Nitroglycerin
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Comparison of the Antiischaemic and Antianginal Effects of Nicorandil and Amlodipine in Patients with Symptomatic Stable Angina Pectoris: the SWAN Study
Journal of Clinical and Basic Cardiology An Independent International Scientific Journal Journal of Clinical and Basic Cardiology 1999; 2 (2), 213-217 Comparison of the antiischaemic and antianginal effects of nicorandil and amlodipine in patients with symptomatic stable angina pectoris: the SWAN study The SWAN Study Group Homepage: www.kup.at/jcbc Online Data Base Search for Authors and Keywords Indexed in Chemical Abstracts EMBASE/Excerpta Medica Krause & Pachernegg GmbH · VERLAG für MEDIZIN und WIRTSCHAFT · A-3003 Gablitz/Austria ORIGINAL PAPERS, CLINICAL The SWAN study J Clin Basic Cardiol 1999; 2: 213 Comparison of the antiischaemic and antianginal effects of nicorandil and amlodipine in patients with symptomatic stable angina pectoris: the SWAN study The SWAN Study Group1 This multicentre, double-blind, randomised study compared the antiischaemic and antianginal effects of nicorandil and amlodipine in patients with symptomatic stable angina pectoris. Nicorandil is a new coronary and balanced peripheral vasodilating agent that operates through two mechanisms of action: activation of ATP-dependent K-channels and stimulation of guanylate cyclase. A total of 121 patients with symptomatic stable angina pectoris were randomised to receive nicorandil 10 mg twice daily (bd) or amlodipine 5 mg once daily (od) for 8 weeks (optional dosage increase after 2-4 weeks to 20 mg bd and 10 mg od, respec- tively). Symptom-limited exercise tolerance tests were performed at baseline, and after 2 and 8 weeks treatment, respectively. In addition, the number of anginal attacks, nitroglycerin (NTG) usage, blood pressure (BP), heart rate (HR) and adverse events were recorded, and a subjective assessment of quality of life performed. -
Chelmsford-1958.Pdf (14.23Mb)
Jown of Chelmdtord ANNUAL REPORT FOR THE YEAR ENDING DECEMBER 31, 1958 Itt Hfomonam FIRE CHIEF ALLAN KIDDER Allan Kidder, Chief of the Fire Department, died on November 4, 1958. Chief Kidder was first appointed a call firefighter in 1931. After serving his country in World War II, he returned to the Fire Department in 1946 as a regular firefighter. He rose rapidly in rank until in 1954 he was appointed as Chelmsford's first full- time Fire Chief. His untimely passing put an end to a career dedicated to the Fire Service, a career in which he earned the respect of his fellow-workers and of the Townspeople. SULLIVAN BROS. LOWELL, MASS. ANNUAL REPORT OF THE ^Jown of CkeLsfoJ FOR THE YEAR ENDING DECEMBER 31, 1958 ANNUAL TOWN REPORT Report of the Town Clerk ELECTED TOWN OFFICIALS MODERATOR Edward J. Desaulnier, Jr. (Term Expires 1960) Resigned Jan. 13, 1959 TOWN CLERK Charlotte P. DeWolf (Term Expires 1960) SELECTMEN AND BOARD OF PUBLIC WELFARE Edgar P. George Term Expires 1959 Robert F. McAndrew Term Expires 1960 Raymond J. Greenwood Term Expires 1961 TREASURER AND TAX COLLECTOR Charlotte P. DeWolf, Temporary until Feb. 1959 Walter R. Wilkins, Jr. Term Expires 1960 BOARD OF ASSESSORS Warren Wright Term Expires 1959 John J. Dunigan - Term Expires 1960 Claude A. Harvey _ Term Expires 1961 TREE WARDEN Myles J. Hogan (Term Expires 1960) BOARD OF HEALTH William R. Greenwood _ Term Expires 1959 Edmund J. Welch Term Expires 1960 Oliver A. Reeves Term Expires 1961 8 ANNUAL TOWN REPORT SCHOOL COMMITTEE Allan R. Davidson Term Expires 1959 Henrick R. -
Dave's Decision: Whether to Weather
Volume 37, No. 5 June, 2008 PUBLISHED BY THE LIONEL® COLLECTORS CLUB OF AMERICA IN FEBRUARY, APRIL, JUNE, OCTOBER, DECEMBER Dave’s Decision: Whether to Weather The Lion Roars June, 2008 LAST CHANCE TO ORDER Deadline Imminent The Lionel Collectors Club of America offers these two This limited-edition production run will include these quality distinctive cars of the northeast region — “Susie Q” and Ontario features: Northland RR — to members as the 2008 Convention car. Limit: • produced by Lionel® exclusively for LCCA two sets per member. • die-cast, fully sprung trucks with rotating roller bearing caps; truck sideframes are painted to match the cars The Susquehanna car will include the classic rendering of the • roof hatches actually open and close “Susie Q” character never before presented on a hopper car. This • crisp graphics with SUSIE Q and ONR décor pair will appeal to Susie Q and Canadian model railroaders, niche • added-on (not molded-in) ladders and brake wheels collectors seeking rolling stock of northeastern regional railroads, • detailed undercarriage and collectors of LCCA Convention cars. • discrete LCCA 2008 Convention designation on the underside. Order Form for “Susie Q” and ONR Cars Once submitted, LCCA will consider this a firm, non-refundable order. Deadline for ordering: June 30, 2008. Note: UPS cannot deliver to a post office box. A street address is required. Name: ____________________________________________________________________ LCCA No.: ________________ Address: ____________________________________________________________________________________________ City: _____________________________________________________________ State: ____ Zip + 4: __________________ Phone: (______) ______________________ e-mail: __________________________________________________________ [ ] Check this box if any part of your address is new. Do the Math: [ ] Payment Plan A: My check for the full amount is enclosed made payable to 2008 LCCA Convention Car “LCCA” with “TLR/2008CC” written on the memo line. -
Sample Chapter Template for AFFA
The Training Material on “Dangerous Goods Handling (All modes)” has been produced under Project Sustainable Human Resource Development in Logistic Services for ASEAN Member States with the support from Japan-ASEAN Integration Fund (JAIF). Copyright Association of Southeast Asian Nations (ASEAN) 2014. All rights reserved. Dangerous Goods Handling Chapter 2: International Classification of Dangerous Goods Objectives This chapter will explain UN Transport regulations, its history and basis as model regulations for international classification system for other modes of transport. The linkage into the ASEAN Protocol 9 framework on the international carriage of dangerous goods in ASEAN will also be explained. 9 classes of dangerous goods classification shall be key content in this chapter. Other relevant basic terms such as Class, Division, Packaging Group (PG), UN Number (UNNO) and Proper Shipping Names (PSN) will also be covered. As supplement knowledge in classification of substances or mixtures that have more than one hazard, the explanation on precedence of hazard characteristics will be given. Basic hazard communication such as Labelling requirements, Dangerous Goods Declaration (DGD) or Multi-modal Dangerous Goods Form shall be explained. 1. Introduction 1.1 United Nations Recommendations on the Transport of Dangerous Goods (UNTDG/UNRTDG) These Recommendations have been developed by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods in the light of technical progress, the advent of new substances and materials, the exigencies of modern transport systems and, above all, the requirement to ensure the safety of people, property and the environment. They are addressed to governments and international organizations concerned with the regulation of the transport of dangerous goods. -
Trench Blasting with DYNAMITE a TRADITION of INNOVATION
Trench Blasting with DYNAMITE A TRADITION OF INNOVATION Dyno Nobel’s roots reach back to every significant in- novation in explosives safety and technology. Today, Dyno Nobel supplies a full line of explosives products and blasting services to mines, quarries and contractors in nearly every part of the world. DYNAMITE PRODUCT OF CHOICE FOR TRENCH BLASTING One explosive product has survived the test of time to become a true classic in the industry. DYNAMITE! The dynamite products manufactured today by Dyno Nobel are similar to Alfred Nobel’s original 1860s invention yet, in selected applications, they outperform any other commercial explosives on the market. The high energy, reliability and easy loading characteristics of dynamite make it the product of choice for difficult and demand- ing trench blasting jobs. Look to Unigel®, Dynomax Pro® and Unimax® to make trench blasting as effective and efficient as it can be. DISCLAIMER The information set forth herein is provided for informational purposes only. No representation or warranty is made or intended by DYNO NOBEL INC. or its affiliates as to the applicability of any procedures to any par- ticular situation or circumstance or as to the completeness or accuracy of any information contained herein. User assumes sole responsibility for all results and consequences. ® Cover photo depicts a trench blast using Primacord detonating cord, MS ® Connectors and Unimax dynamite. SAFE BLASTING REMINDERS Blasting safety is our first priority. Review these remind- ers frequently and make safety your first priority, too. • Dynamite products will provide higher energy value than alternate products used for trenching due to their superior energy, velocity and weight strength. -
Dangerous Goods Classifications
Dangerous Goods Classifications Dangerous Goods Classifications Click on a class to read more details: 1. Explosives 2. Gases 3. Flammable Liquids 4. Flammable Solids 5. Oxidizing Substances 6. Toxic & Infectious Substances 7. Radioactive Material 8. Corrosives 9. Miscellaneous Dangerous Goods CLASS 1: EXPLOSIVES Explosives are materials or items which have the ability to rapidly conflagrate or detonate as a consequence of chemical reaction. Subclass Subclass 1.1: Explosives with a mass explosion hazard Consists of explosives that have a mass explosion hazard. A mass explosion is one which affects almost the entire load instantaneously. Subclass 1.2: Explosives with a severe projection hazard Consists of explosives that have a projection hazard but not a mass explosion hazard. Subclass 1.3: Explosives with a fire Consists of explosives that have a fire hazard and either a minor blast hazard or a minor projection hazard or both but not a mass explosion hazard. Subclass 1.4: Minor fire or projection hazard Consists of explosives that present a minor explosion hazard. The explosive effects are largely confined to the package and no projection of fragments of appreciable size or range is to be expected. An external fire must not cause virtually instantaneous explosion of almost the entire contents of the package. Subclass 1.5: An insensitive substance with a mass explosion hazard Consists of very insensitive explosives with a mass explosion hazard (explosion similar to 1.1). This division is comprised of substances which have a mass explosion hazard but are so insensitive that there is very little probability of initiation or of transition from burning to detonation under normal conditions of transport. -
Nitroglycerin Sublingual Tablets, USP)
NDA 021134/S-004 Page 4 Nitrostat® (Nitroglycerin Sublingual Tablets, USP) DESCRIPTION Nitrostat is a stabilized sublingual compressed nitroglycerin tablet that contains 0.3 mg , 0.4 mg , or 0.6 mg nitroglycerin; as well as lactose monohydrate, NF; glyceryl monostearate, NF; pregelatinized starch, NF; calcium stearate, NF powder; and silicon dioxide, colloidal, NF. Nitroglycerin, an organic nitrate, is a vasodilating agent. The chemical name for nitroglycerin is 1, 2, 3 propanetriol trinitrate and the chemical structure is: NO2 O O N O CH2CHCH2 O NO 2 2 C3H5N309 Molecular weight: 227.09 CLINICAL PHARMACOLOGY The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation of postcapillary vessels, including large veins, promotes peripheral pooling of blood, decreases venous return to the heart, and reduces left ventricular end-diastolic pressure (preload). Nitroglycerin also produces arteriolar relaxation, thereby reducing peripheral vascular resistance and arterial pressure (afterload), and dilates large epicardial coronary arteries; however, the extent to which this latter effect contributes to the relief of exertional angina is unclear. Therapeutic doses of nitroglycerin may reduce systolic, diastolic, and mean arterial blood pressure. Effective coronary perfusion pressure is usually maintained, but can be compromised if blood pressure falls excessively, or increased heart rate decreases diastolic filling time. Elevated central venous and pulmonary capillary wedge pressures, and pulmonary and systemic vascular resistance are also reduced by nitroglycerin therapy. Heart rate is usually slightly increased, presumably due to a compensatory response to the fall in blood pressure. -
DITTMAR V. RIX and ANOTHER. Circuit Court, S
DITTMAR V. RIX AND ANOTHER. Circuit Court, S. D. New York. March 13, 1880. PATENT—COMPOUND MADE BY PATENTED PROCESS.—A patent containing two claims, the one for a certain process set forth, and the other for a certain compound made by the process set forth, is not infringed by the manufacture of a similar compound, not made by the patented process. Motion for preliminary injunction to restrain the infringement of letters patent. Everett P. Wheeler and Clarence Lexow, for plaintiff. George Gifford and Causten Browne, for defendants. BLATCHFORD, J. This is a motion for a preliminary injunction to restrain the infringement of letters patent granted to the plaintiff, January 18, 1870, for an “improvement in explosive compounds.” The specification states that the patentee has invented an explosive agent which he calls “Dualin, and which is to be used instead of other explosive agents, such as powder, gun-cotton, nitro-glycerine, dynamite, etc.” It proceeds: “Dualin is a yellowish brown powder, resembling in appearance Virginia smoking tobacco. It will, if lighted in the open air, burn without exploding; but, if confined, it may be made to explode in the same manner as common 343 powder. It is not sensitive to concussion, will not decompose by itself, not cake or pack together, may be readily filled into cartridges, and it matters not whether the place where it is stored be warm or cold, dry or damp. Dualin has from four to ten times the strength of common powder, and is stronger than dynamite, an improvement on nitro-glycerine. Some of the -
2,4,6-Trinitrotoluene (Tnt)
2,4,6-TRINITROTOLUENE (TNT) What is 2,4,6-TRINITROTOLUENE? 2,4,6-trinitrotoluene, also called TNT, is a man-made compound. The odorless, yellow solid is used in explosives. In the United States, TNT is primarily made at military sites. Where can TNT be found and how is it used? TNT is an explosive used by the military in artillery shells, grenades and airborne bombs. TNT may be found in old artillery shells that wash up or are dredged up on beaches. Industries use TNT to make dye and photography chemicals. How can people be exposed to TNT? You could be exposed to TNT through: Breathing vapor or dust containing TNT. This might happen if your work involves TNT. Drinking water polluted with TNT. This could happen if you drink water polluted by a waste site containing TNT. Eating fruits and vegetables grown in soil containing TNT. Touching soil that contacted TNT. You can also touch it if you work with TNT. Eye Contact by touching the eyes with hands contaminated with TNT, or getting TNT-contaminated dust in them. How does TNT work? When you breathe in air or drink water with TNT in it, the chemical enters your body quickly and completely. If TNT touches the skin, the body absorbs it more slowly. Regardless of the type of exposure, TNT is absorbed by the bloodstream and travels to the organs. When it reaches the liver, it breaks down and changes into several different substances. Not all of these substances have been identified, so it is not known if they are harmful. -
1 English 467 Professor Anne Fadiman by Submitting This Essay, I
English 467 Professor Anne Fadiman By submitting this essay, I attest that it is my own work, completed in accordance with University regulations. Paul Gleason Breaking Rock by Paul Gleason Dino pulls a brass plunger, thick as a screwdriver, off his belt and punches a hole in the yellow-tissue-covered stick of dynamite. He then replaces the plunger with a small cylindrical blasting cap. The late October cold makes the Blasting Gelatin stiff, he explains, raising his voice over the sound of shattering rock coming from under Donnie’s drilling machine. If he tried to shove the blasting cap right in, it might break, and if it broke—“all over,” he says, grinning broadly and waving a hand in circles around his face and chest. “Blood and guts all over you.” Together, the blasting cap and dynamite make a charge. The cap connects to an orange “shock tube,” full of a powder that burns at a rate of three miles per second. Several charges linked together make a shot. Dino drops the charge down one of Donnie’s thirteen-foot holes, letting the tube run between his fingers until it goes slack. He picks up the sixteen-foot-tall pole lying on the ground; it has black circles and numbers marking every foot. He steadily lowers it into the hole and taps the dynamite into place. This is the first of eight holes, eight charges that will go off as one shot. Cox Drilling and Blasting, Dino and Donnie’s employer, is one of several companies working at 18 Temple Street, a 200’-by-100’ lot in the middle of downtown Hartford. -
Chapter 2 EXPLOSIVES
Chapter 2 EXPLOSIVES This chapter classifies commercial blasting compounds according to their explosive class and type. Initiating devices are listed and described as well. Military explosives are treated separately. The ingredi- ents and more significant properties of each explosive are tabulated and briefly discussed. Data are sum- marized from various handbooks, textbooks, and manufacturers’ technical data sheets. THEORY OF EXPLOSIVES In general, an explosive has four basic characteristics: (1) It is a chemical compound or mixture ignited by heat, shock, impact, friction, or a combination of these conditions; (2) Upon ignition, it decom- poses rapidly in a detonation; (3) There is a rapid release of heat and large quantities of high-pressure gases that expand rapidly with sufficient force to overcome confining forces; and (4) The energy released by the detonation of explosives produces four basic effects; (a) rock fragmentation; (b) rock displacement; (c) ground vibration; and (d) air blast. A general theory of explosives is that the detonation of the explosives charge causes a high-velocity shock wave and a tremendous release of gas. The shock wave cracks and crushes the rock near the explosives and creates thousands of cracks in the rock. These cracks are then filled with the expanding gases. The gases continue to fill and expand the cracks until the gas pressure is too weak to expand the cracks any further, or are vented from the rock. The ingredients in explosives manufactured are classified as: Explosive bases. An explosive base is a solid or a liquid which, upon application or heat or shock, breaks down very rapidly into gaseous products, with an accompanying release of heat energy. -
1 SAFETY DATA SHEET Product Name: Nitroglycerin in 5% Dextrose
SAFETY DATA SHEET Product Name: Nitroglycerin in 5% Dextrose Injection 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Manufacturer Name And Hospira, Inc. Address 275 North Field Drive Lake Forest, Illinois 60045 USA Emergency Telephone CHEMTREC: North America: 800-424-9300; International 1-703-527-3887; Australia - 61-290372994; UK - 44-870-8200418 Hospira, Inc., Non-Emergency 224 212-2000 Product Name Nitroglycerin in Dextrose Injection Synonyms 1,2,3-propanetriol trinitrate 2. HAZARD(S) IDENTIFICATION Emergency Overview Nitroglycerin in Dextrose Injection is a solution containing nitroglycerin, an organic nitrate vasodilator. Clinically, this material is indicated for treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris. In the workplace, this material should be considered potentially irritating to the eyes and respiratory tract and a potent drug. Based on clinical use, possible target organs include the cardiovascular system and blood. U.S. OSHA GHS Classification Physical Hazards Hazard Class Hazard Category Not Classified Not Classified Health Hazards Hazard Class Hazard Category Not Classified Not Classified Label Element(s) Pictogram NA Signal Word NA Hazard Statement(s) NA Precautionary Statement(s) Prevention Do not breathe vapor or spray. Wash hands thoroughly after handling. Response Get medical attention if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical attention. 1 Product Name: Nitroglycerin in 5% Dextrose Injection 3. COMPOSITION/INFORMATION ON INGREDIENTS Active Ingredient Name Nitroglycerin Chemical Formula C3H5N3O9 Component Approximate Percent by Weight CAS Number RTECS Number Nitroglycerin ≤ 0.04 55-63-0 QX2100000 Non-hazardous ingredients include Water for Injection and dextrose.