in areas Analysis”,“Are We Competent in Primary Care? An that are seldom covered during mandatory rotations, in OSCE Assessment of Residents in Obstetrics and particular, in the areas of gastrointestinal problems in Gynecology in Managing Primary Care Problems”,“An pregnancy and gastrointestinal complications of gyne- Interesting Case of Hyperthyroidism in Pregnancy”, cological disease. The GI Fellows will work one-on-one “Urinary Protein to Creatinine Ratio is a Clinically with an attending physician, attend conferences, tumor Useful Test in Pregnancy” and “How Common is Deep board, see inpatient consultations, participate in Vein Thrombosis After Cesarean Delivery?” outpatient sessions, participate in endoscopy sessions The attending physicians were also invited to give pre- and research topics of interest. sentations at national and international conferences.

Karen Rosene-Montella, MD FACULTY MEMBERS National Presentations: I Director, Workshops in Medical Complications of FULL-TIME FACULTY Pregnancy, American College of Physicians, San Karen Rosene Montella, MD, Professor of Medicine Diego, CA April 2003. and Obstetrics & Gynecology I Course Director, “Medical Problems in Pregnancy,” Raymond Powrie, MD, Associate Professor of American College of Physicians annual session, San Medicine and Obstetrics & Gynecology Francisco, CA, April 14 – 16, 2005. Lucia Larson, MD, Associate Professor of Medicine I Presenter, the American College of Obstetricians & and Obstetrics & Gynecology Gynecologists and American College of Physicians, Margaret Miller, MD, Assistant Professor of Medicine “Cardiac Disease in Pregnancy” Saratoga Springs, NY, August 19, 2004. Ghada Bourjeily, MD, Assistant Professor of Medicine I Invited speaker, the American Society of CLINICAL FACULTY Echocardiography’s Annual Scientific Session, Silvia Degli Esposti, MD, Associate Professor of “Anticoagulation in Pregnancy” Boston, MA, June Medicine (Clinical) 18, 2005 Christy Dibble, DO, Clinical Assistant Professor I Chief Editor: the American College of Physicians, Rossana Moura, MD, Clinical Instructor 2nd edition of “Medical Care of the Pregnant Patient.” February 2005. NATIONAL AND INTERNATIONAL International: HONORS AND RECOGNITION I Chaired workshop, the North American Society for Hypertension in Pregnancy, “Pre-eclampsia,” OF FACULTY Vancouver, BC, July 23 – 26, 2004. From July 2003 to June 2005, the attending physicians I Chaired workshop, the International Society of in the Division of Obstetric & Consultative Medicine Obstetric Medicine Programme, “Screening and presented numerous abstracts nationally and Management of Adverse Pregnancy Outcome and internationally. Inherited Thombophilia,”Vienna, November 14 – 15, 2004. Societies include: The American College of Chest Physician, the International Society of Obstetric Medicine (Perth, Australia), The Association for the 140 brown medical school department of medicine

Raymond Powrie, MD I Presenter: the United Arab Emirates, “Caring for National Presentations: Medical Conditions in Pregnant Women: Ten I “Medical Care of the Pregnant Women for the Things Every Clinician Should Know,”“Outpatient Primary Care Provider,” the Primary Care Conference Management of Depression,” and “Be PIH Hip!: at Beth Israel Deaconess Medical Center, October 3, Standardizing the Diagnosis and Treatment of 2003 and September 13, 2004, Boston, MA Pregnancy-Induced Hypertension to Improve I “Medical Illness in Pregnancy for the Primary Care Patient Safety,” the Practi-Med Dubai Program, Provider,” the Primary Care International Medicine: Harvard Medical International, Dubai, United Arab Principles & Practice Course in Cambridge, MA, Emirates, December 8, 2003, October 20, 2003. I Presenter, Corniche Hospital, “Acute Lung Injury in I Invited Presenter as Visiting Professor, “Medical Care Pregnancy,”Abu Dhabi, United Arab Emirates. of the Critically Ill Obstetric Patient”,Anesthesia December 2003 Grand Rounds, Brigham and Women’s Hospital, I Presenter, the Practi-Med Chennai, for Harvard March 31, 2004, Boston, MA. Medical International and Sri Ramachandra I Invited speaker, the Annual Meeting of the Society Medical College & Research Institute, “Depression of Maternal Fetal Medicine, Reno, Nevada, in Primary Care,”“Hypertension in Pregnancy” and February 7 – 12, 2005. “Ten Things Every Clinician Should Know about Medical Disorders in Pregnancy” March 13 - 14, I Invited speaker: the Medical Problems in Pregnancy 2004, Chennai, India. workshop, “hypertension, respiratory critical care and asthma,” February 2005, I Presenter, the Practi-Med Shanghai, for Harvard Medical International and Huan Shan Hospital in I Received FCCS certification (fundamentals in collaboration with The New England Journal of critical care support), Critical Care Conference, Medicine and the China Medical Tribune, Baystate Medical Center, March 17 – 18, 2005. “Managing Depression: What Every Clinician I Lecturer, “Pulmonary Edema in Pregnancy,” Should Know,”“Ensuring Healthy Pregnancies: Ten Obstetrics and Gynecology Grand Rounds. Things Every Clinician Should Know,” and I Presenter, “Thromboembolic Disease in Pregnancy,” “Innovative Programs in Patients Safety,” May 7, Obstetrics and Gynecology Residency Academic, 2004, Shanghai, China. Brigham and Women’s Hospital, Boston, MA, I Presenter, China Medical Tribune, Harvard Medical March 23, 2005. International, New England Journal and AIDS I Presenter “Hypertension in Pregnancy,” the Clinical care, “Western Approaches to MTCT American College of Physicians Annual Session, Prevention,” a program about HIV/AIDS Education San Francisco, CA, April 14 – 16, 2005. in China, Xian, China May 15, 2004, I Invited speaker, the National meeting of the North I Presenter, the North American Society for the American Society of Hospital Medicine “Inpatient Study of Hypertension in Pregnancy, “Causes of Medical Emergencies in Obstetric Patients” Pulmonary Edema in the Pregnant Patient” Chicago, IL, April 29, 2005. University of British Columbia. Vancouver, B.C., I Invited speaker, the International Meeting of the Society July 25, 2004. of Obsetric Aneasthesiologists and Perinatologists Local Presentations: (SOAP), “Strategies to Prevent Maternal Medical I Presenter, Women & Infants Hospital Grand Mortality,”Palm Springs, California. Rounds: “Making it Easier to do the Right Thing I Judge, the International Meeting of the Society of and Harder to do the Wrong Thing at Women & Obsetric Aneasthesiologists and Perinatologists Infants Hospital” and “Are you PIH HIP? (SOAP), Zuspan award for best scientific abstract Improving the Care of Hypertension in Pregnancy by collaboration of anaesthesiologists and at Women & Infants Hospital.” obstetricians, May 6, 2005. I Presenter, Women & Infants Hospital Core International: Curriculum Lecture Series, “Asthma in Pregnancy” I Presentation, the International Society of Obstetric and “Chronic Hypertension in Pregnancy.” Medicine (ISOM), “Acute Lung Injury in Pregnancy” and “Prepregnancy Counseling,” 141 October 21, 2003, Fremantle, Western Australia. obstetric and consultative medicine

Margaret Miller, MD Lucia Larson, MD II n September, 2004, Dr. Miller was invited to be on National Presentations: the “Go Red for Women” committee of the I “Renal Disease in Pregnancy” the Maternal-Fetal American Heart Association. She will be working Medicine Division at Women & Infants Hospital, with this committee to design educational pro- March 26, 2004. grams about cardiac disease in women for Ob/Gyn I Received FCCS certification, Critical Care physicians and nurse practitioners. Conference, Baystate Medical Center, March 17-18, National presentations: 2005. I “Medical Illness in Pregnancy for the Primary Care International: Provider” at Harvard Medical School, Primary Care I Chaired Workshop, the International Society of International Medicine: Principles & Practice, in Obstetric Medicine Programme, “Screening and Cambridge, MA, October 20, 2003. Management of Adverse Pregnancy Outcome and I “Cardiac Disease in Pregnancy” presented at High Inherited Thombophilia,”Vienna, November 14 – Risk Obstetric Workshop for the Society of Obstetric 15, 2004. Anesthesia and Perinatology, May 11, 2004. Silvia Degli-Esposti, MD I “Medical Illness in Pregnancy for the Primary Care Provider.” Harvard Medical School. Primary Care Invited Presentations: I Internal Medicine: Principles & Practice. October Symposium to OB/Gyn, Women & Infants 21, 2004. Cambridge, MA. Hospital, “Cholestasis in Pregnancy”,April 30, 2003. I Gastroenterology Task Force, Department of I “Heart Disease in Pregnancy: Diagnosis and Management”,presented at ACOG/NYACP Clinical Health, Hepatitis C, Village at Waterman Lake, Update: Cardiac Risk Prevention and Management Johnston, RI, May 21, 2003. in Women in New York City, May 22, 2004. I Project Link, Women & Infants Hospital, Hepatitis C, September 15, 2003. I Received FCCS certification, Critical Care Conference, Baystate Medical Center, March 17-18, 2005,. I Hepatitis Foundation International, Sex Transmission - Protecting Yourself and Your Baby. I Presenter, Grand Rounds at Norwalk Hospital “Caring for Medical Illness in Pregnancy,” Norwalk, Hilton Hotel, Mystic, CT, November 11, 2003. CT, March 24, 2005. Christy Dibble, DO I Instructor, “Masters Board Review,” Course includ- I Presenter, the Women’s Health Faculty Development ed 13 lectures covering office primary care, for Series, Brown University National Center of Ob/Gyn as well as topics on medical problems in Excellence in Women’s Health, “Colorectal Cancer pregnancy. Ob/Gyns, Baltimore, May 18, 2005. Screening” Brown University, May 2004. Local presentations: Rossana Moura, MD I Presenter, Women & Infant’s Hospital Resident I Lecturer, Brown/Women & Infants National Center Core Curriculum. “Palpitations in Pregnancy,” of Excellence Women’s Health Lecture series, “GI Providence, RI, March, 2003. Disorders: Irritable Bowel, Peptic Ulcer Disease & I Presenter, Grand Rounds, Rhode Island Hospital, GERD,” April 27, 2005. “A Case of Dyspnea in Pregnancy. Morbidity and Mortality,” Providence, RI, November, 2003. I Presenter, Current Concepts in Fetal and Neonatal Care Conference, “Chronic Hypertension in Pregnancy” Providence, RI, May 6, 2004. I Presenter, Women & Infants Hospital Grand Rounds, “Perioperative Beta-blockers,” Providence, RI April 1, 2004. I “Thrombocytopenia in Pregnancy.” Women & Infants Hospital. Resident Core Curriculum. November, 2004. Providence, RI.

142 brown medical school department of medicine

RESEARCH AND OTHER Lucia Larson, MD SCHOLARLY ACTIVITIES I BioMed 282

The Division’s interest in research is related to pregnan- Silvia Degli Espostin, MD I cy women and medical complications of pregnancy. Pathophysiology, BioMed 282 Dr. Rosene’s interests lie in thrombosis in pregnancy, EDUCATION HONORS specifically the prevention of pulmonary embolism and deep venous thrombosis in pregnancy, A-gradient Raymond Powrie, MD I in pulmonary embolism in the pregnant patient, the Dean’s Teaching Excellence Award for outstanding effect of heparin on bone density in pregnancy, teacher, Bio 282, HRGD Pathophysiology, Brown platelet activation in normal and hypertensive preg- Medical School, 2004 nancy, and curriculum development in medical con- I Top Full-Faculty Teacher of the Year Award presented sultation in pregnancy. by Chief Residents, Department of Obstetric Gynecology, Women & Infants Hospital of RI, 2004. Dr. Powrie’s research interests include pulmonary embolism, medical consultation in pregnancy, and I Special Recognition Teaching Award for exemplary curriculum development in medical consultation and teaching and commitment to Resident Medical obstetric medicine. Education. Department of Obstetrics and Gynecology, Women & Infants Hospital of RI, 2004. Dr. Larson’s research interests include thrombophilias I and recurrent spontaneous abortions, education on Top Full-Faculty Teacher of the Year presented by medical problems in pregnancy, palpitations in pregnan- Resident Medical Education. Department of cy, and preeclampsia and tolerance to paternal antigens. Obstetrics and Gynecology, Women & Infants Hospital of RI, 2003-2004. Dr. Bourjeily’s research interests include pulmonary I Dean’s Teaching Excellence Award for exemplary complications in pregnancy, and asthma and pregnancy. teaching during the 2003-2004 academic year, FACULTY MEMBERS OF STUDY SECTIONS AND Brown Medical School, 2004. ADVISORY COMMITTEES Lucia Larson, MD Karen Rosene Montella, MD I Dean’s Teaching Excellence Award for exemplary I Editor, Journal of Obstetrics and Gynaecology teaching in Bio 282-Human Growth & Reproduction, Brown Medical School, 2003. I Brown University Teaching Scholar Task Force I The Master of Arts ad eundem degree awarded by I State of RI Department of Health Advisory Brown University, Board of Fellows, 2004 Committee of the Office of Women’s Health I Appreciation Award. Women & Infant’s Women’s Raymond Powrie, MD Primary Care Center Nurse Practitioners, 2004 I Instructor, Department of Medicine, Harvard Medical School Margaret Miller, MD I Harvard Medical School, Teaching award. Medical Lucia Larson, MD Illness in Pregnancy for the Primary Care Provider. I Advisor, Brown University/Women & Infants Presented at Primary Care Internal Medicine: Hospital – National Centers of Excellence in Principles and Practice Course. October 2003 Women’s Health, Clinical Care Working Group. Silvia Degli-Esposti, MD Silvia Degli Esposti, MD I Dean’s Teaching Excellence Award – Bio 282 I Gastroenterology Task Force, RI Department of Pathophysiology/Gastroenterology, 2003 & 2004. Health Christy Dibble, DO I Top Doc of the Month, Rhode Island Monthly TEACHING ACTIVITIES Magazine 2004

Raymond Powrie, MD I BioMed 282 I Affinity Group 143 obstetric and consultative medicine

CLINICAL ACTIVITIES Our clinicians see patients for diagnoses such as thrombosis in pregnancy, cardiac disease in pregnan- During the time of July 2003 – June 2005, the cy, headaches, palpitations, hypertension and asthma. Division of Obstetric & Consultative Medicine pro- We often follow patients with chronic medical evalua- vided 2100 inpatient consultation encounters at tions for patients anticipating surgery. We also offer Women & Infants Hospital. The Division’s outpatient pulmonary function testing and preconception coun- practice in Internal Medicine and Obstetric Medicine seling for women with medical problems who are Consultation provided care to 6486 patients, most of considering pregnancy. which were consultations for the Ob/Gyn physicians.

OBSTETRIC AND CONSULTATIVE MEDICINE FELLOWSHIP PROGRAM Current Fellow Fellow Medical School Residency Program Career Plans Winnie Sia, MD University of Alberta Internal Medicine, Graduated June 2003, Return School of Medicine University of Alberta to University of Alberta Catherine Blackburn, MD University of Auckland Royal Australasian Graduated June 2004, Returned School of Medicine College of Physicians. to Auckland to start a program in Obstetric & Consultative Medicine Nadine Sauve, MD University of Sherbrooke Internal Medicine, Returned to University of University of Sherbrooke Sherbrooke, Faculty of Medicine Niharika Mehta, MD Grant Medical College, Columbia University College Graduated June, 2005. India of Physicians and Surgeons Joining Women & Infants’ Hospital, Department of Medicine as Obstetric Medicine attending, September, 2005. Elvis Pagan, MD University of North Internal Medicine Carolina Chapel Hill Rhode Island Hospital / Miriam Hospital Brown Medical School

SELECTED PUBLICATIONS

Rosene-Montella K I Pregnancy-related thrombosis and thrombophilia update: a case for prevention. Journal of Obstetrics and Gynaecology, 2003; 5:550-554

Larson L, Rosene-Montella, K I Thromboembolic Disease in Women. Subtle signs and treatment alterations. In: Women’s Health in Primary Care. May-June 2003;(6)1:142-151. Listings are limited to the 5 most recent publications per faculty member.

144 brown medical school department of medicine

PULMONARY, CRITICAL CARE & SLEEP MEDICINE OVERVIEW

he high national and international prominence of the Division of Pulmonary, Critical Care & TSleep Medicine has continued since our last report. Dr. Sharon Rounds has served as President of the American Thoracic Society 2004–2005. The American Thoracic Society is the premier respiratory society for pulmonary and critical care research. At its annual meeting over 14,000 physicians and scientists from around the world meet to present their research findings and gain knowledge of the latest advances in the field of pulmonary and critical care medicine. Leadership of this society is one of the most coveted accomplishments in our discipline and having achieved this recognition, Dr. Rounds has brought distinction to our division and to the Department of Medicine. During the last several years Dr. Rounds has been an invited speaker and visiting professor at over 20 institu- tions and conferences around the world. This has included visiting professorships at Chiba University, Chiba, Japan, Northwestern University, Keio University, Sidney Braman, M.D., Professor of Medicine; Director, Tokyo, Japan, and University of Nebraska Medical Division of Pulmonary, Critical Care and Sleep Medicine Center. She has been an invited speaker at the I Homing of bone marrow-derived stem cells and American Thoracic Society, Japanese Respiratory conversion to cells of the lung after an acute injury Society, Brazilian Thoracic Society, Asian Pacific I Early goal directed therapy in the ICU Society for Respirology, Turkish Thoracic Society, and I Natriuretic peptides blunt thrombin-induced Spanish Respiratory Society, among others. increases in pulmonary endothelial permeability Each year the investigative work of our fellows and The scope of this work attests to the broad range of faculty is presented at the American Thoracic Society interests and research expertise of our faculty. They International Conference. In the last two years, for have gained international recognition for their work example, our fellows presented the following topics of and leadership in the field of pulmonary and critical research at this meeting: care medicine with invited presentations of clinical I Bone marrow mobilization with G-CSF increases and research topics around the world. The areas of stem cell conversion to lung cells after radiation expertise of our Division continues to grow with the injury to mice addition of new faculty members. There is consider- I Bone marrow infusion and irradiation blunts able prominence in clinical research and consultative monocrotaline induced pulmonary hypertension in care in critical care medicine, end of life care, sleep mice medicine, pulmonary hypertension, respiratory mus- cle disease, airway diseases, pulmonary rehabilitation I Echocardiographic evidence of pulmonary hyper- and medical informatics in the ICU. The study of tension is associated with increased mortality in microvascular endothelial barrier function at the patients hospitalized for COPD exacerbation Veterans Administration Medical Center has been I Barriers and solutions to an open visitation policy highly productive and recognized for creativity and in the MICU excellence. NIH/NHLBI and VA Merit Review funding I Palliative care intervention in the MICU: a feasibility has been given to this group of investigators including study Dr. Elizabeth Harrington, Associate Professor of I Circulating endothelial cells and their progenitors Medicine (Research), (Endothelial Barrier Function in obstructive sleep apnea Modulation by PKC) (Signaling in Hypoxic 145 pulmonary, critical care & sleep medicine

Pulmonary vs. Systemic Endothelium), Dr. Qing Lu, Hospital has recently expanded its sleep program with Assistant Professsor of Medicine (Research), (Focal the addition of a new faculty member, Kenneth Casey, adhesion complexes and lung endothelial apoptosis) M.D., M.P.H., Clinical Associate Professor of (RhoA GTPase methylation and vascular permeabili- Medicine. Dr. Casey was formerly at The University of ty), and Dr. Sharon Rounds, Professor of Medicine, Utah School of Medicine. The Veterans (RhoA GTPase Methylation and Endothelial Cell Administration Medical Center also has an active Function), (Focal Adhesion Complexes and Lung sleep laboratory headed by Dr. Brian Kimble, Clinical Endothelial Apoptosis). Assistant Professor of Medicine. Our Division members have gained prominence and A new discipline has emerged in pulmonary medicine visibility in the academic pulmonary and critical care called interventional pulmonology. After receiving community. We are pleased to announce that Dr. F. advanced training both in the U.S. and abroad, Dr. Dennis McCool, Professor of Medicine, was chosen Muhanned Abu-Hijleh, Clinical Assistant Professor of Editor-in-Chief of the journal LUNG. Also, Dr. Mitchell Medicine, has assumed the Directorship of the Levy, Professor of Medicine, has become Senior Editor program to advance this new field. A pulmonary of the Journal of Critical Care. Dr. Levy was voted in as interventionalist is capable of performing new and council member of the governing body of the Society of specialized procedures in chest medicine including Critical Care Medicine. He has also been appointed to medical thoracoscopy, endobronchial and trans- an NHLBI working group on Respiratory Failure from bronchial biopsy and needle aspiration, endo- SARS and was interviewed on CNN Headline News bronchial ultrasound, therapeutic balloon dilatation, about the international Surviving Sepsis Initiative. Dr. argon plasma coagulation, photodynamic therapy, Linda Nici, Clinical Associate Professor of Medicine, has brachytherapy, stent placement, and foreign body been appointed to the Board of Directors of the removal. The availability of these advanced pulmonary American Association of Cardiovascular and procedures will be extremely important for the devel- Pulmonary Rehabilitation. Dr. Richard Millman, opment of a new Brown Cancer Center and also for Professor of Medicine, has been co-chair of the NHLBI the fellowship training program in Pulmonary and working group on sleepiness in adolescents and young Critical Care Medicine. adults. Drs. Kevin Dushay and Eleanor Summerhill, Assistant Professors of Medicine, have both been elected FACULTY MEMBERS to be American College of Chest Physicians Critical Care Network Steering Committee and Dr. James Klinger, Associate Professor of Medicine, has been elect- FULL-TIME FACULTY (Hospital or Foundation Based) ed to the Program Committee of the Assembly on Muhanned Abu-Hijleh, M.D., Clinical Assistant Pulmonary Circulation of the American Thoracic Professor, Rhode Island Hospital, University Society. Finally, Dr. Sidney Braman, Division Director Medicine Foundation and Professor of Medicine, has been appointed by the Alice Bonitati, M.D., Clinical Associate Professor, United Nations to an advisory committee to the United Rhode Island Hospital, University Medicine Foundation Nations Environment Program as a member of the Sidney Braman, M.D., Director, Professor, Rhode Medical Applications Technical Options Committee. Island Hospital, University Medicine Foundation The sleep medicine program of the Division has *E. Jane Carter, M.D., Assistant Professor, expanded considerably. The Lifespan laboratories are Miriam Hospital, University Medicine Foundation located in East Providence, The Miriam Hospital, and Kenneth Casey, M.D., M.P.H., Clinical Associate Newport Hospital under the direction of Dr. Richard Professor, Memorial Hospital Millman, Professor of Medicine. These laboratories provide outstanding clinical care and have become a Vera De Palo, M.D., Associate Professor, leading research center for the study of patients with Memorial Hospital sleep disordered breathing. There are currently three Kevin Dushay, M.D., Assistant Professor, Rhode Island R01 supported projects ongoing in the sleep laborato- Hospital, University Medicine Foundation ry. The projects are: “Motivating Adherence to CPAP Allan Erickson, M.D., Associate Professor, and Obstructive Sleep Apnea”,“Trazodone for Sleep VA Medical Center Disturbance—Early Alcohol Recovery”,and “Sleep Elizabeth Harrington, Ph.D., Assistant Professor, Apnea in Look AHEAD Participants”.The Memorial 146 VA Medical Center brown medical school department of medicine

Brian Kimble, M.D., Clinical Assistant Professor, Walter Donat, M.D., Clinical Associate Professor, VA Medical Center Rhode Island Hospital James Klinger, M.D., Associate Professor, Rhode Island David Ettensohn, M.D., Clinical Associate Professor, Hospital, University Medicine Foundation Memorial Hospital Mitchell Levy, M.D., Professor, Rhode Island Hospital, Ronald Gilman, M.D., Clinical Assistant Professor, University Medicine Foundation Miriam Hospital Qing Lu, Ph.D., Assistant Professor, VA Medical Center Peter Karczmar, M.D., Clinical Assistant Professor, F. Dennis McCool, M.D., Professor, Memorial Hospital Miriam Hospital Richard Millman, M.D., Professor, Rhode Island Naomi Kramer, M.D., Clinical Assistant Professor, Hospital, University Medicine Foundation Rhode Island Hospital Linda Nici, M.D., Clinical Associate Professor, John Ladetto, M.D., Clinical Instructor, VA Medical Center Memorial Hospital Annie Lin Parker, M.D., Associate Professor, Daniel Lederer, M.D., Clinical Assistant Professor, Memorial Hospital Miriam Hospital Sharon Rounds, M.D., Professor of Medicine and Timothy Liesching, M.D., Clinical Assistant Professor, Pathology and Laboratory Medicine, VA Medical Memorial Hospital Center James Myers, M.D., Clinical Associate Professor, Patricia Russo-Magno, M.D., Clinical Assistant Miriam Hospital Professor, Memorial Hospital Charles Sherman, M.D., MPH, Clinical Associate Michael Stanchina, M.D., Assistant Professor, Rhode Professor, Miriam Hospital Island Hospital, University Medicine Foundation Joseph Tarpey, M.D., Clinical Assistant Professor, Tihomir Stefanec, M.D., Clinical Assistant Professor, Miriam Hospital Memorial Hospital Joel Weltman, M.D., Ph.D., Clinical Professor, Eleanor Summerhill, M.D., Assistant Professor, Rhode Island Hospital Memorial Hospital John Zwetchkenbaum, M.D., Clinical Instructor, Nicholas Ward, M.D., Assistant Professor, Rhode Memorial Hospital Island Hospital, University Medicine Foundation ADJUNCT FACULTY *Joint Appointment in Infectious Disease Nicholas Hill, M.D., Adjunct Professor, VOLUNTARY FACULTY Tufts New England Medical Center William Corrao, M.D., Clinical Professor, Joseph Meharg, M.D., Adjunct Assistant Professor, Rhode Island Hospital Roger Williams Medical Center R. William Corwin, M.D., Clinical Assistant Professor, Michael Passero, M.D., Adjunct Associate Professor, Rhode Island Hospital Roger Williams Medical Center

FACULTY TRANSITIONS

Departing Faculty

Bernard Cieniawa, D.O., Clinical Instructor, FAHO Curtis Mello, M.D., Clinical Assistant Professor, Rhode Island Hospital Padmaja Muthiah, M.D., Memorial Hospital Scott Skibo, M.D., Memorial Hospital Robert Westlake, M.D., Assistant Professor, Memorial Hospital New Faculty

Kenneth Casey, M.D., M.P.H., University of Utah School of Medicine, Clinical Associate Professor Patricia Russo-Magno, M.D., Clinical Assistant Professor, Memorial Hospital 147 pulmonary, critical care & sleep medicine

NATIONAL AND INTERNATIONAL I American College of Chest Physicians Annual HONORS AND RECOGNITION Meeting Meet-the-Professor Seminar “COPD”, OF FACULTY Moderator and Lecturer “Dyspnea in the Elderly Patient” and “Role of PDE4 inhibitors asthma and COPD”,Orlando, FL, October 2003 Alice Bonitati, M.D. I COPD National Coalition Meeting Poster presenta- I President, Rhode Island Thoracic Society (2004-2005) tion “Roflumilast in the Treatment of COPD”, Sidney Braman, M.D. Washington, DC, November 2003 I United Nations Environment Programme (UNEP) I Asian Pacific Society of Respirology Lecturer “Vocal Medical Applications Technical Options Committee Cord Dysfunction” “COPD: Acute Exacerbation, (Appointed 4/1/05) Kuala Lumpur, Malaysia, December 2003 I Co-Chair, Global Education Council for I SEEK Editorial Board Meeting, Maui, HI, January, Respiratory Disease 2004 I American College of Chest Physicians: I World Asthma Meeting Symposium lecturer and Nominations Committee (Chairman) 2004-2005 moderator: “Novel Approaches to the Treatment of I American Thoracic Society Awards Committee Asthma and COPD - Lectures “Asthma in the (2004-2005) Elderly”,“Smoking Cessation—Western Approach”, I Member, Selection Committee, GSK Pulmonary and “Noninvasive Positive Pressure Ventilation” Fellowship Research Awards (2003-2005) Bangkok, Thailand, February 2004 I I Member of the Faculty, American College of Chest Visiting Professor, Grand Rounds “COPD— Physicians Pulmonary Board Review Course (2003- Challenges for the 21st Century” Louisiana State 2005) University, New Orleans, LA, April 2004 I I Member of the Editorial Board of SEEK - Self Grand Rounds Lecturer “Update on COPD” Sturdy assessment textbook published yearly by the ACCP Memorial Hospital, Attleboro, MA, April 2004 (2003-2005) I Lecturer, Helenic Thoracic Society “Lung Volume I Editorial Board of Clinical Pulmonary Medicine Reduction Surgery” and “The Upper Airway: The Hidden Zone”,Athens, Greece, May 2004 I Chairman, Foundation for Respiratory Disease I American Thoracic Society International I 17th Asia Pacific Congress on Diseases of the Chest, Conference Postgraduate Seminar - Chair/Speaker, 1)”Small airways obstruction - Diseases of the “The role of inflammation in COPD” and “Asthma: silent zone”,2) “COPD - Difficult Management Is this the one disease entity?”,Discussion Facilitator cases (smoking cessation, pulmonary cachexia, end - Poster Session “COPD Therapy: More Than of life…”,3) Moderator - Plenary Session “COPD”, Simple Bronchodilatation”,Orlando, FL, May 2004 4) Meet-the-Professor Seminar “Asthma - Why are we not meeting the GINA guidelines?”,5)”The I ACCP International Symposium (Chairman) “The aging lung: Clinical and physiologic consequences”, Global Burden of Asthma”,Stressa, Italy, July 2004 Istanbul, Turkey, August 2003 I ACCP SEP Board Review Course, Orlando, FL, I ACCP Pulmonary Board Review Course “Asthma” August 2004 and “COPD”,Phoenix, AZ, August 2003 I Visiting Professor, Michigan Thoracic Society, I ABIM Pulmonary SEP (Self Evaluation Process) “COPD”,Saginaw, MI, September 2004 Module, Faculty Presenter, Phoenix, AZ, August 2003 I Faculty, NIH Conference on COPD, Washington, I European Respiratory Society, “Selective PDE4 DC, September 2004 inhibitors - Novel Opportunities for the treatment of I Lovelace Research Institute Respiratory COPD and asthma”,Vienna, Austria, September 2003 Symposium, “Asthma in the elderly” and Co-Chair I 7th Annual Thomas J. Godar Pulmonary/Critical of Session, Santa Fe, NM, September 2004 Care Symposium, Saint Francis Hospital & Medical I ACCP Symposium on Asthma & COPD (Chairman) Center, “Recent advances in the management of “Underdiagnosing of COPD”,“Asthma in the elderly bronchial asthma”,Hartford, CT, September 2003 …diagnostic, pharmacologic and environmental

148 brown medical school department of medicine

issues” and Chairman of symposium on Drug Safety, I Invited speaker, American Thoracic Society 100th Seattle, WA, October 2004 International Meeting, Mini-symposium: “Expanding I ACCP Editorial Committee for Clinical Practice roles for endothelial cells in the pathogenesis of lung Guidelines on the Diagnosis and Management of disease”,Orlando, FL, May 2004 Cough, Boston, MA, November 2004 I Invited speaker, Research Seminar, “Role of PKC in I Visiting Professor, Brazilian Thoracic Society, “The endothelial barrier function”,Department of ideal inhaled corticosteroid” and “COPD: A systemic Pathology and Laboratory Medicine, Brown disease”,Salvador, Brazil, November 2004 University, Providence, RI, June 2004 I I Symposium Chair, Foundation for Respiratory Invited poster presentation, Gordon Research Disease, Miami Beach, FL, December 2004 Conference on Endothelial Cell Phenotypes in Health & Disease, “Inhibition of carboxylmethylation of Rho I GSK Research Award Committee, San Diego, CA, GTPase decreases endothelial monolayer permeabili- January 2005 ty”,Andover, NH, August 2004 I United Nations MATOC Committee Meeting, I Invited speaker, Gordon Research Conference on Caracas, Venezuela, April 2005 Endothelial Cell Phenotypes in Health & Disease, I Visiting Professor, Grand Rounds, New York “Requirement for PKC in endothelial basal barrier Methodist Hospital, “COPD in the 21st Century”, function regulation”,Andover, NH, August 2004 New York, NY, May 2005 I Invited poster presentation, Gordon Research Vera De Palo, M.D. Conference on Endothelial Cell Phenotypes in I 1st Fellows Conference on Asthma and Its Treatment: Health & Disease, “Requirement for PKC in State of the Art 2005 “Asthma epidemiology and public endothelial basal barrier function regulation”, health”,American College of Chest Physicians. Hilton Andover, NH, August 2004 Head, SC, April 2005 I Invited speaker, Pulmonary Research Seminar, “Signaling Mechanisms Involved in Endothelial Kevin Dushay, M.D. Barrier Enhancement”,Department of Pulmonary, I “Update on lung volume reduction surgery”, Critical Care & Sleep Disorder Medicine, Brown Medical Grand Rounds, Rhode Island Hospital, Medical School, Providence, RI, January 2005 Providence, RI, 2004 I Invited speaker, Research Seminar, “Signaling I “Early goal directed therapy”,Critical Care Grand Mechanisms Involved in Endothelial Barrier Rounds, Rutland Regional Medical Center, Rutland, Enhancement”,Vascular Biology Center, Medical VT, 2004 College of Georgia, Augusta, GA, March 2005 I “Update on COPD - 2004”,Medical Grand Rounds, I Invited speaker, Research Seminar, “Signaling St. Vincent Hospital, Worcester, MA, 2004 Mechanisms Involved in Endothelial Barrier I “Update on COPD - 2004”,Fall Meeting, Rhode Enhancement”,Department of Pharmacology, Island Society of Respiratory Care, Warwick, RI, 2004 Uniformed Services University of the Health I “Tracheostomy: Techniques, complications and the Sciences, Bethesda, MD, June 2005 critical role of the respiratory therapist”,Rhode James Klinger, M.D. I Island Society for Respiratory Care 21st Annual I Update on Therapeutic Approaches to the Heart Convention & Exhibition, Newport, RI, 2005 Failure Patient, Pulmonary Hypertension, Newport, Elizabeth Harrington, Ph.D. RI, September 2003 I Invited speaker, Experimental Biology, “PKC I Update in Critical Care Medicine, Diagnosing PE in enhanced microvascular endothelial barrier function: the ICU:D-dimers and CT angiogram, Providence, Involvement of RhoA GTPase signaling pathway”, RI, September 2003 San Diego, CA, April 2003 I Emerging Therapies for Pulmonary Hypertension, I Invited speaker, Research Seminar, “Role of PKC in Grand Rounds, Norwich Hospital, Norwich CT, modulation of endothelial monolayer permeability”, October 2003 Pulmonary, Critical Care and Sleep Medicine, Tufts- I Emerging Therapies for Pulmonary Hypertension, New England Medical Center, Boston, MA, May 2004 Pulmonary Rounds, Danbury Hospital, Danbury, CT, November 2003 149 pulmonary, critical care & sleep medicine

I Pulmonary Hypertension: Approach to the Surgical I ACCP CHEST 2003 Conference, Presentations: I) Patient, Visiting Professor and Grand Rounds Implementation Strategies for New Therapies in Department of Anesthesiology, Yale University ICU; II) Sepsis Treatment and Treatment School of Medicine, New Haven, CT, February 2004 Management: An Evidence-Based Review, Orlando, I Pulmonary Hypertension – Role of Brain FL, October 2003 Natriuretic Peptide. Loyola School of Medicine, I 9th International Conference: Noninvasive Lung Transplant Program, Chicago, IL, March 2004 Ventilation: From the ICU to Home. Presentations: I) I Hypoxic Respiratory Failure: what to do when Ethical Issues in Mechanical Ventilation (Chair) – traditional methods fail. 6th Annual Conference in NIV is useful at the end of life: CON; II) Ethical Case Mechanical Ventilation 2004: New Trends, Tufts/New Discussion in Acute Care, Orlando, FL, October 2003 England Medical Center, Boston, MA, April 2004 I 6th Annual Meeting Tuscany Critical Care Group, I Home Nitric Oxide Therapy for Adult Chronic Florence, Italy, October 2003 Lung Disease – iNOTherapeutics Scientific Advisory I National Institutes of Health National Heart, Lung Board Meeting, Woods Hole, MA, September 2004 and Blood Institute Working Group I Pulmonary Hypertension - David H. Spodick, I On RespiratoryFailure from SARS, Bethesda, MD, Cardiology Symposium Worcester Medical Center, October 2003 Worcester, MA, October 2004 I Toronto Critical Care Medicine Symposium 2003, I Pulmonary hypertension – Medical Grand Rounds, Toronto, Canada, October-November 2003. Charleton Memorial Hospital, Fall River, MA, I Conference on Ethical Conduct of Clinical October 2004 Research Involving Critically Ill Subjects, I Emerging Therapies in Pulmonary Hypertension, Washington, DC, November 2003 brain natriuretic peptide, inhaled nitric oxide and I VERICC Task Force meeting, Scottsdale, AZ, simvastatin. Second Annual Symposium on January 2004 Pulmonary Hypertension, Tufts University School I 10th Annual Conference of the Indian Society of of Medicine, Boston, MA, November 2004 Critical Care Medicine, Mumbai, India, February 2004 I Update in Treatment of Pulmonary Hypertension I CNN Headline News, live interview: Surviving Associated with Collagen Vascular Diseases. Sepsis & Guidelines, Atlanta, GA, March 2004 Rheumatology Grand Rounds. Roger Williams I Medical Center, Providence, RI., June 2005 3rd Annual International Summit on Innovations in Critical Care Delivery: Managing Risk and Mitchell Levy, M.D. Uncertainty, Miami, FL, March 2004 I Senior Editor, Journal of Critical Care, WB I 24th International Symposium on Intensive Care Saunders, Philadelphia, PA 2001-present and Emergency Medicine, Brussels, Belgium, I Council member, the governing body of the Society March-April 2004 of Critical Care Medicine, term 2/2002-2/2005 I American Thoracic Society International I Medical Grand Rounds, Rhode Island Hospital, Conference 2004 (faculty), Orlando, FL, May 2004 Update in Critical Care Medicine, July 2003 I Brazilian Congress of Intensive Medicine (faculty), I 9th Annual Update in Critical Care: Changing Curitiba, Brazil, June 2004 Standards of Care in the ICU: Using Evidence I 2nd Asia Pacific Centre of Excellence on Critical Care Based Medicine at the Bedside (co-chair), Interventions, Hyderabad, India, July-August 2004 Providence, RI, September 2003 I “New Insights in Mechanical Ventilation” Symposium I 7th Conference of International Trauma, (sponsored by CHEST), Monterey, CA, August 2004 Anaesthesia & Critical Care Society (Indian I Surviving Sepsis Campaign, “The Guidelines: Chapter), New Delhi, India, September 2003 Implementation for the Future, Catania, Italy, I End-of-Life Learning Community meeting, Halifax, September 2004 Nova Scotia Canada, September 2003 I CHEST 2004 annual conference (faculty), Seattle, I IMPACT Fall Learning Session (sponsored by WA, October 2004 Institute for Healthcare Improvement), Atlanta, I ESICM 17th Annual Congress, Berlin, Germany GA, October 2003 150 October 2004 brown medical school department of medicine

I 6th International Bioethics Conference, The St. I “Diaphragm ultrasonongraphy and diseases of the Francis International Center for Healthcare Ethics, chest wall. Erasmus Hospital, Brussels, Belgium, Honolulu, HI, October 2004 September 2004 I Scottish Intensive Care Society Audit Group, I “Recent advances in the treatment of COPD” Scotland, November 2004 Grand Rounds, Maine General Hospital, Waterville I Northern Irish Intensive Care Group, Belfast, ME, September 2004 Ireland, November 2004 I “Recent advances in the treatment of COPD” I Irish Intensive Care Society, Limerick, Ireland, Grand Rounds, Maine General Hospital, Augusta November 2004 ME, September 2004 I SCCM 2005 Critical Care Congress (faculty), Richard Millman, M.D. Phoenix, AZ, January 2005 I Chair, “Non-Cardiopulmonary Outcomes of Sleep I Presbyterian Saint Luke’s Medical Center, Denver Disordered Breathing”.American Thoracic Society, CO, and Penrose Hospital and Memorial Hospitals, May 2004 Colorado Springs, CO: Timing of Treatment in I “A rational approach to insomnia”,Department of High-Risk Severe Sepsis, January 2005 Psychiatry Grand Rounds, Hospital of Saint I 10th International Symposium on Infections in the Raphael, New Haven, CT, September 2004 Critically Ill Patient, Porto, Portugal, January 2005 I “Approach to the sleepy student”,New England I Puerto Rico American College of Physicians College Health Association Annual Meeting, Chapter Regional Meeting, San Juan, Puerto Rico, Portsmouth, NH, November 2004 February 2005 Linda Nici, M.D. I 25th International Congress on Intensive Care & I 2005 Appointed, Board of Directors, American Emergency Medicine, Brussels, Belgium, March 2005 Association of Cardiovascular and Pulmonary I 7th Annual Conference in Mechanical Ventilation: Rehabilitation (AACVPR) New Trends 2005, (faculty) Boston, MA, April 2005 I 2005 Appointed, Chronic Disease Management I Computers in the ICU Revisited: An Expert Task Force, AACVPR Roundtable Faculty, Chicago, IL, April 2005 I 2003 Appointed, Editorial Board, Chronic I International Consensus Conference in Intensive Care Respiratory Disease Medicine 2005: Weaning from Mechanical Ventilation I Board of Directors, American Lung Association of (faculty), Budapest, Hungary, April/May 2005 Rhode Island I Ocean State Ethics Conference, Brown University, I Committee Chair: Joint American Thoracic May 2005 Society/ European Respiratory Society Statement Qing Lu, Ph.D. on Pulmonary Rehabilitation I American Thoracic Society International Conference, I Women and Lung Cancer, American Association of Poster Presentations “Alterations in glucose regulated Cardiovascular and Pulmonary Rehabilitation, protein 94 (GRP94) upon Isoprenylcysteine carboxyl Kansas City, October 2003 methyltransferase (ICMT) inhibition” and “Signaling I Women and Lung Cancer, Yale University State mechanism involved in transforming growth factor- Chest Conference, January 2004 b1-induced endothelial barrier dysfunction”,San I The ATS-ERS Statement on Pulmonary Diego, CA, May 2005 Rehabilitation, European Respiratory Society, F. Dennis McCool, M.D. Glasgow, Scotland , September 2004 I Editor-in-Chief, LUNG 2003-present I The Cutting Edge of Clinical Pulmonary Medicine I Member, ACCP Consensus Panel on Managing in COPD, Trevi, Italy, September 2004 Cough I “Protussive Therapy”.Symposium on Cough. ACCP, Orlando, FL, October 2003

151 pulmonary, critical care & sleep medicine

Sharon Rounds, M.D. I Visiting Professor, Keio University, Tokyo, Japan. I President-Elect, American Thoracic Society, 2003-04 “Apoptosis and lung injury”,April 2005 I President, American Thoracic Society, 2004-05 I Invited Presidential Lecture, “Respiratory diseases I Immediate Past President, American Thoracic and the internal environment,” Japanese Society, 2005-06 Respiratory Society, Chiba, Japan, April 2005 I I Visiting Professor, Pulmonary Medicine, Chiba Meet the Professor, “Vascular consequences of University, Chiba, Japan, May 2004 obstructive sleep apnea”,Japanese Respiratory Society, Chiba, Japan, April 2005 I Federal Employee of the Year, Bud Gifford Leadership Award, awarded by the Federal Executive Council of I Invited Lecture, “Global lung health, the ATS per- RI, May 2004 spective”,Turkish Thoracic Society, Antalya, Turkey, April 2005 I 13th Kass Lecturer, University of Nebraska Medical Center, May 2004 I Invited Lecture, “What’s new in pulmonary hyper- tension”.ATS/SEPAR Symposium, Spanish Thoracic I Dr. David Cugell Lecturer, Department of Society (SEPAR), June 2005 Medicine, Feinberg School of Medicine, Northwestern University, February 2005 Michael L. Stanchina, M.D. I Meet the Professor, “Molecular mechanisms of lung I Invited Speaker, American College of Chest microvascular injury”,Japanese Respiratory Society Physicians, “Acute COPD exacerbations and therapy”, meeting, Tokyo, Japan, April 2004 Orlando, FL, October 2003 I Visiting Professor, Pulmonary Medicine, Chiba I Invited Young Investigator, Japanese Respiratory University, Chiba, Japan, March 2004 Society, April 2005 I Visiting Professor, 13th Kass Lecturer, University of Nicholas Ward, M.D. Nebraska Medical Center, May 2004 I International Conference Program Committee for I Invited Speaker and poster presentation, FASEB Critical Care, American Thoracic Society, 2005 Conference on Biological Methylation, Saxton’s I Program Committee for the International Summer River, Vermont, July 2004 Conference and representative for NIH Consensus I Invited Moderator, Grover Conference on the Conference on end of life research, Society of Pulmonary Circulation, Deckers, Colorado, Critical Care Medicine, 2004 September 2004 I Brown Medical School 9th Annual Critical Care I Keynote Speaker, American Lung Association of Update, Speaker: “Management of status asthmati- Maine Annual Meeting, “Toward a system of pre- cus” and “DVT prevention in ICU patients”, vention, detection, and treatment of COPD”,South Providence, RI, September 2003 Portland, Maine, September 2004 I American Association for Respiratory Care, 33rd I Invited Speaker, Brazilian Thoracic Society, Respiratory Care Journal Conference, speaker: “Mechanisms of endothelial cell injury”,and “Using clinical information systems in ICU “Pathogenesis of pulmonary hypertension”, research”,Banff, Canada, October 2003 November 2004 I Society of Critical Care Medicine, “Computers in I Invited Speaker, Asian Pacific Society for Respirology, the ICU: an expert roundtable”.Speaker/partici- “Radiology Grand Round”,Moderator: “Lung pant, Boston, MA, November 2003 cancer”,and Presidential Lecturer: “Treatment of I Harvard Medical School/Massachusetts General pulmonary hypertension: New insights and new Hospital Pulmonary Grand Rounds, speaker: hope”,December 2004 “Optimal PEEP: a fool’s errand”,Boston, MA, I Visiting Professor, Pulmonary/Critical Care Section, November 2003 Feinberg School of Medicine, Northwestern I Society of Critical Care Medicine 33rd Critical Care University, Medical Grand Rounds, “Vascular compli- Congress, Moderator: “The epithelial cell in acute cations of obstructive sleep apnea”,Research lung injury”.Speaker: “Anti-inflammatory agents in Conference, “Post-translational processing of small ALI”,San Antonio, TX, February 2004 GTPases and endothelial cell function”,February 2005

152 brown medical school department of medicine

I Society of Critical Care Medicine 33rd Critical Care I Chair of Nominations Committee, Medical Faculty Congress, Speaker: “Epithelial cell apoptosis in Executive Committee, Brown Medical School, ALI”,San Antonio, TX, February 2004 2004-2005 I Japanese Respiratory Society 44th Annual meeting. I Ad hoc Member, Respiratory Physiology Study ATS Young Investigator/Presenter. “Validation of Section, Pathophysiological Sciences Integrated simplified method for determining optimal PEEP Review Group, NIH NHLBI, 6/2003 in patients with ARDS”,Tokyo, Japan, April 2004 I Associate Editor, Lung, 2003-present. I American Thoracic Society 100th International I Ad hoc Member, Respiratory Integrative Biology Conference, Poster discussion: “Using decremental and Translational Research Study Section, NIH PEEP curves to set optimal PEEP”,Orlando, FL, NHLBI, 3/2004 May 2004 I Member, Assembly on Pulmonary Circulation, I Society of Critical Care Medicine, Clinical Planning Committee, American Thoracic Society, Information Systems in the ICU 2nd Annual Expert 2005 Roundtable. Participant/speaker: “Using clinical information Systems to change physician practice”, James Klinger, M.D. Chicago, IL, April 2005 I Study Section, Northeast Research Consortium, American Heart Association, 2003 I Tufts University School of Medicine, 7th Annual Conference on Mechanic Ventilation. Speaker, I Program Committee, Assembly on Pulmonary “Molecular biology of mechanical ventilation: Circulation, American Thoracic Society, 2003 Ready for the bedside?”,April 2005 I Manuscript reviewer: Chest, Circulation, Circulation I American Thoracic Society 101st International Research, Clinical Science, Future Cardiology, Conference, “Monitoring patients in the ICU” Hypertension, Journal of Applied Physiology, Journal (postgraduate course), San Diego, CA, May 2005 of Critical Illness, European Journal of Clinical Microbiology & Infectious Disease, American Journal of I American Thoracic Society 101st International Conference, Chairman: Minisymposium, “Molecular Physiology: Lung Cellular and Molecular Physiology, markers of sepsis”,San Diego, CA, May 2005 American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, and American Journal of I American Thoracic Society 101st International Respiratory Cell and Molecular Biology Conference, Speaker/moderator: “Accuracy of clinical information systems in ICU research”,San Qing Lu, Ph.D. Diego, CA, May 2005 I Alternate Member, Research & Development Committee, Providence VA Medical Center, 2004- RESEARCH AND OTHER 2005 SCHOLARLY ACTIVITIES I Member, Research & Development Committee, Providence VA Medical Center, 1/2005-present Member, Institutional Animal Care and Use FACULTY MEMBERS OF STUDY SECTIONS AND Committee (IACUC), Providence VA Medical ADVISORY COMMITTEES Center, 1/2005-present Sidney Braman, M.D. I Manuscript reviewer for: LUNG, FASEB Journal, See National/International Honors and Recognition American Journal of Respiratory Cell and Molecular Section Biology and Physiology Research

Kevin Dushay, M.D. Richard Millman, M.D. I Elected to the American College of Chest Physicians I NHLBI National Center on Sleep Disorders Critical Care NetWork Steering Committee Research I Co-Chair, Working Group on Sleepiness in Elizabeth Harrington, Ph.D. Adolescents and Young Adults 2001-2004 I Member, Medical Faculty Executive Committee, Brown Medical School, 2003-2006 I National Center for Research Resource, Clinical Research Center Site Reviewer, 2003

153 pulmonary, critical care & sleep medicine

Linda Nici, M.D. F. Dennis McCool, M.D. I Scientific Advisory Board, AACVPR, 2005 I 2004 Brown University Dean’s Teaching Excellence Award Sharon Rounds, M.D. I American Heart Association Annie Lin Parker, M.D. I I Member, Great America Peer Review Committee, 2003 Dean’s Teaching Excellence Award Lung and Cardiorenal, 7/99-6/2001 Francis Sharon Rounds, M.D. Families Foundation I Brown University Dean’s Teaching Excellence I Member, Scientific Advisory Board for Parker B. Award, 2003-2004 Francis Foundation Fellowships, 2000-2005 Patricia Russo-Magno, M.D. I Editorial Boards: Journal of Molecular and Cell I Physiology, 2003-present American Journal of Excellence in Teaching Award, Memorial Hospital Respiratory and Critical Care Medicine, 2005-present of RI

Eleanor Summerhill, M.D. Eleanor Summerhill, M.D. I Dean’s Teaching Excellence Award I Elected to the American College of Chest Physician’s Critical Care NetWork Steering Committee Nicholas S. Ward, M.D. I 2003 Brown University Dean’s Teaching Excellence TEACHING ACTIVITIES Award I 2004 Brown University Dean’s Teaching Excellence EDUCATION HONORS Award

Alice E. Bonitati, M.D. TEACHING RESPONSIBILITIES I 2005 Brown University Excellence in Teaching Award Muhanned Abu-Hijleh, M.D. Vera De Palo, M.D. I Attending Teaching Rounds - Pulmonary consultation I 2003-2004 Teaching Recognition Award - Brown service, MICU and neurosurgical ICU University Family Medicine Residency Program I Lecturer - Introductory Lecture Series for new American Academy of Family Physicians pulmonary/critical care medicine fellows I 2004 Dean’s Teaching Excellence Award, Brown I Brown University Chest Conference Medical School - Biomed 281 I Lecturer - Biomed 281: Pulmonary Kevin Dushay, M.D. Pathophysiology I 2004 Brown University Dean’s Teaching Excellence I Mentor for student discussion groups - Biomed 281 Award Alice Bonitati, M.D. I 2005 Brown University Dean’s Teaching Excellence I Preceptor, Medical Resident, Brown Community- Award Based Teaching Program I 2005 Brown Medical School Division of I Preceptor, Sleep Medicine Clinic Pulmonary, Sleep and Critical Care Medicine I Preceptor, Pulmonary Fellows in Office Practice Teacher of the Year Award I Lecturer - Introductory Lecture Series for new I 2005 Brown Medial School Department of pulmonary/critical care medicine fellows Medicine Attending Teaching Award I Lecturer - Brown University Summer Program I 2005 Brown Medical School Department of Medicine Chairman’s Award for Outstanding Teaching I Attending Teaching Rounds - Respiratory Intensive Care Unit Brian Kimble, M.D. I Elective 329 (Pulmonary Diseases) Teaching I 2004 Brown University Dean’s Teaching Excellence Attending Award I Brown University Chest Conference

154 brown medical school department of medicine

Sidney Braman, M.D. Kevin Dushay, M.D. I Lecturer - Introductory Lecture Series for new I Section Leader - Biomed 281 Pulmonary pulmonary/critical care medicine fellows Pathophysiology I Lecturer - Housestaff Medical Noon Conference I 2004-2005 Pulmonary Section Director, BioMed I Monthly Chief’s Rounds lectures for all fellows 350 - Integrative Pathophysiology/Pharmacology, Brown University I Preceptor, Pulmonary Clinic I Lecturer - Introductory Lecture Series for new pul- I Preceptor, Pulmonary Fellows in Office Practice monary/critical care medicine fellows I Elective 329 (Pulmonary Diseases) Teaching Attending I Brown University Chest Conference I Brown University Chest Conference Allan Erickson, M.D. E. Jane Carter, M.D. I Attending Teaching Rounds - Pulmonary I Lecturer - Introductory Lecture Series for new pul- Consultation Service and Medical Intensive Care Unit monary/critical care medicine fellows I Lecturer - Medical Noon Conference I Preceptor for the Tuberculosis Clinic (Pulmonary, I Brown University Chest Conference infectious disease and pediatric Infectious disease fellows) I Medicine Clerkship at the VAMC—Chest radiology teaching conference series I Lecturer - Housestaff Conferences at Rhode Island Hospital, Miriam Hospital and the VA Medical Elizabeth Harrington, Ph.D. Center on tuberculosis I Lecturer - Biomed 285: Research Topics in I Brown University Chest Conference Pathobiology ( Seminar)

William Corrao, M.D. Brian Kimble, M.D. I Attending Teaching Rounds - Respiratory Intensive I Attending Teaching Rounds - Pulmonary Care Unit Consultation Service and Medical Intensive Care Unit I Brown University Chest Conference I Lecturer - Medical Noon Conference I Brown University Chest Conference Vera De Palo, M.D. I I Lecturer - Introductory Lecture Series for new pul- Small Group Leader - Biomed 281: Pulmonary monary/critical care medicine fellows Pathophysiology I I Lecturer - Critical Care Lecture Series at RIH Physical Diagnosis course instructor at VAMC I Attending Teaching Rounds - Medical Intensive James Klinger, M.D. Care Unit & Pulmonary Service I Lecturer - Introductory Lecture Series for new pul- I Biomed 281: Pathophysiology: Lecturer, small monary/critical care medicine fellows group leader; Director of the Pulmonary Section, I Lecturer - Critical Care Lecture Series and Director Pathophysiology Course I Lecturer - Housestaff Medical Noon Conference I Biomed 301: Clerkship in Medicine: Preceptor and I Attending Teaching Rounds - Medical Intensive lecturer Care Unit, Pulmonary Consultation Service and I Biomed 337: Intensive Care Medicine (Memorial): Respiratory Intensive Care Unit. Director I Electives 329 & 334 (Pulmonary Diseases and I Biomed 350: Integrative Medical Intensive Care) Teaching Attending Pathophysiology/Pharmacology-Section 1 course I Brown University Chest Conference leader I Mentor for Brown Summer Research Early I Brown University Chest Conference Identification Program I Women In Medicine Mentor Program I Co-Director, Biomed 209 Respiratory Walter Donat, M.D. I Brown Medicine in Action Program-shadowing I Attending Teaching Rounds - Respiratory Intensive program for undergraduates Care Unit I Supervisor for house officer research project I Brown University Chest Conference 155 pulmonary, critical care & sleep medicine

Mitchell Levy, M.D. I Pulmonary Mentor for Medicine Residents during I Lecturer - Introductory Lecture Series for new their elective Inpatient Pulmonary rotations. pulmonary/critical care medicine fellows I General Medical Attending for Medical Students, I Lecturer - Housestaff Medical Noon Conference Internal Medicine Residents and Family Care I Clerkship Coordinator for MICU elective for I Pulmonary Mentor for Pulmonary Clinical Fellows Brown medical students I Lecturer for Internal Medicine Noon Conferences I Attending Teaching Rounds - Medical Intensive I Pulmonary Mentor for Pulmonary Research Fellows Care Unit for medical residents/fellows I Pulmonary Mentor for Medicine Residents during I Lecturer - Critical Care Lecture Series their elective Pulmonary outpatient rotations I Elective 334 (Medical Intensive Care) Teaching Attending Richard Millman, M.D. I Course Director, “Sleep and College Students: I Medical Informatics - Teach medical skills to all Problems and Solutions”,Newport, RI, May 7-8, 2004 Internal Medicine housestaff; introduce clinical I information systems in the ICU to all housestaff; Lecturer - Introductory Lecture Series for new teach severity scoring and automated data entry to pulmonary/critical care medicine fellows housestaff and medical students I Lecturer - Housestaff Medical Noon Conference I Ethics Lectures - MICU ethics conference every I Attending Teaching Rounds - Respiratory Intensive month coordinated with nursing Leadership Care Unit I Electives 329 & 334 (Pulmonary Diseases and Qing Lu, Ph.D. Medical Intensive Care) Teaching Attending Research Trainees: I Brown University Chest Conference I Noelle Hutchins, Summer Research Student, 6/04- 8/04. Class of 2005, University of North Carolina. Annie Lin Parker, M.D. I Zhizhan Gu, research rotation, 6/04-8/04. Ph.D. I Lecturer - Introductory Lecture Series for new pul- student, Department of Molecular Pharmacology, monary/critical care medicine fellows Physiology, and Biotechnology, Brown Medical I Lecturer, Group Leader and Director - Biomed 281: School Pulmonary Pathophysiology I Nicole Morin, Research Assistant, 1/02-1/05. I Lecturer - Resident Teaching Conferences Department of Surgery, Brown Medical School I Attending Teaching Rounds - Pulmonary I Heather Rowlett, Research Assistant, 1/05-present. Consultation Service and Medical Intensive Care Providence VA Medical Center Unit I Thomas Kim, Summer Research Assistant, 6/05- I Brown University Chest Conference 8/05. BS candidate, Brown Medical School Sharon Rounds, M.D. F. Dennis McCool, M.D. I Attending Teaching Rounds - Internal Medicine I Lecturer - Introductory Lecture Series for new pul- Service, Pulmonary Consultation Service, and monary/critical care medicine fellows Medical Intensive Care Unit I Brown University Chest Conference I Brown University Chest Conference I Lecturer/Preceptor - Introduction to Clinical I Lecturer - Introductory Lecture Series for new Medicine Biomed 373 pulmonary/critical care medicine fellows I Director - Pulmonary Clerkship Memorial Hospital Biomed 314B Michael L. Stanchina, M.D. I Course Director & Lecturer - Sleep Medicine I Group Leader - Integrated Medical Sciences, Lecture Series Respiratory Pathophysiology Biomed 281 I Course Co-Director, “Sleep and College Students: I Lecturer - Integrated Medical Sciences, Respiratory Problems and Solutions”,Newport, RI, May 2004 Pathophysiology Biomed 281 I Lecturer - Introductory Lecture Series for new pul- I Group Leader - Respiratory Physiology Biomed 117 monary/critical care medicine fellows

I 156 Lecturer - Housestaff Medical Noon Conference brown medical school department of medicine

I Brown University Chest Conference I Co-Director - Critical Care/Emergency Medicine I Lecturer - Physical Diagnosis Course Conference I I Lecturer - Respiratory Physiology Course (Fellows) Lecturer - Housestaff Medical Noon Conference I Lecturer - Critical Care Lecture Series Tihomir Stefanec, M.D. I Attending Teaching Rounds: Pulmonary I Attending Teaching Rounds - Pulmonary Consultation Service, Medical Intensive Consultation Service I Care Unit and Respiratory Intensive Care Unit I Brown University Chest Conference teaching fellows, residents and students Eleanor Summerhill, M.D. I Lecturer - Biomed 281: Pulmonary Pathophysiology I Lecturer - Introductory Lecture Series for new I Elective 334 (Medical Intensive Care) Teaching pulmonary/critical care medicine fellows Attending I Brown University Chest Conference I Preceptor - Internal Medicine Clerkship 2004-2005 I Director, Internal Medicine Residency Program, I Course Director - Critical Care Elective/Rhode Memorial Hospital/Brown Medical School Island Hospital 2002-2005 Nicholas Ward, M.D. I Subspecialty Education Coordinator - Brown I Associate Fellowship Program Director, Brown Medical School, Department of Medicine 2004-2005 University School of Medicine, Department of I Brown University Chest Conference Pulmonary, Critical Care, and Sleep Medicine I Lecturer - Introductory Lecture Series for new pul- monary/critical care medicine fellows

PULMONARY/CRITICAL CARE FELLOWSHIP PROGRAM

Departing Fellows

Name Medical School Residency Postgraduate Plans Jason Aliotta, M.D. Tufts University Beth Israel Deaconess Currently affiliated with Medical Center Roger Williams Medical Center Michael Baram, M.D. Jefferson Medical College Christiana Care Health Currently in private System, Newark, DE practice in Wilmington, DE Gerardo Carino, M.D., Ph.D. Brown University Brown Medical School Currently affiliated with Internal Medicine (RIH) Miriam Hospital Charles Lee, M.D. Jefferson Medical College Brown Medical School Currently affiliated with Internal Medicine (RIH) Rhode Island Hospital Michael Ryan, M.D. Medical College of Virginia Medical College of Virginia Currently in private practice in San Luis Obispo, CA Daniel Sousa, M.D. University of Vermont Brown Medical School Currently in private Internal Medicine (RIH) practice in Fall River, MA

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PULMONARY/CRITICAL CARE FELLOWSHIP PROGRAM

Current Fellows

Name Medical School Residency Brian Casserly, M.D. University College Dublin Tufts New England Medical Center Chee Chan, M.D. Albany Medical College UMDNJ University Hospital Yaser Abu El-Sameed, M.D. University of Jordan Cleveland Clinic Foundation Sam Faradyan, M.D. George Washington University St. Elizabeth Medical Center Theresa Glidden, M.D. University of Massachusetts University of Massachusetts Brian Horner, D.O. UMDNJ/School of Osteopathic Medicine Temple University Hospital Matthew Jankowich, M.D. Ohio State University Beth Israel Deaconess Medical Center Patrick Keaney, M.D. Medical College of Virginia Beth Israel Deaconess Medical Center Melissa Lee, M.D. SUNY Buffalo Brown Medical School Internal Medicine (RIH) Kevin Martin, M.D. University of Rochester Beth Israel Deaconess Medical Center Michael Polsky, M.D. University of Florida Brown Medical School Internal Medicine (RIH) Andrew Stone, M.D. University of Vermont Brown Medical School Internal Medicine (RIH)

SELECTED PUBLICATIONS Vera De Palo, M.D. I Narasimhan M, Posner AJ, DePalo VA, Mayo P, Muhanned Abu-Hijleh, M.D. Rosen MJ. Intensive care of patients with HIV I Parker AL, Abu-Hijleh MA, McCool FD. Ratio infection in the era of highly active antiretroviral between forced expiratory flow between 25% and therapy. Chest 2004; 125(5):1800-4. 75% of vital capacity and FVC is a determinant of I DePalo VA, Parker AL, Al-Bilbeisi F, McCool FD. airway reactivity and sensitivity to methacholine. Respiratory muscle strength training with non-respi- Chest 2003; 124(1):63-69 ratory maneuvers. J Appl Physiol 2004; 96(2):731-4. I DePalo VA. Pulmonary Disease: Pneumonia, Alice Bonitati, M.D. COPD, Asthma and thromboembolic disease. J Am I Liesching TN, Carlisle C, Marte A, Bonitati AE, Pod Med Assoc 2004; 94(2):157-67. Millman RP. Evaluation of the accuracy of SNAP technology sleep sonography in detecting obstruc- Elizabeth Harrington, Ph.D. tive sleep apnea in adults compared to standard I Harrington EO, Brunelle JL, Shannon CJ, Kim, ES, polysomnography. Chest 2004; 125(3):886-891. Mennella K, Rounds S. Role of protein kinase C isoforms in rat epididymal microvascular endothe- Sidney Braman, M.D. lial barrier function. Am J Respir Cell Mol Biol 2003; I Capitano B, Mattoes H, Shore E, O’Brien A, 28:626-636. Braman SS, Sutherland C, Nicolau DP. Steady-state intrapulmonary concentrations of moxifloxacin, I Lu Q, Harrington EO, Hai CM, Newton J, Garber levofloxacin, and azithromycin in older adults. M, Hirase T, Rounds S. Isoprenylcysteine carboxyl Chest 2004; 125(3):965-973. methyltransferase modulates endothelial monolayer permeability: Involvement of RhoA carboxyl Kenneth Casey, M.D., M.P.H. methylation. Circ Res 2004; 94:306-315. I Meoli AL, Rosen C, Kristo D, Black J, Kohrman M, I Tsikitis VL, Morin NA, Harrington EO, Albina JE, Goonerate N, Aguillard RN, Fayle RW, Troell RJ, Reichner JS. The lectin-like domain of complement Kramer R, Casey KR, Coleman JA. Upper airway receptor 3 protects endothelial barrier function management of the adult patient with OSA in the from activated neutrophils. J Immunol 2004; perioperative period—avoiding complications. 173:1284-1291. Clinical Practice Review Committee, AASM. Sleep 158 2003; 26(8):1060-1065. brown medical school department of medicine

I Harrington EO, Newton J, Morin N, Rounds S. I Liesching TN, Carlisle C, Marte A, Bonitati A, Barrier dysfunction and RhoA activation are blunt- Millman RP. Evaluation of the Accuracy of SNAP® ed by homocysteine and adenosine in pulmonary Technology Sleep Sonography in Detecting endothelium. Am J Physiol 2004; 287:L1091-L1097. Obstructive Sleep Apnea in Adults Compared to Standard Polysomnography. Chest 2004; 125: 886-891. James Klinger, M.D. I Aloia MS, Arnedt JT, Smith L, Skrekas J, Stanchina I Preston IR, Hill NS, Gambardella LS, Warburton M, Millman RP. Examining the construct of depres- RR, Klinger JR. Synergistic effects of ANP and sion in obstructive sleep apnea syndrome. Sleep sildenafil on cGMP levels and amelioration of acute Med 2005; 6: 115-21. hypoxic pulmonary hypertension. Exp Biol Med 2004; 229:920-5. I Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in I Steiner MK, Preston IR, Klinger JR, Hill NS. flexible versus standard continuous positive airway Pulmonary hypertension: inhaled nitric oxide, pressure therapy. Chest 2005; 127: 2085-2093. sildenafil and natriuretic peptides. Curr Opin Pharmacol 2005; 5:245-50. I Millman RP, The Working Group on Sleepiness in Adolescents/Young Adults and AAP Committee on Mitchell Levy, M.D. Adolescence. Excessive sleepiness in adolescents and I Levy MM, Abraham E, Zilberberg M, MacIntyre young adults: causes, consequences and treatment NR. A descriptive evaluation of transfusion prac- strategies. Pediatrics 2005; 115:1774-1786. tices in patients receiving mechanical ventilation. Chest 2005; 127:928-935. Linda Nici, M.D. I Nici L, Monfils B, Calabresi P. The Effects of Qing Lu, Ph.D. Taurolidine on Human Malignant Mesothelioma. I Lu Q, Harrington EO, Hai C-M, Newton J, Garber Clin Cancer Res. 10(22):7655-61, 2004. M, Hirase T, Rounds S. Isoprenylcysteine carboxyl I Nici L. Pulmonary Rehabilitation in the Treatment methyltransferase modulates endothelial monolayer of Chronic Respiratory Disease. Business Briefings: permeability: involvement of RhoA carboxyl US Respiratory Care 2005, Touch Briefings, London, methylation. Circ Res 2004; 94:306-315. U.K. 2005.

F. Dennis McCool, M.D. Annie Lin Parker, M.D. I Stone AC, Nolan S, Abu-Hijleh M, McCool FD, Hill I Parker AL. Aging dose not affect beta-agonist respon- NS. A novel form of manually-assisted ventilation. siveness after methacholine-induced bronchocon- Chest 2003; 123(3): 949-952. striction. J Am Geriatr Soc 2004; 52(3):388-392. I Parker AL, Abu-Hijleh M, McCool FD. Ratio I DePalo VA, Parker AL, Al-Bilbeisi F, McCool FD. between forced expiratory flow between 25% and Respiratory muscle strength training with non-respi- 75% of vital capacity and FVC is a determinant of ratory maneuvers. J Appl Physiol 2004; 96(2):731-734. airway reactivity and sensitivity to methacholine. I Parker AL. Airway reactivity is a determinant of Chest 2003; 124(1): 63-69. bronchodilator responsiveness after methacholine- I Rehan VK, McCool FD. Diaphragm dimensions of induced bronchoconstrictoin. J Asthma 2004; the healthy term infant. Acta Paediatric 2003; 41(6):671-677. 92(9):1062-7. I Parker AL, Abu-Hijleh M, McCool FD. I DePalo VA, Parker AL, Al-Bilbeisi F, McCool FD. FEF25075/FVC rato and airway reactivity. Letter to Respiratory muscle strength training with non-respi- the Editor. Chest 2004; 125:797-798. ratory maneuvers. J Appl Physiol 2004; 96(2): 731-734. I Parker AL. Book Review. Principles of Pulmonary Richard Millman, M.D. Medicine, Fourth Edition. Lung 182(3):197-198, 2004. I Sharkey KM, Bearpark HM, Acebo C, Millman RP, Sharon Rounds, M.D. et al. Effects of menopausal status on sleep in mid- I Kramer K, Harrington EO, Bellas R, Newton J, life women. Behav Sleep Med 2003; 1(2): 69-80. Sheahan KL, Rounds S. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. Mol Biol Cell 2003; 14:848-857. 159 pulmonary, critical care & sleep medicine

I Harrington EO, Brunelle JL, Shannon CJ, Kim ES, I Stanchina ML, Levy MM. Vasoactive drug use in Mennella K, Rounds S. Role of PKC isoforms in rat septic shock. Semin Respir Crit Care Med, 2004; epidydimal microvascular endothelial barrier func- 25(6):673-681. tion. Am J Respir Cell Mol Biol 2003; 28:626-636. I Aloia MS, Stanchina ML, Arnedt JT, Malhotra A, I Lu Q, Harrington EO, Hai C-M, Newton J, Garber Millman RP. Treatment adherence and outcomes in M, Rounds S. Isoprenylcysteine carboxyl methyl- flexible versus standard continuous positive airway transferase (ICMT) modulates endothelial mono- pressure therapy. Chest 2005; 127(6):2085-2093. layer permeability: involvement of RhoA carboxyl methylation. Circ Res 2004; 94:306-315. Nicholas S. Ward, M.D. I Ward NS, Snyder J, Ross S, Haze D, Levy MM. I Harrington EO, Newton J, Morin N, Rounds S. Comparison of a commercially available clinical Barrier dysfunction and RhoA activation are blunted information system with other methods of measuring by homocysteine and adenosine in pulmonary ICU outcomes data. J Crit Care 2004; 19(1):10-15. endothelium. Am J Physiol:Lung Mol Cell Physiol. I 2004; 287:L1091-L1097. Ward NS. Using computers in ICU research. Respir Care 2003; 49(5):487. Michael Stanchina, M.D. I Ward NS. The accuracy of clinical information sys- I Malhotra A, Trinder J, Fogel R, Stanchina ML, Patel tems (a Review) J Crit Care 2004; 19(4):121-124. SR, Schory K, Kleverlaan D, White DP. Postural effects Listings are limited to the 5 most recent publications per on pharyngeal protective reflex mechanisms. Sleep faculty member. 2004; 27:1105-1112.

RESEARCH

Direct Indirect Total

Total Basic Research Expenses Academic Year 2003 $446,046 $0 $446,046 for Pulmonary, Critical Care & Sleep Med. Academic Year 2004 $766,400 $0 $766,400

Total Clinical Research Expenses Academic Year 2003 $460,213 $85,513 $545,726 for Pulmonary, Critical Care & Sleep Med. Academic Year 2004 $650,329 $175,478 $825,807

BASIC RESEARCH I Rho and Ras GTPase and Lung Endothelial Cell Function. Department of Veterans Affairs - Merit Elizabeth Harrington, Ph.D. Review I Endothelium Barrier Function Modulation by PKCdelta. National Institutes of Health CLINICAL RESEARCH I Signaling Mechanisms Regulating Hypoxic Pulmonary Microvascular Endothelium - Project Sidney Braman, M.D. 0005. Department of Veterans Affairs - Merit Review I A Randomized Double Blind Placebo Controlled Parallel Group Trial Assessing Rate of Decline of Sharon Rounds, M.D. Lung Function with Tiotropium 18 Mcg Capsule I Rho and Ras GTPase and Lung Endothelial Once Daily in Patients with Chronic Obstructive Apoptosis. National Institutes of Health Pulmonary Disease (COPD). Boehringer Ingelheim I Focal Adhesion Complexes and Lung Endothelial Apoptosis. National Institutes of Health James Klinger, M.D. I Prospective Study of the Transition from Intravenous I Short Term Training for Minority Students. National Institutes of Health Epoprostenol to Subcutaneous Treprostinil, New England Medical Center/United Therapeutics

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I A Long-term Study of Ambrisentan in Pulmonary I Clinical Coordinating Center for a Phase 3, Multi- Arterial Hypertension Subjects having completed center, Randomized, Placebo-Controlled, Double- AMB-320 or AMB-321. Myogen, Inc. Blind, Three-Arm Study to Evaluate the Safety and I Pulmonary Hemodynamic Effects of B-Type Efficacy of Tifacogin (Recombinant Tissue Factor Natriuretic Peptide Infusion in Patients with Pathway Inhibitor) Administration in Subjects with Pulmonary Arterial Hypertension. Scios Nova, Inc. Severe Community Acquired Pneumonia. Chiron Corporation I Development of a Hospital-Based Program for the use of Nitric Oxide for Inhalation in the Chronic I ICU Peer Group for End-of-Life Care. Robert Management of Severe Cardiopulmonary Diseases. Wood Johnson Foundation INO Therapeutics, Inc. I Measuring the Quality of End-of-Life Care in the I A Phase III, Randomized, Double-Blind, Placebo- Intensive Care Unit. Robert Wood Johnson Controlled, Multi-center, Efficacy Study of Foundation Ambrisentan in Subjects with Pulmonary Arterial Richard Millman, M.D. Hypertension. Myogen, Inc. I Motivating Adherence to CPAP in Obstructive I A Multi-Center, Open Label, 8 Week Evaluation of Sleep Apnea. NIH Topital/Systemic Anti-Inflammatory Pre-Treated or I Sleep Apnea in Look AHEAD Participants. Catheter Pre-Placement on the Infusion Site NIH/NHLBI Reaction Associated with Subcutaneous Remodulin Administration. United Therapeutics Michael Stanchina, M.D. I A Randomized Double-Blind, Placebo-Controlled Mitchell Levy, M.D. Trial of Prophylactic Heparin in Patients with I A Phase 3, Multi-center, Randomized, Placebo- Severe Sepsis and Higher Severity Who are Controlled, Double-Blind, Three-Arm Study to Undergoing Treatment with Drotrecogin Evaluate the Safety and Efficacy of Tifacogen Alfa(Activated). Eli Lilly and Company (Recombinant Tissue Factor Pathway Inhibitor) I Administration in Subjects with Severe OSA And Endothelium. Lifespan Development Grant Community-Acquired Pneumonia. Chiron I Cardiac Pacing and Sleep Disorder Breathing. Corporation St. Jude Medical

I Evaluation of Efficacy and Safety of Epoetin Alfa in Nicholas Ward, M.D. Critically III Subjects. Johnson & Johnson I The Role of Activated Protein C in the Interventional Systems Compensatory Anti-inflammatory Response. Eli I Evaluation of PEEP Titration in Acute Lung Injury. Lilly and Company Siemens-Elema AB I Early Goal Directed Therapy - Collaborative ED/ICU Protocol Study. Edwards Lifesciences I A Double Blind, Placebo Controlled, Study of E5665, a Lipid Antogonist, Administered by Twice Daily Intravenous Infusions in Patients with Severe Sepsis. EISAI, Incorporated

161 rheumatology

RHEUMATOLOGY OVERVIEW

he Division of Rheumatology has enjoyed a reputation for strong clinical activities and Texcellence in teaching. Teaching by faculty in the Division of Rheumatology has focused on the Fellowship Training Program, Internal Medicine Residency and the Second Year Pathophysiology Course at Brown Medical School. Teaching by the members of the faculty in Rheumatology has also included Medical Grand Rounds, House Staff Conferences, board review courses, and Morbidity and Mortality Conference participation. For many years, the Division of Rheumatology has been an active participant in the Rheumatology Fellowship-Training Program. This program, until 1998, was a Brown Medical School- affiliated Rheumatology Fellowship Program based at the Roger Williams Medical Center. The component hospitals included the Roger Williams Medical Center, The Providence VA Medical Center and Rhode Island Hospital. Single faculty existed for many years between these 3 hospitals under the heading of the Division of Rheumatology. Between 1988 and 1998 the Director of the Division of Rheumatology was Dr. Edward V. Lally. Edward Lally, MD, Associate Professor of Medicine; He was also the Director of the Rheumatology Director, Division of Rheumatology Fellowship-Training Program at Brown. Committee at Rhode Island Hospital approved the In 1998, the Brown Medical School disaffiliated from ACGME application for the Division of Rheumatology the Roger Williams Medical Center and the to apply for fellowship status. At the time of this report, Rheumatology Fellowship Training Program that was the application is pending consideration. based there became affiliated with the Boston University The Division of Rheumatology has entered into a School of Medicine. Rhode Island Hospital was an significant period of growth and expansion. The active participant in this fellowship-training program. Division’s offices will be expanded during the latter Fellows routinely rotated at the Rhode Island Hospital, part of 2005. Dr. Lally has been directly charged with seeing consults and attending the Rheumatology Clinic recruiting additional faculty to the Division of under the supervision of Dr. Stuart T. Schwartz and Rheumatology. This includes individuals with strong more recently, Dr. Wendy Silversmith. clinical interests as well as basic scientists within the Within the past year, significant changes have taken Division. Dr. Wing has provided substantial support for place within the Division of Rheumatology. Dr. these endeavors. Dr. Lally is currently in a strong mode Schwartz has maintained his excellent reputation as cli- of recruitment to expand the Division and achieve a nician and teacher within the Division. Dr. Wendy high standard of excellence in the area of clinical Silversmith has left as of January 2005. In addition, Dr. research, basic research and other scholarly activities. Lally was recruited to become the Director of the The Rheumatology Fellowship that will be based at Division of Rheumatology beginning March 1, 2005. Rhode Island Hospital will use the Providence VA Dr. Lally has been charged with reconstituting the Medical Center and the Roger Williams Medical Rheumatology Fellowship Training Program as a Brown Center as training sites. The Division is committed to affiliated program based at Rhode Island Hospital. In high standards of excellence in research by the the spring of 2005, the Graduate Medical Education rheumatology trainees. It is the expectation that with 162 brown medical school department of medicine

academic growth the Division will be very com RESEARCH AND OTHER petitive in recruiting future rheumatology fellows. SCHOLARLY ACTIVITIES The Division of Rheumatology is currently fostering The Division of Rheumatology is an active participant strong collaborations within the Department of in the Scleroderma Clinical Trials Consortium, a multi- Medicine as well as other departments. Dr. Lally has a center international therapeutics group, investigating strong clinical interest in scleroderma and systemic newer treatments for scleroderma. Dr. Lally will also be lupus erythematosus. He will be establishing collabora- working with Dr. James Klinger in the Division of tions with the Division of Pulmonary Medicine and Pulmonary Medicine on further studies and research in Division of Cardiology related to clinical research with the field of pulmonary hypertension as it relates to these medical sub-specialties. Furthermore, it is Dr. scleroderma and other connective tissue diseases. Lally’s expectation that the Division will collaborate with the Department of Orthopedic Surgery to develop There is an ongoing trial with Dr. Vincent Falanga a musculoskeletal center. Dr. Michael Ehrlich, the at Roger Williams Medical Center investigating Chairman of the Department of Orthopedic Surgery, non-healing ulcers in the setting of scleroderma. has been supportive of this type of collaboration. Currently there are ongoing discussions to bring this TEACHING ACTIVITIES type of effort to fruition. It is also the expectation of the Division Director that collaborations will be established The Division of Rheumatology is directly responsible with other institutions including the Brown Medical for teaching the Supporting Structures course at School, Women & Infants Hospital and Hasbro Brown Medical School. This is a second year patho- Children’s Hospital. physiology course consisting of Rheumatology, Orthopedic Surgery and Dermatology. Dr. Schwartz FACULTY MEMBERS has been a course director for this course and has received outstanding evaluations by the students in the second year of medical school. In addition, the FULL TIME FACULTY (Hospital or Foundation Based) teaching activities will continue to involve the Edward V. Lally, MD, Director, Division of Fellowship Program primarily but also the elective for Rheumatology, Associate Professor of Medicine, internal medicine residents, family practice residents, Brown Medical School, University Medicine and medical students. Foundation As mentioned, the faculty of the Division of Stuart Schwartz, MD, Clinical Assistant Professor, Rheumatology not only attend on the Medical Service Rhode Island Hospital, University Medicine but provide teaching at monthly house staff confer- Foundation. ences, board review courses, Morbidity and Mortality VOLUNTEER FACULTY conferences and Medical Grand Rounds. Yousaf Ali, M.D., Clinical Instructor, Rhode Island Hospital CLINICAL RESEARCH John Conte, M.D., Clinical Assistant Professor, Rhode Island Hospital Stuart Schwartz, M.D. Harold Horwitz, M.D., Clinical Assistant Professor, I Rheumatoid Arthritis DMARD Intervention and Miriam Hospital Utilization Study, Immunex Corporation

ADJUNCT FACULTY Bernard Zimmermann, M.D., Adjunct Associate Professor, Roger Williams Medical Center Nuha Said, MD, Roger Williams Medial Center Harold A. Hall, MD, Roger Williams Medical Center Ali Yalcindag, MD, Director, Pediatric Rheumatology, Hasbro Children’s Hospital

163 rheumatology

FACULTY TRANSITIONS

New Faculty

Name Former Position Faculty Rank Edward V. Lally, MD, Director, Division of Rheumatology, Associate Professor of Medicine, Roger Williams Medical Center Brown Medical School Departing Faculty

Name Former Position New Position Wendy Silversmith, MD University Medicine Foundation Private Practice Academic Practice, Division of Rheumatology, Westerly, RI Rhode Island Hospital

RHEUMATOLOGY FELLOWSHIP PROGRAM Departing Fellows

Name Medical School Residency Post-Graduate Plans Harold A. Hall, MD Chicago Medical School Brown Medicine Program, Faculty at Roger Williams Roger Williams Medical Center Medical Center

Present Fellows Name Medical School Residency Irene Orzano, MD Georgetown University Brown Medicine Program, Rhode Island Hospital School of Medicine Lori Lieberman, MD MCP/Hahnemann School Brown Medicine Program, Rhode Island Hospital of Medicine Michelle Costa, DO University of North Texas Health Brown University, Memorial Hospital of Rhode Island Science Center, Texas College of Osteopathic Medicine

164 brown medical school department of medicine

INTERNATIONAL HEALTH AT BROWN OVERVIEW

hroughout the Brown community, there is great expertise as well as palpable enthusiasm for Tinternational health. Opportunities range from working with individual physicians who serve in a direct care capacity, taking part in formal medical exchange program, or participating in developed research projects within established international collaborations. The options for international electives at Brown are numerous and diverse with opportunities for many residents to participate.

MAJOR EXCHANGE PROGRAMS I Moi University Faculty of Health Sciences I Eldoret, Kenya I Hospital Cabral y Baez I Santiago, Dominican Republic EDUCATION

I YRG Care Formal medical education exchange programs I Chennai, India (presently both in Kenya and the Dominican Republic), I Sihanouk Hospital Center of Hope and Angkor are designed to improve education and patient care in Hospital for Children Phonm Penh and Siem Riep, Brown’s hospitals and in the host country’s hospitals Cambodia through long-term, mutual collaboration. Rotations are bi-directional: foreign students learn OTHER RELATIONSHIPS and teach on Miriam and Rhode Island Hospital I China wards while Brown residents and students do the same I Philippines abroad. Through these experiences, young physicians I Indonesia are exposed to a different spectrum of diseases and approaches to care. For example, a Brown resident I South Africa may return with an understanding of malaria’s impact I Jordan in the developing world while a Kenyan student I Ghana returns to her country with an understanding of the impact of cardiovascular disease in Rhode Island.

165 international health at brown

An infectious disease professor at Brown lectures during Grand Rounds at Moi University Hospital in Kenya.

RESEARCH FACULTY

Brown researchers are presently working in a variety Faculty members from througout the department are of countries (India, Cambodia, Philippines, and integral in international work. Their interests span Ghana, among others) in fields ranging from many countries and many disciplines, including infec- tuberculosis to women’s health to HIV prevention. tious disease, nephrology, pulmonary, and endocrinolo- gy. The faculty members involved have diverse responsibilities ranging from education to clinical care CLINICAL CARE activities to extensive research projects. They have had Collaborations are grounded in the desire to provide lasting effects both on the education of students and quality health care throughout the world, to alleviate residents and on public health internationally. The pain and suffering wherever it exists, and to address international influence of the Department of Medicine service inequities that contribute to poor health. All continues to grow in both scope and research funding. Brown educational programs share the belief that knowledge and its exchange are the keys to these goals. International health participants leave Brown with a sense of their role in the global community.

A Brown resident helps two Kenyan medical students perform a lumbar puncture on A patient on a hospital ward in the Dominican Republic a patient in sleeps under mosquito netting to protect the other patients Eldoret, Kenya. from mosquito-borne illnesses. 166 grand rounds

MEDICAL GRAND ROUNDS

“Academia, Primary Care, and the Chronically Ill” Edward H. Wagner, M.D., MPH, FACP, Director, W.A. MacColl Institute for Healthcare Innovation, Group Health Cooperative of Puget Sound, Adjunct Professor, University of North Carolina at Chapel Hill School of Public Health, Department of Epidemiology, Professor, University of Washington, School of Public Health and Community Medicine, Department of Health Services

JULY, 2003 – JUNE, 2005

July 1, 2003 Geriatrics Update – “Chronic Dizziness in Older Persons”, Aman Nanda, M.D., Assistant Professor of Medicine, Brown Medical School “Delirium: An Opportunity to Improve the Care of Hospitalized Older Persons”, Lynn McNicoll, M.D., FRCPC, Assistant Professor of Medicine, Brown Medical School July 8, 2003 Critical Care Update – “New Definitions of Sepsis”, Mitchell M. Levy, M.D., FCCM, FCCP, Associate Professor of Medicine, Brown Medical School “Transfusion Therapy in the ICU”, Nicholas S. Ward, M.D., FCCP, Assistant Professor of Medicine, Brown Medical School July 15, 2003 “The Challenge of Islet Transplantation”, Gordon C. Weir, M.D., Professor of Medicine, Harvard Medical School

167 grand rounds

July 22, 2003 “New Concepts in Hepatitis B & C, and Chronic Liver Disease”, Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg - Artemis and Martha Joukowsky Professor in Gastroenterology and Professor of Medical Science, Brown Medical School; Kittichai Promrat, M.D., Assistant Professor of Medicine, Brown Medical School July 29, 2003 Morbidity & Mortality Conference – Case 1: “A 32-year-old female presenting with chest pain”, Lina Nemchenok, M.D., Clinical Instructor of Medicine, Brown Medical School; Raymond Powrie, M.D., Associate Professor of Medicine, Brown Medical School; Marilyn Weigner, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Marc Shapiro, M.D., Assistant Professor of Emergency Medicine, Brown Medical School Case 2: “An 83-year-old man with a one month history of fatigue and headache”, Jeffrey Austerlitz, M.D., Clinical Instructor of Medicine, Brown Medical School; Timothy P. Flanigan, M.D., Associate Professor of Medicine, Brown Medical School; James Butera, M.D., Clinical Assistant Professor of Medicine, Brown Medical School September 9, 2003 Morbidity & Mortality Conference – Case 1: “A 60-year-old female presenting with SOB and a fulmi- nant pneumonia”, Tony Wu, M.D., Clinical Instructor of Medicine, Brown Medical School; Sidney S. Braman, M.D., FACP,FCCP,Professor of Medicine, Brown Medical School; Leonard Mermel, D.O., ScM, AM (Hon), FACP,FIDSA, Associate Professor of Medicine, Brown Medical School Case 2: “A 45-year-old woman with acute chronic abdominal pain and a 30 lb. weight loss”, Sajeev Handa, M.D., Clinical Instructor of Medicine, Brown Medical School; Victor Pricolo, M.D., Professor of Surgery, Brown Medical School; Brian Murphy, M.D., Assistant Professor (Clinical) of Diagnostic Imaging, Brown Medical School; Harlan Rich, M.D., Associate Professor of Medicine, Brown Medical School September 16, 2003 “Idiopathic Interstitial Pneumonias: What are they and why you should care”, Fernando J. Martinez, M.D., MS, Professor of Medicine, University of Michigan Medical Center September 23, 2003 “Heparin-induced Thrombocytopenia: Diagnosis and Management”, Theodore E. Warkentin, M.D., FRCP(C), FACP, Professor of Pathology and Molecular Medicine, McMaster University September 30, 2003 “Management of a Young Man with Pneumonia and Hypotension: Lessons Learned”, David L. Coleman, M.D., Professor of Medicine, Yale School of Medicine October 7, 2003 Morbidity & Mortality Conference – Case 1: “A 72-year-old male presenting with worsening SOB”, Dominick Tammaro, M.D., Associate Professor of Medicine, Brown Medical School; Walter Donat, M.D., Clinical Associate Professor of Medicine, Brown Medical School; John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School; Walter Biffl, M.D., Associate Professor of Surgery, Brown Medical School Case 2: “A 63-year-old man presents with ascites and abdominal pain”, Anne Moulton, M.D., Associate Professor of Medicine, Brown Medical School; John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School; Harlan Rich, M.D., Associate Professor of Medicine, Brown Medical School October 14, 2004 Dermatology Update – “The Safe and Effective Use of Immunomodulatory and Cytotoxic Drugs in Dermatological Diseases”, Charles J. McDonald, M.D., Professor of Medical Science, Department of Dermatology, Brown Medical School “Skin Cancer in the Post Transplant Population: Management and the Role of Retinoid Chemoprevention”, John J. DiGiovanna, M.D., Professor of Dermatology, Brown Medical School October 21, 2003 “Medical Malpractice: the defense attorney’s perspective”, David W. Carroll, Esq., Attorney with Providence law firm of Roberts, Carroll, Feldstein & Peirce, Inc. October 28, 2003 The Galkin Lecture – “Overcoming Obstacles to HIV Treatment in Resource-Poor Settings: The HIV Equity Initiative in Haiti”, Paul E. Farmer, M.D., Ph.D., Maude and Lillian Presley Professor of Medical Anthropology in the Department of Social Medicine, Harvard Medical School

168 grand rounds

November 4, 2003 Morbidity & Mortality Conference – Case 1: “A 70-year-old Portuguese male with HA, fatigue, and hemoptysis”, Cara McLaughlin, M.D., House Staff Officer, Brown Medical School; Kevin Dushay, M.D., Assistant Professor of Medicine, Brown Medical School; Stuart Schwartz, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Christopher Cosgrove, M.D., Clinical Instructor of Medicine, Brown Medical School Case 2: “A 34-year-old female with HIV/AIDS and cardiomyopathy presents with left-sided weakness”, Mark Fagan, M.D., Associate Professor of Medicine, Brown Medical School; Andreas Schoeck, M.D., Clinical Neurophysiology, Brown Medical School; Katharine Stansmore, M.D., Clinical Instructor of Medicine, Brown Medical School; Jennifer Mitty, M.D., MPH, Assistant Professor of Medicine, Brown Medical School November 11, 2003 Renal Update – “Renal Artery Stenosis”, Lance D. Dworkin, M.D., Professor of Medicine, Brown Medical School “Current Therapy of Hypertension”, Douglas Shemin, M.D., Clinical Associate Professor of Medicine, Brown Medical School “Resistant Hypertension”, Angelito F. Yango, Jr., M.D., Assistant Clinical Professor of Medicine, Brown Medical School November 18, 2003 “Current Understanding of Hereditary Hemorrhagic Telangiectasia”, Daniel M. Goodenberger, M.D., Professor of Medicine, Washington University School of Medicine November 25, 2003 “The Nature of Suffering and Nature of Opportunity at the End of Life”, Ira R. Byock, M.D., Research Professor, Department of Philosophy, University of Montana December 2, 2003 Morbidity & Mortality Conference – Case 1: “A 53-year-old man with fever, cough, and pleuritic pain who developed severe respiratory distress and multi-organ failure”, Kevin Dushay, M.D., Assistant Professor of Medicine, Brown Medical School; James Butera, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Harlan Rich, M.D., Associate Professor of Medicine, Brown Medical School; Mark LeGolvan, M.D., House Staff Officer, Brown Medical School Case 2: “A 31-year-old woman with severe, rapidly progressive dyspnea during the second trimester of pregnancy”, Athena Poppas, M.D., Assistant Professor of Medicine, Brown Medical School; James Klinger, M.D., Associate Professor of Medicine, Brown Medical School; Margaret Miller, M.D., Assistant Professor of Medicine, Brown Medical School December 9, 2003 Radiology Update – “Radiofrequency Ablation (RFA)”, Damian E. Dupuy, M.D., Associate Professor of Diagnostic Imaging, Brown Medical School “PET Scanning”, Richard B. Noto, M.D., Assistant Professor (Clinical) of Diagnostic Imaging, Brown Medical School “Treatment of Varicosities”, Gregory M. Soares, M.D., Assistant Professor of Diagnostic Imaging, Brown Medical School December 16, 2003 The Kameny Lecture – “Delirium: Pearls for Practice”, Sharon K. Inouye, M.D., M.P.H., Professor of Medicine, Yale University School of Medicine January 6, 2004 “Influenza in 2004!”, Timothy P. Flanigan, M.D., Associate Professor of Medicine, Brown Medical School January 13, 2004 “Cardiovascular MRI: The Future is Now”, Michael K. Atalay, M.D., Ph.D., Assistant Professor of Diagnostic Imaging, Brown Medical School January 20, 2004 “Cancer Gene Therapy with Designer T Cells: A Model for Translational Research in Immuno- Oncology”, Richard P. Junghans, Ph.D., M.D., Assistant Professor (adjunct), Program in Bioengineering, Boston University School of Engineering

169 grand rounds

January 27, 2004 Morbidity & Mortality Conference – Case 1: “An 83-year-old male with fever, headache, and mental status changes”, Mitchell Levy, M.D., FCCM, FCCP,Associate Professor of Medicine, Brown Medical School; Andrew Sucov, M.D., Assistant Professor of Community Health, Brown Medical School; Staci Fischer, M.D., Assistant Professor of Medicine, Brown Medical School Case 2: “A 61-year-old woman with lung cancer and recurrent thrombotic episodes”, Sajeev Handa, M.D., Clinical Instructor of Medicine, Brown Medical School; Anita Kestin, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Edward Donnelly, M.D., Assistant Professor (Clinical) of Clinical Neuroscience, Brown Medical School February 3, 2004 Morbidity & Mortality Conference – Case 1: “A 55-year-old man with a history of inflammatory bowel disease and progressive shortness of breath”, Lynn Bowlby, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; Walter Thayer, Jr., M.D., Professor Emeritus, Department of Medicine, Brown Medical School; Kevin Dushay, M.D., Assistant Professor of Medicine, Brown Medical School; Howard Safran, M.D., Associate Professor of Medicine, Brown Medical School Case 2: “A 37-year-old woman with abdominal pain and distention”, Tara Lagu, M.D., House Staff Officer, Brown Medical School; James Butera, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Douglas Shemin, M.D., Associate Professor of Medicine, Brown Medical School February 10, 2004 Pulmonary Update – “GOLD Guidelines”, Sidney S. Braman, M.D., FACP, FCCP, Professor of Medicine, Brown Medical School “Update on Lung Volume Reduction Surgery”, Kevin M. Dushay, M.D., Assistant Professor of Medicine, Brown Medical School February 24, 2004 “Osteoporosis: you can have an impact in 2004”, Meryl S. LeBoff, M.D., Associate Professor of Medicine, Harvard Medical School March 2, 2004 Morbidity & Mortality Conference – Case 1: “A 39-year-old woman with agitation and hal- lucinations”, Jennifer Hur, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; Rendueles Villalba, M.D., Clinical Assistant Professor of Psychiatry, Brown Medical School; James Gilchrist, M.D., Professor of Clinical Neuroscience, Brown Medical School Case 2: “A 79-year-old woman with SOB”, Anita Kestin, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; James Butera, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; John Murphy, M.D., Professor of Medicine, Brown Medical School March 9, 2004 Hematology/Oncology Update – “Reducing the Lung Cancer Mortality Epidemic: Screening and Adjuvant Chemotherapy”, Gary M. Strauss, M.D., MPH, Associate Professor of Medicine (pending), Brown Medical School March 16, 2004 “New Developments in the Treatment of Colorectal Cancer”, Edith P. Mitchell, M.D., FACP, Clinical Professor of Medicine, Jefferson Medical College March 23, 2004 “Practice Guidelines for the Management of Bacterial Meningitis”, Allan R. Tunkel, M.D., Ph.D., Professor of Medicine, Drexel University College of Medicine March 30, 2004 “Occupational Transmission of HIV, Hepatitis B & C, and Prevention”, Timothy P. Flanigan, M.D., Associate Professor of Medicine, Brown Medical School April 6, 2004 Morbidity & Mortality Conference – Case 1: “A 57-year-old man with weakness, confusion and fever”, Tony Wu, M.D., Clinical Instructor of Medicine, Brown Medical School; Stuart Schwartz, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Josiah Rich, M.D., Associate Professor of Medicine, Brown Medical School; Gary M. Strauss, M.D., MPH, Associate Professor of Medicine (pending), Brown Medical School Case 2: “A 23-year-old woman at 12 weeks gestation with fever, abdominal pain, and hypotension”, Nicholas Ward, M.D., FCCP,Assistant Professor of Medicine, Brown Medical School; John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School; Raymond Powrie, M.D., 170 Associate Professor of Medicine, Brown Medical School grand rounds

April 13, 2004 “Infectious Risks of Blood Transfusion”, Edward L. Snyder, M.D., FACP, Professor of Laboratory Medicine, Yale University School of Medicine April 20, 2004 Radiology Update – “Abdominal Imaging: Which test is best?!”, John J. Cronan, M.D., FACR, Professor of Diagnostic Imaging, Brown Medical School April 27, 2004 “Prevention of Sudden Cardiac Death – What Have Recent Clinical Trials Taught Us?”, Alfred E. Buxton, M.D., Professor of Medicine, Brown Medical School May 4, 2004 Morbidity & Mortality Conference – Case 1: “A 28-year-old man with persistent fever and odynophagia”, Laurel A. Bliss, M.D., House Staff Officer, Brown Medical School; Staci Fischer, M.D., Assistant Professor of Medicine, Brown Medical School Case 2: “A 48-year-old man with mental status changes, hypothermia, and acute renal failure”, Christopher Cosgrove, M.D., Clinical Instructor of Medicine, Brown Medical School; John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School; Philip Stockwell, M.D., Clinical Assistant Professor of Medicine, Brown Medical School May 11, 2004 Endocrine Update – “Is the Combination of Thyroxine and Triiodothyronine Better Than T4 Alone for Hypothyroidism?”, James V. Hennessey, M.D., Associate Professor of Medicine, Brown Medical School “Insulin: Yesterday, Today and Tomorrow”, Marc Laufgraben, M.D., Clinical Assistant Professor of Medicine, Brown Medical School May 18, 2004 “Gynecomastia”, Glenn D. Braunstein, M.D., Professor of Medicine, David Geffen School of Medicine at UCLA May 25, 2004 The Grace McLeod Rego Memorial Lecture – “Medical Professionalism and the Generation Gap”, Lawrence G. Smith, M.D., Horace W. Goldsmith Professor of Medicine, Mount Sinai School of Medicine June 8, 2004 “Chronic Kidney Disease: A High Risk Population for Cardiovascular Disease”, Charles A. Herzog, M.D., Professor of Medicine, University of Minnesota June 15, 2004 Rheumatology Update – “Use of ANCA Testing in the Diagnosis and Treatment of Vasculitis”, Stuart Schwartz, M.D., Clinical Assistant Professor of Medicine, Brown Medical School “Anticitrulline Antibodies”, David Kadmon, M.D., Clinical Assistant Professor of Medicine, Boston University School of Medicine June 22, 2004 Morbidity & Mortality Conference – Case 1: “A 73-year-old man with hypercalcemia”, Jennifer Jeremiah, M.D., Clinical Associate Professor of Medicine, Brown Medical School; Jack Monchik, M.D., Clinical Professor of Surgery, Brown Medical School; Howard Safran, M.D., Associate Professor of Medicine, Brown Medical School; Gregory Soares, M.D., Assistant Professor of Diagnostic Imaging, Brown Medical School Case 2: “A 51-year-old man with nausea, vomiting, and SOB”, Michael Stanchina, M.D. Assistant Professor of Medicine, Brown Medical School; Walter Biffl, M.D., Associate Professor of Surgery, Brown Medical School; Christopher Cosgrove, M.D., Clinical Instructor of Medicine, Brown Medical School; Thomas Bledsoe, M.D., Clinical Associate Professor of Medicine, Brown Medical School June 29, 2004 “Dilemmas in Cerebrovascular Disease”, J. Donald Easton, M.D., Professor of Clinical Neuroscience, Brown Medical School; Edward Feldmann, M.D., Professor of Clinical Neuroscience, Brown Medical School July 13, 2004 “Chronic Sinusitis: ‘Asthma’ of the Upper Airway”,Larry Borish, M.D., Professor of Medicine, University of Virginia Health System July 20, 2004 Cardiology Update – “Management of patients with ventricular ectopy and nonsustained ven- tricular tachycardia”, Alfred E. Buxton, M.D., Professor of Medicine, Brown Medical School “Prognosis and follow-up of LBBB in a patient with normal ventricular function”, Kristin E. Ellison, M.D., Assistant Professor of Medicine, Brown Medical School 171 grand rounds

“What needs to be done for the patient with asymptomatic ventricular pre-excitation?”, Malcolm M. Kirk, M.D., Assistant Professor of Medicine, Brown Medical School July 27, 2004 Morbidity & Mortality Conference – Case 1: “A 78-year-old female with enterococcus faecalis endocarditis”, Sajeev Handa, M.D., Clinical Instructor of Medicine, Brown Medical School; Leonard Mermel, D.O., ScM, AM (Hon), FACP, FIDSA, Associate Professor of Medicine, Brown Medical School Case 2: “An 84-year-old man with mental status change and an osmolar gap”, Michelle Stozek, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; James Klinger, M.D., Associate Professor of Medicine, Brown Medical School; Douglas Shemin, M.D., Associate Clinical Professor of Medicine, Brown Medical School September 14, 2004 Morbidity & Mortality Conference – Case 1: “A 67-year-old asplenic female with fatigue and jaundice”, David Dosa, M.D., Assistant Professor of Medicine, Brown Medical School; Staci Fischer, M.D., Assistant Professor of Medicine, Brown Medical School; Joseph Sweeney, M.D., Professor of Pathology and Laboratory Medicine, Brown Medical School Case 2: “A 20-year-old male with weakness”, Michael Maher, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; Dominic Corrigan, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; John O’Bell, M.D., Assistant Professor of Medicine, Brown Medical School September 21, 2004 “Antibiotic Resistance: Why You Should Care and What You Should Do”, Robert A. Weinstein, M.D., Professor of Medicine, Rush Medical College September 28, 2004 “Update on Influenza”, John B. Murphy, M.D., Professor of Medicine and Family Medicine, Brown Medical School October 5, 2004 “Patients with Alcohol Problems”, Patrick G. O’Connor, M.D., MPH, Professor of Medicine, Yale University School of Medicine October 12, 2004 “Continuous Positive Airway Pressure Therapy for Sleep Apnoea”, Walter McNicholas, M.D., Newman Clinical Research Professor, University College Dublin, Ireland October 19, 2004 Morbidity & Mortality Conference – Case 1: “A 57-year-old female with lower extremity weakness”, Christine Duffy, M.D., Assistant Professor of Medicine, Brown Medical School; Joseph Harwell, M.D., Assistant Professor of Medicine, Brown Medical School; Charlene Tate, M.D., Assistant Professor (Clinical) of Clinical Neuroscience; Mark Palumbo, M.D., Assistant Professor of Orthopaedics, Brown Medical School Case 2: “A 26-year-old male with confusion and a testicular mass”, Michael Stanchina, M.D., Assistant Professor of Medicine, Brown Medical School; Joseph Harwell, M.D., Assistant Professor of Medicine, Brown Medical School; Lance D. Dworkin, M.D., Professor of Medicine, Brown Medical School; J. Dawn Abbott, M.D., FACC, Assistant Professor of Medicine, Brown Medical School; Arthur Wong, M.D., Clinical Instructor of Surgery, Brown Medical School October 26, 2004 Nephrology Update – “Current Approaches to Proteinuria and Diabetic Nephropathy”, Susie Lee Hu, M.D., Assistant Professor of Medicine, Brown Medical School; John O’Bell, M.D., Assistant Professor of Medicine, Brown Medical School November 9, 2004 The Kameny Lecture – “Transitional Care: The Next Frontier for Quality Improvement”, Eric A. Coleman, M.D., MPH, Associate Professor of Medicine with Tenure, University of Colorado Health Sciences Center November 16, 2004 “New Ideas for Old Hearts – Molecular Aspects of Heart Disease in Seniors”, Jeanne Y. Wei, M.D., Ph.D., Professor of Physiology and Biophysics, University of Arkansas for Medical Sciences November 23, 2004 Update on the Endocrinology of Critical Illness – “Thyroid, Gonadal, and Growth Hormone Axes in Critical Illness”, James V. Hennessey, M.D., Associate Professor of Medicine, Brown Medical School

172 grand rounds

“The Gray Zone of Glucocorticoid Insufficiency in Critical Illness”, Dominic Corrigan, M.D., Clinical Assistant Professor of Medicine, Brown Medical School November 30, 2004 “Viral Carcinogenesis and High Risk HPV in Appalachia”, Eddie Reed, M.D., Professor, Department of Internal Medicine, Department of Microbiology, Immunology and Cell Biology, School of Medicine, Robert C. Byrd Health Sciences Center, West Virginia University December 7, 2004 Morbidity & Mortality Conference – “Three Cases of PE”, Nicholas Ward, M.D., FCCP, Assistant Professor of Medicine, Brown Medical School; Mitchell Levy, M.D., FCCM, FCCP, Associate Professor of Medicine, Brown Medical School; James Klinger, M.D., Associate Professor of Medicine, Brown Medical School; Athena Poppas, M.D., Assistant Professor of Medicine, Brown Medical School December 14, 2004 “Advances in Prostate Cancer”, William K. Oh, M.D., Assistant Professor of Medicine, Harvard Medical School December 21, 2004 Gastroenterology Update – “Did capsule endoscopy establish its role in GI?”, Ramy Eid, M.D., Assistant Professor of Medicine, Brown Medical School “Liver disease and the obesity epidemic”, Pierre Gholam, M.D., Assistant Professor of Medicine, Brown Medical School January 4, 2005 “Pandemic Influenza: A Story of Birds, Pigs and Humans”, Leonard A. Mermel, D.O., ScM, AM (Hon), FACP, FIDSA, Associate Professor of Medicine, Brown Medical School January 11, 2005 Morbidity & Mortality Conference – Case 1: “A brother and sister with AML”, James Butera, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Anthony Mega, M.D., Assistant Professor of Medicine, Brown Medical School; Peter Quesenberry, M.D., Professor of Medicine, Boston University School of Medicine Case 2: “A chronic undiagnosed pleural effusion”, Tony Wu, M.D., Clinical Instructor of Medicine, Brown Medical School; Kevin Dushay, M.D., Assistant Professor of Medicine, Brown Medical School; Sripathi Kethu, M.D., Assistant Professor of Medicine, Brown Medical School January 18, 2005 “Tobacco Treatment Works! Essential Components for Quit Success”, Patricia A. Nolan, M.D., MPH, Clinical Assistant Professor of Community Health, Brown Medical School; Sharon L. Marable, M.D., MPH, Clinical Assistant Professor of Community Health, Brown Medical School January 25, 2005 “Kenya, The Dominican Republic, and Others: The International Experience of the Brown Department of Medicine”, Edward J. Wing, M.D., Joukowsky Family Professor of Medicine, Brown Medical School February 1, 2005 Morbidity & Mortality Conference – Case 1: “A 70-year-old woman with sudden onset of chest pain”, Dominick Tammaro, M.D., Associate Professor of Medicine, Brown Medical School; George McKendall, M.D., Associate Professor of Medicine, Brown Medical School; Steven Moss, M.D., Associate Professor of Medicine, Brown Medical School; Timothy P. Flanigan, M.D., Professor of Medicine, Brown Medical School Case 2: “An 84-year-old man with complications from a chronic empyema”, Jennifer Hur, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; William Feng, M.D., Associate Clinical Professor of Surgery, Brown Medical School; Muhanned Abu-Hijleh, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Thomas Bledsoe, M.D., Clinical Associate Professor of Medicine, Brown Medical School February 8, 2005 Cardiology Update – “Non-Pharmacological Treatment for Atrial Fibrillation”, Ian Woollett, M.D., Assistant Professor of Medicine, Brown Medical School “Overview of BiVentricular Pacing with discussion of expanded indications and patient follow-up”, Kristin E. Ellison, M.D., Assistant Professor of Medicine, Brown Medical School

173 grand rounds

“Congestive Heart Failure Strategies 2005”, Daniel J. Levine, M.D., Clinical Assistant Professor of Medicine, Brown Medical School February 15, 2005 Hematology/Oncology Update – “The Expanding Role of Hormonal Therapy for Prostate Cancer”, Anthony Mega, M.D., Assistant Professor of Medicine, Brown Medical School “Recent Advances in Breast Cancer for the Non-Oncologist”, William Sikov, M.D., Clinical Assistant Professor of Medicine, Brown Medical School March 1, 2005 “Asthma: A Disease of Irreversible Airway Obstruction”, Reynold A. Panettieri, Jr., M.D., Robert L. Mayock and David A. Cooper Professor of Medicine with Tenure, University of Pennsylvania School of Medicine March 8, 2005 General Internal Medicine Update – “Is Treating Chronic Pain Torture? A Survey of Brown Internal Medicine Residents”, Mark J. Fagan, M.D., Associate Professor of Medicine, Brown Medical School “Antiplatelet Therapy: Which Drugs for Which Patients?”, Mark D. Schleinitz, M.D., MS, Assistant Professor of Medicine, Brown Medical School “Patient-Centered Informatics: Enhancing Patients’ Role in Decision-Making and Leveraging Physicians’ Time”, Nananda F. Col, M.D., MPP, MPH, FACP, Associate Professor of Medicine, Brown Medical School March 15, 2005 “Claudication: Diagnosis and Management”, Moderator: David O. Williams, M.D., Professor of Medicine, Brown Medical School; “Detection and Medical Treatment”, J. Dawn Abbott, M.D., FACC, Assistant Professor of Medicine, Brown Medical School; “Percutaneous Interventional Therapy”,Barry L. Sharaf, M.D., Associate Professor of Medicine, Brown Medical School; “Surgical Therapy for Claudication”, Edward J. Marcaccio, Jr., M.D., Assistant Professor of Surgery (Clinical), Brown Medical School March 22, 2005 Morbidity & Mortality Conference – “A 21-year-old Mexican man with diffuse weakness for several weeks”, Traci Tupper, M.D., House Staff Officer, Brown Medical School; Staci Fischer, M.D., Assistant Professor of Medicine, Brown Medical School; Syed Rizvi, M.D., Assistant Professor of Clinical Neuroscience, Brown Medical School March 29, 2005 “Venous Thromboembolism: A Decade of Progress”, Victor F. Tapson, M.D., Professor of Medicine, Duke University Medical Center April 5, 2005 Morbidity & Mortality Conference – Case 1: “A 63-year-old male presenting with shortness of breath, hypotension, and thrombocytopenia”, Elaine Pelley, Teaching Fellow in Medicine, Brown Medical School; Anita Kestin, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Dominic Corrigan, M.D., Clinical Assistant Professor of Medicine, Brown Medical School Case 2: “A 58-year-old female presenting with shortness of breath, pleural nodules and a neck mass”, Mary Hohenhaus, M.D., Assistant Instructor of Medicine, Brown Medical School; Gary Strauss, M.D., MPH, Associate Professor of Medicine (pending), Brown Medical School; James Klinger, M.D., Associate Professor of Medicine, Brown Medical School April 12, 2005 Infectious Diseases Update – “Current Management of Severe Sepsis and Septic Shock”, Steven P. LaRosa, M.D., Assistant Professor of Medicine, Brown Medical School “Controversies and Updates in the Treatment of Lyme Disease”, Jennifer A. Mitty, M.D., MPH, Assistant Professor of Medicine, Brown Medical School April 19, 2005 “Improving Hand Hygiene in Healthcare Settings”, John M. Boyce, M.D., Clinical Professor of Medicine, Yale University School of Medicine April 26, 2005 The Beckwith Family Visiting Professorship in Medicine – “Male Menopause: Myth, Menace of Misnomer”, Marc R. Blackman, M.D., Professor of Medicine (part-time), The Johns Hopkins University School of Midicine

174 grand rounds

May 3, 2005 Rheumatology Update – “Systemic Lupus Erithematosus: Recent Insights into Pathogenesis, Clinical Subsets and Treatment Strategies”, Edward V. Lally, M.D., Associate Professor of Medicine, Brown Medical School May 10, 2005 Morbidity & Mortality Conference – Case 1: “A 42-year-old woman with HIV/AIDS presenting with shortness of breath and anemia”, Iris Tong, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; Mary Anne Fenton, M.D., Clinical Instructor of Medicine, Brown Medical School; Michael Stein, M.D., Professor of Medicine, Brown Medical School Case 2: “A73-year-old male with chronic lung disease presenting with hypoxia and a pleural effusion”, Anne Moulton, M.D., Associate Professor of Medicine, Brown Medical School; Muhanned Abu-Hijleh, M.D., Clinical Assistant Professor of Medicine, Brown Medical School May 17, 2005 “NSAIDs and Coxibs: The Good, the Bad, and the Ugly”, Victor L. Schuster, M.D., Baumritter Professor of Medicine, Albert Einstein College of Medicine May 24, 2005 The Grace McLeod Rego Memorial Lecture – “Renewal in the Practice of Medicine”, Charles J. Hatem, M.D., The Harold Amos Academy Professor, Professor of Medicine, Harvard Medical School June 7, 2005 “Emerging Tick-borne Zoonoses: Lyme Disease, Babesiosis and HGE”, Peter J. Krause, M.D., Professor of Pediatrics, University of Connecticut School of Medicine June 14, 2005 “New Research Findings on the Treatment and Management of Depression”, Mark Zimmerman, M.D., Associate Professor in Psychiatry and Human Behavior, Brown Medical School June 21, 2005 Morbidity & Mortality Conference – Case 1: “A 35-year-old woman with headache and fever”, Michael Maher, M.D., Assistant Professor (Clinical) of Medicine, Brown Medical School; Timothy P. Flanigan, M.D., Professor of Medicine, Brown Medical School Case 2: “A 23-year-old woman with fever and positive blood cultures”, Kelly McGarry, M.D., Assistant Professor of Medicine, Brown Medical School; James Arrighi, M.D., Associate Professor of Medicine, Brown Medical School; John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School June 28, 2005 Pulmonary Update – “Interventional Pulmonology: New Developments”, Sidney S. Braman, M.D., FACP, FCCP, Professor of Medicine, Brown Medical School; Muhanned A. Abu-Hijleh, M.D., Clinical Assistant Professor of Medicine, Brown Medical School

Drs. Ted Sears and Nicole Theodoropoulos at Noon Conference.

Preceptors and residents discuss their ambulatory patients in the Rhode Island Hospital Medical Primary Care Unit (MPCU)

175 clinical activity

CLINICAL ACTIVITY FIVE YEAR PERIOD INCLUDING: FY 1999, FY 2000, FY 2001, FY 2002, FY 2003 AND FY 2004

Rhode Island Hospital

FY 99 FY 00 FY 01 FY 02 FY 03 FY 04 10/98-9/99 0/99-9/00 10/00-9/01 10/01-9/02 10/02-9/03 0/03-9/04

Inpatient 12700 11647 11909 13477 12725 12983 Admissions/Discharges

Outpatient Volume 122296 126846 142861 132793 133302 145259

The Miriam Hospital

FY 99 FY 00 FY 01 FY 02 FY 03 FY 04 10/98-9/99 10/99-9/00 10/00-9/01 10/01-9/02 10/02-9/03 10/03-9/04

Inpatient 7604 7532 8219 8273 8383 9004 Admissions/Discharges

Outpatient Volume 42124 37009 43504 81775 95297 121184

Memorial Hospital of Rhode Island

FY 99 FY 00 FY 01 FY 02 FY 03 FY 04 10/98-9/99 10/99-9/00 10/00-9/01 10/01-9/02 10/02-9/03 10/03-9/04

Inpatient 7617 7896 7560 7698 7703 7888 Admissions/Discharges

Outpatient Volume 22125 26277 26740 41197 40,314 42,633

Providence Veterans Administration Medical Center

FY 99 FY 00 FY 01 FY 02 FY 03 FY 04 10/98-9/99 10/99-9/00 10/00-9/01 10/01-9/02 10/02-9/03 10/03-9/04

Admissions 1836 1809 1642 1779 1988 2674

Discharges 1750 1718 1558 1698 1899 2650

Ambulatory Visits 77800 81532 85292 92681 93602 97653

176 research activity

RESEARCH OVERVIEW

rown University has long been regarded as a Both basic and clinical research are well represented leader in all aspects of health care and teaching, in the Department. For basic research, major Bincluding research. In 1998, the recruitment of strengths include the Liver Research Center (directed Dr. Edward Wing as the Chief of Medicine signaled an by Dr. Jack Wands), Diabetes and Endocrinology acceleration of an already growing and expanding Research Center (directed by Dr. Robert Smith), and commitment to basic and clinical research within Medical Oncology, which among other research the Brown University Academic Medical Center grants also has a multi-million dollar COBRE grant Department of Medicine. Research funding within the from the National Institutes of Health for establishing Department of Medicine at Rhode Island Hospital, a Genomics and Proteomics Core laboratory and a Memorial Hospital of Rhode Island, Veterans Center for Cancer Research Development. Administration-Providence and The Miriam Hospital Clinical Research strengths include the Infectious grew from $9.9 million in 1997 to over $35.6 million in Disease program under Dr. Timothy Flanigan, which has 2004 – greater than a 250% increase over that period. a major program in both domestic and international Over 75% of current funding comes from federal HIV/AIDS (including a NIH funded Center for AIDS programs such as NIH, HRSA, CDC, and HHS. Research program, T-32 Training grant from NIH, and The major research laboratories, animal facilities and Fogarty International program), General Internal centers at Brown are located among all the affiliates Medicine Substance Abuse Research Unit, under Dr. with Rhode Island Hospital accounting for the Michael Stein, and the Cardiology research groups majority (59% of overall Department of Medicine under Dr. David Williams (Interventional Cardiology) funding). These laboratories are highlighted by the and Dr. Alfred Buxton (Electrophysiology). Galletti Research Building, a 60,000+ square foot With ongoing recruitments for both senior and junior research facility, which houses the Liver Research faculty, increasing successes of our existing faculty, Center, Diabetes Research Center, and Infectious research for the Department of Medicine should con- Disease laboratories. tinue to grow and become even stronger in the future.

RESEARCH GROWTH FY96–FY04 $40,000,000

$35,000,000 RIH $30,000,000 TMH $25,000,000 MEM

$20,000,000 VA

$15,000,000

$10,000,000

$5,000,000

$0 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 177 hen it comes to clinical experience, Brown Medical School Department of Medicine offers Wan enviable variety of sites. It is affiliated with five area hospitals - all within a fifteen-minute drive of the Brown campus - that serve one and a half million people of diverse backgrounds and socioeconomic status. The road to becoming a physician or scientist at Brown Medical School takes students to these hospitals as well as to countless other clinical sites, such as community practices throughout the state, inner city clinics, and biotech companies. These sites provide a range of diverse training opportunities for medical students and residents. The Medical School and its hospital partners are the anchors of Rhode Island’s academic medical center.

BROWN MEDICAL SCHOOL AFFILIATED HOSPITALS

RHODE ISLAND HOSPITAL Rhode Island Hospital, with 719 beds, is the state’s largest hospital and the third largest hospital in New England. It is designated as the Level 1 Trauma Center for southeastern New England, providing expert staff and equipment in emergency situations 24 hours a day. Rhode Island Hospital is home to a Comprehensive Cancer Center. Its pediatric division, Hasbro Children’s Hospital, opened in 1994 and cares for some 7,000 inpatients and 60,000 outpatients annually.

Rhode Island Hospital

THE MEMORIAL HOSPITAL OF RHODE ISLAND The Memorial Hospital of Rhode Island is a 294-bed hospital that serves a community of more than 180,000 people in Pawtucket and the Blackstone Valley region of Rhode Island. Memorial’s rehabilitation center focuses on services to patients afflicted by stroke, amputation, or neurological disability and includes comprehensive inpatient and outpatient services. The hospital offers cutting-edge cancer care and is the practice base for the Brown residency program in family medicine.

The Memorial Hospital of Rhode Island

178 THE MIRIAM HOSPITAL The Miriam Hospital is a 247-bed facility that provides a broad range of primary, secondary and tertiary medical and surgical services to adolescents and adults in 31 medical and surgical specialties and sub-specialties. Miriam Hospital is noted for its specialty services in AIDS at the Samuel and Esther Chester Immunology Center and in cardiac care. The Women’s Cardiac Center at The Miriam Hospital offers complete diagnostic and clinical cardiology services, cardiovascular surgery and cardiac rehabilitation to women. The Miriam Hospital

WOMEN & INFANTS HOSPITAL OF RHODE ISLAND Women & Infants’ Hospital of Rhode Island, which houses 137 single patient rooms and 120 infant bassinets, is one of the nation’s leading specialty hospitals for women and newborns. The primary teaching affiliate of Brown Medical School for obstetrics, gynecology and newborn pediatrics, Women & Infants is the tenth largest obstetrical service in the country with more than 9,700 deliveries per year. In 2003, Brown University and Women & Infants were named a National Center of Excellence in Women’s Health by the U.S. Women & Infants Hospital of Rhode Island Department of Health and Human Services. The hospital offers specialty gynecological services as well, for treatment of infertility and cancer, including the Breast Health Center, a specialized center offering education, support, diagnosis and contemporary treatment for all breast health problems.

THE VA MEDICAL CENTER The VA Medical Center is a 230-bed facility providing acute inpatient and ambulatory care in medicine, surgery, psychiatry and neurology. The hospital admits approximately 5,000 veterans annually and provides over 150,000 outpatient visits in 41 clinics. It is a regional center for treatment of post-traumatic stress disorder. The hospital also provides special medical services in the areas of dialysis, substance abuse treatment, rehabilitative medicine, and prosthetics.

The VA Medical Center

Brown Medical School is also affiliated with The Emma Pendelton Bradley Hospital and Butler Hospital, its associated psychiatric facilities. 179