DOCSLIB.ORG

Download Selections from the Pharos Autumn

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Download Selections from the Pharos Autumn Alpha Omega Alpha Honor Medical Society Autumn 2014 Rush vs Cobbett THE PHAROS of Alpha Omega Alpha honor medical society Autumn 2014 “Be Worthy to Serve the Suffering” Alpha Omega Alpha Honor Medical Society Founded by William W. Root in 1902 Officers and Directors at Large Editor Richard L. Byyny, MD John Tooker, MD, MBA President Philadelphia, Pennsylvania Editor Emeritus (in memoriam) Robert J. Glaser, MD C. Bruce Alexander, MD Immediate Past President Associate Editor and Helen H. Glaser, MD Birmingham, Alabama Managing Editor Douglas S. Paauw, MD (in memoriam) President-Elect Seattle, Washington Managing Editor Debbie Lancaster Joseph W. Stubbs, MD Secretary-Treasurer Art Director and Illustrator Albany, Georgia Robert G. Atnip, MD Designer Erica Aitken Hershey, Pennsylvania Eve J. Higginbotham, SM, MD Editorial Board Philadelphia, Pennsylvania Richard B. Gunderman, MD, PhD Indianapolis, Indiana Jeremiah A. Barondess, MD Faith T. Fitzgerald, MD Stephen J. McPhee, MD Sheryl Pfeil, MD New York, New York Sacramento, California San Francisco, California Columbus, Ohio David A. Bennahum, MD Daniel Foster, MD Janice Townley Moore Albuquerque, New Mexico Dallas, Texas Young Harris, Georgia Alan G. Robinson, MD John A. Benson, Jr., MD James G. Gamble, MD, PhD Francis A. Neelon, MD Los Angeles, California Portland, Oregon Stanford, California Durham, North Carolina Wiley Souba, MD, DSc, MBA Richard Bronson, MD Dean G. Gianakos, MD William M. Rogoway, MD Hanover, New Hampshire Stony Brook, New York Lynchburg, Virginia Stanford, California Steven A. Wartman, MD, PhD John C.M. Brust, MD Jean D. Gray, MD Shaun V. Ruddy, MD Washington, DC New York, New York Halifax, Nova Scotia Richmond, Virginia Charles S. Bryan, MD David B. Hellmann, MD Bonnie Salomon, MD Columbia, South Carolina Baltimore, Maryland Medical Organization Director Robert A. Chase, MD Pascal James Imperato, MD John S. Sergent, MD Carol A. Aschenbrener, MD Stanford, California, and Brooklyn, New York Nashville, Tennessee Association of American Medical Colleges Jaffrey, New Hampshire John A. Kastor, MD Clement B. Sledge, MD Washington, DC Henry N. Claman, MD Baltimore, Maryland Marblehead, Massachussetts Denver, Colorado Henry Langhorne, MD Jan van Eys, Ph.D., MD Councilor Directors Fredric L. Coe, MD Pensacola, Florida Nashville, Tennessee Lynn M. Cleary, MD Chicago, Illinois Jenna Le, MD Abraham Verghese, MD, DSc State University of New York Upstate Medical (Hon.) Jack Coulehan, MD New York, New York University Stony Brook, New York Stanford, California Michael D. Lockshin, MD Mark J. Mendelsohn, MD Ralph Crawshaw, MD New York, New York Steven A. Wartman, MD, PhD Washington, DC University of Virginia School of Medicine Portland, Oregon Kenneth M. Ludmerer, MD Gerald Weissmann, MD Peter E. Dans, MD St. Louis, Missouri Alan G. Wasserman, MD New York, New York Baltimore, Maryland J. Joseph Marr, MD George Washington University School of David Watts, MD Lawrence L. Faltz, MD Medicine and Health Sciences Mill Valley, California Larchmont, New York Coordinator, Residency Initiatives Suzann Pershing, MD Stanford University Student Directors www.alphaomegaalpha.org Christopher Clark, MD University of Mississippi Medical School Tonya Cramer, MD Manuscripts being prepared for The Pharos should be typed double-spaced, submitted in triplicate, and conform to the format Chicago Medical School at Rosalind Franklin outlined in the manuscript submission guidelines appearing on our website: www.alphaomegaalpha.org. They are also available University of Medicine & Science from The Pharos office. Editorial material should be sent to Richard L. Byyny, MD, Editor, The Pharos, 525 Middlefield Road, Suite Laura Tisch 130, Menlo Park, California 94025. Medical College of Wisconsin Requests for reprints of individual articles should be forwarded directly to the authors. The Pharos of Alpha Omega Alpha Honor Medical Society (ISSN 0031-7179) is published quarterly by Alpha Omega Alpha Honor Medical Society, 525 Middlefield Road, Suite 130, Menlo Park, California 94025, and printed by The Ovid Bell Press, Inc., Fulton, Administrative Office Missouri 65251. Periodicals postage paid at the post office at Menlo Park, California, and at additional mailing offices. Copyright Richard L. Byyny, MD © 2014, by Alpha Omega Alpha Honor Medical Society. The contents of The Pharos can only be reproduced with the written Executive Director permission of the editor. (ISSN 0031-7179) Menlo Park, California Circulation information: The Pharos is sent to all dues-paying members of Alpha Omega Alpha at no additional cost. All correspondence relating to circulation should be directed to Ms. Debbie Lancaster, 525 Middlefield Road, Suite 130, Menlo Park, California 94025. E-mail: [email protected] Menlo Park, California 94025 Telephone: (650) 329-0291 POSTMASTER: Change service requested: Alpha Omega Alpha Honor Medical Society, 525 Middlefield Road, Suite 130, Fax: (650) 329-1618 Menlo Park, CA 94025. E-mail: [email protected] The Pharos • Volume 77 Number 4 • Autumn 2014 In This Issue DEPARTMENTS On the cover Editorial Alpha Omega Alpha Honor Medical Society Autumn 2014 2 The care of the patient See page 10 Richard L. Byyny, MD Cover illustration by Erica Aitken The physician at the movies 41 Peter E. Dans, MD Jersey Boys The Monuments Men The Train (1964) Rush vs Reviews and reflections Cobbett 46 Doctors Without Borders: Humanitarian Quests, Impossible Dreams of Médecins Sans Frontières Genesis of the Salk Institute: The Epic of Its Founders ARTICLES The Teaching Hospital: Brigham and Women’s Hospital and the Evolution of Academic Medicine David Seegal 4 Ic ne wat and other maxims of a master Letter to the editor teacher 50 2014 Fellow in Leadership Awards Peter E. Dans, MD 51 2014 Edward D. Harris 54 Professionalism Award Bleeding by the numbers 2014 Postgraduate Awards 10 Rush versus Corbbett 55 Andrew G. Shuman, MD, Marc Edelman, JD, MA, and Joseph J. Fins, MD Marjorie Sirridge, MD: 1921-2014 55 56 2014 2014 Visiting Professorships How postoperative respiratory distress 18 conspired with friendly fire to kill 2014 Volunteer Clinical Faculty “Stonewall” Jackson 58 Awards Joseph J. DuBose, MD, James I. Robertson, Jr., PhD, and Philip A. Mackowiak, MD 2014 Administrative Recognition 59 Awards Haiti journal Exhibition: “The Surgeon General 60 vs. The Marlboro Man” 26 Ken Barnes, MD POETRY Reflecting on a few well-remembered Perceptions of Ear Disorders medical eponyms 17 Thomas Balkany, MD, FACS, FAAP 34 Martin Duke, MD Breast Exam 25 Trang Diem Vu The Weight of a Marble Lullaby 37 Alyse Marie Carlson 38 Steven Krager Third Year Medical Student 40 Encounter Glenna Martin INSIDE The Robert H. Moser Pharos Editor’s BACK Prize Sandglass COVER 45 Aisha Harris Editorial The care of the patient Richard L. Byyny, MD r. Henry Kempe, author of the seminal “The Battered- and that the “scary dreams” would resolve. Child Syndrome,” was a professor of Pediatrics and Two or more times a day his doctor and other physicians MicrobiologyD and chairman of the Department of Pediatrics would make rounds. Dr. Kempe saw them as being like a at the University of Colorado from 1956 to 1980. In 1978, he school of sharks who would swim in, look at his chart, and finished a hectic and busy day of work, grabbed a full suit- watch the multiple monitors without talking to him, looking case and a heavy briefcase, and caught a flight to New York him in the face, or touching or comforting him. He watched to receive the Aldrich Award of the American Academy of them attentively to try to gain clues about whether he was Pediatrics for contributions in the field of child development. getting better or worse: did they frown, grimace, shake their He arrived at his hotel that evening, exhausted by the long day heads up or down, or yes or no? They would then swim out and travel. Shortly thereafter, he developed shortness of breath with his chart in hand. and hemoptysis. He called a colleague at NYU, who advised One day, a few days after his balloon pump had been him to go to the ER at Bellevue Hospital; he took a cab to the removed, he awoke frightened and crying. He could hear a emergency room and was admitted to the coronary care unit, loud pulsating sound. He was still intubated, so could not ask where they fortunately had an open bed, in cardiogenic shock questions, but deduced that the balloon pump must have been from an acute myocardial infarction with pulmonary edema. reinserted indicating that he was worse. His nurse could see He was intubated and on a respirator, and had a balloon pump his disturbance. She asked, “Is the sound you’re hearing dis- inserted in his aorta to assist in maintenance of his blood turbing you?” She looked at him, held his hand, and said, “That pressure. is the wrecking ball knocking down the rest of the old Bellevue With no recollection of his first two weeks in the coronary Hospital. You didn’t hear the noise on Saturday and Sunday, care unit, Dr. Kempe gradually awakened to pain and confu- but you did hear it on Friday when your aortic balloon came sion. He continued to be very confused and sleep deprived out. That was a bad time. You remember not only how painful by all that was going on in the unit, and was, in addition, that was, but you also remember how the balloon sounded fearful about his memory and reasoning losses and the delu- inside you during those rough days. I bet you are remembering sions and frightening hallucinations he experienced. The only that pain.” With her care and thoughtful reasoning about why good thing about the unit was the nursing staff. They held his he was suffering, and with her explanation, his distress disap- hands, bathed him, oriented him by looking him in the eye to peared. He gradually had fewer flashbacks—when he did the tell him his name, his situation, and where he was and what nurses would comfort and care for him.
Load more

Recommended publications
  • The Clinical Laboratories Were Not Recognized As Their Training
    Chapter Th e Clinical Laboratories (Chemistry and Hematology) Donna MacMillan and Kent B. Lewandrowski he clinical laboratories (Clinical millions of tests per year with a menu of over TChemistry and Hematology) at the Mas- 1,500 diff erent tests (including those sent to out- sachusetts General Hospital (MGH) originated side reference laboratories), and with oversight with individual physicians interested in specifi c of all point-of-care testing as well. Th is chap- diseases for which biological and therapeutic ter traces the transition from the earliest docu- clues began to emerge from laboratory tests. mented times to the present day. Over time, custom tests developed for specifi c patients were repeated for patients with similar The Early Years symptoms; in this way laboratory tests progres- Clinical laboratories had a minimal role in sively moved from research to patient care. the early years of the hospital: “For the fi rst sev- Th e chemistry laboratory at MGH has a long enty-fi ve years of its life there was nothing really history. It began as a central facility but was worthy [of] the name of a laboratory. Impor- quickly accompanied by a group of independent tant work was carried out in a hole-and-corner specialty laboratories such as the Th yroid, Endo- way” (1). Even by 1872 the laboratory measured crine and Metabolism, Blood Gases, and Lipid only approximately 6 by 10 feet. Located on the Laboratories, which led to a decentralized and ground fl oor of the Bulfi nch Building, it was complex set of separate facilities. On the other described as a “small dark room used as a labo- hand, there is little mention of hematology as a ratory where specimens of urine were taken for laboratory science until the middle of the twenti- analysis” (2) (fi gure 20.1).
    [Show full text]
  • The Electrophysiologic Basis for the Antiarrhythmic Effect of N-3 Polyunsaturated Fatty
    The Electrophysiologic Basis for the Antiarrhythmic Effect of n-3 Polyunsaturated Fatty Acids Alexander Leaf Departments of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, U.S.A. Short title: Antiarrhythmic and anticonvulsant effects of n-3 fatty acids Send correspondence to: Alexander Leaf, M.D. Massachusetts General Hospital Bldg.149, Rm 4001, 13th Street Charlestown, MA 02129 USA Tel: 617-726-5908 Fax: 617-726-6144 [email protected] 1 Summary - Studies on the antiarrhythmic actions of n-3 polyunsaturated fatty acids in fish oils (PUFA) are reported. The PUFA stabilize the electrical activity of isolated cardiac myocytes by modulating sarcolemmal ion channels, so that a stronger electrical stimulus is required to elicit an action potential and the relative refractory period is markedly prolonged. Inhibition of voltage dependent sodium currents which initiate action potentials in excitable tissues, and also inhibition of the L-type calcium currents, which initiate release of sarcoplasmic calcium stores, that increase cytosolic free calcium concentrations and activate the contractile proteins in myocytes, appear at present to be the probable major antiarrhythmic mechanism of the PUFAs It was the findings of McLennan and Charnock [1], which first conclusively demonstrated in rats that the n-3 fatty acids in fish oils prevented ischemia-induced fatal ventricular arrhythmias. Our studies sought to learn if we could confirm their findings in a reliable dog model of sudden cardiac death with Prof. George E. Billman. A surgically induced myocardial infarction was produced by ligating the left anterior decending coronary artery and an inflatable cuff was placed around the left circumflex artery.
    [Show full text]
  • Intestinal Absorption Christie, DA; Tansey, EM
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Queen Mary Research Online Intestinal absorption Christie, DA; Tansey, EM For additional information about this publication click this link. http://qmro.qmul.ac.uk/jspui/handle/123456789/2800 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] Wellcome Witnesses to Twentieth Century Medicine INTESTINAL ABSORPTION A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 February 1999 Witness Seminar Transcript edited by D A Christie and E M Tansey Introduction by Sir Christopher Booth Volume 8 – September 2000 ©The Trustee of the Wellcome Trust, London, 2000 First published by the Wellcome Trust, 2000 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 184129 017 1 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2000) Intestinal Absorption. Wellcome Witnesses to Twentieth Century Medicine, vol. 8. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Dr Derek Holdsworth Dr Peter Hanson, Dr Richard Boyd Dr Peter Williams, Professor Oliver Wrong Professor Ramsey Bronk, Professor Michael Gardner Lord Turnberg (chair), Professor Timothy Peters Dr Richard Boyd, Professor Ramsey Bronk Dr Sheila Callender (1914–2004), Professor Hermon Dowling Dr Roy Levin, Sir Christopher Booth Back cover photographs, L to R from the top: Professor Hermon Dowling, Sir Christopher Booth Professor Michael Gardner, Dr Peter Hanson, Dr Richard Boyd, Professor Ramsey Bronk Professor John Walker-Smith, Dr George Misiewicz Dr Michael Hellier Professor Roy Pounder Dr George Misiewicz Professor Oliver Wrong CONTENTS Introduction Sir Christopher Booth i Witness Seminars: Meetings and publications ii Transcript 1 List of plates Figure 1.
    [Show full text]
  • Intestinal Absorption
    Wellcome Witnesses to Twentieth Century Medicine INTESTINAL ABSORPTION A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 February 1999 Witness Seminar Transcript edited by D A Christie and E M Tansey Introduction by Sir Christopher Booth Volume 8 – September 2000 ©The Trustee of the Wellcome Trust, London, 2000 First published by the Wellcome Trust, 2000 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 184129 017 1 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2000) Intestinal Absorption. Wellcome Witnesses to Twentieth Century Medicine, vol. 8. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Dr Derek Holdsworth Dr Peter Hanson, Dr Richard Boyd Dr Peter Williams, Professor Oliver Wrong Professor Ramsey Bronk, Professor Michael Gardner Lord Turnberg (chair), Professor Timothy Peters Dr Richard Boyd, Professor Ramsey Bronk Dr Sheila Callender (1914–2004), Professor Hermon Dowling Dr Roy Levin, Sir Christopher Booth Back cover photographs, L to R from the top: Professor Hermon Dowling, Sir Christopher Booth Professor Michael Gardner, Dr Peter Hanson, Dr Richard Boyd, Professor Ramsey Bronk Professor John Walker-Smith, Dr George Misiewicz Dr Michael Hellier Professor Roy Pounder Dr George Misiewicz Professor Oliver Wrong CONTENTS Introduction Sir Christopher Booth i Witness Seminars: Meetings and publications ii Transcript 1 List of plates Figure 1. The late Professor R B Fisher setting up a demonstration of perfused small intestine. 7 Figure 2. Dr Dennis Parsons, Dr N I McNeil and Professor Leslie Turnberg at the 1983 Falk Symposium on Intestinal Absorption and Secretion in Titisee, Black Forest.
    [Show full text]
  • Effects of Federal Policies on Extracorporeal Shock Wave Lithotripsy (Part 10 Of
    Appendixes Appendix A Acknowledgments and the Health Program Advisory Committee ACKNOWLEDGMENTS The development of this case study was greatly aided by the advice of a number of people. The author and other OTA staff would like to express their appreciation to the advisory panel on Payment for Physician Services: Strategies for Medicare, to the Health Program Advisory Committee, and especially to the following individuals: Henry C. Alder Cynthia P. King American Hospital Association American Medical Association Chicago, IL Chicago, IL Charles R. Booth J. Kersten Kraft Health Care Financing Administration Northern California Kidney Stone Center Baltimore, MD Los Gates, CA Thomas W. Byrne Charles Guidice Blue Cross/Blue Shield of Massachusetts OCHAMPUS Boston, MA Aurora, CO Gary Clisham Frederic C. Jacob Medstone International, Inc. Davis, CA San Diego, CA Gerald Colvin Gerald McDonald Health Systems Agency of Southwestern Veterans Administration Pennsylvania Washington, DC Pittsburgh, PA Robert McDonough Thomas Dolan Duke University Uro-Tech Management Corp. Durham, NC Houston, TX William McGivney George Drach American Medical Association University of Arizona Chicago, IL Tucson, AZ Diane Minear Steven P. Dretler Food and Drug Administration Massachusetts General Hospital Silver Spring, MD Boston, MA Bonnie Grogan Albert G. Mulley Northern California Kidney Stone Center Massachusetts General Hospital Los Gates, CA Boston, MA Harry Heatherington Daniel Newman Health Care Financing Administration Methodist Hospital of Indiana Baltimore, MD Indianapolis, IN Alan Jenkins Eckhard Polzer University of Virginia Medical Center Dornier Medical Systems Inc. Charlottesville, VA Marietta, GA 89 90 Glenn M. Preminger James Snipe University of Texas Health Science Center OCHAMPUS Dallas, TX Aurora, CO Martin I.
    [Show full text]
  • Free, Long-Chain, Polyunsaturated Fatty Acids Reduce Membrane Electrical
    Proc. Natl. Acad. Sci. USA Vol. 92, pp. 3997-4001, April 1995 Physiology Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes (action potential/threshold/automaticity/c3 and w6 fatty acids/antiarrhythmics) JING X. KANG*, YONG-FU XIAO*t, AND ALEXANDER LEAF*t§ *Department of Medicine and the tRenal Unit, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114; and tThe Brockton/West Roxbury Veterans Affairs Medical Center, West Roxbury, MA 02132 Contributed by Alexander Leaf, January 9, 1995 ABSTRACT Because previous studies showed that poly- electrophysiology in neonatal rat cardiac myocytes. We report unsaturated fatty acids can reduce the contraction rate of here that free puFAs, but neither monounsaturated nor sat- spontaneously beating heart cells and have antiarrhythmic urated fatty acids, at 5-10 ,M significantly reduce membrane effects, we examined the effects of the fatty acids on the electrical excitability by increasing the threshold for action electrophysiology of the cardiac cycle in isolated neonatal rat potential (more positive), the resting-membrane potential cardiac myocytes. Exposure of cardiomyocytes to 10 ,lM (more negative), and the refractory-period duration in the eicosapentaenoic acid for 2-5 min markedly increased the cardiac myocytes. strength of the depolarizing current required to elicit an action potential (from 18.0 ± 2.4 pA to 26.8 ± 2.7 pA, P < 0.01) and the cycle length of excitability (from 525 ms to 1225 ms, METHODS AND MATERIALS A = 700 + 212, P < 0.05). These changes were due to an Cell Culture. Cardiac myocytes were isolated from 1-day-old increase in the threshold for action potential (from -52 mV rats using a neonatal cardiomyocyte isolation system (Worth- to -43 mV, A = 9 + 3, P < 0.05) and a more negative resting ington).
    [Show full text]
  • Supercentenarians Landscape Overview
    Supercentenarians Landscape Overview Top-100 Living Top-100 Longest-Lived Top-25 Socially and Professionally Active GERONTOLOGY RESEARCH GROUP www.aginganalytics.com www.grg.org Supercentenarians Landscape Overview Foreword 3 Top-100 Living Supercentenarians Overview 44 Preface. How Long Can Humans Live and 4 Ages of Oldest Living Supercentenarians by Country 46 the Importance of Age Validation Top-100 Living Supercentenarians Continental Executive Summary 10 47 Distribution by Gender Introduction. 26 Top-100 Living Supercentenarians Distribution by Age 50 All Validated Supercentenarians Сhapter III. Top-25 Socially and Professionally Active All Supercentenarians Region Distribution by Gender 29 52 Living Centenarians Top-25 Socially and Professionally Active Centenarians All Supercentenarians Distribution by Nations 30 53 Overview Top-25 Socially and Professionally Active Centenarians Longest-Lived Supercentenarians Distribution by Country 31 54 Distribution by Nation Top-25 Socially and Professionally Active Centenarians All Supercentenarians Distribution by Gender and Age 32 55 Gender Distribution Top-25 Socially and Professionally Active Centenarians Сhapter I. Top-100 Longest-Lived Supercentenarians 35 56 Distribution by Type of Activity Chapter IV. Profiles of Top-100 Longest-Lived Top-100 Longest-Lived Supercentenarians Overview 36 57 Supercentenarians Top-100 Longest-Lived Supercentenarians Regional 38 Chapter V. Profiles of Top-100 Living Supercentenarians 158 Distribution by Gender Top-100 Longest-Lived Supercentenarians Distribution
    [Show full text]
  • Protective Effect of Eicosapentaenoic Acid on Ouabain Toxicity in Neonatal Rat Cardiac Myocytes
    Proc. Nati. Acad. Sci. USA Vol. 87, pp. 7834-7838, October 1990 Medical Sciences Protective effect of eicosapentaenoic acid on ouabain toxicity in neonatal rat cardiac myocytes (cardiac glycoside toxicity/w-3 fatty acid effect/cytosolic calcium overload/cardiac antiarrhythmic/Na,K-ATPase inhibition) HAIFA HALLAQ*t, ALOIS SELLMAYERt, THOMAS W. SMITH§, AND ALEXANDER LEAF* *Department of Preventive Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114; tInstitut fur Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Universitat Munchen, Pettenkofer Strasse 9, 8000 Munich 2, Federal Republic of Germany; and §Cardiovascular Division, Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02114 Contributed by Alexander Leaf, June 26, 1990 ABSTRACT Isolated neonatal cardiac myocytes have been sarcolemmal membranes of the heart cells. Furthermore, a utilized as a model for the study of cardiac arrhythmogenic prospective randomized clinical trial (7) showed that, among factors. The myocytes respond to the toxic effects of a potent men who had recently suffered a myocardial infarction, those cardiac glycoside, ouabain at 0.1 mM, by an increase in their that were advised to eat fish two or three times a week had spontaneous beating rate and a reduction in amplitude of a 29% reduction in fatal myocardial infarctions over a sub- contractions resulting within minutes in a lethal state of sequent 2-year period compared to those patients not given contracture. Incubating the isolated myocytes for 3-S5 days in such advice. There was, however, no significant difference in culture medium enriched with 5 ,IM arachidonic acid [20:4 cardiac events; those eating fish just did not die as frequently (n-6)] had no effect on the development of lethal contracture of their myocardial infarctions.
    [Show full text]
  • Dennis G. Maki, M.D. June 2015
    Dennis G. Maki, M.D. June 2015 Dr. Maki is the Ovid O. Meyer Professor of Medicine in the Divisions of Infectious Diseases and Pulmonary-Critical Care Medicine at the University of Wisconsin School of Medicine and Public Health in Madison, Wisconsin, attending physician in the UWHC Center for Trauma and Life Support and eICU, and former Head of the Division of Infectious Diseases 1979 through 2007. Dr Maki, a 1967 graduate of the University of Wisconsin School of Medicine and Public Health, did his internal medicine residency training on the Harvard Medical Service of the Boston City Hospital, where he was the Chief Resident, and the Massachusetts General Hospital, where he also did his fellowship in infectious diseases, and during this period spent two years as an Epidemic Intelligence Service Officer with the Centers for Disease Control and Prevention. An infectious disease consultant, critical care physician and epidemiologist, he has devoted his research career to the prevention of nosocomial infections and management of life-threatening infections, and has published more than 350 original papers, editorials, chapters and reviews and 700 abstracts of research presented at national or international scientific meetings; his publications have been cited by other researchers more than 16,000 times and provide much of the scientific underpinning for the “bundle” of measures currently employed for prevention of line sepsis in hospitals worldwide. A past consultant to the CDC, NIH, FDA, HHS, GAO and the UK NHS, he is former President of the Society for Healthcare Epidemiology of America and Councillor of the Infectious Diseases Society of America.
    [Show full text]
  • Rush Vs Cobbett the PHAROS of Alpha Omega Alpha Honor Medical Society Autumn 2014
    Alpha Omega Alpha Honor Medical Society Autumn 2014 Rush vs Cobbett THE PHAROS of Alpha Omega Alpha honor medical society Autumn 2014 “Be Worthy to Serve the Suffering” Alpha Omega Alpha Honor Medical Society Founded by William W. Root in 1902 Officers and Directors at Large Editor Richard L. Byyny, MD John Tooker, MD, MBA President Philadelphia, Pennsylvania Editor Emeritus (in memoriam) Robert J. Glaser, MD C. Bruce Alexander, MD Immediate Past President Associate Editor and Helen H. Glaser, MD Birmingham, Alabama Managing Editor Douglas S. Paauw, MD (in memoriam) President-Elect Seattle, Washington Managing Editor Debbie Lancaster Joseph W. Stubbs, MD Secretary-Treasurer Art Director and Illustrator Albany, Georgia Robert G. Atnip, MD Designer Erica Aitken Hershey, Pennsylvania Eve J. Higginbotham, SM, MD Editorial Board Philadelphia, Pennsylvania Richard B. Gunderman, MD, PhD Indianapolis, Indiana Jeremiah A. Barondess, MD Faith T. Fitzgerald, MD Stephen J. McPhee, MD Sheryl Pfeil, MD New York, New York Sacramento, California San Francisco, California Columbus, Ohio David A. Bennahum, MD Daniel Foster, MD Janice Townley Moore Albuquerque, New Mexico Dallas, Texas Young Harris, Georgia Alan G. Robinson, MD John A. Benson, Jr., MD James G. Gamble, MD, PhD Francis A. Neelon, MD Los Angeles, California Portland, Oregon Stanford, California Durham, North Carolina Wiley Souba, MD, DSc, MBA Richard Bronson, MD Dean G. Gianakos, MD William M. Rogoway, MD Hanover, New Hampshire Stony Brook, New York Lynchburg, Virginia Stanford, California Steven A. Wartman, MD, PhD John C.M. Brust, MD Jean D. Gray, MD Shaun V. Ruddy, MD Washington, DC New York, New York Halifax, Nova Scotia Richmond, Virginia Charles S.
    [Show full text]
  • Department of Medicine Report
    Massachusetts General Hospital Department of Medicine A Community for Care Contents le of Tab A Letter from Dr. Armstrong 3 Department of Medicine by the Numbers 5 Organization 2015 6 Division Reports Cardiology Division 7 Endocrine Division 9 Gastroenterology Division 12 Division of General Internal Medicine 14 Hematology & Oncology Division 17 Infectious Diseases Division 19 Nephrology Division 21 Palliative Care Division 23 Division of Pulmonary & Critical Care Medicine 25 Division of Rheumatology, Allergy & Immunology 28 In Memoriam 31 Kenneth D. Bloch, MD 31 Stephen M. Krane, MD 33 Kenneth L. Minaker, MD 35 Notable Publications 36 2014-2015 Residents & Incoming Interns 40 Graduating Fellows 44 2 A Letter from Dr. m, Arms trong I am delighted to share this report of the activities of the Department of Medicine at the Massachusetts General Hospital with you. There is much to celebrate in this report. The residency and fellowship programs are thriving. We are fortunate to attract a diverse group of outstanding young physicians who are dedicated to improving health and health care across the world. The clinical training on our medical services is unparalleled and the level of teamwork, dedication, and critical thinking upholds the standard that has created academic leaders for generations. Our medical services are busier than ever. Patients come to us in part for the remarkable innovations in treatment that are widespread across our services, but, perhaps even more importantly, because of the unsurpassed dedication and compassion that our medical staff provides. Our activities in community health continue to grow, both deepening our commitment to the impact of the MGH community health centers in Charlestown, Chelsea, Everett and Revere, and widening our scope to create new partnerships across the city and the nation.
    [Show full text]
  • The Mechanism of the Osmotic Adjustment of Body Cells As Determined in VIVO by the VOLUME of DISTRIBUTION of a LARGE WATER LOAD
    The Mechanism of the Osmotic Adjustment of Body Cells as Determined IN VIVO BY THE VOLUME OF DISTRIBUTION OF A LARGE WATER LOAD Alexander Leaf, … , Oliver Wrong, Elbert P. Tuttle Jr. J Clin Invest. 1954;33(9):1261-1268. https://doi.org/10.1172/JCI103001. Research Article Find the latest version: https://jci.me/103001/pdf THE MECHANISM OF THE OSMOTIC ADJUSTMENT OF BODY CELLS AS DETERMINED IN VIVO BY THE VOLUME OF DISTRIBUTION OF A LARGE WATER LOAD' By ALEXANDER LEAF,2 JACQUES Y. CHATILLON, OLIVER WRONG, AND ELBERT P. TUTTLE, Ja.8 (From the Departments of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.) (Submitted for publication April 5, 1954; accepted May 14, 1954) Since permeability of cell membranes to water tained. A water load of 100 ml. per kilogram of body has been clearly demonstrated, there are several weight was then administered intravenously at a rate of of cells to dilution approximately 20 ml. per minute. The water load was theoretically possible responses given as a 23h per cent solution of dextrose, or dextrose of the extracellular fluid. Osmotic equilibrium and fructose. Blood samples were obtained following the might result from net movement of water into cells infusion at intervals of three to sixty minutes for five in response to extracellular dilution. On the other or six hours in three experiments. In the other experi- hand, net movement of water into cells might be ments blood samples were taken 4 to 6 hours after the infusion was completed. Some of the dogs received 0.3 averted by: 1) active transport of water out of mgm.
    [Show full text]