Programming Cellular Function
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Guide to Publication Policies of the Nature Journals
GUIDE TO PUBLICATION POLICIES OF THE NATURE JOURNALS Last updated on 30 April 2009. Editorial Policies NATURE JOURNALS' POLICIES ON PUBLICATION ETHICS Nature journals' authorship policy Being an author The Nature journals do not require all authors of a research paper to sign the letter of submission, nor do they impose an order on the list of authors. Submission to a Nature journal is taken by the journal to mean that all the listed authors have agreed all of the contents. The corresponding (submitting) author is responsible for having ensured that this agreement has been reached, and for managing all communication between the journal and all co-authors, before and after publication. Any changes to the author list after submission, such as a change in the order of the authors, or the deletion or addition of authors, needs to be approved by a signed letter from every author. Responsibilities of senior team members on multi-group collaborations The editors at the Nature journals assume that at least one member of each collaboration, usually the most senior member of each submitting group or team, has accepted responsibility for the contributions to the manuscript from that team. This responsibility includes, but is not limited to: (1) ensuring that original data upon which the submission is based is preserved and retrievable for reanalysis; (2) approving data presentation as representative of the original data; and (3) foreseeing and minimizing obstacles to the sharing of data, materials, algorithms or reagents described in the work. Author contributions statementsAuthors are required to include a statement of responsibility in the manuscript that specifies the contribution of every author. -
The Nature Index Journals
The Nature Index journals The current 12-month window on natureindex.com includes data from 57,681 primary research articles from the following science journals: Advanced Materials (1028 articles) American Journal of Human Genetics (173 articles) Analytical Chemistry (1633 articles) Angewandte Chemie International Edition (2709 articles) Applied Physics Letters (3609 articles) Astronomy & Astrophysics (1780 articles) Cancer Cell (109 articles) Cell (380 articles) Cell Host & Microbe (95 articles) Cell Metabolism (137 articles) Cell Stem Cell (100 articles) Chemical Communications (4389 articles) Chemical Science (995 articles) Current Biology (440 articles) Developmental Cell (204 articles) Earth and Planetary Science Letters (608 articles) Ecology (259 articles) Ecology Letters (120 articles) European Physical Journal C (588 articles) Genes & Development (193 articles) Genome Research (184 articles) Geology (270 articles) Immunity (159 articles) Inorganic Chemistry (1345 articles) Journal of Biological Chemistry (2639 articles) Journal of Cell Biology (229 articles) Journal of Clinical Investigation (298 articles) Journal of Geophysical Research: Atmospheres (829 articles) Journal of Geophysical Research: Oceans (493 articles) Journal of Geophysical Research: Solid Earth (520 articles) Journal of High Energy Physics (2142 articles) Journal of Neuroscience (1337 articles) Journal of the American Chemical Society (2384 articles) Molecular Cell (302 articles) Monthly Notices of the Royal Astronomical Society (2946 articles) Nano Letters -
List Stranica 1 Od
list product_i ISSN Primary Scheduled Vol Single Issues Title Format ISSN print Imprint Vols Qty Open Access Option Comment d electronic Language Nos per volume Available in electronic format 3 Biotech E OA C 13205 2190-5738 Springer English 1 7 3 Fully Open Access only. Open Access. Available in electronic format 3D Printing in Medicine E OA C 41205 2365-6271 Springer English 1 3 1 Fully Open Access only. Open Access. 3D Display Research Center, Available in electronic format 3D Research E C 13319 2092-6731 English 1 8 4 Hybrid (Open Choice) co-published only. with Springer New Start, content expected in 3D-Printed Materials and Systems E OA C 40861 2363-8389 Springer English 1 2 1 Fully Open Access 2016. Available in electronic format only. Open Access. 4OR PE OF 10288 1619-4500 1614-2411 Springer English 1 15 4 Hybrid (Open Choice) Available in electronic format The AAPS Journal E OF S 12248 1550-7416 Springer English 1 19 6 Hybrid (Open Choice) only. Available in electronic format AAPS Open E OA S C 41120 2364-9534 Springer English 1 3 1 Fully Open Access only. Open Access. Available in electronic format AAPS PharmSciTech E OF S 12249 1530-9932 Springer English 1 18 8 Hybrid (Open Choice) only. Abdominal Radiology PE OF S 261 2366-004X 2366-0058 Springer English 1 42 12 Hybrid (Open Choice) Abhandlungen aus dem Mathematischen Seminar der PE OF S 12188 0025-5858 1865-8784 Springer English 1 87 2 Universität Hamburg Academic Psychiatry PE OF S 40596 1042-9670 1545-7230 Springer English 1 41 6 Hybrid (Open Choice) Academic Questions PE OF 12129 0895-4852 1936-4709 Springer English 1 30 4 Hybrid (Open Choice) Accreditation and Quality PE OF S 769 0949-1775 1432-0517 Springer English 1 22 6 Hybrid (Open Choice) Assurance MAIK Acoustical Physics PE 11441 1063-7710 1562-6865 English 1 63 6 Russian Library of Science. -
Curriculum Vitae – WENJUN ZHANG
Curriculum Vitae – WENJUN ZHANG Department of Chemical and Biomolecular Engineering, University of California, Berkeley 201 Gilman Hall, Berkeley, CA 94720 http://www.cchem.berkeley.edu/wzgrp Tel: (510)643-8682, [email protected] https://scholar.google.com/citations?hl=en&user=NUYglIoAAAAJ&view_op=list_works&sortby=pubdate PROFESSIONAL EXPERIENCE Co-director, Agilent/UC Berkeley Synthetic Biology Institute (SBI) 2019 to current Associate Professor, Dept. of Chemical and Biomolecular Engineering, UC Berkeley 2018 to current Biologist Faculty Sci/Engr, Lawrence Berkeley National Laboratory 2014 to current Assistant Professor, Dept. of Chemical and Biomolecular Engineering, UC Berkeley 2011-2018 EDUCATION Research Fellow, Harvard Medical School (adviser: Christopher T. Walsh) 2009-2011 Ph.D., Chemical Engineering, University of California, Los Angeles (adviser: Yi Tang) 2004-2009 M.S., Biochemistry and Molecular Biology, Nanjing University, China (adviser: Genxi Li) 2002-2004 B.S., Biochemistry, DII, Nanjing University, China 1998-2002 AWARDS AND HONORS Presidential Early Career Award for Scientists and Engineers (PECASE) (2019) Scialog Fellow, Research Corporation and the Gordon and Betty Moore Foundation (2018) American Cancer Society Research Scholar (2017) Chau Hoi Shuen Foundation Women in Science Program New Research Grant Award (2017) Chan Zuckerberg Biohub Investigator (2017) Alfred P . Sloan Research Fellow (2016) Paul Saltman Memorial Award in Bioinorganic Chemistry (2016) NIH Director's New Innovator Award (2015) Hellman Fellow (2015) F1000Prime Faculty (Chemical Biology, Small Molecule Chemistry section) (2015) The Charles R. Wilke Endowed Chair in Chemical Engineering, UC Berkeley (2014) University of California Cancer Research Coordinating Committee Research Award (2013) Pew Scholar (2012) Energy Biosciences Institute Proposal Award (2011, 2014) Outstanding Ph.D. -
Biography – Dr. Ehud Shapiro Function Professor of Computer Science and Biology, Weizmann Institute of Science, Israel Educati
Biography – Dr. Ehud Shapiro Function Professor of Computer Science and Biology, Weizmann Institute of Science, Israel Education & Professional Born in Jerusalem in 1955, Ehud Shapiro was awarded a B.A./B.Sc. Background degree with distinction in Mathematics and Philosophy from Tel Aviv University in 1979, and a Ph.D. in Computer Science from Yale Univer- sity in 1982. His doctoral studies with Prof. Dana Angluin attempted to provide an algorithmic interpretation to the noted philosopher of science Karl Popper's approach to scientific discovery. Joining the Weizmann Institute’s Department of Computer Science and Applied Mathematics in 1982 as a postdoctoral fellow, Prof. Shapiro was inspired by the Japanese Fifth Generation Computer Systems project to invent a high- level programming language for parallel and distributed computer sys- tems, named Concurrent Prolog. In 1993, Prof. Shapiro took a leave of absence from the Weizmann Institute to found and serve as CEO of Ubique Ltd., an Israeli Internet software pioneer. Prof. Shapiro returned to the Weizmann Institute in August 1998, where he is now an associate professor in the Depart- ments of Computer Science and Applied Mathematics, and Biological Chemistry, and incumbent of the Harry Weinrebe Chair of Computer Science and Biology. Preparing for his return to academia, Prof. Shapiro ventured into study of molecular biology. Initially curious about the origins of life, he was sidetracked into attempting to build a computer from biological mole- cules, guided by a vision of "A Doctor in a Cell": a biomolecular com- puter that operates inside the living body, programmed with medical knowledge to diagnose diseases and produce the requisite drugs. -
Guide to Authors and Referees
Guide to Authors and Referees • Single molecule chemistry of small molecules and biomolecules ABOUT THE JOURNAL • Theoretical simulations and modelling of biomolecules • Molecular recognition AIMS AND SCOPE OF THE JOURNAL • Small molecular model systems for metalloenzymes Nature Chemical Biology is a multidisciplinary journal that publishes • Molecular machines papers of the highest quality and significance in all areas of chemical • Pharmacologically active natural products biology. The journal is particularly interested in contributions from • Biosynthetic pathway elucidation chemists who are applying the principles, language and tools of • Chemical approaches to protein interaction networks chemistry to the understanding of biological problems and from biol- • Chemical ecology ogists who are interested in understanding biological processes at the molecular level. Priority is given to work that reports fundamental Expanding Biology through Chemistry new advances in biology or chemistry. Research areas at the interface • Chemical genetics and High Throughput Screening of chemistry and biology covered in the journal include, but are not • Biomolecular and small molecular array fabrication and valida- limited to: tion • Chemical insights into drug design and development Chemical Synthesis • Synthetic biology • Diversity-oriented synthesis • Unnatural biomolecular analogs in biological systems • Nucleic acid templated synthesis • Chemical genomics • Biomolecular modification and labelling chemistry • Chemical regulation of biosynthetic pathways -
From Fifth Generation Computing to Skill Science
New Generation Computing (2019) 37:141–158 https://doi.org/10.1007/s00354-019-00058-y From Fifth Generation Computing to Skill Science A Biographical Essay of Koichi Furukawa Tomonobu Ozaki1 · Randy Goebel2 · Katsumi Inoue3,4,5 Received: 7 February 2019 / Accepted: 10 April 2019 / Published online: 25 April 2019 © The Author(s) 2019 Abstract Professor Koichi Furukawa, an eminent computer scientist and former Editor-in- Chief of the New Generation Computing journal, passed away on January 31, 2017. His passing was a surprise, and we were all shocked and saddened by the news. To remember the deceased, this article reviews the great career and contributions of Professor Koichi Furukawa, focusing on his research activities on the foundation and application of logic programming. Professor Furukawa had both a deep understand- ing and broad impact on logic programming, and he was always gentle but persistent in articulating its value across a broad spectrum of computer science and artifcial intelligence research. This article introduces his research along with its insightful and unique philosophical framework. Keywords Institute for New Generation Computer Technology · Logic programming · Inductive logic programming · Skill science * Tomonobu Ozaki [email protected] Randy Goebel [email protected] Katsumi Inoue [email protected] 1 College of Humanities and Sciences, Nihon University, Tokyo, Japan 2 Department of Computing Science, University of Alberta, Edmonton, Canada 3 National Institute of Informatics, Tokyo, Japan 4 Department of Informatics, SOKENDAI (The Graduate University for Advanced Studies), Tokyo, Japan 5 Department of Computer Science, School of Computing, Tokyo Institute of Technology, Tokyo, Japan Vol.:(0123456789)123 142 New Generation Computing (2019) 37:141–158 Fig. -
Lineage Trees Reveal Cells' Histories 23 February 2012
Lineage trees reveal cells' histories 23 February 2012 In recent years, a number of controversial claims comparing a number of genetic sequences called have been made about the female mammal's egg microsatellites - areas where mutations occur like supply - that it is renewed over her adult lifetime clockwork - they can place cells on trees to reveal (as opposed to the conventional understanding their developmental history. that she is born with all of her eggs), and that the source of these eggs is stem cells that originate in A number of papers published by Shapiro, his team the bone marrow. Now, Weizmann Institute and collaborators in recent months have scientists have disproved one of those claims and demonstrated the power and versatility of this pointed in new directions toward resolving the method. One study, for instance, lent support to the other. Their findings, based on an original method notion that the adult stem cells residing in tiny for reconstructing lineage trees for cells, were crypts in the lining of the colon do not harbor, as published online today in PLoS Genetics. thought, "immortal DNA strands." Immortal strands may be retained by dividing stem cells if they The method, developed over several years in the always relegate the newly-synthesized DNA to the lab of Prof. Ehud Shapiro of the Institute's differentiating daughter cell and keep the original Biological Chemistry, and Computer Science and stand in the one that remains a stem cell. Applied Mathematics Departments, uses mutations in specific genetic markers to determine which A second study addressed an open question about cells are most closely related and how far back developing muscle cells. -
Martin D. Burke – Curriculum Vitae
Martin D. Burke – Curriculum Vitae Professor of Chemistry phone: (217) 244-8726 University of Illinois at Urbana-Champaign email: [email protected] 454 Roger Adams Laboratory web: http://www.scs.illinois.edu/burke 600 South Mathews Ave. born: Feb. 5, 1976, Westminster, MD, USA Urbana, IL 61801 ________________________________________________________________________________________________________________________________________________________________________________________________________ Education 1998-2005 Harvard Medical School & Massachusetts Institute of Technology Division of Health Sciences and Technology National Institutes of Health Fellow in the Medical Scientist Training Program Boston, Massachusetts, Degree awarded: M.D. 1999-2003 Harvard University, Department of Chemistry and Chemical Biology Howard Hughes Medical Institutes Predoctoral Fellow Thesis advisor: Professor Stuart L. Schreiber Cambridge, Massachusetts, Degree Awarded: Ph.D. 1994-1998 Johns Hopkins University Howard Hughes Medical Institute Undergraduate Research Fellow Research advisors: Professors Henry Brem and Gary H. Posner Baltimore, Maryland, Degree Awarded: B.A. Chemistry Appointments 2018 Associate Dean of Research, Carle-Illinois College of Medicine 2014 Professor of Chemistry, University of Illinois at Urbana-Champaign 2011 Associate Professor of Chemistry, University of Illinois at Urbana-Champaign 2009-2015 Early Career Scientist, Howard Hughes Medical Institute 2009 Affiliate Faculty, Dept. of Biochemistry, University of Illinois at Urbana-Champaign -
Springernature 助力您的科研事业
Illustration inspired by the work of John Maynard Keynes Maynard John of work the by inspired Illustration SpringerNature 助力您的科研事业 崔丽丽 授权经理 2018年11月09日 1 大纲 1. SpringerNature 出版社介绍 2. Springer期刊介绍 3. Nature 期刊介绍 Springer Nature product overview 2 SpringerNature 出版社介绍 1.0 [Title for presentation / Date to go here] 3 施普林格·自然集团(Springer Nature)在2015年由自然出版集团、帕尔格雷 夫·麦克米伦、麦克米伦教育、施普林格科学与商业媒体合并而成。是一家全 球领先的从事科研、教育和专业出版的机构。集团旗下汇聚了一系列备受尊 敬和信赖的品牌,以各种创新的产品和服务,为客户提供优质的内容。 施普林格·自然集团是世界上最大的学术书籍出版公司,出版全球最具影响力 的期刊,也是开放研究领域的先行者。 集团在全球约有1.3万名员工,遍及50多个国家。 Springer Nature product overview 4 我们的领先品牌 施普林格(Springer)创立于1842年,是全球 《自然》杂志(Nature)创刊于1869年,是 麦克米伦教育(Macmillan Education)是全 领先的科学、技术和医学出版机构,公司以创 全球被引用最多的科学期刊,年引用量超过50 球第三大英语教材和课程资料出版机构,也是 新的信息产品和服务让学术界、科研机构和企 万次。作为全球首屈一指的多学科科学期刊, 本地K12基础教育出版商,此外还通过帕尔格 业研发部门的科研人员享有高品质的内容。施 其影响因子高达41.456。《自然》的读者包括 雷夫(Palgrave)出版和销售久负盛名的高等 普林格拥有世界上最重要的科学、技术和医学 了数百万科学家和学生,遍及世界各地4000余 教育图书。他们共同服务于50个市场的客户, 类电子图书数据库和回溯图书档案文库之一, 家机构,每月有350万名独立用户在其网站上 并为遍及全球120个国家的客户提供高质量的 以及种类全面的开放获取期刊。 阅览超过800万页的内容。 内容和创新的数字产品与服务。 BioMed Central是全球最大的开 Apress是一家致力于满足IT专业 《科学美国人》(Scientific 帕尔格雷夫·麦克米伦(Palgrave 放获取出版机构,出版超过286种 人士、软件开发者及程序员需求 American)创刊于1845年,是美 Macmillan)是一家面向人文及社 经同行评审的开放获取刊物,涉及 的技术出版机构。Apress以纸本 国持续出版历史最悠久的杂志,也 会科学(HSS)的全球性学术与商 生物学、生物医学和医学等领域。 和电子版形式出版1500余种图书,是大众读者获取科技信息及政策的 业出版机构。作为首家不设边界的 其注册用户超过180万,因而能够 是全球IT专业人士、软件开发者 重要权威来源。其纸本在全球有350 HSS出版机构,其出版篇幅不限, 有针对性地为各种专长、职称和学 和商业领袖的权威信息来源。 万读者,网站ScientificAmerican.com 覆盖各种业务模式,让读者和作者 科的人士带来机会。 月平均阅览量达550万人次。 从其一家出版机构就能获得最佳的 专业学习和学术资料。 Springer Nature product overview 追求卓越 5 Springer出版社与诺贝尔奖、费尔兹奖获得者 -
Covalent Targeting of the Vacuolar H+-Atpase Activates Autophagy Via Mtorc1 Inhibition
ARTICLES https://doi.org/10.1038/s41589-019-0308-4 Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition Clive Yik-Sham Chung1,2,6, Hijai R. Shin3,4,6, Charles A. Berdan5, Breanna Ford 5, Carl C. Ward2,3, James A. Olzmann 5, Roberto Zoncu 3,4* and Daniel K. Nomura 1,2,3,5* Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1 blockade. Here, we have coupled screening of a covalent ligand library with activity-based protein profiling to discover EN6, a small-molecule in vivo activator of autophagy that covalently targets cys- teine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. Consistently, EN6 clears TDP-43 aggregates, a causative agent in frontotem- poral dementia, in a lysosome-dependent manner. Our results provide insight into how the v-ATPase regulates mTORC1, and reveal a unique approach for enhancing cellular clearance based on covalent inhibition of lysosomal mTORC1 signaling. utophagy is central to the maintenance of organismal activators of autophagy can be beneficial in both cell and animal homeostasis in both physiological and pathological situa- models of these diseases, by both degrading intracytoplasmic aggre- Ations. It is an essential, conserved lysosomal degradation gates and by preventing associated cell death9–11. -
Concept of Law in Biology Synthetic Biology – Towards an Engineering Science
European Review, Vol. 22, No. S1, S102–S112 r 2014 Academia Europæa. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence http://creativecommons.org/licenses/by/3.0/ doi:10.1017/S1062798713000793 Concept of Law in Biology Synthetic Biology – Towards an Engineering Science MARC-DENIS WEITZE* and ALFRED PU¨ HLER** *acatech – Deutsche Akademie der Technikwissenschaften, Hofgartenstraße 2, 80539 Munich, Germany. E-mail: [email protected] **Universitaet Bielefeld, CeBiTec, D - 33594 Bielefeld, Germany. E-mail: [email protected] The new research field of synthetic biology is emerging from molecular biology, chemistry, biotechnology, information technology and engineering. This paper describes synthetic biology as a ‘Science of the Artificial’ and identifies structural features of engineering sciences that can be applied to this new kind of biology as opposed to traditional biology. The search for laws already in traditional biology has been difficult. In Synthetic Biology, action and application stand in the foreground and laws increas- ingly lose ground as a meaningful concept. Introduction Historically, biology has been a field based almost entirely on observation and analysis on various levels of description, concentrating on molecules, supramolecular entities, cells or multicellular organisms. But although there are – especially in evolutionary biology – mathematical models such as Mendel’s ‘laws’, Fisher’s sex ratio model or the Hardy-Weinberg equilibrium, at each level obstacles to the conclusion that biology has distinctive laws can be found (Ref. 1, p. 62). To date, ‘identifying biological laws is not easy’, as is stated in an introductory text to the philosophy of biology (Ref.