Vol. 180 No. 4 December 2008
PERSPECTIVES
DENELL, ROB, Establishment of Tribolium as a genetic model system and its early contributions to evo-devo ...... 1779—1786 REVIEW
DRUMMOND-BARBOSA, DANIELA, Stem cells, their niches and the systemic environment: An aging network ...... 1787—1797 INVESTIGATIONS Genome integrity and transmission
REID, ROBERT J. D., IVANA SUNJEVARIC, WARREN P. VOTH, SAMANTHA CICCONE, WENDY DU, AILEEN E. OLSEN, DAVID J. STILLMAN AND RODNEY ROTHSTEIN, Chromosome-scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae chromosomes ...... 1799—1808
PALMBOS, PHILLIP L., DONGLIANG WU, JAMES M. DALEY AND THOMAS E. WILSON, Recruitment of Saccharomyces cerevisiae Dnl4–Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain...... 1809—1819
TITEN, SIMON W. A., AND KENT G. GOLIC, Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster...... 1821—1832
MCCUNE, HEATHER J., LAURA S. DANIELSON, GINA M. ALVINO, DAVID COLLINGWOOD, JEFFREY J. DELROW, WALTON L. FANGMAN, BONITA J. BREWER AND M. K. RAGHURAMAN, The temporal program of chromosome replication: Genomewide replication in Clb5⌬ Saccharomyces cerevisiae...... 1833—1847
HOWELL, ELAINE C., MICHAEL J. KEARSEY, GARETH H. JONES, GRAHAM J. KING AND SUSAN J. ARMSTRONG, A and C genome distinction and chromosome identification in Brassica napus by sequential fluorescence in situ hybridization and genomic in situ hybridization...... 1849—1857
PARVANOV, EMIL, JUERG KOHLI AND KATJA LUDIN, The mating-type-related bias of gene conversion in Schizosaccharomyces pombe ...... 1859—1868
RONG, YIKANG S., Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila ...... 1869—1875
REDMAN, ELIZABETH, VICTORIA GRILLO, GARY SAUNDERS, ERICA PACKARD, FRANK JACKSON, MATT BERRIMAN AND JOHN STUART GILLEARD, Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus...... 1877—1887
ACHARYA, SONIA N., ALEXANDER M. MANY, ANDREW P. S CHROEDER, FELICIA M. KENNEDY, OLEKSANDR P. S AVYTSKYY, JENNIFER T. G RUBB, JACK A. VINCENT, ELIZABETH A. FRIEDLE, MARTINA CELERIN, DANIEL S. MAILLET, HEATHER J. PALMERINI, MEGAN A. GREISCHAR, GABRIEL MONCALIAN, R. SCOTT WILLIAMS, JOHN A. TAINER AND MIRIAM E. ZOLAN, Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination ...... 1889—1907 Gene expression
KANG, HYUN MIN, CHUN YE AND ELEAZAR ESKIN, Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots ...... 1909—1925
YAMASAKI, TOMOHITO, HITOSHI MIYASAKA AND TAKESHI OHAMA, Unstable RNAi effects through epigenetic silencing of an inverted repeat transgene in Chlamydomonas reinhardtii ...... 1927—1944
WANG, XIAOGANG, HAIMING XU, DONGHONG JU AND YOUMING XIE, Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions...... 1945—1953
WANG, CHIA-LIN, JOSEPH LANDRY AND ROLF STERNGLANZ, A yeast Sir2 mutant temperature sensitive for silencing ...... 1955—1962
SIERA, SCOTT G., AND THOMAS W. CLINE, Sexual back talk with evolutionary implications: Stimulation of the Drosophila sex-determination gene Sex-lethal by its target transformer ...... 1963—1981 SIDORENKO, LYUDMILA, AND VICKI CHANDLER, RNA-dependent RNA polymerase is required for enhancer- mediated transcriptional silencing associated with paramutation at the maize p1 gene ...... 1983—1993
FUTAHASHI, RYO, JOTARO SATO, YAN MENG, SHUN OKAMOTO, TAKAAKI DAIMON, KIMIKO YAMAMOTO, YOSHITAKA SUETSUGU, JUNKO NARUKAWA, HIROKAZU TAKAHASHI, YUTAKA BANNO, SUSUMU KATSUMA, TORU SHIMADA, KAZUEI MITA AND HARUHIKO FUJIWARA, yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori ...... 1995—2005
SPITZNER, ANDREA, ANGELIKA F. PERZLMAIER, KERSTIN E. GEILLINGER, PETRA REIHL AND JÜRGEN STOLZ, The proline- dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae ...... 2007—2017 Cellular genetics
STRADER, LUCIA C., MELANIE MONROE-AUGUSTUS, KRISTEN C. ROGERS, GRACE L. LIN AND BONNIE BARTEL, Arabidopsis iba response5 suppressors separate responses to various hormones...... 2019—2031
MEEDNU, NIDA, HAROLD HOOPS, SONIA D’SILVA, LEAH POGORZALA, SCHUYLER WOOD, DAVID FARKAS, MARK SORRENTINO, ELAINE SIA, PAM MELUH AND RITA K. MILLER, The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae...... 2033—2055
FRANCISCOVICH, A. L., A. D. VRAILAS MORTIMER, A. A. FREEMAN, J. GU AND S. SANYAL, Overexpression screen in Drosophila identifies neuronal roles of GSK-3/shaggy as a regulator of AP-1-dependent developmental plasticity ...... 2057—2071
BALESTRA, FERNANDO R., AND JUAN JIMENEZ, A G2-phase microtubule-damage response in fission yeast ...... 2073—2080
BLACHON, STEPHANIE, JAYACHANDRAN GOPALAKRISHNAN, YOSHIHIRO OMORI, ANDREY POLYANOVSKY, ALLEN CHURCH, DANIELA NICASTRO, JAREMA MALICKI AND TOMER AVIDOR-REISS, Drosophila asterless and vertebrate Cep152 are orthologs essential for centriole duplication...... 2081—2094 Developmental and behavioral genetics
MELICHAREK, DAVID, ARPIT SHAH, GINNENE DISTEFANO, ANDREW J. GANGEMI, ANDREW ORAPALLO, ALYSIA D. VRAILAS-MORTIMER AND DANIEL R. MARENDA, Identification of novel regulators of atonal expression in the developing Drosophila retina ...... 2095—2110
KLEEMANN, GUNNAR, LINGYUN JIA AND SCOTT W. EMMONS, Regulation of Caenorhabditis elegans male mate search- ing behavior by the nuclear receptor DAF-12 ...... 2111—2122
JIN, ZHIGANG, ELLEN HOMOLA, STANLEY TIONG AND SHELAGH D. CAMPBELL, Drosophila Myt1 is the major Cdk1 inhibitory kinase for wing imaginal disc development ...... 2123—2133 Population and evolutionary genetics
MARTIN, GUILLAUME, ELODIE CHAPUIS AND JÉROˆ ME GOUDET, Multivariate Q st–Fst comparisons: A neutrality test for the evolution of the G matrix in structured populations ...... 2135—2149
CHAPUIS, ELODIE, GUILLAUME MARTIN AND JÉROˆ ME GOUDET, Effects of selection and drift on G matrix evolution
in a heterogeneous environment: A multivariate Q st–Fst test with the freshwater snail Galba truncatula ...... 2151—2161
FOGLE, CRAIG A., JAMES L. NAGLE AND MICHAEL M. DESAI, Clonal interference, multiple mutations and adap- tation in large asexual populations ...... 2163—2173
DESAI, MICHAEL M., AND JOSHUA B. PLOTKIN, The polymorphism frequency spectrum of finitely many sites under selection...... 2175—2191
HANDEL, ANDREAS, AND MATTHEW R. BENNETT, Surviving the bottleneck: Transmission mutants and the evolu- tion of microbial populations ...... 2193—2200 Genetics of complex traits
XU, SHIZHONG, Quantitative trait locus mapping can benefit from segregation distortion ...... 2201—2208
IBÁÑEZ-ESCRICHE, NOELIA, DANIEL SORENSEN, RASMUS WAAGEPETERSEN AND AGUSTÍN BLASCO, Selection for envi- ronmental variation: A statistical analysis and power calculations to detect response ...... 2209—2226
BURGESS-HERBERT, SARAH L., ALLISON COX, SHIRNG-WERN TSAIH AND BEVERLY PAIGEN, Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci ...... 2227—2235 ROWE, HEATHER C., AND DANIEL J. KLIEBENSTEIN, Complex genetics control natural variation in Arabidopsis thaliana resistance to Botrytis cinerea...... 2237—2250 Genome and systems biology
ADDINALL, S. G., M. DOWNEY, M. YU, M. K. ZUBKO, J. DEWAR, A. LEAKE, J. HALLINAN, O. SHAW, K. JAMES, D. J. WILKINSON, A. WIPAT, D. DUROCHER AND D. LYDALL, A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae ...... 2251—2266
ASHIKAWA, IKUO, NAGAO HAYASHI, HIROKO YAMANE, HIROYUKI KANAMORI, JIANZHONG WU, TAKASHI MATSUMOTO, KAZUKO ONO AND MASAHIRO YANO, Two adjacent nucleotide-binding site–leucine-rich repeat class genes are required to confer Pikm-specific rice blast resistance...... 2267—2276
CHIANG, CHARLESTON W. K., ADNAN DERTI, DANIEL SCHWARTZ, MICHAEL F. CHOU, JOEL N. HIRSCHHORN AND C.-TING WU, Ultraconserved elements: Analyses of dosage sensitivity, motifs and boundaries 2277—2293 NOTE Genome integrity and transmission
MERCIER, RAPHAEL, SYLVIE JOLIVET, JULIEN VIGNARD, STÉPHANIE DURAND, JAN DROUAUD, GEORGES PELLETIER AND FABIEN NOGUÉ, Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants ...... 2295—2297 REVIEWER INDEX ...... 2299—2307 AUTHOR INDEX ...... 2309—2314 KEYWORD INDEX...... 2315—2321