Effect of Nephroprotective Potentials of Siddha Medicinal Herbs – a Current Status
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ISSN: 2455-944X Int. J. Curr. Res. Biol. Med. (2019). 4(2): 12-23 INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN BIOLOGY AND MEDICINE ISSN: 2455-944X www.darshanpublishers.com Volume 4, Issue 2 - 2019 Review Article DOI: http://dx.doi.org/10.22192/ijcrbm.2019.04.02.003 Effect of Nephroprotective potentials of Siddha Medicinal Herbs – A current status. Vijaya Nirmala R1, Abinaya R1. 1Post Graduate, Department of Gunapadam (Pharmacology), Govt Siddha Medical College, Chennai. Abstract Siddha system of medicine is one of the medical treatments which bring out the effective treatment for various diseases. It constitutes herbal preparation without side-effects. Among the modern world Nephro toxicity is a major problem which has threadened the human population. Thus an attempt was made in this review to reduce the nephro toxicities. In this paper the author compile the review of certain herbs with their phyto-constitutions which can protect the kidney from its toxicity. Keywords: Siddha, Nephro toxicity, Nephro-protective, Herbs Introduction Siddha system of medicine is the one of the traditional In recent decades there is an increased rate of medicinal system to mankind and they can prepared mortality have been seen. In order reduce the medicines through the siddha system more than 10000 increased risk Nephro toxicity an attempt was made to years ago[1]. compile this review. In this review author compile certain medicinal plants which protect the kidney by Siddha system of medicine in practiced particularly in inducing certain Nephrotoxic substances such as south Indian people. It maintains distinctive identity of Cisplastin, Gentamycin, Acetaminophen, Cadmium, own. This system closely identified with Tamil Fluride. The herbs which has the potential of civilization. This system constitutes with no toxic protecting the kidney are as follows Aerva lanata, effects of herbal preparations. The word Siddha comes Aegle marmelos, Acorus calamus, Anethum from Siddhi that means achievements. Siddhars were graveolens, Abutilon indicum, Boerhaavia diffusa, the supernatural scientists with supreme knowledge[2]. Cassia auriculata, Carica papaya, Curcuma longa, Emblica officinalis , Ficus religiosa, Lepidium The substances which cause Nephroprotective actions sativum, Glycyrrhiza glabra , Moringa oleifera, must show the nephroprotective property against Nigella sativa, Rubia cardifolia Linn, Ocimum nephrotoxicity which is induced by Cisplastin, sanctum, Pongamia pinnata , Strychnos potatorum , Gentamicin. Naturally herbs have the curative Tamarindus indica, Withania somnifera. properties due to the presence of various complex chemical substances. The ancient traditional literatures has prescribed various herbs for treating renal diseases[3]. 12 ISSN: 2455-944X Int. J. Curr. Res. Biol. Med. (2019). 4(2): 12-23 Nephrotoxicity agents: Streptomycin.Miscellaneous : Radiocontrast agents: Non-steroidal anti-inflammatory agents (NSAID’s): Many drugs, Chemicals and Certain diagnostic Ibuprofen, Indomethacin, Aspirin etc[4]. techniques are responsible for causing renal damage. Here authors have mentioned certain compounds Animal models used in experimental studies: which cause Nephrotoxicity. In Vivo Models: Heavy metals: Mercury, lead, Arsenic and GM treated albino rat Bismuth.Antineoplastic agents :Alkylating agents: Cisplatin treated albino rats Cisplatin, cyclophosphamide. Nitrosoureas: Cisplatin treated rabbits Streptozotocin, Carmustine, Lomustine & Semustine. GM treated guinea pigs Antimetabolites: Methotrexate, Cytosine Arabinose, 6- Mercuric chloride treated mice thioguanine, 5-flurouracil.Antitumor antibiotics: Ethylene glycol treated mice Mitomycin, Mithramycin, Doxorubicin. Biologic agents: Recombinant leukocyte and interferon. In Vitro Models Antimicrobial agents: Tetracycline, Acyclovir, Pentamidine, Sulphadiazine, Trimethoprin, Vero cells[5] Rifampicin, Amphotericin B Aminoglycosides : Gentamycin, Amikacin, Kanamycin, Table No:1 Chemical constituents of some nephroprotective plants: English Parts S.No Botanical name Family Tamil name Chemical constituents name used Botulin, β-sitosterol, Amyrin, Hentriacontane, Campesterol, Stigmasterol, Whole 1. Aerva lanata Amaranthaceae Siruganpeelai Balipoovu[6] Kaempferol, Starch, plant Propionic acid, β- carboline-I, Aervoside, Aervolanine[7] Aegeline, Agelinine, Rutin, Sterol, β-sitosterol, β-D-glucoside, Mamesinine, Lupeol, Aegle marmelos Rutaceaeae Bael Holy Leaves 2. Villam Tannins, Phlobatannins, fruit tree[6] Flavonoids, Umbelliferone, Quercetin and Volatile oils[8]. Monoterpene, Aerial Sesquiterpene, Phenyl 3. Acorus calamus Araceae Vasambu Sweet flag[6] parts propanoid, Flavonoids, Quinone and basarone[9]. alkaloids, flavonoids, The dill, Anethum tannins, saponins, cardiac 4. Umbelliferae Sathakuppai Gardendill, graveolens seeds glycosides, terpenoids, Anet[6] anthocyanin[10] Indian mush Whole Saponins, Flavonoids and 5. Abutilon indicum Malvaceae Thuthi [6] [11] mallon plant Tannins . 13 ISSN: 2455-944X Int. J. Curr. Res. Biol. Med. (2019). 4(2): 12-23 Flavonoids, Alkaloids, Steroids, Hog weed, Triterpenoids, Lipids, 6. Boerhaavia diffusa Nyctaginaceae Mookirattai [6] Root Pig weed Lignins, carbohydrates, Proteins and Glycoproteins[12]. Tannins, Di-(2-ethyl) Cassia auriculata Fabaceae The tanners Roots hexyl phthalate, Alkaloids, 7. Aavaarai cassia[6] Resins, Ca2+ and Phosphorous[13]. Flavanoids, Phenols, Alkaloids, Protein, Sterols, Terpenoids, 8. Carica papaya Caricaceae Pappaali Pappaya[6] Seed Carbohydrates, Steroids, Tannins, Glycosides, Terpins and Saponins[14]. Curcumin, Turmeric oil, Terpenoids, 9. Curcuma longa Zingeberaceae Manjal Turmeric[6] Rhizome Curcumin (Terpene), Starch and Albumnoids[15]. Vitamin-C, Carotene, Nicotinic acid, Riboflavin, D-glucose, D-fructose, Myoinositol, a Pectin with D-galacturonic acid, Darabinosyl, D-xylosyl, L- rhamnosyl, G-glycosyl, D- manosyl, D-galactosyl, Emblica officinalis Euphorbiaceae Indian Fruits 10. Nelli Embicol, Mucic and gooseberry[6] Phyllambic acid, Phellembin, Fatty acid, Leucodelphinidine, Procyanidin, 3-O-gallated Prodelphindin, Tannins, Ellagic acid, Lupeol and Oleanolic acid[16]. Peepul tree, Flavonoids, Amino acids 11. Ficus religiosa L Moraceae Arasu [6] Latex [17] Sacridfig and Tannins . 14 ISSN: 2455-944X Int. J. Curr. Res. Biol. Med. (2019). 4(2): 12-23 Volatile essential Fatty oils, Carbohydrate, Garden Lepidium Protein, Vitamin B- Brassicaceae cress, Seeds 12. sativum Aalivirai carotene, Riboflavine, Water [6] Niacin, Ascorbic acid, cress Flavonoids, Glycosides and Isothiocynates[18]. Glycyrrhizin, Glyciyrrhizic acid, Glycyrrhiza Indian Fabaceae Rhizomes Glycosides, Steroids, 13. glabra Athimathuram Jamaica [6] Glucose, Sucrose, Resin, liquorice Starch and Essential oil[19]. Vitamin A, Nicotinic acid, Ascorbic acid, Vitamin B, Fatty Horse acid, Glucose, Moringa raddish, 14. Moringaceae Murungai Seeds Sucrose, Citric acid, oleifera Drum Malic acid, stick[6] Succinic acid, Fumaric acid and Oxalic acid[20]. Alanine, L-Spinasterol, Arabic acid, Arginine, Amino acid, Aspargine, Black Aspartic acid, Carvone, Whole Nigella sativa Ranunculaceae cumin, Cystine, Cholesterol, 15. Karunjeeraaham plant Small Glutamic acid, Linoleic fennel[6] acid, Linolenic acid, Melanthin, Myristic acid, Oleic acid and Tannins[21]. Purpurin, Manjistin, Garancin, Purpuroxanthin, Resin, Rubia Indian Glucose, 16. Rubiaceae Manjitti [6] Root cardifolia Linn madder Sucrose, Triterpenes, Lucidine, Anthroquinine, Fattyacids and Gum[22]. Eugenol, Carvacrol, methyl ether, Carvacrol, Holy Ocimum Caryophyllene, Ursolic Lamiaceae Basil, Leaves 17. sanctum Thulasi acid, Apigenin, Luteolin, Sacred Ascorbic acid, Carotene, basil[6] Alkaloids, Glycosides, Saponins and Tannins [23] Flowers Pongamol, Protien, Alkaloids, Pongamia Papilionaceae Indian Flowers Tannins, Sugar, Resin 18. pinnata Pungu Beech[6] and Fatty oil (Karanjin) [24]. 15 ISSN: 2455-944X Int. J. Curr. Res. Biol. Med. (2019). 4(2): 12-23 Flavanoids, Phenols, Saponins, Alkaloids, Strychnos Loganiaceae Clearing Seeds Steroids, Tannins, 19. potatorum Thettran nut[6] Glycosides, and Lignins[25]. Polysaccharides, Balsamine, Catechin, Nasturtium, Tamarin, Phosphatidic Fruit acid, Phosphatidic choline, 20. Tamarindus indica Caesalpinaceae Puli Tamarind[6] pulp Ethanollamine, Serine, Inositol, Alkaloid, Citric acid, Tartaric acid and Pottasiumbitartrate[26]. Alkaloids (Somniferon), Withaminon, Wasamin, Sugars, Glycosides, Withania Solanaceae Winter Roots Amino acids, Essential 21. somnifera Amukkara Cherry[6] Oils, Withaniol, Hexatriacontane, Phyto sterol and oils[27]. Nephroprotective plants: Clade : Eudicots Clade : Rosids 1. Aerva lanata Order : Sapindales Family : Rutaceae Kingdom : Plantae Subfamily : Aurantioideae Clade : Angiosperms Genus : Aegle Clade : Eudicots Species : marmelos[30] Clade : Core eudicots Order : Caryophyllales Nephroprotective property: Family : Amaranthaceae Subfamily : Amaranthaceae Aqueous extract of the Aegle marmelos was Genus : Aerva administered with the doses of 250, 500 and 750 Species : lanata[28] mg/kg to the Wistar albino rats with gentamicin induced nephrotoxicity. The aqueous extract of Aegle Nephroprotective property: marmelos shows a potent nephroprotective effect with normal serum creatinine, urea and blood urea nitrogen The ethanolic extract of Aerva lanata shows a potent level[31]. nephroprotective effect with cisplastin and gentamicin induced nephrotoxicity of either sex of white albino 3. Acorus calamus rats. The extract dose levels were with 75,150 and