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PRODUCT INFORMATION BB-22 Item No. 14099 CAS Registry No.: 1400742-42-8 Formal Name: 1-(cyclohexylmethyl)-1H-indole-3- carboxylic acid, 8-quinolinyl ester N Synonym: QUCHIC O MF: C25H24N2O2 FW: 384.5 O Purity: ≥98% Supplied as: A neat solid N Storage: -20°C Stability: ≥3 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Description JWH 018 (Item No. 10900) is a potent synthetic cannabinoid which has been identified in smoking mixtures.1,2 BB-22 is an analog of JWH 018 that is structurally similar to PB-22 (Item No. 14096) and its derivative, 5-fluoro PB-22 (Item No. 14095). Both BB-22 and PB-22 are distinctive in that an 8-hydroxyquinoline replaces the naphthalene group of JWH 018. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications. This product is qualified as a Reference Material that has been manufactured and tested to ISO/IEC 17025 and ISO 17034 international standards. References 1. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200, 141-147 (2010). 2. Moran, C.L., Le, V.H., Chimalakonda, K.C., et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal. Chem. 83(11), 4228-4236 (2011). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 08/12/2019 WWW.CAYMANCHEM.COM.

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PRODUCT INFORMATION FDU-PB-22 Item No
PRODUCT INFORMATION FDU-PB-22 Item No. 14968 CAS Registry No.: 1883284-94-3 F Formal Name: 1-[(4-fluorophenyl)methyl]- 1H-indole-3-carboxylic acid, N O 1-naphthalenyl ester MF: C26H18FNO2 O FW: 395.4 Purity: ≥98% UV/Vis.: λmax: 220, 294 nm Supplied as: A crystalline solid Storage: -20°C Stability: As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly Description Several cannabimimetic quinolinyl carboxylates (PB-22, Item No. 14096 and BB-22, Item No. 14099) and cannabimimetic carboxamide derivatives (ADB-FUBINACA, Item No. 14292 and ADBICA, Item No. 14293) have been identified as designer drugs in illegal products.1 FDU-PB-22 is a derivative of PB-22 in which the pentyl side chain is replaced by a 4-fluorobenzyl group, a functional group also found in indazole-based synthetic cannabinoids such as ADB-FUBINACA. Additionally, the 8-quinolinol is replaced by a naphthalene group, similar to the structure of AM2201(Item No. 10707).1-3 The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications. References 1. Uchiyama, N., Matsuda, S., Kawamura, M., et al. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol. 31(2), 223-240 (2013). 2. Uchiyama, N., Matsuda, S., Wakana, D., et al. New cannabimimetic indazole derivatives, N-(1-amino- 3methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3- methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products.
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Phase I in Vitro Metabolic Profiling of the Synthetic Cannabinoid
H OH metabolites OH Article Phase I In Vitro Metabolic Profiling of the Synthetic Cannabinoid Receptor Agonists CUMYL-THPINACA and ADAMANTYL-THPINACA Manuela Carla Monti , Eva Scheurer and Katja Mercer-Chalmers-Bender * Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, 4056 Basel, Switzerland; [email protected] (M.C.M.); [email protected] (E.S.) * Correspondence: [email protected] Abstract: Synthetic cannabinoid receptor agonists (SCRAs) remain popular drugs of abuse. As many SCRAs are known to be mostly metabolized, in vitro phase I metabolic profiling was conducted of the two indazole-3-carboxamide SCRAs: CUMYL-THPINACA and ADAMANTYL-THPINACA. Both compounds were incubated using pooled human liver microsomes. The sample clean-up consisted of solid phase extraction, followed by analysis using liquid chromatography coupled to a high resolution mass spectrometer. In silico-assisted metabolite identification and structure elucidation with the data-mining software Compound Discoverer was applied. Overall, 28 metabolites were detected for CUMYL-THPINACA and 13 metabolites for ADAMATYL-THPINACA. Various mono-, di-, and tri-hydroxylated metabolites were detected. For each SCRA, an abundant and characteristic di-hydroxylated metabolite was identified as a possible in vivo biomarker for screening methods. Metabolizing cytochrome P450 isoenzymes were investigated via incubation of relevant recombinant liver enzymes. The involvement of mainly CYP3A4 and CYP3A5 in the metabolism of both substances Citation: Monti, M.C.; Scheurer, E.; were noted, and for CUMYL-THPINACA the additional involvement (to a lesser extent) of CYP2C8, Mercer-Chalmers-Bender, K. Phase I In Vitro Metabolic Profiling of the CYP2C9, and CYP2C19 was observed.
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Critical Review Report: ADB-FUBINACA
Critical Review Report: ADB-FUBINACA Expert Committee on Drug Dependence Forty-first Meeting Geneva, 12-16 November 2018 This report contains the views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the World Health Organization 41st ECDD (2018): ADB-FUBINACA © World Health Organization 2018 All rights reserved. This is an advance copy distributed to the participants of the 41st Expert Committee on Drug Dependence, before it has been formally published by the World Health Organization. The document may not be reviewed, abstracted, quoted, reproduced, transmitted, distributed, translated or adapted, in part or in whole, in any form or by any means without the permission of the World Health Organization. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The World Health Organization does not warrant that the information contained in this publication is complete and correct and shall not be liable for any damages incurred as a result of its use.
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Identification of the Novel Synthetic Cannabimimetic 8-Quinolinyl 4-Methyl-3-(1-Piperidinylsulfonyl)Benzoate (QMPSB) and Other D
Forensic Science International 260 (2016) 40–53 Contents lists available at ScienceDirect Forensic Science International jou rnal homepage: www.elsevier.com/locate/forsciint Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense a, b a a,b c Karen Blakey *, Sue Boyd , Sarah Atkinson , Jenna Wolf , Pim M. Slottje , a a Katrina Goodchild , Jenny McGowan a Forensic Chemistry, Queensland Health Forensic and Scientific Services, Brisbane, Australia b Magnetic Resonance Facility, School of Natural Sciences, Griffith University, Brisbane, Australia c Saxion University of Applied Sciences, the Netherlands A R T I C L E I N F O A B S T R A C T Article history: The identification and structural elucidation of the novel synthetic cannabimimetic 8-quinolinyl 4- Received 14 July 2015 methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) by GC-MS, LC-MS and NMR is reported. QMPSB was Received in revised form 21 November 2015 identified in Queensland, Australia on plant material packaged as herbal incense. The identification of Accepted 4 December 2015 QMPSB was initially hampered due to trans-esterification occurring in the extraction solvent. An Available online 14 December 2015 investigation of the trans-esterification of QMPSB in methanol and ethanol was conducted and analytical data for the respective methyl and ethyl esters are reported. Analytical data is presented for two other Keywords: compounds detected on seized plant material packaged as herbal incense: the synthetic cannabimimetic 8-Quinolinyl 4-methyl-3-(1- 1-[(N-methylpiperidin-2-yl)methyl]-3-(4-methyl-1-naphthoyl)indole (MAM-1220) and the JWH-081 piperidinylsulfonyl)benzoate (QMPSB) analogue 1-(cyclohexylmethyl)-3-(4-methoxy-1-naphthoyl)indole (CHM-081).
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1 Councilmember Charles Allen 2 3 4 5 a BILL
1 ___________________________ 2 Councilmember Charles Allen 3 4 5 6 A BILL 7 8 _____ 9 10 11 IN THE COUNCIL OF THE DISTRICT OF COLUMBIA 12 13 __________ 14 15 16 To amend, on an emergency basis, due to congressional review, the District of Columbia 17 Uniform Controlled Substances Act of 1981 to add certain classes and substances to the 18 list of Schedule I controlled substances. 19 20 BE IT ENACTED BY THE COUNCIL OF THE DISTRICT OF COLUMBIA, That this 21 act may be cited as the “Revised Synthetics Abatement and Full Enforcement Drug Control 22 Congressional Review Emergency Amendment Act of 2018”. 23 Sec. 2. The District of Columbia Uniform Controlled Substances Act of 1981, 24 effective August 5, 1981 (D.C. Law 4-29; D.C. Official Code § 48-901.01 et seq.), is amended as 25 follows: 26 (a) Section 102(27) (D.C. Official Code § 48-901.02(27)) is amended as follows: 27 (1) Strike the phrase “as used in section 204(3) and section 206(1)(D)” and insert 28 the phrase “as used in section 204(3), (5), and (6) and section 206(1)(D)” in its place. 29 (2) Strike the phrase “As used in section 204(3)” and insert the phrase “As used in 30 section 204(3), (5), and (6)” in its place. 31 (b) Section 204 (D.C. Official Code § 48-902.04) is amended as follows: 32 (1) Paragraph (3) is amended as follows: 1 33 (A) The lead-in language is amended by striking the phrase “(for purposes 34 of this paragraph only, the term “isomer” includes the optical, position, and geometric isomers):” 35 and inserting a colon in its place.
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In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity
H OH metabolites OH Article In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity Matthias J. Richter 1 , Lea Wagmann 1 , Tanja M. Gampfer 1, Simon D. Brandt 2 and Markus R. Meyer 1,* 1 Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacologyand Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany; [email protected] (M.J.R.); [email protected] (L.W.); [email protected] (T.M.G.) 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK; [email protected] * Correspondence: [email protected]; Tel.: +49-6841-16-26438 Abstract: Quinolin-8-yl 4-methyl-3-(piperidine-1-sulfonyl)benzoate (QMPSB) and quinolin-8-yl 4- methyl-3-(piperidine-1-carbonyl)benzoate (QMPCB, SGT-11) are synthetic cannabinoid receptor agonists (SCRAs). Knowing their metabolic fate is crucial for the identiﬁcation of toxicological screening targets and to predict possible drug interactions. The presented study aimed to identify the in vitro phase I/II metabolites of QMPSB and QMPCB and to study the contribution of different monooxygenases and human carboxylesterases by using pooled human liver S9 fraction (pHLS9), re- combinant human monooxygenases, three recombinant human carboxylesterases, and pooled human liver microsomes. Analyses were carried out by liquid chromatography high-resolution tandem mass Citation: Richter, M.J.; Wagmann, L.; spectrometry. QMPSB and QMPCB showed ester hydrolysis, and hydroxy and carboxylic acid prod- Gampfer, T.M.; Brandt, S.D.; Meyer, M.R. In Vitro Metabolic Fate of the ucts were detected in both cases.
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Simple Screening Procedure for 72 Synthetic Cannabinoids in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry
Forensic Toxicology https://doi.org/10.1007/s11419-017-0401-x ORIGINAL ARTICLE Simple screening procedure for 72 synthetic cannabinoids in whole blood by liquid chromatography–tandem mass spectrometry Katarzyna Ambroziak1 · Piotr Adamowicz1 Received: 11 October 2017 / Accepted: 23 December 2017 © The Author(s) 2018. This article is an open access publication Abstract Purpose In recent years, many synthetic cannabinoids (SCs) have appeared on the drug market. Despite the increasing number of SCs, there are few comprehensive screening methods for their detection in biological specimens. In this context, the purpose of this study was to develop a fast and simple liquid chromatography–tandem mass spectrometry screening procedure for detection and identifcation of SCs in whole blood. Methods The elaborated qualitative screening method allows the simultaneous detection and identifcation of 72 compounds from diferent chemical groups: naphthoylindoles, naphthoylindazoles, benzoylindoles, phenylacetylindoles, tetramethylcy- clopropylindoles, indole-3-carboxylic acid esters, indole-3-carboxylic acid amides, indazole-3-carboxylic acid amides, and others. Whole-blood samples (0.2 mL) were precipitated with acetonitrile (0.6 mL). The separation was achieved with the gradient of the mobile phase composition (0.1% formic acid in acetonitrile and 0.1% formic acid in water) and the gradient of the fow rate (0.5–0.8 mL/min) in 16 min. Detection of all compounds was based on dynamic multiple reaction monitoring. Results Mass spectrometer parameters for all compounds were presented. All of the compounds were well-separated by their retention times and/or transitions. The limits of detection (LODs) for 50 compounds were in the range 0.01–0.48 ng/mL.
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Neurochemical and Neuropharmacological Studies on a Range Of
Neurochemical and Neuropharmacological Studies on a Range of Novel Psychoactive Substances by Barbara Loi Dissertation Submitted to the University of Hertfordshire in partial fulfilment of the requirements of the degree of Doctor of Philosophy Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit Hertfordshire, UK School of Life and Medical Sciences University of Hertfordshire Date: November 2017 1 Table of contents Table of contents ..................................................................................................................................... 2 List of figures .......................................................................................................................................... 6 List of tables .......................................................................................................................................... 10 Aknowledgements ................................................................................................................................. 11 List of abbreviations ............................................................................................................................. 12 Abstract ................................................................................................................................................. 14 Aims, objectives and hypotheses of the overall PhD project ................................................................ 17 Chapter 1: Novel Psychoactive Substances (NPS) ..............................................................................
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This Document Is the Accepted Manuscript Version of a Published Work That Appeared in Final Form in ACS Chemical Neuroscience, Copyright © American
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Neuroscience, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00107 The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB- PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA Samuel D. Banister,a,b Michael Moir,b Jordyn Stuart,c Richard C. Kevin,d Katie E. Wood,d Mitchell Longworth,b Shane M. Wilkinson,b Corinne Beinat,a,b Alexandra S. Buchanan,e,f Michelle Glass,g Mark Connor,c Iain S. McGregor,d Michael Kassioub,h* aDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA; bSchool of Chemistry, The University of Sydney, NSW 2006, Australia; cFaculty of Medicine and Health Sciences, Macquarie University, NSW 2109, Australia; dSchool of Psychology, The University of Sydney, NSW 2006, Australia; eCenter for Immersive and Simulation-based Learning, Stanford University School of Medicine, Stanford, CA 94305, USA; fDepartment of Anaesthesia, Prince of Wales Hospital, Randwick, NSW 2031, Australia; gSchool of Medical Sciences, The University of Auckland, Auckland 1142, New Zealand; hFaculty of Health Sciences, The University of Sydney, NSW 2006, Australia. Keywords: cannabinoid, THC, JWH-018, FUBINACA, PINACA 1 Abstract: Synthetic cannabinoid (SC) designer drugs based on indole and indazole scaffolds and featuring L-valinamide or L-tert-leucinamide side-chains are encountered with increasing frequency by forensic researchers and law enforcement, and are associated with serious adverse health effects.
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Dissertation Submitted As Part of the Requirement for the Bsc Forensic Science
Faculty of Science & Technology An assessment of the effects synthetic cannabinoids can have on a person’s ability to drive A dissertation submitted as part of the requirement for the BSc Forensic Science Ellis George May 2017 Abstract Cannabis is one of the most commonly used drugs for its euphoric effects but due to its psychotropic effects it has been categorised as a Class B drug. As cannabis became illegal many people turned to what they believed to be a safe legal alternative to cannabis. Because of this reason synthetic cannabinoids emerged into the market. These are man-made chemicals that mimic the effects of cannabis. Although they were classed as ‘legal’ they were not necessarily safe. As cannabis was one of the most common drugs used found in driving cases this dissertation aimed to look at synthetic cannabinoids and the effect they have on a persons’ ability to drive. To do this a series of monographs will describe the occurrence and usage, blood concentration, metabolism and excretion, toxicity and the use of synthetic cannabinoids in driving under the influence cases. Identifying the relevant specific synthetic cannabinoids in the literature and extracting the related information that is reported created these monographs. The information collected provides evidence that synthetic cannabinoids cause impairment. Using standardised field sobriety tests, clues were noted by drug recognition experts that indicated impairment for the suspects. Blood concentrations in the related cases were reported to suggest what kind of concentration could produce that level and kind of impairment. Each monograph produced, details the effects that the relevant synthetic cannabinoid has on impairment and the person’s ability to drive.
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PRODUCT INFORMATION ADBICA N-(5-Hydroxypentyl) Metabolite Item No
PRODUCT INFORMATION ADBICA N-(5-hydroxypentyl) metabolite Item No. 15060 Formal Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1- (5-hydroxypentyl)-1H-indole-3-carboxamide Synonym: ADB-PICA N-(5-hydroxypentyl) metabolite MF: C H N O 20 29 3 3 N OH FW: 359.5 O Purity: ≥98% O N H NH UV/Vis.: λmax: 218, 291 nm 2 Supplied as: A crystalline solid Storage: -20°C Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Description ADBICA (Item No. 14293) is a synthetic cannabinoid (CB) that has been identified in herbal blends.1 Although the physiological properties of this compound are not known, its aminoalkylindole base is similar to that of other cannabimimetics that potently activate both CB receptors.2 ADBICA N-(5-hydroxypentyl) metabolite is an expected metabolite of ADBICA, based on the metabolism of similar compounds.3 The physiological and toxicological properties of this compound have not been determined. This product is intended for forensic and research applications. References 1. Uchiyama, N., Matsuda, S., Kawamura, M., et al. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative a-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol. 31(2), 223-240 (2013). 2. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding.
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Controlled Substances List (Adopted by Alabama State Board of Health on January 20, 2021, Effective January 20, 2021)
1 Controlled Substances List (Adopted by Alabama State Board of Health on January 20, 2021, effective January 20, 2021) Schedule I (a) Schedule I shall consist of the drugs and other substances, by whatever official name, common or usual name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. (b) Opiates. Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation (for purposes of 3-methylthiofentanyl only, the term isomer includes the optical and geometric isomers): (1) Acetyl-alpha-methylfentanyl (N-[1-[1-methyl-2-phenethyl]-4-piperidinyl]- N-phenylacetamide -------------------------------------------------------------------- 9815 (Federal Control Nov. 29, 1985; State Dec. 29, 1985) (2) Acetylmethadol ------------------------------------------------------------------------- 9601 (3) AH-7921 (3,4-dichloro-N-[(1-dimethylamino)cyclohexylmethyl] benzamide -------------------------------------------------------------------------------- 9551 Federal Control May 16, 2016; State June 15, 2016 (4) Allylprodine ----------------------------------------------------------------------------- 9602 (5) Alphacetylmethadol --------------------------------------------------------------------- 9603 (6) Alphameprodine
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