Personalised Mesothelioma Treatment Trial Opens in UK
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Risk Factors for Malignant Mesothelioma
cancer.org | 1.800.227.2345 Malignant Mesothelioma Causes, Risk Factors, and Prevention Risk Factors A risk factor is anything that affects your chance of getting a disease such as cancer. Learn more about the risk factors for malignant mesothelioma. ● Risk Factors for Malignant Mesothelioma ● What Causes Malignant Mesothelioma? Prevention There's no way to completely prevent mesothelioma. But there are things you can do that might lower your risk. Learn more. ● Can Malignant Mesothelioma Be Prevented? Risk Factors for Malignant Mesothelioma A risk factor is anything that increases your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed. But having a 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 known risk factor, or even many, does not mean that you will get the disease. And some people who get the disease may have few or no known risk factors. Researchers have found some factors that increase a person’s risk of mesothelioma. Asbestos The main risk factor for pleural mesothelioma is exposure to asbestos. In fact, most cases of pleural mesothelioma have been linked to high levels of asbestos exposure, usually in the workplace. Asbestos is a group of minerals that occur naturally as bundles of tiny fibers. These fibers are found in soil and rocks in many parts of the world. When asbestos fibers in the air are inhaled, they can get into the lungs. Fibers that stay in the lungs can travel to the ends of the small airways and enter the pleural lining of the lung and chest wall. -
Solitary Fibrous Tumor of the Pleura: Histology, CT Scan Images and Review of Literature Over the Last Twenty Years
DOI: 10.26717/BJSTR.2017.01.000150 Flavio Colaut. ISSN: 2574-1241 Biomed J Sci & Tech Res Case Report Open Access Solitary Fibrous Tumor of the Pleura: Histology, CT Scan Images and Review of Literature over the Last Twenty Years Giulia Bora1, Flavio Colaut2*, Gianni Segato3, Luisa Delsedime4 and Alberto Oliaro1 1Department of Thoracic Surgery, University of Turin, Italy 2Department of General Surgery and Thoracic, City Hospital , Montebelluna, (Treviso), Italy 3Department of General Surgery, S. Bortolo City Hospital, Vicenza, Italy 4Department of Pathology, University of Turin, Italy Received: June 14, 2017; Published: June 26, 2017 *Corresponding author: Flavio Colaut, Department of General Surgery, City Hospital Montebelluna, Thoracic City Hospital, via Montegrappa 1, 31044 Montebelluna (Treviso), Italy, Tel: ; Fax: 0499367643; Email: Introduction Literature up to 800 cases [1-3] have been reported, and these in case of recurrence [10,16,17]. In less than 5% of patients with Solitary fibrous tumor of the pleura is a rare neoplasm. In numbers show its rarity, despite of mesotheliomas, the most pleural SFPTs an increase of insulin-like factor II type occur and this causes refractory to therapy hypoglycaemia (Doege-Potter syndrome) similar in both sexes and there no differences in both benign and [10,18,19]. The incidence of Doege-Potter syndrome in SFPT is tumors represented. Males and females are equal distributed asbestos, tobacco or others environmental agents, were found for and the same is true for age. No correlation with exposure to malignantSome patients forms. may also present gynecomastia or galactorrhoea its development. Solitary fibrous tumor of the pleura occurs as localized neoplasms of the pleura and was initially classified as microscope and immunohistochemistry, has been possible [1]. -
Global Mesothelioma Deaths Reported
ResearchResearch Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008 Vanya Delgermaa,a Ken Takahashi,a Eun-Kee Park,a Giang Vinh Le,a Toshiyuki Haraa & Tom Sorahanb Objective To carry out a descriptive analysis of mesothelioma deaths reported worldwide between 1994 and 2008. Methods We extracted data on mesothelioma deaths reported to the World Health Organization mortality database since 1994, when the disease was first recorded. We also sought information from other English-language sources. Crude and age-adjusted mortality rates were calculated and mortality trends were assessed from the annual percentage change in the age-adjusted mortality rate. Findings In total, 92 253 mesothelioma deaths were reported by 83 countries. Crude and age-adjusted mortality rates were 6.2 and 4.9 per million population, respectively. The age-adjusted mortality rate increased by 5.37% per year and consequently more than doubled during the study period. The mean age at death was 70 years and the male-to-female ratio was 3.6:1. The disease distribution by anatomical site was: pleura, 41.3%; peritoneum, 4.5%; pericardium, 0.3%; and unspecified sites, 43.1%. The geographical distribution of deaths was skewed towards high-income countries: the United States of America reported the highest number, while over 50% of all deaths occurred in Europe. In contrast, less than 12% occurred in middle- and low-income countries. The overall trend in the age- adjusted mortality rate was increasing in Europe and Japan but decreasing in the United States. Conclusion The number of mesothelioma deaths reported and the number of countries reporting deaths increased during the study period, probably due to better disease recognition and an increase in incidence. -
Repetitive Use Injuries
PATIENT HANDOUT Repetitive Use Injuries as assembly-line workers, stock clerks, ware- enjoy doing. Here are six simple hand exercises house workers, transcriptionists and garment that will move your joints, stretch your tendons workers are at risk. Also, people who work as and keep your hands healthy: gardeners, bank tellers, musicians and even athletes should be aware of RSIs. 1. Place both hands in front of you and stretch your fingers out, keeping them up and open DO I HAVE AN RSI? for a few seconds. These injuries are more than just a sore wrist or aching fingers. Overuse and misuse of the 2. Keep both of your hands in front of you and hand can lead to serious injuries. You should curl your fingers and thumb into a ball.H old be aware of the following injuries and take pre- this position a few seconds. ventative measure to avoid them: 3. Put your arms in front of you and lift your Carpal Tunnel Syndrome: This compression right hand so that the palm of your hand of the median nerve through the carpal tunnel, points out and your fingers face up. Using located at the base of the hand, causes numbness your other hand, push the fingers towards e take medicine to improve blood and tingling of the fingers, weakness and pain. your body until you feel a slight stretch. pressure. We try to eat foods that Repeat with the other hand. will decrease our cholesterol. DeQuervain’s Tenosynovitis: This RSI is local- And we exercise to keep our ized to the tendons of the thumb at the level of 4. -
Epidemiology and Clinical Aspects of Malignant Pleural Mesothelioma
cancers Review Epidemiology and Clinical Aspects of Malignant Pleural Mesothelioma Fraser Brims 1,2,3 1 Curtin Medical School, Curtin University, Perth, WA 6845, Australia; [email protected] 2 Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia 3 National Centre for Asbestos Related Diseases, Institute for Respiratory Health, Perth, WA 6009, Australia Simple Summary: Mesothelioma is a cancer of the lining of the lungs caused by breathing in asbestos fibres. Asbestos was widely used in industry in the last century in most developed countries and is still present in many older buildings to this day. There is no known safe level of asbestos exposure. Symptoms of mesothelioma can include worsening breathlessness, chest pain and loss of weight. There is no cure, and the treatment of mesothelioma is limited, although there have been some recent improvements in therapy. Survival is very variable although most people live for around one year after diagnosis. Efforts to improve and maintain the quality of life for patients with mesothelioma remain a priority. Abstract: Mesothelioma is a cancer predominantly of the pleural cavity. There is a clear association of exposure to asbestos with a dose dependent risk of mesothelioma. The incidence of mesothelioma in different countries reflect the historical patterns of commercial asbestos utilisation in the last century and predominant occupational exposures mean that mesothelioma is mostly seen in males. Modern imaging techniques and advances in immunohistochemical staining have contributed to an improved diagnosis of mesothelioma. There have also been recent advances in immune checkpoint inhibition, however, mesothelioma remains very challenging to manage, especially Citation: Brims, F. -
Chrysotile Asbestos As a Cause of Mesothelioma: Application of the Hill Causation Model
Commentary Chrysotile Asbestos as a Cause of Mesothelioma: Application of the Hill Causation Model RICHARD A. LEMEN, PHD Chrysotile comprises over 95% of the asbestos used this method, researchers are asked to evaluate nine today. Some have contended that the majority of areas of consideration: strength of association, tempo- asbestos-related diseases have resulted from exposures rality, biologic gradient, consistency, specificity, bio- to the amphiboles. In fact, chrysotile is being touted as logic plausibility, coherence, experimental evidence, the form of asbestos which can be used safely. Causa- and analogy. None of these considerations, in and of tion is a controversial issue for the epidemiologist. How itself, is determinative for establishing a causal rela- much proof is needed before causation can be estab- tionship. As Hill himself noted, “[n]one of my nine lished? This paper examines one proposed model for establishing causation as presented by Sir Austin Brad- view points can bring indisputable evidence for or ford Hill in 1965. Many policymakers have relied upon against the cause and effect hypothesis, and none can this model in forming public health policy as well as be required as a sine qua non.” In the same vein, it is deciding litigation issues. Chrysotile asbestos meets not necessary for all nine considerations to be met Hill’s nine proposed criteria, establishing chrysotile before causation is established. Instead, Hill empha- asbestos as a cause of mesothelioma. Key words: sized that the responsibility for making causal judg- asbestos; chrysotile; amphiboles; causation; mesothe- ments rested with a scientific evaluation of the totality lioma; Hill model. of the data. -
At Home Ergonomics
At Home Ergonomics Andrew Dolhy CPE MFL Occupational Health Centre www.mflohc.mb.ca (204) 949-0811 Safety Program Individual Organizational Flexibility Health Risk Promotion Assessment Andrew Dolhy, CPE Disruption • Telework policies – new ways to work • OHC has – Definitions, Rationale – Telework Program Plan – Equipment and Security – Health and Safety Andrew Dolhy, CPE New Ideas Open Minded yet Critical • Initial work was standing – Hard on the body so sitting • 1960’s – need to get sitting because standing is too hard on the body – Sitting is the new smoking Throw book out the window Key Points It’s the Job and Education/Awareness Wear and Tear – too much / too often Hazards and Risks – cause / aggravate Andrew Dolhy, CPE Andrew Dolhy, CPE Musculoskeletal Injuries! • Common Names • repetitive strain injury (RSI), repetitive motion injury, cumulative trauma disorder (CTD), sprains and strains, overuse injury Work Load > Body Capacity = wear and tear ~ INJURY . Andrew Dolhy, CPE Why Ergonomics is Important in Manitoba WCB MANITOBA CLAIMS, 1997 By DIAGNOSIS (n=389,204 days) Sprains and Strains - 42% RSI’s, CTS - 4% Andrew Dolhy, CPE Signs and Symptoms of a Repetitive Strain Injury Pain or Discomfort Swelling and Inflammation Numbness and Tingling Stiffness or decreased movement Symptoms worsen with time Andrew Dolhy, CPE What’s Missing Neck Tension Shoulder Neck Thoracic Syndrome Outlet Head Syndrome aches Elbow Tendonitis Epicondylitis Bursitis Mechanical Stress Low Wrist Mechanical stress Hand Carpal Tunnel Back Thigh Trigger Finger Syndrome Discs Mechanical Vibration White Tenosynovitis Bones stress Finger Ganglion Muscles Mechanical stress Andrew Dolhy, CPE Stages of Injury • Day to Day Aches and Pains • Hurts for a few days • Interferes with work, other activities • Chronic Pain Andrew Dolhy Specific Limits? • Exactly how much and how often? • Specific number of repetitions? • Threshold Limit Values? Ethics! Andrew Dolhy, CPE Asbestos Quote “We repudiate the term ‘Asbestos Poisoning’. -
Latent Claims – What We Know About Things We Don't Know About
Latent Claims – What we know about things we don’t know about © Latent Claims Working Group 2007 Jefferson Gibbs, Stewart McCarthy Jonathan Perkins, Daniel Smith Introduction and Overview • What are latent claims? • Reserving issues – accounting vs actuarial • Our analysis • Management options • Key conclusions Background • Latent claims working group formed by IAAust Accident Compensation Sub- Committee • Key focus claims other than asbestos • How is the Australian insurance industry addressing latent claims issues? • Paper to be finalised following your input What are latent claims? “what matters to the insurer is the long delay and the fact that the claims were not anticipated “ • Common features: – Long reporting delays since exposure – Admissible claims with no underwriting/pricing – Gradual Exposure – Often no clear Event Date • A full taxonomy is given in the paper What are latent claims? Taxonomy Claim Characteristics Exposure Characteristics Legal Aspects Underwriting Status The Cause Claim Nature Propensity to claim Emerged Substance Disease Low Acts i.e. where underwrting has taken into account Medium Injury Environment Negative impact to individual High Excluded through terms or or by refusing cover Causal Link Es tablis hed Legal Status With Disease Priced - with conditions Un-es tablis hed Established and or stable Illnes s or fatality Also of relevance under casual link As yet unclear Excluded from claims occuring - covered within claims Treatable or not Scientific evidence made Extent of knowledge about the causal link or How long the illnes s las ts potential causal link Medical impact Medical evidence and epidemiology Pending cons ideration Social Norms Whether advocacay and or support groups Legal Interpretation Within Negative Impact exist Case law Property Damage Law and regulation. -
MSU School of Music Health and Safety Document (Available Online At
MSU School of Music Health and Safety Document (available online at http://www.montana.edu/music/health) Introduction The MSU School of Music, as required by the National Association of Schools of Music, is proactive in informing and training anyone who might be physically endangered by practicing, performing, teaching, or listening to music. This training is designed to prevent injuries. Resources Students are encouraged to supplement information obtained in their lessons, seminars, master classes, and guest lectures regarding musicians' health and safety issues by utilizing the resources listed below. The following resources contain best practices related to health and safety in musical settings. These are links to research-based strategies for maintaining personal health and safety within the contexts of practice, performance, teaching, and listening. Protecting Your Hearing Health • NASM-PAMA Student Information Sheet on Noise-Induced Hearing Loss (PDF) • Music Induced Hearing Loss and Hearing Protection, by John F. King, Au.D. • OSHA: Noise/Hearing Conservation • Hearing Loss Decibel Levels • Noises and Hearing Loss Musculoskeletal Health and Injury • The Role of Rest, by Ralph A. Manchester (PDF) • A Painful Melody: Repetitive Strain Injury Among Musicians, by Tamara Mitchell (PDF) • Repetitive Stress and Strain Injuries: Preventive Exercises for the Musician, by Gail A. Shafer-Crane (PDF) • MusiciansHealth.com Psychological Health • MSU Counseling and Psychological Services • Performance Anxiety (WebMD) • Conquering performance anxiety from inside out, by Helen Spielman (PDF) • The Inner Game of Music , by Barry Green and W. Timothy Gallwey • A Saprano on Her Head: Right-Side-Up Reflections on Life and Other Performances , by Eloise Ristad Equipment and Technology Safety • Students working as concert monitors in Reynolds Recital Hall must complete a training session on how to safely move the grand pianos on stage. -
Pleural Localized Malignant Mesothelioma Mimicking a Benign Solitary Fibrous Tumor of the Pleura on Chest Computed Tomography
Case Report pISSN 1738-2637 / eISSN 2288-2928 J Korean Soc Radiol 2017;76(6):429-433 https://doi.org/10.3348/jksr.2017.76.6.429 Pleural Localized Malignant Mesothelioma Mimicking a Benign Solitary Fibrous Tumor of the Pleura on Chest Computed Tomography: A Case Report 흉부 전산화단층촬영에서 양성 고립섬유 종양과 유사한 소견을 보이는 흉막의 국소성 악성 중피종: 증례 보고 Hwi Ryong Park, MD1, Semin Chong, MD1*, Mi Kyung Kim, MD2 Departments of 1Radiology, 2Pathology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea Pleural malignant mesotheliomas arise from mesothelial cells in the pleura. They are characterized as diffuse or localized malignant mesotheliomas (LMM). Diffuse ma- Received June 21, 2016 lignant mesotheliomas spread diffusely along pleural surfaces, while LMM are well- Revised September 20, 2016 Accepted October 18, 2016 circumscribed nodular lesions with no gross or microscopic diffuse pleural spread- *Corresponding author: Semin Chong, MD ing. Therefore, LMM can be radiologically confused with solitary fibrous tumors of Department of Radiology, Chung-Ang University Hospital, the pleura (SFTP), which commonly presents as a solitary, well-demarcated periph- Chung-Ang University College of Medicine, eral mass abutting the pleural surface upon the completion of a computed tomog- 102 Heukseok-ro, Dongjak-gu, Seoul 06973, Korea. raphy (CT). Therefore, this study reports on a 63-year-old female patient with a Tel. 82-2-6299-2646 Fax. 82-2-6299-2017 pathologically-proven LMM of the pleura, mimicking a benign SFTP upon having a E-mail: [email protected] chest CT. Although LMM is extremely rare, FDG PET/CT should be recommended for This is an Open Access article distributed under the terms adequate tumor management in order to avoid misdiagnosing the tumor as a be- of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) nign SFTP when an interfissural or pleural-based mass is seen on the chest CT. -
A Review of Mercury Exposure and Health of Dental Personnel
Accepted Manuscript A review of mercury exposure and health of dental personnel Natasha Nagpal, Dr Silvana S. Bettiol, Amy Isham, Ha Hoang, Leonard A. Crocombe PII: S2093-7911(16)30033-6 DOI: 10.1016/j.shaw.2016.05.007 Reference: SHAW 178 To appear in: Safety and Health at Work Received Date: 24 February 2016 Revised Date: 18 May 2016 Accepted Date: 30 May 2016 Please cite this article as: Nagpal N, Bettiol SS, Isham A, Hoang H, Crocombe LA, A review of mercury exposure and health of dental personnel, Safety and Health at Work (2016), doi: 10.1016/ j.shaw.2016.05.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT Title A review of mercury exposure and health of dental personnel Authors Natasha NAGPAL, Oxford Brookes University, School of Psychology, Social Work and Public Health, Oxford UK Silvana S. BETTIOL, School of Medicine, University of Tasmania, Hobart, Tasmania, Hobart, Australia Amy ISHAM, University Department of Rural Health, University of Tasmania, Tasmania, Hobart, Australia Ha HOANG, University Department of Rural Health, University of Tasmania, Tasmania, Hobart, Australia Leonard A. CROCOMBE, University Department of Rural Health, University of Tasmania, Tasmania, Hobart, Australia Corresponding Author Dr Silvana S Bettiol PhD MANUSCRIPT School of Medicine, University of Tasmania, 17 Liverpool Street Hobart, Tasmania, 7000, Australia Phone: +61 3 62264826 Email: [email protected] Running title Mercury exposure and health of dental personnel ACCEPTED ACCEPTED MANUSCRIPT Abstract Considerable effort has been made to address the issue of occupational health and environmental exposure to mercury. -
Elim Ination of Asbestos- Related Diseases
DRAFT Elim ination of asbestos- related diseases POLICY PAPER The term "asbestos" designates a group of naturally occurring fibrous serpentine or amphibole minerals that have extraordinary tensile strength, conduct heat poorly and are relatively resistant to chemical attack. The principal varieties of asbestos are chrysotile, a serpentine material, and crocidolite, amosite, anthophylite, tremolite and actinolite, all of which are amphiboles (1). It causes asbestosis - a non-malignant fibrosis of the lungs - as well as lung cancer, mesothelioma and other cancers. (2) Exposures to asbestos and its im pact on public health are substantial Exposure to asbestos occurs primarily through inhalation of fibres from the air in the working environment, ambient air in contaminated communities and indoor air in housing and buildings containing asbestos. The highest levels of exposure occur during spraying of asbestos, repackaging of asbestos containers, mixing with other raw material and dry cutting of asbestos-containing products with abrasive tools. Currently about 124 million people in the world are exposed to asbestos1. Each year about 89,000 people die from asbestos-related diseases: lung cancer - 39,0002, mesothelioma - 43,000 (4) and asbestosis - 7,000 (5). These diseases have high fatality rates and do not respond well to medical treatment. Because of the long latency periods attached to these diseases, stopping the use of asbestos will only result in a decrease in the number of asbestos-related deaths after a number of decades. Therefore, even in countries that banned the use of asbestos in the 1990s, the toll of asbestos-related diseases will continue to increase for the interim.