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Treatment of Otomycosis: a Comparative Study Using Miconazole Cream with Clotrimazole Otic Drops

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Treatment of Otomycosis: a Comparative Study Using Miconazole Cream with Clotrimazole Otic Drops Treatment of Otomycosis: A Comparative Study Using Miconazole Cream with Clotrimazole Otic Drops Sufian Alnawaiseh MD*, Osama Almomani MD*, Salman Alassaf MD*, Amjad Elessis MD*, Nabeel Shawakfeh MD*, Khalid Altubeshi MD*, Raed Akaileh MD* ABSTRACT Objective: This study was conducted to compare the use of two different antifungal agents from the azoles family; Miconazole cream applied topically on the skin of the external canal and tympanic membrane and Clotrimazole otic drops. Methods: Ninety patients aged (12-72) years who presented with otomycosis at Prince Hashim Hospital in Zarka between October 2007 to June 2009 were enrolled in this study. Patients were divided into two groups, group A (48 patients): patients were treated by toileting and application of Miconazole cream, group B (42 patients): patients were treated by toileting and using Clotrimazole 1% (otozol) otic drops. Patients followed after one and two weeks. One way ANOVA test was used to calculate the significant differences at P<0.05 between the means of the study treatment groups Results: Patients in group A (Miconazole) showed a better response to treatment in comparison to patients in group B (Clotrimazole drops). Conclusion: Although the two treatment regimens showed no statistically significant difference due to the small number of cases, Micanazole cream after toileting is a better choice due to its lower cost and better compliance Key words: Clotrimazole (otozol), Miconazole, Ootomycosis, Toileting. JRMS September 2011; 18(3): 34-37 Introduction postulated that indiscriminate use of topical ear drops has increased the incidence of fungal Otomycosis, also known as fungal otitis externa, (3) has been used to describe a fungal infection of the infections of the external auditory canal. external auditory canal and its associated The fungi that produce otomycosis are generally complications, sometimes involving the middle saprophytic fungi species that abound in nature and ear.(1) It is one of the common conditions that form a part of the commensal flora of healthy encountered in a general otolaryngology clinic external auditory canal. These fungi are commonly setting and its prevalence has been quoted to be as Aspergillus and Candida. Aspergillus niger is high as 9% among patients who present with signs usually the predominant agent although A.flavus, and symptoms of otitis externa.(2) There is an A.fumigatus, A. terreus (filamentous fungi), Candida albicans and C. parapsilosis (yeast-like alarming increase in its incidence due to the wide (4) spread use of broad-spectrum antibiotics, steroids fungi) are also common. and other chemotherapeutic agents. It has been Fungal infections occur more frequently in tropical *From the Department of ENT, King Hussein Medical Center, (KHMC), Amman-Jordan Correspondence should be addressed to Dr. S. Alnawaiseh, P.O. Box 396 Amman 11732 Jordan, E-mail: [email protected] Manuscript received December 5, 2009. Accepted July 22, 2010 34 JOURNAL OF THE ROYAL MEDICAL SERVICES Vol. 18 No. 3 September 2011 or subtropical climates or during periods of intense characteristic findings on otoscopic examination. heat and humidity. It is common in patients who The classical appearance looked like a grayish white have undergone open cavity mastoidectomy and plug resembling wet blotting paper, yellowish those who wear hearing aids.(5) Jones (1965) spores, a whitish, furry structure, or blackish spores reported that patients who had recurrent attacks of covering the canal and sometimes the tympanic otitis externa had primary fungal infections with a membrane also. super-added bacterial pathogen, the latter cleared up All the affected ears were thoroughly cleaned with with treatment but the fungal infection was not suction under magnified otoscopy. After complete eradicated, causing relapses.(6) removal of debris and the fungal mass, cultures are The clinical symptoms most frequently observed in not routinely obtained because there is generally a these patients were burning sensation in the ear, rapid response to the treatment. All the patients were pruritis, sensation of fullness in the ear, otalgia, instructed to avoid water entering their ears and they otorrhoea, loss of hearing, tinnitus and severe offered to choose between two topical treatment headaches.(7) regimens; Group A 48 patients (53.3%) were treated There are four main classes of drugs for the by the Micanazole cream which was applied in the treatment of fungal infections: polyenes, triazoles, clinic directly onto the involved external auditory nucleoside analogues, and echinocandins. The canal after toileting. Application is facilitated with a polyenes family includes Amphoterecin B and small syringe (3 cc) and an 18 gauge IV catheter. Nystatin. The Triazoles family, better known as The micanazole cream is held in place by its innate azoles includes: Fluconazole, Clotrimazole and viscosity and the shape of the external auditory Miconazole. The mechanism of action of polyenes canal. The ear canal is inspected 1 week later and and azole families involves an essential chemical residual cream is removed and a second application component called ergosterol found in the fungal cell is used for persistent disease, all cases were membrane. The drug binds to ergosterol leading to followed up after 2 weeks. Group B 42 patients were its death.(1) treated by topical application of Clotrimazole 1% Different studies in the literature compared the (Otozol) otic drops, 2-3 drops three times a day in efficacy of clotrimazole and Miconazole otic the affected ear. All of them were followed up after, solutions in the treatment of otomycosis, some one and two weeks. indicating equal efficacy while other studies were in favor of Clotrimazole, but none of the studies Patient’s response to treatment was divided as compared the efficacy of Clotrimazole otic drops follows: with miconazole cream (3, 6, 8, and 9). Good response: when the external auditory canal This study was conducted to compare the use of and tympanic membrane were dry with no remnant two deferent antifungal agents from the azoles of secretions. family; Miconazole cream applied topically on the Moderate response: when there was minimal skin of the external canal and tympanic membrane secretions (not dry). and Clotrimazole otic drops. No response: still full of secretions. One way ANOVA test was used to calculate the Methods significant differences at P<0.05 between the means This comparative study was conducted at Prince of the study treatment groups Hashim Hospital in Zarka from October 2007 to June 2009, patients of ages (12-72) years who Results presented with otomycosis were enrolled in the Ninety-eight patients were initially enrolled in the study. study, aged from 12-72 years (mean age 42.3). Fifty three patients in group A and 45 patients in group B. Exclusion criteria include: There was no statistical difference in age or gender - Otitis externa with external auditory meatus between the two groups. stenosis. Eight patients were excluded from the study, 3 - Chronic discharging ear. presented with severe otitis externa, 2 had past - Previous ear surgery. history of discharging ear and 3 patients had The criteria of clinical diagnosis were history and previous ear surgery. JOURNAL OF THE ROYAL MEDICAL SERVICES 35 Vol. 18 No. 3 September 2011 Table I. Presenting complaint at the time of diagnosis Complaint Number % Otalgia 50 55 Aural fullness 35 38.8 Itching 31 34.4 Otorrhea 26 28.8 Hearing loss 20 22.2 Table II. Treatment response after one week Treatment response Group A Group B P value Toileting+miconazole (48) Toileting+otozol E/D (42) No % No % Good 35 72.9 23 54.7 0.140 Moderate 8 16.6 12 28.5 No 5 10.4 7 16.6 Table III. Treatment response after 2 weeks Treatment response Group A Group A P value Toileting+miconazole (48) Toileting+miconazole (48) No % No % Good 40 83.3 30 1.4 Moderate 6 12.5 9 21.4 0.075 No 2 4.1 3 7.1 Total number of patients found to be eligible in our agents.(2) In Jordan, particularly at the Royal study was ninety, 48 patients in group A (toileting Medical Services, we usually treat otomycosis by and Miconazole cream). Forty two patients in group mechanical cleansing of the canal followed by local B (toileting and Clotrimazole otic drops). application of antifungal cream or prescribing The most common presenting complaint at time of antifungal otic drops to the patient and follow them diagnosis was otalgia, followed by aural fullness, every week till recovery. In our study, we compared itching, and otorrhoea and hearing loss. (Table I) two modalities of otomycosis treatment, cleaning of After one week, 35 patients from group A showed visible fungal elements in the external auditory good response, 8 patients moderate response and 5 canal by suction (toileting) and application of patients still with no response, while 23 patients Miconazole cream directly onto the involved from group B found to have good response, 12 with external auditory canal skin at the clinic by ENT moderate response and 7 with no response. The doctor and toileting followed by use of otozol ear results were statistically not significant with a drops by the patients. significance value 0.14, which is less than the In our study application of miconazole cream after significance level of 0.05. (Table II) toileting the external auditory canal gave the best After two weeks, 40 patients in group A found to result as 40 patients out of 48 (83%) showed have good response, 6 had moderate response and complete recovery after two weeks. Although using only 2 patients had no response. In group B, 30 clotrimazole ear drops after toileting gave good patients showed good response, 9 had moderate response but this modality is still less effective than response and 3 patients with no response. The application of miconazole cream after both one results were statistically not significant with a week and two weeks, statistically the results were significance value 0.075.
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