Nardil (Phenelzine) Basics Powered by Stabilizes Your Mood

Total Page:16

File Type:pdf, Size:1020Kb

Nardil (Phenelzine) Basics Powered by Stabilizes Your Mood Powered by Nardil (phenelzine) basics Stabilizes your mood. Nardil (phenelzine) is not a first choice for treating depression, but it can be good if other medicines haven't worked. It can interact with a lot of medicines, and you have to avoid certain foods and alcohol. What to expect when starting Here's when people typically experience benefits as well as some possible side effects. Your experience may be different. Hours Days Weeks Months Long term Nardil (phenelzine) Drug effectiveness Possible side effects† Hours Days Weeks Months Long term Higher risk of suicide Dizziness Changes in sleep Weight gain Constipation Lower sex drive † Data on frequency of side effects is not available. Tips from pharmacists If you're switching from Nardil (phenelzine) to another antidepressant, you have to wait at least 2 weeks after stopping Nardil (phenelzine) to safely start the new one. Avoid smoked meats, cheese, soy sauce, and other fermented foods because Nardil (phenelzine) can raise your blood pressure. Nardil (phenelzine) can cause weight gain. You might not notice any changes in your mood until you've taken Nardil (phenelzine) for at least 4 weeks. Don't stop taking Nardil (phenelzine) suddenly without talking to your doctor first. Avoid alcohol and limit the amount of caffeine you take if you take Nardil (phenelzine). Risks and warnings The FDA has identified these as possible serious or life-threatening risks with this medication. Contact your doctor if you experience any of these. Higher risk of suicide Possible bipolar disorder High blood pressure Taking Nardil (phenelzine) can make you Sometimes depression can be the first sign Eating certain foods or drinking beer or wine more likely to harm yourself or commit of a bipolar disorder, and taking medicines while taking Nardil (phenelzine) can cause suicide, especially if you are younger and like Nardil (phenelzine) might start a bipolar your blood pressure to become dangerously during the first few weeks of taking it. If you episode. Talk to your doctor right away if you high. Talk to your doctor or go to the or your child feel like they want to hurt or your loved ones notice unusual changes emergency room right away if you get a very themselves while taking Nardil (phenelzine), in your behavior. bad headache, changes in your heart rate, call the doctor right away. neck stiffness or soreness, or nausea and vomiting. This information relates to phenelzine prescribed for Depression. This should not be taken as medical advice or guidance on your prescription, and is not a substitute for a health care provider's judgment. Any decision about the treatment or the reliability of information is the sole responsibility of your health care provider. For more information and to see what other people experienced, check out /drug/phenelzine..
Recommended publications
  • Ayahuasca: Spiritual Pharmacology & Drug Interactions
    Ayahuasca: Spiritual Pharmacology & Drug Interactions BENJAMIN MALCOLM, PHARMD, MPH [email protected] MARCH 28 TH 2017 AWARE PROJECT Can Science be Spiritual? “Science is not only compatible with spirituality; it is a profound source of spirituality. When we recognize our place in an immensity of light years and in the passage of ages, when we grasp the intricacy, beauty and subtlety of life, then that soaring feeling, that sense of elation and humility combined, is surely spiritual. The notion that science and spirituality are somehow mutually exclusive does a disservice to both.” – Carl Sagan Disclosures & Disclaimers No conflicts of interest to disclose – I don’t get paid by pharma and have no potential to profit directly from ayahuasca This presentation is for information purposes only, none of the information presented should be used in replacement of medical advice or be considered medical advice This presentation is not an endorsement of illicit activity Presentation Outline & Objectives Describe what is known regarding ayahuasca’s pharmacology Outline adverse food and drug combinations with ayahuasca as well as strategies for risk management Provide an overview of spiritual pharmacology and current clinical data supporting potential of ayahuasca for treatment of mental illness Pharmacology Terms Drug ◦ Term used synonymously with substance or medicine in this presentation and in pharmacology ◦ No offense intended if I call your medicine or madre a drug! Bioavailability ◦ The amount of a drug that enters the body and is able to have an active effect ◦ Route specific: bioavailability is different between oral, intranasal, inhalation (smoked), and injected routes of administration (IV, IM, SC) Half-life (T ½) ◦ The amount of time it takes the body to metabolize/eliminate 50% of a drug ◦ E.g.
    [Show full text]
  • Long-Lasting Analgesic Effect of the Psychedelic Drug Changa: a Case Report
    CASE REPORT Journal of Psychedelic Studies 3(1), pp. 7–13 (2019) DOI: 10.1556/2054.2019.001 First published online February 12, 2019 Long-lasting analgesic effect of the psychedelic drug changa: A case report GENÍS ONA1* and SEBASTIÁN TRONCOSO2 1Department of Anthropology, Philosophy and Social Work, Universitat Rovira i Virgili, Tarragona, Spain 2Independent Researcher (Received: August 23, 2018; accepted: January 8, 2019) Background and aims: Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa,a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in β-carbolines. Methods: We describe the case and offer a brief review of supportive findings. Results: A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved. Conclusion: These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work. Keywords: analgesic, pain, psychedelic, psychoactive, DMT, β-carboline alkaloids INTRODUCTION effects of ayahuasca usually last between 3 and 5 hr (McKenna & Riba, 2015), but the effects of smoked changa – The treatment of pain is one of the most significant chal- last about 15 30 min (Ott, 1994). lenges in the history of medicine. At present, there are still many challenges that hamper pain’s appropriate treatment, as recently stated by American Pain Society (Gereau et al., CASE DESCRIPTION 2014).
    [Show full text]
  • Designing Inhibitors Via Molecular Modelling Methods for Monoamine Oxidase Isozymes a and B Filiz Varnali Kadir Has Universit
    DESIGNING INHIBITORS VIA MOLECULAR MODELLING METHODS FOR MONOAMINE OXIDASE ISOZYMES A AND B FİLİZ VARNALI KADİR HAS UNIVERSITY 2012 DESIGNING INHIBITORS VIA MOLECULAR MODELLING METHODS FOR MONOAMINE OXIDASE ISOZYMES A AND B FİLİZ VARNALI M.S. in Computational Biology and Bioinformatics, Kadir Has University, 2012 Submitted to the Graduate School of Science and Engineering in partial fulfilment of the requirements for the degree of Master of Science in Computational Biology and Bioinformatics KADİR HAS UNIVERSITY 2012 DESIGNING INHIBITORS VIA MOLECULAR MODELING METHODS FOR MONOAMINE OXIDASE ISOZYMES A AND B Abstract In drug development studies, a large number of new drug candidates (leads) have to be synthesized and optimized by changing several moieties of the leads in order to increase efficacies and decrease toxicities. Each synthesis of these new drug candidates include multi-steps procedures. Overall, discovering a new drug is a very time-consuming and very costly works. The development of molecular modelling programs and their applications in pharmaceutical research have been formalized as a field of study known computer assisted drug design (CADD) or computer assisted molecular design (CAMD). In this study, using the above techniques, Monoamine Oxidase isozymes, which play an essential role in the oxidative deamination of the biogenic amines, were studied. Compounds that inhibit these isozymes were shown to have therapeutic value in a variety of conditions including several psychiatric and neurological as well as neurodegenerative diseases. First, a series of new pyrazoline derivatives were screened using molecular modelling and docking methods and promising lead compounds were selected, and proposed for synthesis as novel selective MAO-A or –B inhibitors.
    [Show full text]
  • Phenelzine in the Treatment of Depressive Illness
    Hull & East Riding Prescribing Committee Prescribing Framework for Phenelzine in the treatment of depressive illness Patients Name:…………………………………………………..… NHS Number: ……………… Patients Address:……………………………………………...……(Use addressograph sticker) GP’s Name:……………………………………………………….…….. Communication We agree to treat this patient within this Prescribing Framework Specialist Prescriber’s Name………………………………………… Prof Reg. No. ………… Specialist Prescriber’s Signature…………………………………… Date:……………………. Where prescriber is not a consultant: Consultant’s Name: ………………………………………………… GMC No ……………….. Consultant’s Signature ………………………….... ………………. Date:……………………. GP’s Signature:………………………………………………………… Date:…………………….. GP’s Name (if different from listed above)………………………….. The front page of this form should be completed by the specialist and the form sent to the patient’s general practitioner. The patient’s GP should sign and send back to specialist, to confirm agreement to enter into shared care arrangement. If the General Practitioner is unwilling to accept prescribing responsibility for the above patient the specialist should be informed within two weeks of receipt of this framework and specialist’s letter. Full copy of framework can also be found at : http://www.hey.nhs.uk/amber.htm Prescribing framework for Phenelzine Date approved by HERPC : March 2021 Review date: April 2024 Page 1 of 7 APPROVAL PROCESS Written by: Jackie Stark, Principal Pharmacist HFT Wendy Tucker, Pharmacist Reviewed by Karen Thompson , Specialist Pharmacist May 2017 Reviewed by Wendy Storey Feb
    [Show full text]
  • Insights Into the Mechanisms of Action Ofthe MAO Inhibitors Phenelzine and Tranylcypromine
    Insights into the Mechanisms of Action of the MAO Inhibitors Phenelzine and Tranylcypromine: A Review Glen B. Baker, Ph.D., Ronald T. Coutts, Ph.D., D.Sc., Kevin F. McKenna, M.D., and Rhonda L. Sherry-McKenna, B.Sc. Neurochemical Research Unit, Department of Psychiatry and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta Submitted: July 10, 1992 Accepted: October 7, 1992 Although the non-selective monoamine oxidase inhibitors phenelzine and tranylcypromine have been used for many years, much still remains to be understood about their mechanisms of action. Other factors, in addition to the inhibition of monoamine oxidase and the subsequent elevation of brain levels of the catecholamines and 5-hydroxytryptamine, may contribute to the overall pharma- cological profiles ofthese drugs. This review also considers the effects on brain levels of amino acids and trace amines, uptake and release of neurotransmitter amines at nerve terminals, receptors for amino acids and amines, and enzymes other than monoamine oxidase, including enzymes involved in metabolism of other drugs. The possible contributions of metabolism and stereochemistry to the actions of these monoamine oxidase inhibitors are discussed. Key Words: amino acids, monoamine oxidase, neurotransmitter amines, phenelzine, tranylcypromine, uptake Despite the fact that the non-selective monoamine oxidase nerve endings (Baker et al 1977; Raiteri et al 1977) and/or (MAO) inhibitors phenelzine (PLZ) and tranylcypromine may act as neuromodulators through direct actions on recep- (TCP) (see Fig. 1) have been used clinically for many years, tors for the catecholamines and/or 5-HT (Jones 1983; much remains to be learned about theirmechanisms ofaction.
    [Show full text]
  • Ayahuasca Characterization, Metabolism in Humans, And
    Louisiana State University LSU Digital Commons LSU Doctoral Dissertations Graduate School 2012 Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N- dimethyltryptamines Ethan Hamilton McIlhenny Louisiana State University and Agricultural and Mechanical College, [email protected] Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_dissertations Part of the Medicine and Health Sciences Commons Recommended Citation McIlhenny, Ethan Hamilton, "Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N- dimethyltryptamines" (2012). LSU Doctoral Dissertations. 2049. https://digitalcommons.lsu.edu/gradschool_dissertations/2049 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Doctoral Dissertations by an authorized graduate school editor of LSU Digital Commons. For more information, please [email protected]. AYAHUASCA CHARACTERIZATION, METABOLISM IN HUMANS, AND RELEVANCE TO ENDOGENOUS N,N-DIMETHYLTRYPTAMINES A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and School of Veterinary Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Interdepartmental Program in Veterinary Medical Sciences through the Department of Comparative Biomedical Sciences by Ethan Hamilton McIlhenny B.A., Skidmore College, 2006 M.S., Tulane University, 2008 August 2012 Acknowledgments Infinite thanks, appreciation, and gratitude to my mother Bonnie, father Chaffe, brother Matthew, grandmothers Virginia and Beverly, and to all my extended family, friends, and loved ones. Without your support and the visionary guidance of my friend and advisor Dr. Steven Barker, none of this work would have been possible. Special thanks to Dr.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2015/0011643 A1 Dilisa Et Al
    US 2015 0011643A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0011643 A1 DiLisa et al. (43) Pub. Date: Jan. 8, 2015 (54) TREATMENT OF HEART FAILURE AND (60) Provisional application No. 61/038,230, filed on Mar. ASSOCATED CONDITIONS BY 20, 2008, provisional application No. 61/155,704, ADMINISTRATION OF MONOAMINE filed on Feb. 26, 2009. OXIDASE INHIBITORS (71) Applicants:Nazareno Paolocci, Baltimore, MD Publication Classification (US); Univeristy of Padua, Padova (IT) (51) Int. Cl. (72) Inventors: Fabio DiLisa, Padova (IT): Ning Feng, A63L/38 (2006.01) Baltimore, MD (US); Nina Kaludercic, (52) U.S. Cl. Baltimore, MD (US); Nazareno CPC ..... ... A61 K31/138 (2013.01) Paolocci, Baltimore, MD (US) USPC .......................................................... S14/651 (21) Appl. No.: 14/332,234 (22) Filed: Jul. 15, 2014 (57) ABSTRACT Related U.S. Application Data Administration of monoamine oxidase inhibitors is useful in (63) Continuation of application No. 12/407,739, filed on the prevention and treatment of heart failure and incipient Mar. 19, 2009, now abandoned. heart failure. Patent Application Publication Jan. 8, 2015 Sheet 1 of 2 US 201S/0011643 A1 Figure 1 Sial 8. Sws-L) Cleaved Š Caspase-3 ) Figure . Prevention of caspase-3 productief) fron cardiomyocytes Lapoi) reatment with clorgyi Be. Patent Application Publication Jan. 8, 2015 Sheet 2 of 2 US 201S/0011643 A1 Figure 2 8:38:8 ::::::::8: US 2015/0011643 A1 Jan. 8, 2015 TREATMENT OF HEART FAILURE AND in the art is a variety of MAO inhibitors and their pharmaceu ASSOCATED CONDITIONS BY tically acceptable compositions for administration, in accor ADMINISTRATION OF MONOAMINE dance with the present invention, to mammals including, but OXIDASE INHIBITORS not limited to, humans.
    [Show full text]
  • Attendee Guidelines
    (Temple of Eternal Sound) Attendee Guidelines 1. Introduction 2. Practical Guidelines -Preparation -Contraindications -Food -Clothing -Cleansing -During the Session -Suggested Best Practices -Temple Practices & Ritual Norms -Single Sacrament Sanctuary 3. Code of Ethics 4. Dietary Guidelines 5. Medical Information 6. Attendee Waiver Céu do Som Welcome, Thank you for your interest in our Forest Family Circles, Realisation Retreats and Wisdom Works at the Temple of Céu do Som & Abuelatree Sanctuary. You are endeavouring to participate in what, for us, is one of the most profound and meaningful doorways into the mysteries of the Sacred & Profound. The following pages are practical suggestions outlining our expectations, guidelines and safety measures to ensure harmony for you, for our work and for our community. We seek to uphold a high standard in regards to the safe space of transformation and realisation that may create a positive impact through healing and integration of our participants. The guidelines in this booklet all serve a direct purpose. We ask that each one be approached with due respect. It is not necessary to subscribe to our points of view in order to receive the sacrament. We do not discriminate and find that ultimately it is up to the individual to discover what is true for them. Así Céu do Som PRACTICAL GUIDELINES Preparation for the spiritual study Contraindications (refer to Medical Information section for more details) 1. If you are uncertain about any contraindications or factors please ask. 2. If you have any personal concerns a meeting can be arranged prior in order to discuss. 3. If you are taking any prescription medication, namely antidepressants, antipsychotics or SSRI's please speak to us (Refer to Medical Information section).
    [Show full text]
  • The Effect of Antidepressive Drugs and Some Related Compounds on the Levels of Adenine Nucleotides, Inorganic Phosphate and Phosphocreatine in the Rat Brain by J
    Brit. J. Pharmacol. (1963), 20, 462-470. THE EFFECT OF ANTIDEPRESSIVE DRUGS AND SOME RELATED COMPOUNDS ON THE LEVELS OF ADENINE NUCLEOTIDES, INORGANIC PHOSPHATE AND PHOSPHOCREATINE IN THE RAT BRAIN BY J. J. LEWIS AND G. R. VAN PETTEN From the Experimental Pharmacology Division, Institute of Physiology, University of Glasgow (Received January 11, 1963) The effects upon levels of adenine nucleotides, phosphocreatine and inorganic phosphate of iproniazid, isoniazid, phenelzine, pheniprazine, tranylcypromine, harmine, imipramine, amitriptyline, orphenadrine, diphenhydramine and cocaine have been studied. With the exception of harmine and diphenhydramine, each of these compounds increased the brain level of adenosine triphosphate and, with the exception of imipramine and cocaine, the level of adenosine diphosphate decreased. Harmine had no effect on levels of adenine nucleotides and, in the case of diphenhydramine, the level of adenosine diphosphate increased and the level of adenosine triphosphate tended to decrease. There appears to be a relationship between the ability of the drugs to cause behavioural signs of central nervous stimulation and to produce an increase in the adenosine triphosphate/diphosphate ratio. This effect may be a factor in the action of antidepressive drugs. Many attempts have been made to explain the mechanism of action of anti- depressive drugs on the basis of their ability to inhibit monoamine oxidase, and thereby to increase the effective concentrations in the brain of its substrates, nor- adrenaline and 5-hydroxytryptamine, which have been postulated to act there as transmitters. Major difficulties arise, however, when an attempt is made to correlate the increase in the brain level of a particular amine produced by a drug with its antidepressive activity.
    [Show full text]
  • NARDIL® (Phenelzine Sulfate Tablets, USP)
    NARDIL® (Phenelzine Sulfate Tablets, USP) Suicidality in Children and Adolescents Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of NARDIL or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. NARDIL is not approved for use in pediatric patients. (See Warnings and Precautions: Pediatric Use) Pooled analyses of short-term (4 to 16 weeks) placebo-controlled trials of 9 antidepressant drugs (SSRIs and others) in children and adolescents with major depressive disorde r (MDD), obsessive compulsive disorder (OCD), or other psychiatric disorders (a total of 24 trials involving over 4400 patients) have revealed a greater risk of adverse events representing suicidal thinking or behavior (suicidality) during the first few months of treatment in those receiving antidepressants. The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. No suicides occurred in these trials. DESCRIPTION NARDIL® (phenelzine sulfate) is a potent inhibitor of monoamine oxidase (MAO). Phenelzine sulfate is a hydrazine derivative. It has a molecular weight of 234.27 and is chemically described as C8 H12 N2 · H2SO4. Its chemical structure is shown below: Each NARDIL film-coated tablet for oral administration contains phenelzine sulfate equivalent to 15 mg of phenelzine base and the following inactive ingredients: mannitol, USP; croscarmellose sodium, NF; povidone, USP; edetate disodium, USP; magnesium stearate, NF; isopropyl alcohol, USP; purified water, USP; opadry orange Y30-13242A; simethicone emulsion, USP.
    [Show full text]
  • Ayahuasca Characterization, Metabolism in Humans, and Relevance to Endogenous N,N-Dimethyltryptamines
    ______________________________________________________________________________________________www.neip.info AYAHUASCA CHARACTERIZATION, METABOLISM IN HUMANS, AND RELEVANCE TO ENDOGENOUS N,N-DIMETHYLTRYPTAMINES A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and School of Veterinary Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Interdepartmental Program in Veterinary Medical Sciences through the Department of Comparative Biomedical Sciences by Ethan Hamilton McIlhenny B.A., Skidmore College, 2006 M.S., Tulane University, 2008 August 2012 ______________________________________________________________________________________________www.neip.info Acknowledgments Infinite thanks, appreciation, and gratitude to my mother Bonnie, father Chaffe, brother Matthew, grandmothers Virginia and Beverly, and to all my extended family, friends, and loved ones. Without your support and the visionary guidance of my friend and advisor Dr. Steven Barker, none of this work would have been possible. Special thanks to Dr. Rick Strassman MD and the Cottonwood Research Foundation for helping me find and navigate this path. We acknowledge and are grateful for the collaborative research efforts and dedication of Dr. Jordi Riba and his lab which obtained the human urine and blood samples necessary for the included studies. We wish to dedicate this work to the memory of our friend and colleague, Dr. Manel J. Barbanoj. We acknowledge Dr. Leanna Standish for her diligent work in bringing ayahuasca towards clinical trials and collaborative efforts in supplying our lab with ayahuasca samples. We thank Dr. Dave E. Nichols, Dr. Laurent Micouin and Dr. Simon D. Brandt for generously providing analytical compounds. We thank Connie David, Izabela Lomnicka, Pam Waller and Marian Waguespack for technical support in lab.
    [Show full text]
  • Phenelzine Switching Advice 11 May 2020
    Mental Health Special Interest Group Guidance for switching from phenelzine to another antidepressant The supplier of phenelzine sulphate tablets has notified PHARMAC that they can no longer supply this medication in New Zealand. This is reportedly a global issue so the supplier can no longer guarantee supply of any brand of phenelzine. Supplies of phenelzine tablets are likely to run out by mid-late May 2020. People taking phenelzine should be reviewed and, if appropriate, transitioned to another antidepressant as soon as possible. Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class. The only remaining non-selective irreversible MAOI available in New Zealand is tranylcypromine. Tranylcypromine is a non-hydrazine MAOI and differs significantly from phenelzine in some aspects, as outlined below. Tranylcypromine may be an appropriate alternative antidepressant for some patients ; however, it is important to consider an individual’s physical health and psychiatric history, and whether an MAOI is still appropriate. General practitioners should consult with a psychiatrist regarding treatment options and transition. Reducing and stopping phenelzine The dose of phenelzine should ideally be tapered down over a minimum of four weeks, starting immediately in light of very limited supplies. We acknowledge that a faster taper may be required in some cases due to rapidly declining stock. Irreversible MAOIs are associated with a high risk of discontinuation symptoms, e.g. nightmares, headache, irritability, feeling cold, disorientation, hypomania, nausea, sweating, palpitations, myoclonic jerks and, rarely, catatonia or psychosis. Significant discontinuation symptoms should be closely monitored and managed in consultation with a psychiatrist. It is important to maintain MAOI dietary and co-prescribed medication precautions for at least 14 days after stopping phenelzine.
    [Show full text]