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Poster Presentations Ann Rheum Dis 2001;60:ii17–ii52 ii17 Ann Rheum Dis: first published as 10.1136/ard.60.90002.ii17 on 1 October 2001. Downloaded from Poster presentations P001 ASSOCIATION OF CHRONIC OLIGOARTHRITIS WITH expression: CD3: before 1.5 ± 0.5 vs after 1.0 ± 0.0; CD4: 1.5 ± 0.5 vs HLA CLASS II ALLELES: DRB1, DQB1 AND DQA1 IN 0.5 ± 0.5; CD8: 1.5 ± 0.5 vs 0.5 ± 0.5 ; CD38: 0.5 ± 0.5 vs 0.5 ± 0.5; BULGARIAN CHILDREN CD68 in the intimal lining layer: 2.5 ± 0.5 vs 0.5 ± 0.5; CD55: 1.0 ± 0.0 vs 1.5 ± 0.5; TNF-á: 3.0 ± 0.0 vs 1.0 ± 0.0 ; IL-1b: 2.0 ± 1.0 vs 1.0 I. N. Boykinov1, S. Stefanov1,N.Ivanova1, A. Telcharova1, D. Michailova1, ± 0.0; and IL-6: 1.5 ± 0.5 vs 0.5 ± 0.5. The percentages CD45RO+ K. Lisichki1,M.Ivanova2, D. Baltadjieva2, E.Naumova2. 1Pediatric Clinic of memory T-cells in patient 1 were also reduced after therapy. Reumathology, Chair of Pediatrics; 2Central Laboratory of Clinical Immunology, Semiquantitative scores for CD55+FLS and CD38 + plasma cells Medical University Sofia, Bulgaria. were not decreased after therapy. Conclusion: Clinical improvement after ASCT in JIA patients is associated with reduced synovial inflammation and a decrease in pro- HLA class II alleles (DRB1, DQB1 and DQA1) were investigated in inflammatory cytokine expression. 20 Bulgarian children (12 girls and 8 boys) with Juvenile chronic idi- opathic oligoarthritis. Our patients are in age from 1.5 to 12 years (mean age 5.2 years). All they have minimal or moderate P003 EFFECTS OF DEXAMETHASONE ON inflammatory activity based on clinical symptoms, ESR, CRP, DIFFERENTIATION AND MATRIX MINERALIZATION IN RF-negative. Eight of the patients (all girls) have chronic anterior CULTURED GROWTH PLATE CHONDROCYTES uveitis and positive ANA. In evolution of 1.5 to 2 years the patients remained in oligoarthritic type of JIA. C. Brochhausen, K. Grefe, P. Tsompanis, J. Benders, R. Nüsing, G. Klaus. The control group included 130 unrelated healthy individuals from Department of Paediatrics, Philipps-University, Marburg, Germany. the Bulgarian population without family history of autoimmune disease. Genomic DNA from JIA children and the controls was extracted Introduction: Long-term treatment with glucocorticoid leads to from whole venous blood using the standard salting-out method. growth retardation. In vitro data suggest direct eVects of glucocorti- HLA-DRB1,-DQB1 and –DQA1 genotyping was performed by coids on growth plate chondrocytes. Since growth is the result of cell PCR-SSP method. 13 HLA-DRB1, 6 DQB1 and 10 DQA1 allele proliferation and –diVerentiation, the aim of the present study was to groups were found in the patients and controls. Statistically significant investigate the eVects of dexamethason on these pathways crucial for predisposing association was established for DRB1*08 (OR=4.02, normal growth plate function. p<0.05), DQB1*04 (OR=3.50, p<0.05) and DQA1*0401 Methods: Isolated chondrocytes from rat tibial growth plates were (OR=4.02, p<0.05). Although no diVerence in allele association was cultured as monolayer and three-dimensional cell-pellets. Cultures -7 observed in children with and without eye involvement, in these with were treated with dexamethason (10 M) for 21 days. Cell prolifera- chronic anterior uveitis the frequency of alleles mentioned was higher. tion was measured by pellet-weight and DNA-content. As marker for These alleles show strong linkage disequilibrium and the same cell diVerentiation Collagen I, II, X and osteocalcin were analysed via association has been found in all clinical types of JIA within the 12th RT-PCR. The extent of mineralization was analysed by van-Kossa IHWCS . staining. Conclusion: Our data confirm predisposing JCA associations Results: Dexamethason inhibited significantly the cell prolifera- found in other Caucasian populations. Since the same HLA class II tion measured by an DNA content. Total protein amount was slightly association was found in children with and without eye uveitis, reduced under dexamethason. However, protein normalized for patients without eye involvement are not safeguarded against develop- DNA, was increased three fold in dexamethason treated cells (7,6µg ment of uveitis. vs. 22,7 µg /ng DNA). The expression of Collagen I, II and X meas- ured as Col/â-actin ratio were reduced about 63, 44, 42% respectively. No influence on osteocalcin expression was detectable. Mineralization was dramatically reduced after 21 days of Dexamethason. http://ard.bmj.com/ P002 DECREASE IN CELLULARITY AND CYTOKINE Discussion: Dexamethason inhibited cell proliferation and cell EXPRESSION BY AUTOLOGOUS STEM CELL diVerentiation of cultured growth plate chondrocytes. The question TRANSPLANTATION (ASCT) IN PATIENTS WITH wether the increased amount of protein per cell could be explained by JUVENILE IDIOPATHIC ARTHRITIS (JIA) increased synthesis or reduced decomposition needs further investiga- tions. D. M. C. Brinkman1, T. J. M. Smeets2, R. ten Cate1, M. C. Kraan2,P.P. Ta k 2 . 1 Leiden University Medical Center, Leiden; 2Academic Medical Center, Amsterdam, Netherlands. P004 SYNOVIAL MEMBRANE EXPRESSION OF MATRIX METALLO-PROTEINASES AND THEIR TISSUE on September 25, 2021 by guest. Protected copyright. Objective: ASCT has been used as an experimental treatment in INHIBITOR (TIMP-1) IN JIA refractory JIA. The aim of this study was to analyze the eVects of 1 2 1 3 3 ASCT at the site of inflammation. Therefore, we examined the M. Gattorno , V.Gerloni , P. Picco , A. Morando , F. Comandini ,M.Gat- 2 1 2 3 1 nd changes in the cellular infiltrate and the expression of pro- tinara , A. Buoncompagni , F. Fantini , C. Gambini . 2 Division of Paedi- 3 inflammatory cytokines in the synovium in relation to clinical eVects atrics (Rheumatology Unit); Department of Pathology, “G. Gaslini” Scientific 2 of ASCT. Institute for Children, Genoa; Chair of Rheumatology, University of Milan, Methods: JIA patients were treated with T-cell depleted ASCT Italy. after a conditioning regimen consisting of antithymocyte globuline, cyclophosphamide and total body irradiation. Synovial biopsies were Matrix metalloproteinases (MMPs) are a large family of proteolytic obtained by needle arthroscopy in two JIA patients aged 14 and 5 enzymes involved in the remodelling of extracellular matrix in many years (one systemic and one polyarticular) before and six months after physiological and pathological conditions. TIMP-1 is the major natu- ASCT. Immunohistochemical analysis was performed using mono- ral inhibitor of MMPs. Aim of the study was to investigate the syno- clonal antibodies to detect CD3+ T-cells, CD4+ T-cells, CD8+ vial membrane (SM) expression of MMP-1, MMP-3, MMP-13 and T-cells,CD38+ plasma cells, CD55+ fibroblast-like synoviocytes, and TIMP-1 in JIA. CD68+ macrophages, as well as the expression of pro-inflammatory Patients and Methods: SM obtained at synoviectomy or arthro- cytokines IL-1â, IL-6, and TNF-á. Stained sections were examined plasty from 9 JIA patients were studied. SM from an adult RA patient by semiquantitative analysis (0-4). Double immunofluorescence was and from a 13-year old girl who underwent post-traumatic meniscec- performed to determine CD3+/ CD45RO+ and CD8+CD45RO+ tomy were also studied. Immunohistochemical study was performed cells. Results before and after ASCT were compared in relation to according to standard technique. The following monoclonal antibod- clinical outcome. ies were used: anti-CD68 (Dako, Denmark), anti- MMP-1, -MMP-3, Results: ASCT was well tolerated in both patients. Aplastic -MMP-13, -TIMP-1 (Chemicon International, Canada). Slides were periods lasted for 18 days. Lymphocytopenia (CD3 <500/ul) lasted evaluated by 2 expert pathologists unaware of diagnosis according to for 30 days. Follow-up showed a marked decrease in arthritis severity the number of positive cells/high power field (hpf/40x). as expressed in core set criteria for JIA after 3 and after 6 months. Results: n JIA patients and RA control, MMP-1 and MMP-3 dis- Clinical improvement was associated with a decrease in most played a prevalent localization at the level of the lining layers with a semiquantitative scores for synovial inflammation and cytokine high correlation (Spearman’s rank test) with macrophagic infiltration www.annrheumdis.com ii18 Abstracts Ann Rheum Dis: first published as 10.1136/ard.60.90002.ii17 on 1 October 2001. Downloaded from (r = 0.95, p < 0.001; r = 0.83, p = 0.003). MMP-13 was expressed in years at disease onset. In contrast, in children with a disease onset over 8/9 JIA patients and localized almost exclusively to the sublining the age of 5 years an increased frequency of codon 52 mutant alleles areas. TIMP-1 tissue distribution was similar to that observed for is detected. These findings imply that, dependent on the age of onset MMP-1 and –3, even if with a lower intensity of staining. of disease, diVerent infectious triggers are important in susceptibility Conclusion: In JIA overexpression MMP-1 and MMP-3 is clearly to SYS-JIA. related with the degree of synovial inflammation. Inadequate expres- sion of their tissue inhibitors may represent a crucial event for the development and perpetuation of tissue damage. P007 INTRAARTICULAR ALTERATION OF TRYPTOPHAN METABOLISM IN JUVENILE IDIOPATHIC ARTHRITIS MOLECULAR MECHANISMS THAT SHAPE THE P005 M. Metzler1, M Herrmann2, M. Rauh1, R. Wassmuth3, W. Rascher 1,J.P. KAPPA GENE REPERTOIRE OF CD19+ SLE B CELLS Haas4. 1Department of Pediatrics; 2Institute of Clinical Rheumatology— University of Erlangen-Nuremberg; 3Institute for Diagnostics in H. J. Girschick1,2, H. Kränzle1, P. E. Lipsky2. 1 Children’s Hospital, University Transplantation—University of Duesseldorf; 4Department of Pediatrics— of Würzburg, Germany; 2 Harold C. Simmons Arthritis Research Center, University of Greifswald, Germany. Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas, USA.
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