ClinicalTrials.gov Search Results 06/24/2020

Title Status Study Results Conditions Interventions Locations 1 A Study to Evaluate AP-101 in Familial and Sporadic Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: AP-101 •Kaye Edmonton Clinic, University of Alberta, Edmonton, Alberta, Amyotrophic Lateral Sclerosis (ALS) Canada •London Health Sciences Centre, University , London, Ontario, Canada •Sunnybrook Health Sciences Centre, Toronto, Toronto, Ontario, Canada •Montreal Neurological Institute & Hospital, Montréal, Quebec, Canada 2 Trial of Amivita in Amyotrophic Lateral Sclerosis Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Drug: Amivita •Wujing People's Hospital, Changzhou, Jiangsu, China 3 Amyotrophic Lateral Sclerosis: a New Paradigm Completed No Results Available •Amyotrophic Lateral Sclerosis •Genetic: ALS patients genetic •Centro Hospitalar Tras-os-Montes e Alto Douro, Vila Real, characterization Portugal •Other: ALS patients epidemiological caracterization 4 Safety and Tolerability of High Dose Biotin in Patients With Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Biotin •American univeristy of Beirut medical center, Beirut, Lebanon Amyotrophic Lateral Sclerosis •Drug: Placebo Oral Tablet 5 Rehabilitative Trial With tDCS in Amyotrophic Lateral Completed Has Results •Amyotrophic Lateral Sclerosis •Device: Anodal bilateral motor cortex and •AO Spedali Civili, Brescia, BS, Italy Sclerosis cathodal spinal tDCS •Device: Sham bilateral motor cortex and sham spinal tDCS 6 A Registered Cohort Study on Amyotrophic Lateral Sclerosis Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Department of Neurology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China 7 Trial of Safety, Tolerability and Efficacy of Trametinib Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Trametinib (0.5 mg) •Asan Medical Center, Seoul, Korea, Republic of (SNR1611) in Patients With Amyotrophic Lateral Sclerosis •Drug: Trametinib (1 mg) •Korea University Anam Hospital, Seoul, Korea, Republic of (ALS) •Drug: Trametinib (2 mg) •Samsung Medical Center, Seoul, Korea, Republic of •Drug: Riluzole (100 mg) •Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of 8 Exploratory Study of Biotelemetry in Amyotrophic Lateral Completed Has Results •Amyotrophic Lateral Sclerosis •Device: Faros Sensor (FS) and LifeInsight •GSK Investigational Site, London, United Kingdom Sclerosis Hub •GSK Investigational Site, Oxford, United Kingdom •Device: Fast Fix electrode patch •Procedure: Quantitative Measure of Speech (Core Phase Only) 9 The National Amyotrophic Lateral Sclerosis Registry Recruiting No Results Available •Amyotrophic Lateral Sclerosis •CDC, Atlanta, Georgia, United States 10 Compassionate Treatment : An Exploratory Clinical Trial to Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Autologous Adipose-Tissue •China Medical University Beigang Hospital, Beigang, Yunlin, Assess Treatment of Amyotrophic Lateral Sclerosis Derived Stem Cells Taiwan 11 Study of Cognitive and Emotional Disorders in Amyotrophic Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: MRI + 18FDG-PET + •University Hospital Center, Caen, France Lateral Sclerosis neuropsychological assessments ; 18FDG •University Hospital Center, Rouen, France performed especially for the research 12 Repetitive Transcranial Magnetic Stimulation as Therapy for Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Device: rTMS •Jagiellonian University Medical College, Department of Apathy in Amyotrophic Lateral Sclerosis Neurology, Kraków, Poland 13 Transcranial Static Magnetic Field Stimulation (tSMS) in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Device: tSMS •Department of Neurology and Laboratory of Neuroscience, Amyotrophic Lateral Sclerosis (ALS). Istituto Auxologico Italiano, IRCCS, Milan, Italy •Device: sham tSMS •Neurology Unit, Campus Biomedico University, Rome, Italy

- Page 1 of 12 - Title Status Study Results Conditions Interventions Locations 14 Colchicine for Amyotrophic Lateral Sclerosis Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Colchicine 1 MG Oral Tablet •Centro Sla, University of Bari, Bari, Italy •Drug: Placebo Oral Tablet •Centro Sla, Istituto Auxologico Italiano, University of Milano, Milano, Milano, Italy •Irccs Carlo Besta, Milano, Italy •Irccs St. Raffaele Institute of Milano, Milano, Italy •Centro Sla, Ospedale Civile S. Agostino Estense, A.O.U. Modena, Modena, Italy •Università della Campania Gianluigi Vanvitelli, Napoli, Italy •Centro Sla, Universita' Di Padova, Padova, Italy •Als Centre, "C. Mondino" National Neurological Institute, University of Pavia, Pavia, Italy •, Neuromuscular Omnicentre Centre, Rome, Catholic University, Rome, Roma, Italy •Centro Sla, Universita' Di Torino, Torino, Italy 15 Epidemiology and Genetics of the Amyotrophic Lateral Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Dietary Supplement: Blood sample and •Hospital University Center of Pointe-à-Pitre, Pointe-à-Pitre, Sclerosis in the French West Indies environmental survey Guadeloupe •Hospital University Center of Martinique, Fort-de-France, Martinique 16 In-situ Cytokines Expression in the CNS in Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Other: in-situ cytokine expression •CHU Brugmann, Brussels, Belgium Lateral Sclerosis (ALS) 17 Virtual Task in Amyotrophic Lateral Sclerosis Completed No Results Available •Amyotrophic Lateral Sclerosis •Device: Acquisition on TouchScreen •Escola de Artes,Ciencias e Humanidades da Universidade d Sao Paulo, Sao Paulo, Brazil •Device: Acquisition on Kinect •Device: Acquisition on LeapMotion •Device: Acquisition on TouchScreen Control Group •Device: Acquisition on Kinect Control Group •Device: Acquisition on LeapMotion Control Group 18 Muscular Biomarkers in Amyotrophic Lateral Sclerosis Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Other: Samples •Service de chirurgie orthopédique et traumatologique, CHRU de TOURS, Tours, France •Service de Neurologie, CHRU de TOURS, Tours, France 19 HERV-K Suppression Using Antiretroviral Therapy in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Darunavir •National Institutes of Health Clinical Center, 9000 Rockville Volunteers With Amyotrophic Lateral Sclerosis (ALS) Pike, Bethesda, Maryland, United States •Drug: Ritonavir •Drug: dolutegravir •Drug: Tenofovir alafenamide (TAF) 20 Repetitive Transcranial Magnetic Stimulation as Therapy for Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Device: active repetitive transcranial •Jagiellonian University Medical College, Department of Depression in Amyotrophic Lateral Sclerosis magnetic stimulation Neurology, Kraków, Poland •Device: sham repetitive transcranial magnetic stimulation

- Page 2 of 12 - Title Status Study Results Conditions Interventions Locations 21 A Study to Evaluate Efficacy, Safety and Tolerability of Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: CK-2127107 •St. Joseph's Hospital and Medical Center - Barrow Neurological CK-2127107 in Patients With Amyotrophic Lateral Sclerosis Clinics, Phoenix, Arizona, United States •Drug: Placebo (ALS) •Cedars-Sinai Medical Center, Los Angeles, California, United States •University of California Irvine, Orange, California, United States •Forbes Norris MDA/ALS Research Center, San Francisco, California, United States •Stanford Hospital and Clinics, Stanford, California, United States •University of Colorado Hospital Anschutz Outpatient Pavilion, Aurora, Colorado, United States •Hospital for Special Care, New Britain, Connecticut, United States •George Washington University Medical Faculty Associates, Washington, District of Columbia, United States •University of Florida, Gainesville, Florida, United States •, Jacksonville, Florida, United States •and 54 more 22 Bioenergetics and Protein Metabolism in Sporadic Unknown status No Results Available •Sporadic Amyotrophic Lateral Sclerosis •Other: Skin Biopsy Amyotrophic Lateral Sclerosis 23 Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Biological: Stem Cell •Neurogen brain and spine institute, Navi Mumbai, Maharashtra, Sclerosis India 24 Influence of the Vitamin D Blood Levels on the Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Blood test •UH Montpellier, Montpellier, France Lateral Sclerosis Phenotype 25 Amyotrophic Lateral Sclerosis Web Based Patient Care Completed No Results Available •Amyotrophic Lateral Sclerosis •Behavioral: ALS Registry •Forbes Norris MDA/ALS Center, San Francisco, California, Database: ALSConnection.Org United States 26 Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Peking University Third Hospital, Beijing, Beijing, China Mainland China 27 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Not yet recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Gold Nanocrystals •UT Southwestern, Dallas, Texas, United States Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) 28 Quantitative Neuromuscular Ultrasonography in Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Universidad Católica San Antonio de Murcia, Guadalupe, Lateral Sclerosis (ALS) Murcia, Spain 29 Clenbuterol on Motor Function in Individuals With Amyotrophic Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Clenbuterol •Duke University Medical center, Durham, North Carolina, United Lateral Sclerosis States 30 Identification of Diagnostic And Prognostic Biomarkers From Completed No Results Available •Amyotrophic Lateral Sclerosis •Carolinas Neuromuscular/ALS-MDA care Center, Charlotte, Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose North Carolina, United States Samples 31 Phase 3 Study of MCI-186 for Treatment of Amyotrophic Completed Has Results •Amyotrophic Lateral Sclerosis (ALS) •Drug: MCI-186 •Osaka, Japan Lateral Sclerosis •Drug: Placebo •Drug: MCI-186 in open label phase 32 Biomarkers in Different Types of Amyotrophic Lateral Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Other: Sample Collection •Loma Linda University, Loma Linda, California, United States Sclerosis (ALS) Patients Being Treated With Edaravone 33 Safety and Tolerability Ultra-high-caloric Food Supplements in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Dietary Supplement: high-caloric fatty diet •University of Ulm, Department of Neurology, Ulm, Baden- Amyotrophic Lateral Sclerosis (ALS) Wurttemberg, Germany •Dietary Supplement: ultra-high-caloric fatty diet •Dietary Supplement: ultra-high-caloric carbohydrate-rich diet 34 Pharyngeal Electrical Stimulation in Amyotrophic Lateral Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Device: Pharyngeal Electrical Stimulation •University of Ulm, Ulm, Germany Sclerosis

- Page 3 of 12 - Title Status Study Results Conditions Interventions Locations 35 The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Dietary Supplement: Tocotrienols •Clinical Investigation Centre (CIC), Kuala Lumpur, Malaysia Patients With Amyotrophic Lateral Sclerosis (ALS) •Dietary Supplement: Placebo 36 Effects of Nocturnal Non-invasive Ventilation in Patients With Completed No Results Available •Amyotrophic Lateral Sclerosis •Device: non-invasive ventilation •Peilin Lee, Taipei, Taiwan Amyotrophic Lateral Sclerosis 37 Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis Completed No Results Available •Amyotrophic Lateral Sclerosis •Biological: VM202 •Northwestern University, Chicago, Illinois, United States 38 Fecal Microbiota Transplantation Effect on Amyotrophic Not yet recruiting No Results Available •Amyotrophic Lateral Sclerosis •Biological: Fecal microbiota transplantation •Clinica Neurologica, Ospedale Clinicizzato "SS Annunziata", Lateral Sclerosis Patients Chieti, Italy •Biological: Placebo •Azienda Ospedaliero Universitaria Careggi, Firenze, Italy •Azienda Ospedaliero Universitaria di Modena, Modena, Italy •UO Neurofisiopatologia, Azienda Ospedaliera dì Perugia, Perugia, Italy •Institute of Neurology, Policlinico Campus Bio-medico, Roma, Italy •NEuroMuscular Omnicentre Centre (NeMO), Fondazione Serena Onlus-Fondazione Policlinico A. Gemelli, Roma, Italy 39 Aerobic Exercise Training in Amyotrophic Lateral Sclerosis Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: Aerobic exercise training •Fondazione Salvatore Maugeri, IRCCS - Scientific Institute of Veruno, Veruno, Italy •Other: Standard physical therapy (Stretching/Range-of-motion) 40 A Study to Explore the Safety and Tolerability of Acthar in Completed Has Results •Amyotrophic Lateral Sclerosis •Drug: Repository corticotropin injection •Questcor Investigational Site, Birmingham, Alabama, United Patients With Amyotrophic Lateral Sclerosis States •Questcor Investigational Site, Phoenix, Arizona, United States •Questcor Investigational Site, San Francisco, California, United States •Questcor Investigational Site, Stanford, California, United States •Questcor Investigational Site, Jacksonville, Florida, United States •Questcor Investigational Site, Miami, Florida, United States •Questcor Investigational Site, Tampa, Florida, United States •Questcor Investigational Site, Atlanta, Georgia, United States •Questcor Investigational Site, Kansas City, Kansas, United States •Questcor Investigational Site, Rochester, Minnesota, United States •and 7 more 41 Multidisciplinary Follow-up of Patients With Amyotrophic Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: no intervention •Geneva University Hospital, Geneva, Switzerland Lateral Sclerosis 42 Randomized, Double-blind, Safety and Efficacy of Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: recombinant human •Hanyang Medical Center, Seoul, Korea, Republic of Recombinant Human Erythropoietin in Amyotrophic Lateral erythropoietin(rhEPO) Sclerosis 43 Optic Coherence Tomography in Patients With Amyotrophic Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Diagnostic Test: Optic coherence Lateral Sclerosis tomography •Diagnostic Test: Pulmonary function test 44 Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate Completed Has Results •Amyotrophic Lateral Sclerosis •Dept. of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany 45 Perampanel Single Ascending Dose Transcranial Magnetic Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Perampanel •Mayo Clinic, Jacksonville, Florida, United States Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis •Other: Placebo

- Page 4 of 12 - Title Status Study Results Conditions Interventions Locations 46 Safety of Urate Elevation in Amyotrophic Lateral Sclerosis Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Inosine •Holy Cross Hospital, Fort Lauderdale, Florida, United States (ALS) •Drug: Placebo •Massachusetts General Hospital, Boston, Massachusetts, United States •University of Minnesota, Minneapolis, Minnesota, United States 47 Riluzole Oral Soluble Film Swallowing Safety in Amyotrophic Terminated No Results Available •Amyotrophic Lateral Sclerosis •Drug: Riluzole Oral Soluble film (ROSF) 50 •University of Florida Center for Movement Disorders & Lateral Sclerosis mg Neuroscience, Gainesville, Florida, United States 48 Safety and Tolerability of Perampanel in Amyotrophic Lateral Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Fycompa •Johnny S. Salameh, Beirut, Lebanon Sclerosis Patients 49 Study to Evaluate DNL747 in Subjects With Amyotrophic Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: DNL747 •Bioclinica, Orlando, Florida, United States Lateral Sclerosis •Drug: Placebo •PRA Health Sciences, Salt Lake City, Utah, United States •CHDR, Leiden, South Holland, Netherlands 50 Therapeutic Treatment of Amyotrophic Lateral Sclerosis Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: Biological: Cell-based therapy 51 Study of Ozanezumab (GSK1223249) Versus Placebo in the Completed Has Results •Amyotrophic Lateral Sclerosis •Drug: Ozanezumab •GSK Investigational Site, Boston, Massachusetts, United States Treatment of Amyotrophic Lateral Sclerosis •Drug: Placebo •GSK Investigational Site, Grand Rapids, Michigan, United States •GSK Investigational Site, Syracuse, New York, United States •GSK Investigational Site, Columbus, Ohio, United States •GSK Investigational Site, Randwick, New South Wales, Australia •GSK Investigational Site, Herston, Queensland, Australia •GSK Investigational Site, Leuven, Belgium •GSK Investigational Site, Calgary, Alberta, Canada •GSK Investigational Site, London, Ontario, Canada •GSK Investigational Site, Toronto, Ontario, Canada •and 25 more 52 Nebulized RNS60 for the Treatment of Amyotrophic Lateral Not yet recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: RNS60 Sclerosis •Drug: Placebo 53 Resting Energy Expenditure Equations in Amyotrophic Lateral Completed No Results Available •Amyotrophic Lateral Sclerosis •Other: nutritional assessement •CHU LImoges, Limoges, France Sclerosis, Creation of a ALS-specific Equation 54 A Study to Evaluate the Safety, Tolerability and Efficacy of ILB Terminated No Results Available •Amyotrophic Lateral Sclerosis •Drug: ILB •Sahlgrenska University Hospital, Gothenburg, Sweden in Patients With Amyotrophic Lateral Sclerosis 55 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: BIIB100 •Barrow Neurological Institute, Phoenix, Arizona, United States and Pharmacodynamics of BIIB100 Administered Orally to •Drug: Placebo •University of California San Diego Medical Center, San Diego, Adults With Amyotrophic Lateral Sclerosis California, United States •Mayo Clinic Hospital, Jacksonville, Florida, United States •University of South Florida, Tampa, Florida, United States •Johns Hopkins University, Dept of Neurology, Baltimore, Maryland, United States •Research Site, Boston, Massachusetts, United States •Research Site, Saint Louis, Missouri, United States •Research Site, Lincoln, Nebraska, United States •Alliance for Multispecialty Research NOCCR/VRG, Knoxville, Tennessee, United States

- Page 5 of 12 - Title Status Study Results Conditions Interventions Locations 56 Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: SB-509 •Coordinated Clinical Research, La Jolla, California, United Sclerosis (ALS) States •University of California, Irvine; MDA ALS and Neuromuscular Center,, Orange, California, United States •California Pacific Medical Center (CPMC), The Forbes Norris MDA/ALS Research Center, San Francisco, California, United States •The University of Kansas Medical Center (KU), Kansas City, Kansas, United States •Johns Hopkins University, Baltimore, Maryland, United States •Nerve and Muscle Center of Texas, Houston, Texas, United States 57 Effect of Lithium Carbonate in Patients With Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: lithium •Pitié-Salpêtrière Hospital, Paris, France Lateral Sclerosis 58 A Study to Assess the Safety, Tolerability, and Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: BIIB078 •Research Site, La Jolla, California, United States Pharmacokinetics of BIIB078 in Adults With C9ORF72- •Drug: Placebo •Research Site, Los Angeles, California, United States Associated Amyotrophic Lateral Sclerosis •Research Site, Palo Alto, California, United States •Research Site, Jacksonville, Florida, United States •Research Site, Miami, Florida, United States •Research Site, Atlanta, Georgia, United States •Research Site, Baltimore, Maryland, United States •Research Site, Boston, Massachusetts, United States •Research Site, Saint Louis, Missouri, United States •Research Site, Lincoln, Nebraska, United States •and 10 more 59 Study of Rasagiline in Patients With Amyotrophic Lateral Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Rasagiline •Department of Neurology, University of Ulm, Ulm, Baden- Sclerosis Württemberg, Germany •Drug: Placebo •Department of Neurology, Technische Universität München, Muenchen, Bayern, Germany •Department of Neurology, Universty of Regensburg, Regensburg, Bayern, Germany •Department of Neurology, University of Wuerzburg, Wuerzburg, Bayern, Germany •Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Hessen, Germany •Department of Neurology, University of Rostock, Rostock, Mecklenburg-Vorpommern, Germany •Department of Neurology, University of Goettingen, Goettingen, Niedersachsen, Germany •Department of Neurology, Medical School Hannover, Hannover, Niedersachsen, Germany •Neurologische Universitätsklinik Bergmannsheil, Bochum, Nordrhein-Westfalen, Germany •Department of Neurology, Universty of Muenster, Muenster, Nordrhein-Westfalen, Germany •and 5 more 60 Conservative Iron Chelation as a Disease-modifying Strategy Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Deferiprone •Hôpital Roger Salengro, CHU, Lille, France in Amyotrophic Lateral Sclerosis •Drug: Placebo Oral Tablet

- Page 6 of 12 - Title Status Study Results Conditions Interventions Locations 61 A Long-term Extension Study of TCH346 and Placebo Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: TCH346 •Novartis, East Hanover, New Jersey, United States Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis(ALS) 62 Extension Study of Talampanel for Amyotrophic Lateral Terminated No Results Available •Amyotrophic Lateral Sclerosis •Drug: Talampanel Sclerosis (ALS) 63 Study of Acthar® Gel (Acthar) for Amyotrophic Lateral Terminated No Results Available •Amyotrophic Lateral Sclerosis •Drug: Acthar •Neuromuscular Research Center, Phoenix, Arizona, United Sclerosis (ALS) States •Drug: Placebo •Mayo Clinic - Arizona, Scottsdale, Arizona, United States •University of California San Diego, La Jolla, California, United States •Loma Linda University Health System, Department of Neurology, Loma Linda, California, United States •Keck School of Medicine, University of Southern California, Los Angeles, California, United States •University of California Los Angeles, Los Angeles, California, United States •University of California Irvine Medical Center, Orange, California, United States •California Pacific Medical Center, San Francisco, California, United States •University of California San Francisco, San Francisco, California, United States •Colorado Springs Neurological Associates, Colorado Springs, Colorado, United States •and 59 more 64 Tongue Strength in Amyotrophic Lateral Sclerosis (ALS) Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Device: medical device •Service ORL Assistance Publique Hôpitaux de Marseille, Marseille, France 65 NeuRx Diaphram Pacing System (DPS) Use in Amyotrophic Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Device: NeuRx DPS Lateral Sclerosis (ALS) 66 Blood-Brain Barrier Opening Using MR-Guided Focused Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Device: Blood-Brain Barrier opening with •Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Ultrasound in Patients With Amyotrophic Lateral Sclerosis MRgFUS 67 Transplantation of Autologous Peripheral Blood Mononuclear Completed No Results Available •Amyotrophic Lateral Sclerosis •Biological: PBMC autotransplantation •The First Affiliated Hospital of Dalian Medical University, Dalian, Cells for Amyotrophic Lateral Sclerosis Liaoning, China

- Page 7 of 12 - Title Status Study Results Conditions Interventions Locations 68 Accurate Screening Tools for Dysphagia in Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Device: Micro Mouth Pressure Meter •University of Florida, Gainesville, Florida, United States Lateral Sclerosis (ALS) •Device: Iowa Oral Performance Instrument •Device: Electrical Impedance Myography •Drug: Capsaicin •Procedure: Videofluoroscopic Swallowing Study •Procedure: Pulmonary Function Testing •Other: Swallowing Related Quality of Life Questionnaire •Other: Functional Oral Intake Scale •Other: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised •Other: Eating Assessment Tool-10 •Other: Communicative Effectiveness Survey •Other: The Center for Neurologic Studies Bulbar Function Scale 69 Autologous Bone Marrow Mesenchymal Stem Cells in the Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: Biological: Cell-based therapy Treatment of Patients With Amyotrophic Lateral Sclerosis 70 Respiratory Strength Training in Persons With Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Device: PowerLung trainer •UF Health Shands, Gainesville, Florida, United States Lateral Sclerosis (ALS) •Device: Micro Mouth Pressure Meter •Procedure: Pulmonary Function Testing •Procedure: Videofluoroscopic swallowing study •Other: Swallowing Quality of Life Questionnaire •Device: Iowa Oral Pressure Instrument •Drug: Capsaicin 71 Study of Gene Polymorphisms Involved in the Metabolism and Completed No Results Available •Amyotrophic Lateral Sclerosis •CHU de Montpellier - Hôpital Gui de Chauliac, Montpellier Action of Vitamin D in Amyotrophic Lateral Sclerosis Cedex 5, France 72 Efficacy and Safety of Plasma Exchange With Albutein® 5% in Completed No Results Available •Amyotrophic Lateral Sclerosis •Biological: Albutein 5% •Dartmouth-Hitchcock Medical Center, Lebanon, New Patients With Amyotrophic Lateral Sclerosis Hampshire, United States 73 Biological Treatment of Amyotrophic Lateral Sclerosis Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: Biological: Cell-based therapeutics •Department of Neurology of Pomeranian Medical University in Szczecin, Szczecin, Poland •Other: Symptomatic treatment of ALS 74 Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Suspended No Results Available •Amyotrophic Lateral Sclerosis •Biological: autologous bone marrow- •TCA Cellular Therapy, Covington, Louisiana, United States Sclerosis derived stem cells 75 Therapeutic Imaging Biomarkers for Amyotrophic Lateral Terminated No Results Available •Amyotrophic Lateral Sclerosis •Other: MRI •University of Michigan Hospital, Ann Arbor, Michigan, United Sclerosis States 76 A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis Completed Has Results •Amyotrophic Lateral Sclerosis •Drug: Inosine •Massachusetts General Hospital, Boston, Massachusetts, (ALS) United States 77 Safety and Tolerability of Antiretroviral (Triumeq) in Patients Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Triumeq •Macquarie Neurology, North Ryde, New South Wales, Australia With Amyotrophic Lateral Sclerosis (ALS). •Westmead Hospital, Parramatta, New South Wales, Australia •Brain and Mind Centre, Sydney, New South Wales, Australia •Calvary Health Care Bethlehem, Caulfield South, Victoria, Australia 78 Prognostic Value of a Diaphragmatic Endurance Test in Recruiting No Results Available •ALS (Amyotrophic Lateral Sclerosis) •Other: Diaphragmatic endurance test •CHU de SAINT-ETIENNE, Saint-etienne, France Patients With Amyotrophic Lateral Sclerosis

- Page 8 of 12 - Title Status Study Results Conditions Interventions Locations 79 Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Drug: Cistanche Total Glycosides •Dongsheng Fan, MD; Liping Wang,MD, Beijing, Beijing, China A Randomized Control Trial (RCT) Study Assessing Clinical Response 80 Food Supplement for the Treatment of Patients With Suspended No Results Available •Amyotrophic Lateral Sclerosis •Drug: Spirit1 •Hacarmel Hospital, Haifa, Israel Amyotrophic Lateral Sclerosis 81 Nightime NIV Initiation in Amyotrophic Lateral Sclerosis in an Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Nightime NIV initiation Outpatient Setting 82 Autologous Mesenchymal Bone Marrow Stromal Cells Completed No Results Available •Amyotrophic Lateral Sclerosis •Biological: MSC_NTF cells transplantation •Hadassah Medical Organization, Jerusalem, Israel Secreting Neurotrophic Factors (MSC-NTF), in Patients With by multiple intramuscular injections at Amyotrophic Lateral Sclerosis (ALS) 24 separate sites, in addition to a single intrathechal injection into the CSF 83 Growth Hormone in Amyotrophic Lateral Sclerosis Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Growth Hormone (Somatropin) •Diparimento di Scienze Neurologiche, Naples, Italy •Drug: Placebo •Istituto Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy 84 Efficacy and Safety of Plasma Exchange With Albumin in Completed Has Results •Amyotrophic Lateral Sclerosis •Biological: Albumin •Hospital Universitari Bellvitge, Hospitalet de Llobregat, Patients With Amyotrophic Lateral Sclerosis Barcelona, Spain 85 Mexiletine in Sporadic Amyotrophic Lateral Sclerosis Completed Has Results •Sporadic Amyotrophic Lateral Sclerosis •Drug: Mexiletine •Barrow Neurological Institute, Phoenix, Arizona, United States •Drug: Placebo •University of California, Irvine, Orange, California, United States •Augusta University, Augusta, Georgia, United States •Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States •University of Michigan, Ann Arbor, Michigan, United States •Columbia Universtiy Medical Center, New York, New York, United States •Pennsylvania State Hershey Medical Center, Hershey, Pennsylvania, United States •University of Pittsburgh, Pittsburgh, Pennsylvania, United States •Medical University of South Carolina, Charleston, South Carolina, United States •University of Washington, Seattle, Washington, United States 86 Effect of Motor Rehabilitation Treatment on Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Standard motor rehabilitation •Department of Neuroscience, S. Anna Hospital, Ferrara, Italy Lateral Sclerosis (ALS) treatment •Department of Neuroscience, S.Agostino-Estense Hospital, •Procedure: Intensive motor rehabilitation Modena, Italy treatment •Department of Neuroscience, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy 87 Mesenchymal Stem Cell Injection in Amyotrophic Lateral Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Biological: mesenchymal stem cell •Neurosciences Research Center, Isfahan, Iran, Islamic Republic Sclerosis of 88 Stem Cell Therapy for Amyotrophic Lateral Sclerosis Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Biological: Stem cell •Neurogen brain and spine institute, Mumbai, Maharashtra, India

- Page 9 of 12 - Title Status Study Results Conditions Interventions Locations 89 A Study of GDC-0134 to Determine Initial Safety, Tolerability, Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: GDC-0134 •Forbes Norris Mda/als Ctr; Research Center, San Francisco, and Pharmacokinetic Parameters in Participants With California, United States •Drug: Placebo Amyotrophic Lateral Sclerosis •Mayo Clinic Hospital - Florida, Jacksonville, Florida, United •Drug: Rabeprazole States •Drug: Midazolam •University of Miami Miller School of Medicine, Miami, Florida, •Drug: Caffeine United States •The Emory ALS Clinic, Atlanta, Georgia, United States •Johns Hopkins University School of Medicine, Baltimore, Maryland, United States •Massachusetts General Hospital, Boston, Massachusetts, United States •Wake Research Associates, Raleigh, North Carolina, United States •New Orleans Center for Clinical Research, Knoxville, Tennessee, United States •MUCH - Montreal Neurological Institute & Hospital, Montreal, Quebec, Canada •UMC Utrecht, Utrecht, Netherlands 90 Imaging and BioFluid Biomarkers in Amyotrophic Lateral Completed No Results Available •Amyotrophic Lateral Sclerosis (ALS) •Drug: [18F] GE-180 •Massachusetts General Hospital, Boston, Massachusetts, Sclerosis United States •Houston Methodist Hospital, Houston, Texas, United States 91 Safety and Efficacy Study of NP001 in Patients With Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: NP001 •St. Joseph's Hospital and Medical Center - Barrow Neurology Amyotrophic Lateral Sclerosis (ALS) and Systemic Clinics, Phoenix, Arizona, United States •Drug: Placebo Inflammation •Mayo Clinic Arizona, Scottsdale, Arizona, United States •Cedars-Sinai Medical Center, Los Angeles, California, United States •University of California, Irvine, Department of Neurology, Orange, California, United States •Forbes Norris MDA/ALS Research Center, CPMC, San Francisco, California, United States •, Jacksonville, Florida, United States •University of Miami Miller School of Medicine, Miami, Florida, United States •Emory University, Department of Neurology, Atlanta, Georgia, United States •University of Kansas Medical Center, Kansas City, Kansas, United States •University of Kentucky, Albert B. Chandler Medical Center, Lexington, Kentucky, United States •and 12 more 92 Clinical Trial on The Use of Autologous Bone Marrow Stem Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Laminectomy and bone marrow •Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Cells in Amyotrophic Lateral Sclerosis (Extension CMN/ELA) stem cells transplantation Spain •Procedure: Intrathecal infusion of autologous bone marrow stem cells •Procedure: Intrathecal infusion of placebo (saline solution).

- Page 10 of 12 - Title Status Study Results Conditions Interventions Locations 93 An Efficacy, Safety, Tolerability, Pharmacokinetics and Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: BIIB067 •Barrow Neurological Institute, Phoenix, Arizona, United States Pharmacodynamics Study of BIIB067 in Adults With Inherited •Other: Placebo •University of California San Diego Medical Center, La Jolla, Amyotrophic Lateral Sclerosis (ALS) California, United States •California Pacific Medical Center, San Francisco, California, United States •Mayo Clinic in Florida, Jacksonville, Florida, United States •University of Miami School of Medicine, Miami, Florida, United States •Bioclinica Research, Orlando, Florida, United States •Emory University Hospital, Atlanta, Georgia, United States •Johns Hopkins University, Baltimore, Maryland, United States •Massachusetts General Hospital, Boston, Massachusetts, United States •Henry Ford Hospital, Detroit, Michigan, United States •and 21 more 94 Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Placebo •CHRU de Montpellier - Hôpital Gui de Chauliac, Montpellier, II Study of Safety and Activity of Low Dose Interleukin-2 France •Drug: 1.0 MIU IL-2 per day •Drug: 2.0 MIU IL-2 per day 95 Gilenya in Amyotrophic Lateral Sclerosis (ALS) Completed Has Results •Amyotrophic Lateral Sclerosis •Drug: Gilenya •University of California, Irvine, Orange, California, United States •Other: Placebo •Georgia Regents University, Augusta, Georgia, United States •Massachusetts General Hospital, Boston, Massachusetts, United States •Methodist Neurological Institute, Houston, Texas, United States 96 Therapeutic Nanocatalysis to Slow Disease Progression of Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: CNM-Au8 •University of Sydney Brain and Mind Centre, Sydney, New Amyotrophic Lateral Sclerosis (ALS) South Wales, Australia •Drug: Placebo •Westmead Hospital, Sydney, New South Wales, Australia 97 PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •University of Miami, Miami, Florida, United States 98 Safety and Efficacy Study of Creatine and Tamoxifen in Completed Has Results •Amyotrophic Lateral Sclerosis •Drug: creatine •University of Kansas Medical Center, Kansas City, Kansas, Volunteers With Amyotrophic Lateral Sclerosis (ALS) United States •Drug: tamoxifen •Massachusetts General Hospital, Boston, Massachusetts, United States •University of Massachusetts Medical Center, Worcester, Massachusetts, United States •Washington University at St. Louis, St. Louis, Missouri, United States •SUNY Upstate Medical University, Syracuse, New York, United States •Carolinas Medical Center, Charlotte, North Carolina, United States •Pennsylvania State University, Hershey Medical Center, Hershey, Pennsylvania, United States •University of Washington Medical Center, Seattle, Washington, United States •Medical College of Wisconsin, Milwaukee, Wisconsin, United States 99 Cervical Spinal Cord Metabolism and Microstructure in Terminated No Results Available •Amyotrophic Lateral Sclerosis •Other: MRI •University of Michigan Hospital, Ann Arbor, Michigan, United Amyotrophic Lateral Sclerosis(ALS) States •Other: Clinical Exam

- Page 11 of 12 - Title Status Study Results Conditions Interventions Locations 100 G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: Granulocyte Colony Stimulating •Dongsheng Fan, Beijing, Beijing, China Study Assessing Clinical Response Factor •Drug: NS

593 additional studies not shown

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