CYTOCHROME P450 Biochemistry, Biophysics and Molecular Biology
8th International Conference Lisbon, Portugal 24-28 October 1993 CYTOCHROME P450 Biochemistry, Biophysics and Molecular Biology Edited by: Gulbenkian Institute of Science JohnLibbey ra JEUROTEXT CONTENTS V Preface VII Committee VIII Acknowledgements IX Foreword EVOLUTION AND PHYLOGENETIC DIVERSITY OF P450 GENES 3 Evolutionary argument for a connection between drug metabolism and signal transaction. D.W. NEBERT, R. FEYEREISEN 15 Hierarchical clustering and proposed classification of the P450 superfamily using consensus sequences. A.I. ARCHAKOV, K.N. DEGTYARENKO 23 Function and diversity of plant cytochrome P450. F. DURST, I. BENVENISTE, J.-P. SALAUN, D. WERCK 31 Insect cytochrome P450: functions, regulation and diversify. R. FEYEREISEN, J.F. ANDERSEN, F.A. CARINO, M.B. COHEN, J.F. KOENER, S. REPECKO, J.A SCOTT, M.J. SNYDER 37 The role of conserved 5'-flanking (Barbie Box) DNA sequences and barbi- turate-responsive DNA-binding proteins in the mechanism of induction by barbiturates of P450 cytochromes in Bacillus megaterium and other proka- ryotic and eukaryotic organisms. A.J. FULCO, J.-S. HE, Q. LIANG 43 Nitric oxide synfhase: mechanisms and relationship to cytochrome P450. K.A. WHITE, R.A. PUFAHL, N.M. OLKEN, J.M. HEVEL, M.K. RICHARDS, M.A. MARLETTA XI II CONTROL MECHANISMS I—-I IN THE BIOGENESIS OF CYTOCHROME P450'S 51 Growth hormone regulation of liver sexual differentiation. J.A. GUSTAFSSON, P. TOLLET, A. MODE 59 Mechanisms of liver-specific expression of the CYP2D5 gene. Y.-H. LEE, F.J. GONZALEZ 67 Expression and function of Ad4BP, a steroidogenic cell-specific transcrip- tion factor. K.-l. MOROHASHI, S.-l.
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