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The Member Magazine of the American Society for Biochemistry and Molecular Biology CONTENTS
Vol. 13 / No. 11 / December 2014 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY CONTENTS NEWS FEATURES PERSPECTIVES 2 12 22 PRESIDENT’S MESSAGE GOING GLOBAL WITH GENOMICS EDUCATION Time machine Using active-learning approaches 18 in a lecture hall 4 ‘SCIENCE AND ART MIX SO NEWS FROM THE HILL BEAUTIFULLY TOGETHER’ 24 The policy year in review MINORITY AFFAIRS 20 Like water in a desert 5 PUT A SMILE AROUND YOUR NECK MEMBER UPDATE 26 18 OUTREACH 6 Science to a beat JOURNAL NEWS 6 Protein, you can’t hide anymore! 30 7 Englund writes about his ‘passion for PROFESSIONAL DEVELOPMENT parasites’ How to write a teaching philosophy statement 7 How enzymes came to be when you don’t have a lot of classroom 8 Metalloproteins and their metals experience (or even if you do) 9 Investigating the link between noncoding RNAs and alcoholic liver disease 32 10 Niacin and triglycerides OPEN CHANNELS 32 Mugs for scientists 11 33 The giving list: supporting science with NIH UPDATE 20 annual donations Money, sex and cell tracking 32 6 12 26 Researchers at the Smithsonian National Museum of Natural History want to advance the genomics of as many life forms on Earth as possible. But first they need to figure out the small details that will make or break the effort. Image courtesy of James Di Loreto, Smithsonian DECEMBER 2014 ASBMB TODAY 1 PRESIDENT’S MESSAGE ing the Clock gene, he quickly recog- relative to wild-type strains when In a spectacular, two-page paper nized that it encoded a transcription grown under a 12-hour-to-12-hour published in 2005, Kondo and col- THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY factor – it had a distinct bHLH DNA light-to-dark cycle. -
Speech Communication: 1974
DOCUMENT RESUME ED 102 624 CS 500 992 AUTHOR Kennicott, Patrick C., Ed. TITLE Bibliographic Annual in Speech Communication: 1974. Volume 5. INSTITUTION Speech Communication Association, New York, N.Y. PUB DATE 74 ROTE 307p.; For related documents see CS 500 993-997 AVAILABLE FROM Speech Communication Association, Statler Hilton Hotel, New York, New York 10001 ($8.00 member, $9.00 nonmember) EDRS PRICE MF-$0.76HC-$15.86 PLUS POSTAGE DESCRIPTORS *Annotated Bibliographies; Bibliographies; *Communication (Thought Transfer); Doctoral Theses; *Educational Research; Higher Education; *Sass Media; Research Tools; *Speech; Theater Arts ABSTRACT This annotated bibliography is an annual volume devoted to maintaining a record of graduate work in speech communication, providing abstracts of doctoral dissertations, and making subject area bibliographies available. The contents of this volume include "Studies in Sass Communication: A Selected Bibliography, 1973" by Roland C. Johnson and Kenneth J. Ksobiech; "Behavioral Studies in Communication, 1973: A Selected Bibliography" by 1aomas N. Steinfatt; "A Selected Bibliography of Rhetorical Studies, 1973" by Michael C. Leff; "A Selected Bibliography of Public Address, 1973w by Harold Mixon; "Bibliography of Studies iv. Oral Interpretation, 1973" by James We Carlsen; "A Bibliography of Theatrical Craftsmanship, 1973" by Christian Moe and Jay E. Raphael; "Abstracts of Doctoral Dissertations in the Field of Speech Communication, 1973" by Cal H. Logue; and "Graduate Theses and Dissertations in the Field of Speech Communication, 1973." Also included is an "Index to Academic Departments Reporting Masters Theses and Doctoral Dissertations," by Flora Lisa Miller. UM) U.S. DIIIPARTMINT Of HEALTH. IP 12 EDUCATION I WELFARE NATIONAL INSTITUTE OF EDUCATION THIS DOCUMENT HAS BEENREPRO DUCED EXACTLY AS RECEIVEDFROM THE PERSON OR ORGt.NIZATION ORIGIN 11111M111M1111. -
Board of Trustees Meeting Tuesday, November 18, 2014, 7:00 Pm Agenda
1300 Saint Germain St. W Saint Cloud, Minnesota 56301 Tel. 320.650.2500 Fax 320.650.2501 Board of Trustees Meeting Tuesday, November 18, 2014, 7:00 p.m. Agenda Public Open Forum—Total time: 10 minutes, each person limited to two minutes, speakers must address library related topics not already on the agenda, board members will not interact with public speaker (concerns are referred to management for follow-up), and all parties are expected to display appropriate behavior. 1. Call to Order 2. Adoption/Amendment of Agenda 3. Approval of Minutes 3.1 September 16, 2014, Board Meeting 3.2 October 21, 2014, Board Special Meeting 4. Public Open Forum 5. Financials 5.1 Bills (emailed) and Addendum (on table) (Requested action – Approve) 5.2 Financial Reports (emailed) (Requested action – Accept) 6. Consent Agenda 6.1 CMLE Appointments – Joanne Kudrna and Cecilia Dwyer 6.2 Other 7. Communications 8. Staff Reports 8.1 Interim Executive Director’s Report 8.2 Management Reports 8.3 Building Reports 8.4 Statistics 8.5 Summer Reading Program Statistics 8.6 Library Impact Report 8.7 Fund Development Report 8.8 Staff Recognition Report 9. Committee Reports 9.1 Personnel Committee (verbal) (Requested action – Approve) 9.2 Other 10. Unfinished Business 10.1 Executive Director Search Consultant Selection (Requested action – Approve) 10.2 2015 Budget Ratification (Requested action – Approve) 10.3 Other 11. New Business 11.1 Arts & Cultural Heritage Amendment FY2014 Final Report (Requested action – Approve) 11.2 Storage Array Capital Expenditure Request (Requested action – Approve) 1300 Saint Germain St. W Saint Cloud, Minnesota 56301 Tel. -
UCLA UCLA Electronic Theses and Dissertations
UCLA UCLA Electronic Theses and Dissertations Title Discovery of a Novel Mevalonate Pathway and its Potential to Produce Biofuels Permalink https://escholarship.org/uc/item/81s1f174 Author Vinokur, Jeffrey Vinokur Publication Date 2017 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA Los Angeles Discovery of a Novel Mevalonate Pathway and its Potential to Produce Biofuels A dissertation submitted in the partial satisfaction of the requirements for the degree Doctor of Philosophy in Biochemistry, Molecular and Structural Biology by Jeffrey Michael Vinokur 2017 © Copyright by Jeffrey Michael Vinokur 2017 ABSTRACT OF THE DISSERTATION Discovery of a Novel Mevalonate Pathway and its Potential to Produce Biofuels by Jeffrey Michael Vinokur Doctor of Philosophy in Biochemistry, Molecular and Structural Biology University of California, Los Angeles, 2017 Professor James U. Bowie, Chair The mevalonate pathway is present in eukaryotes, archaea, and some bacteria, where it produces the building blocks used to make cholesterol, vitamin A, natural rubber, and over 25,000 other biomolecules collectively called isoprenoids. Here we report the discovery of a novel mevalonate pathway in archaea. We describe the identification and characterization of three new enzymes, two new metabolites, a novel structure, and a new mechanism. We also show that the new pathway is unique to extreme acidophiles that grow below pH 2. We attempt to re-design three mevalonate pathway enzymes (mevalonate 3-kinase, mevalonate 5- phosphate decarboxylase, and mevalonate 5-pyrophosphate decarboxylase) to produce isoprenol through the decarboxylation of mevalonate. Isoprenol is a 5-carbon alcohol that has a higher energy density than ethanol. -
UCLA Chemistry & Biochemistry Orientation Handbook
Department of Chemistry & Biochemistry UCLA Chemistry, Biochemistry & Chemistry Material Science New & Transfer Student Handbook 2014-2015 Table of Contents Welcome Newsletter ............................................................................................................................................... 1 Introduction ............................................................................................................................................................ 3 Professors & Advisors ........................................................................................................................................... 4 Chemistry & Biochemistry Undergraduate Office.............................................................................................. 6 Majors in Chemistry & Biochemistry .................................................................................................................. 7 Biochemistry ........................................................................................................................................................... 8 Chemistry .............................................................................................................................................................. 11 Physical Chemistry Concentration ..................................................................................................................... 13 Chemistry-Materials Science .............................................................................................................................. -
Calsaround Theworld
Wisconsin’s Magazine for the Life Sciences • Summer 2011 grow food & agriculture • environment • energy • health CALS around theWorld Changing lives through global engagement Students work with Ugandan villages on safe drinking water and other crucial health needs College of Agricultural & Life Sciences UNIVERSITY OF WISCONSIN-MADISON Desert spuDs • rebuilDing kosovo Dairy • brewing guru on campus Getting to know you: CALS nutritional sciences student Rebecca Residorf making friends in rural Uganda. This photo and many others in this issue were taken by CALS biochemistry student Christopher Pearce, a fellow Uganda study abroad participant. Volume 4, Issue 3 • Summer 2011 grow Wisconsin’s Magazine for the Life Sciences 12 CALS AROUND THE WORLD: A Special Feature The boundaries of the university are the boundaries of the world—and CALS is in the forefront of global activity. In this feature package we explore how international work helps other countries and makes Wisconsin a better place. 13 It Takes a Village: Undergraduates in a CALS study abroad program found a nonprofit serving rural villages in Uganda. By Frank Bures 19 Rebuilding from the Ruins: A phone call to CALS from a concerned Madison businessman leads to a part- nership improving dairy in war-ravaged Kosovo. By Joan Fischer 21 Desert Spuds: The quest to improve potato growth in the arid Middle East leads to cost-saving innovations and closer ties among scientists from nations in conflict. By Joan Fischer 24 Bridging Borders: Wisconsin undergrads curious about migrant workers on local farms get a firsthand view of Mexican life and agriculture. By Masarah Van Eyck 27 Science Ambassadors: A program named after Nobel Laureate Har Gobind Khorana fosters scientific exchange between Wisconsin and India. -
2015–2016 SEASON Caltechlive! Experience Caltech...Live!
REDUCED SHAKESPEARE COMPANY THE COMPLETE HISTORY OF COMEDY (ABRIDGED) GOOD LOVELIES SWINGING HARMONIES AND HILARIOUS TALES MARK O’CONNOR–AN APPALACHIAN CHRISTMAS HOLIDAY MELODIES FROM THE SMOKY MOUNTAINS GARRY KRINSKY TOYING WITH SCIENCE YAMATO THE DRUMMERS OF JAPAN THE HOT SARDINES SPEAKEASY NIGHTS BRADLEY FIELDS–MATHEMAGIC! A MAGIC SHOW CALADH NUA BELOVED MELODIES FROM THE EMERALD ISLE THE INTERGALACTIC NEMESIS: TARGET EARTH A LIVE-ACTION GRAPHIC NOVEL CAPITOL STEPS POLITICAL SATIRE 2015–2016 SEASON Caltechlive! Experience Caltech...live! SATURDAY, OCTOBER 17, 2015/8 PM SATURDAY, DECEMBER 12, 2015/8 PM Reduced Shakespeare Company It’s a show about wit. About quick minds. Mark O’Connor–An Appalachian Christmas With all the hustle and bustle associated with The Complete History of Comedy (abridged) About what makes us laugh. And what’s fair Holiday Melodies from the Smoky Mountains this time of year, it’s a real joy to find some- Get ready for a laugh fest as the Reduced Shake- game for laughter. Grammy-winning violinist/fiddler Mark O’Connor thing so simple and pure as this holiday speare Company presents their clever take on —Cincinnati Enquirer transports audiences to the rolling hills and wooded offering from Mark O’Connor. comedy through the ages, from Aristophanes, hollows of Appalachia with playful and joyous songs —The Daily Local News, PA $38, $33, $28 / $10 YOUTH Shakespeare, and Moliere to Vaudeville, Charlie and music of the season. Merging folk, country, jazz, $45, $40, $35 / $10 YOUTH Chaplin, and The Daily Show. The bad boys of and classical music, O’Connor and friends usher us abridgment leave no joke untold as they deconstruct into the holidays with warmth and elegance. -
Transcriptional Termination by Bacterial RNA Polymerase
GENOME-SCALE STUDIES OF RHO-DEPENDENT TRANSCRIPTION TERMINATION IN ESCHERICHIA COLI by Jason Matthew Peters A dissertation submitted in partial fulfillment of the requirement for the degree of Doctor of Philosophy (Genetics) at the UNIVERSITY OF WISCONSIN – MADISON 2012 Date of final oral examination: 8/10/12 The dissertation is approved by the following members of the Final Oral Committee: Robert Landick, Professor, Biochemistry Gary Roberts, Professor Emeritus, Bacteriology Richard Burgess, Professor Emeritus, Oncology Audrey Gasch, Associate Professor, Genetics Nicole Perna, Associate Professor, Genetics i Genome-scale studies of Rho-dependent transcription termination in Escherichia coli Jason Matthew Peters under the supervision of Professor Robert Landick University of Wisconsin – Madison Rho is a homohexameric ring-shaped protein that translocates nascent RNA through its central cleft in an ATP-dependent manner, then dissociates RNA polymerase (RNAP) from RNA and template DNA. Despite decades of study, little was known about Rho association with transcription elongation complexes (ECs); sites of Rho termination across the E. coli chromosome; and the effects of the elongation factors NusG, NusA, and the nucleoid structuring protein H-NS on Rho termination. I found that Rho and RNAP have very similar distributions on DNA, suggesting that Rho associates with ECs early and throughout the process of transcription elongation. This association allows Rho to quickly respond to termination signals such as those that are unmasked when transcription and translation become uncoupled. Prior to my studies, the sites of Rho termination in E. coli were mostly unknown. I identified Rho-dependent terminators by examining the distribution of RNAP on DNA in Rho-inhibited cells.