DOI: http://dx.doi.org/10.22034/ari.2016.107493 Archives of Razi Institute, Vol. 72, No. 1 (2017) 23-31 Copyright © 2017 by Razi Vaccine & Serum Research Institute Original Article Effects of experimental Mesobuthus eupeus scorpion envenomation on chicken Khosravi ∗∗∗ 1, M., Mayahi 2 , M., Jalali 2 , S.M., Rezaie 1 , A., Taghavi Moghadam 3 , A., Hosseini 4 , Z., Barzegar 4 , S.K., Azadmanesh 4,S. 1. Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Khuzestan, Iran 2. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Khuzestan, Iran 3. Razi Reference Laboratory of Scorpion Research, Razi Vaccine and Serum Research Institute, Ahvaz, Iran 4. Student of Veterinary Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Khuzestan, Iran Received 13 January 2016; accepted 24 April 2016 Corresponding Author:
[email protected] ABSTRACT This study aimed to evaluate the clinical, histopathological and hematological effects of Mesobuthus eupeus venom on chicken organs. Adult chickens were subcutaneously injected with five doses of M. eupeus venom (0.5, 2, 5, 10 and 20 mg/kg; four chickens per each dose). Symptoms were recorded during the experiment and blood samples were collected for hematological analysis. Moreover, a complete necropsy was performed. After macroscopic examination, tissue samples were obtained from the liver, kidneys, heart, lungs, intestines and brain of the chickens three days after venom administration. In intravenous injection, lethal dose of the venom was determined at 15 mg/kg. The first clinical, pathological and hematological symptoms in envenomated chickens were observed at M.