Mme Fatoumata Kaou SISSOKO Pour Obtenir Le Grade De Docteur En Pharmacie (Diplôme D’État)

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Mme Fatoumata Kaou SISSOKO Pour Obtenir Le Grade De Docteur En Pharmacie (Diplôme D’État) Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Ministère de l’Enseignement Supérieur, République du Mali Et de la Recherche Scientifique Un Peuple – Un But – Une Foi ***************** ***************** FACULTE DE PHARMACIE ****************** Année Universitaire 2011 – 2012 Thèse N°_____/ ETUDE DE LA PHYTOCHIMIE ET DES ACTIVITÉS BIOLOGIQUES DE MUSA ACUMINATA L., DE MANGIFERA INDICA L., DE BOERHAVIA ERECTA L. ET DE ECLIPTA PROSTRATA L. Présentée et soutenue le………… 2012 devant la Faculté de Pharmacie Par Mme Fatoumata Kaou SISSOKO Pour obtenir le grade de Docteur en Pharmacie (diplôme d’état) PRESIDENT : Pr Ibrahim Izetiégouma MAIGA MEMBRE DU JURY : Dr Sékou BAH CODIRECTEUR DE THESE : Dr Seydou Diarra DIRECTEUR DE THESE : Pr Drissa DIALLO Fatoumata Kaou SISSOKO Page 1 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Fatoumata Kaou SISSOKO Page 2 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Au nom d’Allah, Le Clément, Le Miséricordieux, merci mon Dieu tout puissant de m'avoir donné la force, la bonne santé et le courage de finir ce travail. Prière et bénédictions d’Allah sur le prophète Mohamed, Paix et Salut sur lui. Mon père Feu Macki Kaou SISSOKO , Toutes mes pensées en ce jour se tournent vers toi, Tu nous as quitté très tôt, nous n’avons pas eu cette chance de te connaître en personne mais saches que nous nous faisons une très bonne image de toi à travers tes photos et notre mère et nous sommes très fières d’être tes filles. Ce travail t’est dédié en témoignage de mon profond respect pour ton âme. Saches que tu resteras à jamais gravé dans nos cœurs, dors donc en paix mon papa chéri. Ma mère Fatoumata BOCOUM , Ma petite maman chérie, Les mots me manquent pour t’exprimer toute ma gratitude et mon amour. Courageuse et infatigable, tu es pour moi la mère idéale, tu n’as ménagé aucun effort pour nous donner une meilleure éducation. Tu as su créer en nous l’amour du travail bien fait et nous a guidé avec rigueur mais aussi avec amour. Tu as été toujours là quand nous avions besoin de toi et sans toi, nous ne serions pas devenues ce que nous sommes aujourd’hui. Ce travail est la récompense de tes prières et de tes sacrifices, sois-en fière. Merci encore pour tout. Puisse l’Eternel te récompenser et te garder longtemps parmi nous. Amen. Je t’aime maman. Ma sœur Mariam Kaou SISSOKO , Merci de la fierté que tu portes à mon égard et de m’avoir soutenue durant tout ce temps. J’ai toujours pu compter sur toi quelque soit le moment. Restons unies et soyons à la hauteur de nos parents. Que DIEU te bénisse. Mes oncles Seydou, Sidi BOCOUM et Famille En reconnaissance de votre grande hospitalité. Je me suis toujours sentie chez moi. Merci énormément pour le soutien et la confiance que vous m’avez toujours apportés tout au long de mes études. Seydou Bocoum , papa tu as vraiment été un père pour nous. Que Dieu vous récompense et vous garde très longtemps parmi nous. Mon oncle Abdoulaye Kaou SISSOKO et famille, merci pour votre soutien et votre disponibilité sans failles. Que Dieu vous garde très longtemps parmi nous. Mon oncle Oumar DAFFE et Famille: mon tonton Barou chéri les mots me manquent vraiment. Ton soutien infaillible, ta disponibilité et la confiance que tu as toujours portés à ma personne resteront graver à jamais dans mon cœur. Que Dieu te bénisse, te récompense et te garde très longtemps parmi nous. Merci du fonds du cœur. Fatoumata Kaou SISSOKO Page 3 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Fatoumata Kaou SISSOKO Page 4 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Je remercie tout d’abord Dieu Tout Puissant Familles Sissoko et Bocoum : Vous m’avez accueilli et offert une famille dans laquelle j’ai retrouvé fraternité et réconfort. Recevez ici toute mon affection et ma gratitude. Ma grande mère : Pour sa tendresse et son indéfectible attachement à ma cause. Ses conseils et ses encouragements m’ont toujours accompagné. Merci Dickel. Ada Bocoum et famille : merci énormément pour le soutien et les encouragements que vous m’avez toujours apportés tout au long de mes études. Mes oncles et tantes : Pour le soutien et la confiance qu’ils m’ont toujours apporté tout le long de mes études. Trouvez à travers ce modeste travail, l’expression de ma profonde reconnaissance et le témoignage de mon profond respect. Mes cousins et cousines : Pour tous les moments passés en votre compagnie, ma reconnaissance est infinie, plus particulièrement à Aïssata Sow ma sœur et amie, merci pour tout. A la mémoire de mes grands parents : Que vos âmes reposent en paix. Dr Diakité Chiaka : merci beaucoup tonton les mots me manquent pour t’exprimer ma profonde reconnaissance, merci pour tes conseils, tes encouragements je ne t’oublierai jamais. Au personnel du Département Médecine Traditionnelle : Merci pour tout. Pr Rokia Sanogo, Dr Adjaratou Togola, tonton Fagna et tante Tapa Fané merci pour votre disponibilité, vos conseils et pour la richesse intellectuelle que vous m’avez transmise. Au personnel de l’INRSP (Services de Bactériologie et d’Hématologie) : A ma Tante Kadji Bocoum , tonton Yossi, Dr Diallo, Djibil Dembélé Merci énormément de m’avoir accordés, gratuitement votre temps pour la réalisation de ce travail , merci pour tout. Que Dieu vous bénisse Tout le personnel de la FMPOS plus particulièrement Famalé Dionsan si je ne te remercie pas je serai vraiment ingrate depuis ma première année jusqu’à maintenant tu m’as toujours soutenu et encouragé tu es vraiment l’ami qui me fallait merci pour tes conseils. Tu resteras à jamais graver dans mon cœur. Fatoumata Kaou SISSOKO Page 5 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Tous les enseignants qui m'ont encadré depuis la maternelle à la Faculté FMPOS: Merci pour la richesse intellectuelle que vous m’avez transmise. Dr. Amadou Sékou Traoré : je ne sais comment te remercier. Tu m’as toujours soutenu, encouragé et fait confiance. Merci énormément pour tes conseils, ça m’a vraiment servi. Que Dieu te bénisse. Dr. Danioko et Dr. Ouane : Merci à vous, les conseils et les encouragements. Dr Ousmane Sankaré : merci pour le soutien et le respect que tu portes à ma personne. A mes camarades de la promotion de la FMPOS (Massa Sanogo) : L’entente et la solidarité nous ont permis de surmonter pas mal de difficultés et ont fait la grandeur de notre promotion. Que Dieu nous assiste dans la nouvelle vie qui s’offre à nous. A Mohamed Touré : tu as vraiment été le frère et le meilleur ami que je rêvais d’avoir, merci pour tous ces bons moments partagés je ne t’oublierai jamais. Que Dieu te bénisse. A Abdoulaye Traoré : merci pour ton amitié, ton respect envers ma personne. Que Dieu te bénisse. A mes camarades internes du DMT : Seydou Tangara, Yossi, Maciré Doucouré Merci pour votre amitié et courage pour la suite. A mes cadets de la FMPOS plus particulièrement du DMT et de l’INRSP: Courage ! A tous les étudiants de la FMPOS A tous mes amis du Burkina-Faso, Cameroun, Côte-d’Ivoire, Mali, Niger, et d’ailleurs. J’espère que nous garderons le contact. A tous ceux qui de près ou de loin ont contribué à la réalisation de ce travail dont les noms ne sont pas cités, trouvez ici l’expression de notre profonde reconnaissance A Mon Cher pays le Mali Puisse le Tout Puissant veiller longtemps sur ce pays à qui, nous devons beaucoup Très cordialement! A l’Institut National de Recherche en Santé Publique (INRSP) pour le financement dont nous avons bénéficié pour la réalisation de ce travail. Fatoumata Kaou SISSOKO Page 6 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. Fatoumata Kaou SISSOKO Page 7 Thèse de Pharmacie-2012 Etude de la phytochimie et des activités biologiques de Musa acuminata L., de Mangifera indica L., de Boerhavia erecta L. et de Eclipta prostrata L. A notre Maître et Président du jury Prof. Ibrahim Izetiégouma MAIGA Vice Doyen de la Faculté de Médecine et d’Odontostomatologie Professeur de Bactériologie-Virologie à la Faculté de Médecine et d’Odontostomatologie Chef du Service du Laboratoire de Biologie Médicale et Hygiène Hospitalière du CHU du Point G. Cher Maître, C’est un immense plaisir que vous nous faites en acceptant de présider ce jury malgré vos multiples occupations. Votre bonne humeur inaltérable et contagieuse, votre disponibilité constante à partager la grande expérience scientifique que vous avez, font de vous un maître d’approche facile. Trouvez ici toute notre admiration ainsi que notre profond respect. A notre Maître et Juge Dr. Sékou BAH Maître assistant en pharmacologie à la Faculté de Pharmacie Pharmacologue au CHU du point G, Titulaire d’un master en santé communautaire internationale, Cher Maître, Nous sommes très honorés par votre présence dans ce jury.
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