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ENGINEERING BIOLOGY at IMPERIAL COLLEGE LONDON HISTORY Professor Richard Kitney: Co-Director of the Centre for Synthetic Biology and Innovation

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ENGINEERING BIOLOGY at IMPERIAL COLLEGE LONDON HISTORY Professor Richard Kitney: Co-Director of the Centre for Synthetic Biology and Innovation SYNTHETIC BIOLOGY – ENGINEERING BIOLOGY AT IMPERIAL COLLEGE LONDON HISTORY Professor Richard Kitney: Co-Director of the Centre for Synthetic Biology and Innovation Professor Paul Freemont: Co-Director of the Centre for Synthetic Biology and Innovation Preliminary research in synthetic biology started at Imperial College London in 2004. In 2005 Professors Richard Kitney and Paul Freemont were awarded an internal grant by Imperial to establish a laboratory for synthetic biology research. In addition to Kitney and Freemont, this PhD students - from the Life Sciences, Many international observers now comprised a handful of PhD students - Engineering and the Natural Sciences consider CSynBI to be one of the leading plus the part-time assistance of Kirsten departments. They were supported by international centres for research in Jensen as the laboratory manager. The the Science and Innovation Award and synthetic biology, indeed its international work of the laboratory, with limited funds, subsequently by a range of other grants influence is considerable. CSynBI has grew steadily until 2008. It was during made possible by the existence of CSynBI. been proud to welcome international this year that the Research Councils Within Imperial there are around another delegations from countries such as launched a call for synthetic biology as 40 scientists and engineers working France, China and Singapore (including part of the programme for Science and on projects associated with CSynBI the Singaporean Economic Development Innovation Centres aimed at building demonstrating its collaborative reach. Board) and assist them in their synthetic academic capacity. Imperial’s application In addition, Professor Nik Rose and biology policy development. was successful and in the spring of collegues from the Department of Social Members of the Centre (principally 2009 the EPSRC Centre for Synthetic Science, Health and Medicine, at King’s Professors Kitney and Freemont) have Biology and Innovation (CSynBI) was College London study the responsible been heavily involved in the development established. CSynBI’s strategy is one of innovation issues (i.e. societal, ethical and of synthetic biology strategy for the UK. applying engineering to biology by way environmental considerations) relating to of systematic design. This involves the synthetic biology. application of the engineering principles The Centre’s collaborative reach is now of modularity, standardisation and international and it has strong links with characterisation - via the development the United States, including Stanford of platform technology - to a range of University and UC Berkeley - as well as applications. being a key member of European grants. CSynBI’s capacity has continued to It has significant ongoing collaboration build and expand and it now comprises with NTU and NUS in Singapore. 10 PIs and around another 60 researchers - consisting of Postdoctoral Fellows and In 2008 Professor Kitney chaired a published in July 2012. Both Kitney and written agreement between the groups. In Royal Academy of Engineering inquiry into Freemont made significant contributions the spring of 2012 the Flowers Consortium synthetic biology, which was published in to both the development of the strategy was awarded a significant grant by EPSRC May 2009. and the writing of the Roadmap. Again, for the specific purpose of developing this document has been influential platform technology (sometimes called Professor Freemont was also a key internationally. foundational technology) for synthetic member of the inquiry. The report of biology. the inquiry has been, and remains, Also in 2011, CSynBI organised a two- influential in the development of day workshop at Imperial College for the This project has been running synthetic biology strategy in many groups involved in synthetic biology at for two and a half years and last countries. In the autumn of 2011 the Rt the Universities of Cambridge, Edinburgh, summer underwent a full review by its Hon David Willetts MP, the then Minister Newcastle and Kings College London. international advisory board - which of State for Universities and Research, The aim was to broaden activities to comprises leading synthetic biologists organised a roundtable discussion at encompass the additional strengths of from the United States and Europe. As the UK Government’s Department of these universities in the area of synthetic a result of the strength of the research Business Innovation and Skills to which biology. The plan was to establish a within the Flowers Consortium, CSynBI both Kitney and Freemont were invited. consortium of research activity. was invited to become a member of One of the results of the roundtable SynBERC. There will be a Flowers Because the workshop was held in discussion was the establishment of a Consortium session at the 2015 SynBERC the Flowers Building at Imperial, the working group to develop a roadmap for meeting, in Berkeley, USA. consortium was called the Flowers synthetic biology for the UK – this was Consortium and was established by a SYNTHETIC BIOLOGY HUB encompassing: CSynBI The Flowers Consortium SynbiCITE The Foundry Frontiers Engineering Synthetic biology at Imperial College London continues to grow and CSynBI is now a leading centre of excellence with a network of research teams and innovation and knowledge centres. CSynBI is proud of the scale of its activities, which range from education to world-leading research to industrial applications. It influences strategy and spearheads engineering in synthetic biology. It is leading the way in automating the production of interchangeable genetic elements. Development of these elements is critical if we are to scale up synthetic biology processes such that we can make a real impact in the big challenges facing society. CSYNBI.. A programme of research, training, development and dissemination has, PRINCIPLE INVESTIGATORS.. The Centre for Synthetic Biology and through upstream involvement from IN THE CENTRE.. Innovation (CSynBI) is the academic arm the very outset of CSynBI, enhanced of the Hub, which is led by Professors capabilities to understand the ways that Professor Richard Kitney, Richard Kitney and Paul Freemont. developments in synthetic biology impact Co-Director: BioLogic, biosensors, It specialises in the research and and shape the world around us, and modelling development of foundational tools continues to facilitate the development Professor Paul Freemont, for synthetic biology and the use of of informed dialogue and an appropriate Co-Director: Biosensors, part these tools in new applications to solve regulatory and policy regime. CSynBI also characterisation problems for example in industry and works with key social scientists from the Professor Nik Rose, healthcare. CSynBI is committed to University of Edinburgh on responsible Kings College London: Ethical, legal responsible research and innovation research and innovation. and societal issues (RRI) and is therefore comprised of scientists and engineers at Imperial Academics in CSynBI were the first Dr Tom Ellis: College London and societal and ethical to design and implement synthetic DNA assembly, gene networks and issue researchers from the Department biology courses in the UK (and possibly modules of Social Science, Health and Medicine at in Europe). Consequently, researchers Dr Geoff Baldwin: King’s College London. at CSynBI play a large role in teaching Directed protein evolution synthetic biology at Imperial College Dr John Heap: The scientific research goals of CSynBI through undergraduate and postgraduate are to establish an engineering framework Development of foundational courses. Synthetic Biology is a technical biological technologies for the design and optimisation of new option for year 3 BEng and MEng biological parts, devices and systems, undergraduate students following both Dr Karen Polizzi: Biosensors for bioprocessing and, in tandem, to apply synthetic the Electrical and Mechanical pathways of biology to develop a wide range of the Biomedical Engineering programmes. Dr Clare Marris, novel biotechnologies. Led by Professor It is also available to students working Kings College London: Ethical, legal Nik Rose from Kings College London, towards a BSc in Biochemistry or Biology. and societal issues CSynBI is also addressing issues of At the postgraduate level CSynBI is proud Dr Guy-Bart Stan: public engagement and trust, as well as to offer an MRes in Systems and Synthetic Biomodelling analysis and control engaging with the central concerns of Biology and many PhD opportunities. policy and regulation in this novel and rapidly developing area. www.imperial.ac.uk/syntheticbiology THE FLOWERS CONSORTIUM.. Now half way through, the Flowers Project has achieved a number of The Flowers Consortium is made up important goals. of representatives from the Universities of Cambridge, Newcastle, Edinburgh The community now has the ability to and Kings College London. Professor Nik undertake multi-institutional research Rose and Dr Clare Marris at Kings College collaboration across the Flowers London, and Drs Jane Calvert, Emma Frow Consortium, enabling the cohesive and Professor Joyce Tait at the University development of platform technologies of Edinburgh, specialise in researching and the integration of tools and the ethical and societal issues associated methodologies which will impact with synthetic biology as part of the the ability to undertake systematic Flowers Consortium’s mission. design. The fundamental aim of the Flowers
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