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Edinburgh Research Explorer Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Citation for published version: Van Erp, TGM, Walton, E, Hibar, DP, Schmaal, L, Jiang, W, Glahn, DC, Pearlson, GD, Yao, N, Fukunaga, M, Hashimoto, R, Okada, N, Yamamori, H, Clark, VP, Mueller, BA, De Zwarte, SMC, Ophoff, RA, Van Haren, NEM, Andreassen, OA, Gurholt, TP, Gruber, O, Kraemer, B, Richter, A, Calhoun, VD, Crespo- facorro, B, Roiz-santiañez, R, Tordesillas-gutiérrez, D, Loughland, C, Catts, S, Fullerton, JM, Green, MJ, Henskens, F, Jablensky, A, Mowry, BJ, Pantelis, C, Quidé, Y, Schall, U, Scott, RJ, Cairns, MJ, Seal, M, Tooney, PA, Rasser, PE, Cooper, G, Shannon Weickert, C, Weickert, TW, Hong, E, Kochunov, P, Gur, RE, Gur, RC, Ford, JM, Macciardi, F, Mathalon, DH, Potkin, SG, Preda, A, Fan, F, Ehrlich, S, King, MD, De Haan, L, Veltman, DJ, Assogna, F, Banaj, N, De Rossi, P, Iorio, M, Piras, F, Spalletta, G, Pomarol-clotet, E, Kelly, S, Ciufolini, S, Radua, J, Murray, R, Marques, TR, Simmons, A, Borgwardt, S, Schönborn- harrisberger, F, Riecher-rössler, A, Smieskova, R, Alpert, KI, Bertolino, A, Bonvino, A, Di Giorgio, A, Neilson, E, Mayer, AR, Yun, J, Cannon, DM, Lebedeva, I, Tomyshev, AS, Akhadov, T, Kaleda, V, Fatouros- bergman, H, Flyckt, L, Rosa, PGP, Serpa, MH, Zanetti, MV, Hoschl, C, Skoch, A, Spaniel, F, Tomecek, D, Mcintosh, AM, Whalley, HC, Knöchel, C, Oertel-knöchel, V, Howells, FM, Stein, DJ, Temmingh, HS, Uhlmann, A, Lopez-jaramillo, C, Dima, D, Faskowitz, JI, Gutman, BA, Jahanshad, N, Thompson, PM, Turner, JA, Farde, L, Flyckt, L, Fatouros-bergman, H, Cervenka, S, Agartz, I, Collste, K, Victorsson, P, Engberg, G, Erhardt, S, Schwieler, L, Malmqvist, A, Hedberg, M, Orhan, F, Piehl, F & Agartz, I 2019, 'Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?', Biological Psychiatry, vol. 85, no. 7. https://doi.org/10.1016/j.biopsych.2018.10.003 Digital Object Identifier (DOI): 10.1016/j.biopsych.2018.10.003 Link: Link to publication record in Edinburgh Research Explorer Document Version: Peer reviewed version Published In: Biological Psychiatry Publisher Rights Statement: This is the author's peer-reviewed manuscript as accepted for publication. 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Biological Psychiatry Collaborative meta-analyses and mega-analyses of magnetic resonance imaging data increase our knowledge about brain disorders --Manuscript Draft-- Manuscript Number: BPS-D-18-01390 Full Title: Collaborative meta-analyses and mega-analyses of magnetic resonance imaging data increase our knowledge about brain disorders Article Type: Correspondence Corresponding Author: Theo G.M. van Erp, Ph.D. University of California, Irvine Irvine, CA UNITED STATES Order of Authors: Theo G.M. van Erp, Ph.D. Esther Walton Derrek P Hibar Lianne Schmaal Wenhao Jiang David Glahn Godfrey D Pearlson Nailin Yao Masaki Fukunaga Ryota Hashimoto Naohiro Okada Hidenaga Yamamori Vincent Clark Bryon Mueller Sonja MC de Zwarte Roel A Ophoff Neeltje van Haren Ole A Andreassen Tiril P Gurholt Oliver Gruber Bernd Kraemer Anja Richter Vince D Calhoun Benedicto Crespo-Facorro Roberto Roiz-Santiañez Diana Tordesillas-Gutiérrez Carmel Loughland Stanley Catts Janice M Fullerton Melissa J Green Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Frans Henskens Assen Jablensky Bryan J Mowry Christos Pantelis Yann Quidé Ulrich Schall Rodney J Scott Murray J Cairns Marc Seal Paul A Tooney Paul E Rasser Gavin Cooper Cynthia Shannon Weickert Thomas W Weickert Elliot Hong Peter Kochunov Raquel E Gur Ruben C Gur Judith M Ford Fabio Macciardi Daniel H Mathalon Steven G Potkin Adrian Preda Fengmei Fan Stefan Ehrlich Margaret D King Lieuwe De Haan Dick J Veltman Francesca Assogna Nerisa Banaj Pietro de Rossi Mariangela Iorio Fabrizio Piras Gianfranco Spalletta Edith Pomarol-Clotet Sinead Kelly Simone Ciufolini Joaquim Radua Robin Murray Tiago Reis Marques Powered by Editorial Manager®Andrew Simmonsand ProduXion Manager® from Aries Systems Corporation Stefan Borgwardt Fabienne Harrisberger Anita Riecher-Rössler Renata Smieskova Kathryn I Alpert Alessandro Bertolino Aurora Bonvino Annabella Di Giorgio Emma Neilson Andrew R Mayer Je-Yeon Yun Dara M Cannon Irina Lebedeva Alexander S Tomyshev Tolibjohn Akhadov Vasily Kaleda Helena Fatouros-Bergman Lena Flyckt Karolinska Schizophrenia Project (KaSP) Pedro GP Rosa Mauricio H Serpa Marcus V Zanetti Cyril Hoschl Antonin Skoch Filip Spaniel David Tomecek Andrew M McIntosh Heather C Whalley Christian Knöchel Viola Oertel-Knöchel Fleur M Howells Dan J Stein Henk Temmingh Anne Uhlmann Carlos Lopez-Jaramillo Danai Dima Joshua I Faskowitz Boris A Gutman Neda Jahanshad Paul M Thompson Powered by Editorial Manager®Jessica Aand Turner ProduXion Manager® from Aries Systems Corporation Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Manuscript Click here to view linked References Collaborative meta-analyses and mega-analyses of magnetic resonance imaging data increase our knowledge about brain disorders Reply to: New meta-analyses and mega-analyses of MRI findings in schizophrenia: do they really increase our knowledge about the nature of the disease process? Theo GM van Erp1*, Esther Walton2, Derrek P Hibar3,4, Lianne Schmaal5,6,7, Wenhao Jiang8, David C Glahn9,10, Godfrey D Pearlson9,10, Nailin Yao9,10, Masaki Fukunaga11, Ryota Hashimoto12,13, Naohiro Okada14, Hidenaga Yamamori13, Vincent P Clark15,16, Bryon A Mueller20, Sonja MC de Zwarte21, Roel A Ophoff21,22, Neeltje EM van Haren21,116, Ole A Andreassen17,23, Tiril P Gurholt17,18, Oliver Gruber28,29, Bernd Kraemer28,29, Anja Richter28,29, Vince D Calhoun15,16, Benedicto Crespo-Facorro31,32, Roberto Roiz-Santiañez31,32, Diana Tordesillas-Gutiérrez31,32,68, Carmel Loughland47,49,115, Stanley Catts36, Janice M Fullerton38,39, Melissa J Green34,38, Frans Henskens40,123,47, Assen Jablensky41, Bryan J Mowry42,43, Christos Pantelis37,45, Yann Quidé34,38, Ulrich Schall46,47, Rodney J Scott33,47, Murray J Cairns33,47, Marc Seal48, Paul A Tooney33,47,49, Paul E Rasser49, Gavin Cooper49, Cynthia Shannon Weickert34,38, Thomas W Weickert34,38, Elliot Hong52, Peter Kochunov52, Raquel E Gur53, Ruben C Gur53, Judith M Ford57,58, Fabio Macciardi1, Daniel H Mathalon57,58, Steven G Potkin1, Adrian Preda1, Fengmei Fan61, Stefan Ehrlich66,67, Margaret D King16, Lieuwe De Haan70, Dick J Veltman72, Francesca Assogna73,74, Nerisa Banaj73, Pietro de Rossi73,75,76, Mariangela Iorio73, Fabrizio Piras73,74, Gianfranco Spalletta73,77, Edith Pomarol-Clotet78,79, Sinead Kelly80,81, Simone Ciufolini83, Joaquim Radua19,78,79,83,119, Robin Murray83, Tiago Reis Marques83, Andrew Simmons83, Stefan Borgwardt85, Fabienne Schönborn-Harrisberger85, Anita Riecher-Rössler85, Renata Smieskova85, Kathryn I Alpert86, Alessandro Bertolino88, Aurora Bonvino89, Annabella Di Giorgio89, Emma Neilson90, Andrew R Mayer16, Je-Yeon Yun93,94, Dara M Cannon95, Irina Lebedeva96, Alexander S Tomyshev96, Tolibjohn Akhadov97, Vasily Kaleda96, Helena Fatouros- Bergman98, Lena Flyckt98, Karolinska Schizophrenia Project (KaSP)99, Pedro GP Rosa100,101, Mauricio H Serpa100,101, Marcus V Zanetti100,101, Cyril Hoschl102, Antonin Skoch102,103, Filip Spaniel102, David Tomecek102,120,121, Andrew M McIntosh90,104, Heather C Whalley90, Christian Knöchel106, Viola Oertel-Knöchel106, Fleur M Howells107, Dan J Stein107,108, Henk S Temmingh107, Anne Uhlmann107,109, Carlos Lopez-Jaramillo110, Danai Dima111,112, Joshua I Faskowitz3, Boris A Gutman122, Neda Jahanshad3, Paul M Thompson3, Jessica A Turner16,118 1Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA 2Medical Research Council Integrative Epidemiology Unit and Bristol Medical School, Population Health Sciences, University of Bristol, United Kingdom 3Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA 4Janssen Research & Development, San Diego, CA, USA 5Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia 6Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia 7Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands 8Department of Psychology, Georgia State University, Atlanta, GA, USA 2 9Department of Psychiatry, Yale University, New Haven, CT, USA 10Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA 11Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan 12Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan 13Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan 14Department of Neuropsychiatry, Graduate school of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan 15University of New Mexico, Albuquerque, NM, USA 16Mind Research