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Recommendations of the ESSR Arthritis Subcommittee for the Use 396 Recommendations of the ESSR Arthritis Subcommittee for the Use of Magnetic Resonance Imaging in Musculoskeletal Rheumatic Diseases Iwona Sudoł-Szopińska, MD, PhD1 Anne Grethe Jurik, MD, DMSc2 Iris Eshed, MD3 Jans Lennart, MD4 Andrew Grainger, MRCP, FRCR5 Mikkel Østergaard, MD, PhD, DMSc6 Andrea Klauser, MD7 Anne Cotten, MD, PhD8 Marius C. Wick, MD9 Mario Maas, MD, PhD10 Falk Miese, MD11 Niels Egund, MD12 Nathalie Boutry, MD13 Mitja Rupreht, MD, PhD14 Monique Reijnierse, MD15 Edwin H. G. Oei, MD, PhD16 Reinhard Meier, MD17 Phil O’Connor, MD18 Antoine Feydy, MD, PhD19 Vasco Mascarenhas, MD20 Athena Plagou, MD21 Paolo Simoni, MD22 Hannes Platzgummer, MD23 Winston J. Rennie, MBBS24 Adam Mester, MD25 James Teh, MD26 Philip Robinson, MB ChB, MRCP, FRCR27 Giuseppe Guglielmi, MD28 Gunnar Åström, MD29 Claudia Schueller-Weiderkamm, MD30 1Department of Radiology, National Institute of Geriatrics, 16Department of Radiology, ErasmusMCRotterdam,Rotterdam,The Rheumatology and Rehabilitation, Warsaw, Poland, and Imaging Netherlands Diagnostic Department, Warsaw Medical University, Poland 17Department of Diagnostic and Interventional Radiology, University 2Division of Radiology, Aarhus University Hospital, Aarhus, Denmark Hospital Ulm, Ulm, Germany 3Department of Diagnostic Imaging, The Sheba Medical Center, Tel 18NIHR Leeds Musculoskeletal Biomedical Imaging Unit, Leeds Aviv University, Tel Aviv, Israel Teaching Hospitals, Leeds, United Kingdom 4Department of Radiology, Ghent University Hospital, Ghent, Belgium 19Department of Radiology B, Cochin Hospital, Paris University of 5Department of MSK Radiology, Leeds Teaching Hospitals, Chapel Descartes, Paris Cedex, France Allerton Orthopaedic Centre, Leeds, United Kingdom 20Department of Diagnostic Imaging, Hospital da Luz, Luz-Saude, 6Copenhagen Center for Arthritis Research, Center for Rheumatology Lisbon, Portugal and Spine Diseases, Rigshospitalet, Glostrup and University of 21Ultrasound Unit, Private Radiological Institution, Athens, Greece Copenhagen, Glostrup, Denmark 22Department of Radiology, University of Bruxelles, Reine 7Department of Radiology, Medical University Innsbruck, Section Fabiola Children’sUniversityHospitalofBruxelles,Brussels, Rheumatology and Sports Imaging, Innsbruck, Austria Belgium 8Department of Musculoskeletal Radiology, University Hospital of Lille, 23Department of Biomedical Imaging und Image-guided Therapy, Lille, France Medical University of Vienna, Vienna, Austria 9Department of Radiology, Karolinska University Hospital, Stockholm, 24Department of Radiology, Hospitals of Leicester, Leicester Royal Sweden Infirmary, Leicester, United Kingdom 10Division of Musculoskeletal Radiology, Department of Radiology, 25Department of Radiology, National Institute of Rheumatology and University of Amsterdam, Academic Medical Center, Amsterdam, Physiotherapy, Budapest, Hungary The Netherlands 26Department of Radiology, Oxford University Hospitals NHS Trust, 11Department of Diagnostic and Interventional Radiology, University Nuffield Orthopaedic Centre, Oxford, United Kingdom Düsseldorf and Practice for Radiology, Nuklear Medicine and 27Department of MSK Radiology, Leeds Teaching Hospitals, Chapel Radiotherapy, Bottop, German Allerton Orthopaedic Centre, Leeds, United Kingdom 12Department of Radiology, Aarhus University Hospital Aarhus C, 28Department of Radiology, ScientificInstituteHospital“Casa Sollievo Aarhus, Denmark della Sofferenza,” San Giovanni Rotondo, Italy 13Service de Radiopédiatrie, Hôpital Jeanne de Flandre, CHRU de Lille, 29Department of Radiology, Akademiska Sjukhuset, University Lille, France Hospital, Uppsala, Sweden Downloaded by: the European Society of Musculoskeletal Radiology. Copyrighted material. 14Department of Radiology, UMC Maribor, Maribor, Slovenia 30Division of Neuroradiology and Musculoskeletal Radiology, 15Department of Radiology, Leiden University Medical Center, Leiden, Department of Biomedical Imaging and Image-guided Therapy, The Netherlands University of Vienna, Vienna, Austria Semin Musculoskelet Radiol 2015;19:396–411. Address for correspondence Iwona Sudoł-Szopińska, MD, PhD, Department of Radiology, Institute of Rheumatology, Warsaw, Poland, and Imaging Diagnostic Department, Warsaw Medical University, Poland (e-mail: [email protected]). Issue Theme Update on Advances in Copyright © 2015 by Thieme Medical DOI http://dx.doi.org/ Musculoskeletal Magnetic Resonance Publishers, Inc., 333 Seventh Avenue, 10.1055/s-0035-1564696. Imaging; Guest Editor, Patrick Omoumi, New York, NY 10001, USA. ISSN 1089-7860. MD, MSc, PhD Tel: +1(212) 584-4662. MRI in Musculoskeletal Rheumatic Diseases Sudoł-Szopińska et al. 397 Abstract This article presents the recommendations of the European Society of Musculoskeletal Radiology Arthritis Subcommittee regarding the standards of the use of MRI in the diagnosis of musculoskeletal rheumatic diseases. The recommendations discuss (1) the Keywords role of MRI in current classification criteria of musculoskeletal rheumatic diseases ► arthritis (including early diagnosis of inflammation, disease follow-up, and identification of ► sacroiliitis disease complications); (2) the impact of MRI on the diagnosis of axial and peripheral ► spondyloarthritis spondyloarthritis, rheumatoid arthritis, and juvenile spondyloarthritis; (3) MRI protocols ► magnetic resonance for the axial and peripheral joints; (4) MRI interpretation and reporting for axial and imaging peripheral joints; and finally, (5) methods for assessing MR images including quantita- ► diagnosis tive, semiquantitative, and dynamic contrast-enhanced MRI studies. This article presents the recommendations of the European • Inflammatory and postinflammatory lesions of the verte- Society of Musculoskeletal Radiology (ESSR) Arthritis Sub- bral joints (i.e., assessment of the inflammatory activity, committee regarding the standards of the use of MRI in aseptic spondylodiscitis, atlantoaxial/atlanto-occipital radiology and rheumatology to standardize the diagnostic structural lesions work-up of patients with suspected or diagnosed rheumatic • Tenosynovitis and enthesitis diseases of the musculoskeletal system. The article was prepared on the basis of clinical expertise, It also confirms the clinical diagnosis based on imaging current literature, as well as the guidelines of the ESSR, the characteristics and/or location of lesions, and it provides Assessment of SpondyloArthritis International Society qualitative, semiquantitative, and quantitative measure- (ASAS), and the European League Against Rheumatism ments of active inflammation and chronic joint damage. (EULAR).1–8 Disadvantages of MRI include long examination times, These recommendations discuss the following topics: limited availability, limited field of view (normally a single joint/group of joints, like a hand, is examined), relatively high 1. The role of MRI in current classification criteria of muscu- cost, need for contrast medium to increase specificity, and loskeletal rheumatic diseases contraindications in certain patients. 2. The impact of MRI on the diagnosis of musculoskeletal rheumatic diseases 3. MRI protocols Impact of MRI on the Diagnosis of 4. MRI interpretation and reporting Musculoskeletal Rheumatic Diseases 5. Methods for assessing MR images Axial Spondyloarthritis The Role of MRI in Current Classification MRI plays an important role in the diagnosis of axial spondy- Criteria of Rheumatic Diseases loarthritis (SpA) by detecting sacroiliitis (ASAS imaging arm) more sensitively and also with a better reproducibility com- MRI is currently considered the best noninvasive observer- pared with conventional radiography8 (►Table 1). Spinal independent imaging modality to evaluate the inflammation inflammatory lesions suggestive of axial SpA are rarely found of joints, tendons, entheses, and bone marrow. in the absence of sacroiliitis on MRI (or radiography).9 These are the main indications for MRI in patients with In patients with clinically suspected axial SpA, MRI is most Downloaded by: the European Society of Musculoskeletal Radiology. Copyrighted material. musculoskeletal rheumatic diseases: commonly performed for the following reasons5: • Early diagnosis of inflammation • To visualize active inflammatory lesions in the sacroiliac • Confirmation of the presence of clinically active changes joints and the spine, particularly in young patients or and postinflammatory structural lesions patients with a short history of disease, or where clinical • Disease follow-up including monitoring of therapy findings and conventional radiography fail to confirm the response disease definitively • Identification of disease complications • To show structural lesions early in the disease course • In particular, MRI facilitates the following assessments: To monitor disease activity and assess response to therapy • Peripheral joints for active inflammation in the form of The role of MRI needs to be determined to: effusion, synovitis, bone marrow edema (BME), as well as the subsequent structural lesions, such as articular surface • Monitor structural changes of the sacroiliac joints and the damage and cortical bone erosions spine • Active inflammatory lesions and structural changes in the • Predict development of new syndesmophytes from so- sacroiliac joints called vertebral corner inflammatory lesions Seminars in Musculoskeletal Radiology Vol. 19 No. 4/2015 398 MRI in Musculoskeletal Rheumatic Diseases Sudoł-Szopińska et al. Table 1 ASAS 2010 criteria for classification of axial spondyloarthritis2,3,8 Back pain 3moandageatonset<
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