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Drug Interactions: a Napdi Center Recommended Approach S
Supplemental material to this article can be found at: http://dmd.aspetjournals.org/content/suppl/2018/05/07/dmd.118.081273.DC1 1521-009X/46/7/1046–1052$35.00 https://doi.org/10.1124/dmd.118.081273 DRUG METABOLISM AND DISPOSITION Drug Metab Dispos 46:1046–1052, July 2018 Copyright ª 2018 by The American Society for Pharmacology and Experimental Therapeutics Perspective Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach s Emily J. Johnson,1 Vanessa González-Peréz,2 Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune, and Mary F. Paine Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington (Y.S.L., J.D.U., A.E.R., D.D.S., J.S.M., M.F.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (E.J.J., V.G.-P., D.-D.T., Downloaded from M.F.P.); Department of Pharmaceutics (Y.S.L., J.D.U., D.D.S., J.S.M.) and Department of Medicinal Chemistry (A.E.R.), University of Washington, Seattle, Washington; and Department of Population Sciences, City of Hope, Duarte, California (J.S.M.) Received March 2, 2018; accepted May 3, 2018 dmd.aspetjournals.org ABSTRACT Pharmacokinetic interactions between natural products (NPs) and pharmacokinetic NPDIs. Guided information-gathering tools were used conventional medications (prescription and nonprescription) are a long- to score, rank, and triage NPs from an initial list of 47 candidates. standing but understudied problem in contemporary pharmacotherapy. -
Native Ground Covers & Low-Grows
Native Ground Covers & Low-Grows For the Sun Anemone canadensis (Canada windflower) Antennaria spp. (pussy toes) Arctostaphylos uva-ursi (bearberry) Campanula rotundifolia (thread leaf bellflower) Cheilanthes lanosa (hairy lip fern) Coreopsis spp. (tickseed) Dodecatheon meadia (shooting star) Drosera spp. (sundew) Empetrum nigrum (black crow berry) Eragrostis spectabilis (purple love grass) Gaylussacia baccata (black huckleberry) Geum spp. (prairie smoke) Houstonia caerulea (bluets) Hypoxis hirsuta (yellow star grass) Iris cristata (dwarf iris) Juniperus communis (common juniper) Juniperus horizontalis (creeping juniper) Meehania cordata (creeping mint) Mitella diphylla (bishop’s cap) Opuntia humifusa (prickly pear) Paxistima canbyi (cliff green) Phlox subulata (moss phlox) Polemonium spp. (Jacob’s ladder) Sarracenia purpurea (pitcher plant) Sedum nevii (stonecrop) Sedum ternatum (stonecrop) Courtesy of Dan Jaffe Propagator and Stock Bed Grower New England Wild Flower Society [email protected] Native Ground Covers & Low-Grows Sibbaldiopsis tridentata (three toothed cinquefoil) Silene spp. (campion) Sisyrinchium angustifolium (blue eyed grass) Stokesia laevis (Stokes aster) Talinum calycinum (fame flower) Tellima grandiflora (frigecups) Uvularia sessifolia (bellflower) Vaccinium angustifolium (low-bush blueberry) Vaccinium macrocarpon (cranberry) Vaccinium vitis-idaea(mountain cranberry) Viola pedata (birds-foot violet) For the Shade Anemone spp. (Hepatica) Allium tricoccum (ramps) Asarum spp. (wild ginger) Asplenium spp. (spleenwort) Carex spp. (sedge) Chamaepericlymenum canadense (bunchberry) Chimaphila maculata (spotted wintergreen) Chrysogonum virginianum (green and gold) Claytonia virginica (spring beauty) Clintonia borealis (blue bead lily) Coptis trifolia (goldthread) Dicentra canadensis (squirrel corn) Dicentra cucullaria (Dutchmen’s breaches) Epigaea repens (mayflower) Courtesy of Dan Jaffe Propagator and Stock Bed Grower New England Wild Flower Society [email protected] Native Ground Covers & Low-Grows Erythronium spp. -
Herbal Pharmacy
ISSN: 2644-2957 DOI: 10.33552/OJCAM.2020.04.000580 Online Journal of Complementary & Alternative Medicine Opinion Article Copyright © All rights are reserved by M’Lou Barnett Herbal Pharmacy M’Lou Barnett* Integrative Medicine Fellow, North Western University of Louisiana, USA *Corresponding author: M’Lou Barnett, Integrative Medicine Fellow, North Received Date: March 20, 2020 Western University of Louisiana, USA. Published Date: May 14, 2020 Opinion With 50% of Americans utilizing Complementary Alternative know. Nurses & health professionals will have a better knowledge Medicines, knowledge of herbal supplements is limited among Surgery does not cure or benefit all illnesses, as nurses astutely of Herbal Pharmacy to better inform their patients. the general population. Unfortunately, most Americans rely on the advice of health food store employees to select botanical GAIA Herbs are the Best Brands of Herbal Medicine supplements. Aloe Vera-RX: Gel soothes pain & Promotes healing of wounds. The top Herbal supplements will be presented to educate Ashwagandha-RX: Calming adaptogen for anxiety, Stress, nurses. These include Aloe Vera, Ashwagandha, Black Cohosh, insomnia & Improving Cognitive function. Butterbur, California Poppy, Capsicum, Chamomile, Cinnamon, Dandelion, Echinacea, Elderberry, Evening Primrose, Fennel, Black Cohosh-RX: sweats, sleep disturbances, irritability); Premenstrual Syndrome & Feverfew, Garlic, Ginger, Ginkgo, Ginseng, Goldenseal, Green Tea, Menopausal Symptoms (hot flashes, night Hibiscus, Horse Chestnut, Kava, Lemon Balm, Licorice, Milk Thistle, Dysmenorrhea. Peppermint, Red Yeast Rice, St. John’s Wort, Saw Palmetto, Skullcap, Butterbur-RX: Allergies & migraine prophylaxis. Soy, Tea Tree Oil, Turmeric, Uva Ursi & Valerian. California Poppy-RX: Insomnia, Sedation, Aches, Nervous Each herb topics will include: Common Latin Binomial Name, Agitation, Prolong sleep & Anxiolytic. -
Goldenseal Assistant Authors: Kathleen Bennett MS, Kevin Spelman Phd, Michael Tims Phd
An Appalachian Plant Monograph Chief author and editor: Andrew Pengelly PhD. Goldenseal Assistant authors: Kathleen Bennett MS, Kevin Spelman PhD, Michael Tims PhD. Hydrastis canadensis L. Peer review board: Paul Bergner AHG, Hans Wolmuth PhD. 1. Taxonomy Editorial team: Bevin Clare MS, Mimi Hernandez MS, James Snow Hydrastis canadensis L. MA, Amanda Vickers MS. Family: Ranunculaceae (buttercup family) Hydrastis is a monotypic genus, which some authors have placed in a Citation Instruction: Pengelly, A., separate family – Hydrastidaceae (Tobe & Keating, 1985) – though Bennett, K., Spelman, K., & Tims, M. more recent genetic studies confirm H. canadensis as the basal branch (2012). Appalachian plant of the Ranunculaceae, albeit with close ties to the Berberidaceae family monographs: Hydrastis canadensis L., (Ro, Keener, & McPheron, 1997; Chu, Li, & Qi, 2006). goldenseal. Appalachian Center for EthnoBotanical Studies. Common names: golden seal, eyebalm, eyeroot, golden root, ground raspberry, Indian dye, Indian turmeric, jaundice root, orange root, Cover illustration By Peggy Duke yellowroot, yellow pucoon. APPALACHIAN PLANT MONOGRAPHS Hydrastis canadensis 1. Taxonomy 1 2. Botanical description and 2. Botanical description distribution and distribution 2 Hydrastis canadensis is an herbaceous perennial growing from a short yellow rhizome. The rhizome has a knotty appearance bearing 3. Traditional use 3 remnants of stems or stem scars (Tobe & Keating, 1985). During the first year vegetative growth consists of a pair of leaf-like cotyledons on 4. Phytochemistry 4 long petioles. In the second year a few inch long ‘footstalk’ emerges bearing one palmately-lobed or maple-shaped leaf with biserrate 5. Pharmacology and margins near the apex. Over the next two years a true stem arises attaining a height of one foot or more, bearing two or three petiolate toxicology 11 leaves arranged alternately on the stem. -
Combining Herbs and Essential Oils This Presentation Explores How
Hawthorn University Holistic Health and Nutrition Webinar Series 2017 www.hawthornuniversity.org Presented by David Crow, L.Ac. Combining Herbs and Essential Oils This presentation explores how essential oils and aromatherapy can be integrated with herbal treatments for added therapeutic effects and benefits. It explores which essential oils can be safely combined, and how, with herbs according to therapeutic functions: ) Expectorant, mucolytic, decongestant and antitussive herbs ) Nervine relaxant, sedative and anxiolytic herbs ) Demulcent herbs ) Anti-spasmotic and analgesic herbs ) Antimicrobial herbs ) Cholagogue and laxative herbs ) Immune modulating and immune stimulating herbs ) Adaptogen, trophorestorative and neuroendocrine regulating herbs ) Antiinflammatory herbs ) Emmenagogue and uterine tonic herbs Learning Objectives: ) When and how essential oils and aromatherapy are a primary, adjunct or contraindicated treatment ) To understand the compatibility or lack of compatibility of specific groups and species of essential oils and specific groups and species of herbs ) Simple combinations of herbs and essential oils for specific therapeutic benefits Introduction ) General suggestions for how to use safely therapeutic groups of essential oils in combinations with groups of herbs. ) Does not give detailed methods of use of the oils. ) Does not give any specific dosages or uses of herbs. ) Please do not use herbs without studying them in detail. ) Please use essential oils according to safe methods of applications ) Do not take internally ) Do not apply undiluted to the skin Difficulties classifying essential oils into therapeutic categories Where do the claims about therapeutic actions of essential oils come from? 1. Empirical evidence from long history of use of aromatic plants 2. Modern scientific studies 3. Claims made about essential oils through MLM companies and spread on the internet Many claims about the functions of essential oils are not substantiated or established. -
Eric Brand Published By: BLUE POPPY PRESS a Division of Blue Poppy Enterprises, Inc
A Clinician's Guide to Using Granule Extracts by Eric Brand Published by: BLUE POPPY PRESS A Division of Blue Poppy Enterprises, Inc. 1990 North 57th Court, Unit A BOULDER, CO 80301 First Edition, June 2010 ISBNl-891845-51-9 ISBN 978-1-891845-51-2 LCCN #2010907367 COPYRIGHT @ BLUE POPPY PRESS, 2010. All Rights Reserved. All rights reserved. No part of this book may be reproduced, stored in a retrieval system, transcribed in any fonn or by any means, e1ectronic, mechanical, photocopy, recording, or any other means, or translated into any language without the prior written permission of the publisher. DISCLAIMER: The information in this book is given in good faith. Howeve乌 the author and the publishers cannot be held responsible for any error or omission. The publishers wiU not accept liabilities for any injuries or damages caused to the reader that may result from the reader's acting upon or using the content contained in this book. The publishers make this information avail able to English-language readers for research and scholarly purposes only. The publishers do not advocate nor endorse self-medication by laypersons. Chinesemedicine is a professional medicine. Laypersons interested in availing themselves of the treatments described in this book should seek out a qualified professional practitioner of Chinese medicine. 10 9 8 7 6 5 4 3 2 1 Printed at Edwards Brothers, Ann Arbor,扣1I on acid free paper and soy inks Cover and text design by Eric Brearton with Honora L. Wolfe Table of Contents Dedication . .. .. vii Preface ............................................ ix 1 Why a Book on Granules? . -
Native Plants North Georgia
Native Plants of North Georgia A photo guide for plant enthusiasts Mickey P. Cummings · The University of Georgia® · College of Agricultural and Environmental Sciences · Cooperative Extension CONTENTS Plants in this guide are arranged by bloom time, and are listed alphabetically within each bloom period. Introduction ................................................................................3 Blood Root .........................................................................5 Common Cinquefoil ...........................................................5 Robin’s-Plantain ..................................................................6 Spring Beauty .....................................................................6 Star Chickweed ..................................................................7 Toothwort ..........................................................................7 Early AprilEarly Trout Lily .............................................................................8 Blue Cohosh .......................................................................9 Carolina Silverbell ...............................................................9 Common Blue Violet .........................................................10 Doll’s Eye, White Baneberry ...............................................10 Dutchman’s Breeches ........................................................11 Dwarf Crested Iris .............................................................11 False Solomon’s Seal .........................................................12 -
Early Diverging Eudicots
1/31/20 Berberidaceae - barberry family • widespread in temperate regions of Northern hemisphere - ArctoTertiary relict distribution • 3 native genera to Wisconsin + Berberis • small shrubs (Berberis) or herbs (rest of family). CA 3+3 CO 3+3 A 12-18 G 1 [monocarpic] Early Berberis thunbergii Diverging Japanese barberry Eudicots 1 2 Berberidaceae - barberry family Berberidaceae - barberry family Berberis thunbergii Japanese barberry • Puccinia graminis Fruits = berry Berberis vulgaris Berberis vulgaris Common barberry Common barberry • alternate host of the stem rust of wheat • alternate host of the stem rust of wheat • programs to irradicate plant in midwest • programs to irradicate plant in midwest 3 4 1 1/31/20 Berberidaceae - barberry family Berberidaceae - barberry family Caulophyllum thalictroides - Blue cohosh Jeffersonia diphylla - twinleaf • leaves 3X compound • Special concern species in Wisconsin. One species in • developing ovules break ovary wall so are Eastern North America and one species in Eastern Asia. naked seeds with fleshy blue seed coats • medicinally important for North American • Only member of the family that is 4-merous rather than 3- native Americans merous 5 6 Berberidaceae - barberry family Berberidaceae - barberry family Forms large colonies of deeply lobed, May-apple and other members of the peltate leaves whose umbrella like family are attacked by the same family aspect is emphasized as they emerge of rusts - Pucciniaceae. from the ground, slits in anthers Podophyllum peltatum Podophyllum peltatum May-apple -
Corydalis Flavula (Raf.) DC
Corydalis flavula (Raf.) DC. yellowyellow fumewort fumewort, Page 1 State Distribution Photo by Bradford S. Slaughter Best Survey Period Jan Feb Mar Apr May Jun Jul Aug Sept Oct Nov Dec Status: State threatened capsules containing black, shining seeds. Global and state rank: G5/S2 Range: Yellow fumewort is widespread in the eastern and central United States and Canada, where the species Other common names: yellow corydalis; yellow occurs from Rhode Island south to Florida, west to harlequin Michigan, Illinois, Iowa, and South Dakota, and south to Oklahoma, Arkansas, and Louisiana (Gleason and Family: Papaveraceae (poppy family) Cronquist 1991). The species is considered rare in Connecticut, Delaware, Georgia, Nebraska, New Jersey, Synonyms: Capnoides flavulum(Raf.) �unt�e; Fumaria New York, and Ontario (NatureServe 2009). flavula Raf. State distribution: Yellow fumewort is restricted Taxonomy: The Papaveraceae is a family of ca. 660 to southwestern Lower Michigan, where the species species of herbaceous plants with watery or colored, is known from 17 occurrences in Berrien, Cass, acrid sap, pinnately lobed leaves, 2- or 3-merous �alama�oo, and Calhoun counties. hypogynous flowers, biseriate corollas commonly with 4 or 6 petals, capsular fruits with arillate seeds, and Recognition: Yellow fumewort is a small, semi- the presence of various alkaloids within laticifers or succulent, spreading or sprawling annual forb to secretory cells (Zomlefer 1994). The genus Corydalis is 30 cm tall. The species is characteri�ed by green to often segregated into the family Fumariaceae, which is glaucous, cauline, alternate, bipinnately dissected recogni�ed by some botanists as a distinct family on the leaves and axillary racemes with few to 10 or more basis of several morphological characteristics that often, irregular flowers with 4 unequal yellow petals. -
Spring Wildflowers Strouds Run Area
$2.00 Spring Wildflowers of the Strouds Run Area A publication of the Strouds Run Field Guide #2 First Corrected Edition Spring Wildflowers of the Strouds Run Area is a publication of the Friends of Strouds Run State Park (www.friendsofstroudsrun.org). It is published with the assistance of the Athens Conservancy (www.athensconservancy.org) and Athens Trails (www.athenstrails.org). Coming publications in this series: 1. Geology of the Strouds Run Area: already published 2. Spring Wildflowers of the Strouds Run Area: now published! 3. Invasive Exotic Plants of the Strouds Run Area: coming late May, 2009 4. Ferns and Lycopods of the Strouds Run Area: coming late June, 2009 5. Woody Plants of the Strouds Run Area: coming late July, 2009 6. Summer Wildflowers of the Strouds Run Area: coming late August, 2009 7. Birds of the Strouds Run Area: date to be determined 8. Reptiles and Amphibians of the Strouds Run Area: date to be determined 9. Mammals of the Strouds Run Area: date to be determined 10. Vascular Plant Checklist of the Strouds Run Area: date to be determined Bibliographic data: Knouse, John. Spring Wildflowers of the Strouds Run Area. Photographs by John Knouse, Melanie Schori, and others. Friends of Strouds Run State Park, Athens, Ohio. First edition, fourth corrected printing, May, 2016. 15pp, 57 photos. ISBN 978-1-945175-95-4. Copyright 2009, 2014: Friends of Strouds Run State Park PO Box 514, Athens, OH 45701 www.friendsofstroudsrun.org Many thanks to Phil Cantino for his invaluable assistance in creating this work. Photo Acknowledgments: Cover photo: 26. -
Flora Spring Flowering Native Plants of Washington D.C. and Vicinity
Spring Flowering Native Plants of Washington, D.C. and Vicinity Presentation by Rod Simmons Ford Nature Center March 26, 2011 Spring ephemerals are wildflowers of the deciduous forest that leaf out and bloom in early through mid- spring, are pollinated, and largely disappear before the forest canopy substantially leafs out. Extensive, intermixed colonies of these plants carpet the floor of rich, mesic forests and floodplain forests throughout the region. Turkey Run Park. Photo by R.H. Simmons Photo by R.H. Simmons Holmes Run Gorge, Fairfax County, Virginia Photo by G.P. Fleming Basic Mesic Forest with Claytonia virginica – Turkey Run Park, Fairfax County, Virginia Potomac Gorge Photo by G.P. Fleming Photo by R.H. Simmons Rich Alluvial Floodplain Forest at Dora Kelley Nature Park, eastern end of the Holmes Run Gorge in the City of Alexandria, Virginia Lush foliage of spring ephemerals in late spring, Holmes Run Gorge Photo by R.H. Simmons Late spring foliage of Rich Cove Forest at Lost Mountain, Washington County, Virginia Photo by G.P. Fleming Photo by R.H. Simmons Spring ephemerals have evolved along with other plants, animals, and microorganisms over millennia, each occupying its special niche, to form the Eastern Deciduous Forest that many of us live in the midst of. Today, many fine remnants of this once-vast forest still remain in our region, but there is also much fragmentation and disturbance, including new threats such as invasive exotic plants and insects. Photo by R.H. Simmons Photo by G.P. Fleming Basic Mesic Forest with large clone of Podophyllum peltatum – Turkey Run Park, Fairfax County, Virginia PhotoPhoto by Dianne by R.H. -
Dicentra Cucullaria – Dutchman's Breeches
Friends of the Arboretum Native Plant Sale Dicentra cucullaria – Dutchman’s Breeches COMMON NAME: Dutchman’s Breeches SCIENTIFIC NAME: Dicentra cucullaria – This name comes a Greek word meaning two spurred and cucullaria refers to a hood. FLOWER: This is a very distinct shape. It is white, tinged with cream or yellow and resembles a pair of pantaloons upside down. There will be 2 to 6 pairs of these flowers on a stalk. BLOOMING PERIOD: April SIZE: 5 to 10 inches high BEHAVIOR: This spring ephemeral appears as soon as the ground thaws, blooms, sets it seed and dies back for the season in early June. SITE REQUIREMENTS: Dry to medium forests, cliffs. Flourishes on slopes with loose, rich, sandy loam. Not good for wet sites. Needs the shade of large trees such as sugar maple, basswood or red oak. NATURAL RANGE: Most of the eastern United States. Found in most of Wisconsin. SPECIAL FEATURES: This is a delicate plant with lacy leaves and the distinctly shaped flowers. The leaves are all basal and each is divided into three secondary leaflets. It takes several years for young seedlings to reach flowering size. SUGGESTED CARE: The corms (bulbs) should be planted close to the surface and well watered. Allow a cluster of showy patches to develop before thinning. Digging the corms should happen after the leaves have died back in June. In the spring it helps to remove a heavy leaf layer, especially oak leaves, so the emerging leaves get sunlight. COMPANION PLANTS: Wild leek, blue cohosh, spring beauty, toothwort, bloodroot. SPECIAL NOTE: A very similar plant, Squirrel Corn (Dicentra Canadensis) has similar leaves and flowers in a similar arrangement.