Vol. 180 No. 4 December 2008

PERSPECTIVES

DENELL, ROB, Establishment of Tribolium as a genetic model system and its early contributions to evo-devo ...... 1779—1786 REVIEW

DRUMMOND-BARBOSA, DANIELA, Stem cells, their niches and the systemic environment: An aging network ...... 1787—1797 INVESTIGATIONS integrity and transmission

REID, ROBERT J. D., IVANA SUNJEVARIC, WARREN P. VOTH, SAMANTHA CICCONE, WENDY DU, AILEEN E. OLSEN, DAVID J. STILLMAN AND RODNEY ROTHSTEIN, -scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae ...... 1799—1808

PALMBOS, PHILLIP L., DONGLIANG WU, JAMES M. DALEY AND THOMAS E. WILSON, Recruitment of Saccharomyces cerevisiae Dnl4–Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain...... 1809—1819

TITEN, SIMON W. A., AND KENT G. GOLIC, Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster...... 1821—1832

MCCUNE, HEATHER J., LAURA S. DANIELSON, GINA M. ALVINO, DAVID COLLINGWOOD, JEFFREY J. DELROW, WALTON L. FANGMAN, BONITA J. BREWER AND M. K. RAGHURAMAN, The temporal program of chromosome replication: Genomewide replication in Clb5⌬ Saccharomyces cerevisiae...... 1833—1847

HOWELL, ELAINE C., MICHAEL J. KEARSEY, GARETH H. JONES, GRAHAM J. KING AND SUSAN J. ARMSTRONG, A and C genome distinction and chromosome identification in napus by sequential fluorescence in situ hybridization and genomic in situ hybridization...... 1849—1857

PARVANOV, EMIL, JUERG KOHLI AND KATJA LUDIN, The mating-type-related bias of gene conversion in Schizosaccharomyces pombe ...... 1859—1868

RONG, YIKANG S., Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila ...... 1869—1875

REDMAN, ELIZABETH, VICTORIA GRILLO, GARY SAUNDERS, ERICA PACKARD, FRANK JACKSON, MATT BERRIMAN AND JOHN STUART GILLEARD, Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus...... 1877—1887

ACHARYA, SONIA N., ALEXANDER M. MANY, ANDREW P. S CHROEDER, FELICIA M. KENNEDY, OLEKSANDR P. S AVYTSKYY, JENNIFER T. G RUBB, JACK A. VINCENT, ELIZABETH A. FRIEDLE, MARTINA CELERIN, DANIEL S. MAILLET, HEATHER J. PALMERINI, MEGAN A. GREISCHAR, GABRIEL MONCALIAN, R. SCOTT WILLIAMS, JOHN A. TAINER AND MIRIAM E. ZOLAN, Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination ...... 1889—1907 Gene expression

KANG, HYUN MIN, CHUN YE AND ELEAZAR ESKIN, Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots ...... 1909—1925

YAMASAKI, TOMOHITO, HITOSHI MIYASAKA AND TAKESHI OHAMA, Unstable RNAi effects through epigenetic silencing of an inverted repeat transgene in Chlamydomonas reinhardtii ...... 1927—1944

WANG, XIAOGANG, HAIMING XU, DONGHONG JU AND YOUMING XIE, Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions...... 1945—1953

WANG, CHIA-LIN, JOSEPH LANDRY AND ROLF STERNGLANZ, A yeast Sir2 mutant temperature sensitive for silencing ...... 1955—1962

SIERA, SCOTT G., AND THOMAS W. CLINE, Sexual back talk with evolutionary implications: Stimulation of the Drosophila sex-determination gene Sex-lethal by its target transformer ...... 1963—1981 SIDORENKO, LYUDMILA, AND VICKI CHANDLER, RNA-dependent RNA polymerase is required for enhancer- mediated transcriptional silencing associated with paramutation at the maize p1 gene ...... 1983—1993

FUTAHASHI, RYO, JOTARO SATO, YAN MENG, SHUN OKAMOTO, TAKAAKI DAIMON, KIMIKO YAMAMOTO, YOSHITAKA SUETSUGU, JUNKO NARUKAWA, HIROKAZU TAKAHASHI, YUTAKA BANNO, SUSUMU KATSUMA, TORU SHIMADA, KAZUEI MITA AND HARUHIKO FUJIWARA, yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori ...... 1995—2005

SPITZNER, ANDREA, ANGELIKA F. PERZLMAIER, KERSTIN E. GEILLINGER, PETRA REIHL AND JÜRGEN STOLZ, The proline- dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae ...... 2007—2017 Cellular genetics

STRADER, LUCIA C., MELANIE MONROE-AUGUSTUS, KRISTEN C. ROGERS, GRACE L. LIN AND BONNIE BARTEL, Arabidopsis iba response5 suppressors separate responses to various hormones...... 2019—2031

MEEDNU, NIDA, HAROLD HOOPS, SONIA D’SILVA, LEAH POGORZALA, SCHUYLER WOOD, DAVID FARKAS, MARK SORRENTINO, ELAINE SIA, PAM MELUH AND RITA K. MILLER, The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae...... 2033—2055

FRANCISCOVICH, A. L., A. D. VRAILAS MORTIMER, A. A. FREEMAN, J. GU AND S. SANYAL, Overexpression screen in Drosophila identifies neuronal roles of GSK-3␤/shaggy as a regulator of AP-1-dependent developmental plasticity ...... 2057—2071

BALESTRA, FERNANDO R., AND JUAN JIMENEZ, A G2-phase microtubule-damage response in fission yeast ...... 2073—2080

BLACHON, STEPHANIE, JAYACHANDRAN GOPALAKRISHNAN, YOSHIHIRO OMORI, ANDREY POLYANOVSKY, ALLEN CHURCH, DANIELA NICASTRO, JAREMA MALICKI AND TOMER AVIDOR-REISS, Drosophila asterless and vertebrate Cep152 are orthologs essential for centriole duplication...... 2081—2094 Developmental and behavioral genetics

MELICHAREK, DAVID, ARPIT SHAH, GINNENE DISTEFANO, ANDREW J. GANGEMI, ANDREW ORAPALLO, ALYSIA D. VRAILAS-MORTIMER AND DANIEL R. MARENDA, Identification of novel regulators of atonal expression in the developing Drosophila retina ...... 2095—2110

KLEEMANN, GUNNAR, LINGYUN JIA AND SCOTT W. EMMONS, Regulation of Caenorhabditis elegans male mate search- ing behavior by the nuclear receptor DAF-12 ...... 2111—2122

JIN, ZHIGANG, ELLEN HOMOLA, STANLEY TIONG AND SHELAGH D. CAMPBELL, Drosophila Myt1 is the major Cdk1 inhibitory kinase for wing imaginal disc development ...... 2123—2133 Population and evolutionary genetics

MARTIN, GUILLAUME, ELODIE CHAPUIS AND JÉROˆ ME GOUDET, Multivariate Q st–Fst comparisons: A neutrality test for the evolution of the G matrix in structured populations ...... 2135—2149

CHAPUIS, ELODIE, GUILLAUME MARTIN AND JÉROˆ ME GOUDET, Effects of selection and drift on G matrix evolution

in a heterogeneous environment: A multivariate Q st–Fst test with the freshwater snail Galba truncatula ...... 2151—2161

FOGLE, CRAIG A., JAMES L. NAGLE AND MICHAEL M. DESAI, Clonal interference, multiple mutations and adap- tation in large asexual populations ...... 2163—2173

DESAI, MICHAEL M., AND JOSHUA B. PLOTKIN, The polymorphism frequency spectrum of finitely many sites under selection...... 2175—2191

HANDEL, ANDREAS, AND MATTHEW R. BENNETT, Surviving the bottleneck: Transmission mutants and the evolu- tion of microbial populations ...... 2193—2200 Genetics of complex traits

XU, SHIZHONG, Quantitative trait locus mapping can benefit from segregation distortion ...... 2201—2208

IBÁÑEZ-ESCRICHE, NOELIA, DANIEL SORENSEN, RASMUS WAAGEPETERSEN AND AGUSTÍN BLASCO, Selection for envi- ronmental variation: A statistical analysis and power calculations to detect response ...... 2209—2226

BURGESS-HERBERT, SARAH L., ALLISON COX, SHIRNG-WERN TSAIH AND BEVERLY PAIGEN, Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci ...... 2227—2235 ROWE, HEATHER C., AND DANIEL J. KLIEBENSTEIN, Complex genetics control natural variation in resistance to Botrytis cinerea...... 2237—2250 Genome and systems biology

ADDINALL, S. G., M. DOWNEY, M. YU, M. K. ZUBKO, J. DEWAR, A. LEAKE, J. HALLINAN, O. SHAW, K. JAMES, D. J. WILKINSON, A. WIPAT, D. DUROCHER AND D. LYDALL, A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae ...... 2251—2266

ASHIKAWA, IKUO, NAGAO HAYASHI, HIROKO YAMANE, HIROYUKI KANAMORI, JIANZHONG WU, TAKASHI MATSUMOTO, KAZUKO ONO AND MASAHIRO YANO, Two adjacent nucleotide-binding site–leucine-rich repeat class genes are required to confer Pikm-specific rice blast resistance...... 2267—2276

CHIANG, CHARLESTON W. K., ADNAN DERTI, DANIEL SCHWARTZ, MICHAEL F. CHOU, JOEL N. HIRSCHHORN AND C.-TING WU, Ultraconserved elements: Analyses of dosage sensitivity, motifs and boundaries 2277—2293 NOTE Genome integrity and transmission

MERCIER, RAPHAEL, SYLVIE JOLIVET, JULIEN VIGNARD, STÉPHANIE DURAND, JAN DROUAUD, GEORGES PELLETIER AND FABIEN NOGUÉ, Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants ...... 2295—2297 REVIEWER INDEX ...... 2299—2307 AUTHOR INDEX ...... 2309—2314 KEYWORD INDEX...... 2315—2321