Contents Email:[email protected]

Total Page:16

File Type:pdf, Size:1020Kb

Contents Email:Sarahmontagu@Postmaster.Co.Uk Association of Radical Midwives website: www.midwifery.org contents email:[email protected] National Co-ordinator editorial Sarah Montagu Thoughts on Transfers 2 16 Wytham Street Oxford, OX1 4SU 01865 248159 articles from Wigan mobile: 07946 392728 Living in Hope, Dot Parry 3 [email protected] A Waterbirth Denied, Deborah Byrne 5 Magazine Co-ordinator Working within an Orthodox Jewish Community, Dot Parry 7 Margaret Jowitt Midwifery and Judaism, Sarah Montagu 8 29 Albert Street Female Genital Mutilation, Deborah Byrne 10 Ventnor Isle of Wight PO38 1EU 01983 853472 articles from elsewhere [email protected] Nitrous Oxide, no laughing matter, Andrea Robertson 13 Telepathy in the Birthing Room, Anna Reeve 19 Membership Struggling in the Dark, Vanessa, student midwife 20 Ishbel Kargar 62 Greetby Hill Homebirth – A Father’s Experience, Christian Stretton 21 Ormskirk L39 2DT Letter to My Mum’s Midwife, Tez 22 tel/fax: 01695 572776 An Unusual Normal Birth, Andrya Prescott 23 [email protected] Creative Midwifery, Andrya Prescott 24 Treasurer and webmistress Linda Wylie business 4 Darley Place National Meeting report 25 Troon KA10 6JQ 01292 316596 news and views gleanings nettalk: transfer experiences 30 Local Groups Co-ordinator Wendy Blackwood breech transfer 32 11 Hazelhurst Grove home criteria 34 Ashton in Makerfield NMC Homebirth Circular 35 Lancs WN4 8RH 01942 205935 local groups 46 [email protected] Press & Publicity Lynn Walcott 01635 578138 [email protected] ARM Helpline Sarah Montagu 01865 248159 07946 392728 copy deadlines The views expressed in this publication Jan 1 for Spring issue are those of individual contributors and Apr 1 for Summer issue are not necessarily those of ARM as a Jul 1 for Autumn issue whole. Oct 1 for Winter issue Information on the events page is limited to basic details. Any further elaboration will be charged for at the usual rate. Advertising is accepted at the discretion typeset on Adobe software by of ARM. Margaret Jowitt ©Published by the 01983 853472 Association of Radical Midwives printed by Orphans Press, Leominster 16 Wytham Street Oxford OX1 4SU ISSN 0961-1479 01568 612460 reg charity no: 1060 525 Summer 2006 ISSUE 109 Midwifery Matters 1 Transferring to What? The ukmidwifery list on yahoo groups is a veritable into play: we humans seem to thrive on the bustle and cornucopia of raw midwifery feeling and wisdom and I gossipy excitement associated with impending disaster. But look forward to reading and gleaning the ukmidwifery list the adrenalin rush doesn’t benefit the woman; she be- for each issue. comes common property, an object of curiosity, and Two threads leapt out at me this time, the first topic cannot escape, she is the focus of threatening attention. I concerned a transfer for undiagnosed breech presentation. wonder whether this mental trauma is at the root of It could be described as ‘from beautifully delighted to crash PTSD? Everyone involved can make a difference in the way section’, and the second topic concerned how independent they behave towards a woman whose labour needs help. midwives are treated by their hospital collagues when The transfer from a quiet peaceful labour in a birth transferring in with a client. centre or at home to a consultant unit can be a nightmare; In the breech transfer account there was a distinct lack contractions often stop altogether and this is also the time of teamwork. The NHS birth centre midwife had prepared when that curious phenomenon of cervical reversal can her client for what would probably happen at the consult- occur. Will this lead to raised eyebrows and disbelief or an ant unit, saying that in all likelihood labour would continue acknowledgment that the woman is in increased need of normally but her client would be in a place where more emotional support? Who should provide her care? The help could be given if needed. But on transfer an emer- person she knows or strangers in a place that was not her gency caesarean was carried out by a registrar with no first choice for labour? Which will be the least stressful? further discussion and the midwife was devastated. All too often a midwife who, only an hour ago was consid- If that same midwife were to encounter another ered competent to deliver a woman alone, is sidelined and undiagnosed breech, a baby that seemed to be descending her client feels abandoned. well, albeit in an unusual presentation, what would she do? It is this sort of scenario which leads to complaints Would she follow the birth centre protocol and transfer, from women. I would hazard a guess that there are more knowing that her client may then have an unnecessary complaints when continuity of care is disrupted than when caesarean section, or would she let normal birth proceed the transferring midwife remains actively involved. We and risk losing her livelihood through not following should be questioning the assumption by some hospitals protocols? that transferring in during labour means handing over care She could ‘do good by stealth’ and pretend that there completely; how much more important it is to maintain wasn’t time to transfer, that the mother was too near continuity of care when a labour is compromised. And delivery to risk a move. (But she’d better make sure the when obstetric intervention is required, the woman still documentation supported her.) If the mother and baby needs her own midwife beside her, to ensure that any did well, she might ‘get away with it’. Her supervisor might consent is informed consent – and obtained in a sensitive consider that she needed a period of supervised practice, manner; and she needs a familiar face beside her. In the and her employers might take her out of the Birth Centre case above it sounded as if a normal breech birth would as an example to others to show that the Trust will not have been possible but the registrar’s fear led to what tolerate insubordination. But if there was a tragic out- might be called the ‘Hannah – Section’ reflex (regardless of come, she might well find herself hauled up before the the fact that Hannah says nothing about undiagnosed NMC. Should she be struck off the Register? Would you breeches). There is a strong case for requiring Trusts strike her off? What would you do in similar circum- automatically to issue honorary contracts to any midwife stances? transferring in precisely to ensure continuity and prevent Transfers in labour set alarm bells ringing for good litigation. reason: the odds in favour of normal birth have lessened If there is an adverse outcome the scapegoating begins. for whatever the physical reason for the transfer; normal The obvious target is the midwife who transferred in. It is birth is less likely at consultant units; the transfer itself will easier to blame her because she is the outsider. She may have interrupted the flow of the labour; and fear will have not even be employed by the Trust. If she is independent entered the equation – fear being a powerful force against and the Trust has no control over her practice, referral to rational behaviour. Even if we have tried to expunge the the NMC may seem a logical step for managers anxious to word ‘failure’ from our midwifery vocabularies, it is difficult be seen to be ‘doing something’. Independent midwives to find another word to put in its place – it is true that the are reported to the NMC almost routinely and yet their woman will not have the birth she had hoped for in the statistics would be the envy of any NHS Trust. Supervision place she had planned. The disappointment of dashed is failing independent midwives and the women they serve hopes remains for the woman and the midwife. It would if it is over-reliant on NMC Fitness to Practise committees. be helpful if the admitting hospital could help alleviate this Are independent and independently minded midwives in their welcome instead of reinforcing the disappointment carrying the can for the failure of the NHS to provide a – and this is possible, there are good transfer stories. safe and welcoming haven for women whose labours need And what you might call the Casualty factor can come some help? Margaret Jowitt 2 Midwifery Matters ISSUE 109 Summer 2006 Working in Hope Dot Parry These are my thoughts and feelings on the way through the I suspect that the re-organisation is connected to the reorganisation of my local maternity services. way that junior doctors will no longer be worked for September 2005 ridiculously long hours. This has the knock on effect of It has been decided by my local strategic health author- making neonatal units hard to staff. There’s also the issue ity that we need to re-organise our maternity and of training for juniors – with a falling birth rate the neonatal services. At present we have 13 sites across doctors are not seeing enough babies come through the Greater Manchester providing maternity care, many of neonatal units to get a firm grounding. which have an on-site neonatal unit. I work at Hope I also suspect that there is a notion that the maternity Hospital which is a maternity unit in Salford, a separate city services can be more efficient if concentrated into bigger but part of Greater Manchester. We have a popular centralised units. I thought we had tried this before and consultant delivery unit, a fabulous neonatal unit and an realised it didn’t work. I thought we were supposed to be amazing alongside birth centre. I’m told that some pio- putting more services within the communities they serve.
Recommended publications
  • 2015-02 Toxicology Rapid Testing Panel
    SOUTH CAROLINA LAW ENFORCEMENT DIVISION NIKKI R. HALEY MARK A. KEEL Governor Chief FORENSIC SERVICES LABORATORY CUSTOMER NOTICE 2015-02 REGARDING TOXICOLOGY RAPID TESTING PANEL August 12, 2015 This notice is to inform the Coroners of South Carolina of a new testing panel available through the SLED Toxicology Department. On Monday, August 17th, the Toxicology Department will begin offering both a Rapid Testing Panel in addition to the already available Expanded Testing Panel. This Rapid Testing Panel is to be utilized in cases where the Expanded Testing Panel is not warranted, specifically where a cause of death has already been established. The Rapid Testing Panel will consist of volatiles analysis, to include, ethanol, acetone, isopropanol and methanol, drug screens, and drug confirmation/quantitation of positive screens. The cases assigned to the Rapid Testing Panel will have an expedited turnaround time. Targeted turn around times will be two weeks for negative cases and six weeks or less for positive cases. While every effort will be made to adhere to these time frames, additional time may be required on occasion due to the nature of postmortem samples. Submitters will be notified if there is a problem with a particular sample. Please see attachment regarding specifically which substances are covered by the Rapid Testing Panel and the Expanded Testing Panel. As always, a detailed case history and list of drugs suspected is appreciated. Rapid Panel and Expanded Panel will be choices available in iLAB. Please contact Lt. Dustin Smith (803-896-7385) with additional questions. ALI-359-T An Accredited Law Enforcement Agency P.O.
    [Show full text]
  • Properties and Units in Clinical Pharmacology and Toxicology
    Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible.
    [Show full text]
  • Pjp3'2001.Vp:Corelventura
    Copyright © 2001 by Institute of Pharmacology Polish Journal of Pharmacology Polish Academy of Sciences Pol. J. Pharmacol., 2001, 53, 253261 ISSN 1230-6002 INFLUENCE OF DOXEPIN USED IN PREEMPTIVE ANALGESIA ON THE NOCICEPTION IN THE PERIOPERATIVE PERIOD. EXPERIMENTAL AND CLINICAL STUDY Jerzy Wordliczek, Marcin Banach, Magdalena Dorazil, Barbara Przew³ocka*,# Department of Anaesthesiology and Intensive Care, 1st Chair of General Surgery of Collegium Medicum, Jagiellonian University, Kopernika 17, PL 31-501 Kraków, Poland, *Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smêtna 12, PL 31-343 Kraków, Poland Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study. J. WORDLI- CZEK, M. BANACH, M. DORAZIL, B. PRZEW£OCKA. Pol. J. Pharma- col., 2001, 53, 253–261. The aim of the present research was to assess in experimental and clini- cal study the influence of doxepin administered intraperitoneally (ip) as pre- emptive analgesia on the nociception in the perioperative period. The pain thresholds for mechanical stimuli were measured in rats. The objective of clinical investigation was to assess the influence of preemptive administra- tion of doxepin on postoperative pain intensity, analgesic requirement in the early postoperative period as well as an assessment of the quality of postope- rative analgesia by the patient. Doxepin injected ip (3–30 mg/kg) dose-dependently increased the pain threshold for mechanical stimuli measured in paw pressure test in rats. Do- xepin injected 30 min before formalin significantly increased the nociceptive threshold in the paw pressure test. In contrast, doxepin injected 240 min before formalin or 10 min after formalin did not change the nociceptive threshold.
    [Show full text]
  • A Textbook of Clinical Pharmacology and Therapeutics This Page Intentionally Left Blank a Textbook of Clinical Pharmacology and Therapeutics
    A Textbook of Clinical Pharmacology and Therapeutics This page intentionally left blank A Textbook of Clinical Pharmacology and Therapeutics FIFTH EDITION JAMES M RITTER MA DPHIL FRCP FMedSci FBPHARMACOLS Professor of Clinical Pharmacology at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK LIONEL D LEWIS MA MB BCH MD FRCP Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School and the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA TIMOTHY GK MANT BSC FFPM FRCP Senior Medical Advisor, Quintiles, Guy's Drug Research Unit, and Visiting Professor at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK ALBERT FERRO PHD FRCP FBPHARMACOLS Reader in Clinical Pharmacology and Honorary Consultant Physician at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK PART OF HACHETTE LIVRE UK First published in Great Britain in 1981 Second edition 1986 Third edition 1995 Fourth edition 1999 This fifth edition published in Great Britain in 2008 by Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK, 338 Euston Road, London NW1 3BH http://www.hoddereducation.com ©2008 James M Ritter, Lionel D Lewis, Timothy GK Mant and Albert Ferro All rights reserved. Apart from any use permitted under UK copyright law, this publication may only be reproduced, stored or transmitted, in any form, or by any means with prior permission in writing of the publishers or in the case of reprographic production in accordance with the terms of licences issued by the Copyright Licensing Agency.
    [Show full text]
  • LESLEY ANN PAGE Phd Msc BA RN RM Hon Dsc HFRCM
    Professor Lesley Page August 2014 Curriculum Vitae LESLEY ANN PAGE PhD MSc BA RN RM Hon DSc HFRCM E-mail: [email protected] PROFESSIONAL AND ACADEMIC QUALIFICATIONS 2013 Honorary Doctor of Science (Hon DSc) University of West London 2008 Expert Witness Certificate Cardiff Law School University of Cardiff Wales 2007 Honorary Fellow Royal College of Midwives - (conferred in recognition of my outstanding contribution to midwifery) 2005 Doctor of Philosophy – University of Technology Sydney Australia 2008 Registered Midwife BC Canada 1994 Registered Midwife/Teacher 1994 Supervisor of Midwives – North Thames, L.S.A 1988 Supervisor of Midwives – Oxford L.S.A. 1978 Master of Science – University of Edinburgh, Scotland 1978 Registered Nurse Teacher – Scotland 1977 Registered Nurse – British Columbia, Canada 1977 Bachelor of Arts –The Open University, Great Britain 1966 State Certified Midwife – Simpson Memorial Maternity Pavilion, Edinburgh, Scotland 1965 State Registered Nurse – Hammersmith Hospital School of Nursing, London, England. Presented with the Jubilee Award for Nursing. Midwifery and Nursing registration PIN Number: 65Y0687E HONOURS & AWARDS 2014 CBE: Queen’s Birthday Honours List 2013 International Alumni Award 2013, University of Technology Sydney Page 1 of 24 Professor Lesley Page August 2014 PROFESSIONAL EXPERIENCE 2012- President of the Royal College of Midwives 2011-2013 Board Director RCM 2010- Section Leader Midwifery 405 (Clinical Clerkship) University of British Columbia, Canada Midwifery Programme Spring term 2009- Consultant
    [Show full text]
  • Aust Pres 27-2 for Pdfs.Indd
    Does pethidine still have a place in the management of labour pain? Richard W. Watts, Rural General Practitioner, Port Lincoln, South Australia Summary between the median or mean visual analogue pain scores in the pethidine and placebo groups. Pethidine significantly increased Pethidine can provide short-term relief of acute the sedation scores, dizziness, nausea and vomiting.4 pain, but it is not effective for everyone. During labour, intramuscular or intravenous pethidine Comparison with other analgesics sedates women, but may not give them adequate In a randomised controlled trial involving 20 patients in labour, analgesia. Pethidine and its active metabolite, pethidine (up to 1.5 mg/kg) and morphine (up to 0.15 mg/kg) given intravenously produced no significant change in pain norpethidine, can have adverse effects on the scores over time with three doses. Following treatment with neonate as well as the mother, especially if opioids 15 of the patients requested an epidural. Nausea was repeated doses are given during labour. There more common with pethidine (6/10) than with morphine (1/10). is little evidence to show that other drugs have Patients receiving pethidine were calmer and more euphoric, greater efficacy than pethidine, so epidural but both drugs caused similar significant sedation (mean analgesia may be a more effective option. sedation scores 8/10 after three doses). The patients were therefore all significantly sedated and fell asleep during labour, Key words: analgesia, breastfeeding, epidural. but were awakened by pain during contractions. The researchers (Aust Prescr 2004;27:34–5) concluded that labour pain was not sensitive to systemically administered pethidine or morphine and that it was unethical to Introduction treat requests for pain relief by giving sedation.5 Many women prefer to experience birth actively and as naturally Pethidine has also been compared with intravenous fentanyl6, as possible.
    [Show full text]
  • Birth Arts Doula Training Booklist Book List
    Birth Arts Doula Training Booklist Book List - Read the required books from the book list. We require a few more books that most certifying bodies because we feel it is essential to view birth with an open mind and an educated mind. Reading two to three more books can assist in doing this but it also exposes students to different viewpoints and perceptions of the birth process. Book report forms are included in the forms section. Books with an * are required reading. Being a Doula- 3 books *required and then choose 2 additional books. Special Women: The Role of the Professional Paulina Perez* Labor Assistant * The Doula Book: How a Trained Labor Marshall H., M.D. Klaus Companion Can Help You Have a Shorter, Easier, and Healthier Birth The Birth Partner, Second Edition Penny Simkin* Doula: We Couldn't Have Done It without You! Antoinette Bond, Janet M. Graham The Ultimate Guide to Labor Support during Pregnancy and Childbirth The Doula Advantage: Your Complete Guide to Rachel Gurevich Having an Empowered and Positive Birth with the Help of a Professional Childbirth Assistant Mind Over Labor Carl Jones Mothering the Mother: How a Doula Can Help Marshall H. Klaus You Have a Shorter, Easier, and Healthier Birth Doula Programs Paulina Perez The Nurturing Touch at Birth: A Labor Support Paulina Perez Handbook Birth Balls : Use of Physical Therapy Balls in Paulina Perez Maternity Care Special Circumstances 1 book Empty Arms: Hope and Support for Those Who Pam Vredevelt Have Suffered a Miscarriage, Stillbirth, or Tubal Pregnancy Education & Counseling for Childbirth Sheila Kitzinger Expecting Adam: A True Story of Birth, Rebirth, Martha Beck and Everyday Magic Choosing Naia : A Family's Journey Mitchell Zuckoff Ended Beginnings Claudia Panuthos The Bereaved Parent Harriet Sarnoff Schiff Swallowed by a Snake: The Gift of the Masculine Thomas R.
    [Show full text]
  • Urine Drug Tests: How to Make the Most of Them Effective Use of Udts Requires Carefully Interpreting the Results, and Modifying Treatment Accordingly
    Urine drug tests: How to make the most of them Effective use of UDTs requires carefully interpreting the results, and modifying treatment accordingly Xiaofan Li, MD, PhD rine drug tests (UDTs) are useful clinical tools for assessing and Staff Psychiatrist Sioux Falls Veterans Health Care System monitoring the risk of misuse, abuse, and diversion when pre- Assistant Professor scribing controlled substances, or for monitoring abstinence University of South Dakota Sanford School of Medicine U in patients with substance use disorders (SUDs). However, UDTs have Sioux Falls, South Dakota been underutilized, and have been used without systematic documenta- Stephanie Moore, MS tion of reasons and results.1,2 In addition, many clinicians may lack the Toxicologist Richard L. Roudebush VA Medical Center knowledge needed to effectively interpret test results.3,4 Although the Indianapolis, Indiana reported use of UDTs is much higher among clinicians who are mem- Chloe Olson, MD bers of American Society of Addiction Medicine (ASAM), there is still a PGY-4 Psychiatry Resident need for improved education.5 University of South Dakota Sanford School of Medicine Sioux Falls, South Dakota The appropriate use of UDTs strengthens the therapeutic relationship and promotes healthy behaviors and patients’ recovery. On the other hand, incorrect interpretation of test results may lead to missing poten- tial aberrant behaviors, or inappropriate consequences for patients, such Disclosures The authors report no financial relationships with any as discontinuing necessary medications or discharging them from care companies whose products are mentioned in this article, secondary to a perceived violation of a treatment contract due to unex- or with manufacturers of competing products.
    [Show full text]
  • COMPASS Therapeutic Notes on the Use of Strong Opioids in Chronic Non-Cancer Pain
    COMPASS Therapeutic Notes on the use of Strong Opioids in Chronic Non-Cancer Pain Glossary of terms In this issue: Hyperalgesic A paradoxical phenomenon whereby a patient receiving treatment for Page syndrome pain may actually become more sensitive to certain painful stimuli Introduction and background 1 MHRA Medicines and Healthcare products Regulatory Agency Strong opioids in common use 2 Neuropathic pain Pain due to disturbance of the nervous system Less commonly used opioids 4 NNT Number Needed to Treat Adverse effects of opioids 4 Nociceptive pain Pain due to tissue damage; can be either somatic or visceral Opioids in specific conditions 6 RCT Randomised controlled trial Opioids and problem drug use 6 SmPC Summary of Product Characteristics Transdermal opioid patches 7 Pain emanating from muscles, skeleton, skin; pain in the parts of the Somatic pain Practical aspects of prescribing 9 body other than the viscera. Visceral pain Pain relating to any of the large interior organs of the body Successful completion of the assessment questions at the end of this issue will provide you with 2 hours towards your CPD/CME requirements. Further copies of this and any other edition in the COMPASS Therapeutic Notes series, including relevant CPD/CME assessment questions, can be found at: www.centralservicesagency.com/display/compass GPs can complete the multiple choice questions on-line and print off their CPD/CME certificate at: www.medicinesni.com Pharmacists can complete the multiple choice questions on-line and print off their CPD certificate at: www.nicpld.org Introduction and background The use of strong opioids in the Table ONE: Classification of opioids management of cancer pain and Approved name palliative care is widely accepted.
    [Show full text]
  • New Zealand Data Sheet
    NEW ZEALAND DATA SHEET 1. PRODUCT NAME (strength pharmaceutical form) Pethidine, Tablet, 50 mg (PSM) Pethidine, Tablet, 100 mg (PSM) 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Name and strength of the active substance Pethidine Hydrochloride 50 mg Pethidine Hydrochloride 100 mg Excipient(s) with known effect For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Oral – tablet Presentation Pethidine Hydrochloride 50 mg tablets are: round white normal biconvex tablets, 8.0 mm diameter. Pethidine Hydrochloride 100 mg Tablets are: round white normal biconvex tablets, 9.5 mm diameter. Note: Not all product strengths may be marketed. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Pethidine Tablets given orally are indicated for the relief of most types of moderate to severe pain. As it has some antispasmodic activity, it may be the analgesic of choice in renal colic, biliary colic and acute pancreatitis. 4.2 Dose and method of administration Adults: For the relief of pain, Pethidine Tablets given in oral doses of 50 to 150 mg by mouth every 4 hours if necessary. Children: For the relief of pain, 1.1 to 1.76 mg per kg of body weight, not to exceed 100 mg every 3 to 4 hours as needed. (See Special Warnings and Precautions section 4.4). New Zealand Data Sheet Page 1 of 14 NEW ZEALAND DATA SHEET Opioid agonist analgesics may suppress respiration, especially in the very young, elderly, very ill or debilitated patients and those with respiratory problems. Lower doses may be required for these patients. Neonates (see also Pharmacology section 5 and Use in Pregnancy section 4.6) Excretion and metabolism of Pethidine in the neonate is reduced compared with adults.
    [Show full text]
  • LEGISLATIVE ASSEMBLY Question on Notice
    LEGISLATIVE ASSEMBLY Question On Notice Thursday, 15 February 2018 2560. Ms M. M Quirk to the Minister for Police; I refer to the commencement of operation of the Road Traffic Amendment Act 2016 in March 2017 which introduced compulsory blood or urine samples to be taken from drivers involved in serious crashes, and I ask: (a) since March 2017 how many such samples have been taken; (b) for what specific substances are those blood or urine samples tested; (c) what are the results of those tests to date; and (d) what percentage of drivers have been found to have ingested more than one substance capable of impairing driving skills? Answer (a) The compulsory taking of blood from all drivers involved in serious crashes commenced on 10 March 2017. Between 10 March 2017 and 22 February 2018 (inclusive) a total of 398 blood test samples have been collected under the provision of the Road Traffic Amendment Act 2016. There have been no urine tests collected. (b) Please see attached table for a list of substances in blood sample that are identifiable in ChemCentre toxicology analysis (Paper Number). (c) Of the 398 blood samples collected, 48 are pending results of ChemCentre analysis. Of the 350 analysed, 259 samples had a specific substance(s) detected and 91 samples had no specific substance detected. d) Of the 259 samples with specific substance(s) detected, 92% were found to have multiple substances (more than one). Detectable Substances in Blood Samples capable of identification by the ChemCentre WA. ACETALDEHYDE AMITRIPTYLINE/NORTRIPTYLINE
    [Show full text]
  • William D. Hedrich Email: [email protected]
    The Role of the Constitutive Androstane Receptor in Cyclophosphamide-based Treatment of Lymphomas Item Type dissertation Authors Hedrich, William Dominic Publication Date 2018 Abstract Cyclophosphamide (CPA) is an alkylating prodrug which has been utilized extensively in combination chemotherapies for the treatment of cancers and autoimmune disorders since its introduction to the market in the late 1950s. The metabolic conversion o... Keywords constitutive androstane receptor; CYP2B6; drug-drug interactions; Cyclophosphamide; Cytochrome P-450 CYP2B6; Drug Interactions Download date 07/10/2021 19:53:39 Link to Item http://hdl.handle.net/10713/8006 William D. Hedrich Email: [email protected] EDUCATION: Degree Institution Field of Study Date Bachelor of The Pennsylvania State Toxicology 2013 Science University Bachelor of The Pennsylvania State Biology-Vertebrate 2013 Science University Physiology Doctor of University of Maryland, Pharmaceutical 2018 Philosophy Baltimore Sciences ______________________________________________________________________________ RESEARCH EXPERIENCE Graduate Research Assistant Wang Lab, University of Maryland School of Pharmacy • The role of the constitutive androstane receptor in cyclophosphamide-based treatment of lymphomas • Inductive expression of drug metabolizing enzymes and transporters in human primary hepatocytes • Metabolism-mediated drug-drug interactions • In-vivo tumor xenograft models Hassan Lab, University of Maryland School of Pharmacy • Pharmacokinetics of l-THP as an experimental therapy
    [Show full text]