JOURNAL OF VIROLOGY VOLUME 59 * SEPTEMBER 1986 * NUMBER 3 Arnold J. Levine, Editor in Chief Michael B. A. Oldstone, Editor (1988) (1989) Scripps Clinic & Research Foundation Princeton University La Jolla, Calif. Princeton, N.J. Thomas E. Shenk, Editor (1989) David T. Denhardt, Editor (1987) Princeton University University of Western Ontario Princeton, N.J. London, Ontario, Canada Anna Marie Skalka, Editor (1989) Bernard N. Fields, Editor (1988) Hoffmann-La Roche Inc. Harvard Medical School Nutley, N.J. Boston, Mass. Robert A. Weisberg, Editor (1988) Robert M. Krug, Editor (1987) National Institute of Child Health Sloan-Kettering Institute and Human Development New York, N.Y. Bethesda, Md. EDITORIAL BOARD James Alwine (1988) Hidesaburo Hanafusa (1986) Lois K. Miller (1988) Priscilla A. Schaffer (1987) David Baltimore (1987) William S. Hayward (1987) Peter Model (1986) Sondra Schlesinger (1986) Tamar Ben-Porat (1987) Roger Hendrix (1987) Bernard Moss (1986) Manfred Schubert (1988) Kenneth I. Berns (1988) Martin Hirsch (1986) Fred Murphy (1986) June R. Scott (1986) Michael Botchan (1986) John J. Holland (1987) Opendra Narayan (1988) Bart Sefton (1988) Thomas J. Braciale (1988) Ian H. Holmes (1986) Joseph R. Nevins (1988) Charles J. Sherr (1987) Joan Brugge (1988) Robert W. Honess (1986) Nancy G. Nossal (1987) Silverstein Barrie J. Carter (1987) Nancy Hopkins (1986) Abner Notkins (1986) Saul J. (1988) John M. Coffin (1986) Peter M. Howley (1987) J. Thomas Parsons (1986) Patricia G. Spear (1987) Geoffrey M. Cooper (1987) Alice S. Huang (1987) Ulf G. Pettersson (1986) Nat Sternberg (1986) Donald Court (1987) Steve Hughes (1988) Lennart Philipson (1987) Bruce Stillman (1988) Richard Courtney (1986) Tony Hunter (1986) Lewis I. Pizer (1987) Mark F. Stinski (1986) Clyde S. Crumpacker II Jack D. Keene (1988) Craig R. Pringle (1986) James Strauss (1987) (1988) Thomas J. Kelly, Jr. (1988) Carol Prives (1986) F. William Studier (1987) Thomas Curran (1988) George Khoury (1987) Robert Purcell (1986) Lawrence S. Sturman (1988) Walter Doerfler (1986) Elliott Kieff (1987) R. Frank Ramig (1988) John M. Taylor (1987) Peter Doherty (1986) David Knipe (1988) Fred Rapp (1987) Howard M. Temin (1988) Elvera Ehrenfeld (1986) Daniel Kolakofsky (1986) Dan S. Ray (1986) George F. Vande Woude (1986) Robert N. Eisenman (1988) Michael Lai (1988) Gordon M. Ringold (1987) Inder Verma (1986) Suzanne U. Emerson (1986) Robert Lamb (1988) Harriet Robinson (1988) Edward K. Wagner (1986) Ellen Fanning (1988) Robert A. Lazzarini (1987) William S. Robinson (1986) Raymond M. Welsh, Jr. (1988) Emanuel Faust (1987) Myron Levine (1988) Bernard Roizman (1988) Gail Wertz (1988) S. Jane Flint (1987) Maxine Linial (1988) John K. Rose (1988) Reed B. Wickner (1988) Donald Ganem (1988) Douglas R. Lowy (1986) Naomi Rosenberg (1986) Eckard Wimmer (1988) Costa Georgopolous (1986) Robert Martin (1987) Roland R. Rueckert (1988) Owen Witte (1986) Walter Gerhard (1986) Warren Masker (1987) Norman P. Salzman (1987) Charles Hamish Young (1986) Stephen P. Goff (1988) Thomas Merigan (1986) Joseph Sambrook (1988) Julius S. Youngner (1986) Larry M. Gold (1988) George Miller (1987) Charles E. Samuel (1986) Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director of Publications Linda M. Illig, Managing Editor, Journals Judith Nedrow, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $285 per year; single copies are $21. The member subscription price is $41 (foreign, $54 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). 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Alatossava, Tapani, 551 Enquist, Lynn W., 635 McFarland, Vivian, 628 Shaul, Yosef, 731 Alegre, John N., 669 McMaster, Gary K., 564 Sladek, Todd L., 584 Allaway, Graham P., 768 Faras, Anthony J., 669 Merz, Patricia A., 676 Smith, Rosalind, 535 Arnheiter, Heinz, 751 Fraser, Nigel W., 764 Mora, Peter T., 628 Sodroski, Joseph, 743 Asselin, Claude, 655 Frenkel, Niza, 605 Moss, Jill, 728 Soong, Meei-Meei, 556 Muggeridge, Martin I., 764 Soussi, Thierry, 740 Babinet, Charles, 761 Garcia, Pablo D., 731 Murphy, Cheryl Isaac, 692 Spector, Deborah H., 591 Baksi, Krishna, 628 Gibson, Wade, 703, 714 Spriggs, Melanie K., 646 Bastin, Marcel, 655 Goff, Stephen P., 743 O'Brien, Stephen J., 545 Steele, Paul E., 545 Benko, Donna Mia, 703 Gresser, Ion, 728 Ostrove, Jeffrey M., 660 Straus, Steven E., 660 Bernards, R., 684 Bikel, Ilan, 692 Haseltine, William A., 743 Parrott, Catherine L., 628 Bos, J. L., 684 Hay, John, 660 Parsons, J. Thomas, 755 Tamashiro, Joyce C., 591 Boyce-Jacino, Mike, 669 Hirt, Bernhard, 564 Parsons, Sarah J., 755 Tan, Tse-Hua, 574 Brookes, Sharon, 535 Houweling, A., 684 Peters, Gordon, 535 Tanese, Naoko, 743 Bryan, Theodore, 545 Pfau, Charles, 728 Trautwetter, Annie, 551 Bukowski, Jack F., 735 lijima, Shinji, 556 Placzek, Marysia, 535 Burness, Alfred T. H., 768 Jat, Parmjit S., 746 Rabson, Arnold B., 545 Carp, Richard I., 676 Jochemsen, A. G., 684 Ratiarson, Annick, 655 van der Eb, A. J., 684 Chalifour, Lorraine E., 619 Jongeneel, C. Victor, 564 Raymond, Victoria W., 755 van Kranen, H. J., 684 Chou, Joany, 605 Remenick, James, 660 Vass-Marengo, Judit, 655 Clark, Thomas, 728 Kascsak, Richard J., 676 Resnick, Robert, 669 Collins, Peter L., 646 Kinchington, Paul R., 660 Ritzenthaler, Paul, 551 Cremisi, Chantal, 761 Kozak, Christine, 535 Robakis, Nickolaos K., 676 Wallis, John, 574 Robbins, Alan K., 635 Wang, Lu-Hai, 556 Davis, Nancy L., 751 LeMaster, David M., 759 Roby, Clinton, 714 Wassarman, Paul M., 619 Deiss, Louis P., 605 Levine, Arnold J., 574 Rubenstein, Richard, 676 Watson, Roger J., 635 DePamphilis, Melvin L., 619 Livingston, David M., 692 Rutter, William J., 731 Welsh, Raymond M., 735 Dickson, Clive, 535 Ruyechan, William T., 660 Wertz, Gail W., 751 Diringer, Heino, 676 Maniloff, Jack, 584 Whealy, Mary E., 635 Dunwiddie, Christopher T., Martin, Malcolm A., 545 Sahli, Roland, 564 Wirak, Dana O., 619 669 Mata-Gilsinger, Mireille, 551 Schonberg, Steven, 731 Wisniewski, Henryk M., 676 Dybvig, Kevin, 584 McCarley, Deborah J., 755 Sharp, Phillip A., 746 Woodrow, David, 728 AUTHOR INDEX

VOLUME 59

Abe, Mitsuko, 103 Davis, Mark M., 434 Ibanez, Carlos E., 267 Matsubara, Kenichi, 176 Adachi, Akio, 284 Davis, Nancy L., 751 lijima, Shinji, 556 McCarley, Deborah J., 755 Alatossava, Tapani, 551 Deiss, Louis P., 605 lizuka, Hideaki, 242 McFadden, G., 249 Alegre, John N., 669 DeLange, A. M., 249 Ikuta, Kazuyoshi, 154 McFarland, Vivian, 628 Allaway, Graham P., 768 DePamphilis, Melvin L., 619 Imamura, Takayuki, 176 McMaster, Gary K., 564 Andrisani, Ourania, 420 Dickson, Clive, 535 Isfort, R. J., 411 Medina, Daniel, 518 Araki, Masatake, 176 Diringer, Heino, 676 Itin, Ahuva, 301 Merz, David C., 392 Armentrout, Marty A., 216 Donoghue, Daniel J., 292 Ito, Shin-ichi, 103 Merz, Patricia A., 676 Arnheiter, Heinz, 751 Dunwiddie, Christopher T., Iwamoto, S., 112 Milanesi, G., 500 Asselin, Claude, 655 669 Iwasaki, Yuzo, 242 Miyanohara, Atsushi, 176 Auger, Denise, 185 Dybvig, Kevin, 584 Mora, Peter T., 628 Jansen, Hans W., 341 Moran, Patricia A., 506 Babinet, Charles, 761 Eggerding, F., 112 Janssen, Robert S., 1 Mortel, Rodrigue, 369 Babiuk, Lorne A., 401 Endres, Michael J., 1 Jat, Parmjit S., 746 Moscona, Anne, 377 Baczko, Knut, 472 Engers, Howard D., 8 Jenkins, Frank J., 494 Moss, Bernard, 506 Baksi, Krishna, 628 Enquist, Lynn W., 635 Jochemsen, A. G., 684 Moss, Jill, 728 Balboni, P. G., 500 Ewalt, Larry C., 514 Jones, Nicholas, 420 Mottet, Genevieve, 132 Baluda, Marcel A., 267 Jongeneel, C. Victor, 8, 564 Muggeridge, Martin I., 764 Barbanti-Brodano, G., 500 Falck-Pederson, E., 112 Murphy, Cheryl Isaac, 692 Bartlett, Gerald L., 369 Faras, Anthony J., 669 Kanda, Tadahito, 531 Bassel-Duby, Rhonda, 90 Feinberg, Mark B., 434 Kascsak, Richard J., 676 Nakajima, Kazuhiro, 154 Bassiri, Mansour, 525 Ferguson, Blair, 420 Kato, Shiro, 154 Nakanaga, Kazue, 168 Bastin, Marcel, 655 Fields, Bernard N., 90 Katz, Richard A., 163 Narayan, Opendra, 37 Baumbach, William R., 276 Fisher, Christopher M., 31 Kaye, Kenneth M., 90 Nathanson, Neal, 1 Benko, Donna Mia, 703 Folks, Thomas, 284 Kean, Katherine M., 490 Negrini, M., 500 Ben-Porat, Tamar, 308, 318 Frank, Ronald, 341 Keath, Elizabeth J., 276 Nicolas, Jean-Claude, 510 Berk, Arnold J., 14 Fraser, Nigel W., 764 Kennedy-Stoskopf, Suzanne, Nishimune, Takahiro, 103 Bernards, R., 684 Frenkel, Niza, 605 37 Nuss, Donald L., 195 Beyreuther, Konrad, 50 Fried, Victor A., 224 Keshet, Eli, 301 Bikel, Ilan, 692 Fujiwara, Kosaku, 168 Kieff, Elliott, 453 O'Brien, Stephen J., 545 Bilello, John A., 234 Furuno, Akemi, 531 Kiessling, R., 428 Ohtomo, Nobuya, 176 Billeter, Martin, 472 Kimoto, Mitsuaki, 103 Oldstone, Michael B. A., 127, Bishop, J. Michael, 172 Gannon, Julian V., 444 Kimsey, Paul B., 8 363 Bister, Klaus, 341 Garbarg-Chenon, Antoine, 510 Kinchington, Paul R., 660 Oostra, Ben A., 82, 384 Blair, Phyllis B., 159 Garber, Theodore, 98 Knepper, Janice E., 518 Ostrove, Jeffrey M., 660 Blocker, Helmut, 341 Garcia, Pablo D., 731 Knupp, C., 59 Boeye, Albert, 479 Gaynor, Richard B., 14 Koenig, Scott, 284 Pagano, Joseph S., 522 Bos, J. L., 684 Gendelman, Howard E., 284 Konno, Hidehiko, 242 Pagnani, M., 500 Boyce-Jacino, Mike, 669 Gibson, Wade, 703, 714 Kopecka, Helena, 490 Palese, Peter, 377 Bricout, Fernand, 510 Girard, Marc, 490 Kozak, Christine, 535 Palkonyay, Laszlo, 189 Britt, William J., 185 Glorioso, J. C., 142 Kreider, John W., 369 Pan, Wayne T., 377 Bro-J0rgensen, K., 428 Goff, Stephen P., 328, 743 Krippl, Bernd, 420 Parrott, Catherine L., 628 Brookes, Sharon, 535 Goh, Wei Chun, 181 Kudo, Hiroko, 242 Parsons, J. Thomas, 755 Bryan, Theodore, 545 Goldbach, Rob, 50 Kung, H. J., 411 Parsons, Sarah J., 755 Buchmeier, M. J., 463 Gonzalez-Scarano, Francisco, Parvin, Jeffrey D., 377 Budka, Herbert, 472 1 Lampert, P. W., 463 Patschinsky, Tilo, 73, 341 Bukowski, Jack F., 735 Gresser, Ion, 728 Lane, David P., 444 Peters, Gordon, 535 Burness, Alfred T. H., 768 Lasky, Laurence A., 506 Peterson, Andrew J., 195 Butel, Janet S., 518 Hadlow, William J., 514 Leider, Jason M., 377 Petrovskis, Erik A., 216 Hampe, Annie, 224 LeMaster, David M., 759 Pfau, Charles, 728 Carp, Richard I., 676 Hannink, Mark, 292 Levine, Arnold J., 574 Pisa, P., 428 Cattaneo, Roberto, 472 Harper, Linda, 308, 318 Levine, M., 142 Pitts, Olin M., 234 Chalifour, Lorraine E., 619 Harvey, Robert, 384 Liebert, Uwe G., 472 Placzek, Marysia, 535 Chambers, Judith A., 354 Haseltine, William A., 181, Liegler, Teri J., 159 Ponticelli, Alfred, 14 Chen, Pei-Jer, 354 743 Lill, Nancy L., 369 Portner, Allen, 132 Chen, Steve S.-L., 210 Hay, John, 660 Lin, Jung-Chung, 522 Post, Leonard E., 216 Cheng, Seng H., 82 Hayashi, Ryoji, 103 Lipsick, Joseph S., 267 Privalsky, Martin L., 525 Chou, Joany, 605 Hennessy, Kevin, 453 Livingston, David M., 692 Chytil, Anna, 31 Highlander, S. L., 142 Lodmell, Donald L., 514 Quintrell, Nancy, 172 Clark, Thomas, 728 Hirai, Kanji, 154 Look, A. Thomas, 224 Cole, Michael D., 276 Hirt, Bernhard, 8, 564 Rabson, Arnold, 284 Colledge, William H., 384 Ho, David D., 181 Macino, G., 500 Rabson, Arnold B., 545 Collins, Peter L., 646 Hoffman, Paul M., 234 Manger, Ron, 66 Rasheed, Suraiya, 66 Corallini, A., 500 Holland, T. C., 142 Maniloff, Jack, 584 Ratiarson, Annick, 655 Cremisi, Chantal, 761 Holmberg, Charles, 98 Marchioli, Carmine C., 216 Raymond, Victoria W., 755 Cywinski, Anita, 354 Horvath, Jozsef, 189 Markham, Alexander F., 384 Reddy, M., 249 Houweling, A., 684 Markland, William, 82, 384 Reinsch, S. S., 45 Dalziel, R. G., 463 Howett, Mary K., 369 Marlin, S. D., 142 Remenick, James, 660 Dambaugh, Timothy, 453 Huang, Alice S., 210 Martin, Malcolm A., 284, 545 Reschiglian, P., 500 Darnell, J. E., Jr., 112 Hunter, Tony, 73 Mata-Gilsinger, Mireille, 551 Resnick, Robert, 669 i ii AUTHOR INDEX J. VIROL.

Rettenmier, Carl W., 224 Sedlacek, Thomas V., 369 Taylor, John M., 354 Watson, Roger J., 635 Rezelman, Geertje, 50 Sefton, Bartholomew M., 73 Templeton, Joe W., 98 Waxham, M. Neal, 392 Rhoades, Marc, 203 Shank, P. R., 45 ter Meulen, Volker, 472 Weber, Joseph, 189 Rice, Nancy R., 120 Sharp, Phillip A., 746 Terry, Robert W., 163 Wellink, Joan, 50 Rickinson, Alan, 453 Sharp, R. Mark, 98 Thomas, Adri A. M., 479 Welsh, Raymond M., 735 Ritzenthaler, Paul, 551 Shaul, Yosef, 731 Thomas, Christopher Y., 23 Wertz, Gail W., 751 Riviere, Yves, 363 Sherr, Charles J., 224 Thomsen, A. Randrup, 428 Westphal, Heiner, 420 Robakis, Nickolaos K., 676 Simek, Stephanie L., 120 Timmins, James G., 216 Whealy, Mary E., 635 Robbins, Alan K., 635 Sithole, 1., 411 Trautwetter, Annie, 551 Wheeler, Esther F., 224 Robinson, H. L., 45 Skalka, Anna Marie, 163 Tsukamoto, Ann S., 14 Wiedbrauk, Danny L., 514 Roby, Clinton, 714 Sladek, Todd L., 584 Tyler, Kenneth L., 90 Willey, Ronald, 284 Rohrschneider, Larry, 66 Smith, Alan E., 82, 384 Tzeng, E., 59 Wirak, Dana O., 619 Roizman, Bernard, 494 Smith, Rosalind, 535 Wisniewski, Henryk M., 676 Rose, John K., 486 Sodroski, Joseph, 181, 743 Ueda, Shigeharu, 154 Wolinsky, Jerry S., 392 Rosen, Craig, 181 Soong, Meei-Meei, 556 Upton, C., 249 Wong, P. K. Y., 59 Rosenberg, Martin, 420 Soussi, Thierry, 740 Woodgett, Caroline, 486 Roth, Monica J., 328 Spector, Deborah H., 591 van der Eb, A. J., 684 Woodland, Ellen, 453 Roussel, Martine F., 224 Spriggs, Dale R., 90 van Drunen Littel-van den Woodrow, David, 728 Roux, Laurent, 132 Spriggs, Melanie K., 646 Hurk, Sylvia, 401 Wu, Carol Ann, 308, 318 Rubenstein, Richard, 676 Steele, Paul E., 545 van Kranen, H. J., 684 Wychowski, Czeslaw, 490 Rutter, William J., 731 Stephens, Robert M., 120 Vass-Marengo, Judit, 655 Ruyechan, William T., 31, 660 Straus, Steven E., 660 Velicer, L. F., 411 Yamamoto, Teiji, 242 Stubblefield, Elton, 172 Vrijsen, Raf, 479 Yamanouchi, Kazuya, 168 Sahli, Roland, 564 Sugawara, Keisin, 176 Yancey, Robert J., Jr., 216 Sauer, Monica K., 292 Symonds, Geoff, 172 Walker, Mary H., 224 Yewdell, Jon W., 444 Scherneck, S., 500 Wallis, John, 574 Yoshiike, Kunito, 260, 531 Schonberg, Steven, 731 Talbot, P. J., 463 Wang, Fred, 453 Yuen, P. H., 59 Schrier, Rachel D., 127 Tamashiro, Joyce C., 591 Wang, Lu-Hai, 556 Scott, Martin L., 434 Tan, Tse-Hua, 574 Wassarman, Paul M., 619 Zaino, Richard J., 369 Scraba, D., 249 Tanese, Naoko, 328, 743 Watanabe, Sumie, 260 Zarling, Joyce M., 506 SUBJECT INDEX VOLUME 59

Abelson analysis of single-site mutants, 203 pression, 127 transformation of T-lymphoid cells, 434 interruption-deficient mutants, 203 Acholeplasma laidlawii B. aneurinolyticus bacteriophage XBA1 DNA mycoplasma virus L2 characterization of bacteriocinlike bacteriophage T5 isolation of insertion variants and killing activity, 103 site-specific single-chain interruption, miniviruses, 584 L. lactis bacteriophage LL-H 203 Acquired immunodeficiency syndrome- characterization, 551 virus type 1 associated restriction mapping, 551 chromosomal organization during ner- transfected human and nonhuman cells mycoplasma virus L2 vous system infection, 764 production with infectious molecular isolation of insertion variants and DNA-binding properties clone, 284 miniviruses, 584 simian virus 40 Adenoviruses BK virus characterization, 740 ElA product transcriptional control region DNA-binding protein expression in Escherichia coli, 420 characterization, 260 herpes simplex virus group C DNA sequences evolutionary changes in deletion characterization of temperature- persistence in human lymphoid cells, mutant, 260 sensitive strain, 31 189 variant IR from human tumor DNA cleavage-packaging transcription termination regions effect on small-t expression, herpes simplex virus mapping, 112 500 mechanism of, 605 Adenovirus, group C molecular and biological properties, DNA fragments DNA sequences 500 varicella-zoster virus gene persistence in human lymphoid cells, Bovine herpesvirus 1 homology to herpes simplex virus 189 type 1 glycoprotein C, 660 Adenovirus type 2 analysis by monoclonal antibodies, DNA hybridization early region 1A proteins 401 group C adenovirus major site, 14 proposed nomenclature system, 401 sequences in human lymphoid cells, Adenovirus types 5 and 12 synthesis and processing, 401 189 activity of ElA regions Bunyaviruses mouse mammary tumor virus transformation with Ha-ras , genetics of reassortment detection of exogenous sequences in 684 virulence of La Crosse virus, 1 lymphoid cells, 159 Aleutian disease virus retroviruslike elements in quail interferon response in mink, 514 cDNA expression characterization, 354 Arenaviruses poliovirus type 1 plasmids DNA integration lymphocytic choriomeningitis virus replication in simian cells, 490 genetic reassortants and interferon, Chickens chromosome-specific satellite 363 endogenous retroviral family sequences, 731 pathogenesis, 363 cloning and characterization, 669 DNA sequences Pichinde virus infection in mice Coronaviruses novel retroviruslike family in mice interferon-mediated liver necrosis, murine hepatitis virus type 4 glycopro- isolation and characterization, 301 728 tein E2 variants DNA transfer pathogenesis, 728 effect on neurovirulence, 463 simian virus 40 Attachment sites Cowpea mosaic virus T-antigen-negative tumor cells, 628 encephalomyocarditis virus bottom-component RNA-encoded poly- human erythrocytes, 768 protein Ecotropic AKR SL3-3 murine leukemia Avian erythroblastosis virus proteolytic processing sites, 50 virus chromosomal localization of transduced Cytomegaloviruses in vivo formation of envelope gene proto-, 172 simian cytomegalovirus glycoproteins recombinants, 23 erbB coding region lectin-binding properties, 703 Ecotropic NB-tropic murine leukemia mutagenesis, 525 sensitivities to glycosidases, 703 virus oncogenic transformation, 525 virions, noninfectious enveloped parti- characterization of temperature-sens- Avian leukosis virus cles, and dense bodies of human itive isolate, 234 endogenous viruses in ev- chickens cytomegalovirus E26 leukemia virus cloning and characterization, 669 characterization of phosphoproteins, chromosomal localization of transduced sequence of osteopetrosis-inducing 714 proto-oncogenes, 172 region, 45 protein kinase activity, 714 Encephalomyocarditis virus Avian myeloblastosis virus Cytomegalovirus, human glycophorin A receptor v-myb molecular clones cytotoxic T-lymphocyte activity attchment site on human expression, 267 antigenic stimulation and immunosup- erythrocytes, 768 Avian sarcoma virus pression, 127 Endogenous proviruses conserved cis-acting sequence protein kinase activity mouse mammary tumor virus packaging requirement, 163 detection with murine monoclonal restriction maps, 535 antibodies, 185 segregation patterns, 535 Bacillus aneurinolyticus bacteriophage strain AD169 a sequence Endogenous ,BA1 terminal structure and heterogeneity, sequences in the ev- chicken characterization of bacteriocinlike kill- 591 cloning and characterization, 669 ing activity, 103 Cytotoxic T lymphocytes Endogenous retroviruses, human Bacteriophages cells from virus-infected or interferon- cloned full-length sequences bacteriophage T4 treated mice amplification and chromosomal dis- nucleotide sequence of thioredoxin susceptibility, 735 persion, 545 gene, 759 human cytomegalovirus characterization, 545 bacteriophage T5 antigenic stimulation and irnmunosup- Envelope gene recombinants iii iv SUBJECT INDEX VOL. 59, 1986

ecotropic AKR SL3-3 murine leukemia DNA cleavage-packaging mechanism, Human T-cell clones virus 605 herpes simplex virus-specific clones in vivo recombination, 23 glycoproteins of bovine herpesvirus 1 expression of glycoprotein D in Epstein-Barr virus analysis by monoclonal antibodies, virus recombinant, 506 dual antibody-probing technique 401 detection of different , 522 proposed nomenclature system, 401 Immunoreactivity changes polypeptide differentiation from synthesis and processing, 401 Sendai virus herpes simplex virus infection, 522 herpes simplex virus type 1 HN and Fo glycoproteins, 132 nuclear protein 2 expression, 453 isolation and replication, 494 A virus Exogenous mouse mammary tumor virus recombinants with different isomeric measurement of rates detection in lymphoid cells, 159 arrangements, 494 comparison with poliovirus type 1, human cytomegalovirus 377 Feline leukemia virus antigenic stimulation and immunosup- Insect vectors v-fms oncogene product pression, 127 wound tumor virus amino-terminal domain, 224 cytotoxic T-lymphocyte activity, 127 regulation of expression, 195 synthesis of transforming glycopro- virion-associated protein with kinase Interferon tein, 224 activity, 185 Aleutian disease virus Feline sarcoma virus human cytomegalovirus strain AD169 a response in normal and infected plasma membrane and detergent-insol- sequence mink, 514 uble matrix terminal structure and heterogeneity, cells from virus-infected or interferon- location offgr gene product, 66 591 treated mice Feline sarcoma virus strain McDonough Marek's disease virus susceptibility to cytotoxic T lympho- v-fms oncogene product identification of virus-specific cytes, 735 amino-terminal domain, 224 polypeptides with monoclonal lymphocytic choriomeningitis virus synthesis of transforming glycopro- antibodies, 154 genetic reassortants, 363 tein, 224 Marek's disease virus B antigen pathogenesis, 363 molecular identification and charac- Pichinde virus infection in mice Glycophorin terization, 411 pathogenesis, 728 encephalomyocarditis virus receptors pseudorabies virus attachment site on human erythro- cis functions, 318 La Crosse virus cytes, 768 defective interfering particles, 308 genetics of reassortment nonessential glycoprotein gene, 635 polygenic control of virulence, 1 Hepatitis B virus replication and cleavage-encapsid- Lactobacillus lactis bacteriophage LL-H chromosome-specific satellite sequences ation, 308, 318 physical and genetic characterization, DNA integration, 731 pseudorabies virus glycoprotein gp5O 551 expression of core antigen gene in S. DNA sequence, 216 Lentiviruses cerevisiae N-linked glycosylation, 216 visna virus neutralizing antibodies polypeptide synthesis, 176 varicella-zoster virus glycoprotein gene mechanism of action and role in virus Herpes simplex virus homology to herpes simplex virus persistance, 37 characterization of temperature-sens- type 1 glycoprotein C, 660 Lymphocytic choriomeningitis virus itive DNA-binding protein, 31 HTLV-IlI/LAV cells from virus-infected or interferon- dual antibody-probing technique identification of trans activator tatIll treated mice detection of different antigens, 522 protein, 181 susceptibility to cytotoxic T lympho- polypeptide differentiation from Ep- production cytes, 735 stein-Barr virus infection, 522 expression with bacterial vector, 743 genetic reassortants functional domains within a sequence Human adenoviruses pathogenesis, 363 DNA cleavage-packaging mechanism, early region IA proteins role of interferon, 363 605 major phosphorylation site, 14 hemopoietic dysfunction sequences, 605 Human adenovirus type 12 mechanisms, 428 monoclonal antibody-resistant mutants ElA protein product natural killer cell activation, 428 antigenic variation in glycoprotein B, expression in Escherichia coli, 420 142 Human cytomegalovirus Marek's disease herpesvirus retrograde axoplasmic transport protein kinase activity B antigen glycoprotein exadication of virus in ganglionic detection with murine monoclonal molecular identification and charac- cells, 242 antibodies, 185 terization, 411 Herpes simplex virus type 1 strain AD169 a sequence Marek's disease virus glycoprotein D terminal structure and heterogeneity, radioimmunoprecipitation with mono- expression by recombinant vaccinia 591 clonal antibodies virus, 506 virions, noninfectious enveloped parti- identification of virus-specific infection of the mouse central nervous cles, and dense bodies polypeptides, 154 system characterization of phosphoproteins, virus chromosomal organization of viral 714 expression of defective genes genome, 764 protein kinase activity, 714 persistence in brain tissues, 472 recombinants with different isomeric Human papillomavirus type 11 Mice arrangements condylomata acuminata extract BALB/c mammary gland development isolation and replication, 494 transformation of human skin, 369 mouse mammary tumor virus expres- Herpesviruses Human parainfluenza virus type 3 sion, 518 Epstein-Barr and herpes simplex viruses analysis of structural proteins c-myc retrovirus detection of different antigens, 522 characterization of mRNA, 646 construction and characterization, 276 dual antibody-probing technique, 522 determination of intergenic tumorigenesis, 276 Epstein-Barr virus sequences, 646 minute virus of mice nuclear protein 2 expression, 453 genetic map, 646 pathogenicity of variant strains on functional domains within a sequence polypeptide coding assignments, 646 T-cell function, 8 J. VIROL. SUBJECT INDEX v

mouse hepatitis virus antibodies. 392 activity of wound tumor virus protective effects of monoclonal anti- intracellular maturation. 392 regulation of expression. 195 bodies, 168 Murine hepatitis virus type 4 Poliovirus novel retroviruslike family glycoprotein E2 alteration interaction with mono- and polyclonal isolation and characterization, 301 effect on neurovirulence. 463 antibodies Pichinde virus infection Mutation rates neutralization and aggregation. 479 interferon-mediated liver necrosis, influenza A and poliovirus type 1 Poliovirus type 1 728 measurement, 377 infectious plasmids pathogenesis. 728 Mycoplasma virus L2 replication in simian cells, 490 Middle-T antigen insertion variants and miniviruses measurement of mutation rates polyomavirus isolation, 584 comparison with influenza A virus, membrane-binding domain mutagene- 377 sis, 82 Oncogene expression Polyclonal antibodies Mill Hill 2 virus mutants interaction with poliovirus chromosomal localization of transduced action of src-specific monoclonal anti- neutralization and aggregation. 479 proto-oncogenes, 172 bodies. 755 Polyomaviruses Minute virus of mice localization of conserved and endogenous proviral units splice junctions in mRNAs nonconserved epitopes. 755 restriction maps. 535 sequence, 564 Oncogenes segregation patterns. 535 T-cell function avian mvc alleles human BK virus pathogenicity of variant strains. 8 structure and transforming function. evolutionary changes in deletion Moloney murine leukemia virus 341 mutant. 260 antisera against E. co/i fusion proteins feline sarcoma virus large T antigens analysis of gene products, 328 location of fgr gene product. 66 immortalization of primary cells, 746 paralytogenic mutant of tsl plasma membrane and detergent-inso- middle-T antigen localization of neurovirulent determi- luble matrix. 66 membrane-binding domain mutagene- nants, 59 v-mvl-h molecular clones sis, 82 progressive neurodegenerative disease expression. 267 middle-T antigen sequences characterization of temperature- Oncogenic retroviruses site-directed mutagenesis. 384 sensitive isolate, 234 Rous sarcoma virus transformation- transformation by tyrosines 315 and Monkey B-lymphotropic papovavirus defective deletion mutant 250). 384 VP-1 gene c-src sequence transduction. 556 middle T tumorigenesis growth in T-lymphoblastoid cells. 531 Oncogenic transformation complemented by simian virus 40 Monoclonal antibodies adenovirus types 5 and 12 EIA regions mutant. 655 herpes simplex virus activity with Ha-ras oncogene. 684 monkey B-lymphotropic papovavirus antigenic variation in glycoprotein B. Osteopetrosis growth in T-lymphoblastoid cells. 531 142 avian leukosis virus VP-1 gene mutations. 531 interaction with poliovirus miapping of osteopetrosis-inducing T-antigen expression neutralization and aggregation, 479 variants. 45 cycloheximide inhibits protein synthe- Marek's disease virus serotypes sis. 761 identification of virus-specific Papovaviruses negative regulation in embryonal polypeptides, 154 BK virus-IR variant carcinoma cells. 761 mouse hepatitis virus effect on small-t antigen expression. Poxvirus protective effects, 168 500 vaccinia and Shope fibroma viruses virus molecular and biological properties. deletion analysis of cloned hemagglutinin-neuraminidase glyco- 500 palindromic telomeres. 249 protein human BK virus replication and resolution. 249 detection of changes, 392 evolutionary changes in deletion Prague Rous sarcoma virus intracellular maturation. 392 mutant. 260 transforming protein murine hepatitis virus type 4 glycopro- Papillomaviruses tyrosine phosphorylation. 73 tein E2 variants human papillomavirus type 11 Protein effect on neurovirulence. 463 transformation of human skin. 369 comparison of normal and transformed p53 protein expression Papovavirus. monkey B-lymphotropic cell lines comparison in human and murine T- VP-1 gene mutation expression. 444 cell lines, 444 growth in T-lymphoblastoid cells, 531 monoclonal antibody analysis. 444 Mouse hepatitis virus Paramyxoviruses Pseudorabies virus nucleocapsid proteins and major enve- human parainfluenza virus type 3 cis functions lope glycoproteins genetic map. 646 replication and cleavage-encapsid- protective effects of monoclonal anti- intergenic sequences. 646 ation. 318 bodies, 168 mRNAs. 646 defective interfering particles Mouse mammary tumor virus polypeptide coding assignments. 646 replication and cleavage-encapsid- BALB/c mammary gland development Parvoviruses ation. 308 differential endogenous gene expres- Aleutian disease virus glycoprotein gill gene sion. 518 interferon response in mink, 514 nonessential role for growth. 635 detection of exogenous sequences in minute virus of mice glycoprotein gp5O lymphoid cells, 159 pathogenicity of variant strains on DNA sequence. 216 mRNA T-cell function, 8 N-linked glycosylation. 216 minute virus of mice sequence of mRNA splice junctions. sequence of splice junctions, 564 564 Rabies virus Pichinde virus antibody response to vaccination hemagglutinin-neuraminidase glycopro- interferon-mediated liver necrosis genetic control of resistance. 98 tein pathogenesis in C3HeB/Fej mice. 728 Rat model change detection with monoclonal Plant viruses herpes simplex virus vi SUB3JECT INDEX VOL. 59, 1986

axoplasmic transport of doxorubicin, Retroviruses, mammalian large T-antigen-p53 , 242 Moloney murine leukemia virus 574 persistence in ganglionic cells, 242 analysis of pol gene products, 328 T-antigen-negative tumor cells Reassortant viruses antisera against E. coli fusion immunologic selection for, 628 lymphocytic choriomeningitis virus proteins, 328 transformation, 628 pathogenesis, 363 RNA, bottom component T-antigen transport-defective mutant role of interferon, 363 cowpea mosaic virus complementation of polyomavirus polygenic control of virulence proteolytic processing sites, 50 middle T, 655 La Crosse virus, 1 RNA patterns viral capsid protein reovirus type 3 (Dearing) human reassortant DNA-binding properties, 740 pathogenesis of a variant strain, 90 serological characterization, 510 Subacute sclerosing panencephalitis Recombinant retroviruses RNA replication defective measles virus genes large T antigens of simian virus 40 and vesicular stomatitis virus persistence in brain tissues, 472 polyomavirus properties of N-NS protein immortalization of primary cells, 746 complexes, 751 Temperature-dependent alterations Reovirus type 3 (Dearing) Rodent cells herpes simplex virus pathogenesis of a variant strain, 90 Epstein-Barr virus antigenic variation in glycoprotein B3, Resistance to rabies virus infection nuclear protein 2 expression, 453 142 antibody response to vaccination Rotaviruses monoclonal antibody-resistant mu- genetic control of resistance, 98 analysis of human reassortants tants, 142 Reticuloendotheliosis virus strain T serological characterization, 510 Temperature-sensitive mutant transformed lymphoid cells Rous sarcoma virus Moloney murine leukemia virus expression in Escherichia coli, 120 deletion mutants localization of neurovirulent determi- localization of v-rel protein, 120 activity of src-specific monoclonal nants, 59 Retroviruses antibodies, 755 Temperature-sensitive 045 mutant Abelson murine leukemia virus localization of conserved and vesicular stomatitis virus transformation of T-lymphoid cells, nonconserved epitopes, 755 intracellular conversion of glycopro- 434 retrovirus-related sequences in Japanese tein, 210 AIDS-associated retrovirus quail Terminal sequences transfection with infectious molecular characterization, 354 human cytomegalovirus strain AD169 clone, 284 transformation-defective deletion structure and heterogeneity, 591 avian erythroblastosis virus mutant, 556 Thioredoxin gene mutant v-erbB protein, 525 c-src sequence transduction, 556 bacteriophage T4 oncogenic transformation, 525 transforming protein nucleotide sequence and overproduc- avian oncogenic myc alleles phosphorylation, 73 tion, 759 structure and transforming function, serine 17 phosphorylation, 73 Transcription termination 341 adenovirus c-myc oncogene construction Saccharomyces cerevisiae cells mapping RNA termination regions, tumorigenesis, 276 hepatitis B virus 112 HTLV-III/LAV core antigen expression, 176 Tumor antigen expression of reverse transcriptase, Scrapie-associated fibrils polyomavirus expression in embryonal 743 antigenic relationships of protease-resis- carcinoma cells identification of tatIlI protein, 181 tant proteins cycloheximide inhibits protein synthe- Mill Hill 2 and E26 leukemia viruses comparison of strains, 676 sis, 761 chromosomal localization of Sendai virus negative regulation, 761 transduced proto-oncogenes, 172 HN and Fo glycoproteins polyomavirus middle T novel retroviruslike family in mice immunoreactivity changes, 132 complementation by simian virus 40 isolation and characterization, 301 Shope fibroma virus mutant, 655 reticuloendotheliosis virus strain T deletion analysis of cloned palindromic simian virus 40 expression of Escherichia coli, 120 telomeres early and late , 619 localization of v-rel protein, 120 replication and resolution, 249 expression in mammalian germ cells, visna virus neutralizing antibodies Simian cytomegalovirus 619 mechanism of action and role in virus glycoproteins selection for T-antigen-negative tumor persistence, 37 lectin-binding properties, 703 cells, 628 v-myb molecular clones sensitivities to glycosidases, 703 transformation, 628 expression, 267 Simian sarcoma virus simian virus 40 and polyomavirus v-sis oncogene v-sis oncogene immortalization of primary cells, 746 deletions in N-terminal coding region, deletions in N-terminal coding region, simian virus 40 small t 292 292 construction of adsorbents, 692 minimal transforming region, 292 minimal transforming region, 292 isolation of specific binding proteins, Retroviruses, avian Simian virus 40 692 avian sarcoma virus packaging require- cellular proteins that bind specifically to Tyrosine kinase activity ment small t polyomavirus middle-T antigen role of conserved cis-acting sequence, construction of adsorbents, 692 transforming ability, 384 163 isolation, 692 Rous sarcoma virus-related sequences large- and small-tumor antigen Vaccinia virus in Japanese quail early and late gene expression, 619 deletion analysis of cloned palindromic characterization, 354 expression in mammalian germ cells, telomeres Retroviruses, human 619 replication and resolution, 249 full-length endogenous sequences large T antigens herpes simplex virus glycoprotein D amplification and chromosomal immortalization of primary cells, 746 expression, 506 dispersion, 545 p53 cDNA clone Varicella-zoster virus characterization, 545 identification, 574 homology to herpes simplex virus type J. VIROL. SUBJECT INDEX vii

1 glycoprotein C plexes neutralizing antibodies glycoprotein gene DNA repeats, 660 properties in an in vitro system, 751 mechanism of action and role in virus Vesicular stomatitis virus temperature-sensitive 045 mutant persistence, 37 fusion activity of glycoprotein characterization, 210 oligonucleotide-directed mutagenesis, intracellular conversion of glycopro- Wound tumor virus 486 tein, 210 translational activity of viral transcripts N and NS proteins form multiple com- Visna virus regulation of expression, 195 ANNOUNCING SCOPE CHANGES FOR THE JOURNAL OF VIROLOGY

The following is a description of the scope for the Journal of Virology as recently refined by the editors. The Journal of Virology is devoted to the dissemination of fundamental knowledge concerning the viruses of bacteria, plants, and animals. Investigators in all areas of basic virology are invited to submit reports of original research that uses the approaches of biochemistry, biophysics, cell biology, genetics, immunology, molecular biology, morphology, physiology, and pathogenesis and immunity. The original articles should contain experimental observations that address a hypothesis, lead to new concepts, and indicate new directions in research. The journal will not publish papers that simply provide a new restriction map or nucleotide sequence or report the isolation of monoclonal antibodies, a viral variant, or a new strain. Such information or reagents must instead be used in further experimentation to test an idea or relate a clear set of novel conclusions that derive from these data. The Journal of Virologyspecifically encourages publications relating the viruses under study to their host cells or organisms. In recognition of this emphasis, the sections of the journal relating to viral pathogenesis and immunity and to virus-cell interactions have been specifically set aside and identified in the table of contents. The editors wish to promote the publication of research done at the cell biology-virology-organismic biology interface. ASM publishes a number of journals covering various aspects of microbiology. Each journal has a prescribed scope that must be considered in determining where to publish each manuscript. The following guidelines may be of assistance. * The Journal of Virology will consider papers that describe the use of antiviral agents in elucidating the basic biological processes of viruses and host cells. Papers dealing with other aspects of antiviral agents and chemotherapy will be considered for Antimicrobial Agents and Chemotherapy. * Manuscripts describing new methods or improvements in media and culture conditions will not be considered by the Journal of Virology unless the procedures are applied to the study of basic problems in virology or cell biology. Such manuscripts are more appropriate for Applied and Environmental Microbiology or the Journal of Clinical Microbiology. By the same token, manuscripts dealing with methods for the production of monoclonal antibodies will not be considered unless the methods have been used to address fundamental questions. * Manuscripts dealing with clinical investigations, excluding those concerned with the activities of antiviral agents, should be submitted to the Journal of Clinical Microbiology. Manuscripts dealing with ecology or environmental studies are more appropriate for Applied and Environmental Microbiology. Questions about these guidelines may be directed to the editor in chief of the journal being considered. Note that a manuscript rejected by one ASM journal on scientific grounds or on the basis of its general suitability for publication is considered rejected by all other ASM journals. a. *

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