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Cognitive Dysfunction in Bipolar Disorder

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Cognitive Dysfunction in Bipolar Disorder Cognitive Dysfunction in Bipolar Disorder A Guide for Clinicians Edited by Joseph F. Goldberg, M.D. Katherine E. Burdick, Ph.D. Washington, DC London, England Note: The authors have worked to ensure that all information in this book is ac- curate at the time of publication and consistent with general psychiatric and med- ical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S. Food and Drug Administration and the general medical community. As medical research and practice continue to advance, however, ther- apeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because hu- man and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family. Books published by American Psychiatric Publishing, Inc., represent the views and opinions of the individual authors and do not necessarily represent the policies and opinions of APPI or the American Psychiatric Association. If you would like to buy between 25 and 99 copies of this or any other APPI title, you are eligible for a 20% discount; please contact APPI Customer Service at [email protected] or 800-368-5777. If you wish to buy 100 or more copies of the same title, please e-mail us at [email protected] for a price quote. Copyright © 2008 American Psychiatric Publishing, Inc. ALL RIGHTS RESERVED Manufactured in the United States of America on acid-free paper 12 11 10 09 08 5 4 3 2 1 First Edition Typeset in Adobe Galliard and Optima American Psychiatric Publishing, Inc. 1000 Wilson Boulevard Arlington, VA 22209-3901 www.appi.org Library of Congress Cataloging-in-Publication Data Cognitive dysfunction in bipolar disorder : a guide for clinicians / edited by Joseph F. Goldberg, Katherine E. Burdick.—1st ed. p. ; cm. Includes bibliographical references and index. ISBN 978-1-58562-258-0 (alk. paper) 1. Manic-depressive illness. 2. Cognition disorders. I. Goldberg, Joseph F., 1963– II. Burdick, Katherine E., 1972– [DNLM: 1. Bipolar Disorder—complications. 2. Bipolar Disorder—physiopa- thology. 3. Cognition—physiology. 4. Cognition Disorders—etiology. WM 207 C6756 2008] RC516.C62 2008 616.89’5—dc22 2008014109 British Library Cataloguing in Publication Data A CIP record is available from the British Library. Contents Contributors . ix Foreword . xv Frederick K. Goodwin, M.D. Preface. xix Joseph F. Goldberg, M.D., and Katherine E. Burdick, Ph.D. 1 Overview and Introduction: Dimensions of Cognition and Measures of Cognitive Function . 1 Katherine E. Burdick, Ph.D., and Terry E. Goldberg, Ph.D. 2 Attentional and Executive Functioning in Bipolar Disorder . 23 Luke Clark, D.Phil., and Guy Goodwin, M.D. 3 Memory Deficits Associated With Bipolar Disorder . 49 Safa Elgamal, M.D., M.Sc., Ph.D., Marta Sokolowska, Ph.D., and Glenda MacQueen, M.D., Ph.D. 4 The Endophenotype Concept: Examples From Neuropsychological and Neuroimaging Studies of Bipolar Disorder . 69 David C. Glahn, Ph.D., Katherine E. Burdick, Ph.D., and Carrie E. Bearden, Ph.D. 5 Impact of Mood, Anxiety, and Psychotic Symptoms on Cognition in Patients With Bipolar Disorder. 89 Gin S. Malhi, M.B.Ch.B., B.Sc. (Hons), F.R.C.Psych., F.R.A.N.Z.C.P., M.D., Catherine M. Cahill, M.Sc., M.Psychol., and Philip Mitchell, M.B., B.S., M.D., F.R.A.N.Z.C.P., F.R.C.Psych. 6 Improving Psychotherapy Practice and Technique for Bipolar Disorder: Lessons From Cognitive Neuroscience . 113 Joseph F. Goldberg, M.D., Cory F. Newman, Ph.D., Gin S. Malhi, M.B.Ch.B., B.Sc. (Hons), F.R.C.Psych., F.R.A.N.Z.C.P., M.D., and David J. Miklowitz, Ph.D. 7 Adverse Cognitive Effects of Psychotropic Medications . 137 Joseph F. Goldberg, M.D. 8 Pharmacologic Strategies to Enhance Neurocognitive Function . 159 Joseph F. Goldberg, M.D., and L. Trevor Young, M.D., Ph.D. 9 Cognitive Dysfunction in Children and Adolescents With Bipolar Disorder: Relative Contributions of Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder. 195 Paula K. Shear, Ph.D., and Melissa P. DelBello, M.D. 10 Cognition and Functional Outcome in Bipolar Disorder. 217 Ivan J. Torres, PhD., Colin M. DeFreitas, M.A., and Lakshmi N. Yatham, M.B.B.S., F.R.C.P.C., M.R.C.Psych. 11 Cognition Across the Life Span: Clinical Implications for Older Adults With Bipolar Disorder . 235 Eduard Vieta, M.D., Ph.D., Anabel Martinez-Aran, Ph.D., and Joseph F. Goldberg, M.D. 12 Summary and Assessment Recommendations for Practitioners. 257 Joseph F. Goldberg, M.D., and Katherine E. Burdick, Ph.D. Index . 273 Contributors Carrie E. Bearden, Ph.D. Assistant Professor in Residence, Jane & Terry Semel Institute for Neuro- science and Human Behavior, Department of Psychiatry and Biobehav- ioral Sciences and Department of Psychology, University of California, Los Angeles, California Katherine E. Burdick, Ph.D. Assistant Professor of Psychiatry, Albert Einstein College of Medicine, the Bronx, New York; Director, Neurocognitive Assessment Unit, Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Is- land Jewish Health System, Glen Oaks, New York Catherine M. Cahill, M.Sc., M.Psychol. Clinical Psychologist, University of Sydney, Northern Clinical School, Royal North Shore Hospital; Clinical Psychologist, Traumatic Stress Clinic, Westmead Hospital, Sydney, Australia Luke Clark, D.Phil. University Lecturer, Department of Experimental Psychology, University of Cambridge, Cambridge, England Colin M. DeFreitas, M.A. Graduate Student, Department of Psychology, Simon Fraser University, Burnaby, British Columbia Melissa P. DelBello, M.D. Vice-Chair for Clinical Research and Associate Professor of Psychiatry and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Safa Elgamal, M.D., M.Sc., Ph.D. Schlegel Research Chair in Aging and Assistant Professor of Cognitive Neuroscience, University of Waterloo, Waterloo, Ontario, Canada ix x Cognitive Dysfunction in Bipolar Disorder David C. Glahn, Ph.D. Director of Neuroimaging Core in Psychiatry and Associate Professor, De- partment of Psychiatry and Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas Joseph F. Goldberg, M.D. Associate Clinical Professor of Psychiatry, Mount Sinai School of Medi- cine, New York, New York; Director, Affective Disorders Research Pro- gram, Silver Hill Hospital, New Canaan, Connecticut Terry E. Goldberg, Ph.D. Professor of Psychiatry, Albert Einstein College of Medicine, Bronx, New York; Director of Research in Neurocognition, Division of Psychiatry Re- search, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York Guy Goodwin, M.D. W.A. Handley Professor of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England Glenda MacQueen, M.D., Ph.D. Head, Mood Disorders Program; Associate Professor, Department of Psy- chiatry and Behavioral Neurosciences; Adjunct Member, Intestinal Dis- eases Research Program, McMaster University, Toronto, Ontario, Canada. Gin S. Malhi, M.B.Ch.B., B.Sc. (Hons), M.R.C.Psych., F.R.A.N.Z.C.P., M.D. Professor and Head, Discipline of Psychological Medicine, University of Sydney, Sydney, Australia Anabel Martinez-Aran, Ph.D. Head of the Neuropsychology Bipolar Disorders Program, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, University of Barce- lona, Barcelona, Spain David J. Miklowitz, Ph.D. Professor of Psychology and Psychiatry, Department of Psychology, Uni- versity of Colorado, Boulder, Colorado Contributors xi Philip Mitchell, M.B., B.S., M.D., F.R.A.N.Z.C.P., F.R.C.Psych. Professor and Head, School of Psychiatry, University of New South Wales, New South Wales, New Zealand Cory F. Newman, Ph.D. Director, Center for Cognitive Therapy, Associate Professor of Psychol- ogy, Department of Psychiatry, University of Pennsylvania School of Med- icine, Philadelphia, Pennsylvania Paula K. Shear, Ph.D. Professor of Psychology and Psychiatry, Director of Clinical Training, and Codirector of Graduate Studies, Department of Psychology, University of Cincinnati, Cincinnati, Ohio Marta Sokolowska, Ph.D. Research Scientist, Department of Clinical Pharmacology, DecisionLine Clinical Research Corporation, Toronto, Ontario, Canada Ivan J. Torres, Ph.D. Associate Professor L.T., Department of Psychology, Simon Fraser Uni- versity, Burnaby, British Columbia; Clinical Neuropsychologist, Riverview Hospital, Coquitlam, British Columbia; Research Scientist, BC Mental Health and Addiction Services; Research Consultant, Mood Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada Eduard Vieta, M.D., Ph.D. Professor of Psychiatry, University of Barcelona; Director of the Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de In- vestigación Biomédica en Red de Salud Mental, University of Barcelona, Barcelona, Spain Lakshmi N. Yatham, M.B.B.S., F.R.C.P.C., M.R.C.Psych. Professor of Psychiatry and Associate Head of Research and International Affairs, Department of Psychiatry, University of British Columbia, Van- couver, British Columbia, Canada L. Trevor Young, M.D., Ph.D. Professor and Head, Department of Psychiatry, University of British Colum- bia, Vancouver, British Columbia,
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