DOCSLIB.ORG

Renato Dulbecco: Viruses, Genes, and Cancer

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Renato Dulbecco: Viruses, Genes, and Cancer RETROSPECTIVE Renato Dulbecco: Viruses, genes, and cancer Walter Eckhart1 Salk Institute for Biological Studies, La Jolla, CA 92037 enato Dulbecco, renowned virol- ogist and cancer researcher, R passed away peacefully at his home in La Jolla, CA, February 19, 2012, 3 days before his 98th birthday. He was celebrated not only for his scientific achievements but also for inspiring a gen- eration of younger scientists who went on to become distinguished in their own fields. Renato was a founding fellow of the Salk Institute, where he spent most of his career. He also served as president of the Institute from 1988 to 1992. Renato was born and educated in Italy. He received his MD degree from the University of Torino in 1936, after which he served in the Italian Army for 2 years. He returned to the University of Torino briefly before being drafted into the army again when the Second World War began. He was sent to the Russian front, where he was wounded. Following his recuperation, he joined the resistance, becoming a village physician near Torino. After the war ended, Renato decided to study physics at the urging of Rita Levi- Montalcini, who thought physics might be helpful in understanding genes. Two years later he met Salvador Luria, who invited him to join his laboratory at Indiana University. There he studied photoreacti- vation of bacteriophages (bacterial viruses) and became friends with Jim Watson (codiscoverer of the structure of DNA), who was a graduate student with Luria at the time. Following a summer at the Cold Spring Harbor Laboratory, he moved to the California Institute of Technology at the invitation of Max Delbrück. There he col- laborated with Marguerite Vogt to isolate pure strains and mutants of poliovirus using the plaque isolation technique that had been used so successfully for bacte- riophages. The techniques they developed made it possible to study the genetics of Renato Dulbecco. animal viruses in a quantitative way. Their collaboration continued after they joined the newly established Salk Institute 1975, together with David Baltimore and In 1972, Renato moved to England with in 1963, where they investigated mecha- Howard Temin, “for their discoveries his wife Maureen (who is Scottish) and nisms of cell transformation by tumor concerning the interaction between tumor their young daughter Fiona. He served viruses. I had the good fortune to be a viruses and the genetic material of as deputy director of research at the Im- postdoctoral fellow in Renato’s labora- the cell.” perial Cancer Research Fund Laboratories tory from 1965 to 1969, a particularly ex- Those who were fortunate to experience in London from 1972 to 1977. There- citing period. It was during that time that the camaraderie of Renato’s laboratory at after, he returned to the Salk Institute to he and his associates carried out the ex- the Salk Institute, which was enhanced by pursue a new interest in mammary cell periments showing that the DNA tumor the boundless enthusiasm of Marguerite biology and breast cancer, reflecting his virus SV40 became integrated into the Vogt, remember it fondly. There was a DNA of the host cell, a critical step in feeling of shared purpose, accompanied transforming the growth of the cell from by shared fun that was enviable. The Author contribution: W.E. wrote the paper. normal to malignant. He was awarded the freedom provided by the Salk Institute The author declares no conflict of interest. Nobel Prize for Physiology or Medicine in also played a part. 1E-mail: [email protected]. www.pnas.org/cgi/doi/10.1073/pnas.1203513109 PNAS | March 27, 2012 | vol. 109 | no. 13 | 4713–4714 Downloaded by guest on September 30, 2021 desire to apply insights from basic research sequence the human genome, described Project. During this period, he spent time to human health. in a letter to Science in 1986, with the both in Italy and at the Salk Institute. He Renato believed that science should be ultimate goal of deciphering the dif- finally returned permanently to La Jolla useful to mankind. In his Nobel lecture, he ferences in the cancer genome. Subse- and the Salk Institute in 2006. pointed out the potential dangers of sub- quent developments justified his optimistic Renato loved science, as great scientists stances in the environment—including predictions. do. He also loved music, and was an ac- many produced by human activity—that Renato was called upon to assume the complished pianist. He enjoyed working can cause mutations leading to cancer. He presidency of the Salk Institute in 1988 with his hands, and was fearless in attacking urged governments to discourage the following the illness of the previous pres- projects of homebuilding and renovation consumption of tobacco, a known carcin- ident, Frederic de Hoffmann. He accepted that would have daunted others. ogen. He also lamented the practical dif- the challenge and served with distinction in Renato was a stimulating mentor and ficulties in getting society to make the the position for 4 years. a generous colleague. He valued his required sacrifices. After his tenure as president of the Salk younger collaborators, for whom he Renato thought deeply about the Institute, Renato and Maureen returned was an inspiring role model. He was a implications of genetic discoveries for to Europe. Renato joined the Instituto true gentleman, conducting himself understanding cancer and human physi- di Tecnologie Biomediche Avanzate in with integrity and quiet confidence. His ology. These thoughts led him to sug- Milan to continue his work on breast spirit lives on in the memories of those gest an international undertaking to cancer and to direct the Italian Genome who knew him. 4714 | www.pnas.org/cgi/doi/10.1073/pnas.1203513109 Eckhart Downloaded by guest on September 30, 2021.
Load more

Recommended publications
  • 書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
    書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S.
    [Show full text]
  • Nobel Laureates Endorse Joe Biden
    Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S.
    [Show full text]
  • James D. Watson Molecular Biologist, Nobel Laureate ( 1928 – )
    James D. Watson Molecular biologist, Nobel Laureate ( 1928 – ) Watson is a molecular biologist, best known as one of the co-discoverers of the struc- ture of DNA. Watson, Francis Crick, and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine. Watson was born in Chicago, and early on showed his brilliance, appearing on Quiz Kids, a popular radio show that challenged precocious youngsters to answer ques- tions. Thanks to the liberal policy of University of Chicago president ROBERT HUTCHINS, Watson was able to enroll there at the age of 15, earning a B.S. in Zoology in 1947. He was attracted to the work of Salvador Luria, who eventually shared a Nobel Prize with Max Delbrück for their work on the nature of genetic mutations. In 1948, Watson began research in Luria’s laboratory and he received his Ph.D. in Zoology at Indiana University in 1950 at age 22. In 1951, the chemist Linus Pauling published his model of the protein alpha helix, find- ings that grew out of Pauling’s relentless efforts in X-ray crystallography and molecu- lar model building. Watson now wanted to learn to perform X-ray diffraction experi- ments so that he could work to determine the structure of DNA. Watson and Francis Crick proceeded to deduce the double helix structure of DNA, which they submitted to the journal Nature and was subsequently published on April 25, 1953. Watson subsequently presented a paper on the double helical structure of DNA at the Cold Spring Harbor Symposium on Viruses in early June 1953.
    [Show full text]
  • Jewels in the Crown
    Jewels in the crown CSHL’s 8 Nobel laureates Eight scientists who have worked at Cold Max Delbrück and Salvador Luria Spring Harbor Laboratory over its first 125 years have earned the ultimate Beginning in 1941, two scientists, both refugees of European honor, the Nobel Prize for Physiology fascism, began spending their summers doing research at Cold or Medicine. Some have been full- Spring Harbor. In this idyllic setting, the pair—who had full-time time faculty members; others came appointments elsewhere—explored the deep mystery of genetics to the Lab to do summer research by exploiting the simplicity of tiny viruses called bacteriophages, or a postdoctoral fellowship. Two, or phages, which infect bacteria. Max Delbrück and Salvador who performed experiments at Luria, original protagonists in what came to be called the Phage the Lab as part of the historic Group, were at the center of a movement whose members made Phage Group, later served as seminal discoveries that launched the revolutionary field of mo- Directors. lecular genetics. Their distinctive math- and physics-oriented ap- Peter Tarr proach to biology, partly a reflection of Delbrück’s physics train- ing, was propagated far and wide via the famous Phage Course that Delbrück first taught in 1945. The famous Luria-Delbrück experiment of 1943 showed that genetic mutations occur ran- domly in bacteria, not necessarily in response to selection. The pair also showed that resistance was a heritable trait in the tiny organisms. Delbrück and Luria, along with Alfred Hershey, were awarded a Nobel Prize in 1969 “for their discoveries concerning the replication mechanism and the genetic structure of viruses.” Barbara McClintock Alfred Hershey Today we know that “jumping genes”—transposable elements (TEs)—are littered everywhere, like so much Alfred Hershey first came to Cold Spring Harbor to participate in Phage Group wreckage, in the chromosomes of every organism.
    [Show full text]
  • Happy Birthday to Renato Dulbecco, Cancer Researcher Extraordinaire
    pbs.org http://www.pbs.org/newshour/updates/happy-birthday-renato-dulbecco-cancer-researcher-extraordinaire/ Happy birthday to Renato Dulbecco, cancer researcher extraordinaire Photo of Renato Dulbecco (public domain) Every elementary school student knows that Feb. 22 is George Washington’s birthday. Far fewer (if any) know that it is also the birthday of the Nobel Prize-winning scientist Renato Dulbecco. While not the father of his country — he was born in Italy and immigrated to the United States in 1947 — Renato Dulbecco is credited with playing a crucial role in our understanding of oncoviruses, a class of viruses that cause cancer when they infect animal cells. Dulbecco was born in Catanzaro, the capital of the Calabria region of Italy. Early in his childhood, after his father was drafted into the army during World War I, his family moved to northern Italy (first Cuneo, then Turin, and thence to Liguria). A bright boy, young Renato whizzed through high school and graduated in 1930 at the age of 16. From there, he attended the University of Turin, where he studied mathematics, physics, and ultimately medicine. Dulbecco found biology far more fascinating than the actual practice of medicine. As a result, he studied under the famed anatomist, Giuseppe Levi, and graduated at age 22 in 1936 at the top of his class with a degree in morbid anatomy and pathology (in essence, the study of disease). Soon after receiving his diploma, Dr. Dulbecco was inducted into the Italian army as a medical officer. Although he completed his military tour of duty by 1938, he was called back in 1940 when Italy entered World War II.
    [Show full text]
  • Renato Dulbecco
    BIOLOGIE ET HISTOIRE Renato Dulbecco Renato Dulbecco : de la virologie à la cancérologie F.N.R. RENAUD 1 résumé Né en Italie, Renato Dulbecco fait de brillantes études médicales mais est plus intéressé par la recherche en biologie que par la pratique médicale. Accueilli par Giuseppe Levi, il apprend l’histologie et la culture cellulaire avant de rejoindre le laboratoire de S.E. Luria puis celui de M. Delbrück pour travailler sur les systèmes bactéries-bactériophages puis sur la relation cellules-virus. Il met au point la méthode des plages de lyse virales sur des cultures cellulaires. Il est aussi à l’origine de la virologie tumorale moléculaire. D. Baltimore, HM Temin et lui-même sont récompensés par le prix Nobel de médecine et physiologie en 1975 pour leurs travaux sur l'interaction entre les virus tumoraux et le matériel génétique du matériel cellulaire. Très tourné vers les aspects pratiques et expérimentaux de la recherche, il est resté le plus long - temps possible à la paillasse et a initié un très grand nombre de jeunes chercheurs. mots-clés : culture cellulaire, virologie tumorale, plages de lyse, bactériophages. I. - LA JEUNESSE DE RENATO DULBECCO C'est à Catanzaro, capitale régionale de la Calabre en Italie, que naît Renato Dulbecco le 22 février 1914. Sa mère est Calabraise et son père Ligurien. Il ne reste que très peu de temps dans le sud de l’Italie, car son père est mobilisé et sa famille doit déménager dans le nord à Cuneo, puis à Turin. À la fin de la guerre, la famille Dulbeco s'ins - talle à Imperia en Ligurie.
    [Show full text]
  • The Eighth Day of Creation”: Looking Back Across 40 Years to the Birth of Molecular Biology and the Roots of Modern Cell Biology
    “The Eighth Day of Creation”: looking back across 40 years to the birth of molecular biology and the roots of modern cell biology Mark Peifer1 1 Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA * To whom correspondence should be addressed Email: [email protected] Phone: (919) 962-2272 1 Forty years ago, Horace Judson’s “The Eight Day of Creation” was published, a book vividly recounting the foundations of modern biology, the molecular biology revolution. This book inspired many in my generation. The anniversary provides a chance for a new generation to take a look back, to see how science has changed and hasn’t changed. Many central players in the book, including Sydney Brenner, Seymour Benzer and Francois Jacob, would go on to be among the founders of modern cell, developmental, and neurobiology. These players come alive via their own words, as complex individuals, both heroes and anti-heroes. The technologies and experimental approaches they pioneered, ranging from cell fractionation to immunoprecipitation to structural biology, and the multidisciplinary approaches they took continue to power and inspire our work today. In the process, Judson brings out of the shadows the central roles played by women in many of the era’s discoveries. He provides us with a vision of how science and scientists have changed, of how many things about our endeavor never change, and how some new ideas are perhaps not as new as we’d like to think. 2 In 1979 Horace Judson completed a ten-year project about cell and molecular biology’s foundations, unveiling “The Eighth Day of Creation”, a book I view as one of the most masterful evocations of a scientific revolution (Judson, 1979).
    [Show full text]
  • January 24, 2020 President Donald J. Trump the White House
    January 24, 2020 President Donald J. Trump The White House 1600 Pennsylvania Ave NW Washington, DC 20500 Dear President Trump: As 21 Nobel Prize award-winning scientists and scholars we are writing to express our strong support for immediate open access to the results of research funded with U.S. taxpayer dollars. We understand there is an Executive Order under consideration by your Administration that would remove the 12-month embargo currently in place for access to published, taxpayer-funded research and strongly urge you to sign this order. Immediate online access to the bounty of research funded and published with U.S. support is fundamental to realising the full potential of our nation’s $65b investment in science. We must ensure that human and machine readers alike have open access to the reports, data, and code stemming from our work in order that it may be built upon swiftly, efficiently, and be translated effectively into benefits for society. Such barriers must be removed. The work of our nation’s seven million scientists 1 is inhibited so long as there are delays before we are able to read the latest work in our fields. Improving public health through the investigation of new treatments and potential cures for disease is delayed. Growing the U.S. economy through the translation of research into new services, tools and businesses is delayed. Progress across all of our fields is delayed by the embargo on access. Immediate, open online access to U.S. research will create valuable visibility. We publish our findings so that they may be read and built upon.
    [Show full text]
  • Cover June 2011
    z NOBEL LAUREATES IN Qui DNA RESEARCH n u SANGRAM KESHARI LENKA & CHINMOYEE MAHARANA F 1. Who got the Nobel Prize in Physiology or Medicine 1933) for discovering the famous concept that says chromosomes carry genes? a. Gregor Johann Mendel b. Thomas Hunt Morgan c. Aristotle d. Charles Darwin 5. Name the Nobel laureate (1959) for his discovery of the mechanisms in the biological 2. The concept of Mutations synthesis of ribonucleic acid and are changes in genetic deoxyribonucleic acid? information” awarded him a. Arthur Kornberg b. Har Gobind Khorana the Nobel Prize in 1946: c. Roger D. Kornberg d. James D. Watson a. Hermann Muller b. M.F. Perutz c. James D. Watson 6. Discovery of the DNA double helix fetched them d. Har Gobind Khorana the Nobel Prize in Physiology or Medicine (1962). a. Francis Crick, James Watson, Rosalind Elsie Franklin b. Francis Crick, James Watson and Maurice Willkins c. James Watson, Maurice Willkins, Rosalind Elsie Franklin 3. Identify the discoverer and d. Maurice Willkins, Rosalind Elsie Franklin and Francis Crick Nobel laureate of 1958 who found DNA in bacteria and viruses. a. Louis Pasteur b. Alexander Fleming c. Joshua Lederberg d. Roger D. Kornberg 4. A direct link between genes and enzymatic reactions, known as the famous “one gene, one enzyme” hypothesis, was put forth by these 7. They developed the theory of genetic regulatory scientists who shared the Nobel Prize in mechanisms, showing how, on a molecular level, Physiology or Medicine, 1958. certain genes are activated and suppressed. Name a. George Wells Beadle and Edward Lawrie Tatum these famous Nobel laureates of 1965.
    [Show full text]
  • Biographical Notes on Scientists Involved in the Asilomar Process M.J
    International Dimensions of Ethics Education in Science and Engineering Case Study Series: Asilomar Conference on Laboratory Precautions Appendix D: Biographical Notes on Scientists involved in the Asilomar Process M.J. Peterson Version 1, June 2010 Edward A. Adelberg (1920-2009). PhD Yale 1949. Chair of Yale Department of Microbiology 1961-64 and 1970-72; a founding member of Yale Department of Genetics. Deputy Provost for the Biomedical Sciences, 1983-91. Specialist in plasmid biochemistry of E. coli. Ephraim Anderson (1911-2006). M.D., Durham University. Served in the Royal Army Medical Corps during World War II where he developed interests in Epidemiology. Researcher in Enteric Laboratory of the British Public Health Laboratory Service 1947, Deputy Director 1952, Director 1954-1978. Came to public notice for tracing sources of typhoid outbreaks in Zermatt (1963) and Aberdeen (1964). Built on earlier work by Japanese researchers to demonstrate the plasmid-based pathways by which bacteria could spread antibiotic resistance to others and became the world’s leading expert on antibiotic resistance. Also prominent in efforts to limit use of antibiotics in raising animals. Fellow of the Royal Society 1968; Companion of the Order of the British Empire 1976. Eric Ashby, Baron Ashby (1904-1992). Lecturer in Botany, Imperial College London 1931-35; Reader in Botany Bristol University 1935-37; Professor of Botany University of Sydney 1938-1946; Chair of Botany, University of Manchester 1947-50. Turned to administration as President and Vice-Chancellor of Queen's University, Belfast 1950-59; Master of Clare College in Cambridge University 1959-67 and Vice-Chancellor of Cambridge University 1967-1969.
    [Show full text]
  • Balcomk41251.Pdf (558.9Kb)
    Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr.
    [Show full text]
  • Members of Groups Central to the Scientists' Debates About Rdna
    International Dimensions of Ethics Education in Science and Engineering Case Study Series: Asilomar Conference on Laboratory Precautions Appendix C: Members of Groups Central to the Scientists’ Debates about rDNA Research 1973-76 M.J. Peterson Version 1, June 2010 Signers of Singer-Söll Letter 1973 Maxine Singer Dieter Söll Signers of Berg Letter 1974 Paul Berg David Baltimore Herbert Boyer Stanley Cohen Ronald Davis David S. Hogness Daniel Nathans Richard O. Roblin III James Watson Sherman Weissman Norton D. Zinder Organizing Committee for the Asilomar Conference David Baltimore Paul Berg Sydney Brenner Richard O. Roblin III Maxine Singer This case was created by the International Dimensions of Ethics Education in Science and Engineering (IDEESE) Project at the University of Massachusetts Amherst with support from the National Science Foundation under grant number 0734887. Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. More information about the IDEESE and copies of its modules can be found at http://www.umass.edu/sts/ethics. This case should be cited as: M.J. Peterson. 2010. “Asilomar Conference on Laboratory Precautions When Conducting Recombinant DNA Research.” International Dimensions of Ethics Education in Science and Engineering. Available www.umass.edu/sts/ethics. © 2010 IDEESE Project Appendix C Working Groups for the Asilomar Conference Plasmids Richard Novick (Chair) Royston C. Clowes (Institute for Molecular Biology, University of Texas at Dallas) Stanley N. Cohen Roy Curtiss III Stanley Falkow Eukaryotes Donald Brown (Chair) Sydney Brenner Robert H. Burris (Department of Biochemistry, University of Wisconsin) Dana Carroll (Department of Embryology, Carnegie Institution, Baltimore) Ronald W.
    [Show full text]