ADDRESSES OF PRESENTING AUTHORS, ORGANIZERS, AND (CO)-EDITORS

Bart Aarts Hakan Aldskogius Utrecht University Univ. of Uppsala Dept. Physiol. Chern. Dept. of Anatomy Stratenum Biomed. Center Universiteitsweg 100 P. O. Box 571 3585 CG Utrecht Uppsala S-75123 The Netherlands Sweden tel. +3130-533634 tel. +46-18-17411 fax. +3130-539035 fax. +46-18-551120 email: [email protected]

Micael Agadjanov Yerevan State Med. Univ. Dept. Biochemistry N. G. Aleksidze Koriun Str. 2 Tbilisi Sl. University Yerevan 375025 Abano 23 Armenia Tbilisi, 280005 tel. +3742-582412 Republic of Georgia fax. +3742-151812 fax. +88-32-233423

Jan Albrecht Med. Research Centre Ruth Hogue Angeletti Polish Acad. Sci Develop. & Mol. Biology Dept. of Neurotoxiocol. Albert Einstein Coil. Med. 5 Pawinskiego Strr. 1300, Morris Park Ave Warsaw 02-106 Bronx, New York 10461 Poland USA tel. +4822-608-6490/668-5323 tel. +1-718-430-3475 fax. +4822-668-5532 fax. +1-718-430-8939/8567 email: [email protected] email:[email protected]

1167 1168 Addresses

Frank Angenstein Mimoun Azzouz Inst. Neurobiology Dept. Immunology Lab. Cell. Signalling Immunopharm. & Pathology Brenneckerstr. 6 POBox 24 Magdenburg 39108 74, Route du Rhin Germany 67401 Illkirch tel. +49-3916263215 France fax. +49-391616160 tel. +33-88-676926 email:[email protected] fax. +33-88-660190 email:[email protected]

Arduino Arduini Herman Bachelard Dept. of Sciences M. R. Centre Dept. of Physics University "G. D. Annunzio" Univ. of Nottingham Viale Pindaro, 42 Nottingham N67 2RD Pescara 65127 United Kingdom Italy tel. +44-115-9514752 tel. +39-691-39-3843 fax. +44-115-9515166 fax. +39-69139-3988 email:ppzwkp@ppn1:nott.ac.uk

P. R. Bar A. V. Arutjunyan Utrecht University Ott Inst. ofObst. & Gynecology Dept. Neurology Mendeleev Line 3 P. O. Box 85500 St. Petersburg 199034 Utrecht 3508 GA Russia The Netherlands tel. +7-812-218-98-91 tel. +3130-2507973 fax. +7-812-218-23-61 fax. +3130-2542100

Ferenc Auth Jolanta Baranska Chern. Works Gedeon Richter Ltd. Nencki Inst. of Exp. Biology Pharmacol. Res. Cetr. Dept. ofMolec & Cell. Neurobiology Gyomroi U. 19021 3 Pasteur Str. H1475 Budapest 10 Warsaw P1-02-093 Hungary Poland tel. +361-261-2199/1813 tel. +48-22-6598571 fax. +361-260-5000 fax. +48-22-225342 email:[email protected] email:[email protected]

Valentina G. Bashkatova N. F. Avrova Russ. Ac. of Med. Scs.lRes. Inst. Russian Acad. of Sciences Lab. Neurochem. Pharm. Inst. of Evol. Physiol. Biochem. Baltiyskaya 8 M. Thorez Avenue 44 Moscow 125315 St. Petersburg 194223 Russia Russia tel. +7-095-155-4797 tel. +7-812-552-7925 fax. +7-095-151-1261 fax. +7-812-552-3012 email:[email protected] Addresses 1169

Etienne Baulieu H. H. Bertet Inserm U. 33 Inst. Pathochem. & Gen. Neurochem. 80, Av. du General Leclerc Dept. of Medicine 94276 Le Kremlin-Bicetre Cedex 1m Neuen Heimer Feld 220/221 France Heidelberg 69120 tel. +33-1-4959-1882 Germany fax. +33-1-45211940 tel. +49-6221-562-595 fax. +49-6221-564-228

Bogdan Beleslin Faculty of Medicine Bruno Berra Dept. of Patho Physiology Inst. Gen. Psysiol. & Biochem Dr. Subotica VII School of Pharmacy Belgrade 11000 Via Trentacoste 2 Yugoslavia Milan 20134 tel. +381-11-648-282 Italy fax. +381-11-684-053 tel. +39-221-40814 fax. +39-221-50-464 email:[email protected] Vladimir Berezin Panum Institute Hanna Bielarczyk Protein Lab. Med. Univ. of Gdansk 3C Blagdamsvej Dept. Clin. Biochem. Bldg. 6. 2 Debinki 7 Copenhagen 2200 N Gdansk 80-211 Denmark Poland tel. +45-3532-7335 tel. +48-58-478-222-ext. 1575 fax. +45-3536-0116 fax. +48-58-449653

J. J. Bergman Kaj Blennow Res. Inst. Neurosciences Dept. ofClinical Neuroscience Free University University ofG6teborg De Boelelaan 1087 G6teborg 1081 HV Amsterdam Sweden The Netherlands tel. +46-31-86-1791 tel. +3120-4447122 fax. +46-31-86-2426 fax. +3120-4447123

Elisabeth Bock Peter Bergqvist Univ. ofCopenhagen Lund Univ. Protein Laboratory Inst. for Clin. Pharmacy Panum Inst. Lund Univ. Hospital 3 Blegdamsvej, BId. 6. 2 Lund S-22185 Copenhagen DK-2200 N Sweden Denmark tel. +46-46-173353 tel. +45-35327-334 fax. +46-46-211-1987 fax. +45-35360-116 1170 Addresses

Leidi Bosch Jean Lud Cadet Solvay Duphar B. V. Neurosciences Branch Cns Farrnakologie Mol. Neuro Chemistry Section C. 1. Van Houtenlaan 36 4940 Eastern Avenue Weesp 1381 CP Baltimore, Maryland 21224 The Netherlands USA tel. +31294-477561 tel. +1-410-550-2953 fax. +31294-410069 fax. +1-410-550-2745/1648

Michael Briley M. Carman-Krzan Centre de Rech. Pierre Fabre Dpet. Pharmacol. Direction Med. Faculty 17 Avenue Jean Moulin Korytkova 2 Castres 81100 Ljubljana France 1000 Slovenia tel. +33-63-714231 tel. +386-61-441-374 fax. +33-63-714209 fax. +386-61-446-082

Stefan Broer Olga V. Chumakova Univ.ofTiibingen Inst. Biochemistry Phys. Chern. Institute Dept. Morphol. & Neurochem Hoppe-Seyler-Str. 4 50 Blk Tiibingen 72076 Grodno 230017 Germany Belarus tel. +49-7071-29-73331 tel. +375-0152-337833 fax. +49-7071-295360 fax. +375- 0152-967322 email:[email protected] email:[email protected]

Annadora J. Bruce Filippo Conti Sanders Brown Center on Aging Dept. ofChemistry Rm 211 / Univ. of Kentucky Univ. "La Sapienza" 800 S. Limestone P. Ie A1do Mora, 5 Lexington, Kentucky 50536-0230 00185 Rome USA Italy tel. +1-606-257-6040 tel/fax +39-6-445-5278 fax. + 1-606-323-2866 email:[email protected]

Peter Brust Gerald Curzon Forschungszentrum Rossendorf Inst. of Neurology POBox 51 01 10 Dept. Neurochemistry Dresden 013 14 I Wakefield Street Germany London WC1N IPJ tel. +49-3512-603452 United Kingdom fax. +49-3512-603452 tel. +44-171-278-1328 email:[email protected] fax. +44-171-278-6572 Addresses 1171

Annica B. Dahlstrom Jan de Vente Univ.ofGoteborg Univ. of Limburg Anatomy Cell BioI. Psych. & Neuropsychol Medicinargatan 3-5 P. O. Box 616 Goteborg 41390 Maastricht 6220 MD Sweden The Netherlands tel. +46-31-7733366 tel. +3143-3881168 fax. +46-31-829690 fax. +3143-3671096

Svetlana Dambinova John de Vries Russian Acad. ofSciences Lab. of Neurobiochemistry Inst. of Human Brain Univ. Hospital Acad. Pavlov Street 12A P. O. Box 30.00 I St. Petersburg 197376 9700 Rb Groningen Russia The Netherlands tel. +7-812-234-9423 tel. +31. 50. 361. 2647 fax. +7-812-234-3247 email:[email protected] Hugo D'haenen Acad. Hospital Free Univ. of Brussels Psychiatric Dept. Pia Davidson Laarbeeklaan 101 Univ.ofGoteborg Brussels 1090 Inst. ofClin. Neuroscience Belgium Dept. of Psych. & Neurochem. tel. +32-2-477-6405 Molndals Sjukhus fax. +32-5230-6440 Molndal 431 80, Sweden tel. +46-31-862-377 fax. +46-31-862-421 Wilfried Diener Eberhard-Karls Univ. Med. Klinik & Poliklinik Annamaria de Luca Abt. Innere Med. II Dept. Pharmacobiologico Otfried Muller Strasse Fac. di Farmacia 72076 Tubingen Universita di Bari Germany Via Orabona 4 tel. +49-7071-2984479 Bari 70125 fax. +49-7071-2982760 Italy tel. +39-80-5442-802 fax +39-80-5442-050/770 Dusan Dobrota Dept. of Biochemistry Jessenius Fac. of Medicine Laura Della Corte Comenius University Dept. Pharmacology Mala Hora 4 Viale G. B. Morgagni 65 0360 I Martin 50134 Firenze Slovakia Italy tel. +42-842-31565 tel. +39-55-4237411/412 fax. +42-842-36770/36332 fax. +39-55-4361613 email:[email protected] 1172 Addresses

Vladimir Dolezal Yves Dunant Inst. ofPhysiology Cas Dept. de Pharmacologie Czech Acad. Sciences Centre Medical Univ. Videnska 1083 1211 Geneve 4 Prague 142 20 Switzerland Czech Republic tel. +41-22-702-5432 tel. +422-475-2573 fax. +41-22-702-5452 fax. +422-471-9517 email:[email protected] email:[email protected] John Dunlop Wyeth-Ayerst. Research Krystyna DomaYzSka-Janik Cns Disorders Med. Res. Centre Cn-8000 Dept. of Neurochemistry Princeton, New Jersey 08543 5, Pawinskiego Str USA Warsaw 02-106 tel. + 1-908-274-4193 Poland fax. +1-908-274-4020 tel. +48-22-608-6528 fax. +48-22-668-5423 Stephen Dunnett Univ. ofCambridge Bas Douma Centro F. Brain Repair Univ. of Groningen Foruie Site, Robinson Way Dept. Animal Physiol Cambridge CB2 2PK Kerklaan 30 United Kingdom Haren 9751 NN tel. +44-1223-33-1160 The Netherlands fax. +44-1223-33-1174 fax. +3150-3635205 email:[email protected]

Karine Dzhandzhugazyan Elizabeth Dovedova Panum Institute Russian Acad. Med. Sciences Protein Lab. Brain Res. Inst. 3c Blagdamsvej Lab. ofCytochemistry Bldg. 6. 2 P. Obukha, 5 Copenhagen 2200 N 103064, Moscow Denmark Russia tel. +45-3532-7343 tel. +7-095-917-9048 fax. +45-3536-0116 fax. +7-095-916-0595

Piet Eikelenboom B. Drukarch Res. Inst. Neurosciences Dept. Neurologie Free Univ. Valeriuskliniek Vrije Universiteit Valeriusplein 9 V. D. Boechorststraat 7 1075 BG Amsterdam 1081 BT Amsterdam The Netherlands The Netherlands tel. +31-20-5736686 tel. +31-20-4448103 fax. +31-20-5736687 fax. +31-20-4448100 email:[email protected] Addresses 1173

Joel Eyer Paul T. Francis Inserm Dementia Research Lab. Dept. Neurobiology Dept. Biochemistry lnserm U298-Chru Umds-Guy's Campus Angers 49033 St. Thomas Street France London SE I 9RT tel. +33-41-35-4726 United Kingdom fax. +33-41-73-1630 tel. +44-171-955-2611 fax. +44-171-955-2600/4191

Matthijs Feenstra Pam Fredman Neth. lnst. for Brain Res. Dept. of Clinical Neurosci. Meibergdreef 33 Section of Psych. & Neurochem. Amsterdam Z. O. 1105 AZ Molndal Hospital The Netherlands 43180 Molndal tel. +31-20-5665500 Sweden fax. +31-20-6961006 tel. +46-31-862415/2419 fax. +46-31-862426

Marianne Fillenz Univ. of Oxford E. M. Fykse Dept. Physiology Norwegian Defence Res. lnst. Parks Road Div. for Environm. Toxicology Oxford OXI 3PT POBox 25 United Kingdom N-2007 Kjeller tel. +44-1865-275908 Norway fax. +44-1865-272469 tel. +47-6380-7845 fax. +47-6380-7811

Abraham Fisher JozsefGaal Israel Inst. for BioI. Research Mega Pharma Dept. of Med. Chemist Baross U 53 P. O. Box 19 1174 Budapest Ness-Ziona 74100 Hungary Israel tel/fax +361-258-4078 tel. +972-8-381-306 email: [email protected] fax. +972-8-401-094

Peter Gebicke-Haerter Ulrich Flogel Univ. of Freiburg Univ. Bremen Dept. of Psychiatry lnst. Org. Chemie Haupstr. 5 NW. 2,Fb 2, P. O. Box 330440 Freiburg D-791 04 Bremen D-28334 Germany Germany tel. +49-761-270-6835 tel. +49-421-2182-951 fax. +49-761-270-6619 fax. +49-421-2184-264 email:[email protected] 1174 Addresses

Lydiya Gershtein Gianfrancesco Goracci Russian Acad. of Med. Sciences Inst. Biochim. Chim. Med. Brain Res. Institute Via Del Giochetto Lab. ofCytochemistry 06122 Perugia P. Obukha 5 Italy 103064 Moscow tel. +39-75-5853420 Russia fax. +39-75-5853428 tel. +7-095-917-9048 fax. +7-095-916-0595 Tatsuya Haga Univ.ofTokyo Antonio Giuditta Dept. Biochemistry Gen. & Environm. Physiology Inst. for Brain Res. Via Mezzocannone 8 7-3-I-Hongo Napoli 80134 Tokoy 113 Italy Japan tel. +39-81-552-6027 tel. +81-356-89-7331 fax. +39-81-552-6194 fax. +81-338-14-8154 email: [email protected]

Anna Maria Giuffrida Stella Anders Hamberger Biochemistry Dept. ofAnatomy & Cell Biology Viale Andrea Doria N. 6 Univ. of Goteborg Catania 95125 Medicinaregatan 5 Italy 41390 Goteborg tel. +39-95-336990 Sweden fax. +39-95-339886 tel. +46-31-853368 fax. +46-31-412805

Albert Gjedde Aarhus General Hospital Bernd Hamprecht Positr. Emis. Tomography Univ.ofTtibingen 44 Norrebrogade Phys. Chern. Inst. Aarhus DK-8000 Hoppe-Seyler-Str. 4 Denmark Ttibingen 72076 tel. +45-8949-3030 Germany fax. +45-8949-3020 tel. +49-7071-292452 email: [email protected]

Steven Goldberg Lise Sofie Haug Preclin. Pharmacol. Lab. Univ.ofOslo Nida Intramur. Res. Progr Neurochemical Lab. 4940 Eastern Ave. Bldg. C P. O. Box 1115 POBox 5180 Blindern Baltimore, Maryland 21224 Oslo N-0317 USA Norway tel. + 1-41 0-550-1522 tel. +47-2285-1097 fax. + 1-410-550-164811563 fax. +47-2285-1436 Addresses 1175

Nariyuki Hayashi Maurice Israel Nihon University Lab. de Neurobiologie Dept. Emercency Med. Cellulaire du CNRS 30 Oyaguchi Kami-Machi 91190 Gif-sur-Yvette Itabashi-Ku France Tokyo 173 tel. +33-1-6982-3650/3662 Japan fax. +33-1-6982-9466 tel. +81-3-3972-8111 fax. +81-3-5995-1069 Natalya Izrarina Heike Heuer Pavlov lost. Psychol. Max-Planck-lost. Funct. Biochemistry Exp. Endokrinol. Nab. Makarova 6 Feodor Lynen Str. 7 St. Petersburg 199034 P. O. Box 610309 Russia Hannover 30603 tel. +7-812-1100-642 Germany fax. +7-812-1100-642 tel. +49-511-5359200 fax. +49-511-5359203 email: [email protected] Agnieszka Jankowska Med. Univ. ofGdansk Herbert Hildebrandt Dept. Clin. Biochem. Univ. Hohenheim Debinki 7 Inst. Zoology Gdansk 80-211 Garbenstr. 30 Poland Stuttgart 70593 tel. +48-58-478222#1575 Germany fax. +48-58-449653 tel. +49-711-459-2255 fax. +49-711-459-3450 email:[email protected] Kent Jardemark Univ. ofGoteborg Inge Huitinga Anat. & Cell Biology Dept. Pharmacology Medicina Regatan 3-5 Faculty of Medicine Goteborg 413. 90 Vrije Universiteit Sweden Van Der Boechorststr. 7 tel. +46-31-773-3370 1081 HV Amsterdam fax. +46-31-773-3330 The Netherlands tel. +31-20-444-8090/8107 fax. +3 1-20-444-8100 Jaak Jiirv Tartu University Michael Hull Inst. Chern. Physics Dept. of Psychiatry 2 Jakobi Str. Univ.ofFreiburg Tartu Ee 2400 Hauptstr.5 Estonia Freiburg 79104 tel. +372-7465-246 Germany fax. +372-7465-247 fax. +49-761-270-6619 email:[email protected] 1176 Addresses

Michael H. Joseph Jan-Olof Karlsson Inst. ofPsychiatry Univ.ofGoteborg Dept. Psychology Inst. Anat. & Cellbiol De Crespigny Park Medicinaregatan 3-5 Denmark Hill Goteborg 41390 London SE5 8AF Sweden United Kingdom fax. +46-31-773-3359 tel. +44-171-919-3414 email:[email protected] fax. +44-171-708-3497 Kiyoshi Kataoka Ehime Univ. School ofMed. Nebojsa Jovic Dept. ofPhysiology Clinic Maxillofacial Surgery Shigenobu Military Med. Academy Onsen-Gun, Ehime 791-02 1100 Belgrade japan Yugoslavia tel. +81-89-960-5240 tel. +381-11-4885-395 fax. +81-89-960-5242 fax. +381-11-4885-395 email:[email protected]

Koichiro Kawashima Romic G. Kamalyan Kyoritsu College of Pharmacy Inst. ofBiochem. Nat. Acad. Sci. Dept. Pharmacology Reg. Enzyme Act. 1-5-30 Shibakoen, Minato-Ku P. Sevak Str. 5/1 Tokyo 105 Yerevan 375044 Japan Armenia tel. +81-3-5400-2674 tel. +374-39-07048 fax. +81-3-5400-2698 fax. +374-39-07047 Elisabeth Kienzl Univ.ofTechnology Baruch I. Kanner Inst. ofAppl. Botany & Techn. Dept. of Biochemistry Microscopy Hebrew University Gertrudemarkt 9 Hadassah Med. School Vienna A-I 060 Jerusalem 91120 Austria Israel tel. +43-1-58801-5068/4770 tel. +972-2-758506 fax. +43-1-587-4835 email:[email protected]

Andrzej Kapuacinski Vladislav Kiselyov Med. Res. Centre Panum Institute Polish Acad. ofSciences Protein Lab. Dept. Neuropathology 3c Blagdamsvej UI. Dworkowa 3 Bldg. 6.2 Warsau 00784 Copenhagen 2200 N Poland Denmark tel. +4822-495410 tel. +45-353-27317 fax. +4822-496973 fax. +45-353-60116 Addresses 1177

Jochen Klein B. Kwiatkowska-Patzer Univ. of Mainz Med. Research Center Dept. Pharmacol. Polish Acad. of Sciences Obere Zahlbacher Str. 67 5 Pawinskiego Str Mainz 0-55101 Warsaw 02-106 Germany Poland tel. +49-6131-174393 tel. +48-22-668-5388 fax. +49-6131-176611 fax. +48-22-668-5532

Siert Knollema Nathalie Lambeng Dept. BioI. Psychiatry Inserm U. 289 University Hospital Hop. de la Salpetriere P. O. Box 30. 001 Batim. Nouv. Pharmacie 9700 RB Groningen 47, Blvd. de I'Hopital The Netherlands Paris 75651 fax. +31-50-3696727 France tel. +331-42-16-2202 fax. +331-44-24-3658 Edward Koenig email:[email protected] Neurobiology Lab. State Univ. of New York 3 13 Cary Hall Adriaan A. Lammertsma Buffalo, New York 14214 Free University Hosp. USA P.O. Box 7057 tel. +1-716-829-3572 1007 MB Amsterdam fax. + 1-716-829-2344 The Netherlands

Hermann Koepsell Inst. of Anatomy Risto Lammintausta University Wurzburg Orion Corporation Koellikerstr. 6 Orion Pharma Res. & Development 0-97070 Wurzburg P. O. Box 425 Germany 20101 Turku tel. +49-931-312700 Finland fax. +49-931-572338 tel. +358-212-72-7528 fax. +358-212-72-7432

Jaap Korf Dept. of BioI. Psychiatry A. Lapidot University Hospital Weizmann Inst. of Science 9713 EZ Groningen Dept. ofOrganic Chemistry The Netherlands Rehovot76100 tel. +31. 50. 361. 2100 Israel fax. +31. 50.363.6905 tel. +972-8934-3413 [email protected] fax. +972-8934-4142 1178 Addresses

Robert O. Law Giulio Levi Univ. ofLeicester Neurobiol. Section Cell Phys. & Pharmacol. Lab. of Pathophysiology P. O. Box 138 Inst. Superiore di Sanita Leicester LE I 9HN Viale Regina Elena, 299 United Kingdom Roma 00161 tel. +44-116-252-3076 Italy fax. +44-116-252-5045 tel. +39-649-902488 fax. +39-649-902071

Jerzy W. Lazarewicz Med. Res. Centre Moti Liskovitch Dept. of Neurochemistry Weizmann Inst. of Sciences 5, Pawinskiego Str Dept. Hormone Res. Warsaw 02-106 PO Box 26 Poland Rehovot76100 tel. +4822-608-6528 Israel fax. +4822-668-5423 tel. +972-8-483-182 fax. +972-8-466-966

Ken Lee Konrad Loffelholz Gifu Univ. School of Med. J. Gutenberg Univ. Mainz Dept. Physiology Pharmakol. Inst. 40 Tsukasa-Machi Obere Zahlbacherstr. 67 Gifu 500 D-55101 Mainz Japan Germany tel. +81-58-265-1241 fax. +49-6131-176611 fax. +81-58-265-9004

John P. Lowry Jan Lehotsky Univ. of Oxford Comenius University Dept. Physiology Jesenius Med. Faculty Parks Road Dept. Medical Biochemistry Oxford OXI 3PT Mula Hora 4 United Kingdom Sk-0360 1 Martin tel. +44-1865-275907 Slovakia fax. +44-1865-272469 tel. +42-842-31565 fax. +42-842-36770 Paul Luiten Univ. ofGroningen Anne S. Lesage Dept. Animal Physiology Janssen Res. Foundation Kerklaan 30 Dept. Biochem. Pharmac 9751 NN Haren Turnhoutseweg 30 The Netherlands Beerse B-2340 tel. +31-50-3632359/2340 Belgium fax. +31-50-3635205 fax. +32-14-605-380 email:[email protected] Addresses 1179

Nadezda Lukacova Andrzej Malecki Inst. of Neurobiology, SAS Silesian Acad. ofMedicine Dept. Biochemistry Dept. Pharmacology Soltesovej 4 Medyk6w 18 Kosice 040 0 I Katowice 40-752 Slovak Republic Poland tel. +42-95-765-064 tel. +48-32-1523835 fax. +42-95-765-074 fax. +48-32-1523835

Alia Lysenko M. Marangolo Neurocybernetics Res. lost. Trinity College Phys. & Biochemistry Biochem. Dept. Stachki Ave. 194/ I Dublin-2 Rostov-on-Don 344090 Ireland Russia tel. +353-1-608-1802 tel. +7-8632-24-46-93 fax. +353-1-677-2400 fax. +7-8632-22-04-24/25-47-23 email:[email protected]

Adriana Maggi Gerard J. M. Martens lost. Pharmacol. Sci. /Center MPL Univ.ofNijmegen University ofMilan Dept. Animal Physiol. Via Balzaretti 9 Toernooiveld Milan 20133 6525 ED Nijmegen Italy The Netherlands tel. +39-2-204-88375 tel. +31-24-365260 I fax. +39-2-204-88249 fax. +31-24-3652714 email:[email protected]

Pierre Magistretti Rainer Martin Inst. of Physiology Univ. Ulm 7, Rue du Bugnon Sekt. Electr. Microscopy Lausanne 1005 Albert-Einstein-Allee II Switzerland Ulm D-89069 tel. +41-21-692-5542 Germany fax. +41-21-692-5595 tel. +49-731-502-3441 fax. +49-731-502-3383

Kalman Magyar Semmelweis Univ. of Medicine Angelo R. Massaro Dept. of Pharmacodynamics Policlinico Gemelli Nagyvarad Ter 4 Dept. Neurology Budapest 1089 Univ. Sacro Cuore Hungary Roma 1-00168 tel. +361-210-4411 Italy fax. +361-210-4411 tel. +39-330-423240 email:[email protected] fax. +39-6-338-5411 1180 Addresses

E. R. Mattarredona Andre Menez Fac. de Farmacia Dept. d'Ingenierie Et Dept. Bioquimica D'Etudes des Proteines C/Prof. Garcia Gonzalez Cea-Saclay 41012 Sevilla 91191 Gif-sur-Yvette Spain France tel. +34-5-4511580 tel. +33-1-6908-9961 fax +34-5-4233765 fax. +33-1-6908-9137

Amanda Mcrae-Dequerce Daniel M. Michaelson Univ. ofGoteborg Tel Aviv University Anatomy & Cell BioI. Dept. Dept. ofNeurobiochemistry Medicinargatan 3-5 RamatAviv Goteborg 41390 Tel Aviv 69978 Sweden Israel tel. +46-31-7733354 tel. +972-3-6409624 fax. +46-31-829690 fax. +972-3-6407643 email:[email protected]

Karine Melkonian Mirjana Mijanovic State Medical Univ. Dept. of Pharmacology Dept. Pharmacology Med. Faculty 2, Korjun St. Cekalusa 90 Yerevan 375025 Sarajevo Armenia Bosnia Herzegovina tel. +3742-560860/521711 tel. +387-71-441-895 fax. +3742-151812 fax. +387-71-663-625

M. M. Melkonian Jan Minderhoud State Med. University Dept. of Neurology Dept. Chemistry University Hospital 2, Korjun Str. 9713 BZ Groningen Yerevan 375025 The Netherlands Armenia tel. +31. 50. 361. 2430 tel. +3742-580343 fax. +31. 50. 361. 1707 fax. +8895-529803

Alexander Mendzeritsky M. Teresa Miras-Portugal Neurocybemetics Res. Inst. Universidad Complutense de Madrid Phys. & Biochemistry Dept. de Bioquimica Stachki Ave. 194/1 Facultad Veterinaria Rostov-on-Don 344090 Madrid 28040 Russia Spain tel. +7-8632-24-46-93 tel. +34-1-394-38-94 fax. +7-8632-22-04-24/25-47-23 fax. +34-1-394-39-09 Addresses 1181

Analtoly Mokrushin Hiroaki Naritomi Pavlov Inst. of Physiology Nat. Cardiovascular Center Higher Nervous Act. Cerebral Circ. Lab Nab. Makarova 6 5-7-1 Fujishiro-Dai St. Petersburg 199034 Suita, Osaka 565 Russia Japan tel. +7-812-707-28-06 tel. +81-6-833-5012/872-0010 fax. +7-812-218-05-01 fax. +81-6-872-7485 email:[email protected]

J. Molgo V. I. Nazarenko Lab. de Neurobiologie 9, Leontovichstr. Cell. Et Moleculaire Kiev 252030 C.N.R.S. Ukraine I, Ave de La Terrasse tel. +380-44-224-50-10 91198 Gif-sur-Yvette fax. +380-44-229-63-65 France tel. +33-1-69-823-030 fax. +33-1-69-829-466 email:[email protected] Jerzy Z. Nowak Polish Academy ofSciences Dept. ofBiog. Amines A. Morgan Tylna 3, POBox 225 Physiological Laboratory Lodz 90-950 University ofLiverpool Poland POBox 147 tel. +48-42-817006 Liverpool L69 3BX fax. +48-42-815283 United Kingdom tel. +44-151-794-5333 fax. +44-151-794-5337 Csaba Nyakas Katarzyna Nalecz Haynal Univ. Health Sci. Nencki Inst. of Exp. Biology Centro Research Dept. Muscle Biochem SzaboIcs U. 35 Pasteur Str. 3 P. O. Box 112 Warszawa PI-02-093 Budapest H-1389 Poland Hungary tel. +48-22-659-8571 tel. +261-1290222 fax. +48-22-225342 fax. +261-1208246

Natalia Nalivaeva Inst. ofEvolutionary Physiology Barbara Oderfeld-Nowak & Biocehmistry Nencki Inst. Exp. BioI. M. Thorez Av. 44 Dept. Neurophysiolog St. Petersburg 3, Pasteur Str. Russia Warsaw 02093 tel. +7-812-552-7925 Poland fax. +7-812-552-3012 tel. +48-22-659-871 email:[email protected] fax. +48-2-222-5342 1182 Addresses

S.Ohman Mariusz Papp Elfin Lab. Polish Acad. Sciences POBox 133 / Evastigen 9 Inst. of Pharmacology S 59070 Ljungsbro 12 Smetna Street Sweden Krakow 31-343 tel. +46-13-219020 Poland fax. +46-13-219021 tel. +48-12-374550 fax. +48-12-374500

Simon S. Oja Univ.ofTampere Marion Paturneau-Jouas Med. School Inserm 134 P. O. Box 607 Hop. Salpetriere Tampere FIN-33101 47, Blvd. de I'Hopital Finland F 75651 Paris tel. +358-31-215-6694 France fax. +358-31-215-6170 tel. +33-1-42162157 fax. +33-1-45848008 email:[email protected] Bart-Jan Oosterink A.Z.G. Giancarlo Pepeu Dept. Neurology Univ. of Florence Hanzeplein I Dept. Pharmacology 9700 RB Groningen Viale Morgagni 65 The Netherlands Florence 50134 tel. +3150-3624525 Italy fax. +3150-3636905 tel. +39-55-4237-418 fax. +39-55-4361-613

Luis M. Orensanz Hosp. Ramon y Cajal Anna Petroni Dept. Investigacion lnst. Pharm. Sciences Carretera de Colmenar Km. 9 Via Balzaretti 9 Madrid 28034 20133 Milan Spain Italy tel. +34-1-336-8684 tel. +39-2-20488307 fax. +34-1-336-9016 fax. +39-2-29404961

Neville Osborne Nina Popova Univ. ofOxford Inst. ofCytology & Genetics Nuffield Lab. ofOphtalmology Behavioral Phenogen. Wahon Street Pro Lavrentyeva 10 Oxford OX2 6AW Novosibirsk 630090 United Kingdom Russia tel. +44-1865-248-996 tel. +7-3832-354-753 fax. +44-1865-794-508 fax. +7-3832-356-558 email:[email protected] email:[email protected] Addresses 1183

Soren Prag Ciaran Regan Panum Institute Univ. College Protein Lab. Dept. Pharmacology 3C Blagdamsvej Belfield Bldg. 6. 2 Dublin 4 Copenhagen 2200 N Ireland Denmark tel. +353-1-706-1619 tel. +45-3532-7322 fax. +353-1-269-2749 fax. +45-3536-0116 email:[email protected]

Alexander Pylaev Russian State Med. University H. Reiber Dept. Morphology Lab. ofNeurochemistry Ostrovityanova Str. 1 University Gottingen Moscow 117869 Robert-Koch-Str. 40 Russia Gottingen D-37075 tel. +7-095-434-0037 Germany fax. +7-095-434-4787 tel. +49-551-39-6619 fax. +7-095-131-4863 fax. +49-551-39-2028 email:[email protected] Russel J. Reiter Fenna Radhakishun Dept. Cell. & Structural Biology Organon International Univ. Texas Medical R&D Unit Health and Science Center P. O. Box 20 7703 Floyd Curl Dr 5340 BH Oss San Antonio, Texas 78284 The Netherlands USA tel. +31-412-661754 tel. +1-210-567-3854 fax. +31-412-662555 fax. +1-210-567-6948 Hinrich Rahmann Univ. Hohenheim Christiane Richter-Landsberg Inst. Zoology Univ.ofOldenburg Garbenstr. 30 Dept. of Neurobiol. Stuttgart 70593 P. O. Box 2503 Germany Oldenburg D-26111 tel. +49-711-459-2255 Germany fax. +49-711-459-3450 tel. +49-441-798-3422 fax. +49-441-798-3423 Rona R. Ramsay Univ. of St. Andrews School of Biomedical Sciences George Robillard Div. Cell & Mol. Biology Biochemical Lab. Groningen Irvine Building Biomol. Sciences & Biotechn. St. Andrews KYI6 9AL Nijenborgh 4 United Kingdom/Scotland 9747 AG Groningen tel. +44-1334-463411 The Netherlands fax. +44-1334-463400 tel. +31-50-363-4321 email:[email protected] fax. +31-50-363-4165 1184 Addresses

Hans RQUema Rupert Schmidt Pfizer Inc. lentr. Biotechn. Betriebseinheit Dept. of Neurosci. 1m Strahlenzentrum Eastern Point Rd. Justus-Liebig Univ. Groton, Connecticut 06340 Leihgesterner Weg 217 USA 0-35392 Giessen tel. +1-860-441-6374 Germany fax. +1-860-441-1773 tel. +49-641-99-16500 email:[email protected] fax. +49-641-99-15009 email:[email protected]

Slavwomir Rump Arne Schousboe Mil. Inst. of Hygiene & Epidem. Dept. ofBiol.fNeurobiol. Unit Pharmacol. & Toxicol. Royal Danish School ofPharm. Kozielska 4 2, Universitetsparken Warsaw 01-163 2100 Copenhagen Poland Denmark fax. +48-22-104391 tel. +45-3537-6777 ext. 330 fax. +45-3537-5744

Eric Salmon Peter Schubert Univ. of Liege Max-Planck-lnst. Psych. Cyclotron Res. Ctr Dept. Neuromorphol. B30 Sart Tilman Am Klopfersmitt 18A Liege 4000 Martinsried 82152 Belgium Germany tel. +32-41-66-36-87 tel. +49-89-8578-3689 fax. +32-41-66-29-46 fax. +49-89-8578-3939 email:[email protected]

V. Sanchez-Margalet Constanze Seidenbecher Dept. Biochem. & Molec. Biology Otto Von Guericke University Med. School Univ. SeviHa inst. Med. Psychology Av. Sanchez Pizjvan 4 Leipzigerstr. 44 Sevilla 41009 Magdeburg 39120 Spain Germany tel. +34-5-4557-356 tel. +49-391-626-3223 fax. +34-5-4557-481 fax. +49-391-626-3229

Philippe Siaud Reinhard Schliebs Inserm U. 297 Paul Flechsig Inst. Brain Res. Neuroendocrinol. Exp. Dept. Neurochemistry Uer de Medecine Nord. Jahn AHee 59 Blvd. P. Dramard Leipzig 04109 13916 Marseille Cedex 20 Germany France tel. +49-341-9725-766 tel. +33-91-654311 fax. +49-341-211-4492 fax. +33-91-698712 Addresses 1185

Jerzy Silberring G. T. Snoek Karolinska Inst. Centre for Biomembranes and Drug Dependence Res. Lipid Enzymology Stockholm 171 76 Dept Biochemistry of Lipids Sweden Padualaan 8 tel. +46-8-729-4698 3584 CH Utrecht fax. +46-8-341-939 The Netherlands tel. +31-30-253-3445/253-4668 fax. +31-30-252-2478 Alexander Sinichkin State University Hermona Soreq Dept. Biochemistry Hebrew University Gorkogostr. 202 Kv. 141 Dept. BioI. Chern. Rostov-on-Don 344022 Givat Ram Russia Jerusalem 91904 tel. +7-8632-537320 Israel fax. +7-8632-649877 tel. +972-2-658-5109 fax. +972-2-6520258

D. A. SivaI Micha E. Spira Dept. ofNeurology Hebrew Univ. ofJerusalem Academic Hospital Dept. Neurobiology Hanzeplein 1 Life Sciences lost. 9700 RB Groningen Givat Ram The Netherlands Jerusalem 91904 tel. +31-50-3612464 Israel fax. +31-50-3611707 tel. +972-2-6585091 fax. +972-2-637033 email:[email protected] Malgorzata Skup Nencki Inst. of Exp. Biology Dept. Neurophysiol. Jeffrey Sprouse M. Pasteura 3 Pfizer Inc. Warsaw 02-093 Dept. Neurosci. Poland 558 Eastern Point Rd. tel. +482-659-85-71 ext 360 Groton, Connecticut 06340 fax. +4822-225342 USA email:[email protected] tel. +1-860-441-6373 fax. +1-860-441-1 017 email:[email protected] Karl-Heinz Smalla Inst. Neurobiology R. Srapionian Dept. NeurochemiMol. B Inst. Biochemistry Brenneckerstr. 6 Nat. Acad. Sci Magdeburg 39108 5/1 Serag Str. Germany 375014 Yerevan tel. +49-391-626-3215 Armenia fax. +49-391-626-3229 tel. +3742-281840 email:[email protected] fax. +3742-281951 1186 Addresses

P. Stinissen Joanna Sypecka Multiple Sclerosis Res. Med. Res. Centre Dr. L. Willems Instituut Dept. ofNeurochemistry Universitaire Campus 5, Pawinskiego Str Drepenbeek Warsaw 02-106 Belgium Poland tel. +32-11-269211 tel. +48-22-608-6528 fax. +32-11-269209 fax. +48-22-668-5423

Hans Stoof Andrea Csilla Szabo Research Inst. Neurosciences BioI. Res. Center Dept. of Neurology Inst. ofBiophysics Free University Temesvazi Krt 62 De Boelelaan 1087 P. O. Box 521 1081 HV Amsterdam Szeged H-6701 The Netherlands Hungary tel. +31-20-444-8360 tel. +36-62-432232/433465 fax. +31-20-444-8100 fax. +36-62-433-133

Paul J. L. M. Strijbos Cruciform Project Neurosci. Res. Andrzej Szutowicz Inst. Neurology Med. Univ. ofGdansk Univ. College London Dept. Clin. Biochem. I, Wakefield Street Debinki 7 WCIN IPJ London Gdansk 80-211 United Kingdom Poland tel. +44-171-837-3611 ext. 4954 tel. +48-58-478222 #1575 fax. +44-171-837-1347 fax. +48-58-449653 email:[email protected] email:[email protected]

Joanna B. Strosznajder Takao Taki Polish Ac. of Sciences Tokyo Med. and Dental Univ. MRC, Dept. ofCellular Signalling Dept. Biochemistry Pawinskiego 5 1-5-45, Yushima, Bunkyo-Ku Warszawa 02-106 Tokyo 113 Poland Japan tel. +48-22-608-6414 tel. +81-3-5803-5165 fax. +48-22-668-5223/5423 fax. +81-3-5803-0129

Bauke Stuiver BioI. Centre Albert Teelken Dept. Animal Fysiol. Lab. Center University ofGroningen Section ofNeurochemistry Kerklaan 30/ P. O. Box 14 University Hospital 9750 AA Haren 9713 GZ Groningen The Netherlands The Netherlands tel. +3150-3632363 tel. +31-50-361-2647 fax. +3150-3635205 fax. +31-50-361-1707 Addresses 1187

Gert J. ter Horst w. Tischmeyer University Hospital Federal lost. Neurobiology Dept. BioI. Psychiatry POBox 1860 Hanzeplein I D-39008 Magdeburg P. O. Box 30. 001 Germany 9700 RB Groningen tel. +49-391-6263222 The Netherlands fax. +49-391-6263229 tel. +31-50-361-2105/1533 email:[email protected] fax. +31-50-361-1699 email:[email protected] Maria Tomaszewicz Med. Univ. ofGdansk Guido Tettamanti Dept. Clin. Biochem. Dept. Medical Chemistry Debinki 7 & Biochem. Univ. of Milano Gdansk 80-211 Via Saldini 50 Poland Milano 20133 tel. +48-58478222 #1575 Italy fax. +48-58-412915/449653 tel. +39-2-7064-5247 fax. +39-2-236-3584 Jack C. de la Torre Georg G. Thakhava Univ. of New Mexico Sarajishrili lost. ofNeurology Dept. Neursurgery Dept. Angioneurology 2211 Lomas, N.E. 2a, Guda Mataristr. Albuquerque, New Mexico 87131 Tbilisi 380092 USA Republic ofGeorgia tel. + 1-505-277-0043/5752 tel. +88-32-371936 fax. +1-505-277-3891 fax. +88-32-233423 email:[email protected]

Keith Tipton Nina Tsakadze Trinity College Sarajishvili Inst. of Neurol. Dept. Biochemistry Dept. Angioneurology Dublin 2 2a Gudamakari St. Ireland Tblisi 380092 tel. +353-1-608-1608 Rep. ofGeorgia fax. +353-1-677-2400 tel. +995-8832-618114 email:[email protected] fax. +995-32-00 I027/001153

F. Titgemeyer Dept. Biochemistry Stanislav Tu~ek Universiteit Groningen lost. of Physiology Nijenborgh 4 Dept. Neurochemistry 9747 AG Groningen Videnska 1083 The Netherlands Prague 14220 tel. +31-50-363-4170 Czechia fax. +31-50-363-4165 tel. +42-02-4752620 email:[email protected] fax. +42-02-4752488 1188 Addresses

Hayrettin Tumani Clementina M. Van Rijn Georg-August Univ. University ofNijmegen Neurochem. Lab. Nici/Comp. & Physiol. Psychology Robert-Koch-Str.40 P. O. Box 9104 Gottingen D-37075 6500 HE Nijmegen Germany The Netherlands tel. +49-551-396619 tel. +31-24-361-56 12 fax. +49-551-392028 fax. +31-24-361-6066 email:[email protected]

Tony Turner Univ. of Leeds Vince Varga Dept. Biochem. & Mol. Biology Dept. Physiol./Tampere Brain Leeds LS2 9JT Res. Center/Univ. ofTampere United Kingdom Med. School tel. +44-113-233-3131 P. O. Box 607 fax. +44-113-242-3187 Tampere FIN-33101 email:[email protected] Finland tel. +358-31-2156639 fax. +358-31-2156170 Anatoly Uzdensky Inst. of Neurocybernetics Rostov University Roland Vogel 194/1 Stachky Ave. Univ. ofTiibingen Rostov-on-Don 344090 Physiol. Chern. Inst. Russia Hoppe-Seyler-Str. 4 tel. +7-8632-280577 Tiibingen 72076 fax. +7-8632-280367 Germany email:[email protected] tel. +49-7071-293042/2972452 fax. +49-707 I -295360

Anne-Marie Van Dam Free Univ. A'dam Petra Vohringer Res. lost. Neuroscience Univ. Hohenheim Dept. Pharmacology lnst. Zoology Van der Boechorststraat 7 Garbenstr. 30 1081 BT Amsterdam Stuttgart 70593 The Netherlands Germany tel. +3 I 20-444-8095 tel. +49-711-459-2255 fax. +3120-444-8100 fax. +49-711-459-3450

B. W. Van Oosten Walter Volknandt Dept. ofNeurology Biozentrum, Zool. lost. Free University Hospital Ak Neurochemie POBox 7057 Marie-Curie-Str. 9 / N21 0 1007 MB Amsterdam Frankfurt am Main D-60439 The Netherlands Germany tel. +31-20-444-4444 ext. 455 tel. +49-69-798-29603 fax. +31-20-444-0197 fax. +49-69-798-29606 Addresses 1189

Cinzia Volonte Heinrich Wiesinger Inst. ofNeurobiology C.N.R. Physiological-Chern. lost. Viale Marx 43-15 Univ. of Tiibingen Rome 00137 Hoppe Seyler Str. 4 Italy Tubingen D-72076 tel. +396-868-95963 Germany fax. +396-3243675 tel. +49-7071-2973338 email:[email protected] fax. +49-7071-295360

J. S. Wassenaar David C. Williams BCN-Med. Faculty Univ. of Dublin Dir. Neuro- & Psychobiology Biochemistry Dept. Bloemsingel I Trinity College 9713 BZ Groningen Dublin 2 The Netherlands Ireland tel. +31-50- 363-2779 tel. +353-1-772941 ext. 1802 fax. +31-50-5272527 fax. +353-1-772400

Hiroshi Watanabe Toyama Med. Pharmaceut. Univ. Dr. Paul Willner Res. Inst. Orient. Med Dept. Psychology 2630 Sugitani Univ. College ofSwansea Toyama 930-01 Swansea 8A2 8PP Japan United Kingdom tel. +81-764-34-2281 tel. +44-792-295844 fax. +81-764-34-5056 fax. +44-792-295679

Hans Welzl David Robert Wing Eth Behavioral Biology Lab. Glyco Biology Inst. Dept. ofToxicology Dept. Biochemistry Schorenstr. 16 South Parks Rd. Schwerzenbach 8603 Oxford OXI 3QH Switzerland United Kingdom tel. +44-1-8257328 tel. +44-1865-275756/275762 fax. +44-1-8250476 fax. +44-1865-275216 email:[email protected]

Dr. Ben H. C. Westerink Hans Winkler Univ. ofGroningen Inst. Fur Pharmakologie Dept. of Pharmacy Univ. Innsbriick T.A Deusinglaan I Peter-Mayr Str. IA 9713 AW Groningen A-6020 Innsbruck The Netherlands Austria tel. +31-50-363-3307 tel. +43-512-507-3700 fax. +31-50-363-6908 fax. +43-512-507-2868 II90 Addresses

Susan Wonnacott Teresa Zalewska Univ. of Bath Med. Res. Centre Dept. Biochemistry Dept. of Neurochemistry Bath BA2 7AY 5, Pawinskigo Str United Kingdom Warsaw 02-106 tel. +44-1225-826391 Poland fax. +44-1225-826779 tel. +48-22-608-6528 email:[email protected] fax. +48-22-668-5423

V. A. Zammit Martyn Wood Hannah Research Inst. Smithkline Beecham Ayr KA6 5HL Psych. Res. Scotland/U.K. Third Avenue tel. +44-1292-476013 #254 Harlow, Essex CMI9 5AW fax. +44-1292-678797 United Kingdom email:[email protected] tel. +44-1279-622247 fax. +44-1279-622230 Mzia G. Zhavania Dept. of Brain Structure Res. Elena Ivanova Yerlykina Inst. of Physiology Medical Academy Georgian Acad. ofSciences Dept. of Biochemistr 14, Gotuastr. Brinsky Str. 4/1-6 380060 Tbilisi Nizhy Novgorod 603163 Republic ofGeorgia Russia fax: +995-3200-1153/1 027 fax. +7-831-239-0943 Herbert Zimmermann Biozentrum 1. W. Goethe Univ. Bernard Zalc Zoologisches Inst. Lab. de Neurochimie Ak Neurochem. Inserm U-134 Marie-Curie-Str. 9 H6pital de la Salpetriere D-60439 Frankfurt-am-Main 47, Blvd. de I'Hopital Germany 75651 Paris Cedex 13 tel. +49-69-798-29602/1 France fax. +49-69-798-29606 tel. 33-1-4586-2012 email:h.zimmennann fax. 33-1-4583-7660 @zoology.uni-frankfurt.d400.de AUTHOR INDEX

Aarts, L.H.J., 1107 Becker, e.G., 863 Brugg, B., 259 Abraham, C.S., 479 Begeer, J.H., 475 Brust, P., 1149 Agadjanov, M.I., 1019 Beleslin, B.B., 983 Bubser, M., 1161 Agid, Y., 259 Belik,Ya.V.,9 Burgoyne, R.D., 719 Agrati, P., 523 Benbassat, D., 647 Burov, Y.V., 345 Ahier, R.G., 1157 Benech, J.C., 643 Butterworth, R.F., 201 Akhalkatsi, R.G., 909 Bengtsson, F., 201 Buwalda, B., 147 Aldskogius, H., 549 Berent, U., 1059 Aleksidze, N.G., 909 Berenyi, S., 215 Cadet, J.L., 323 Alvarez, J., 643 Berezin, V., 295, 857, 891, 897 Calvani, M., 1053, 1065 Angenstein, F., 1071 Berg, P.A., 281 Cano, J., 309 Anglade, G., 63 Berger, M., 27, 535 Capuani, G., 1065 Anglade, P., 259 Bergman, lJ., 655 Carman-Krfan, M., 501 Annett, L.E., 249 Bergmann, R., 1149 Carnevale, A., 451 Apelqvist, G., 201 Bergqvist, P.B.F., 201 Cazevieille, e., 611 Arduini, A., 1053 Berlet, H.H., 111I Charyeva, I.G., 853 Arendash, G.W., 33 Berners, M.O.M., 561 Chekulaeva, U., 919 Artola, A., 863 Berra, B., 913 Chen, Y., 21 Arutjunyan, A.V., 457, 529 Bianchi, L., 949, 955 Chen, Y.-J., 929 Audet, R.M., 201 Bielarczyk, H., 737, 821, 993 Chumakova, O.V., 837 Aureli, T., 1065 Bigl, V., 829 Clark, R.A.e., 929 Auth, F., 215 Bittar, P.G., 555 Colivicchi, A., 955 Avgustinovich, D.F., 209 Blasevich, M., 1005 Colombo, I., 913 Avrova, N.F., 973 Blennow, K., 39, 415 Conte Camerino, D., 461 Azuhata, T., 97 Blomgren, K.• 415 Conti, F., 1065 Azzouz, M., 485 Bock, E., 295, 451, 707,857,891, Conti, R., 1053 897 Cooper, T., 315 Bachelard, H., I Boer, A.-K., 773 Crandall, B.M., 33 Baker, e.R., 773 Bolam, J.P., 949, 955 Crispino, M., 637, 643 Balshiisemann, U., 925 Boldyrev, A.A., 177 Csutoras, Cs., 215 Baranowska, B., 137 Bolotashvili, T., 909 Curzon, G., 187 Barahska, J., 1011 Borg, J., 485 Czarny, M., 1011 Barcikowska-Litwin, M., 137 Bosch, A.!., 59 Bardahchjan, E.A., 291 Botterblom, M., 1161 D'Amico, T.• 583 Barrio, L.e., 1123 Boutelle, M.G., 561 Dahlstrom, A., 1101 Bartolini, P., 955 Brammer, N., 1089 Dambinova, SA, 265, 281 Bashkatova, V., 977 Braun, N., 701 Danneberg, U., 281 Bastiaens, P.I.H., 999 Briley, M., 193 Datla, K.P., 1157 Bauer, J., 27, 105,967 Broer, S., 619 Dauplais, M., 783 Bauer, K., 691 Brown, A.M., 69 Davidsson, P., 39 Bauer, R., 1149 Bruce, A.J., 165 De Groot, C.J.A., 967

1191 1192 Author Index

De Jongste, MJ.L., 141 Galli, e., 1005 Jacobson, I., 1131 De la Torre, 1.e., 173 Galoyan, A., 595 Jakowic, I., 55 Deli, M.A., 479 Gamier, M., 523 Janaky, R., 733 Della Corte, L., 949, 955, 959 Gaynullin, M.R., 757 Jankowska, A., 737, 847, 993 De Luca, A., 461 Gebicke-Haerter, PJ., 535 Janson, I., 415 Demestre, M., 561 Geraerts, W.P.M., 655 Jardemark, K., 1131 De Vries, J., 125 Gerardy-Schahn, R., 885 Jarv, J., 791 De Vries, KJ., 999 Gershtein, L.M., 161 Jellinger, K., 33 Di Cocco, M.E., 1065 Gispen, W.H., 1107 Jo, N., 97 Diener, W., 281 Giuditta, A., 637, 643 Johannsen, 8., 1149 Dijk, S.N., 153 Glinkina, V.V., 853 Joo, F., 479 Dijkstra, e.D., 105,967 Glushchenko, T.S., 797 Joseph, M.H., 1157 Dirksen, R., 275 Gobema, R., 589 Jovanovic, Z., 983 Dixon, H.8.F., 959 Goldberg, S.R., 327 Jovic, N., 469 Dobrota, D., 177 183 Goracci, G., 1029 Jovic, R., 469 Dohovics, R., 733 Gordon-Krajcer, W., 361 Jozanc, Lj., 963 Dolezal, V., 843, 987 Gottfries, e.G., 415 Juric, D.M., 501 Domailska-Janik, K., 233, 369, Gray, J.A., 1157 407 Grimm, R., 1117 Kalaony, T., 605 Dormann, A., 647 Gromova, L.G., 265 Kamalyan, R.G., 1077 Dottori, S., J053 Gundelfinger, E.D., 901, 1117 Kameyama, K., 807 Douma, 8.R.K., 401,507 Gurney, M., 491 Kanayan, A.S., 1083 Dovedova, E.L., 287 Gyulkhandanyan, A.V., 1077 Kaplan, B.B., 643 Drukarch, B., 243 Kaplan, P., 375, 383 Dubrovskaya, N., 919 KapuSciriski, A., 729 Haas, U., 1II1 Dunlop, 1., 1089 Karageuzyan, K.G., 761 Haga, K., 807 Dunnett, S.B., 249 Karapetyan. T.D., 1077 Haga, T., 807 Dvolakova, L., 389 Karlsson, I.. 415 Hagberg, H., 361 Dwek, R.A., 929 Karlsson, J. -0., 415 Hakopian, V.P., 1083 Dzhandzhugazyan, K.N., 707 Karpati, E., 215 Hamberger, A., 1131 Kasahara, T., 813 Hamprecht, 8., 765 Edvardsen, K., 891 Kascheyeva, T.K., 457 Handa, S., 933 Eikelenboom, P., 15 Kast, K., 281 Hashim, A., 315 Ennis, e., 1089 Kataoka, K., 83 Haug, L.S. 389 Erdtsieck-Emste, E., 1161 Kawa, A., 295 Hayashi, N., 97 Eriksson, N.P., 549 Kawashima, K., 813 Hayashi, M.K., 807 Esfandiari, A., 751 Kendall, A.L., 249 Heider, M., 829 Evans, N., 1089 Kevorgian, G.A., 1083 Heilbronn, A., 701 Eyer, J., 227 Khvatova, E.M., 757 Heinonen, E., 331 Khyazeva, L.A., 853 Henn, e., 743 Feenstra, M., 1161 Kienzl, E., 33 Hermann, A., 733 Fellows, L.K., 561 Kinosita, K., 97 Herrmann, e., 675 Fiebich, B.L., 27 Kinugawa, H.. 91 Hertting, ·G., 843, 987 Fillenz, M., 561, 577 Kiselyov, V.V., 891 Hery, F., 63 Fischer, S., 625 Kisielevski, Y., 737, 847 Heuer, H., 691 Fishman, H.A., 1131 Kiss, B., 215 Hilberer-Ehret, S., 773 F1ogel, U., 571 Klein, J., 743 Hildebrandt, H., 885 Fox, G.B., 877 Klein, R., 28\ Hjorth, S., 201 France-Lanord, V., 259 Knollema, S., 73 79 Hogue Angeletti, R., 583 Francescangeli, E., 1029 Koczyk, D., 497 Holland, V.L., 69 Francis, P.T., 153 Koenig, E., 667 Hoppenstedt, W., 239 Filchtner, F., 1149 Kohen, R., 21 Hoveyan, G.A., 761 Fujii, T., 813 Konstantinova, N.N., 457 Hovsepian, L.M., 761 Fujimoto, K., 813 Korenevsky, A.V., 529 Huitinga, I., 105 Furukawa, K., 165 Korf, J., 401 Hull, M.,27 Fyske, E.M., 1095 Korinthenberg, R., 281 Hume, S.P., 1139 Kortje, K.-H., 395 Gaal, J., 315 Kosina, L.S., 457 Gager, T.L., 69 Izvarina, N.L., 797 Kovacs, J., 479 Author Index 1193

Krizbai, I., 479 Massaro, A.R., 451 Ohman, S., 433 Krug, M., 905 Matarredona, E.R., 309 Oja, S.S., 733, 939 Krupka-Matuszczyk, I., 1035 Mateo, J., 695 Oosterink, B.1., 351, 401 Kucia, K., 1035 Matsionis, A., 339 Oparina, T.r., 529 Kwiatkowska-Patzer, B., 137 Matsionis, A.E., 419 Oren, R., 647 Matthies, Jr., H., 905 Orensanz, L.M., 1123 La Spada, P., 1005 Mattson, M.P., 165 Orwar, 0., 1131 Lajtha, A., 315 Melkonian, K.V., 1083 Osborne, N.N., 611 Lambeng, N., 259 Melkonian, M.M., 761 Ostvold, A.C., 389 Lammertsma, A.A., 1139 Mendzeritsky, A., 339 Lammintausta, R., 331 Menez, A., 783 Pahor, V., 501 Lapidot, A., 631 Merlo, D., 357 Papini, N., 1005 Laszlovszky, I., 215 Meunier, FA, 713 Papp, M., 197 Law, R.O., 943 Mezesova, V., 375 Paronian, Z., 595 lazarewicz, J.W., 361 Michaelson, D.M., 21 Pass, I., 1089 Leclerc, N., 491 Michel, P.P., 259 Patrone, c., 523 Lee, K., 987 Mickaleva, 1.1., 757 Patumeau-Jouas, M., 751 Lehotsky, J., 375, 383 Mijanovic, M., 963 Pavlenko, A.V., 457 Leibfritz, D., 571 Mikaelyan, E.R., 1077 Pavlova, N.G., 457 Lepeohin, VA, 291 Mikhailov, A.V., 457 Pedersen, N., 857, 897 Levi, G., 541 Mikoyan, V., 977 Pellerin, L., 555 Li,J.-Y., 1101 Minghetti, L., 541 Perrone Capano. c.. 637 Lieb, K., 27 Miras-Portugal, T., 695 Persson, J.K.E .• 549 Linemann, H., 1149 Misawa, H., 813 Peter, J.B., 443 Lipkowski, A.W., 137 Mlynarik, V., 177 183 Peterson, A., 227 Liptaj, T., 177 183 Mohrmann, M., 281 Petroni, A., 1005 Litvin, S., 631 Mokrushin, A.A., 519 Pfeuffer, J., 571 Liu, L., 549 Molg6, J., 713 Piemo, S., 461 L1igoila-Trulla, L., 1053 Moret, C., 193 Plekhanov, A.Y., 519 Lobanov, N.A., 1059 Morgan, A., 719 Plesneva, S., 919 LOffelholz, K., 743 Moscho, A., 1131 Poindron, P., 485 Lohmann, K., 1117 Mroczkowska, J., 1059 Polazzi, E., 541 Lomnitski. L., 21 Murphy, KJ., 877 Polman, C.H., 121 Long, S.K., 59 Myers, R., 1139 Popova, N.K., 209 LOw,M.,215 Porcellati, S., 1029 Lowry, J.P., 577 Nagel, J.G., 141 Povilaitite, P.E., 419 Luiten, P.G.M., 147,351,401, Nakamura, F., 807 Prag, S., 897 507 Nal~cz, K.A., 1059 Prokopenko, V.M., 529 Lukacova, N., 465 Nal~cz, MJ., 1059 Puccetli, c., 1065 Lysenko, A., 339 Nalivaeva, N., 919 Puchinger, L., 33 Lysenko, A.V., 419 Naritomi, H., 91 Puka-Sundvall, M., 361 Lyzlova, L.V., 457 Narkevich, V., 977 Pylaev, A.S., 853 Nazarenko, A.V., 9 Pylae va, S.A., 853 Maar, T.E., 891 Nelson, N., 173 Machado, A., 309 Nemeth, L., 479 Racay, P., 375, 383 Maggi, A., 523 Nerini, M., 949 Raeymaekers, L., 375, 383 Magistretti, PJ., 555 Nicolini, A., 541 Rahmann, H., 395, 885, 925 Magyar, K., 303 Nielander, H.B., 1107 Ramsay, R.R., 1039 Maienschein, V., 701 Nikulina, E.M., 209 Rapelli, S., 913 Maki-Ikola, 0., 331 Nilova, N.S., 797 Raus, J., 113 Makleit, S., 215 Nowak, J.Z., 605 Rayevsky, K., 977 Malecki, A., 1035 Nyakas, c., 147,351 Regan, C.M., 877 Marangolo, M., 959 Regland, B., 415 Marchini, c., 83 O'Connell, A.W., 877 Reiber, H., 423 Marcilhac, A., 63 Obert, M., 1149 Reiter, RJ., 599 Marquette, C., 967 Oderfeld-Nowak, B., 497 Ricciardi-Castagnoli, P., 625 Marsala, J., 465 Oestreicher, A.B., 1107 Ricciolini, R., 1053, 1065 Marsala, M., 465 Oganesjan, N., 847 Richter, K., 901 Martin, R., 643, 661, 667 Ogata, T., 83 Richter-Landsberg, c., 239 1194 Author Index

Ro~ner, S., 829 Smalla, K.H., 905 Valjevac, K., 963 Robakidze, T.N., 345 Smit, A.B., 655 Van Calker, D., 535 Roberg, B., 389 Snoek, G.T., 999 Van Dam, A.-M., 967 Robillard, G.T., 773 Sokolova, T.V., 973 Van der Wal, A., 1161 Rosiak, J., 605 Soliakov, L., 801 VanderWerf, Y.D., 141 Rosner, H., 885 Soroka, V., 891 Van der lee, E.A., 507 Rosser, A.E., 249 Sottocomola, E., 913 Vandevyver, e., 113 Rotllan, P., 695 Spira, M.E., 647 Van de Witte, S.V., 73 Ruberg, M., 259 Sprouse, J., 47 Vanin, A., 977 Rump, S., 55 Srapionian, R., 595 Van Kesteren, E.R., 655 Rusina, E.I., 457 Staak, S., 905, 1071 Van Minnen, J., 655 Russell, J., 583 Steinbach, J., 1149 Van Oosten, 8.W., 121 Ruuls, S.R., 105,967 Stepanov, M.G., 529 Van Rijn, e.M., 275 Rybkowski, W., 361 Stienstra, e.M., 351,40I Van Uum, H., 1161 Stinissen, P., 113 Vardanyan, A.G., 1077 Sabala, P., 1011 Stoof, J.e., 243 Varga, V., 733 Safa, R., 611 Stuiver, 8.T., 351,40 I Vananian, G.S., 1019 Saido, T.e., 407 Stvolinsky, S.L., 177 Vegeto, E., 523 Salinska, E., 361 Sutherland, R.J., 173 Vitskova, G., 977 Salmon, E., 1145 Suzuki, T., 813 Vogel, R., 765 Sanchez-Margalet, V., 589 Svendsen, e.N., 249 Vohringer, P., 395 Sandberg, M., 1131 Svensson, M., 549 Volk, B., 27 Santagati, S., 523 Syed, N.I., 655 Volknandt, W., 675 Santiago, M., 309 Sypecka, J., 233 Volonte, e., 357 Santos-Alvarez, J., 589 Szabo, e.A., 479 Saransaari, P., 733,939 Szutowicz, A., 737, 821, 847, 993 Sargsian, A., 761 Walaas, S.I., 389 Sawada, T., 91 Tabagari, S., 1025 Wallin, A., 415 Scalibastri, M., 1053 Tajima, S., 813 Walmod, P., 295 Schachner, M., 863 Taki, T., 933 Walmod, P.S., 897 Scheller, R.H., 1131 Ter Horst, G.J., 73, 79,141 Walter, B., 1149 Schicknick, H., 1117 Thakhava, G., 1025 Waner, J.-M., 485 Schliebs, R., 829 Thomas, D.R., 69 Wassenaar, J.S., 22' Schloss, P.. 773 Tilders, F.J.H., 967 Watts, e., 249 Schmidlin, A.. 625 Tipton, K., 299 Wawrzenczyk, A., 1059 Schmidt, R., 869 Tipton, K.F., 959 Welzl, H., 863 Schoben, A., 843 Tischmeyer, W., 1117 Wiersma, A., 79 Schomburg, L., 691 Titgemeyer, F.M., 773 Wiesinger, H., 625, 765 Schotman, P., 1107 Tkac, I., 177 183 Wiktorek, M., 101\ Schousboe, A., 891 Tokarev, A.V., 797 Will,E.,1149 Willems-van Bree, E., 275 Schrama, L.H., 1107 Tomaszewicz, M., 737, 821, 847, Williams, D.e., 773, 959 Schuben, P., 83 993 Willker, W., 571 Sciarroni, A.F., 1053 Tonali, P., 451 Willner, P., 197 Seidenbecher, c., 901 Topuria, M., 1025 Wing, D.R., 929 Sellin, L.e., 713 Torgner, I., 389 Wirtz, K.W.A., 999 Serfozo, l., 733 Torzewska, D., 513 Wonnacott, S., 801 Sergutina, A.V., 161 Trzeciak, H.I., 1035 Wood, M.D., 69 Sershen, H., 315 Tsiang, H., 967 Shakarisvili, R., 1025 Tsuga, H., 807 Shelayeva, E.V., 457 Tumani, H., 443 Yamada, S., 813 Shen, G.Q., 443 Turner, A.J., 683 Yasar, S., 327 Shibuya, T., 97 Turwitt, S., 691 Yerlykina, E.I., 757 Shimizu, T., 91 Tyurin, VA, 973 Young, A.M.J., 1157 Shohami, E., 2\ Tyurina, Y.Y., 973 Yuki, N., 933 Siaud, P., 63 Sinichkin, A.A., 291 Ugane, M., 611 Sival, D.A., 475 Uskova, N.I., 419 lablocka, B., 407 Skrinskaya, J.A., 209 Utagawa, A., 97 lakharova, 1.0., 973 Skup, M., 497, 513 Uzdensky, A.B., 345 lalewska, T., 369,407 Author Index 1195

Zamfirova, R., 949 Zhang, J., 113 Zimmennann, H., 701 Zamze, S.E., 929 Zhuravin, 1.,919 Zisterer, D., 959 Zare, R.N., 1131 Zhvania, M.G., 491 Zouheiry, H., 583 Zaremba, M., 497, 513 Ziembowicz, A., 36\ Zwart, J.P.c., 275 Zawilska, 1.8., 605 Zieminska, E., 361 Zwiener, U., 1149 SUBJECT INDEX

A10 nervous system, hypothennia treatment, 102 Actin cytoskeleton, NCAM-B expressing cells, 900 Acetyl coenzyme A (acetyl CoAl, 737, 847, 993, Actinopterygian fish, ependymin mRNA, 874 1039 Activated T lymphocytes, cytokines, 130 effect of ethanol, 847 Active oxygen fonns, 798 neuropathies, 821 Acute phase proteins, 16,27 N-Acetylaspartate, 181 Acyl coenzyme A (acyl CoAl, camitine, 1040, 1047 Acetylcamitine, 822, 1053 Acylcoenzyme A (acyl CoAl dehydrogenase, 755 ischemic injury, 1048 Acylcamitine, 1040 N-Acetylcamosine, 117 Adenosine, 70 I, 732 Acetylcholine, 695, 993 effect of ethanol, 847 camitine, 1049 effect on glial cell activation, 83 diadenosine polyphosphates (ApnA), 695 microglial activation, 535 estrogen-induced differentiation, 525 release of prostaglandin E2, 535 plasma and blood, 813 Adenosine diphosphate (ADP), glutamine hydrolyse, release ofneurotransmitters, 80 I 1079 thiamine deficiency, 737 Adenosine kinases, 695 Acetylcholine esterase, 148,830 Adenosine 5'-( a,~-methylene)diphosphate, reduction anencephaly, 458 in neurite fonnation, 703 tacrine, 345 Adenosine monophosphate (AMP), effects ofadeno• Acetylcholine receptors, 648, 794, 80 I, 813 sine, 88 calcium channels, 843 Adenosine 3',5'-monophosphate (cAMP) hypertensive state, 853 catecholamines, 731 phosphorylation, 807 ceramid-induced apoptosis, 261 Acetylcholine release, 830 chromaffin cell exocytosis, 722 botulinum neurotoxins, 713 effect of gangliosides, 919 effect ofethanol, 847 glycogen resynthesis, 556 Acetylcholine synthesis, 837 Adenosine 3',5'-monophosphorothioate, 545 camitine, 1062 Adenosine receptor (PI), 357 Acetylcholinergic neurons, effect ofnerve growth fac- Adenosine receptors, 703 tor, 831 Adenosine triphosphate (ATP), 701, 707, 757, N-Acetyldehydrosphingosine, 261 1084 N-Acetyl-D-glucosamine,911 diadenosine polyphosphates (ApnA), 695 N-Acetylglucosaminidase,932 effect on platelet activation, 1032 N-Acetylhistidine, 177 hexokinase, 757 N-Acetylhomocamosine, 177 phosphatidylserine synthesis, 1011 N-Acetyl-D-mannosamine, 878 relation with NCAM, 707 N-Acetylserine, 177 thiamine deficiency, 739 Acid phosphatase activity, histamine, 479 Adenosine triphosphatase (ATPase) Aconitase, effect ofnitric oxide, 993 calcium transport, 375 ACTH: see Adrenocorticotropic honnone relation with NCAM, 707 Actin, synthesis in axons, 673 Adenylate, 695

1197 1198 Subject Index

Adenylate cyclase, 88 Alzheimer's disease (AD) (conI.) cardiac arrest and resuscitation, 729 nitric oxide (NO), 977, 993 effect ofgangliosides, 919 phospholipid metabolites, 33 Adenylyl-~,y-imidodiphosphate, 358 potassium channels, 538 Adhesion factors, 16, 27 Amacrine cells, 605, 613 Adhesion molecule on glia (AMOG), 711 serotonin and y-aminobutyric acid, 612 Adrenal chromaffin, 987 Amantadine, 102 effect of nitric oxide, 987 Aminoacyl-tRNA synthetases, in axons, 638 Adrenal chromaffin cells, exocytosis, 719 2-Aminobicyclo[2,2,I)heptane-2-carboxylic acid, ami- Adrenal cortex, stress response, 151 noacid transport, 619 Adrenal grafts, Parkinson's disease, 250 y-Aminobutyric acid (GABA), 421, 525, 529. 632 Adrenal medulla, 595 amacrine cells, 613 Parkinson's disease, 250 capillary electrophoresis patch clamp det, 1135 Adrenal medullary proteins, 595 camitine, 1049 Adrenalectomy, calcium homeostasis, 405 effect of taurine, 964 Adrenaline, chromaffin cells, 720 ethanol, 748 Adrenaline release, effect ofnitric oxide, 990 extracellular after optic nerve cut. 395 ~-Adrenergic activation, cAMP levels, 545 hypokinesia, 1083 Adrenocorticotropic hormone (ACTH), 63 inhibitory neurotransmitter, 275 Aggrecan,901 metabolic trafficking, 1069 Aging release from globus pallidus, 955 behavioral dysfunctions, 149 release from substantia nigra, 949 dysfunction ofthe respiratory chain, 751 transporters, 774 AIDS dementia, prostanoid levels, 542 uptake system, 1042 Alanine, 632 y-Aminobutyric acid receptor, 275, 834, 1123 y-aminobutyric acid receptor, 1123 alanine, 1123 taurine uptake, 959 relation with ACh-receptor, 801 ~-Alanylhistidine, and brain ischemia, 177 y-Aminobutyric acid-aspartate transaminase, calpain Albumin, 292 activity, 421 cerebrospinal fluid, 426 y-Aminobutyric acid-glutamate transaminase, calpain immunoreactivity in brain, 142 activity, 421 Albumin CSF/serum quotient, 423 I-Aminocyclopropanecarboxylic acid, 197 Albumine transport, histamine, 483 I-Aminocyclopentane-dicarboxylic acid, 734, 1071 Alcoholism, acetylcholine synthesis, 821 neuroprotection, 939 Alkaline metalloproteinase, effect on myelin basic pro- Aminoethylarsonic acid. taurine uptake, 961 tein, 1115 Aminoethylphosphonic acid, taurine uptake, 961 1-0-Alkyl-2-acetyl-sn-glycerol, 1029 Aminoguanidine, 970 I-O-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, 1029 2-Amino-3-hydroxy-5-methyl-4-isoxazolpropionate re- I-O-Alkyl-2-(longchain)acyl-sn-glycero-3-phospho- ceptors, dopamine release, 733 choline, 1030 2-Amino-3-hydroxy-5-methyl-4-isoxazolpropionate I-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine, 1030 acid (AMPA), 266, 733 Alloxan monohydrate, 632 capillary electrophoresis patch clamp, 1135 Alpha-fetoprotein 6-Aminomethyl-3-melhyl-1 ,2,4-benzothiadiazine-l, 1- anencephaly, 458 dioxide, taurine uptake, 961 estradiol requesting, 526 Aminopeptidase, 162, 163 Alpha-tocopherol, sodium, potassium-ATPase activ• Aminopropylarsonic acid, taurine uptake, 961 ity, 973 Aminoquinoline,16 Aluminum, effect on ACh-synthesis, 822 endplate potentials, 715 Alzheimer's disease (AD), 15,21,27,39,259,268 Amiridin, senile dementia of Alzheimer's type acetylcholine synthesis, 821 (SDAT),345 amiridine and tacrine, 345 Amitriptyline, 194 calcium homeostasis, 402, 415 phospholipase A2, 1035 camitine, 1049 Ammonia, 201 cerebrovascular insufficiency, 173 phosphate activated glutaminase, 1077 cortical cholinergic dysfunction, 829 Amnesia, role ofependymin, 873 ependymin, 869 AMP: see Adenosine monophosphate glutamine synthese, 443 AMPA: see Amino-3-hydroxy-5-methyl-4-isoxazol• IP3-receptor, 389 propionic acid neurotransmitter-based treatments, 153 AMPA/quisqualate receptors, epilepsy, 266 Subject Index 1199

Amphetamine, 198, 304, 315 Arginine dopamine and serotonin, 327 catecholamine release, 988 Amphetamines, monoaminergic systems, 323 transport in neural cells, 625 Amygdala, synaptic structures, 492 Aromatic aminoacid decarboxylase, 605 ~-Amyloid, 156, 345, 389, 822 Arsonoalanine, taurine uptake, 961 p-Amyloid associated proteins, 15 Aryl sulphatase, 479 p-Amyloid peptides, calcium homeostasis, 402 Ascorbate, 599 Amyloid plaques, 28 Ascorbic acid, 614 Amyloid precursor protein (APP), 27, 156,345 leech ganglia, 983 potassium channels, 536 Aspartate Amyloid precursor protein (sAPP), secreted fonn, 165 deoxyglucose uptake, 556 Amyloid-protein, 27 P2 purinoceptor, 358 Amyotrophic lateral sclerosis (ALS), 259 Astacus leptodactilus, amiridine and tacrine, 345 glutamine synthase, 444 Astrocyte culture, 502 superox ide dismutase, 485 Astrocytes, 73, 50 I Anatoxin-a, 801 5'-nucleotidase, 702 Anencephaly, creatine kinase isoenzymes, 457 aminoacid transport, 619 Angiotensin converting enzyme, 425 ecto-5'-nucleotidase, 702 Anhedonia, 198 glucose uptake, 555 Anion transport protein, 417 malic enzyme isofonns. 765 Annexin II, effect on exocytosis, 721 NGF and NGF-receptor expression, 499 Anserine, 177 Parkinson's disease, 253 Antagonist F, diacylglycerol and arachidonic acid, regulation by adenosine, 88 1019 role in neuronal metabolism, 561 Anterior hom, motor neurons, 485 study to assess the effects, 751 Anterograde degeneration, microglial reaction, 549 Astroglial cells Anthraquinone sulfonic acid derivative, 358 NO synthase, 627 Anti-epileptic phannaca, 275 trimethyltin intoxication, 499 Anti-inflammation drugs, 18 Astroglioma cells, human U373. 30 Anti-neural antibodies, Guillain-Barre syndrome, 933 ATP: see Adenosine triphosphate Antibody, to gangliosides, 282 ATP analogs, ecto-ApnA hydrolase, 698 a,-Antichymotrypsin,27 ATP receptor (P2), glutamate release, 357 Antidepressant drugs, 197 ATP-binding protein, glutamine synthetase, 443 Antimycin A, beta-oxidation activity, 752 ATP-citrate lyase, effect ofnitric oxide, 997 Antisense phosphorothioate oligodeoxynucleotides, in• ATP-utilizing ecto-enzymes, 707 hibition ofc-jun, jun B, or c-fos expression, ATPase: see Adenosinetriphospatase 1117 Atrial natriuretic peptide family, 683 Antisense intervention, jun and fos gene families, 1120 Atropine, 793 ai-Antitrypsin, 27 Autoantibodies Anxiety to central nervous system and phospholipid, 281 cholestokinin type 8 receptor, 1089 to nervous tissue antigens, 265 dopamine metabolism, 209 Autographa cali/ornica, 693 role ofserotonin (5HT), 48 Autoimmune diseases Aplysia cali/ornica, 864 nitric oxide, 542 N-CAM-related adhesion molecules, 864 prostanoid levels, 542 Aplysia neurons, 647 Autophagosomes, 341 Apolipoprotein E, 16 Autoreactive T lymphocytes, multiple sclerosis, I13 allele E4, 21 Axon injury, microglial reaction, 549 Apolipoproteins,27 Axon, gene expression, 637 Apomorphine, 215 Axonal segments Apoptosis, 300. 323 de novo protein synthesis, 649 amiridine, 346 long-tenn survival, 647 dopaminergic neurons, 259 Axonal transport, and Rab3a, 1102 Apyrase, 698, 700 Axons, long tenn survival, 647 Arachidonic acid, 37,126,1010 Axotomy, microglial reaction, 549 fenaridin and antagonist F, 1019 Axotremorine, 794 neuroprotection, 541 Arachis hypogaea agglutinin. 910 B-50: see Protein 850 Arachnoid villi, 423 Bacterial endotoxin, 541 1200 Subject Index

Baculovirus, serotonin transporter expression, 778 Brevican, hyaluronic acid-binding protein, 901 Barbiturates, 275 Bromocriptine, 334 alanine responses, 1123 Brush borders, ectopeptidase, 683 Basal nucleus of Meynert (BNM), effect of N-methyl- Bulbectomized rats, secretion ofACTH and corticos- D-aspartate, 352 terone,64 Basilen blue, 358 a-Bungarotoxin, 844 Bay k 8644, 844 Bunodosoma granulifera, dendrotoxin, 787 BcI-2 expression, 323 t-Butylbicyclo-orthobenzoate. GABA-receptor, 275 Benzodiazepines, 275 alanine responses, 1123 C-reactive-protein, 27 Bergmann glial cells, 5'-nucleotidase, 702 C6 glioma cells, NO synthase, 627 Beta-oxidation activity, mitochondrial electron trans• Cadherin superfamily, cell-cell adhesion molecules, 857 port, 752 Cadmium, dopamine release, 803 Betaine, transporters, 774 Caffeine Bicuculline leakage ofcalcium, 463 alanine responses, 1123 PI purinoceptor antagonist, 358 fos-expression after microdialysis injection, 1163 Calbindin, 169 hypokinesia, 1085 Calbindin-D28K, 832 Bicuculline-methochloride,276 Calcitonin gene related peptide, endplate potentials, Bilateral olfactory bulbectomy, effect on ACTH and 715 corticosterone, 65 Calcium, 401, 720, 926, 1083 Biogenic amines, 469 AChR-mediated dopamine release, 802 Biosensors, capillary electrophoresis, 1132 action of pancreastatin, 591 Blood, 1026 after optic nerve cut, 395 acetylcholine (ACh), 813 axonal protein synthesis, 645 Blood-brain barrier (BBB), 291, 550 axonal segments,647 aminoacid transport system /, 627 binding to ependymin, 871 aminoacid transport, 619 ecto-ApnA hydrolase, 699 catecholamines, 729 effect ofNO-donors on catecholamine release, 990 effects ofbrain temperature, 91 effects ofadenosine, 88 effect of reoxygenation, 465 effects on noradrenaline release, 843 histamine, 480 generation ofoxygen radicals, 300 in multiple sclerosis (MS), 454 intracellular store, 383 selective dysfunction, 141 mdx mouse, 461 transport of glucose, 565 phosphate activated glutaminase, 1077 transport of ketone, 634 phosphatidylserine synthesis, 1011 Blood-CSF barrier, 423 SH-SY5Y cells, 793 Boma disease, induction of NO-synthase, 968 stretch receptor neuron firing, 346 Botulinum neurotoxins, acetylcholine release, 713 transport ATPases, 708 Bradykinin, 469 Calcium binding proteins, role in homeostasis, 402 idiopathic neuralgia, 472 Calcium channel blockers, neuroprotection, 402 Brain damage, effect on reperfusion, 465 Calcium channels, 351. 802, 843 Brain disorders, positron emission tomography (PET), endplate potentials, 716 1149 Calcium homeostasis, 415 Brain injury, 83 chromogranin A, 583 nitric oxide, 993 developing neurons, 147 Brain paroxysmal activitiy, autoantibodies, 265 Calcium, intracellular Brain spectrin, 408 y-aminobutyric acid, 1083 Brain tissue temperature, 97 neuroprotective mechanisms, 401 Brain, sexual differentiation, 523 Calcium leak channels, mdx mouse, 461 Brain-derived neurotropic factor (BDNF), 507 Calcium mobilisation, cholestokinin type B receptor, Brain-derived neurotropic factor receptor (trkB), 1089 507 Calcium overload, ischemic-reperfusion injury, 375 Brain-derived proteins, 427 Calcium release, calcium-induced, 361 Brainstem, motor neurons, 485 Calcium transport, 383 BrainView program, help in equidensity lining, 1119 effect of taurine, 941 Branched-chain amino acids N-methyl·D·aspartate (NMDA) receptors, 361 camitine, 1040 Calcium transport ATP dependent, role in homeosta• transport in glial cells, 619 sis, 402 Subject Index 1201

Calcium transport ATPase, 375 Cataract, free radicals, 611 Calcium uptake, P2 purinoceptor, 358 Catechol-O-methyl transferase (COMT), 209 Calcium-activated kinases, ischemia, 369 positron emission tomography, 1153 Calcium-activated phosphatases, ischemia, 369 Cathecholamine release, 987 Calcium-binding proteins, 383 Catecholamine secreting primary neurons, 251 Calcium-channel proteins, effect ofcalpains, 408 Cathecholamine transport carrier, 316 Calcium-dependent protein kinase, 645 Catecholamines Calcium-dependent proteolysis, calpains, 407 adrenal medulla, 595 Calcium/calmodulin-dependent protein kinase, phos- cardiac arrest and resuscitation, 729 phoylation ofsynaptic proteins, 1095 effect ofxenobiotics, 529 Calmodulin, 645 effect on pancreastatin, 589 Calmodulin-dependant kinase II (CaM KII), ischemia, estrogen-induced di fferentiation, 525 369 Cathepsin B, effect on myelin basic protein, 1115 Calpain, 407 Cathepsin 0, 341 NMOA-glutamate receptors, 343 effect on myelin basic protein, 1115 Calpastatin, 407, 415 Caudate nucleus, 162, 288 Calreticulin, 376 C098 surface antigen, aminoacid transport, 622 antibodies, 384 Cell adhesion molecules, 869 cAMP: see Adenosine 3',5'-monophosphate; Cyclic carbohydrate epitope L2/HNK I, 702 AMP Cell communication, 707 Campylobacter jejuni, anti-neural antibodies, 933 Cell cycle, effect of methamphetamine, 324 Canavanine, 626 Cell movement, neural cell adhesion molecule Cancer, free radicals, 611 (NCAMl,897 Capillaries, sharply narrowed, effect ofy-aminobutyric Cell surface antigen A2B5. 239 acid, 1084 Cell-cell adhesion molecules, 857 Capillary electrophoresis, patch-clamp detection, 1133 Cell-cell adhesion, role ofNCAM, 894 Carassius carassius. effect oftemperature on gan• Cell-cell interactions, 929 gliosides, 926 neural cell adhesion molecule (NCAM), 885 Carbachol, 793, 794 Central nervous system, autoantibodies, 281 Carbohydrate epitope L2/HNK I, cell adhesion mole• Central nervous tissue factor, 513 cules, 702 Centruroides sculpturatus. toxin, 784 Carbon-II, use in positron emission tomography, Ceramides, 169 1140 in P12 cells, 260 Carbonyl cyanide m-chlorophenylhydrazone, endplate Cerebellar granule cells, ecto-5'-nucleotidase, 702 potential, 716 Cerebellar granule neurons, 357 Cardiac arrest, norepinephrine and epinephrine, 729 Cerebellum, neuroprotective effect oftaurine, 939 Cardiac ganglia, M-cholinoreception and beta-ad• Cerebral amyloid plaques, 27 renoreception, 853 Cerebral blood flow, 97, 561, 1150 Cardiolipin, 762 Cerebral blood volume, 1150 Camitine, 1039, 1053 Cerebral cortex cell function, 1047 cortical cholinergic dysfunction, 829 taurine uptake, 961 dopamine release, 733 transport in neuronal mitochondria, 1061 Cerebral ischemia Camitine acetyltransferase, 1055 magnetic resonance imaging. 184 mitochondria, 1048 mild hypothermia, 91 thiamine deficiency, 739 Cerebrosides, multiple infarct dementia, 1026 Camitine acyltransferases, 1039, 1047 Cerebrospinal fluid (CSF), 423, 433, 443 energy modulating, 1040 lipid spectrum and lysosomal enzymes, 1026 mitochondria, 1048 Cerebrovascular insufficiency, 173 Camitine octanoyl transferase, membrane formation, CG4 cell line, 239 1048 cGMP: see Guanosine monophosphate Camitine palmitoyltransferase CGP 37849, 199 energy modulating, 1040 CGP40116,I99 lipid biosynthetic pathways, 1053 Charybdotoxin, 784 membrane formation, 1048 Chelerythrine, 240, 1072 Camitine translocase, 1040 Chinese hamster ovary cell line, cholestokinin type B Camosine, brain ischemia, 177 receptor, 1089 Casein kinase II, 679 Chlordiazepoxide, 198 phosphorylation of MVPIOO, 679 Chloride-channels, 275 1202 Subject Index

N-(Chloroethyl)-N-ethyl-2-bromo-benzylamine (DSP• Concanavalin A, 910 4),299,305 Conditioning ofa neutral stimulus, effect on dopamine p-Chlorophenylalamine, 189 release, 1157 pain feeling, 473 (j)-Conotoxin,844 m-Chlorophenylpiperzine, 188 Convulsants, 275 Cholecystokinin, 1089 Convulsions, platelet-activating factor (PAF), 1029 Cholecystokinin type B receptor, 1089 Convulsive states, effect on nitric oxide, 977 Cholesterol esters, 1026 Copolymer-I, 115 Cholesterol Cortex synaptosomes, effect of glutamate on Na+,973 leech ganglia, 983 Cortical neurones, effect ofcamitine on acetylcholine multiple infarct dementia, 1026 synthesis, 1062 effect oftemperature, 926 Cortical pyramidal neurones, glutaminergic function, Choline 153 taurine uptake, 961 Corticospinal tract, 485 transport through neuronal membranes, 837 Corticosterone, 63 Choline acetyltransferase, 525, 813, 830 eicosanoid synthesis, 132 thiamine deficiency, 739 stress response, 150 Choline uptake, 830 Corticotropin-releasing honnone, 63, 1088 Cholinephosphoglycerides, 1030 Countershaping process, 222 Cholinergic nerve tenninals, 713 Crayfish, amiridine and tacrine, 345 Cholinergic neurons, nerve growth factor (NGF), 513 Creatine kinase, 457 Chondroitin sulphate, 901 Creatine kinase isoenzymes, brain development disor• Choroid plexus, 423 ders, 457 Chromaffin cells, diadenosine polyphosphates Crucian carps, effect of temperature on gangliosides, (ApnAl,695 926 Chromaffin granules, chromogranin A, 584 CSM 14.1 neurons, expression of BcI-2, 323 Chromogranin A Cyano-7-nitroquinoxaline-2, 734 pancreastatin, 589 Cyclic nucleotides: see Adenosine 3',5'·monophos• properties ofpeptides, 583 phate; Guanosine monophosphate Chromogranins, adrenal medulla, 595 Cyclic AMP dependent protein kinase A Chronic experimental hepatic encephalopathy, 20 I phosphorylation of synaptic proteins, 1095 Chronic mild stress, 198 phosphorylation ofMVPIOO, 679 Cichlid fish, extracellular calcium, 395 protein ex02, 722 Citalopram, 194, 774 Cyclic voltammetry, 24 Citrate, 740 Cyclo-oxygenase, 127,541 release from astrocytes, 1066 Cysteine proteases, 407 Citrulline, transport in neurons, 626 Cysteine, 734 Clathrin, axonal transport and Rab3a, 1102 camitine transport, 1060 Clomipramine, 194 Cystinuria, mutations in the NBAT/rBAT/D2 protein, Cloramphenicol-acetyltransferase activity, 17-beta-oes- 622 tradiol, 524 Cytidine triphosphate (CTP), effect on platelet-activat• Clostridium botulinum. neurotoxins, 713 ing factor, 1032 Clozapine, N-acetyltransferase, 607 Cytidine monophosphate (CMP), degradation ofplate- Clusterin, 16 let-act 1030 Cocaine, 329, 774 Cytidine diphosphocholine (CDPcholine), 1029 Cocaine analogues, use in positron emission tomogra• Cytochalasin D, 295 phy, 1146 Cytochrome c oxidase, 753 Coenzyme A: see Acetyl coenzyme A; Acyl coen- Cytofluorimetric scanning, axonal transport studies, zyme A 1102 Cognitive functions, n-3 fanyacids, 132 Cytokine synthesis, microglial activation, 535 Colony-stimulating factor, 535 Cytokines, 129, 142 Complement, mediated neurotoxocity, 17 in Alzheimer's disease, 27 Complement proteins, 16 multiple sclerosis, 121 Complement receptor, 3 Cytosine Arabinoside C, microglia, 551 microglial cells, 550 Cytoskeletal proteins, effect ofcalpains, 408 Complement receptors, 17 Cytoskeleton organization, camitine, 1056 Complement system, nervous system, 550 Cytosolic hydrolases, 695 Complement-regulatory protein, 90I COMT: see Catechol-O-methyl transferase Dantrolene, 363 Subject Index 1203

DARPP-32,390 L-Dihydroxyphenylalanine (L-Dopa), 161, 250, 331 Deferoxamine, 614 Dimethyl sulfoxide (DMSO), 173 Degeneration, regulation ofneuronal function by astro• N,N-Dimethyltaurine, taurine uptake, 961 cytes, 501 6,7-Dinitroquinoxaline-2,3-dione (DNQX), 734 Degenerative diseases, nitric oxide, 542 taurine and GABA, 956 Delta-sleep inducing peptide (DSIP), 287 taurine release, 950 calpain activity, 419 Dioxane, 529 hypokinesia, 339 Discopyge ommata, 70 I hypoxia, 757 Distal motor latency, sciatic nerve, 487 phospholipids, 761 Dithio-bis-2-nitrobenzoate, 734 Dementia, neuroprotective agents, 40 I Dithiothreitol,734 Demyelination, role of nitric oxide, 969 Dizocilpine. 197, 734 Dendrotoxin, 787 5HT IA receptor binding, 55 Dentate granule cells, 497 DL-2-amino-5-phosphonovalerate, 734 2-Deoxy-D-galactose, long-tenn potentiation, 905 DM-20 protein, PLP molecule variant, 234 Deoxyglucose DMPP, 844 marker of glucose utilization, 556 DNA damage, 324 nerve tenninals, 1161 effect of methamphetamine, 324 Deprenyl, 315 DNA polymerase a, 695 dopamine, 303, 327 DNA, of neostratial cells, 391 monoamine oxidase-B inhibitor, 299 DNA-RNA network, 223 neuroprotective effect, 79 DNQX: see 6,7-Dinitroquinoxaline-2,3-dione use in positron emission tomography, 1147 Docosahexaenoic acid, 126 Depression, 197 Domperidone, 336 5-hydroxytryptamine, 187 L-Dopa: see L-Dihydroxyphenylalanine monoamine hypothesis, 47 L-Dopa decarboxylase, positron emission tomography, noradrenaline, 193 1153 phospholipase A2, 1035 Dopamine,209,215,605,774 role of serotonin (5HT), 48 antidepressant drugs, 197 serotonin, 193 cardiac arrest and resuscitation, 729 Desferrioxamine, MPP·-induced dopaminergic toxic• estrogen-induced differentiation, 525 ity, 309 fos-expression after microdialysis injection, 1162 Desipramine, 305, 774 hypothennia treatment, 102 effect on ACTH and corticosterone, 64 methamphetamine, 323, 327 L-Desmethyldeprenyl, 315 microdial'ysis measurement, 1159 Developing neurons, hypoxia and ischemia, 147 positron emission tomography (PET), 1149 Development selegiline, 331 motor behavior, 475 transporters, 774 regulation of neuronal function by astrocytes, 50 I Dopamine cells, transplantation, 249 2,6-Di-t-butyl-1 .4-benzohydroquinone, 387 Dopamine delivery systems, Parkinson's disease, 250 Diabetes mellitus Dopamine metabolism, mental diseases, 161 acetylcholine synthesis, 821 Dopamine neurotransmission, glutathione, 246 cholinergic activity, 825 Dopamine receptor agonists, effects of light, 606 creatine kinase, 457 Dopamine receptors, 199,209 glucose in brain, 632 positron emission tomography, 1145 Diacylglycerol, 591 Dopamine release fenaridin and antagonist F, 1019 effect of rewarding stimuli, 1157 pancreastatin, 591 ionic basis of AChR mediation, 802 Diadenosine polyphosphates (ApnA), 695, 701 ionotropic glutamate receptors, 733 Dialysis encephalopathy, acetylcholine synthesis, 82 J nicotinic agonist, 802 3.4-Diaminopyridine, endplate potentials, 716 Dopamine system Dibutyryl cyclic AMP, 260 morphochemical plasticity, 161 Dicryostelium discoideum, major vault protein, 679 positron emission tomography, 1142 Diethyldithiocarbamate, 978 Dopamine-p-hydroxylase, 595 Dihydroalprenolol, 855 Dopaminergic neurons, 259, 324 5,6-Dihydrohydroxytryptamine, pain feeling, 472 glutathione, 245 Dihydro-p-erythroidine, dopamine release, 802 Dopaminergic nigrostriatal neurons, 3J2 Dihydroxyphenylacetic acid (DOPAC), 209, 216 Down's syndrome, 417 microdialysis measurement, 1159 Drug abuse, neurotransmitter transporters, 773 1204 Subject Index

DSIP: see Delta-sleep inducing peptide Endothelial cells, 479 DSP-4, 315; see also N-(chloroethyl)-N-ethyl-2• aminoacid transport, 619 bromo-benzylamine diadenosine polyphosphates (ApnA), 695 effect of (-)deprenyl, 305 ecto-5'-nucleotidase, 702 Duchenne muscular dystrophy, role ofcalcium, 461 Endotheliallysosomes, histamine, 479 Dynamin, phosphorylation ofproteins, 1095 Endothelin converting enzyme mRNA, 686 Dyskinesias, selegiline, 332 Endothelin converting enzyme, 685 Dystrophin, role ofcalcium, 461 Endothelin peptide family, endopeptidase 24.11, 685 EAE: see Experimental allergic encephalomyelitis or Endplate potential, 714 Experimental autoimmune encephalomyelitis Energy metabolism, 739 Ecto-5'-nucleotidase, neuritic differentiation and neu- catecholamines, 729 ron survival, 70 1 Energy substrate, astrocytes, 555 Ecto-ApnA hydrolase, 696 Enkephalinase, endopeptidase 24.11, 684 Ecto-apyrase, 705 Enzyme immunoassay Ecto-ATP diphosphohydrolase, ecto-nucleotidases, ofglutamine synthese, 444 700 ofnerve growth factor, 502 Ecto-ATPase, neural differentiation, 705 Ependymin mRNA, 871 Ectoenzyme, degradation of thyrotropin-releasing hor- Ependymin, memory formation, 870 mone,692 Epidermal growth factor, 90 I Ectoenzymes, 683 Epilepsy, 287 Ectopeptidase, central nervous system, 683 autoantibodies, 265 EDl positive macrophages, NO and NO synthase in immunological abnormalities, induced by oxygen, EAE,969 291 Effect ofnitric oxide, 993 neuroprotective agents, 40 I Egg-laying hormone, translation of the mRNA, neuroprotective effect of taurine, 939 656 nitric oxide (NO), 977 Eicosanoids, 127, fenaridin and antagonist F, 1019 penicillin-induced,287 Eicosaptentaenoic acid, 126 Epileptogenesis, effect on nitric acid, 980 Electric organ, vault proteins, 675 Epinephrine, cardiac arrest and resuscitation, 729 Electric ray, ecto-5'-nucleotidase, 701 EPP: see Endplate potential Electrochemical detection, biogenic amines, 530 Erythrocytes, calpastatin activity, 415 Electron microscopy (EM), 466 Escherichia coli. serotonin transporter expression, 775 brevican localization, 904 Essential fatty acids, 126 extracellular calcium, 395 Estradiol ofmRNA in axons, 657 TRH-degrading ectoenzyme, 692 ribosomes in axons, 667 SK-ER3 cells, 524 transfer of proteins to axons, 65\ Estrogen receptor antagonists, SK-ER3 cells, 524 Electron paramagnetic resonance (EPR), nitric oxide Estrogen receptor, neural cells, 523 complex, 978 Estrogens, neuroblastoma cell line, 523 Electron spectroscopic imaging (ESI) Ethanol visualization ofribosomes, 661 acetylcholine release, 743 axonal ribosomes, 667 effect on ACh release, 826 Eliprodil,197 effect on cholinergic mechanism, 847 Encapsulated cell lines, 252 Ethanolamine O-sulfoether, glutamine hydrolysis, 1077 Encephalopathies, nitric oxide, 993 Ethanolamine plasmalogens, effect of reoxygenation, Endogenous opioids, 469 465 role in pain feeling, 472 Ethanolamine, glutamine hydrolysis, 1077 Endoneuraminidase, 864 N-Ethylmaleimide-sensitive fusion protein, exocy- Endopeptidase 24.11, endothelin converting enzyme, tosis,723 685 2-(Ethylthio)-apomorphine, 215 Endoplasmic reticulum, 383 Eugerres plumieri. 396 in axonal segments, 659 Evan's blue,labelled albumin, 480 inositol triphosphate and glutaminase, 389 Excitation-contraction coupling, calcium release and inositol-triphosphate, 390 reuptake, 461 phosphatidylserine synthesis, )0II Excitatory amino acids, nimodipine and 8-0H-DPAT, synthesis of phosphatidylinositol, 999 351 Endoproteinases, myelin basic protein, I1II Excitatory amino-acid, neurodegeneration, 155 Endorphines, eicosanoids, 1019 Exo I protein, exocytosis, 722 Subject Index 1205

Ex02 protein, exocytosis, 722 Fluvoxamine, 194 Exocytosis, proteins involved, 719 Focal potential amplitudes, 519 Experimental allergic encephalomyelitis (EAE), 105, 113 Fodrin, 408, 410 by prostaglandin E2, 542 Foetal disturbances, creatine kinase isoenzymes, 457 cytokines, 121 Footshock-motivated brightness discrimination, role n-3 fally acids, 131 of transcription factors, 1117 induction ofNO-synthase, 968 Formaldehyde, 529 Experimental autoimmune encephalomyelitis (EAE), Forskolin, adenylate cyclase, 921 suppression by spinal cord protein hydrolysate, Fos protein, expression after microdialysis ofdrugs, 137 1162 Experimental epilepsy, 287 Fos- and Jun-containing transcription factors, 1121 Extensor digitorum longus (EDL), calcium release and Fos-like immunoreactivity, expression after microdia- reuptake, 461 lysis of drugs, 1162 Extracellular glucose, measurement with biosensor, Free fatty acids, multiple infarct dementia, 1026 577 Free radical hypothesis, Parkinson's disease, 244 Extracellular matrix, proteoglycans, 90 I Free radical oxidation, 530 Extrapyramidal structures, synaptic structures after hy• Free radicals, 17,309,375 pokinesia, 491 melatonin, 611 methamphetamine, 323 FI: see Protein B50 Frontal conex, 5-hydroxytryptamine, 189 FI, neurite outgrowth and regeneration, 1107 1,6-Fructose diphosphate (FDP), 173 Factors M31 and M41, neurohormones, 596 Fucose, long-term potentiation, 905 : FADH 2 see Flavin adenine dinucleotide 2'-Fucosyllactose, long-term potentiation, 905 Fally acid beta-oxidation, astrocytes, 751 Fatty acid homeostatis, retinoic acid, 1005 G protein, pancreastatin, 591 Fally acid residues, 798 G protein-coupled receptor kinases, phosphorylation Fally acids, 574 ofACh-receptor, 807 in Alzheimer's disease, 33 G protein-coupled receptor mechanism, chromogranin Fenaridin, 1019 A,585 Fenfluramine, 188 G protein-coupled receptors, 72, 792 Fentanyl, diacylglycerol and arachidonic acid, 1019 G proteins, 807 Ferritin, oxygen convulsions, 292 G proteins, 797, 798, 807 Ferrous chloride, free radicals in leech ganglia, 983 GABA: see y-Aminobutyric acid Fetal motor behavior, during development, 475 GABA-transaminase,278 F2hc surface antigen, aminoacid transpon, 620 Galactocerebroside, 235, 239 Fibroblasts Galactosidase, 479 Parkinson's disease, 253 multiple infarct dementia, 1026 spectrin degeneration, 417 Gamma-glutamyltranspeptidase,244 Fibronectin, effect on 5'-nucleotidase, 703 Gamma-glutamylcysteine synthetase, 244 Fish, N-CAM-related adhesion molecules, 864 Ganglion nodosum, M-cholinoreception and beta-ad• Fisher syndrome, anti-neural antibodies, 936 renoreception, 853

Flavin adenine dinucleotide (FADH 2), beta-oxidation Ganglioside GM I, 975 activity, 751 Gangliosides Fluorine-I 8, use in positron emission tomography, adenylate cyclase system, 920 1140 calcium dependent proteolytic activity, 417 pFluoro-amphetamine, 317 effect oftemperature, 925 Fluoro-2-deoxyglucose, uncoupling from oxygen con- meningiomas, 913 sumption, 559 sodium, potassium-ATPase activity, 973 pFluorodeprenyl,316 GAP43: see Protein B50 pFluorodesmethyl-deprenyl,317 Gastric secretion, effect on pancreastatin, 589 Fluoro-dihydroxyphenylalanine, positron emission to- Gastrocnemius muscle, 486 mography, 1149 Gene BcI-2 expression, 323 Fluorodopa, use in positron emission tomography, Gene expression 1142,1145 camitine, 1056 pFluorometamphetamine, 317 in axons, 638 5'-Fluorosulphonylbenzoyl adenosine, 708 Gene transfer, Parkinson's disease, 253 Fluoxetine, 194, 774 Gerbil forebrain, calcium-homeostasis, 383 effect on ACTH and conicosterone, 64 Gerbils, 376 interaction with selegiline, 336 GFAP: see Gliallibrillary acidic protein 1206 Subject Index

Glia cells, malic enzyme isoforms, 765 Glutamine Glial cell progenitors, 239 flux ITom neurons, 1066 Glial cells, 83, 389, 619 trafficking in fetal brain, 631 aminoacid transport, 619 Glutamine synthetase, 443, 631 effect ofadenosine, 83 cerebrospinal fluid, 430 Glial fibrillary acidic protein (GFAP), 73, 83, 239, enzyme-linked immunoassay, 444 390,498,549 Glutamylcysteine, 734 in multiple sclerosis, 451 Glutathione (GSH) Glioma (Bul7 and C6), 685 dopamine release, 733 Glioma C6 cells, phosphatidylserine synthesis, 1012 dopaminergic neurons, 245 Glioma cells, lipid metabolism, 572 melatonin, 602 Glioma x neuroblastoma hybrid cell line 108CC15, 626 Parkinson's disease, 243 Gliosis, inositol-triphosphate and glutaminase, 390 Glutathione peroxidase, 244, 983 Globus pallidus, taurine and GABA release, 955 melatonin, 602 Glucocorticoids, calcium homeostasis, 405 Glutathione S-transferase, 244 Glucocorticosteroids, eicosanoid synthesis, 132 serotonine transporters, 774 Glucose biosensor, brain extracellular concentration, Glycerol,574 577 Glycine, 733 Glucose metabolism transporters, 774 pancreastatin receptors, 590 Glycine receptor under acute osmotic stress, 573 alanine, 1123 Glucose oxidase electrode, 564 relation with ACh-receptor, 801 Glucose, 821 Glycoconjugates (38 and 104 KD), nucleo-cytoplas• astrocytes, 555 mic relation, 911 energy for neuronal metabolism, 561 Glycogen, 926 measurement with biosensor, 577 energy reserve ofbrain, 555 trafficking in fetal brain, 631 Glycogenphosphorylase, 597 Glucose-6-phosphate, hexokinase, 757 Glycoproteins, long-term potentiation, 905 Glucose-N-acetyl transferase, meningiomas, 915 Glycoproteins gpllO and gpl 16, 929 Glucosidase, multiple infarct dementia, 1026 Glycosaminoglycan, 901 Glutamate, 375, 525 Glycosphingolipids, effect oftemperature, 925 capillary electrophoresis patch clamp, 1135 meningiomas, 913 deoxyglucose uptake, 556 Glycosylphosphatidylinositol, 683 effect of taurine, 964 Glycosyltransferase, 913, 914 flux from glia to neurons, 1066 GM I ganglioside, similarity with lipopolysaccharides fos-expression after microdialysis injection, 1163 of C. jejuni, 933 neurodegeneration, 155 Goldfish nitric oxide (NO), 977 ependymin genes, 870 release of neurotransmitters from, 801 retinal ganglion cells, 870 sodium, potassium-ATPase activity, 973 Gonadoliberin, effect of xenobiotics, 529 trafficking in fetal brain, 631 Good laboratory practice, 436 Glutamate binding proteins, 267 Gpp[NH)p, adenylate cyclase, 921

Glutamate decarboxylase (GAD), 421,525,631 GR 127935, 5HT ID receptor antagonist, 62 Glutamate dehydrogenase (GDH), 390,1078 GR 46611, 5HTID receptor agonist, 62 Glutamate receptor Graded postischemic reoxygenation (GPIR), 465 antibodies, 283 Growth-associated protein GAP43: see Protein B50 antidepressant drugs, 197 GTP-binding proteins, pancreastatin receptors, 590 Glutamate receptor antagonists, 556 Guanosine, 705 Glutamate receptors, 88, 153,421 Guanosine monophosphate (cGMP) calcium transport, 361 APP-mediated neuroprotection, 166 paroxysmal activity, 266 pancreastatin, 591 retina cells, 612 Guanosinetriphosphatase (GTPase), 798 Glutamate release, P2 purinoceptor, 357 Guillain-Barre syndrome, anti-neural antibodies, Glutamate-glutamine cycle, 631 933 Glutamatergic function, in Alzheimer's disease, 153 Glutamatergic neurotransmission, dopamine release, Haemopis sanguisuga. reactive oxygen species, 984 733 Haloperidol, 161 Glutaminase, 154,631,1077 Head injury neurons, 390 cIosed,21 Subject Index 1207

Head injury (cont.) Hydroxybutyrate, 825 dimethyl sulfoxide (DMSO) and 1,6-fructose diabetic rabbit brains, 633 diphospate (FOP), 173 8-Hydroxydipropylaminotetralin (8-0H-DPAT), 188 hypothermia therapy, 97 calcium homeostatis, 404 mild hypothermia therapy, 91 NMDA-induced neurodegeneration, 352 Heat shock protein 72, 142 6-Hydroxydopamine (6-0HDA), 245, 250, 299, 312 Helper T cells, n-3 fatty acids, 131 5-Hydroxyindole-3-acetic acid (5-HIAA), 203, 216, Hemolytic disease, creatine kinase, 457 601,733 Heparan sulphate proteoglycans, 16 microdialysis measurement, 1159 Hepatic encephalopathy, 201 Hydroxyindole-O-methyltransferase, 605 glutamine synthetase, 443 Hydroxyl radicals, 309 taurine ernux, 944 effect on melatonin, 599 Hepatic necrosis, n-3 fatty acids, 133 5-Hydroxytryptamine (5-HT), 193, 20 I, 773; see also Heroin, MPTP contamination, 332 Serotonin Herpes simplex, induction of NO-synthase, 968 depression, 187 Hexokinase, delta-sleep inducing peptide, 757 Hyperalbuminization, of pituitary tissue at oxygen con- Hexosaminidase, 932 vulsion, 292 N-2-Hexyl-N-methylpropargylamine, 307 Hyperammonaemia, taurine effiux, 944 5HIAA: see 5-Hydroxyindoleacetic acid Hyperbaric oxygenation, 291 Hippocampal CA I region, long-term potentiation, Hyperosmolality, taurine biosynthesis, 944 905 Hypertensive state, 853 Hippocampal long-term potentiation, platelet-activat• Hypoglossal nerve, microglial reaction, 549 ing factor, 1029 Hypokinesia Hippocampal slices, 1071 y-aminobutyric acid, 1083 phosphatidylethanol, 744 delta-sleep inducing peptide (DSIP), 339 Hippocampus, 61,149,189,497,702,801,863,939 synaptic structures, 491 cholinergic and serotonergic innervation, 149 Hypokinetic stress 5-hydroxytryptamine, 61, 189 delta-sleep inducing peptide (DSI P), 339 neuroprotective effect of taurine, 939 synaptic structures, 492 NGF-expression in astrocytes, 497 Hypomyelination, 234, 235 5'-nucleotidase, 702 Hypo-osmolality, release of taurine, 944 release of neurotransmitters, 80 I Hypothalamic circadian rythm, xenobiotics (dioxane, Hippocampus CA3, brevican immunostaining, 903 formaldedehyde), 529 Histamine, acid phosphatase activity, 479 Hypothalamic neurohormones, 595 Histamine receptors, 483 Hypothalamic-pituitary-adrenal (HPA) axis, 63 Histology image analysis, ofprotein kinase C, acetyl- 5-hydroxytryptaminefunction, 188 choline receptors and trkS, 509 Hypothalamo-pituitary-adrenocortical axis, n-3 fatty Histone acetylation, camitine, 1056 acids. 131 Homoanserine, 177 Hypothalamus, effect of xenobiotics, 529 Homocamosine, 177 Hypothermia therapy Homovanillic acid (HV A), 209, 216 human head injury, 97 microdialysis measurement, 1159 in human acute embolic stroke. 92 Hormones, eicosanoids, 1019 in human head injury, 91 HPC-I: see Syntaxin Hypoxia 5-HT: see Serotonin calpain activity, 419, 421 Huntington's disease, 259 camitine palmitoyltransferase, 1055 nitric oxide, 823, 993 catecholamines, 729 HV A: see Homovanillic acid delta-sleep inducing peptide, 757 12-Hyaluronic, 90 I developing neurons, 147 5-Hydroeicostetraenoic acid (12HETE), 1022 neuronal lactate, 566 Hydroeicostetraenoic acid (5HETE), 1022 neuroprotective agents, 402 Hydrogen peroxide, 133, 312, 983 neuroprotective effect of taurine, 939 free radicals in leech ganglia, 983 nimodipine and 8-DH-DPAT, 351 n-3 fatty acids, 133 protective pretreatments, 79 Hydroxy radical scavenger, melatonin, 611 transient, 73 12-Hydroxy-5,8,10-heptadecatrienoic acid (HHT), 1022 ICI-182, 780 I I-Hydroxy-N-n-propylnorapomorphine, 215 SK-ER3 cells, 524 Hydroxyalkenals, 600 Idiopathic neuralgia, 469 1208 Subject Index

IgG Interferon-p, 115 cerebrospinal fluid, 426, 440 Interferon-y, 121 immunoreactivity in brain, 142 arginine transport, 625 IgG-index, cerebrospinal fluid, 440 balance between prostanoids and NO, 544 IgM, cerebrospinal fluid, 426, 434 n-3 fatty acids, 13\ Imipramine, 194,774 Interleukin-l (fL-I), 27, 121 phospholipase A2, 1035 effect on nerve growth factor, 501 Immediate early genes n-3 fatty acids, 131 c-jun, jun B, and c-fos, 1117 Interleukin-3 (fL-3), 535 expression of fos protein, 1161 Interleukin-4 (IL-4), 121 Immortalised cell lines, Parkinson's disease, 255 Interleukin-6 (fL-6), 27 Immune cells, 130 Interleukin-IO (IL-I 0), 12\ Immune system, n-3 polyunsaturated fatty acids, 125 Intermediate filament protein, vimentin, 239 Immunoblot analysis, proteins of neostratum, 390 Interplexifonn cells, 605 Immunocytochemistry, GFAP and NGF, 498 Ion channels, axonal segments, 649 Immunoglobulin (Ig) superfamily, 863, 891 Ion pumps, in axonal segments, 649 cell-cell adhesion molecules, 857 lonotropic glutamate receptors, 733 Immunoglobulin-like domains, neural cell adhesion IP3: see Inositol triphosphate molecule, 891 IP3-receptor, Alzheimer's disease (AD), 389 Immunohistochemical staining, expression of fos pro• Ipsapirone, calcium homeostasis, 404 tein, 1\61 Iron, 309 Immunological reactions, interleukin-I (IL-I), 50 I Iron chelator, MPP+-induced dopaminergic toxicity, 309 Immunotoxin 192lgG-saporin, effect on cholinergic Ischemia function, 830 calcium-homeostasis, 383 Inennediate filament proteins, 227 calmodulin-dependant kinase II, 370 Infarction, NGF-release, 513 calpain activation, 407 Infection carnitine palmitoyltransferase, \055 microglial activation, 535 catecholamines, 729 prostanoid levels, 542 developing neurons, 147 Inflammation, 17 effect on phospholipids, 465 interleukin-I (IL-I), 50 I free radicals, 611 prostanoid levels, 542 melatonin, 616 related proteins, 18 neuroprotective agents, 402 Inherited pyruvate dehydrogenase deficiencies, acetyl• neuroprotective effect of taurine, 939 choline synthesis, 821 nimodipine and 8-0H-DPAT, 35\ Injury platelet-activating factor (PAF), 1029 interleukin-I (fL-l), 50 I protective pretreatments, 79 microglial activation, 535 study by MRI methods, \83 Inonophore A23187, 1012 transient, 73 Inosine, 705 Ischemic injury Inositol, 591 acetylcarnitine, 1048 Inositol phosphate production, 830 sodium, potassium-ATPase activity, 973 Inositol triphosphate (IP3) Ischemic insult, glutamine synthetase, 443 calcium homeostasis, 402 Ischemic-reperfusion injury, InsP3 receptor and cal- neurons, 389 cium transport, 375 Inositol triphosphate-receptor (IP3-R), 376, 383, 389 lsethionic acid, taurine uptake, 961 Insomnia, selegiline, 333 Isoleucine, aminoacid transport, 622 Insulin B chain, degrading activity, 684 Isoprenaline, 565 Insulin, estrogen receptors, 525 Isoproterenol, cAMP levels, 545 Insulin-like growth factor I (IGF-I), estrogen receptors, 525 Isovalerylcarnitine, calcium dependent proteolytic ac• Insult, glutamine synthetase, 443 tivity, 417 Integrin (CR3), 109 JL-18 Integrin (VLA-4), 109 N-acetyltransferase, 608 Integrin family, cell-cell adhesion molecules, 857 Integrin receptor, 551 Kainic acid Interaction between neurons, 5'-nucleotidase, 703 CAM kinase II, 373 Intercellular adhesion molecule-I (ICAM-I), 27, \22 dopamine release, 733 Interfacing process, 222 melatonin, 600 Interferon, 536 taurine and GABA release, 949, 955 Subject Index 1209

Ketanserin, 70 Long-chain acylcamitine, membrane repair, 1040 a-Ketoglutarate, 631 Long-chain acylcamitine transferases, mitochondrial membrane, 1054 L 929 cell line, screening toxicity, 295 Long-chain fatty acids, camitine, 1040 L-365,260 Long-term potentiation (LTP), 507, 797 cholestokinin type 8 receptor, 1089 effect of2'fucosyllactose, 905 L-740,093 of brain polypeptides, 519 cholestokinin type 8 receptor, 1089 polysialic acid associated with NCAM 864 L2/HNK-I carbohydrate epitope, neuron-cell adhesion role of NCAM, 881 molecule 929 Long-term potentiation, phospholipase A2, 1038 Lactate dehydrogenase (LDH), isoenzymes, 557 Long-term survival, axons and axonal segments, 647 Lactate, 181 Lumbar ganglia, M-cholinoreception and beta-ad- effect of glutamate release, 567 renoreception, 853 energy for neuronal metabolism, 561 Lung resistance-related protein, 675 extracellular glucose, 557 Luteinizing hormone (LH), hypothermia treatment, 102 metabolic trafficking, 1070 Lymnaea stagnalis, translation in isolated axons, 655 trafficking in brain, 632 Lymphocytes Laminin/nidogen complex, effect on 5'-nucleotidase, acetylcholine receptors, 813 703 calpain activity, 416 Lazabemide, 80 n-3 fatty acids, 131 Leaming, role of transcription factors, 1117 Lymphotoxin, 121 Lectin-binding capacity, nuclear glycoproteins, 910 Lysine Leech, reactive oxygen species, 983 aminoacid transport, 622 Leiurus quinquestriatus hebreus, charybdotoxin, 784 transport in neurons, 626 Leucine, aminoacid transport, 622 LysoPAF acetyltransferase, 1030 Leukemic T-cell line, acetylcholine receptors, 813 Lysophosphatidylcholine, multiple infarct dementia, Leukocytes, selectin family, 929 1026 ), Leukotriene A4 (LTA4 1022 Lysophospholipid acyltransferase, 1041 ), Leukotriene 8 4 (LT84 1022 Lysosomal enzymes, multiple infarct dementia, 1026 proinflammatory agent, 129 Lysosomal membranes, 341 Leukotriene, 130 Lysosomal proteinases, 343 Leukotrienes, 127, 130 Lysosomes, histamine, 479 Light microscopy, 466 Limbic structures Macrophage depletion adenylate cyclase, 919 microglia cells, 106 synaptic structures after hypokinesia, 491 T cell-induced EAE, 106 a-Linolenic acid, 126 Macrophage-specific markers, microglial cells, 549 Lipid biosynthetic pathways, camitine system, 1053 Macrophages Lipid metabolism, osmotic stress, 571 cytokines, 130 Lipid peroxidation, 797 ED2+ perivascular, 107 6-hydroxymelatonin, 600 experimental allergic encephalomyelitis (EAE), 105 convulsive states, 977 Magnesium delta-sleep inducing peptide (DSIP), 339 ecto-ApnA hydrolase, 699 leech ganglia, 983 phosphatidylserine synthesis, 1011 melatonin, 600, 614 transport ATPases, 708 Lipid spectrum, multiple infarct dementia, 1026 Magnetic resonance imaging (MRI), 117, 122,440 Lipogenic acetyl-CoA, camitine, 1056 of ischemia, 183 Lipopolysaccharide (LPS) Magnocellular basal nucleus, calcium homeostasis, 402 arginine transport, 625 Magnocellular neurons, brevican immunostaining, 903 cytokine production, 536 Main pelvic ganglion, M-cholinoreception and beta-ad- melatonin, 601 renoreception, 853 mRNA expression of K+-channels, 538 Major vault protein (MVPloo), torpedo electric organ, prostanoids, 543 677 tumor necrosis factors, 536 Malate, 739 Lipopolysaccharides (LPS) of C. jejuni, similarity release from astrocytes, 1066 with GM I-ganglioside, 933 Malate dehydrogenase, delta-sleep inducing peptide, Lipoxygenase, 127 757 Liver membranes, pancreastatin receptors, 590 Malate: NADP oxidoreductase (decarboxylating), 765 Locus coeruleus, 243 Malic enzyme, isoforms, 765 1210 Subject Index

Malondialdehyde, 600 N-Methyl-D-aspartic acid (NMDA), 733 Malonyl coenzyme A (Malonyl CoAl, 1050 capillary electrophoresis patch clamp, 1135 Malonyl-CoA-sensitive acyltransferase, energy modu- N-Methyl-D,L-aspartic acid (NMDLA), 978 lating, 1040 N-Methyl-D-aspartate antagonists, 197 Maltose binding protein, 891 N-Methyl-D-aspartate receptor channels, 401 Mammalian proteins (Kell and Pex), endothelin con- N-Methyl-D-aspartate receptors, 832, 941 verting enzyme, 687 calcium transport, 34 Manganese, ecto-ApnA hydrolase, 699 dopamine release, 733 MAO: see monoamine oxydase effect ofnimodipine, 351 MAP kinase: see Mitogen-activated protein kinase in learning and memory processes, 153 Mauthner cell axoplasm, presence of RNA, 668 5-Methyl-1 0, II-dihydro-5H-dibenzo(a\d)cyclohepten• Mauthner cell axon, ribosomes, 667 5,10-imine: see Dizocilpine Mdx mouse, role ofcalcium, 461 a,~-Methylene adenosine 5'-diphosphate, ecto-nu- Mealworm, carnitine, 1039 c1eotidases, 700 Mecamylamine, dopamine release, 802 Methylenedioxy-N-n-propylnorapomorphine, 215 Medial eminence of hypothalamus, effect ofxenobi• N-Methyl-D-glucamine, 802 otics, 529 Methyllycaconitine, dopamine release, 802 Median eminence, axonal ribosomes, 664 8-Methyl-6-(4-methyl-I-piperazinyl)-11 H-pyrido[2,3- Mediodorsal nucleus of thalamus, injection ofdrugs b)[l,4)benzodiazepine, N-acetyltransferase, 608 by microdialysis, 1162 I-Methyl-4-phenyl-I,2,3,6-tetrahydropyridine Melatonin (MPTP), 246, 301, 303, 332 neural antioxidant, 599 effect of iron chelators, 309 retinal cells, 611 I-Methyl-4-phenyl-2,3-dihydropyridine, effect of iron synthesis in the retina, 605 chelators, 309 Membrane fluidity, n-3 fatty acids, 132 I-Methyl-4-phenylpyridine (MPP\ 299, 303 Membrane-associated enzymes, n-3 fatty acids, 132 effect of iron chelators, 309 Membrane-associated proteins, effect ofcalpains, 408 Methylpiperidinyl benzilate, 794 Memory formation Methysergide, 70 neural cell adhesion molecule (NCAM), 878 MGluRI-8: see Metabotropic glutamate receptors role of transcription factors, 1117 Mianserin, 70 Memory retention, effect on pancreastatin, 589 phospholipase A2, 1035 Memory, platelet-activating factor (PAF), 1029 Microdialysis Meningiomas, glycosyltransferase activities, 913 5HT analyses, 59 Mental illness, neurotransmitter transporters, 773 acetylcholine and ethanol, 744 MEPP: see Miniature endplate potential brain extracellular concentration, 577 Messenger RNA (mRNA) calcium transport, 362 alanine expression, 1129 dopamine metabolism, 1158 axonal protein synthesis, 644 extracellular glucose concentration, 562 choline acetyltransferase, 817 injection of noradrenaline or dopamine, 1162 in axons, 667 serotonin metabolites, 202 L-amino acid transporter, 620 Microglial activation translation in axons, 655 adenosine, 535 Messenger RNA expression cytokine synthesis, 535 in axons, 638 potassium, 535 ofoutward rectifying K+-channels, 537 Microglial cells, 73, 453 Mesulergine, 70 macrophage depletion, 106 Metabolic trafficking nerve injury, 550 dopamine, 209 neurotox icity and neuroprotection, 541 glucose, 555 NO and NO synthase in EAE, 969 glucose and lactate, 561 NO synthase, 627 lipids, 571 phagocytose of disintegrated neuroplasm, 55\ Metabotropic glutamate receptors, 733 prostanoids, 543 phosphorylation of brain proteins, 1071 regulation by adenosine, 88 Methamphetamine, 315, 327 Microsomes, platelet-activating factor (PAF), 1029 dopamine (DA) levels, 323 Microtubule-associated protein-2, effect ofcalpains, Methionine, 649 408 Methylaminoisobutyric acid, aminoacid transport, 619 Mild hypothermia, cerebral ischemia, 91 Methylamphetamine, 304 Milnacipran, 194 dopamine and serotonin, 327 Miniature endplate potentials (MEPP), 714 Subject Index 1211

Mitochondria, 376 Myelin basic protein (MBP), 137,239,970 malic enzyme, 765 autoantigen in MS, 114 Mitochondrial electron transport, beta-oxidation activ• endoproteinases, 1I11 ity, 752 in multiple sclerosis, 451 Mitochondrial NADH dehydrogenase, 312 Myelin oligodendrocyte glycoprotein (MOG), 137 Mitogen-activated protein (MAP) kinase, signal autoantigen in MS, 114 transduction cascade, 166 Myelin proteolipid, 234 MK-80 I, 55, 199,299,404, 833; see also Dizocilpine Myelin-associated glycoprotein (MAG), 137,239 MOLT-3,813 Myelin-associated proteins, 236 MOLT-3 human leukemic T-cell line, acetylcholine re• Myelogenesis, in pt rabbit brain, 233 ceptors, 813 Myo-inositol, 70 Monoamine hypothesis, of depression, 47 Monoamine oxidase (MAO), 79, 209, 287, 731, 773 Na,K-ATPase: see Sodium, potassium (Na+, K+) AT- delta-sleep inducing peptide, 757 Pase role in neuroprotection, 303 NADH: see Nicotinamide adenine dinucleotide Monoamine oxidase-B (MAO-B), 309, 315, 331 NADH ubiquinone reductase, 752 effect of L-deprenyl, 70 NADPH: see Nicotinamide adenine dinucleotide phos- Monoamine oxydase inhibitors, 189, 198 phate Monoamine oxidase-B inhibitor, (-)-deprenyl (Selegil• NADPH-diaphorase,832 ine),299 NADPH-oxidase complex, 17 Monoamine oxidase-B inhibitors, use in positron emis• NBAT/rBATID2 protein, aminoacid transport, 620 sion tomography, 1147 NCAM: see Neural cell adhesion molecule Monoaminergic systems, amphetamines, 323 Necrosis Monoamines amiridine, 346 cardiac arrest and resuscitation, 729 use of Bcl-2 expression, 323 diadenosine polyphosphates (ApnA), 695 Neocortex, 206 role in pain feeling, 472 cholinergic and serotonergic innervation, 149 Monoclonal antibody (192196),830 Neostriatum nerve growth factor (NGF) receptors, 830 dopamine release, 733 N-Monomethyl-L-arginine, 544, 626 inositol triphosphate and glutaminase, 389 Mononuclear leukocytes, acetylcholine receptors, 813 Neprilysin, nervous system, 684 Monophosphoinostide, 762 Nerve endings, 5'-nucleotidase, 702 Morphine, 198, 1019 Nerve growth factor (NGF) receptors, monoclonal anti• Morphochemical plasticity, dopamine system, 161 body (192196), 830 Mossy fiber terminals, 5'-nucleotidase, 702 Nerve growth factor (NGF), 260,501, 507, 703 Motor activity, n-3 fatly acids, 132 astrocytes, 50 I Motor behavior, during development, 475 effect on cholinergic function, 831 Motor neurons, 485 expression in astrocytes, 498 Motor unit number, 487 expression in non-neuronal cells, 513 Mouse L-cells, screening toxicity, 295 role of protein B-50/GAP-43, 1107 MPTP: see N-Methyl-4-phenyl-I,2,3,6-tetrahy• Nerve growth factor receptor (TrkA) dropyridine cholinergic neurons, 513 mRNA: see Messenger RNA expression in astrocytes, 498 Multi-infarct dementia, lipid spectrum and lysosomal Nerve injury, microglial cells, 550 enzymes 1025 Nerve terminals, gene expression, 637 Multiple sclerosis (MS), 105, 113, 137,268,433 Nervous tube defects, creatine kinase isoenzymes, 457 cytokines, 121 Neural cell adhesion molecule (NCAM), 857, 863 n-3 fatty acids, 131 ATPase activity, 710 NO synthase induction, 970 cell movement, 897 prostanoid levels, 542 immunoglobulin-like domains, 891 Muscarinic acetylcholine receptors, phosphorylation, 807 in multiple sclerosis, 451 spatial learning, 507 L2/HNK-1 carbohydrate, 929 Muscarinic MI receptors, 157 memory formation, 878 Muscimol, effect oftaurine to GABA-receptor bind• polysialic acid (PSA), 885, 929 ing, 962 Neural cell surface, binding ofNCAM, 893 Muscle action potential, gastrocnemius muscle, 486 Neural cells, arginine transport, 625 Myelin Neural crest, estrogen receptor, 524 autoreactive T cells, 114 Neural differentiation, 5'-nucleotidase, 705 endoproteinases, 1111 Neural tube defects, 295 1212 Subject Index

Neuralgia, 469 Neuroprotection Neurite differentiation, ecto-5'-nucleotidase, (-)-deprenyl, 299 705 amyloid precursor protein (sAPP), 165 Neurite extension, 5'-nucleotidase, 703 cerebral hypothermia treatment, 100 Neurite outgrowth, protein B50, 1107 melatonin, 601 Neuro-organic system, 221 role ofcyclooxygenase-2, 541 Neuroactive steroids, 275 taurine, 939 Neuroblastoma cell line, estrogen receptor, 524 tumor necrosis factor, 165 Neuroblastoma cells, overexpression of B-50/GAP-43, Neurorescue, (-)-deprenyl, 299 1107 Neurotensine, adrenal medulla, 595 Neuroblastoma N115 and OLN-93 cells, 240 Neurotoxicity, 312 Neuroblastoma NB-2a cells, effect ofcamitine on ace- protection by (-)-deprenyl, 300 tylchol, 1062 role ofcyclooxygenase-2, 541 Neuroblastoma SK-N-BE, retinoic acid, 1005 Neurotransmission, platelet-activating factor (PAF), Neuroblastoma SHSY-5Y, 685, 885 1029 Neurocan, proteoglycans, 901 Neurotransmitter receptors Neurodegeneration, during aging, 147 adenylate cyclase, 919 Neurodegenerative diseases, 538 in axonal segments, 649 dysfunction ofthe respiratory chain, 751 Neurotransmitter transporters, 773 neuroprotective agents, 40 I Neurotransmitter-based treatments, Alzheimer's dis- nimodipine and 8-0H-DPAT, 351 ease (AD), 153 Neurodegenerative disorders, 259, 315 Neurotransmitters, eicosanoids, 1019 Neurofibrillary tangles, 15 Neurotrauma, taurine ernux, 944 Neurofilament proteins Neurotrophins, 507 effect ofcalpains, 408 Neutral glycolipids, effect of temperature, 926 synthesis in axons, 673 Neutral proteinase, effect on myelin basic protein, Neurofilaments, cytoskeleton, 227 1115 Neurogranin, 43 Neutral proteinases, 343 Neurohypophysis, 291 Nicotinamide adenine dinucleotide, beta-oxidation ac• axonal ribosomes, 664 tivity,751 Neuroleptics, 198 Nicotinamide adenine dinucleotide phosphate, malic Neurological severity score (NSS), 23 enzyme isoforms, 765 Neuromodulin: see Protein B50 Nicotine receptors, 843 Neuron damage, dimethyl sulfoxide and 1,6-fructose ethanol, 748 diphospate, 173 Nicotine, dopamine release, 802 Neuron death, amiridine, 346 Nigral grafts, Parkinson's disease, 249 Neuron differentiation, retinoic acid, 1005 Nigrostriatal dopaminergic pathway, positron emis• Neuron survival, ecto-5'-nucleotidase, 705 sion tomography, 1145 Neuron-glia interactions, trimethyltin intoxication, Nimodipine, 148 497 calcium homeostasis, 402 Neuron-specific phosphoprotein B-50: see Protein NMDA-induced neurodegeneration, 352 B50 Nissl staining, 77 Neuronal damage, 73 Nitric oxide (NO), 17,625,967 Neuronal degeneration ACh release, 823 calpain activation, 407 activated microglia, 544 inositol-triphosphate and glutaminase, 390 calcium dependent proteolytic activity, 417 Neuronal energy metabolism, role ofglucose and lac- during epi lepsy, 977 tate, 561 effect on catecholamine release from adrenal c, 987 Neuronal interaction, 5'-nucleotidase, 703 hypothermia, 99 Neuronal plasticity, neuropeptides, 419 neurotoxicity, 541 Neuronal specific, 719 Nitric oxide pathway, oligodendrocytes, 626 Neurons Nitric oxide synthase (NOS), 967 diadenosine polyphosphates (ApnA), 695 melatonin, 602 inositol triphosphate and glutaminase, 389 Nitrite, n-3 fatty acids, 133 malic enzyme isoforms, 765 N-nitro-L-arginine, 626, 978, 990 Neuropeptide Y, adrenal medulla, 595 Nitrogen-I 3, 1140 Neuropeptides, neuronal plasticity, 419 use in positron emission tomography, 1140 Neurophysins, at oxygen epilepsy, 291 p-Nitrophenylethylamine, MAO-B substrate, 287 Neuropil threads, 15 p-Nitrophenylphosphate, 480 Subject Index 1213

3-Nitropropionic acid, 752 Nucleus ofthalamus, 1162 NMDA channel antagonists, neuroprotection, 402 NMDA glutamate receptor, tacrine, 345 Oedema, 480, 943 NMDA receptor-mediated transmission, ethanol, 748 histamine, 480 NMDA: see N-Methyl-D-aspartic acid regulation ofosmotic pressure, 943 NMDA-glutamate receptors, calpain 1,343 8-0H-DPAT: see 8-Hydroxydipropylaminotetralin NMR: see Nuclear magnetic resonance spectroscopy 6-0HDA: see 6-Hydroxdopamine NO synthase (NOS), neurotoxicity, 541 Oleic acid, 126 NO synthases (NOS), 625 Olfactory cortex tract, ofbrain polypeptides, 519 Nomifensine, use in positron emission tomography, Olfactory tract fibres, ofbrain polypeptides, 519 1146 Oligoclonal IgO bands, in cerebrospinal fluid, 436 Non-AD dementia, glutamine synthase, 444 Oligodendrocyte progenitors, 239 Non-steroidal anti-inflammatory drugs, 29 Oligodendrocytes, 227 Noradrenaline, 305, 469, 843 hypomyelination, 235 depression, 193 malic enzyme isoforms, 765 fos-expression after microdialysis injection, 1162 nitric oxide pathway, 626 glycogenolysis, 555 Oligodendrogl ial cells, ecto-5'-nucleotidase, 702 release of neurotransmitters from, 80I OLN-93 cell line, 239 role in pain feeling, 472 Oncogene transduction, 239 Noradrenaline receptor, hypertensive state, 853 Oncoproteins, trkS, 507 Noradrenaline release Opiate addiction, 268 effect of nitric oxid, 988 Opioid peptides, 529 factors M3l and M41, 597 adrenal medulla, 595 Noradrenaline reuptake inhibitors, 194 eicosanoids, 1019 Noradrenergic neurons, locus coeruleus, 243 Opioid receptors, 1019 Norepinephrine, 601 Optic nerve, axonal transport of proteins, 1101 antidepressant drugs, 197 Optic tectum, extracellular calcium, 395 cardiac arrest and resuscitation, 729 Oral tolerance, of EAE by spinal cord protein hydro• transporters, 774 lysate, 137 Normoxia, 566 Oreochromis mossambicus, 395 Northern blot analysis, 556 Organum vasculosum of lamina terminal is, effect of acetylcholine receptors, 813 xenobiotics, 529 de novo protein synthesis, axonal segments, 649 Ornithine, transport in neurons, 626 NSF: see N-Ethylmalcimide-sensitive fusion protein Ortho-phosphoric monoester hydrolase, 480 Nuclear DNA, axonal expression, 640 Osmosis, regulation ofosmotic pressure, 943 Nuclear glycoproteins, lectin-binding capacity, 910 Osmotic stress, 571 Nuclear magnetic resonance spectroscopy, 183,631 Ouabain, 557 compartmentation of glucose metabolism, 1065 Oxidation, carnitine translocase, 1040 glial lipid metabolism, 571 Oxidative phosphorylation ofcarnosine, 178 amiridine, 348 Nuclear membrane lectin, nucleo-cytoplasmic relation• role of phosphate activated glutaminase, 1077 ship,911 Oxidative stress, 17 Nuclear transcription factor NFKB, 168 Oxoglutarate, 740, 1079 Nucleo-cytoplasmic relationship, nuclear membrane release from astrocytes, 1066 lectin, 91 I Oxoglutarate dehydrogenase, 737, 824 Nucleosides, as neurotransmitters, 357 Oxygen based radicals, effect of L-deprenyl, 79 Nucleotidase, neuritic differentiation and neuron sur• Oxygen consumption, uncoupling from blood flow vival,701 and glucose utilization, 559 Nucleotides Oxygen radicals, 300 adrenal medulla, 595 Oxygen-IS, use in positron emission tomography. 1140 as neurotransmitters, 357 Oxytocin mRNA, in axons, 664 Nucleus accumbens, 209 dopamine release, 1157 PI Purinoceptor, adenosine, 357 Nucleus basalis, calcium homeostasis, 401 P2 purinoceptor, glutamate release, 358 Nucleus basalis magnocellularis, NOF and TrkA ex• P2-purinoceptor subtypes, 698 pression, 513 PAF: see Platelet-activating factor Nucleus basalis of Meynert, cortical cholinergic dys• Pain threshold, n-3 fatty acids, 132 function, 829 Pallidonigral neurons, taurine and OABA release. 957 Nucleus caudatus, synaptic structures, 492 Palmitic acid, beta-oxidation, 752 1214 Subject Index

Palmitoylcamitine transferase, transport in neuronal Phosphatidic acid, effect ofreoxygenation, 465 membranes, 1059 Phosphatidylcholine, 1026 Pancreastatin, action in liver membranes, 589 multiple infarct dementia, 1026 Pancreastatin receptors, liver membranes, 590 Phosphatidylethanolamine, 762 Pancreatic islets, chromogranin A, 584 Phosphatidylethanol, phospholipase D, 744 Pancreatic secretion, effect on pancreastatin, 589 Phosphatidylethanolamine, multiple infarct dementia, Panic attacks, cholestokinin type B receptor, 1089 1026 Paralytic tremor, PLP gene mutant rabbit, 233 Phosphatidylinositol, 507 Parathormone release, effect on pancreastatin, 589 effect of reoxygenation, 465 Parathyroid gland, chromogranin A, 583 Phosphatidylinositol transfer protein, location and Parathyroid hormone, chromogranin A, 583 characterization, 999 Parkinson's disease (PD), 259, 309, 315, 324, 328 Phosphatidylinositol-4,5-bisphosphate, plasma mem• cells for transplantation, 249 brane,999 H-deprenyl, 308 Phosphatidylserine, 762 free radicals, 611 effect ofreoxygenation, 465 glutamine synthase, 444 Phosphatidylserine synthesis, role ofcalcium and pro• glutathione (GSH), 243 tein kinase C, 1011 nitric oxide (NO), 823, 977 Phosphocholinetransferase, platelet-activating factor PET study ofdopamine receptors, 1146 (PAF), 1029 positron emission tomography (PET), 1149 Phosphodiesterase, 596 selegiline,331 Phosphoinositide, 1019 Parkinsonism, 268 Phospholipase, pancreastatin, 591 PariodeI, 102 Phospholipase A2, tricyclic antidepressants, 1035 Paroxetine, 194, 774 Phospholipase C, 1019 Paroxysmal activity, autoantibodies, 265 Phospholipase D, phosphatidylethanol, 744 Parvalbumin, 830 Phospholipid antibodies, 281 Patch-clamp detection, capillary electrophoresis, 1133 Phospholipid glycerides, delta-sleep inducing peptide, PC 12 cells, 722 761 apoptosis, 260 Phospholipid turnover, carnitine palmitoyltransferase, ecto-5'-nucleotidase, 702 1053 exocytosis, 725 Phospholipids, 129 overexpression of B-50/GAP-43, 1107 delta-sleep inducing peptide, 761 PC 12 phaeochromocytoma, secretion, 252 effect of temperature, 926 PCR: see Polymerase chain reaction in Alzheimer's disease, 33 Penicillin-induced epilepsy, 287 transfer between membranes, 999 Penthylenetetrazol, 978 tricyclic antidepressants, 1035 Pentoxifylline, 123 under acute osmotic stress, 573 Periaxoplasmic plaques, 667 Phosphoprotein phosphatase, 479 Peroxidation of lipids, delta-sleep inducing peptide, Phosphoramidon, 684 761 Phosphorylation Peroxisome proliferator-activating receptors, retinoic effect of protein kinase C, 1071 acid, 1005 ofacetylcholine receptors, 807 Peroxyl radical, effect on melatonin, 599 Pichia pas/oris Pertussis toxin-sensitive G protein, pancreastatin, 591 neural cell adhesion molecule (NCAM), 891 Pethidine, interaction with selegiline, 336 serotonin transporter expression, 778 Phenobarbital, 304 Picrotoxin, 276 Phenyalanine, aminoacid transport, 622 Pineal organ, 611 Phenylethylamine, 304 Piperidine-3-sulphonic acid, taurine uptake, 961 Phenytoin, n-3 fatty acids, 133 Piracetam, hypokinesia, 1085 Pheochromocytoma cell line (PCI2), 526 Pirenzepine, 148 Pheochromocytoma, overexpression of B-50/GAP-43, Pirrolidine-2-4-dicarboxylate, 567 1107 Pisum Sa/ivum agglutinin, 910 Phorbol-12-myristate-13-acetate, phosphorylation of Pituitary, effect ofxenobiotics, 529 brain proteins, 1071 Pituitary hormones, hypothermia treatment, 102 Phosphate activated glutaminase Pituitary tissue, hyperalbuminization, 292 isoforms, 1077 Plasma membrane 2 neurons, 390 Ca +-transport ATPase, 376 Phosphate, glutamine hydrolyse, 1079 phosphatidylinositol,999 Phosphathidylcholine, 762 Plasma, acetylcholine (ACh), 813 Subject Index 121S

Platelet-activating factor (PAF), cytidine 5'-monophos• Promedol,1019 phate, 1029 Propranolol, 565 PLP: see Proteolipid protein N-n-Propylnorapomorphine, 215 Polyacrylamide gel electrophoresis (PAGE) N-Propylpentanoic acid, neural tube defects, 295 brain polypeptides, 519 Prostacyclin I), vasodilator, 130 CAM kinase II, 370 Prostaglandins, 127,469,535 glutamine synthase, 444 piracetam, 1087

MYPIOO, 676 Prostaglandin °2, 470 Polymerase chain reaction (PCR), axonal mRNA, 639 interferon-y, 544

Polymyxin B, 975 Prostaglandin E2, 470 Poly(0-phenylenediamine),577 cAMP levels, 545 Polypeptides inflammatory responses, 129 brain slices, 521 interferon-y, 544 synthesis in axons, 673 neuroprotective action, 541

Polyphosphoinositides, calcium dependent proteolytic Prostaglandin F2a, 470 activity, 417 Prostanoids, neuroprotection, 541 Polysialic acid (PSA), differentiation and neuritic out• Proto-oncogene, estrogens, 524 growth,885 Protein B50, neurite outgrowth and regeneration, Polysialic acid, 863 1107 binding to NCAM, 879 Protein 14-3--3, exocytosis, 722 Polysialyltransferase, 886 Protein acylation, carnitine, 1056 Polysomes Protein Exo I, el(ocytosis, 722 axonal protein synthesis, 644 Protein Ex02, el(ocytosis, 722 squid giant axon, 663 Protein fraction PF-2, nucleo-cytoplasmic relation• Polyunsaturated fatty acids, 37 ship, 91 I leech gangl ia, 983 Protein kinase A, 556 melatonin, 600 phosphorylation of ACh receptors, 807 multiple sclerosis, 125 protein el(02, 722 neuron differentiation, 1005 serotonine transporters, 774 n-3 Polyunsaturated fatty acids, multiple sclerosis, 125 Protein kinase C, 169, 556, 692. 715, 798, 830. 973. n-6 Polyunsaturated fatty acids, multiple sclerosis, 1033, 1107 125 effect ofcalpains. 408, 410 Porcine pancreas, pancreastatin, 589 palmitoylcarnitine, 1062 Portacaval shunt, 201 phosphat idyl serine synthesis, 1012 Positron emission tomography (PET) phosphorylation of ACh receptors, 807 activation-induced glycolysis, 558 phosphorylation of brain proteins, 1071 dopamine receptor mapping, 1139, 1145 phosphorylation of MYP 100, 679 fluoro-3,4-dihydrol(yphenylalanine. 1149 phosphorylation of synaptic proteins. 1095 Potassium channels serotonine transporters, 774 in microglia, 536 spatial learning paradigm, 507 scorpion tOl(ins, 784 Protein kinase M, formation by calpains. 411 tacrine, 345 Protein of the synaptic vesicle membrane, 714 Potassium cyanide, melatonin, 60 I Protein 5-100, in multiple sclerosis (MSl. 451 Potassium transport, tetra-butylhydrol(ide, 983 Protein synthesis Potassium axonal segments, 647 AChR-mediated dopamine release, 802 effect of reoxygenation, 465 microglial activation, 535 in al(ons, 667 uptake ofarginine, 626 synaptosomal fractions, 643 Prealbumin, 425 de novo Protein synthesis, axonal segments, 649 Preoptic area of hypothalamus, effect of xenobiotics, Protein turnover. 667 529 Proteins, al(onal segments, 647 Presenilin genes, 21 Proteoglycans, 858, 90 I Probenecid, effect on lactate transport, 565 Proteolipid mRNA, 236 Prolactin, 188 Proteolipid protein (PLP), 234, 239 gonadoliberin, 530 autoantigen in MS, 114 Proline, 774 Proteolysis, myelin basic protein, II11 transporters, 774 Proteolytic activity Proline directed kinase, phosphoylation ofsynaptic calcium dependent proteolytic activity, 417 protei ns, 1095 lymphocytes, 417 1216 Subject Index

Proton magnetic resonance spectroscopy (I H-MRS) Retina, melatonin, 605, 613 activation-induced glycolysis, 558 Retinoic acid, role in neuron differentiation, 1005 ofcarnosine, 177 Retzius nerve cell, reactive oxygen species, 983 Prozac,774 Reverse transcription-polymerase chain reaction, ace- Purines, 357 tylcholine receptors, 813 Purinoreceptors, 707 Rewarding stimuli, effect on dopamine release, 1157 Purkinje cells, brevican immunostaining, 903 Rheobase voltage, dystrophic mdx mice, 462 Pyramidal cells, 497 Ribonuclease (RNase), 644 Pyridine-3-sulphonic acid, taurine uptake, 961 Ribonucleoprotein particles Pyrithiamine, 737 in axons, 664 Pyruvate, 739, 821 in nerve- terminals, 675 acetylcarnitine, 1048 Ribosomal RNA (rRNA), 667 metabolic trafficking, 1070 in axons, 638, 667 Pyruvate carboxylase, 631 Ribosomes, in axonal segments, 659 metabolic trafficking, 1067 Ricinus communi agglutinin, 910 Pyruvate dehydrogenase, 631, 1044 Rotenone, beta-oxidation activity, 752 acetylcholine release, 737 RTI-12I, use in positron emission tomography, 1142 inherited deficiencies, 821, 825 RutiJus rutiJus. 396 metabolic trafficking, 1067 Ryanodine, 363 Pyruvate utilization, 993 Ryanodine receptors [RyR), 361 effect ofethanol, 847 calcium homeostasis, 402

Quaking mouse, 211 S-Ioo: see Protein S-I 00 Quality assurance, 433 Sambucus nigra agglutinin, 910 2 Quinolinic acid, inositol-triphosphate and glutami- Sarco-endoplasmic reticulum Ca + transport ATPase, nase, 390 376,383 Quinpirole, 606 Sarcolemma, role ofcalcium, 461 Quinuclidinyl benzilate (QNB), 148,825,855 Sarcoplasmic reticulum, calcium ion release, 461 Quisqualate, 266 SB 206553, 70 phosphorylation of brain proteins, 1071 SCH 23390, 211 use in positron emission tomography, 1142 Rab3a, anterograde transport in optic nerve, 1104 Schizophrenia, 268 Rabies, induction of NO-synthase, 968 glutamine synthase, 444 Rabphilin, phosphorylation of proteins and dynamin, Schwann cell, 228 1095 Sciatic nerve Rabphilin-3A,1104 distal motor latency, 487 anterograde transport in optic nerve, 1104 microglial reaction, 549 Raclopride Scorpion toxins, potassium channels, 784 N-acetyltransferase, 607 Selectin family use in positron emission tomography, 1142 cell-cell adhesion molecules, 857 Raphe nucleus, 5-hydroxytryptamine, 189 leukocytes, 929 Rasmussen-encephalitis, 281 Selegiline, 315 Rassmussen disease, 272 dopamine, 327 Rat glioma BT4Cn, neural cell adhesion molecule monoamine oxidase-B inhibitor, 299 (NCAM),897 neuroprotective effect, 79 Ray electric organ. major vault protein, 679 Parkinson's disease, 331 Reactive blue 2, 358 Senile dementia of Alzheimer's type (SOAT). tacrine Reactive oxygen species (ROS), 33, 244 and amiridin. 345 leech ganglia, 983 Sensomotor cortex, 162, 288 melatonin, 614 Sensorimotor structures, adenylate cyclase, 919 sodium, potassium-ATPase activity. 973 Sensory-motor deficits. dimethyl sulfoxide (OM SO) Receptor binding kinetics, interleukin-I, 502 and 1,6-fructose, 173 Regeneration Serine, carnitine transport, 1060 regulation of neuronal function by astrocytes. 501 Serine/threonine kinases, 369 role of ependymin, 872 Serotonin (5-HT), 148, 187, 20 1,469, 773; see a/so 5- Reoxygenation, effect on phospholipids, 465 Hydroxytryptamine Reperfusion, effect on phospholipids, 465 amacrine cells, 612 Reproductive system, effect of xenobiotics, 529 antidepressant drugs, 197 Resuscitation, norepinephrine and epinephrine, 729 depression, 193 Subject Index Il17

Serotonin (5·HT) (cant.) Sodium, potassium-ATPase, 557. 797 effect ofxenobiotics, 259 effect ofglutamate, 973 estrogen-induced differentation, 525 Sodium, potassium pump, 222 MAO-A substrate, 287 Solanum tuberosum agglutinin. 910 methamphetamine, 327 Soluble NSF attachment protein receptors, exocytosis, rabies virus, 968 723 role in pain feeling, 472 Soluble NSF attachment proteins, exocytosis, ) Serotonin (5-HT 1A agonist, neuroprotection, 402 723 Serotonin N-acetyltransferase, dopamine receptor Somatostatin, adrenal medulla, 595 blockers, 605 Soybean agglutinin, 910 Serotonin receptor, 157 Spatial learning, polysialic acid associated with

5-HT JA subtype, 47,55,351 NCAM,864 5-HT2C subtype, 69 Spatial learning paradigm, changes in protein kinase

5-HT ID subtype, 59 C, acetylcholine receptors and trkB, 508 relation with ACh-receptor, 801 Spatial orientation task, changes in protein kinase C, Serotonin reuptake inhibitors (SSRls), 189, 193, 198 acetylcholine receptors and trkB, 508 Serotonin transporter, 773 Spectrin, 408, 417 Serum amyloid P, 16 Sphingolipids Sexual differentiation, brain, 523 as second messenger, 260 SH-SY5Y cells, 793 multiple infarct dementia, 1027 SH-SY5Y, retinoic acid induced differentiation, 886 Sphingomyelin, 762 Shaping process, 222 Sphingomyelin-dependant transduction system, Sialic acid transferases, meningiomas, 917 259 Sialo-glycosphingolipids, effect of temperature, 926 Sphingomyelinase, 168 Sialyltransferases, 886 Sphingosine, 169 Signal transduction processes, carnitine, 1056 Spina bifida aperta, motor behavior, 475 Signal transduction, calcium, 369 Spinal cord ischemia, MRI study, 184 Single photon emission computed tomography Spinal cord trauma, neuroprotective agents, 401 (SPECT), dopamine receptors, 1146 Spinal cord, superoxide dismutase, 489 Singlet oxygen, effect on melatonin, 599 Spinocerebellar atrophy, glutamine synthetase, 443 SK-ER3 cells. 17-beta-oestradiol, 524 Spiperone, 211 SKF-525A, 304 Spiroperidol. 606 Small proteins, calcium dependent proteolytic activity, N-acetyltransferase, 607 417 Spodopterafrugiperda.693 SNAP-25: see Synaptosomal-associated protein, 25KDa SQ22, 536, 545 SNAPs: see Soluble NSF attachment proteins Squid giant axon SNAREs: see Soluble NSF attachment protein recep- polysomes, 663 tors protein synthesis, 644 SOD: see Superoxide dismutase Squid photoreceptor neurons, 663 Sodium, 376, 973, 1060 Staurosporine, 1072 AChR-mediated dopamine release, 802 Stem cells, Parkinson's disease, 254 choline transport, 837 Steroid treatment. in multiple sclerosis (MS), 454 effect on taurine levels, 945 Stratum fibrosum et griseum superficiale, y-ami- Sodium azide, 709 nobutyric acid, 397 amiridine, 348 Stratum marginale, y-aminobutyric acid, 397 beta-oxidation activity, 752 Stress factor, aminobutyric acid, 1083 Sodium, calcium antiporter, role in homeostasis, 402 Stretch receptor neurons, amiridine and tacrine, Sodium channel, polysialic acid (PSA), 885 345 Sodium channels Striatonigral neurons, taurine and GABA release, 949, AChR-mediated neurotransmitter release, 803 955 polysialic acid, 867 Striatum, dopamine release, 80 I a-toxins, 783 Stroke, 83 Sodium cyanide, beta-oxidation activity, 752 mild hypothermia therapy, 92 Sodium-dependent active transport, 316 nitric oxide (NO), 977 Sodium fluorescein. 480 Strychnine, alanine responses, 1123 Sodium fluoride, adenyl ate cyclase, 921 Subarachnoid space, 423 Sodium nitroprusside, 824 Substance P, 469 catecholamine release, 988 adrenal medulla, 595 generation of nitric oxide, 994 idiopathic neuralgia, 472 1218 Subject Index

Substantia nigra, 76, 259, 309 Teleosts, retinotectal projection, 870 glutathione (GSH), 243 Temperature ofthe brain, regulation mechanisms, 97 Parkinson's disease, 249 Temperature, effect on gangliosides, 925 taurine and GABA release, 949 Tenascin-R, N-glycosylation sites, 929 Succinate ubiquinone reductase, 752 Tenebrio molitor, camitine, 1039 Succinate, 1079 Tenidap,30 Sulfamoylbenzo(f)quinoxaline, 734 Tetra-butylhydroxide, potassium transport, 983 Sulpiride, N-acetyltransferase, 607 Tetrapeptide tuftsin (Thr-Lys-Pro-Arg), 287 Superoxide anions, n-3 fany acids, 133 Tetrodoxin, 803, 844 Superoxide dismutase, 169,304,323,983 taurine release, 950 amyotrophic lateral sclerosis (ALS), 485 Thalamic nuclei, NGF and trkA expression, 513 lipid peroxidation, 489 Thapsigargin, 384,1012 sodium, potassium-ATPase activity, 973 Thermoregulation, n-3 fatty acids, 132 Superoxide radicals, methamphetamine, 323 Thiamine deficiency Suppressor T cells, n-3 fatty acids, 131 acetylcholine release, 737 Suramin, 709 acetylcholine synthesis, 821 ecto-ApnA hydrolase, 698 effects on ACh-synthesis, 824 ecto-nucleotidases, 700 Thiamine pyrophosphate, 738 Sympathetic ganglion neurons, acetylcholine, 843 Thiamine pyrophosphate-dependent enzymes, acetyl• Synapsin, axonal transport and Rab3a, 1102 choline release, 737 Synapsins, phosphorylation ofsynaptic proteins, 1095 Thiamine triphosphates, 741 Synaptic membrane, 857 Thiobarbituric acid-reactive substances (TBARS), 33, Synaptic proteins 614,979 GAP-43,43 Thiopental, 278 rab-3a,43 Thiosemicarbazide, 978 Synaptic structures, 223 5'-0-3-Thiotriphosphate, ecto-nucleotidases, 700 amygdala, 492 Threohydroxyaspartate, 556, 566 , nucleus caudatus, 492 Thromboxane A2 vasoconstrictor and thrombosis, 129 Synaptic terminals, diadenosine polyphosphates Thromboxane A3, 130 (ApnA),695 Thromboxane B2, interferon-y, 544 Synaptic vesicle cycling, 1095 Thyroid hormones, TRH-degrading ectoenzyme, 692 Synaptobrevin, exocytosis, 723 Thyrotropin-releasing hormone (TRH), degrading ecto- Synaptophysin,43 enzyme, 691 anterograde transport in optic nerve, 1104 TNF: see Tumor necrosis factor Synaptosomal fractions, protein synthesis, 643 Tocopherol, 599, 761 Synaptosomal membranes, neutral proteinases, 343 liver enzymes, 333 Synaptosomal-associated protein, 25 kDa Torpedo electric organ, ecto-nucleotidases, 696 acetylcholine release, 714 Torpedo marmorata, vault proteins, 675 exocytosis, 723 a Toxins, sodium channels, 783 Synaptosomes ~ Toxins, activation of sodium channels, 784 choline transport, 838 Trace protein assay, 424 torpedo electric organ, 676 Trafficking in fetal brain, cerebral glucose, glutamate Synaptotagmin,43 and glutamine, 631 Synaptotagmin I, anterograde transport in optic nerve, Transcription factor NFKB, 260 1104 Transforming growth factor beta (TGF-beta), 116, Syntaxin, 714 121,970 exocytosis, 723 effect on NO production in, 970 Transgenic mice, mature NFH-IacZ, 229 TBARS: see Thiobarbituric acid-reactive substances Transgenic G93A mice, muscle action potential, 486 T cell-induced EAE, macrophage depletion, 106 Transplantation, dopamine cells, 249 Tacrine, senile dementia ofAlzheimer's type (SDAT), 345 Transport ofacyl moieties, camitine, 1047 Tacrine-like compounds, endplate potentials, 715 Transport system y+, amino acids, 626 Taltrimide, taurine agonist, 942 Transthyretin, 425 Tartrate, effect on acid phosphatase, 481 Transverse rubules, calcium ion release, 461 Taurine, 299, 529, 959 Trauma, nitric oxide (NO), 977 effect glutamate and GABA, 963 TRH: see Thyrotropin-releasing hormone neuroprotection, 939 Tricarboxylic acid (TCA) cycle regulation ofosmotic pressure, 943 glucose, glutamate, and glutamine trafficking, 631 taurine and GABA release, 949, 955 metabolic trafficking, 1065 Subject Index 1219

Tricyclic antidepressants, 193,774 Vasogenic brain oedema, histamine, 480 phospholipase A2, 1037 VCisopressin mRNA, in axons, 664 Triethyltin, n-3 fatty acids, 133 Vault protein, homolog of lung resistance-related pro- Trigeminal nerve, 469 tein, 675 Triglyceride fatty acid turnover, carnitine palmitoyl- Vault, ribonucleoprotein panicle, 675 transfe 1053 Venlafaxine, 194 Triglycerides, multiple infarct dementia, 1027 Ventral tegmental area, injection ofdrug by microdia- Trimetaphan, dopamine release, 802 lysis, 1163 Trimethaphosphatase, 479 Veratridine, 803 4-N-Trimethylammonium-3-hydroxybutyric acid: see Versican, proteoglycans, 901 Carnitine Vigabatrine, 278 N,N,N-Trimethyltaurine, taurine uptake, 961 Vimentin, 239 Trimethyltin, NGF-expression in astrocytes, 497 Vinculin, NCAM, 899 Triphosphate, pancreastatin, 591 VIP: see Vasoactive intestinal polypeptide Transfer RNA, in axons, 638 Viral infections, induction of NO-synthase, 968 Tryptophan hydroxylase, 605 Vitamin A metabolite, retinoic acid, 1005 Tryptophan, 201, 605 Vitamin E, 489 2 in depression, 187 Voltage-dependant Ca + channels, effect of nimodip• Tubulin, 673 ine, 351 acetylation, 1056 synthesis in axons, 673 Wallerian degeneration, microglial reaction, Tuftsin, 288 549 Tumor necrosis factor (TN F), 27, 130, 165 WAY I00635, use in positron emission tomography, Tumor necrosis factor u (TNF-u), 121, 259 1143 selective BBB-damage, 142 Western blot Tumor necrosis factor ~ (TNF-~), 121 calcium-binding proteins, 384 Tumor necrosis factors, 536 InsP3 receptor, 376 Tumor-promoting phorbol ester, phosphorylation of glutamine synthase, 444 brain proteins, 1071 MVPIOO, 676 Tyrosine hydroxylase, estrogen-induced differentia• proteins ofneostriatum, 390 tion, 525 Wheat germ agglutinin, 910 Tyrosine protein kinase, phosphorylation of MVPIOO, Wistar rats, 738 680 Wolfgram protein (CNP), 239

Ubiquinol cytochrome c reductase, 752 Xenobiotics Unitas multiplex, 221 hypothalamic circadian rythm, 529 Uridine monophosphate (UMP), effect on platelet-acti- Parkinson's disease, 246 vating factor, 1032 Xenografts, Parkinson's disease, 254 Uridine triphosphate, 70 I Xenopus laevis oocytes, neutral amino acid transport, UTP: see Uridine triphosphate 620 UV-A light, effect on N-acetyltransferase, 606 Xenopus oocytes, alanine expression, 1129

Valproic acid, neural tube defects, 295 Yeast, 778 VAM P/synaptobrevin, acetylcholine release, 714 neural cell adhesion molecule (NCAMl, 891 Vanadate, 387 YM022, cholestokinin type B receptor, 1089 Vascular cell adhesion molecule-I (VCAM-I l, 122, 858 YOYO-I, nucleic acid binding, 668 Vascular dementia, lipid spectrum and lysosomal en- zymes, 1025 Zinc metalloenzymes, 683 Vasoactive intestinal polypeptide Zinc metallopeptidase, 692 adrenal medulla, 595 Zinc, binding to ependymin, 871 glycogenolysis, 555 Zinc-proteases, 714