molecules Review The Genus Haplophyllum Juss.: Phytochemistry and Bioactivities—A Review Majid Mohammadhosseini 1,* , Alessandro Venditti 2 , Claudio Frezza 3,* , Mauro Serafini 3, Armandodoriano Bianco 2 and Behnam Mahdavi 4 1 Department of Chemistry, College of Basic Sciences, Shahrood Branch, Islamic Azad University, Shahrood 3616713455, Iran 2 Dipartimento di Chimica, Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy;
[email protected] (A.V.);
[email protected] (A.B.) 3 Dipartimento di Biologia Ambientale, Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy; mauro.serafi
[email protected] 4 Department of Chemistry, Faculty of Science, Hakim Sabzevari University, Sabzevar 9617976487, Iran;
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[email protected] (C.F.) Abstract: Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (EOs), non-volatile compounds, ethnobotany, and biological activities of different Haplophyllum (Rutaceae family) species. To gather the relevant data, all the scientific databases, including Scopus, ISI-WOS (Institute of Scientific Information-Web of Science), and PubMed and highly esteemed publishers such as Elsevier, Springer, Taylor and Francis, etc., were systematically retrieved and reviewed. A wide array of valuable groups of natural compounds, e.g., terpenoids, coumarins, Citation: Mohammadhosseini, M.; alkaloids, lignans, flavonoids, and organic acids have been isolated and subsequently characterized Venditti, A.; Frezza, C.; Serafini, M.; in different organic extracts of a number of Haplophyllum species. In addition, some remarkable Bianco, A.; Mahdavi, B. The Genus antimicrobial, antifungal, anti-inflammatory, anticancer, cytotoxic, antileishmanial, and antialgal Haplophyllum Juss.: Phytochemistry effects as well as promising remedial therapeutic properties have been well-documented for some and Bioactivities—A Review.