Bloodborne Pathogens Training
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Genetic Engineering and Sustainable Crop Disease Management: Opportunities for Case-By-Case Decision-Making
sustainability Review Genetic Engineering and Sustainable Crop Disease Management: Opportunities for Case-by-Case Decision-Making Paul Vincelli Department of Plant Pathology, 207 Plant Science Building, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY 40546, USA; [email protected] Academic Editor: Sean Clark Received: 22 March 2016; Accepted: 13 May 2016; Published: 20 May 2016 Abstract: Genetic engineering (GE) offers an expanding array of strategies for enhancing disease resistance of crop plants in sustainable ways, including the potential for reduced pesticide usage. Certain GE applications involve transgenesis, in some cases creating a metabolic pathway novel to the GE crop. In other cases, only cisgenessis is employed. In yet other cases, engineered genetic changes can be so minimal as to be indistinguishable from natural mutations. Thus, GE crops vary substantially and should be evaluated for risks, benefits, and social considerations on a case-by-case basis. Deployment of GE traits should be with an eye towards long-term sustainability; several options are discussed. Selected risks and concerns of GE are also considered, along with genome editing, a technology that greatly expands the capacity of molecular biologists to make more precise and targeted genetic edits. While GE is merely a suite of tools to supplement other breeding techniques, if wisely used, certain GE tools and applications can contribute to sustainability goals. Keywords: biotechnology; GMO (genetically modified organism) 1. Introduction and Background Disease management practices can contribute to sustainability by protecting crop yields, maintaining and improving profitability for crop producers, reducing losses along the distribution chain, and reducing the negative environmental impacts of diseases and their management. -
Body Substance Isolation PERSONAL PROTECTIVE
CACC Standard 6A Body Substance Isolation AND UNIVERSAL PRECAUTIONS TRAINING PERSONAL PROTECTIVE EQUIPMENT • Blocks entry of an organism into the body – Gloves are most common • Make sure all first aid kits contain several pairs of vinyl, laytex, or Nitrile gloves • Protective eyewear, standard surgical masks, and/or respirators may be necessary • Mouth to barrier (breathing masks) are also recommended PERSONAL PROTECTIVE EQUIPMENT (PPE) • No case of disease transmission to a rescuer as a result of performing unprotected CPR in an infected victim has been documented (only 15 cases of infection reported in last 30 years!) . However, mouth to barrier devices are still strongly recommended! 1 CACC Training Aid 39-H-7 Last Modified 10 Oct 07 CACC Standard 6A UNIVERSAL PRECAUTIONS • Individuals infected with Hepatitis B Virus (HBV) or HIV may not show symptoms and may not even know they are infectious. • All human blood and body fluids should be considered infectious, and precautions should be taken to avoid contact. UNIVERSAL PRECAUTIONS • The Body Substance Isolation (BSI) technique assumes that all body fluids are a potential risk. • Follow BSI procedures even when blood and/or body fluids are not visible UNIVERSAL PRECAUTIONS • Wear appropriate PPE, such as gloves • Use absorbent barriers to soak up blood or other infectious materials • Clean the spill area with an appropriate disinfecting solution, such as bleach • Discard contaminated materials in an appropriate waste disposal container 2 CACC Training Aid 39-H-7 Last Modified 10 Oct -
Zoonotic Diseases Fact Sheet
ZOONOTIC DISEASES FACT SHEET s e ion ecie s n t n p is ms n e e s tio s g s m to a a o u t Rang s p t tme to e th n s n m c a s a ra y a re ho Di P Ge Ho T S Incub F T P Brucella (B. Infected animals Skin or mucous membrane High and protracted (extended) fever. 1-15 weeks Most commonly Antibiotic melitensis, B. (swine, cattle, goats, contact with infected Infection affects bone, heart, reported U.S. combination: abortus, B. suis, B. sheep, dogs) animals, their blood, tissue, gallbladder, kidney, spleen, and laboratory-associated streptomycina, Brucellosis* Bacteria canis ) and other body fluids causes highly disseminated lesions bacterial infection in tetracycline, and and abscess man sulfonamides Salmonella (S. Domestic (dogs, cats, Direct contact as well as Mild gastroenteritiis (diarrhea) to high 6 hours to 3 Fatality rate of 5-10% Antibiotic cholera-suis, S. monkeys, rodents, indirect consumption fever, severe headache, and spleen days combination: enteriditis, S. labor-atory rodents, (eggs, food vehicles using enlargement. May lead to focal chloramphenicol, typhymurium, S. rep-tiles [especially eggs, etc.). Human to infection in any organ or tissue of the neomycin, ampicillin Salmonellosis Bacteria typhi) turtles], chickens and human transmission also body) fish) and herd animals possible (cattle, chickens, pigs) All Shigella species Captive non-human Oral-fecal route Ranges from asymptomatic carrier to Varies by Highly infective. Low Intravenous fluids primates severe bacillary dysentery with high species. 16 number of organisms and electrolytes, fevers, weakness, severe abdominal hours to 7 capable of causing Antibiotics: ampicillin, cramps, prostration, edema of the days. -
Program Syllabus Clinical Practice Training Program Academy of Medical & Public Health Services
Program Syllabus Clinical Practice Training Program Academy of Medical & Public Health Services Meetings: Saturdays, 10:00am to 02:00pm 273 Bowery Street, New York, NY 10002 Instructors: Jerald Chandy ([email protected]) Hewett Chiu ([email protected]) Pensri Ho ([email protected]) Marnelli Hamilton ([email protected]) Mon Yuck Yu ([email protected]) Coordinator: Mon Yuck Yu ([email protected]) Welcome to the Clinical Practice Training Program! This course is designed to equip students with the underlying skills to prepare for further and advanced study in the medical and health sciences. Pursuing a career in medicine, allied health professions, and public health is highly rewarding and fulfilling; but involves much time, preparation, hard work, and financial resources. Through lectures, class discussions, community-based fieldwork, and hands-on clinical practice sessions, students will be able to develop a deeper appreciation for the rigor and intensity of studying the medical sciences. In addition, the coursework is developed to inherently integrate public health and clinical research principles into the clinical sciences for students to better understand both theory and practice in healthcare. Program Syllabus | 1 Course Objectives The objectives of the program are to: Provide a well-rounded experience for the student to see how basic science, clinical skills, public health, health policy, and research design works hand-in- hand in the current U.S. healthcare system. Health professions schools often do not provide training in public health and health policy, and we aim to give students valuable insight into how public health frameworks affect clinical decision-making. -
Chapter 2 Disease and Disease Transmission
DISEASE AND DISEASE TRANSMISSION Chapter 2 Disease and disease transmission An enormous variety of organisms exist, including some which can survive and even develop in the body of people or animals. If the organism can cause infection, it is an infectious agent. In this manual infectious agents which cause infection and illness are called pathogens. Diseases caused by pathogens, or the toxins they produce, are communicable or infectious diseases (45). In this manual these will be called disease and infection. This chapter presents the transmission cycle of disease with its different elements, and categorises the different infections related to WES. 2.1 Introduction to the transmission cycle of disease To be able to persist or live on, pathogens must be able to leave an infected host, survive transmission in the environment, enter a susceptible person or animal, and develop and/or multiply in the newly infected host. The transmission of pathogens from current to future host follows a repeating cycle. This cycle can be simple, with a direct transmission from current to future host, or complex, where transmission occurs through (multiple) intermediate hosts or vectors. This cycle is called the transmission cycle of disease, or transmission cycle. The transmission cycle has different elements: The pathogen: the organism causing the infection The host: the infected person or animal ‘carrying’ the pathogen The exit: the method the pathogen uses to leave the body of the host Transmission: how the pathogen is transferred from host to susceptible person or animal, which can include developmental stages in the environment, in intermediate hosts, or in vectors 7 CONTROLLING AND PREVENTING DISEASE The environment: the environment in which transmission of the pathogen takes place. -
AI 5-8 Communicable Disease Exposure
ADMINISTRATIVE INSTRUCTION Communicable Disease III-5-8 SUBJECT: NUMBER: Exposure Control Plan EFFECTIVE DATE: July 25, 2005 (R) PAGE: 1 of 20 I. Purpose The purpose of the Communicable Disease Exposure Control plan is to protect employees who may be exposed to bloodborne, airborne, and waterborne diseases on the job, and to comply with Cal-OSHA Standard CFR 1910.1030, as part of the City’s Injury and Illness Prevention Program. The intent of the plan is to eliminate or reduce employee occupational exposures to bloodborne, airborne, and waterborne diseases, including the Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), and other bloodborne diseases, as well as Hepatitis A, a non-bloodborne disease; Tetanus, and airborne exposures to tuberculosis. To assure compliance with this plan the City will: 1. Provide protection for employees whose job classifications may frequently or occasionally place them in contact with bloodborne, airborne or waterborne diseases; through universal precautions training, a voluntary vaccination program, engineering controls, work practice controls, housekeeping controls, and use of personal protective equipment where applicable. 2. Provide protection for all employees whose job classifications do not place them in contact with bloodborne, airborne, or waterborne diseases, but may on rare occasion encounter bloodborne, airborne, or waterborne disease exposures while at work, through awareness training, including how to safeguard themselves’ in the event of bloodborne airborne, or waterborne disease exposures while at work or at home. 3. Provide appropriate testing, treatment, follow up, and counseling to employees who have been exposed to bloodborne, airborne, or waterborne diseases while performing their duties for the City. -
Ask a Scientist: How Do People Become Infected with Germs?
One way to think about how living things get sick is to imagine a triangle. The three corners represent the environment... ...the host... All three aspects of this triangle must come ...and the cause of the disease, together for disease to occur. Disease the Agent. agents can be non-infectious or infectious. Non-infectious agents are non-living things that are toxic to the host, like radiation or chemicals... ...while infectious agents are organisms that invade a host to survive. Only infectious agents can spread, or transmit, between hosts. Infectious disease agents, otherwise known as pathogens, A person can become infected with a must infect a host pathogen when in the same environment in order to grow, or as the agent... replicate. Human pathogens, like viruses, bacteria, and parasites, evolved to infect people. Their survival is dependent on quickly invading, making more of themselves, and efficiently transmitting to others. If a pathogen gets past a host’s defenses, it will attempt to infect the host and begin replicating itself. ...and don’t have enough protection in the form The subsequent battle between Many cells will be destroyed as of physical barriers or the germs and the body’s germs kill them through replicating pre-existing immunity. immune system will cause the and as collateral damage from the symptoms of illness. activated immune cells. That’s just how one person gets infected, but how does disease spread? Well, if sick people go around sneezing and coughing without covering their mouth or frequently washing their hands... ...they are actually spreading pathogens all over the environment around them. -
IFIC Book.Indd
Isolation Precautions Chapter 11 Isolation Precautions Gayle Gilmore Key points • Microorganisms causing healthcare-associated infections can be spread from infected or colonised patients to other patients and to staff . Appropriate isolation/precautions can reduce transmission if they are applied properly. • The isolation/precautions policy aims to decrease the spread of infectious agents between staff and patients to such a level that infection or colonisation does not occur. • Isolation/precautions policies have several parts: hand hygiene, protective clothing, single rooms with more or less sophisticated ventilation, and restrictions for movement of patients and staff . • Apply isolation/precautions according to signs and symptoms of the patient; in general, do not wait for laboratory results. 157 IFIC Basic Concepts of Infection Control Introduction 1-3 With the constant emergence of new pathogens, the management of infected patients in the health care sett ing becomes extremely important. The fundamental principles of managing patients with a transmissible infection are: 1. What is to be achieved by using isolation/precautions (IP) 2. Knowledge of the route of transmission of an infectious agent 3. How to reduce risks between patients, and between patients and healthcare workers (HCW) Since hospitals began to segregate patients with potentially transmitt ed pathogens, diff erent types of IP have been recommended. Before 1900, infected patients were segregated in separate wards depending on their diseases. Aft er 1900, the emphasis was on the use of protective barriers for HCWs treating patients with specifi c diseases. Universal Precautions In 1985, the concept of Universal Precautions (UP) was created, primarily due to the acquired immune defi ciency syndrome (AIDS) epidemic. -
Neglected Tropical Diseases in The
Qian et al. Infectious Diseases of Poverty (2019) 8:86 https://doi.org/10.1186/s40249-019-0599-4 SCOPING REVIEW Open Access Neglected tropical diseases in the People’s Republic of China: progress towards elimination Men-Bao Qian1, Jin Chen1, Robert Bergquist2, Zhong-Jie Li3, Shi-Zhu Li1, Ning Xiao1, Jürg Utzinger4,5 and Xiao-Nong Zhou1* Abstract Since the founding of the People’s Republic of China in 1949, considerable progress has been made in the control and elimination of the country’s initial set of 11 neglected tropical diseases. Indeed, elimination as a public health problem has been declared for lymphatic filariasis in 2007 and for trachoma in 2015. The remaining numbers of people affected by soil-transmitted helminth infection, clonorchiasis, taeniasis, and echinococcosis in 2015 were 29.1 million, 6.0 million, 366 200, and 166 100, respectively. In 2017, after more than 60 years of uninterrupted, multifaceted schistosomiasis control, has seen the number of cases dwindling from more than 10 million to 37 600. Meanwhile, about 6000 dengue cases are reported, while the incidence of leishmaniasis, leprosy, and rabies are down at 600 or fewer per year. Sustained social and economic development, going hand-in-hand with improvement of water, sanitation, and hygiene provide the foundation for continued progress, while rigorous surveillance and specific public health responses will consolidate achievements and shape the elimination agenda. Targets for poverty elimination and strategic plans and intervention packages post-2020 are important opportunities for further control and elimination, when remaining challenges call for sustainable efforts. Keywords: Control, Elimination, People's Republic of China, Neglected tropical diseases Multilingual abstracts deprived urban settings [1, 2]. -
Un/Scetdg/20/Inf.41
UN/SCETDG/20/INF.41 COMMITTEE OF EXPERTS ON THE TRANSPORT OF DANGEROUS GOODS AND ON THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS Sub-Committee of Experts on the Transport of Dangerous Goods (Twentieth session, 3-12 December 2001, agenda item 6) Transport of Infectious Substances Transmitted by the World Health Organization Introduction In the past few months the world has changed. Dramatically. It is evident since the events of September 2001, that there must be global preparations for the possibility that people are deliberately harmed with biological agents. Now more than ever, countries need to strengthen their capacity to respond to the consequences of both natural and deliberate incidents of disease outbreak. The World Health Organization (WHO) is ready to assist countries if they should experience the release of a biological agent. Indeed, natural epidemics and those due to the intentional release of biological agents both present in a similar manner. WHO’s “Global Outbreak Alert and Response Network” can quickly detect and respond to outbreaks of communicable disease, whether natural or deliberate. This global network works under the framework of the International Health Regulations, the legal instrument which governs the reporting of epidemic-prone diseases and the application of measures to prevent their spread. In daily contact with its 191 Member States and other partners, WHO systematically collects information, and is committed to its rapid verification and the coordination of the international response, if required. Each year, about 200 outbreaks of potential international importance are actively verified, involving virtually all countries. The confirmation of diagnoses usually requires accurate and urgent analyses, which frequently can only be performed at laboratories that have the technical capacity to detect a wide variety of etiological agents. -
Isolation Precautions
Isolation Precautions Chapter 11 Isolation Precautions Russell N. Olmsted Key Points Microorganisms causing healthcare-associated infections can be spread from infected or colo- nised patients to others, including patients, family, visitors, and healthcare workers. Standard Precautions/Routine Practices and Transmission-based/Additional precautions can re- duce risk and prevent transmission if they are applied properly and consistently. Standard precautions/ Routine Practices are based on the principle that all blood, body fluids, secretions, excretions except sweat, non-intact skin, and mucous membranes may contain trans- missible infectious agents. These precautions apply to care of all patients, regardless of suspect- ed or confirmed infection status, in any setting in which healthcare is delivered. Transmission-based/Additional Precautions are used for patients with documented or suspected infection or colonisation with highly transmissible microorganisms which may not be fully pre- vented by Standard Precautions/Routine Practices. ©International Federation of Infection Control 1 IFIC Basic Concepts of Infection Control, 3rd edition, 2016 Background Transmission of infectious agents (microorganisms) within a healthcare setting requires three elements: a source (or reservoir) of infectious agents, a susceptible host with a portal of entry receptive to the agent, and a mode of transmission for the agent.1-3 One framework for understanding this complex relationship is the chain of infection (See Figure 11.1a), which has six links: the infectious agent, reservoir, portal of exit, mode of transmission, portal of entry, and susceptible host. Breaking any one of the links in the chain will prevent infection from occurring (See Figure 11.1b). Isolation precautions are aimed at interrupting the con- nection – breaking the chain - of these elements to prevent transmission. -
Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I
Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I Working to overcome the global impact of neglected tropical diseases First WHO report on neglected tropical diseases WHO Library Cataloguing-in-Publication Data First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases. 1 Tropical medicine - trends. 2 Endemic diseases. 3 Poverty areas. 4. Parasitic diseases. 5 Developing countries. 6. Annual reports. I. World Health Organization ISBN 978 92 4 1564090 (NLM Classification: WC 680) Working to overcome the global impact of neglected tropical diseases was produced under the overall direction and supervision of Dr Lorenzo Savioli (Director, WHO Department of Control of Neglected Tropical Diseases) and Dr Denis Daumerie (Programme Manager, WHO Department of Control of Neglected Tropical Diseases), with contributions from staff serving in the department. Regional directors and members of their staff provided support and advice. Valuable inputs in the form of contributions, peer reviews and suggestions were received by members of the Strategic and Technical Advisory Group for Neglected Tropical Diseases. The report was edited by Professor David W.T. Crompton, assisted by Mrs Patricia Peters. © World Health Organization 2010 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]).