OKLAHOMA STATE UNIVERSITY DEPARTMENT OF NUTRITIONAL SCIENCES NSCI 3021: AND EVIDENCE-BASED PRACTICE II SPRING 2019

Instructor: Sam Emerson, PhD Office: 417 Human Sciences Phone: 405-744-2303 E-mail: [email protected] Office Hours: Mondays 2:00-4:00 PM or by appointment

Teaching Assistant: Madison Pastor Office: 206 Human Sciences West E-mail: [email protected] Office Hours: Fridays 9:00-10:00 AM or by appointment

Class Section: 22512 Class Meeting Time: Tuesday 9:00-9:50 AM Class Location: HSCI 004A Course Description: Understanding the pathophysiology of chronic disease and the role of nutrition in the prevention and treatment of these diseases. Course builds on an understanding of physiology and of nutrition research from BIOL 3204 and NSCI 3011.

Course Prerequisites: The prerequisites for this course include NSCI 3011 and BIOL 3204.

Course Objectives: By the end of the course, you will be able to:

1) Interpret the findings from original research articles focused on chronic diseases such as atherosclerosis, type 2 , , gastrointestinal diseases, and cancer. 2) Integrate information from physiology (BIOL 3204) and previous nutrition courses in the context of the pathophysiology of disease. 3) Understand the rationale for research design choices, including experimental design and statistical analyses. 4) Discuss the rationale for the use of particular research methods (e.g., nutrition or dietary assessment tools, laboratory techniques) in studies. 5) Identify the role of complementary medicine in disease prevention and/or treatment. 6) Appreciate the importance of scientific evidence provided by all of the different types of research.

TEXT: No textbook is required. Required readings will be assigned from original research articles and different types of review articles. All assigned readings will be posted to Brightspace and should be completed prior to the date that the topic is to be covered in class. If further review materials related to the pathophysiology or nutritional concept are needed, then you should pursue additional resources.

STYLE & MODE OF TEACHING: The class will consist of primarily discussion, small group work and interactive lecture sessions. Students should attend each class having read the assigned readings and prepared to participate in the discussion with questions related to the assigned readings.

ATTENDANCE POLICY: Students are expected to attend class in order to be successful. Excused absences are for university- sponsored activities or medical emergencies only, and these require documentation. Students should notify the instructor in advance of “excused” absences (i.e. before class starts) in order to have the opportunity to earn credit for missed work. The following are specific policies related to attendance:  If your absence is for an excused reason (with documentation) and instructor is notified before the beginning of class: o Your reading assignment will be graded for full credit, as long as it is still submitted to the dropbox on time. o If you missed a quiz, you will be eligible to make up a modified version for full credit during the next week’s office hours. o If you missed miscellaneous/participation points, you will not be able to make these up.  If your absence is not for an excused reason: o Your reading assignment will be graded for 50% credit (i.e. max of 10 points), as long as it is still submitted to the dropbox on time. o If you missed a quiz or miscellaneous/participation points, you will not be able to make these up.

GRADING PROCEDURES: Your final grade will be based on your performance on reading assignments, miscellaneous assignments and a final exam. Grades will be calculated as follows:

Reading Assignments* (10 @ 20 pts each) 200 pts Group Activities/ Miscellaneous Participation 60 pts Quizzes 50 pts Midterm Exam 40 pts Exam 50 pts Total 400 pts

Grading Scale: 90 – 100 % A 80 – 89 % B 70 – 79 % C 60 – 69 % D < 59 % F

*11 readings are assigned; 10 are counted. The lowest grade will be dropped.

Assignment grades are final 2 weeks after being posted to the Brightspace gradebook. In other words, if a student desires to appeal a grade, they must do so within this 2-week window.

READING ASSIGNMENTS: Original research and review articles will be assigned during the semester. Students will be responsible for understanding the concepts in the articles as they relate to the pathophysiology of chronic disease. Eleven research articles (please see schedule below) will be assigned that will require students to demonstrate a fundamental understanding of key components of the reading by participating in discussions in class and by answering the ten questions listed below. A typewritten copy of your answers will be submitted to a Brightspace dropbox prior to class and a hard copy turned in at the beginning of class on the day of the assigned reading. At the top of the page, you should include your name and the citation for the reading. You must be present in class in order to have the chance to get full credit for these assignments and for class participation.

1. In your opinion, did the author(s) provide adequate rationale for the study? 2. What was the purpose(s), research question(s) and/or hypothesis(ses) that is being tested in this research study? 3. What was the study design that was used? 4. Who is the population of interest? 5. What was the primary exposure(s)/ independent variable(s) in the study? 6. What was the primary outcome(s)/ dependent variable(s) in the study? 7. What were the primary statistical tests used? 8. What, in your opinion, were the most important findings? Explain why. 9. What are the implications of this research? Provide the rationale for your answer. 10. On a scale from 1 to 5 with 1 being “completely lacking confidence” and 5 being “very confident,” how confident were you in reading this article, understanding it, and answering questions 1–9?

**Please write in complete sentences and make sure you answer the above questions in your own words. Do not simply copy and paste from the original article.

**Please note that since we will be discussing the answers to the questions above during class, no late assignments will be accepted.

MISCELLANEOUS ASSIGNMENTS/ ACTIVITIES: Various in-class activities will be assigned throughout the semester to provide you with the opportunity to demonstrate your understanding of the material and ability to process and integrate that information into practice. Any required group work will be completed in class. These assignments are designed to help you work toward developing stronger critical thinking skills related to nutrition and the pathophysiology of chronic disease.

QUIZZES: Several small quizzes (5-10 points each, worth a total of 50 points) will be given throughout the semester. These will be given at the beginning of class and will contain a mix of content covered in the previous lecture and the assigned reading for the current week. The purpose of these quizzes is to assess understanding of lecture and reading content, as well as to help prepare students for exams.

EXAMS: Two exams will be given during this semester. A midterm exam will be given the week before spring break, and will be worth 40 points. A final exam will be given during finals week, which will be worth 50 points. The final exam will primarily focus on material from the second half of the course, although please understand that course material builds upon itself, so there will be some skills and principles that carry over from the first half of the course. Exam questions will be very similar in nature to quiz questions.

SPECIAL ACCOMMODATIONS FOR STUDENTS: According to the Americans with Disabilities Act, each student with a disability is responsible for notifying the University of his/her disability and to request accommodations. If any member of a class thinks that he/she has a qualified disability and needs special accommodations, he/she should notify the instructor and request verification of eligibility for accommodations from the Office of Student Disability Services, 315 Student Union. Please advise the instructor of such disability as soon as possible, and contact Student Disability Services, to ensure timely implementation of appropriate accommodations. Faculty have an obligation to respond when they receive official notice of a disability but are under no obligation to provide retroactive accommodations.

If you are experiencing personal situations or academic circumstances that leave you feeling anxious, confused, lonely, angry, depressed, or overwhelmed, please contact the Reboot Center (http://ucs.okstate.edu/index.php/reboot) at (405) 744-6434 or Student Counseling Center (http://ucs.okstate.edu/index.php/counseling) at (405) 744-5472 in the Student Union at University Counseling Services (http://ucs.okstate.edu) at (405) 744-5458.

ACADEMIC INTEGRITY: Oklahoma State University is committed to the maintenance of the highest standards of integrity and ethical conduct of its members. This level of ethical behavior and integrity will be maintained in this course. Participating in a behavior that violates academic integrity (e.g., unauthorized collaboration, plagiarism, multiple submission, cheating on examinations, fabricating information, helping another person cheat, unauthorized advance access to examinations, altering or destroying the work of others, or fraudulently altering academic records) will result in a sanction. Alleged violations of the OSU Academic Integrity policy may subject you to disciplinary action as described in the academic integrity policy; such actions include, but may not be limited to the following: receiving a zero or failing grade on an assignment, examination, course, receiving a notation of a violation of academic integrity on your transcript (F!), and/or being suspended from the University. You have the right to appeal the charge. Contact the Office of Academic Affairs, 101 Whitehurst, (405) 744-5627, or visit http://academicintegrity.okstate.edu.

***Dietetics students should reference the Syllabus Addendum, posted in the course D2L site, for information concerning how this course meets ACEND Student Learning Outcomes.

Tentative Schedule (*Subject to change)

Week Topics and Assignments JANUARY 15 Introduction to the Course 22 Research 101 Assigned Reading: Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults A Randomized 29 Guest Lecture: Library Services on accessing research articles once you leave OSU Location: TBD FEBRUARY 5 Cancer Assigned Reading: Cancer and D supplementation: a systematic review and meta- analysis 12 Neurological Disorders Assigned Reading: Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice 19 Endocrine Disorders (Part 1) Assigned Reading: Therapeutic role of low- ketogenic in diabetes 26 Endocrine Disorders (Part 2) Assigned Reading: , 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus MARCH 5 Cardiovascular Diseases (Part 1) Assigned Reading: Dietary intake of by food source and incident : the Multi-Ethnic Study of Atherosclerosis 12 Midterm Exam 19 ***NO CLASS -- Spring Break*** 26 Cardiovascular Diseases (Part 2) Assigned Reading: Cross-sectional study on the relationship between the Score and blood lipids APRIL 2 Pulmonary Disorders Assigned Reading: Relation between Deficiency and Severity of Chronic Obstructive Pulmonary Disease-A Case Control Study 9 Metabolic Syndrome Assigned Reading: Effects of recommendations to follow the Dietary Approaches to Stop Hypertension (DASH) diet v. usual dietary advice on childhood metabolic syndrome: a randomized cross-over clinical trial 16 Gastrointestinal Disorders Assigned Reading: Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease 23 Miscellaneous Topics Assigned Reading: Choose-your-own article (guidelines to be provided) 30 Course Recap and Review for Final MAY 9 Final Exam: 8:00-9:50 AM (Thursday)