Multicenter Study of Immunoscintigraphy with Radiolabeled Monoclonal Antibodies in Patients with Melanoma1
[CANCER RESEARCH 46, 4817-4822, September 1986] Multicenter Study of Immunoscintigraphy with Radiolabeled Monoclonal Antibodies in Patients with Melanoma1 A. G. Siccardi,2 G. L. Buraggi, L. Callegaro, G. Mariani, P. G. Natali, A. Abbati, M. Bestagno, V. Caputo, L. Mansi, R. Masi, G. Panini-Ili, P. Riva, M. Salvatore, M. Sanguinati, L. Troncone, G. L. Turco, G. A. Scassettati, and S. Terrone Dipartimento di Biologia e Genetica, Università di Milano, Milano [A. G. S.J; Istituto Nazionale Tumori, Milano fG. L. B.J; Centro Ricerche-SORIN Biomedica, Saluggia [L. C..G.A. S.J; Istituto di Fisiologia ClÃnicadel Consiglio Nazionale delle Ricerche, Pisa [G. M.]; Istituto Tumori Regina Elena, Roma [P. G. N.]; Departments of Nuclear Medicine of Ospedale Maggiore, Bologna [A. A.], Spedali Civili, Brescia [M. B.], Università "La Sapienza", Roma [V. C.], Istituto Pascale, Napoli [L. M., M. Sai.], Ospedale di Careggi, Firenze fR. M.], Ospedale Bufalini-Cesena [G. P., P. R.J, Ospedali Galliera-Genova [M. San.], Università Cattolica, Roma [L. T.], Università di Torino, Torino [G. L. T.], Italy; and Department of Microbiology and Immunology, New York Medical College (S. F.], Valhalla, New York 10595 ABSTRACT in multiple metastatic lesions from different anatomic sites (9); A multicenter study was performed to analyze the efficacy of "Tc- (c) it is undetectable in normal tissues except in hair bulbs and and '"In-labeled F(ab')2 fragments of monoclonal antibody (MoAb) in limited areas of the Malpighian layer (7, 10); (d) it is present only in minute amounts in serum even in patients with advanced 225.28S (reactive with a high molecular weight melanoma associated antigen) to radioimage malignant lesions in patients with melanoma.
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