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Rabbit Anti-FAM162A/FITC Conjugated antibody
SL14741R-FITC
Product Name: Anti-FAM162A/FITC Chinese Name: FITC标记的FAM162A蛋白抗体 C3orf28; Chromosome 3 open reading frame 28; DC16; E2-induced gene 5 protein; E2IG5; F162A_HUMAN; Fam162a; Family with sequence similarity 162, member A1; Alias: Growth and transformation-dependent protein; HGTD P; HIF-1 alpha-responsive proapoptotic molecule; OTTHUMP00000215578; OTTHUMP00000215579; OTTHUMP00000215580; Protein FAM162A. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Pig,Horse, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 17kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human FAM162A Lsotype: IgGwww.sunlongbiotech.com Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. background: HGTD-P (human growth and transformation-dependent protein), also known as E2IG5 or FAM162A, is a 154 amino acid single-pass membrane protein belonging to the Product Detail: UPF0389 family. Considered a proapoptotic protein, HGTD-P is an effector of cell death induced by hypoxia-ischemia (HI) and is therefore considered a potential target in treating HI-induced brain damage. HGTD-P localizes to the mitochondria and, when overexpressed, induces the mitochondrial permeability transition by interacting with voltage dependent anion channels. HGTD-P facilitates apoptotic cell death via the mitochondrial apoptotic cascades, including permeability transition, cytochrome c release and caspase 9 activation. HGTD-P is regulated and activated by HIF-1?through a hypoxia-responsive element on the HGTD-P promoter region.
Subcellular Location: Membrane.
Similarity: Belongs to the UPF0389 family.
Database links:
Entrez Gene: 26355 Human
Omim: 608017 Human
SwissProt: Q96A26 Human
Unigene: 584881 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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