Corneal Dystrophies

1 Corneal Dystrophies

How many categories of corneal dystrophies are listed in the Cornea book? 2 Corneal Dystrophies

How many categories of corneal dystrophies are listed in the Cornea book? Four 3 Corneal Dystrophies

What are the four categories of corneal dystrophies?

? 4 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What are the four categories of corneal dystrophies?

Stromal Dystrophies

Endothelial Dystrophies 5 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What are the four categories of corneal dystrophies?

Stromal Dystrophies Flip back and forth between those first two slides until you have all four categories on lock!

Endothelial Dystrophies 6 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) ? 2) ? What are the six 3) ? epithelial/subepithelial 4) ? corneal dystrophies? 5) ? 6) ?

Epithelial-Stromal TGFBI Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 7 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy What are the six 3) Lisch epithelial corneal dystrophy epithelial/subepithelial 4) Gelatinous droplike corneal dystrophy corneal dystrophies? 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 8 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 9 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy But make sure you know these four! 2) Meesmann epithelial corneal dystrophy They’re blanked out on the next slide so 3) Lisch epithelial corneal dystrophy you can flip back and forth between that 4) Gelatinous droplike corneal dystrophy one and this one until you’ve got ‘em 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 10 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) ? But make sure you know these four! 2) ? They’re blanked out on the next slide so 3) ? you can flip back and forth between that 4) ? one and this one until you’ve got ‘em 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 11 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context?

Stromal Dystrophies

Endothelial Dystrophies 12 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

Stromal Dystrophies

Endothelial Dystrophies 13 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophiesconditions as keratoepithelin dystrophies)

What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions

Endothelial Dystrophies 14 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophiesconditions as keratoepithelin dystrophies)

What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions

Endothelial Dystrophies 15 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophiesconditions as keratoepithelin dystrophies)

What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions

Endothelial Dystrophies 16 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophiesconditions as keratoepithelin dystrophies)

What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions

Endothelial Dystrophies 17 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What does TGFBI stand for in this context? ‘Transforming growth factor beta induced.’ It refers to the gene that codes for the (faulty) protein responsible for the dystrophy.

What is the name of the protein involved in the TGFBI dystrophies? Keratoepithelin (the Cornea book refers in passing to the TGFBI Stromal Dystrophiesconditions as keratoepithelin dystrophies)

What is the clinical hallmark of the keratoepithelin dystrophies? Recurrent epithelial erosions The Cornea book considered this factoid important enough to make it one of three ‘Highlights’ for the Dystrophy chapter—take note of it!

Endothelial Dystrophies 18 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) ? 2) ? What are the six 3) ? epithelial-stromal TGFBI 4) ? corneal dystrophies? 5) ? 6) ?

Stromal Dystrophies

Endothelial Dystrophies 19 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy What are the six 3) Lattice, type 1 epithelial-stromal TGFBI 4) Lattice, variant types (III, IIIA, I/IIIA, IV) corneal dystrophies? 5) Granular type 1 6) Granular type 2

Stromal Dystrophies

Endothelial Dystrophies 20 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy 4) Gelatinous droplike corneal dystrophy 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy How do you pronounce this? Epithelial-Stromal TGFBI Dystrophies RICE BOO-kler 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 How do you pronounce this? 6) Granular type 2 TEAL BEN-key

Stromal Dystrophies

Endothelial Dystrophies 21 Corneal Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 22 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 What is the histologic4) Lattice, hallmark variant types of Reis-Bückler (III, IIIA, I/IIIA, andIV) Thiel-Behnke? Disruption/fragmentation5) Granular type of Bowman’s 1 layer 6) Granular type 2

Stromal Dystrophies

Endothelial Dystrophies 23 Corneal Dystrophies

Stromal Dystrophies

Endothelial Dystrophies 24 Corneal Dystrophies

TheStromal corneal-dystrophy Dystrophies section of the Cornea book underwent a major revision recently. In what ‘category of corneal dystrophy’ were Reis-Bückler and Thiel-Behnke in previous editions? The ’Corneal Dystrophies of Bowmans’

Endothelial Dystrophies 25 Corneal Dystrophies

Endothelial Dystrophies 26 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy These two primarily involve 2) Thiel-Behnke corneal dystrophy Bowman’s membrane 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) There are two ‘lattice’ sets 5) Granular type 1 Two are ‘granular’ forms 6) Granular type 2

Stromal DystrophiesAs a way to help remember them, think of the TGFBI dystrophies as consisting of three pairs of conditions: Two Bowman’s dystrophies, two lattice dystrophies, and two granular dystrophies

Endothelial Dystrophies 27 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 Remembering the two granular types 6) Granular type 2 is easy—there’s a type 1, and a type 2

Stromal Dystrophies

Endothelial Dystrophies 28 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 For lattice, there’s type 1, and type 4) Lattice, variant types (III, IIIA, I/IIIA, IV) ‘everything else’ (which weirdly does 5) Granular type 1 not include a type 2) 6) Granular type 2

Stromal Dystrophies

Endothelial Dystrophies 29 Corneal Dystrophies

Stromal Dystrophies 1) ? 2) ? 3) ? What are the six non-TGFBI 4) ? stromal dystrophies? 5) ? 6) ?

Endothelial Dystrophies 30 Corneal Dystrophies

Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy What are the six non-TGFBI 4) Fleck corneal dystrophy stromal dystrophies? 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 31 Corneal Dystrophies

Stromal Dystrophies The Cornea book addresses all six of these, 1) Macular corneal dystrophy but Macular is covered in greatest detail 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 32 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy Note that, conveniently, there are 3) Lattice, type 1 six conditions in these categories 4) Lattice, variant types (III, IIIA, I/IIIA, IV) (this will help you remember how 5) Granular type 1 6) Granular type 2 many names you have to come up with for each) Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 33 Corneal Dystrophies

Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 1) ? What are the three 2) ? endothelial dystrophies? 3) ? 34 Corneal Dystrophies

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy What are the three 2) Posterior polymorphous corneal dystrophy endothelial dystrophies? 3) Congenital hereditary endothelial dystrophy 35 Corneal Dystrophies

StromalAll three Dystrophies of these are important, albeit for different reasons. Being both common1) Macularand devastating, corneal dystrophy Fuchs gets the most coverage in the Cornea book. PPMD2)gets Schnyder a fair amountcorneal dystrophy of ink as well. CHED gets less attention, but is 3) Congenital stromal corneal dystrophy important4) Fleck for another corneal dystrophyreason: It is on the DDx for infantile cloudy cornea (it’s the E in5) the Posterior infamous amorphous STUMPED cornealmnemonic). dystrophy See slide-set K9 for further info on this 6)important Pre-Descemet topic. corneal dystrophy

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy 36 Corneal Dystrophies

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy 37 Corneal Dystrophies

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy 38 Corneal Dystrophies

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy 39 Corneal Dystrophies

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy 40 Corneal Dystrophies

Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR 41 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Which is/are inherited X-dominant?

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR 42 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy--X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Which is/are inherited X-dominant?

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR 43 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy --X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 For which is the inheritance 6) Granular type 2 as yet unestablished?

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR 44 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy--unestablished 2) Meesmann epithelial corneal dystrophy 3) Lisch epithelial corneal dystrophy --X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 For which is the inheritance 6) Granular type 2 as yet unestablished?

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy--unestablished 2) Posterior polymorphous corneal dystrophy 3) Congenital hereditary endothelial dystrophy--AR 45 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy--unestablished 2) Meesmann epithelial corneal dystrophy--AD 3) Lisch epithelial corneal dystrophy --X-linked dominant 4) Gelatinous droplike corneal dystrophy--AR 5) Epithelial recurrent erosion dystrophies--AD 6) Subepithelial mucinous corneal dystrophy--AD

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy--AD 2) Thiel-Behnke corneal dystrophy--AD 3) Lattice, type 1--AD 4) Lattice, variant types (III, IIIA, I/IIIA, IV)--AD 5) Granular type 1--AD 6) Granular type 2--AD Takeaway: The most common inheritance pattern is AD Stromal Dystrophies 1) Macular corneal dystrophy--AR 2) Schnyder corneal dystrophy--AD 3) Congenital stromal corneal dystrophy--AD 4) Fleck corneal dystrophy--AD 5) Posterior amorphous corneal dystrophy -AD 6) Pre-Descemet corneal dystrophy--unestablished

Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy--unestablished 2) Posterior polymorphous corneal dystrophy--AD 3) Congenital hereditary endothelial dystrophy--AR 46 Corneal Dystrophies

OK, review time. If you can’t answer every question correctly, you need to spend more time with the slide-set. Get these basics down before tackling the other dystrophy-related slide-sets! 47 Corneal Dystrophies

What are the four categories of corneal dystrophies?

? 48 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies

Epithelial-Stromal TGFBI Dystrophies

What are the four categories of corneal dystrophies?

Stromal Dystrophies

Endothelial Dystrophies 49 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies

Epithelial-Stromal TGFBI Dystrophies

? How many conditions are in each category?

Stromal Dystrophies

Endothelial Dystrophies ? 50 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) 2) 3) ? 4) 5) 6)

Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) ? 4) How many conditions are in 5) each category? 6)

Stromal Dystrophies 1) 2) 3) ? 4) 5) 6)

Endothelial Dystrophies 1) ? 2) 3) 51 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) ? 2) ? What are the four 3) ? epithelial/subepithelial 4) ? corneal dystrophies that 5) must be learned? 6)

Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) 4) 5) 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 52 Corneal Dystrophies

Epithelial and Subepithelial Dystrophies 1) Epithelial basement membrane dystrophy 2) Meesmann epithelial corneal dystrophy What are the four 3) Lisch epithelial corneal dystrophy epithelial/subepithelial 4) Gelatinous droplike corneal dystrophy corneal dystrophies that 5) Epithelial recurrent erosion dystrophies must be learned? 6) Subepithelial mucinous corneal dystrophy

Epithelial-Stromal TGFBI Dystrophies 1) 2) 3) 4) 5) 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 53 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) 5) 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 54 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies 1) 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 55 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) notorious for causing… 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. They are notorious for causing… 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 56 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) notorious for causing…REEs 2) 3) The Epithelial-Stromal TGFBI dystrophies are also known as the… 4) keratoepithelin dystrophies, named after the (defective) protein 5) coded for by the TGFBI gene. They are notorious for causing… 6) recurrent epithelial erosions (REE). Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 57 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) notorious for causing…REEs two words 2) Two primarily involve Bowman’s membrane 3) 4) There are two ‘lattice’ sets 5) Two are ‘granular’ forms 6)

Stromal Dystrophies The TGFBI dystrophies can be grouped into 1) three pairs of conditions. What is the common 2) element for each pair? 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 58 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) notorious for causing…REEs 2) Two primarily involve Bowman’s membrane 3) 4) There are two ‘lattice’ sets 5) Two are ‘granular’ forms 6)

Stromal Dystrophies The TGFBI dystrophies can be grouped into 1) three pairs of conditions. What is the common 2) element for each pair? 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 59 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) ? notorious for causing…REEs 2) ? Two primarily involve Bowman’s membrane 3) What4) are the two that primarily involve Bowman’s?There are two ‘lattice’ sets 5) Two are ‘granular’ forms 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 60 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) Reis-Bücklers corneal dystrophy notorious for causing…REEs 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) What4) are the two that primarily involve Bowman’s?There are two ‘lattice’ sets 5) Two are ‘granular’ forms 6)

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 61 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) Reis-Bücklers corneal dystrophy notorious for causing…REEs 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) ? 4) ? There are two ‘lattice’ sets 5) Two are ‘granular’ forms What6) are the two Lattice sets?

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 62 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) Reis-Bücklers corneal dystrophy notorious for causing…REEs 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) Lattice, type 1 4) Lattice, type everything else There are two ‘lattice’ sets 5) Two are ‘granular’ forms What6) are the two Lattice sets?

Stromal Dystrophies 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 63 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) Reis-Bücklers corneal dystrophy notorious for causing…REEs 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) Lattice, type 1 4) Lattice, type everything else There are two ‘lattice’ sets 5) ? Two are ‘granular’ forms 6) ?

StromalWhat Dystrophies are the two Granular forms? 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 64 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies aka the… keratoepithelin dystrophies, 1) Reis-Bücklers corneal dystrophy notorious for causing…REEs 2) Thiel-Behnke corneal dystrophy Two primarily involve Bowman’s membrane 3) Lattice, type 1 4) Lattice, type everything else There are two ‘lattice’ sets 5) Granular type 1 Two are ‘granular’ forms 6) Granular type 2

StromalWhat Dystrophies are the two Granular forms? 1) 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 65 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2

Stromal Dystrophies Which of the stromal dystrophies is ‘first among 1) ? equals’ with respect to importance? 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 66 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2

Stromal Dystrophies Which of the stromal dystrophies is ‘first among 1) Macular equals’ with respect to importance? 2) 3) 4) 5) 6)

Endothelial Dystrophies 1) 2) 3) 67 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2

Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy (Here’s the rest of the ‘stromal crew’) 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy

Endothelial Dystrophies 1) 2) 3) 68 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2

Stromal Dystrophies This endothelial dystrophy is 1) Macular corneal dystrophy common and often devastating: 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy This one is less common, less 4) Fleck corneal dystrophy devastating: 5) Posterior amorphous corneal dystrophy This one is quite uncommon, but is 6) Pre-Descemet corneal dystrophy important because of its place on the STUMPED mnemonic for infantile Endothelial Dystrophies cloudy cornea: 1) ? 2) 3) 69 Corneal Dystrophies

Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, type everything else 5) Granular type 1 6) Granular type 2