Index

ACTH 103, 152 Clomiphene 159-170 Actinomycin D 92 Contraceptive pills 154 Aldosterone receptor 61 Cortexolone 151-155 Androgen metabolism 133-144 Corticosterone 104, 151, 155 receptor 60 Cortisol 89 sensitive neurones 68 Cortisone 104 Androstanediol 13 3 Cortivazol 151-155 Androstanetriol 141 Crosslinking agents 31 Anterior pituitary 13 7 Cycle-oxygenase 101 Anti-inflammatory action of steroids 85-95 Cyproterone acetate 155 Anti-oestrogenic activity 55, 159-171 Cytosol 15 Anti-oestrophilin antibodies 1-14 Cytotoxicity 76 Antiphlogistic drugs 98 Antitumour activity Danazol 154 progestins 53 Demegestone 14 7-155 Antiuterotrophic activity Desoximetasone 151-155 anti-oestrogens 163 Dexamethasone 89, 91, 102-108,147, 151 progestins 153 Dihydrotestosterone 13 3-142 Arachidonate oxidation 97-114 Dirnethyladipirnate 3 2 Aspirin 98 Dirnethyldithiobispropionimidate 32 Aspirin-like drugs 98 Dirnethylsuberimidate 32 Dithio bis 3 2 Betamethasone 1 04 Blood 59 Brain 59-74 Enclomiphene 159 BW755C 99 Endometrium 49-57 Endometrosis 154 Carcinoma 50 Endoplasmic reticulum (microsomal Castration 136 fraction) 122 Catechol oestrogens 118 End-organ metabolism of oestrogens Catechol-0-methyltransferase' 118, 126 115-130 Chlormadinone acetate 14 7-155 Cholinergic nerves 6 2 Feminine sexual behaviour 67 CI628 162-170 Fludrocortisone 102-105 I 78 Index

Gestrinone 14 7-155 Nafoxidine 162-170 Glucocorticoids Neoplasia 9, 49 antiexudative action 89 Nervous system 59-74 anti-inflammatory action 85-95 Neurotransmitters 64 cytotoxicity 76 Niflumic acid 102 effect on immune system 75-80 Noradrenaline 12 7 induction of neuronal phosphoprotein 66 Norgestrienone 147-155 tyrosine aminotransferase 151 Norgestrol 60, 14 7 influence on lymphocyte activation 78 Normetanephrine 127 prostaglandin biosynthesis 101 interaction with bradykinin Oestradiol phospholipase A1 101 prostaglandins 88, 101 activation of sexual behaviour 6 7 Glutathione 117 effect on muscarinic receptors 65 Gonadotropins 135, 140, 159 receptor binding 162 Guinea pig lung 103 transcription 168 vaginal cyclicity 124 Oestradiol-1713 oxidoreductase 117 H-1285 162-170 Oestriol 117 Hydrocortisone 88, 102, 111 Oestrone 116 Hydroxytamoxifen 25 Oestrogen 2-Hydroxyoestradiol 124, 127 biosynthesis in target tissues 116 4 -Hydroxyoestradiol 128 carcinogenicity 49-57 2-Hydroxyoestrene 117, 124 catechol oestrogens 118 3j3-Hydroxysteroid dehydrogenase 134 effect on neurite growth 6 7 Hyperoestrogenism 51 end-organ metabolism 115-13 2 Hypophysis 68 receptor 60 Hypothalamus 64 structure-function relationships 123 toxicity ICI-79280 162-170 Oestrophilin 9 Immune system 75-84 Oviduct 16 Indomethacin 102 Inflammation 97 Phospholipase A, 101 lnterleukins 79 Phosphoprotein 66 Pituitary, anterior 136 Kinetics of progesterone receptor 18 Pituitary inhibition 154, 159 Plasminogen activator 16 9 Pregnanes 145-155 Leukotrienes 88, 100 Progesterone Lipomodulin 112 activation of sexual behaviour 6 7 Lung 103 LY-117018 160-170 affinity for androgen receptor 155 Lymphocyte activation 78 effect on endometrial neoplasia 49 induction of tyrosine aminotransferase Lymphocytes 75 Lynestrenol 154 151 receptor 15-28, 29-4 7 Progestins 51 Macrophages 75 androgenic activity 4 9 Meclofenamic acid 102 anti-oestrogeilic activity 55 Medroxyprogesterone acetate 14 7-155 anti-uterotrophic activity 153 Mefenamic acid 102 effect on endometrial neoplasia 49-57 2-Methoxyoestrone 118 pituitary inhibition 153 Methyl-4-mercaptobutyrimidate 32 progestational activity 149 Metribolone 14 7-155 receptor 60 Mineralocorticoid receptor 60 Prolactin 13 9 Molybdate 20 Promegestone 14 7-155 Monoclonal antibodies 5 Prostaglandin biosynthesis 86, 101 Monohydroxytamoxifen 162-170 Prostate 136, 138, 149 Muscarinic receptors 65 Prostatic hypertrophy 154 Index 179 Receptors Spironolactone 6 0 aldosterone 61 Steroid hormones androgen 60, 155 agonists and antagonists 145-158 corticosteroid 60 influence on nervous system 59-74 dihydroxytestosterone 61 inhibition of arachidonate oxidation glucocorticoid 60, 85-95 97-114 mineralocorticoid 6 0 Structure-function relationships of muscarinic 60 oestrogens 123 neurotransmitter 64 Synapse formation 67 oestradiol 61 oestrogen 15-28, 60, 162, 165 Tamoxifen 25, 159-170 progesterone 15-28, 29-4 7 Testosterone 62, 64, 133-140, 155 progestin 60 Toxicity of oestrogens 127 serotonin 66 Transcription 168 RU-22779 147-155 Trenbolone 14 7-155 RU-23747 147-155 Triamcinolone acetonide 102 RU-25051 14 7-155 Trioxifene 164-170 RU-25053 147-155 Tumour RU-25055 14 7-155 breast 9 RU-2999 14 7-155 endometrium 49-57 RU-3163 14 7-155 Tyrosine-aminotransferase 14 9

Salicylate 99 Uterotrophic activity Seminal vesicles 13 9 anti-oestrogens 163 Sex hormones Uterus 15 action on immune system 81 effect on endometrial neoplasia 49-57 Zuclomiphene 159