A By LeslieRidgeway earthquake victims team aidsNepal Medical response A are partofKeckMedicineUSC: for thethreeacutecarefacilitiesthat dren’s HospitalLosAngeles. served asSVPandCOOforChil- effective June15.Hannersformerly and USCNorrisCancerHospital, CEO ofKeckHospitalUSC officer ofKeckMedicineUSC. been appointedasthechiefoperating ence inhealthsystemsleadershiphas department physician, ananesthesiologist,a critical care/trauma surgeons, anemergency in Haiti.TheNepalgroupincludes two of asimilareffort in2010afteranearthquake Center providedmedicalsupplies. School ofMedicineandLAC +USCMedical surgical criticalcareteam. BoththeKeck with othermembersofthetraumaand Surgery, KeckSchoolofMedicine,along and surgical criticalcare, Departmentof Demetriades, MD,chief,divisionoftrauma A. Puliafito,MD,MBA,andDemetrios Keck SchoolofMedicineDeanCarmen catastrophic April25earthquakeinNepal. assist withcriticalcareofvictimsthe departed May4todeliversuppliesand Keck MedicineofUSC gets newCOO Hanners willoverseeoperations Rod Hannerswillalsoserveas All membersoftheNepalteam werepart The responsewasspearheadedby are notequally desirable Study findsallsugars W By LesDunseith two typesofsugar, glucose brain andbodyrespondto ers focusedonhowthe to eat.” because theyarepleasurable often seekoutsweetfoods them tastebetter, andwe foods anddrinkstomake said. “Sugarisaddedto loaded withsugar,” Page the motivationtoeat. brain rewardpathwaysand derstand howsugaraffects that soughttobetterun- details theresultsofastudy School ofMedicineUSC, of MedicineattheKeck MD, assistantprofessor Edition, KathleenPage, Academy ofSciences’Early the ProceedingsofNational cine ofUSC. researchers atKeckMedi- according toanewstudyby predisposed todoitagain, indulgence makesourbrains executive withsignificantexperi- Los Angeles-areahealthcare the KeckSchoolofMedicineUSC six-person medicalresponseteamfrom MAY 8•2015 In thisstudy, research- “The Americandietis In apaperpublishedin sweeteners, one hen itcomesto See NEPAL , page 3 Study participantswereStudy shownimages oftastyfoodssuchaspizza. tasty, foodswithlotsoffruc- salad dressings.Although soft drinks,honeyandmany of fructoseincludemost liver. Foodswithhighlevels mainly metabolizedinthe fruits andvegetablesthatis a simplesugarfoundin ing thebrain.Fructoseis in thehumanbody, includ- fruit, fuelsallofthecells foods, suchasbreadand carbohydrate-containing which isfoundinnearlyall and fructose.Glucose, PUBLISHED FORTHEUSCHEALTH SCIENCESCAMPUSCOMMUNITY of USC. president andCEO,KeckMedicine explains Tom Jackiewicz,seniorvice throughout SouthernCalifornia,” we continuetodevelopournetwork medical center, itisimperativethat coming theregion’s leadingacademic volume. system’s growthinmarketshareand Hills Hospital.Hannerswillleadthe Cancer HospitalandUSCVerdugo Keck HospitalofUSC,USCNorris In additiontohistenurewithKeck “In ordertoreachourgoalofbe- See SUGAR,page 3 Embrey, Edward Newton, Kenji ShihabSugeir. Inaba, From left: Lydia Paolim, Lam,Ramona Karen Kim Kathleen Page, MD allow ourphysicianstofocusonpro- leadership teamofthesamecaliberto Hanners wearebuildingastrong physicians. With theadditionofRod ern California. Kaiser PermanentefacilityinSouth- Medical Center(LAMC),thelargest Permanente Hospital’s LosAngeles as chiefoperatingofficerforKaiser Hanners’ experienceincludesserving Children’s HospitalLosAngeles, School ofMedicineUSC-affiliated “We haveafacultyofworld-class

Les Dunseith MD, assistantprofessorof by SophoclisAlexopoulos, operations wereperformed wife, Claudia. transplant intoHernandez’ in thelateafternoonfor and flowntoLAX,arriving Hopkins donorwasremoved morning, akidneyfromthe at JohnsHopkins.Thenext flown overnighttoapatient afternoon ofApril23and Raul Hernandezonthe was removedfromdonor recipient pair. kidney withanotherdonor/ recipient exchangesa patible withanintended kidney donorwhoisincom- a “kidneyswap,”living exchange, alsoknownas cal CenterofUSC. into apatientatKeckMedi- kins HospitalinBaltimore exchange withJohnsHop- kidney obtainedthroughan successfully transplantinga transplant onApril24, pleted itsfirstpairedkidney Centinela Valley areatend cates thatresidents inthe and Lawndale. Angeles, Watts, Compton of Hawthorne,Lennox,Los includes Inglewood,parts the CentinelaValley, which risk oflungcancerlivingin dose CTs forpeopleathigh finance twoyearsoflow- munity Foundationwill from theCaliforniaCom- Angeles County. poorest communitiesinLos residents ofsomethe via low-doseCTscansfor free lungcancerscreening million dollarstoprovide a grantofmorethanhalf Radiology hasbeenawarded T and LeslieRidgeway By LesDunseith paired kidney transplant USC completes itsfirst T By Douglas Morino County screenings inpartsofL.A. Radiology grant to fundlung cancer Both LosAngeles In thiscase,akidney In apairedkidney Recent research indi- The $503,560infunding See HANNERS,page 3 transplant teamcom- he USCabdominal USC Departmentof he KeckMedicineof Rod Hanners VOLUME 2•NUMBER9 Christopher Lee, MD ing participantsinthepaired and Raulwerelistedaswill- be incompatible. donor, buthewasfoundto unteered tobeherkidney year. Atthetime,Raulvol- Keck HospitalofUSCthat went transplantevaluationat dialysis in2011andunder in Georgia. Claudiastarted children andcurrentlylive Hernandez havethree his wifeClaudiaSanchez- year fromherdaughter, Ana. transplant inMarchofthis a successfullivedonorliver Petra Hernandez,received nandez family. Raul’s cousin, transplant involvingtheHer first successfullivedonor coordinator, thiswasnotthe Yamasaki, transplant of USC. program atKeckMedicine kidney-pancreas transplant MD, medicaldirectorofthe was overseenbyYasir Qazi, paired kidneyexchange process ofarrangingforthe Keck MedicalCenter. The of kidneytransplantationat clinical surgery anddirectory access,” saidChristopher lot ofbarriersto healthcare happens tobefacedwitha high-risk populationthat communities. in otherSouthernCalifornia cancer athigherratesthan to smokeanddeveloplung Yamasaki saidthatClaudia Raul Hernandezand According toNoriko “We aretargeting avery See KIDNEY,page 2 See GRANT,page 2 - - Natalie Cisneros Walter Urie MAY 8 • 2015 GRANT: Funds for lung cancer screening Continued from page 1 two years. To facilitate the series of detailed cross- Lee, MD, associate professor screening process, trans- sectional X-ray images of of clinical radiology at the portation to and from Keck the lungs. A low-dose CT Keck School of Medicine Medical Center of USC will does not require intravenous of USC. “Lung cancer is be provided. contrast, takes less than five the leading cause of cancer Residents will also have minutes to perform and is death for both men and access to local smoking performed with about one- John R. Hubanks Milan J. Demeter George B. Stoneman women in this country, but cessation resources. If an fifth of the radiation dose of it particularly afflicts those abnormality is detected on a conventional CT scan. Demeter Otolaryngology Practice living within underserved the low-dose CT, patients The grant will allow the communities. This is a great will be linked to appropri- FDA-approved technology joins with Keck Medicine of USC opportunity to be able to ate follow-up and treatment to be accessible to a large By Meg Aldrich is becom- reach out to this population resources. underserved population, ing the eck Medicine of USC is and educate them on the “Our goal is to eliminate said Zul Surani, executive practice of importance of early detec- joining with the barriers as much as possible, director for community part- K choice for tion of lung cancer, as well Demeter, Hubanks and especially financial barri- nerships for USC’s Health physicians as smoking cessation for the Stoneman Otolaryngology ers,” Lee said. “It’s really Sciences Campus. in Southern prevention of lung cancer. Practice to form USC Oto- important to reach out to “How do you take California Hopefully, we can save some this population because they technology that’s proven laryngology Associates in the who want lives in the process.” are the population at highest effective and underutilized communities of La Cañada Karla O’Dell to align The Department of risk for developing lung to people who need it the Flintridge and Glendale. their practices with the re- Radiology has partnered cancer.” most? To me, that’s a matter As part of the USC De- search and clinical expertise with USC’s Health Sci- One of the largest random- of justice,” Surani said. partment of Otolaryngology- that a leading university- ences Campus Community ized controlled clinical trials “People who are uninsured Head & Neck Surgery, the based medical center of- Partnerships Office and the in National Cancer Institute and underserved are in practice becomes part of a fers,” says Amar A. Desai, USC Norris Comprehensive history showed that low- need of this new screening world-class team that offers MD, MPH and CEO of Cancer Center, as well as the dose CT screening could modality, yet they don’t medical and surgical care USC Care and Ambulatory Watts Health Foundation, reduce lung cancer mortality have access to it. How do we to patients with disorders Services, part of Keck Medi- to enroll residents for lung rates by at least 20 percent, a bridge that gap? This grant of the ear, nose, throat and cine of USC. “We partner cancer screening. significant improvement for will help us do exactly that.” related structures of the with working physicians who As a part of the grant, a cancer that currently has a The California Commu- head and neck. starting in June, the Depart- five-year overall survival rate nity Foundation is a public The Glendale practice are already well-established ment of Radiology plans to of only 17 percent. charity focused on philan- was founded by John R. in their communities and screen about 400 Centinela A CT scan is an imaging thropy and civic engagement Hubanks, MD, in 1971. work collaboratively with Valley residents over the procedure that creates a across L.A. County. Milan J. Demeter, MD, these excellent physician joined in 1979 and currently practices to make advanced serves as chief physician. care more accessible within George B. Stoneman, MD, their communities.” joined in 2010. Now, all In 2014, the Department three esteemed physicians of Otolaryngology – Head & will be part of Keck Medi- Neck Surgery at the Keck cine of USC’s medical group, School of Medicine of USC allowing the local practice was No. 10 in funding from to expand services at its the National Institutes of existing locations in both Health, surpassing the likes communities. of Harvard University and One of the Keck Medi- New York University. cine of USC physicians and “My colleagues and I are audiologists who will help thrilled to join forces with deliver patient care is Karla USC because it means our O’Dell, MD, a laryngologist patients have access to the specializing in voice, airway most advanced care and COMMUNITY ENGAGEMENT: Longtime community outreach services providers and stakeholders and swallowing disorders. cutting-edge procedures,” have been convened by HSC Community Partnerships in Civic Engagement at HSC to meet regularly She will perform office- Demeter said. “Everything and exchange ideas, discuss best practices and form collaborations. Represented are the USC School based laryngeal procedures we do is about enhancing of Pharmacy, Keck Medicine of USC, USC Norris Comprehensive Cancer Center, USC Civic Engagement such as vocal cord injections, the care we’re able to give and the Division of Biokinesiology and Physical Therapy. From left are Kukla Vera, Cheryl Resnick, Isabel Botox injections and laser our patients, and this part- Duenas, Executive Director Zul Surani, Melisa Acoba, Elena Nieves and Lourdes Ortega. procedures at both locations. nership is a big advantage “Keck Medicine of USC for those we serve.”

KIDNEY: Paired Calendar of Events surgery success Saturday, May 9 “Research Seminar: HIV and the Human Tri-institutional Stem Cell Retreat,” The Fess Microbiome,” Jeffrey M. Bender, MD, USC. Parker: A Doubletree Hilton Resort, Santa Continued from page 1 8 a.m. – 4 p.m. The Office of CME & the De- kidney donation database in Auditorium, Saban Building. Info: Harleen Barbara, CA. Info: Francesca Mariani, (323) partment of Medicine: Division of Endocrinol- July 2014. ogy, Neurology & Neurosurgery Continuing Gill, (323) 361-8626, [email protected], http:// 442-7855, [email protected], http://stem- “It’s great that Raul was Medical Education. “Annual Southern Califor- CHLA.org/TECPAD cell.usc.edu/tri-retreat nia Pituitary Symposium,” Course Directors: able to help someone else, Noon. Zilkha Neurogenetic Institute Seminar. John David Carmichael, MD, and Gabriel who in turn could help his “Synapses, Brain Disorders and Muscular Monday, May 18 Zada, MD, Aresty Auditorium. Info: Teresa wife to receive a kidney,” Dystrophy,” Lin Mei, PhD, Georgia Regents 10 a.m. – 8 p.m. USC Verdugo Hills Hospi- Ball, (323) 244-2555, [email protected] she said. “That’s what is so University. Herklotz Seminar Room, ZNI 112. tal Foundation and Keck Medical Center of wonderful about this paired Info: Julie Carl, (323) 442-3219, [email protected] USC. “Golf Classic 2015 – 24th Annual Golf kidney exchange program, Monday, May 11 Tournament,” Oakmont Country Club. Info and Keck Medicine of USC 10:30 a.m. Zilkha Neurogenetic Institute and RSVP: Deb Jordan, (818) 952-3553, deb. is proud to be a part of it.” Seminar. “Subdiffusive Encounter of Mem- Thursday, May 14 [email protected], http://www.uscvhh.org/ 1:30 p.m. Keck Medicine of USC Stroke Sup- The paired kidney brane Receptors: A Functional Role for Golf-Classic-2015 Plasma Membrane Hetereogeneity,” Edward port Group Meeting. “Recognizing Stroke exchange is becoming Lyman, PhD, University of Delaware. Eli Risk Factors,” Nerses Sanossian, MD, USC. Noon. KSOM Research Seminar Series increasingly common when a and Edythe Broad CIRM Center Auditorium. Keck Hospital, 3 North, Day Room (3261A). Seminar. “Hepatitis C Virus and Host Cell donor’s kidney is incompat- Info: Julie Carl, (323) 442-3219, [email protected] Info: Ozzy Obiwuru, (323) 442-0049, Interactions,” J-H James Ou, PhD, USC. Ar- ible with a relative or friend [email protected] esty Auditorium. Info: Mary Jane Chua, (323) who needs one. Instead 442-7732 [email protected] Tuesday, May 12 6 p.m. Orthopaedic Surgery Grand Rounds. of waiting for a stranger to 5:30 p.m. Ophthalmology Continuing Medi- “Amputation Surgery: Operative Principles donate or doctors to recover cal Education. Grace Shih, MD, USC. HC4, and Future Directions.” Benjamin Kyle Potter, Tuesday, May, 19 a kidney from a deceased Conference Room, 3rd Floor. Info: MD, Walter Reed National Military Medical Noon. Diabetes and Obesity Research Insti- body, recipients and donors Tyaisha Christopher, (323) 409-5233, Center. Aresty Auditorium. Info: RSVP: Sylvia tute Seminar. “Special Trainee Presentations,” in the database that seeks to [email protected] Suarez (323) 226-7204 [email protected] Travis Eurick, Eldin Dzubur, Bharti Bisht & pair them with people in the Timothy Moore, USC. Harkness Auditorium. same situation who appear to Wednesday, May 13 Sunday, May 17 Info: Christina Ayala, (323) 442-2500, Insti- match based on blood type Noon. The Saban Research Institute Seminar. 8 a.m. USC Stem Cell. “USC UCSF UCLA [email protected], http://dori.usc.edu. and genetic characteristics. More than 80,000 people are on the kidney transplant Notice: Calendar items are due at least 10 days before publication date. Timely submission does not guarantee publication in print. See more calendar entries at hscnews.usc.edu/calendar-of-events. Submit items at tinyurl.com/calendar-hsc. Include day, date, time, title of talk, first and last name of speaker, affiliation of waiting list. Each year, about speaker, location and a phone number/email address. 4,500 people die waiting for a kidney. Stem cell expert finds atypical partners for ALS research By Cristy Lytal SC Stem Cell researcher Justin UIchida, PhD, is forming partner- ships between academia, industry and government to accelerate the develop- ment of new treatments for patients with ALS, or Lou Gehrig’s disease. Steve Cohn Steve Ichida’s work will marshal the expertise of pharmaceutical company Medical School Sanofi and a startup company, DRVision Technologies, along with $1.5 million commencements in federal funding, in his effort to find Wednesday, May 13 new drugs to fight amyotrophic lateral MS, PhD & MPH — Medicine sclerosis (ALS). 4 p.m. at the Harry and Celeste The source of the three-year grant is unusual — the U.S. Department of Pappas Quad, Health Sciences Defense. Because military veterans are Campus. Approximately one more likely than civilians to suffer from hour. A reception will im- this fatal disease for reasons that are not mediately follow at the same yet understood, the Defense Depart- location. Tickets are required. ment funds two ALS Therapeutic Info: (323) 442-1607. Cristy Lytal Development Awards each year. Researcher Justin Ichida is seeking to identify a new drug target to benefit ALS patients. Speaker: Keith R. Yamamoto, “The awards are intended to either PhD, vice chancellor for identify a new drug target or candidate degeneration. He then puts these repro- Technologies, is designing software to research and executive vice for ALS, or to take an existing one grammed motor neurons into a robotic analyze the resulting microscopic images dean of the School of Medicine further into the clinic,” said Ichida, an screening machine, which exposes them for signs of improved motor neuron sur- of UC San Francisco. assistant professor in the Department to drug-like compounds and captures vival. If the funded study reveals viable of Stem Cell Biology and Regenerative microscopic movies of the results. In his hits, chemists at Sanofi may develop Friday, May 15 Medicine and the director of the Choi pilot screening of 800 compounds, he these compounds into safe, effective Occupational Science and Oc- Family Therapeutic Screening Facility found four that kept these motor neu- drugs to test in a human clinical trial. cupational Therapy at the Keck School of Medicine of USC. rons alive in Petri dishes — and eventu- Sanofi officials were introduced to 11 a.m. at Leavey Library, west Ichida has pioneered a way to ally might do the same in patients. Ichida’s research by USC Stem Cell lawn, University Park Campus. prescreen drug-like compounds in the With the new grant, Ichida will scale Program Director Qing Liu, PhD, who Tickets not required. Info: (323) laboratory on cells from patients with up efforts starting in September 2015, is managing the project. Ichida said the 442-2811. the most common form of ALS. To ac- screening 2,000 FDA-approved drugs partnership is one of the first examples Speaker: Wenchun Qu, MD, complish this, Ichida directly reprograms in his laboratory. Sanofi will screen an of taking a patient-specific disease PhD, assistant professor patients’ skin cells into motor neurons, additional 40,000 drug-like compounds. model from stem cells and using it to of physical medicine and which exhibit the disease’s signature The other industry partner, DRVision discover drugs at a pharmaceutical scale. rehabilitation at Mayo College of Medicine. Physician Assistant Program HANNERS: New COO starts June 15 10:45 a.m. at Allan Hancock Continued from page 1 operations and support Foundation Building, southwest viding the absolute best care services across the LAMC lawn, University Park Campus. to our patients,” Jackiewicz campus and medical office A reception will follow at the said. “Rod has an impressive buildings. same location. Tickets not background in improving Hanners will work to es- required. Info: (626) 457-4263. quality, managing costs, and tablish strong and effective leveraging resources in a working relationships with Biokinesiology and complex health care environ- key constituents across the Physical Therapy ment.” USC enterprise, including 11 a.m. at Bovard Auditorium, Jackiewicz, to whom department chairs, faculty University Park Campus. Tickets Hanners will report, con- and medical staff members, not required. tinued: “Having worked at as well as leadership at the Info: (323) 442-1193. Researchers found more activity in areas of the brain associated with two of the largest medical hospital and system level. Speaker: Anthony Carbajal, rewards from fructose, right, than from glucose, left. centers in California, he He will also engage stake- unofficial advocate for ALS understands the unique holders in the communities research.. challenges we face in the served by Keck Medicine of SUGAR: Fructose prompts strong Dentistry rapidly changing health care USC. 11 a.m. at McAlister Field, landscape and has demon- Preceding his health care hunger response, research shows University Park Campus. Tickets strated the ability to develop career, Hanners served in not required. Continued from page 1 breakfast. On one occasion, successful strategies and the United States Navy as a Info: (213) 740-2841. tose are often unhealthy. they consumed a drink processes for optimal growth nuclear engineer and subma- “Fructose fails to stimu- sweetened with fructose; on and stability.” rine training instructor. He Speaker: Michael Meru, DDS, late hormones, like insulin, another day, they consumed At CHLA, Hanners is the holds a bachelor’s degree in MS, orthodonist. that are important in helping a drink sweetened with glu- senior administrative officer electrical engineering from Health Promotion and us feel full,” Page noted. cose. Researchers sampled in charge of 10 departments, California State University, Global Health Programs When study participants blood for hormones that help including radiology, patient Long Beach and a master’s- 11 a.m. at Town and Gown, consumed fructose com- control appetite and per- care services, information equivalent in nuclear University Park Campus. A re- pared to glucose, it led to formed brain scans while the services and human re- engineering from the Naval greater activity in brain re- volunteers looked at pictures ception will follow at the same sources. At Kaiser, Hanners Nuclear Power School in location. Tickets are required. ward areas, greater ratings of of tasty foods (like pizza) was responsible for hospital Orlando, FL. hunger and more desire for or objects (like a lamp) and Info: (213) 821-1601. food. This tendency played rated their hunger and desire Speaker: Paul Gregerson, MD, out the same even when for food. “This allowed us to MBA, chief medical officer at participants were offered a see how consuming fruc- NEPAL: Medical JWHC Institute. monetary incentive not to tose compared to glucose response team School of Pharmacy indulge their sweet tooth. affected brain, hormone and joins quake effort 3 p.m. at the Harry and Celeste “We gave the volunteers hunger responses,” Page Pappas Quad, Health Sciences choices between being explained. Continued from page 1 Campus. A reception will follow served tasty food imme- The results suggest that nurse anesthetist and a reg- at 5 p.m. Tickets required. Info: diately after the study or consuming fructose relative istered nurse. The team will (323) 442-1383. having money sent to them to glucose activates brain be in Nepal for nine days. one month later,” Page reward regions and may Speaker: Sean Astin, actor and Members of the medical explained. “When the study promote feeding behavior. mental health advocate. response team are Lydia Les Dunseith participants consumed So, what should people do Lam, MD, trauma surgeon Shihab Sugeir, MD, of the USC Saturday, May 16 fructose, they had a greater first if they want to reduce team makes a final check willingness to give up the their fructose intake as part and assistant professor, MD/PhD, MD — Medicine Department of Surgery; of bags filled with medical 3 p.m. at the Galen Center, money to obtain immediate of controlling their diet and supplies headed to Nepal. high-calorie foods, compared living a healthier life? Ramona Paolim, registered University Park Campus. Doors to when they consumed “The best way to reduce nurse, LAC+USC Medical Medicine; team leader Kenji open at 2 p.m. A reception will glucose.” fructose intake is to decrease Center; Karen Kim Embrey, Inaba, MD, trauma surgeon follow at 5 p.m. on the Mc- The research is based on the consumption of added CRNA, assistant professor, and associate professor, Carthy Quad at the University 24 healthy young men and sugar sweeteners, which are Department of Anesthesiol- Department of Surgery; and Park Campus. Tickets are not women who came in for the main source of fructose ogy; Edward Newton, MD, Shihab Sugeir, M.D., assis- required. Info: (323) 442-2420. brain scans in the mid- in the American diet,” Page interim chief and professor, tant professor, Department Speaker: Charles Gibson, morning before they ate said. Department of Emergency of Anesthesiology. broadcast journalist HSC Newsmakers academic journalsandmentionsinthenews media: may include philanthropic donations,research grants, publicationin A roundup ofnews items related to Keck MedicineofUSC, which abuse, environmentalhealth,childhoodobesityandmore. mestic violence,gunmentalhealthandsubstance Topics includedimmigration,reproductivehealthanddo- students presentedaseriesofshorttalksoncurrentissues. F look into ophthalmology career Dean’s Scholargets afirst-hand Master ofPublic Health symposium County supervisorspeaks at A leaders inhospitalmedicine New fellowship program to train in thefieldofhospitalmedicine.” that otherswillfollowinordertopreparethefutureleaders resource management.Thiswilllikelybecomeamodel health care,includingquality, safety, cost-effectiveness and our fellows to learn key concepts regarding the delivery of outstanding institution, but it is crafted in a way that allows “This fellowshipnotonlyallowsformedicaltrainingatan and generalinternalmedicine at KeckMedicineofUSC. Karp, MD,theinterimchiefofgeriatrics,hospital,palliative terested inthefutureofhospitalmedicine,”saidMichael department. “This isauniqueopportunityforanyonein- for patientsadmittedthroughaclinicortheemergency in ahospitalsetting.Hospitalistsareresponsibleprimarily cine graduateswithexperienceinallaspectsofmedicine gram atApolloMedisdesignedtoprovideinternalmedi- program. TheUSCHospitalistLeadershipFellowshipPro- an intensiveone-yearhospitaliststrainingandeducational gram attheKeckSchoolofMedicineUSCwilllaunch care company, andtheInternalMedicineResidencyPro- patients.” — medicine in which you build long-term relationships with of all,Ichoseophthalmology becauseitisafieldof essential part of their quality of life,” hesaid.“But, most its abilitytooffer patientsremarkableimprovements toan long, and rangedfrom its mix of medicine andsurgery to “The listofthingsthatattracted metoophthalmologywas sees ophthalmologyasthebestfitforhispassionandskills. Los AngelesCounty+USCMedicalCenter. Matsunaga of itsexceptionalclinicalopportunities,includingworkat disease at UC Berkeley. He chose the Keck School because molecular andcellbiologywithafocusoninfectious attended SantaMonicaHighSchool.Matsunagastudied Born inLongBeach,MatsunagagrewupWest LAand as theacademicsideofdevelopingmedicaltechnology.” clinical applicationsofretinalimagingtechnology, aswell grateful fortheopportunitytobeimmersedinboth been arareandrewardingprivilege,”saidMatsunaga.“I’m of the founders ofopticalcoherence tomography —has vasculature. Working onOCTA withDeanPuliafito—one that enablesphysicianstonon-invasivelyobserveretinal angiography (OCTA), a cutting-edge imaging technique clinical applicationofopticalcoherencetomography MD, PhD,attheUSCEyeInstitute.Heisstudying Carmen A.Puliafito,MD,MBA,andAmirH.Kashani, Scholars Program.MatsunagaisworkinginthelabofDean dreams ofscientificdiscoveryintheDean’s Research Matsunaga have a wholeyearor more to pursue their Keck SchoolofMedicineUSC,studentslikeDoug go byinabluroflectures,labsandclinicalcare.Butat Medical studentDougMatsunaga works at theUSC Eye Institute. Ridley Thomas or pollo MAY 8•2015

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Robert Lurye gery attheKeckSchoolof laryngology andneurosur MD, PhD.professorofoto- otologist RickA.Friedman, reducing therisk,”said is animportantfactorin due toloudnoiseexposure susceptibility tohearingloss logical processesthataffect study authorssay. hazardous noiseexposure, protect theirhearingpriorto precautionary measuresto decide totakeadditional risk forhearinglossmay sation. receiving disabilitycompen- disabilities amongveterans as oneofthemostcommon Affairs reportedhearingloss Department ofVeterans Armed Forces.In2013,the high riskaretroopsinthe and Health.Atespecially for OccupationalSafety ing totheNationalInstitute in theUnitedStates,accord- mon work-relatedillnesses loss isoneofthemostcom- loss thanothers. to noise-inducedhearing more geneticallysusceptible that somepeoplemaybe entists hasfoundevidence Medicine ofUSCneurosci- national teamledbyKeck A By JohnHobbs One step closer to natural tooth restorations I By AlisonTrinidad loss hearing Genetic linkfoundinnoise-induced their dentalepithelial stem due tothediffering fatesof differ in tissue homeostasis developmental processes but and molarsstartwithsimilar per focusedonhowincisors formation. stop developingaftercrown molars, which,asinhumans, with thosethatbecome that becomemouseincisors ogy —comparedthecells Craniofacial MolecularBiol- director oftheCenterfor of DentistryUSCand Herman OstrowSchool Molecular Biologyatthe Boone ChairinCraniofacial the George andMaryLou dean ofresearch,holder Chai, DDS,PhD,associate research team—ledbyYang incisor. Inthestudy, the continuously growingrodent mechanisms underlyingthe ers studiedthebiological opment Cell,USCresearch- the May2015issueofDevel- the dentaloffice. “fillings” —arehandledin tions —crowns,bridgesand the waydentalrestora- teeth, whichcouldchange how toregeneratehuman ers powerfulinsightinto tal anatomygivesresearch- might sound,arodent’s den- that theanimalmightstarve. checked, couldgrowsolong incisors, which,ifleftun- down thoseever-growing anything. Theyneedtowear through, well,justabout bars, andratswillchew mindlessly onmetalcage cupboards, hamsterschomp that micegnawthrough “Understanding thebio- Those athighergenetic Noise-induced hearing “The majorideaofthepa- In anarticlepublishedin As unappealingasitall It’s oneofthereasons association study, aninter n anewgenome-wide stop growing. rodent’s incisorsnever - - Web: hscnews.usc.edu |kecknet.usc.edu Email: [email protected] 442-2832 Fax: (323) 442-2830 Phone: (323) Shahinian, SherriSnellingandAlison Trinidad Matthieu, Douglas Morino, Sara Reeve, LeslieRidgeway, Talar Contributors: Sharon Brock, Tania CristyLytal, Chatila, Carol Director, Internal Communications:Virginia Baca Editor: LesDunseith may bereproduced withoutthecreator’s consent. reprint articles isavailable uponrequest. Noartwork Public Relations andMarketing staff. Permission to community. isproduced It by Sciences theHealth of Southern California’s Campus Sciences Health students, volunteers andvisitors intheUniversity HSC News ispublishedforthefaculty, staff, HSC News Los Angeles, CA90032 2011 NSoto Street -SST-2830 Public Relations andMarketing USC Health Sciences are associatedwithatrait. see ifanyofthosevariants common geneticvariantsto the entiregenomefor studies, orGWAS, search Genome-wide association their resultsunreplicated. past, allwereverysmalland have beenconductedinthe duced hearinglossinpeople sociation studiesonnoise-in- tion ofPLOSGenetics. appears intheApril16edi- noise-induced hearingloss,” gene forsusceptibilityto identifies Nox3asacritical wide associationstudy loss inthefirstplace.” have andpreventinghearing protecting thehearingyou nothing cancompareto in hearingrestoration,but have madegreatadvances author ofthestudy. “We Medicine ofUSCandsenior tion ofmolarsliesdormant, while thestem-cellpopula- growing throughoutlife stem cellstokeepthem epithelial andmesenchymal with abustlingpopulationof cell fatesthatleaveincisors Anh Ho. other studentwasHoang involved inthestudy. The one oftwodentalstudents cells,” saidWeston Grimes, Friedman Rick A. Although somegeneas- The study, “Genome- It’s thesedifferent stem

Don Milici soal deNívelSuperior. de AperfeiçoamentoPes- Medicine andCoordenação Institute forRegenerative tutes ofHealth,California part bytheNationalInsti- The studywassupportedin Maya Monges-Hernadez. Salehide, AnthonMyintand Qingzhong Li,Pehzman A. Aaron,MariaK.Ho, Crow, JuemeiWang, Ksenia Joel Lavinsky, AmandaL. cine ofUSCauthorsinclude Other KeckSchoolofMedi- Grande doSulandUCLA. Federal UniversityofRio in collaborationwithBrazil’s in mice. noise-induced hearingloss first publishedGWAS for investigation, leadingtothe the statisticalpowerofits team wasabletoincrease Mouse DiversityPanel,the of miceintheHybrid Using 64ofthe100strains noise-induced hearingloss. gene forsusceptibilityto in theinnerear, asakey almost exclusivelyexpressed the Nox3gene,whichis Friedman’s teamidentified Neurogenetic Institute, conducted attheZilkha relevance topeople. traits thathaveimmediate genes involvedincomplex the discoveryofhundreds Mouse GWAS haveledto Chai explained. of amalgamorporcelain, place abrokentoothinstead regenerated inalabtore- day reachforalivingtooth in time,adentistmightone root,” Chaisaid. could regrowpartofthe those stemcells,thenwe this knowledgetoreactivate the articleexplained. The studywasconducted In theUSCstudy, The discoverymeansthat, “If wecansomedayuse May 22 Next Issue: Non-Profit Organization U.S. POSTAGE PAID Permit 4029 Industry CA Industry