Phlorotannins: from Isolation and Structural Characterization, to The
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Dieckol, a Component of Ecklonia Cava, Suppresses the Production of MDC/CCL22 Via Down-Regulating STAT1 Pathway in Interferon-Γ Stimulated Hacat Human Keratinocytes
Original Article Biomol Ther 23(3), 238-244 (2015) Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes Na-Jin Kang1,†, Dong-Hwan Koo1,†, Gyeoung-Jin Kang2, Sang-Chul Han2, Bang-Won Lee2, Young-Sang Koh1,2, Jin-Won Hyun1,2, Nam-Ho Lee3, Mi-Hee Ko4, Hee-Kyoung Kang1,2 and Eun-Sook Yoo1,2,* Departments of 1Biomedicine & Drug Development, 2Medicine, School of Medicine, 3Chemistry, College of Natural Science, Jeju National University, Jeju 690-756, 4Jeju Biodiversity Research Institute, JejuTechnopark, Jeju 699-943, Republic of Korea Abstract Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22 levels are el- evated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflam- matory lymphocytes to the skin. A major signaling pathway in the interferon-γ (IFN-γ)-stimulated inflammation response involves the signal transducers and activators of transcription 1 (STAT1). In the present study, we investigated the anti-inflammatory effect of dieckol and its possible action mechanisms in the category of skin inflammation including atopic dermatitis. Dieckol inhibited MDC/CCL22 production induced by IFN-γ (10 ng/mL) in a dose dependent manner. Dieckol (5 and 10 mM) suppressed the phos- phorylation and the nuclear translocation of STAT1. These results suggest that dieckol exhibits anti-inflammatory effect via the down-regulation of STAT1 activation. -
Sunscreen, Antioxidant, and Bactericide Capacities of Phlorotannins from the Brown Macroalga Halidrys Siliquosa
1 Journal Of Applied Phycology Achimer December 2016, Volume 28 Issue 6 Pages 3547-3559 http://dx.doi.org/10.1007/s10811-016-0853-0 http://archimer.ifremer.fr http://archimer.ifremer.fr/doc/00366/47682/ © Springer Science+Business Media Dordrecht 2016 Sunscreen, antioxidant, and bactericide capacities of phlorotannins from the brown macroalga Halidrys siliquosa Le Lann Klervi 1, *, Surget Gwladys 1, Couteau Celine 2, Coiffard Laurence 2, Cerantola Stephane 3, Gaillard Fanny 4, Larnicol Maud 5, Zubia Mayalen 6, Guerard Fabienne 1, Poupart Nathalie 1, Stiger-Pouvreau Valerie 1 1 UBO, European Inst Marine Studies IUEM, LEMAR UMR UBO CNRS Ifremer IRD 6539, Technopole Brest Iroise, F-29280 Plouzane, France. 2 Nantes Atlant Univ, Univ Nantes, Fac Pharm, LPiC,MMS,EA2160, 9 Rue Bias,BP 53508, F-44000 Nantes, France. 3 UBO, RMN RPE MS, 6 Ave,Victor Le Gorgeu CS93837, F-29238 Brest 3, France. 4 CNRS, Plateforme Spectrometrie Masse MetaboMER, FR2424, Stn Biol, Pl Georges Teissier,BP 74, F-29682 Roscoff, France. 5 Venelle Carros, Labs Sci & Mer, CS 70002, F-29480 Le Relecq Kerhuon, France. 6 Univ Polynesie Francaise, EIO UMR 244, LabEx CORAIL, BP 6570, Faaa 98702, Tahiti, Fr Polynesia. * Corresponding author : Klervi Le Lann, email address : [email protected] Abstract : The present study focused on a brown macroalga (Halidrys siliquosa), with a particular emphasis on polyphenols and their associated biological activities. Two fractions were obtained by liquid/liquid purification from a crude hydroethanolic extract: (i) an ethyl acetate fraction and (ii) an aqueous fraction. Total phenolic contents and antioxidant activities of extract and both fractions were assessed by in vitro tests (Folin–Ciocalteu test, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, reducing power assay, superoxide anion scavenging assay, and β-carotene–linoleic acid system). -
On Anti-Lipid Peroxidation in Vitro and in Vivo
Research Article Algae 2015, 30(4): 313-323 http://dx.doi.org/10.4490/algae.2015.30.4.313 Open Access Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo Ji-Hyeok Lee1, Ju-Young Ko1, Jae-Young Oh1, Eun-A Kim1, Chul-Young Kim2 and You-Jin Jeon1,* 1Department of Marine Life Science, Jeju National University, Jeju 63243, Korea 2Natural Product Research Center, Hanyang University, Ansan 15588, Korea Lipid peroxidation means the oxidative degradation of lipids. The process from the cell membrane lipids in an organ- ism is generated by free radicals, and result in cell damage. Phlorotannins, well-known marine brown algal polyphenols, have been utilized in functional food supplements as well as in medicine supplements to serve a variety of purposes. In this study, we assessed the potential anti-lipid peroxidation activity of phlorofucofuroeckol-A (PFF-A), one of the phlo- rotannins, isolated from Ecklonia cava by centrifugal partition chromatography in 2,2-azobis (2-amidinopropane) dihy- drochloride (AAPH)-stimulated Vero cells and zebrafish system. PFF-A showed the strongest scavenging activity against alkyl radicals of all other reactive oxygen species (ROS) and exhibited a strong protective effect against ROS and a signifi- cantly strong inhibited of malondialdehyde in AAPH-stimulated Vero cells. The apoptotic bodies and pro-apoptotic pro- teins Bax and caspase-3, which were induced by AAPH, were strongly inhibited by PFF-A in a dose-dependent manner and expression of Bcl-xL, an anti-apoptotic protein, was induced. In the AAPH-stimulated zebrafish model, additionally PFF-A significantly inhibited ROS and cell death, as well as exhibited a strong protective effect against lipid peroxidation. -
Polyphenols in Cancer Prevention: New Insights (Review)
INTERNATIONAL JOURNAL OF FUNCTIONAL NUTRITION 1: 9, 2020 Polyphenols in cancer prevention: New insights (Review) GIUSI BRIGUGLIO1, CHIARA COSTA2, MANUELA POLLICINO1, FEDERICA GIAMBÒ1, STEFANIA CATANIA1 and CONCETTINA FENGA1 1Department of Biomedical and Dental Sciences and Morpho‑functional Imaging, Occupational Medicine Section, and 2Department of Clinical and Experimental Medicine, University of Messina, I‑98125 Messina, Italy Received July 30, 2020; Accepted September 21, 2020 DOI:10.3892/ijfn.2020.9 Abstract. A huge volume of literature data suggests that a diet Contents rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific 1. Introduction cancers. Resveratrol, epigallocatechin gallate and curcumin 2. Literature search are among the most extensively studied polyphenols: The 3. Classification of polyphenols majority of the effects attributed to these compounds are 4. Prostate cancer linked to their antioxidant and anti‑inflammatory properties. 5. Colon cancer The multiple mechanisms involved include the modulation 6. Breast cancer of molecular events and signaling pathways associated with 7. Lung cancer cell survival, proliferation, differentiation, migration, angio‑ 8. Bladder cancer genesis, hormonal activities, detoxification enzymes and 9. Skin cancer immune responses. Notwithstanding their promising role in 10. Pancreatic cancer cancer prevention and treatment, polyphenols often have a 11. Leukemia poor bioavailability when administered as pure active prin‑ -
The Halogenated Metabolism of Brown Algae
The Halogenated Metabolism of Brown Algae (Phaeophyta), Its Biological Importance and Its Environmental Significance Stéphane La Barre, Philippe Potin, Catherine Leblanc, Ludovic Delage To cite this version: Stéphane La Barre, Philippe Potin, Catherine Leblanc, Ludovic Delage. The Halogenated Metabolism of Brown Algae (Phaeophyta), Its Biological Importance and Its Environmental Significance. Marine drugs, MDPI, 2010, 8, pp.988. hal-00987044 HAL Id: hal-00987044 https://hal.archives-ouvertes.fr/hal-00987044 Submitted on 5 May 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Mar. Drugs 2010, 8, 988-1010; doi:10.3390/md8040988 OPEN ACCESS Marine Drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review The Halogenated Metabolism of Brown Algae (Phaeophyta), Its Biological Importance and Its Environmental Significance Stéphane La Barre 1,2,*, Philippe Potin 1,2, Catherine Leblanc 1,2 and Ludovic Delage 1,2 1 Université Pierre et Marie Curie-Paris 6, UMR 7139 Végétaux marins et Biomolécules, Station Biologique F-29682, Roscoff, France; E-Mails: [email protected] (P.P.); [email protected] (C.L.); [email protected] (L.D.) 2 CNRS, UMR 7139 Végétaux marins et Biomolécules, Station Biologique F-29682, Roscoff, France * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +33-298-292-361; Fax: +33-298-292-385. -
WO 2010/087983 Al
(12) INTERNATIONALAPPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 5 August 2010 (05.08.2010) WO 2010/087983 Al (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A61F 2/00 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/US2010/000257 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 29 January 2010 (29.01 .2010) NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (25) Filing Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/206,391 29 January 2009 (29.01 .2009) US GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, 61/212,722 15 April 2009 (15.04.2009) US ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, 61/271,498 22 July 2009 (22.07.2009) US TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, 61/271,961 29 July 2009 (29.07.2009) US ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, (72) Inventor; and TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant : MOAZED, Kambiz, Thomas [US/US]; ML, MR, NE, SN, TD, TG). -
PDF, Also Known As Version of Record
A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds Ford, L., Theodoridou, K., Sheldrake, G. N., & Walsh, P. J. (2019). A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds. Phytochemical Analysis. https://doi.org/10.1002/pca.2851 Published in: Phytochemical Analysis Document Version: Publisher's PDF, also known as Version of record Queen's University Belfast - Research Portal: Link to publication record in Queen's University Belfast Research Portal Publisher rights Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. General rights Copyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact [email protected]. Download date:24. Sep. 2021 Received: 10 January 2019 Revised: 7 May 2019 Accepted: 7 May 2019 DOI: 10.1002/pca.2851 REVIEW A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds Lauren Ford1 | Katerina Theodoridou2 | Gary N. -
An Emerging Trend in Functional Foods for the Prevention of Cardiovascular Disease and Diabetes: Marine Algal Polyphenols
Critical Reviews in Food Science and Nutrition ISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn20 An emerging trend in functional foods for the prevention of cardiovascular disease and diabetes: Marine algal polyphenols Margaret Murray , Aimee L. Dordevic , Lisa Ryan & Maxine P. Bonham To cite this article: Margaret Murray , Aimee L. Dordevic , Lisa Ryan & Maxine P. Bonham (2016): An emerging trend in functional foods for the prevention of cardiovascular disease and diabetes: Marine algal polyphenols, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2016.1259209 To link to this article: http://dx.doi.org/10.1080/10408398.2016.1259209 Accepted author version posted online: 11 Nov 2016. Published online: 11 Nov 2016. Submit your article to this journal Article views: 322 View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=bfsn20 Download by: [130.194.127.231] Date: 09 July 2017, At: 16:18 CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION https://doi.org/10.1080/10408398.2016.1259209 An emerging trend in functional foods for the prevention of cardiovascular disease and diabetes: Marine algal polyphenols Margaret Murray a, Aimee L. Dordevic b, Lisa Ryan b, and Maxine P. Bonham a aDepartment of Nutrition, Dietetics and Food, Monash University, Victoria, Australia; bDepartment of Natural Sciences, Galway-Mayo Institute of Technology, Galway, Ireland ABSTRACT KEYWORDS Marine macroalgae are gaining recognition among the scientific community as a significant source of Anti-inflammatory; functional food ingredients. -
Eckol Alleviates Intestinal Dysfunction During Suckling-To-Weaning Transition Via Modulation of PDX1 and HBEGF
Eckol alleviates intestinal dysfunction during suckling-to-weaning transition via modulation of PDX1 and HBEGF Sang In Lee ( [email protected] ) Kyungpook National University - Sangju Campus In Ho Kim Dankook University Research Keywords: Barrier function, Eckol, HBEGF, Ethanol extract of dried E. cava Posted Date: April 29th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-25134/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published at International Journal of Molecular Sciences on July 3rd, 2020. See the published version at https://doi.org/10.3390/ijms21134755. Page 1/26 Abstract Background Maintaining intestinal health in livestock is critical during weaning. Although intestinal dysfunction during this period can be alleviated by phlorotannins including eckol, the precise mechanisms are not fully understood. We addressed this question by evaluating changes in gene expression and intestinal function after treatment with eckol during the suckling-to-weaning transition. The biological roles of differentially expressed genes in intestinal development were investigated by assessing intestinal wound healing and barrier function and associated signaling pathways, along with oxidative stress levels. Results We identied 890 differentially expressed genes in the intestine whose expression was altered by eckol treatment including pancreatic and duodenal homeobox (PDX)1, which directly regulate the expression of heparin-binding epidermal growth factor-like growth factor (HBEGF) to preserve intestinal barrier function and promote wound healing via phosphoinositide 3-kinase (PI3K)/AKT and P38 signaling. Additionally, eckol alleviated H2O2-induced oxidative stress via PI3K/AKT, P38, and 5' AMP-activated protein kinase signaling, improved growth, and reduced oxidative stress and intestinal permeability in pigs during weaning. -
Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases
Mar. Drugs 2014, 12, 4934-4972; doi:10.3390/md12094934 OPEN ACCESS marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases Mariana Barbosa, Patrícia Valentão and Paula B. Andrade * REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal; E-Mails: [email protected] (M.B.); [email protected] (P.V.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +351-220428654; Fax: +351-226093390. Received: 18 June 2014; in revised form: 5 September 2014 / Accepted: 15 September 2014 / Published: 25 September 2014 Abstract: Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases. -
Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs
PHCOG J REVIEW ARTICLE Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs G. Phani Kumar*, K.R. Anilakumar and S. Naveen Applied Nutrition Division, Defence Food Research Laboratory (DRDO), Ministry of Defence, India ABSTRACT Many neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease, anxiety, cerebrovascular impairment, depression, seizures, Parkinson's disease, etc. are predominantly appearing in the current era due to the stress full lifestyle. Treatment of these disorders with prolonged administration of synthetic drugs will lead to severe side effects. In the recent years, scientists have focused the attention of research towards phytochemicals to cure neurological disorders. Nootropic herb refers to the medicinal role of various plants/parts for their neuroprotective properties by the active phytochemicals including alkaloids, steroids, terpenoids, saponins, phenolics, flavonoids, etc. Phytocompounds from medicinal plants play a major part in maintaining the brain's chemical balance by acting upon the function of receptors for the major inhibitory neurotransmitters. Medicinal plants viz. Valeriana officinalis, Nardostachys jatamansi, Withania somnifera, Bacopa monniera, Ginkgo biloba and Panax ginseng have been used widely in a variety of traditional systems of therapy because of their adaptogenic, psychotropic and neuroprotective properties. This review highlights the importance of phytochemicals on neuroprotective function and other related disorders, in particular -
Prolonged Exposure of Marine Algal Phlorotannins with Whitening Effect
General Internal Medicine and Clinical Innovations Research Article ISSN: 2397-5237 Prolonged exposure of marine algal phlorotannins with whitening effect did not cause inflammatory hyperpigmentation in zebrafish larva Seon-Heui Cha1, Eun-Ah Kim2, Kil-Nam Kim3, Soo-Jin Heo2, Hee-Sook Jun4-6* and You-Jin Jeon7* 1Department of Marine Bio and Medical Science, Hanseo Universirty, Republic of Korea 2Jeju International Marine Science Center for Research & Education, Korea Institute of Ocean Science & Technology (KIOST), Republic of Korea 3Chuncheon Center, Korea Basic Science Institute (KBSI), Republic of Korea 4College of Pharmacy, Gachon University, Republic of Korea 5Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Republic of Korea 6Gachon Medical and Convergence Institute, Gachon Gil Medical center, Republic of Korea 7School of Marine Biomedical Sciences, Jeju National University, Republic of Korea Abstract The demand for novel melanin synthesis inhibitors is increasing due to the weak effectiveness and unwanted side effects. Thus, marine algae have been studied as sources of inhibitors of melanin synthesis, but it is still unclear whether they will be effective in in vivo. In this study, we investigated whether marine algal phlorotannins including phloroglucinol (PG), ekcol (EK), and dieckol (DK) from Ecklonia cava inhibit melanin synthesis in zebrafish embryos. PG, EK, and DK treatment were found to inhibit melanin synthesis in zebrafish embryos as similar to arbutin, used as a positive control. Interestingly, PG, EK, and DK treatment showed no toxicity, whereas arbutin treatment showed toxicity for long-term exposure. As well, mRNA expression of pro-inflammatory cytokines, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF- α), and cyclooxygenase-2 (COX-2) were increased in arbutin treatment, whereas, the mRNA expression were not altered in PG, EK, and DK treatment by long-tern exposure.