DOCSLIB.ORG

Nanobiotix Appoints New Chief Medical Officer As The

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Nanobiotix Appoints New Chief Medical Officer As The NANOBIOTIX APPOINTS NEW CHIEF MEDICAL OFFICER AS THE COMPANY EVOLVES AFTER ACHIEVEMENT OF EUROPEAN MARKET APPROVAL • Biopharmaceutical veteran Edwina Baskin-Bey, M.D., joins Nanobiotix as its new Chief Medical Officer (CMO) • Dr. Baskin-Bey will leverage her expertise in medical strategy and late-stage clinical development to help accelerate the company’s strategic objectives • Dr. Baskin-Bey succeeds Elsa Borghi, M.D., who will remain focused on the early development of innovative products at Nanobiotix “Dr. Baskin-Bey has built an impressive career and she is joining us at a critical time. As we advance development of NBTXR3 in multiple solid tumor indications and in combination with checkpoint inhibitors, Dr. Baskin-Bey’s breadth and depth of experience align perfectly with our strategic leadership needs. To date, Dr. Borghi has been instrumental in bringing our lead product to European market approval. I am excited that she will continue to create and develop new innovative approaches for Nanobiotix.” – Laurent Levy, CEO of Nanobiotix “It is an honor and a privilege to join Nanobiotix. I am thrilled by the opportunity to lead a dedicated team that operates on the cutting edge of nanophysics to develop unique treatment solutions and improve patient outcomes. My experience in global oncology product development, surgery and radiation should serve to help us grow and to accelerate our global clinical programs.” – Dr. Edwina Baskin-Bey, CMO of Nanobiotix Paris, France and Cambridge, Massachusetts, USA, June 4, 2019 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced it has appointed Edwina Baskin-Bey, M.D. as its new CMO. Dr. Baskin-Bey brings over 18 years of oncology clinical development and basic science experience in academia and industry, most recently serving as CMO of North Carolina-based oncology start-up, Innocrin Pharmaceuticals. As a member of the Executive Team at Innocrin, Dr. Baskin-Bey led development and implementation of the overall clinical and corporate strategy from phase I to phase III. She was responsible for the Medical, Regulatory, Pharmacovigilance, Clinical Operations, Biostatistics, and Data Management functions. Dr. Baskin-Bey joined Innocrin from Janssen Oncology of Johnson & Johnson, where she was charged with leading both early- and late-stage oncology global development programs for in-licensed products from Aragon and Tesaro, apalutamide and niraparib. Previously, she worked for more than six years at Astellas Pharma. At Astellas, BV, Netherlands Headquarters, Dr. Baskin-Bey, was responsible for several early-stage oncology programs, most notably, she co-led with the alliance partner, Medivation, the global development strategy for the in-licensed product enzalutamide, leading to FDA approval, EMA approval, and label expansions. Also while at Astellas, she served at the UK Headquarters as head of European Medical Affairs, where she was responsible for the launch of enzalutamide in Europe. Dr. Baskin-Bey currently serves as an independent board member for Catalyst Clinical Research, LLC, in North Carolina. Dr. Baskin-Bey obtained her bachelor’s degree from Hunter College in New York, and earned her medical degree at Mount Sinai/New York University (NYU) School of Medicine. She trained in general surgery and oncology for seven years at The Mayo Clinic in Rochester, MN, and in basic science research principles at the National Institute of Health (NIH). Dr. Baskin-Bey succeeds accomplished Nanobiotix CMO, Elsa Borghi, M.D. Dr. Borghi will remain with the company in a key leadership role focused on early development and innovation. -Ends- 1 About NANOBIOTIX: www.nanobiotix.com Incorporated in 2003, Nanobiotix is a leading, clinical-stage nanomedicine company pioneering new approaches to significantly change patient outcomes by bringing nanophysics to the heart of the cell. The Nanobiotix philosophy is rooted in designing pioneering, physical-based approaches to bring highly effective and generalized solutions to address unmet medical needs and challenges. Nanobiotix’s first-in-class, proprietary lead technology, NBTXR3, aims to expand radiotherapy benefits for millions of cancer patients. Nanobiotix’s Immuno-Oncology program has the potential to bring a new dimension to cancer immunotherapies. Nanobiotix is listed on the regulated market of Euronext in Paris (Euronext: NANO / ISIN: FR0011341205; Bloomberg: NANO: FP). The Company’s headquarters are in Paris, France, with a U.S. affiliate in Cambridge, MA, and European affiliates in Spain and Germany. Contact Nanobiotix Communications Department Investor Relations Department +33 (0)1 40 26 07 55 +33 (0)1 79 97 29 99 +1 (617) 852-4835 +1 (646) 241-4400 [email protected] [email protected] Media relations France - Springbok Consultants United States – RooneyPartners Marina Rosoff Marion Janic +33 (0)6 71 58 00 34 +1 (212) 223-4017 [email protected] [email protected] Disclaimer This press release contains certain forward-looking statements concerning Nanobiotix and its business, including its prospects and product candidate development. Such forward-looking statements are based on assumptions that Nanobiotix considers to be reasonable. However, there can be no assurance that the estimates contained in such forward-looking statements will be verified, which estimates are subject to numerous risks including the risks set forth in the reference document of Nanobiotix registered with the French Financial Markets Authority (Autorité des Marchés Financiers) under number R.19-018 on April 30, 2019 (a copy of which is available on www.nanobiotix.com) and to the development of economic conditions, financial markets and the markets in which Nanobiotix operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Nanobiotix or not currently considered material by Nanobiotix. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Nanobiotix to be materially different from such forward-looking statements. 2 .
Load more

Recommended publications
  • Priming the Body to Receive the Therapeutic Agent to Redefine
    www.nature.com/scientificreports OPEN Priming the body to receive the therapeutic agent to redefne treatment beneft/risk profle Received: 24 October 2017 Matthieu Germain, Marie-Edith Meyre, Laurence Poul, Marion Paolini, Céline Berjaud, Francis Accepted: 6 March 2018 Mpambani, Maxime Bergere, Laurent Levy & Agnès Pottier Published: xx xx xxxx Many therapeutic agents ofer a low useful dose (dose responsible for efcacy)/useless dose (dose eliminated or responsible for toxicity) ratio, mainly due to the fact that therapeutic agents must ensure in one single object all the functions required to deliver the treatment, which leads to compromises in their physico-chemical design. Here we introduce the concept of priming the body to receive the treatment by uncorrelating these functions into two distinct objects sequentially administered: a nanoprimer occupying transiently the main pathway responsible for therapeutic agent limited beneft/risk ratio followed by the therapeutic agent. The concept was evaluated for diferent nature of therapeutic agents: For nanomedicines we designed a liposomal nanoprimer presenting preferential hepatic accumulation without sign of acute toxicity. This nanoprimer was able to increase the blood bioavailability of nanomedicine correlated with a lower hepatic accumulation. Finally this nanoprimer markedly enhanced anti-tumor efcacy of irinotecan loaded liposomes in the HT-29 tumor model when compared to the nanomedicine alone. Then, for small molecules we demonstrated the ability of a cytochrome inhibitor loaded nanoprimer
    [Show full text]
  • Laurent Levy, CEO, Increases Stake in Nanobiotix's Capital
    Laurent Levy, CEO, increases stake in Nanobiotix’s capital • Exercising 160,000 BSPCE 2012-1 financed by own funds • Investment of EUR 960,000 to support Nanobiotix’s development • Upward crossing of 5% voting rights threshold Paris, France, and Cambridge, Massachusetts (USA) April 25, 2019 – NANOBIOTIX (Euronext : NANO – ISIN : FR0011341205 – the “Company”), a clinical-stage nanomedicine company pioneering new approaches in the treatment of cancer, announces Laurent Levy’s strengthening position in the Company’s share capital through the exercise of founders’ warrants (bons de souscription de parts de créateur d’entreprise or BSPCE2012-1) granted in 2012, and which exercise period expires on April 25, 2019. In this context, Laurent Levy subscribed to 160,000 new shares through the exercise of 160,000 BSPCE2012-1 for a total amount of EUR 960,000, bringing his ownership to 731,560 shares which represents 3.3% of capital and 5.5% of voting rights of the Company which triggers an upward threshold crossing. “This is an opportunity to participate personally to the financing of the development of Nanobiotix and to keep strengthening my commitment in this project which could potentially help millions of patients around the world.” said Laurent Levy. The Company’s Shareholders Meeting dated May 4, 2012, granted Laurent Levy 1,027,986 BSPCE2012-1, each giving the right to one new ordinary share in the Company at a strike price of EUR 6.00, which the exercise was dependent upon the Company’s share price as well as a minimum volume exchanged. The remaining balance of 867,986 BSPCE2012-1 forfeits at midnight today.
    [Show full text]
  • Nanobiotix and Thomas Jefferson University Start Research
    Nanobiotix and Thomas Jefferson University Start Research Collaboration Nanomedicine and Medical Education leaders are joining their forces in the United States to accelerate the development of NanoXray Paris, France and Philadelphia, USA – May 2 2012 - Nanobiotix, a company developing novel cancer nanotherapeutics and Thomas Jefferson University, one of Philadelphia's premier medical and health sciences universities, today announced that they have entered into a research collaboration to accelerate the development of Nanobiotix’ lead compound NBTXR3 in the US. Under the terms of the collaboration agreement, Nanobiotix will fund a 2-year preclinical research program, which will be directed by Bo Lu, MD, Professor in the Department of Radiation Oncology at Jefferson and Director of the department’s Division of Molecular Radiation Biology. The goal of the program is to study the therapeutic efficacy of NBTXR3, the lead product of Nanobiotix´ NanoXray pipeline. NBTXR3, a nanoparticle consisting of hafnium oxide crystals, aims to enhance the local destruction of the tumor mass during radiotherapy. It accumulates in the cancer cells and, upon radiation, emits huge amounts of electrons leading to the formation of free radicals. These, in turn, damage the cancer cells and cause their targeted destruction. As a result, the destructive power of standard radiation therapy is locally and selectively enhanced within the tumor cells. “For the treatment of cancer, it is important to develop ways that cause tumor cells to be more sensitive to radiation therapy,” said Dr. Bo Lu. “ We therefore are very interested in approaches that have the potential to amplify the power of the radiation dose inside the tumor without damaging the surrounding healthy cells.
    [Show full text]
  • NBTXR3) Activated by Radiation Therapy in Patients
    Author Manuscript Published OnlineFirst on October 6, 2016; DOI: 10.1158/1078-0432.CCR-16-1297 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. First Human Study Testing a New Radio Enhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas Sylvie Bonvalot1, Cécile Le Pechoux1, Thierry De Baere1, Guy Kantor1, Xavier Buy2, Eberhard Stoeckle2, Philippe Terrier1, Paul Sargos2, Jean Michel Coindre2, Nathalie Lassau1, Rafik Ait Sarkouh3, Mikaela Dimitriu3, Elsa Borghi3, Laurent Levy3, Eric Deutsch1, Jean- Charles Soria1 1Institut Gustave Roussy, Villejuif, France; 2Institut Bergonié, Bordeaux, France; 3Nanobiotix, Paris, France Running title (at the top of each page) (approx. 60 characters) Radiotherapy Plus Nanoparticles in Soft Tissue Sarcoma Prior presentations: • ASCO annual meeting, 2014: J Clin Oncol 2014;32(Suppl):5s (abstr 10563). • Connective Tissue Oncology Society annual meeting, Berlin, Germany, October 15– 18, 2014 • ESTRO forum, Barcelona, Spain, April 24–28, 2015 Financial support: This study was funded by: Nanobiotix, a nanomedicine company. 60 rue de Wattignies, 1 Downloaded from clincancerres.aacrjournals.org on September 27, 2021. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on October 6, 2016; DOI: 10.1158/1078-0432.CCR-16-1297 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 75012 PARIS Tel +33 (0) 1 40 26 04 70 www.nanobiotix.com Keywords (5 required): Soft tissue sarcoma, radiotherapy, nanoparticles, neoadjuvant treatment, radioenhancer Corresponding author: Sylvie Bonvalot, MD, PhD Department of Surgery Institut Curie, 26 rue d’Ulm, PSL Research University 75005 Paris, France Tel +33 1 44 32 45 65 Fax +33 1 40 26 04 44 [email protected] Author disclosures of conflicts of interest S Bonvalot has acted as a consultant/advisor for NANOBIOTIX and received honorarium and travel grants.
    [Show full text]
  • Nanobiotix Appoints Senior Executive from Pharmaceutical Industry, As Chief Operating Officer
    Nanobiotix appoints senior executive from pharmaceutical industry, as Chief Operating Officer Oncology industry veteran to oversee operations and product commercialization Paris, France and Cambridge, Massachusetts, USA, February 7, 2017 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer, announced today the appointment of Alain Dostie, a senior executive from the pharmaceutical industry, as its Chief Operating Officer (COO). Mr. Dostie will lead Nanobiotix’s operations, including development, manufacturing, market access and sales, for the Company’s lead product NBTXR3, which could obtain a CE Mark approval in 2017. Previously, Mr. Dostie was the Oncology General Manager at Novartis Germany. He joins Nanobiotix with over 25 years of international experience in the pharmaceutical industry, particularly in market access and oncology. Laurent Levy, CEO of Nanobiotix, commented: “We are thrilled to welcome Alain to the Nanobiotix team as our company takes major strides to enter a new phase in its development. His experience and values make Alain the perfect person to join the team to play this crucial role.” Mr. Dostie added, “Nanobiotix is at the tipping point of its value creation with the coming first Phase II/III interim readout and a potential first market approval this year. The unique, unrivaled and broadly applicable technology developed by Nanobiotix, along with the strong and enthusiastic team, attracted me to the Company. I am very excited to join the Company at such an important time and contribute to its long-term success.” Prior to joining Nanobiotix, Mr. Dostie served as the Oncology General Manager at Novartis Pharma GmbH in Germany, where he managed a team of several hundred of people and was responsible for more than $1 billion in sales.
    [Show full text]
  • Inventors and Entrepreneurs Reception
    Inventors and Entrepreneurs Reception Monday, March 25, 2013 4:00-6:00 UB Clinical and Translational Research Center University at Buffalo Inventors and Entrepreneurs Reception Welcoming Remarks Robert J. Genco Vice Provost, STOR Charles F. Zukoski Provost Satish K. Tripathi President Introduction of UB Inventors Named on U.S. Patents Visionary Innovator Awards Entrepreneurial Spirit Awards Jeffrey A. Dunbar Director, STOR Introduction of UB Technology Incubator Awards Woody Maggard Associate Vice Provost, STOR Introduction of UB Entrepreneurship Award Robert J. Genco Closing Remarks Alexander N. Cartwright Vice President for Research and Economic Development UB Inventors Named on U.S. Patents in 2012 8,110,218 Composition and Methods for Less Immunogenic Protein-Lipid Complexes UB Inventors: Sathy Balu-Iyer and Robert Straubinger, both of Pharmaceutical Sciences Collaborators: Karthik Ramani and Razvan Miclea, both formerly of Pharmaceutical Sciences 8,198,432 Porphyrin-Based Compounds for Tumor Imaging and Photodynamic Therapy UB Inventor: Munawwar Sajjad, Nuclear Medicine Collaborators: Hani Nabi , formerly of Nuclear Medicine; Amy Gryshuk, Allan Oseroff, Suresh Pandey, Ravindra K. Pandey, all from Roswell Park Cancer Institute 8,088,768 Protein Kinase and Phosphatase Inhibitors UB Inventor: David G. Hangauer, Chemistry Collaborators: Moustafa El-Araby and Karen Milkiewicz, formerly of Chemistry 8,142,716 Method of Altering a Fluid-Borne Contaminant UB Inventors: James Felske, Chemistry; James F. Garvey, John Lordi, and Joseph
    [Show full text]
  • Nanomedicine.Pdf
    EUROPEAN SCIENCE Marine FOUNDATION Board Nanomedicine An ESF – European Medical Research Councils (EMRC) Forward Look report ESF focuses on science driven collaboration between the best European researchers in all disciplines. We promote the identification and advancement of leading edge science in Europe in close co-operation with our Member Organisations. We bring together leading scientists, scholars and funding agencies to explore new directions in research and to plan and implement European level research collaboration in a global context. Our main instruments include conferences, scientific foresights, collaboration programmes and support to outstanding young researchers. ESF also manages COST, an intergovernmental framework for European co-operation in the field of Scientific and Technical Research. Integrative Biology is currently a hot topic in the Life Sciences. The potential applications of Integrative Biology will contribute significantly to maximizing the value of knowledge generated in the biomedical field and the outcome expected for the public health care system. In this context, the strategy developed by the European Medical Research Councils (EMRC), one of the five Standing Committees at ESF, aims to: • foster an interdisciplinary approach towards the Functional Genomics domain embracing all the –omics disci- plines (including the DNA, RNA, protein and other macromolecules world) and their integration into Systems Biology; • focus on biomedical applications emerging from these and related domains, such as Nanomedicine
    [Show full text]
  • UNMET NEEDS in 2020 Exploring What Innovation Means Today
    VOLUME 38 NUMBER 03 MARCH 2020 UNMET NEEDS IN 2020 Exploring What Innovation Means Today Underserved Areas: Looking Beyond Discussing The Past, Present And Focusing On Collaborative Cancer And Rare Diseases Future Of Cell And Gene Therapies Not ‘Innovative’ Ways To Pay PAGE LEFT BLANK INTENTIONALLY invivo.pharmaintelligence.informa.com STRATEGIC INSIGHTS FOR LIFE SCIENCES DECISION-MAKERS CONTENTS ❚ March 2020 UNMEET NEEDS IN 2020 Exploring What Innovation Means Today 10 14 18 Defining Go And No-Go Disease Discussing The Past, Present And Underserved Areas: Looking Areas As An R&D Business Future Of Cell And Gene Therapies Beyond Cancer And Rare Diseases ED SILVERMAN LUCIE ELLIS MELANIE SENIOR Some believe unmet need refers only to Founding CEO of the UK’s Cell and Gene Oncology and rare diseases dominate the rare diseases and tiny patient Therapy Catapult, Keith Thompson, will industry pipeline, fueled by science, populations. But it is more than this. In retire from the company this year. He regulatory tailwinds and high prices. But 2020, the term sits at the heart of looks back on the last eight years of as the world grapples with coronavirus, decision-making for drug makers – along progress for CGT Catapult and the and with heart disease still the top killer, with cost, access and value, of course. advanced therapies sector – and can our systems fund treatments for more provides words of wisdom for the prevalent conditions? challenges still to come. 24 28 34 UK, Sweden Test Differing Focusing On Collaborative Not EU Health Innovation Partner- Antibiotic Market Models ‘Innovative’ Ways To Pay ship Reflects Medtech’s Role In STEN STOVALL LEELA BARHAM Unmet Needs Sweden and the UK are conducting Innovation is defined by the Cambridge ASHLEY YEO differing “develop and test” programs to dictionary as “(the use of) a new idea or The EU Partnership on Health Innovation, assess so-called “pull” incentives in method.” The term is bandied about a a new public private health care research which an antibiotics innovator will be great deal in the life sciences industry.
    [Show full text]
  • Nanobiotix Announces Changes to Its Non Executive Board
    NANOBIOTIX ANNOUNCES CHANGES TO ITS NON EXECUTIVE BOARD Paris, April 4 th 2011 - NANOBIOTIX the leading nanomedecine firm focused on cancer therapy, announced today the following changes of its Supervisory Board : - Patrick Langlois has decided to resign from the Supervisory Board where he was Chairman since 2006. - Laurent Condomine has been elected Chairman of the Supervisory Board . He joined the Board of Nanobiotix in September 2010 to reinforce the company and to help in the translation of its breakt hrough technology and products, NanoXray, into value for patients, as well as for Nanobiotix shareholders and its employees . - Christophe Douat has been elected to the board . He was on the board of Nanobiotix from 2006 to 2009, when h e was instrumental in defining the company’s strategy. “Nanobiotix has a great potential and should become a leading company in the nanomedecine area wher e the team has shown a unique expertise, I wish Laurent Condomine all the success ; I am convinced he will contribute extensively to the future of Nanobiotix “ says Patrick Langlois . “The management wants to express its gratitude to Patrick Langlois who has efficiently guided Nanobiotix during several years . Thanks to Patrick and the support of our shareholders, Nanobiotix has managed to become a leading company in the nanomedicine field “ says Dr. Laurent Levy, CEO and co -founder of Nanobiotix. “Patrick can be pleased and proud of where Nanobiotix is today. During his tenure the company moved from one with a great scientific concept to one about to start clinical trials in man for its lead product. Nanobiotix has benefited from his experience, knowhow and commitment.
    [Show full text]
  • Nanobiotix Announces the Launch of Curadigm: a New
    NANOBIOTIX ANNOUNCES THE LAUNCH OF CURADIGM: A NEW NANOTECHNOLOGY PLATFORM FOR HEALTHCARE • Curadigm opens new growth pathways for Nanobiotix beyond oncology, built on the success and know-how established through the development of NBTXR3 • Curadigm will operate as a wholly-owned subsidiary of Nanobiotix and the platform will be further developed through multiple anticipated partnerships • Curadigm “Nanoprimer” technology aims to prime the body to receive various therapeutics and could reshape the balance between efficacy and toxicity for patients • In vivo proof of concept data were presented during AACR 2019 “After achieving the milestone of our first European market approval for Nanobiotix’s lead oncology product candidate, NBTXR3, our business continues to build momentum. We are thrilled to announce the launch of our subsidiary, Curadigm—another disruptive technology platform we have built as a result of pioneering nanomedicine for more than 15 years. While Nanobiotix remains focused on continued development of NBTXR3, we are pleased to open new growth pathways for our business and shareholders.” – Laurent Levy, CEO of Nanobiotix Paris, France and Cambridge, Massachusetts, USA, May 28, 2019 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the launch of new subsidiary Curadigm, dedicated to redefining the therapeutic balance between bioavailability, toxicity, and efficacy across the pharmaceutical industry. The company will be a wholly-owned subsidiary of Nanobiotix and operate in France and in the US with a dedicated team committed to growth and potential financing opportunities. For most therapeutics today, only a small portion of the medicine administered is effective and the rest is cleared from the body without effect or may even be toxic.
    [Show full text]
  • Nanobiotix Welcomes Laurent Condomine on Board
    PRESS RELEASE Nanobiotix welcomes Laurent Condomine on board Paris, September 7th 2010 - Nanobiotix, the leading nanomedecine firm, Paris based, announces today that Laurent Condomine joins its Non Executive Board to help its growth. “I am very pleased to join the Board of Nanobiotix. It is developing a portfolio of a new class of therapeutics that have the potential to transform cancer treatment. I am determined to help the company translate this breakthrough technology into value for patients, and for Nanobiotix Shareholders and its people ” says Laurent Condomine. “ I am impressed by the team and I look forward to working with its Management and with the Board, to release the impressive potential of its product portfolio. ” “We are proud to welcome Laurent Condomine, a passionate pharmaceutical executive who is going to play a key role in helping Nanobiotix growth. Laurent Condomine has all the qualities we were looking for to reinforce leading position in nanomedicine and make it fit into the pharma world. The focal point of his career has been pharma industry, and he has a clear understanding of small biotech companies requirements in terms of partnerships and development. He will collaborate side by side to our staff and board members “. Says Laurent Levy, CEO co-founder of Nanobiotix. Laurent Condomine, has been VP Business Development of AstraZeneca in its HQ, based in London. He was in charge of developing the Corporate Strategy of the Group, and of delivering its external growth component. He previously held a similar position with ICI when he was involved in the demerger of this company in 1993, then with Zeneca where he played a key role in its merger with Astra in 1998.
    [Show full text]
  • Metals As Radio-Enhancers in Oncology: the Industry Perspective
    Biochemical and Biophysical Research Communications xxx (2015) 1e5 Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: www.elsevier.com/locate/ybbrc Review Metals as radio-enhancers in oncology: The industry perspective * Agnes Pottier , Elsa Borghi, Laurent Levy Nanobiotix, 60 rue de Wattignies, 75012 Paris, France article info abstract Article history: Radio-enhancers, metal-based nanosized agents, could play a key role in oncology. They may unlock the Received 4 September 2015 potential of radiotherapy by enhancing the radiation dose deposit within tumors when the ionizing Accepted 5 September 2015 radiation source is ‘on’, while exhibiting chemically inert behavior in cellular and subcellular systems Available online xxx when the radiation beam is ‘off’. Important decision points support the development of these new type of therapeutic agents originated from nanotechnology. Here, we discuss from an industry perspective, Keywords: the interest of developing radio-enhancer agents to improve tumor control, the relevance of nano- Radio-enhancer technology to achieve adequate therapeutic attributes, and present some considerations for their Nanotechnology Cancer development in oncology. © Radiotherapy 2015 Published by Elsevier Inc. Contents 1. Introduction . ................................................. 00 2. Acting from within the cancer cells: radio-enhancers represent an attractive approach for successful tumor control . .......... 00 3. Metals as radio-enhancers: the values of nanotechnology . .. .................................... 00 3.1. Nanoparticles' size . ....................... 00 3.2. Nanoparticles' shape . ....................... 00 3.3. Nanoparticles'surface . ....................... 00 4. Metal-based nano-crystals as radio-enhancers: key requirements for development . ..................... 00 5. Considerations for development of metal-based nanoparticles as radio-enhancers in oncology . ..................... 00 5.1. A tool which may bring solution to unmet medical needs .
    [Show full text]