Evaluating a Child Who Has a Limp
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Statin Myopathy: a Common Dilemma Not Reflected in Clinical Trials
REVIEW CME EDUCATIONAL OBJECTIVE: Readers will assess possible statin-induced myopathy in their patients on statins CREDIT GENARO FERNANDEZ, MD ERICA S. SPATZ, MD CHARLES JABLECKI, MD PAUL S. PHILLIPS, MD Internal Medicine Residency Program, Robert Wood Johnson Clinical Scholars Department of Neurosciences, University Director, Interventional Cardiology, The University of Utah, Salt Lake City Program, Cardiovascular Disease Fellow, of California San Diego, La Jolla Department of Cardiology, Scripps Mercy Yale University School of Medicine, New Hospital, San Diego, CA Haven, CT Statin myopathy: A common dilemma not reflected in clinical trials ■■ ABSTRACT hen a patient taking a statin complains Wof muscle aches, is he or she experiencing Although statins are remarkably effective, they are still statin-induced myopathy or some other prob- underprescribed because of concerns about muscle toxic- lem? Should statin therapy be discontinued? Statins have proven efficacy in preventing ity. We review the aspects of statin myopathy that are 1 important to the primary care physician and provide a heart attacks and death, and they are the most guide for evaluating patients on statins who present with widely prescribed drugs worldwide. Neverthe- less, they remain underused, with only 50% of muscle complaints. We outline the differential diagnosis, those who would benefit from being on a statin the risks and benefits of statin therapy in patients with receiving one.2,3 In addition, at least 25% of possible toxicity, and the subsequent treatment options. adults who start taking statins stop taking them 4 ■■ by 6 months, and up to 60% stop by 2 years. KEY POINTS Patient and physician fears about myopathy There is little consensus on the definition of statin-in- remain a key reason for stopping. -
Policy on Infant Hip Screening
Policy on Infant Hip Screening COMMITTEE ON CHIROPRACTIC PAEDIATRIC DIAGNOSTIC AND THERAPEUTIC PROCEDURES January 2020 Note: This policy is relevant to infant ages only. A policy on hip screening in the post-infantile paediatric patient will be covered separately. BACKGROUND Developmental dysplasia of the hip (DDH) is one of the most common musculoskeletal conditions of infancy.1 DDH is the result of abnormal relationship between the femoral head and the acetabulum. It can range in severity from instability to dislocation (requiring surgical intervention), with varying degrees of acetabular dysplasia in between.2–4 In Australia, there is a reported incidence of seven per 1000 live births.5 The incidence of late- detection (clinically detected DDH after 3 months of age) and diagnosis has increased from 0.22 per 1000 live births in 1988-2003 to 0.7 per 1000 in 2003-2009.6,7 SCREENING In Australia, it is recommended that General Practitioners (GP) and Maternal and Child Health Nurses (MCHN) screen for DDH by performing Ortolani, Barlow, Abduction and Allis tests, as well as observing for leg length and thigh crease asymmetry.8–11 This follows guidelines established by the American Academy of Orthopaedic Surgeons.12 Regular screening is important as early detection of DDH has better outcomes and requires less aggressive management with reduced risks: bracing and non-surgical intervention compared to potential surgical intervention for those older than 6 months of age.5 Clinical hip examination by the infants’ GP and MCHN remains the primary -
Upper Extremity
Upper Extremity Shoulder Elbow Wrist/Hand Diagnosis Left Right Diagnosis Left Right Diagnosis Left Right Adhesive capsulitis M75.02 M75.01 Anterior dislocation of radial head S53.015 [7] S53.014 [7] Boutonniere deformity of fingers M20.022 M20.021 Anterior dislocation of humerus S43.015 [7] S43.014 [7] Anterior dislocation of ulnohumeral joint S53.115 [7] S53.114 [7] Carpal Tunnel Syndrome, upper limb G56.02 G56.01 Anterior dislocation of SC joint S43.215 [7] S43.214 [7] Anterior subluxation of radial head S53.012 [7] S53.011 [7] DeQuervain tenosynovitis M65.42 M65.41 Anterior subluxation of humerus S43.012 [7] S43.011 [7] Anterior subluxation of ulnohumeral joint S53.112 [7] S53.111 [7] Dislocation of MCP joint IF S63.261 [7] S63.260 [7] Anterior subluxation of SC joint S43.212 [7] S43.211 [7] Contracture of muscle in forearm M62.432 M62.431 Dislocation of MCP joint of LF S63.267 [7] S63.266 [7] Bicipital tendinitis M75.22 M75.21 Contusion of elbow S50.02X [7] S50.01X [7] Dislocation of MCP joint of MF S63.263 [7] S63.262 [7] Bursitis M75.52 M75.51 Elbow, (recurrent) dislocation M24.422 M24.421 Dislocation of MCP joint of RF S63.265 [7] S63.264 [7] Calcific Tendinitis M75.32 M75.31 Lateral epicondylitis M77.12 M77.11 Dupuytrens M72.0 Contracture of muscle in shoulder M62.412 M62.411 Lesion of ulnar nerve, upper limb G56.22 G56.21 Mallet finger M20.012 M20.011 Contracture of muscle in upper arm M62.422 M62.421 Long head of bicep tendon strain S46.112 [7] S46.111 [7] Osteochondritis dissecans of wrist M93.232 M93.231 Primary, unilateral -
Transient Synovitis Or Septic Arthritis in Early Stage?
edicine: O M p y e c n n A e c g c r e e s s m E Emergency Medicine: Open Access Sekouris et al., Emergency Med 2014, 4:4 ISSN: 2165-7548 DOI: 10.4172/2165-7548.1000195 Short Communication Open Access Hip Pain in Children, a Diagnostic Challenge: Transient Synovitis or Septic Arthritis in Early Stage? Nick Sekouris*, Antonios Angoules, Dionysios Koukoulas and Eleni C Boutsikari Asssistant Director Orthopaedic, 'Metropolitan' Hospital, Athens, Greece *Corresponding author: Nick Sekouris, Asssistant Director Orthopaedic, 'Metropolitan' Hospital, Athens, Greece, Tel: +30 (210) 864 2202; E-mail: [email protected] Received date: April 27, 2014; Accepted date: June 13, 2014; Published date: June 17, 2014 Copyright: © 2014 Sekouris, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Short Communication symptoms, in case of SA, a destruction or dislocation of the femoral head or a widespread destruction of the femoral head and neck may be Hip pain in children is a diagnostic challenge for every practitioner visible radiographically. in emergency medicine and for any other doctor or health professional, facing this common symptom. Diagnosis may vary from Bone scintigraphy is neither sensitive nor specific enough in innocent conditions such as Transient Synovitis (TS), also mentioned distinguishing TS from SA and is not routinely used. Nevertheless, it as “irritable hip”, to hazardous for the child health diseases like Septic can diagnose multiple musculoskeletal lesions [7]. Arthritis (SA). -
Acetabular Labral Tears and Femoroacetabular Impingement
Michael J. Sileo, MD, FAAOS Sports Medicine Injuries Arthroscopic Shoulder, Knee & Hip Surgery December 7, 2018 NONE Groin and hip pain is common in athletes Especially hockey, soccer, and football 5% of all soccer injuries Renstrom et al: Br J Sports Med 1980. Complex anatomy and wide differential diagnoses that span multiple medical specialties make diagnosis difficult • Extra-articular causes: Muscle strain Snapping hip Adductor Trochanteric bursitis Iliopsoas Abductor tears Gluteus medius Compression neuropathies Hamstrings LFCN (meralgia paresthetica) Gracilis Sciatic nerve (Piriformis Avulsion injuries syndrome) Sports Hernia Ilioinguinal, Osteitis Pubis iliohypogastric, or genitofemoral nerve Intra-articular causes: Labral pathology Capsular laxity Femoroacetabular impingement Stress fracture Chondral pathology Septic arthritis Ligamentum teres injury Adhesive capsulitis Loose bodies Osteonecrosis Benign Intra-articular tumors SCFE PVNS Transient synovitis Synovial chondromatosis Soft-tissue injuries such as muscle strains and contusions are the most common causes of hip pain in the athlete It is important to be aware and suspicious of intra- articular causes of hip pain Up to 60% of athletes undergoing arthroscopy are initially misdiagnosed Delay to diagnosis is typically 7 months Labral pathology may not be diagnosed for up to 21 months Byrd et al: Clin Sports Med 2001. Burnett et al: JBJS 2006. Nature of discomfort Mechanical symptoms Stiffness Weakness Instability Location of discomfort -
SUPPLEMENTARY MATERIAL Supplementary 1. International
SUPPLEMENTARY MATERIAL Supplementary 1. International Myositis Classification Criteria Project Steering Committee Supplementary 2. Pilot study Supplementary 3. International Myositis Classification Criteria Project questionnaire Supplementary 4. Glossary and definitions for the International Myositis Classification Criteria Project questionnaire Supplementary 5. Adult comparator cases in the International Myositis Classification Criteria Project dataset Supplementary 6. Juvenile comparator cases in the International Myositis Classification Criteria Project dataset Supplementary 7. Validation cohort from the Euromyositis register Supplementary 8. Validation cohort from the Juvenile dermatomyositis cohort biomarker study and repository (UK and Ireland) 1 Supplementary 1. International Myositis Classification Criteria Project Steering Committee Name Affiliation Lars Alfredsson Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Anthony A Amato Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA Richard J Barohn Department of Neurology, University of Kansas Medical Center, Kansas City, USA Matteo Bottai Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Matthew H Liang Division of Rheumatology, Immunology and Allergy, Brigham and Women´s Hospital, Boston, USA Ingrid E Lundberg (Project Director) Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden Frederick W Miller Environmental -
Differential Diagnosis of Juvenile Idiopathic Arthritis
pISSN: 2093-940X, eISSN: 2233-4718 Journal of Rheumatic Diseases Vol. 24, No. 3, June, 2017 https://doi.org/10.4078/jrd.2017.24.3.131 Review Article Differential Diagnosis of Juvenile Idiopathic Arthritis Young Dae Kim1, Alan V Job2, Woojin Cho2,3 1Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea, 2Department of Orthopaedic Surgery, Albert Einstein College of Medicine, 3Department of Orthopaedic Surgery, Montefiore Medical Center, New York, USA Juvenile idiopathic arthritis (JIA) is a broad spectrum of disease defined by the presence of arthritis of unknown etiology, lasting more than six weeks duration, and occurring in children less than 16 years of age. JIA encompasses several disease categories, each with distinct clinical manifestations, laboratory findings, genetic backgrounds, and pathogenesis. JIA is classified into sev- en subtypes by the International League of Associations for Rheumatology: systemic, oligoarticular, polyarticular with and with- out rheumatoid factor, enthesitis-related arthritis, psoriatic arthritis, and undifferentiated arthritis. Diagnosis of the precise sub- type is an important requirement for management and research. JIA is a common chronic rheumatic disease in children and is an important cause of acute and chronic disability. Arthritis or arthritis-like symptoms may be present in many other conditions. Therefore, it is important to consider differential diagnoses for JIA that include infections, other connective tissue diseases, and malignancies. Leukemia and septic arthritis are the most important diseases that can be mistaken for JIA. The aim of this review is to provide a summary of the subtypes and differential diagnoses of JIA. (J Rheum Dis 2017;24:131-137) Key Words. -
Musculoskeletal Clinical Vignettes a Case Based Text
Leading the world to better health MUSCULOSKELETAL CLINICAL VIGNETTES A CASE BASED TEXT Department of Orthopaedic Surgery, RCSI Department of General Practice, RCSI Department of Rheumatology, Beaumont Hospital O’Byrne J, Downey R, Feeley R, Kelly M, Tiedt L, O’Byrne J, Murphy M, Stuart E, Kearns G. (2019) Musculoskeletal clinical vignettes: a case based text. Dublin, Ireland: RCSI. ISBN: 978-0-9926911-8-9 Image attribution: istock.com/mashuk CC Licence by NC-SA MUSCULOSKELETAL CLINICAL VIGNETTES Incorporating history, examination, investigations and management of commonly presenting musculoskeletal conditions 1131 Department of Orthopaedic Surgery, RCSI Prof. John O'Byrne Department of Orthopaedic Surgery, RCSI Dr. Richie Downey Prof. John O'Byrne Mr. Iain Feeley Dr. Richie Downey Dr. Martin Kelly Mr. Iain Feeley Dr. Lauren Tiedt Dr. Martin Kelly Department of General Practice, RCSI Dr. Lauren Tiedt Dr. Mark Murphy Department of General Practice, RCSI Dr Ellen Stuart Dr. Mark Murphy Department of Rheumatology, Beaumont Hospital Dr Ellen Stuart Dr Grainne Kearns Department of Rheumatology, Beaumont Hospital Dr Grainne Kearns 2 2 Department of Orthopaedic Surgery, RCSI Prof. John O'Byrne Department of Orthopaedic Surgery, RCSI Dr. Richie Downey TABLE OF CONTENTS Prof. John O'Byrne Mr. Iain Feeley Introduction ............................................................. 5 Dr. Richie Downey Dr. Martin Kelly General guidelines for musculoskeletal physical Mr. Iain Feeley examination of all joints .................................................. 6 Dr. Lauren Tiedt Dr. Martin Kelly Upper limb ............................................................. 10 Department of General Practice, RCSI Example of an upper limb joint examination ................. 11 Dr. Lauren Tiedt Shoulder osteoarthritis ................................................. 13 Dr. Mark Murphy Adhesive capsulitis (frozen shoulder) ............................ 16 Department of General Practice, RCSI Dr Ellen Stuart Shoulder rotator cuff pathology ................................... -
Evaluation of the Limping Child
Current Concept Review Evaluation of the Limping Child Jessica Burns, MD, MPH; Scott Mubarak, MD Rady Children’s Hospital, San Diego, CA Abstract: Prompt evaluation of a younger child (age <5) with gait disturbance or refusal to walk is necessary to distinguish orthopedic urgency (trauma or infection) from relatively benign processes and chronic problems such as arthritis. Physical examination should include evaluation of gait, supine and simulated prone hip examination (on the parent’s lap to keep the child comfortable), and the crawl test. There are six radiographic views of the lower extremities that can assist in the diagnosis. In conjunction with the detailed history, a thorough physical exam, and radiographs from the orthopedic provider can determine the need for laboratory tests and other imaging. Key Concepts: • Evaluation of the limping child begins with a thorough history. • Physical examination of the limping child can be optimized by utilizing the parent to hold the child while the examiner moves the extremities and checks the back. • Six screening radiographs can be obtained to assist in making the correct diagnosis. • Laboratory analysis and magnetic resonance imaging can be obtained if the diagnosis remains elusive. Introduction Evaluation of gait disturbance in the younger child is an symptoms. Utilizing the parent in the physical important skill for the pediatric orthopedic surgeon. examination can help elicit a more detailed examination Although the true incidence is unknown, it is estimated of the child. Focused radiographs can then be utilized to that there are 1.8 per thousand children that will present support a suspected diagnosis. From there, the need for to the pediatric emergency department with complaint of laboratory analysis and further advanced imaging can be gait disturbance. -
Joint Pains UHL Childrens Hospital Guideline
LRI Children’s Hospital Joint Pains in Children Staff relevant to: Children’s Medical and Nursing Staff working within UHL Children’s Hospital Team approval date: March 2019 Version: 2 Revision due: March 2022 Written by: Dr A Sridhar, Consultant Paediatrician/Paediatric Rheumatology Trust Ref: C89/2016 1. Introduction and Who Guideline applies to THIS IS AN AREA WHERE CLINICAL ASSESSMENT IS USUALLY MUCH MORE IMPORTANT THAN “ROUTINE INVESTIGATIONS” SINGLE PAINFUL JOINT The most important diagnosis to consider is SEPTIC ARTHRITIS Can occur: In Any Joint All Age Groups May be co-existing osteomyelitis (particularly in very young) Related documents: Management of the limping child UHL - C13/2016 Septic Arthritis UHL – B47/2017 Differential diagnosis: 1. History of Injury: Traumatic, Acute Joint bleed (May be the first presentation of Haemophilia or other bleeding disorder) - Haemarthroses 2. Significant Fever and Pain: Septic arthritis or Osteomyelitis 3. Recent Viral illness, diarrhoea, Tonsillitis: Reactive Arthritis- 7-14 days after the illness, Fever may not be present 4. History of IBD: Usually monoarthritis of large joints reflects activity 5. Vascultic Rash: HSP or other forms of vasculitis Page 1 of 6 Title: Joint Pains in Children V:2 Approved by Children’s Clinical Practice Group: March 2019 Trust Ref: C89/2016 Next Review: March 2022 NB: Paper copies of this document may not be most recent version. The definitive version is held in the Trust Policy and Guideline Library. 6. Recent Drug ingestion: Serum sickness often associated with Urticarial rash 7. Bone pain, Lymphadenopathy, Hepato-splenomegaly: Leukemia, Lymphoma, Neuroblastoma, bone tumour (h/o nocturnal bone pain) 8. -
EM Guidemap - Myopathy and Myoglobulinuria
myopathy EM guidemap - Myopathy and myoglobulinuria Click on any of the headings or subheadings to rapidly navigate to the relevant section of the guidemap Introduction General principles ● endocrine myopathy ● toxic myopathy ● periodic paralyses ● myoglobinuria Introduction - this short guidemap supplements the neuromuscular weakness guidemap and offers the reader supplementary information on myopathies, and a short section on myoglobulinuria - this guidemap only consists of a few brief checklists of "causes of the different types of myopathy" that an emergency physician may encounter in clinical practice when dealing with a patient with acute/subacute muscular weakness General principles - a myopathy is suggested when generalized muscle weakness involves large proximal muscle groups, especially around the shoulder and proximal girdle, and when the diffuse muscle weakness is associated with normal tendon reflexes and no sensory findings - a simple classification of myopathy:- Hereditary ● muscular dystrophies ● congenital myopathies http://www.homestead.com/emguidemaps/files/myopathy.html (1 of 13)8/20/2004 5:14:27 PM myopathy ● myotonias ● channelopathies (periodic paralysis syndromes) ● metabolic myopathies ● mitochondrial myopathies Acquired ● inflammatory myopathy ● endocrine myopathies ● drug-induced/toxic myopathies ● myopathy associated with systemic illness - a myopathy can present with fixed weakness (muscular dystrophy, inflammatory myopathy) or episodic weakness (periodic paralysis due to a channelopathy, metabolic myopathy -
Hip Osteoarthritis Information
Bòrd SSN nan Eilean Siar NHS Western Isles Physiotherapy Department Hip Osteoarthritis An Information Guide for Patients and Carers Page 1 Contents Section 1: What is osteoarthritis? 3 Contributing factors to osteoarthritis Section 2: Diagnosis and symptoms 5 Symptoms Diagnosis Flare up of symptoms Section 3: Gentle hip exercises for flare ups 7 Section 4: Living with osteoarthritis 8 How with osteoarthritis affect me? What you can do to help yourself Section 5: Range of movement exercises 9 Section 6: Strengthening exercises 10 Other forms of exercise Section 7: Other treatments 13 Living with osteoarthritis Surgery Section 8: Local groups and activities 14 Page 2 What is osteoarthritis? This booklet is designed to give you some useful information following your diagnosis of osteoarthritis. Osteoarthritis is a very common condition which can affect any joint causing pain, and stiffness. It’s most likely to affect the joints that bear most of our weight, such as the hips, as they have to take extreme stresses, twists and turns, therefore osteoarthritis of the hip is very common and can affect either one or both hips. A normal joint A joint with mild osteoarthritis In a healthy joint, a coating of smooth and slippery tissue, called cartilage, covers the surface of the bones and helps the bones to move freely against each other. When a joint develops osteoarthritis, the bones lose their smooth surfaces and they become rougher and the cartilage thins. The repair process of the cartilage is sometimes not sufficient as we age. Almost all of us will develop osteoarthritis in some of our joints as we get older, though we may not even be aware of it.