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Update on ALS Clinical Trials

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Update on ALS Clinical Trials ClinicalTrials.gov Search Results 06/24/2020 Title Status Study Results Conditions Interventions Locations 1 A Study to Evaluate AP-101 in Familial and Sporadic Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: AP-101 •Kaye Edmonton Clinic, University of Alberta, Edmonton, Alberta, Amyotrophic Lateral Sclerosis (ALS) Canada •London Health Sciences Centre, University Hospital, London, Ontario, Canada •Sunnybrook Health Sciences Centre, Toronto, Toronto, Ontario, Canada •Montreal Neurological Institute & Hospital, Montréal, Quebec, Canada 2 Trial of Amivita in Amyotrophic Lateral Sclerosis Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Drug: Amivita •Wujing People's Hospital, Changzhou, Jiangsu, China 3 Amyotrophic Lateral Sclerosis: a New Paradigm Completed No Results Available •Amyotrophic Lateral Sclerosis •Genetic: ALS patients genetic •Centro Hospitalar Tras-os-Montes e Alto Douro, Vila Real, characterization Portugal •Other: ALS patients epidemiological caracterization 4 Safety and Tolerability of High Dose Biotin in Patients With Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Biotin •American univeristy of Beirut medical center, Beirut, Lebanon Amyotrophic Lateral Sclerosis •Drug: Placebo Oral Tablet 5 Rehabilitative Trial With tDCS in Amyotrophic Lateral Completed Has Results •Amyotrophic Lateral Sclerosis •Device: Anodal bilateral motor cortex and •AO Spedali Civili, Brescia, BS, Italy Sclerosis cathodal spinal tDCS •Device: Sham bilateral motor cortex and sham spinal tDCS 6 A Registered Cohort Study on Amyotrophic Lateral Sclerosis Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Department of Neurology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China 7 Trial of Safety, Tolerability and Efficacy of Trametinib Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Trametinib (0.5 mg) •Asan Medical Center, Seoul, Korea, Republic of (SNR1611) in Patients With Amyotrophic Lateral Sclerosis •Drug: Trametinib (1 mg) •Korea University Anam Hospital, Seoul, Korea, Republic of (ALS) •Drug: Trametinib (2 mg) •Samsung Medical Center, Seoul, Korea, Republic of •Drug: Riluzole (100 mg) •Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of 8 Exploratory Study of Biotelemetry in Amyotrophic Lateral Completed Has Results •Amyotrophic Lateral Sclerosis •Device: Faros Sensor (FS) and LifeInsight •GSK Investigational Site, London, United Kingdom Sclerosis Hub •GSK Investigational Site, Oxford, United Kingdom •Device: Fast Fix electrode patch •Procedure: Quantitative Measure of Speech (Core Phase Only) 9 The National Amyotrophic Lateral Sclerosis Registry Recruiting No Results Available •Amyotrophic Lateral Sclerosis •CDC, Atlanta, Georgia, United States 10 Compassionate Treatment : An Exploratory Clinical Trial to Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Autologous Adipose-Tissue •China Medical University Beigang Hospital, Beigang, Yunlin, Assess Treatment of Amyotrophic Lateral Sclerosis Derived Stem Cells Taiwan 11 Study of Cognitive and Emotional Disorders in Amyotrophic Unknown status No Results Available •Amyotrophic Lateral Sclerosis •Other: MRI + 18FDG-PET + •University Hospital Center, Caen, France Lateral Sclerosis neuropsychological assessments ; 18FDG •University Hospital Center, Rouen, France performed especially for the research 12 Repetitive Transcranial Magnetic Stimulation as Therapy for Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Device: rTMS •Jagiellonian University Medical College, Department of Apathy in Amyotrophic Lateral Sclerosis Neurology, Kraków, Poland 13 Transcranial Static Magnetic Field Stimulation (tSMS) in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Device: tSMS •Department of Neurology and Laboratory of Neuroscience, Amyotrophic Lateral Sclerosis (ALS). Istituto Auxologico Italiano, IRCCS, Milan, Italy •Device: sham tSMS •Neurology Unit, Campus Biomedico University, Rome, Italy - Page 1 of 12 - Title Status Study Results Conditions Interventions Locations 14 Colchicine for Amyotrophic Lateral Sclerosis Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Colchicine 1 MG Oral Tablet •Centro Sla, University of Bari, Bari, Italy •Drug: Placebo Oral Tablet •Centro Sla, Istituto Auxologico Italiano, University of Milano, Milano, Milano, Italy •Irccs Carlo Besta, Milano, Italy •Irccs St. Raffaele Institute of Milano, Milano, Italy •Centro Sla, Ospedale Civile S. Agostino Estense, A.O.U. Modena, Modena, Italy •Università della Campania Gianluigi Vanvitelli, Napoli, Italy •Centro Sla, Universita' Di Padova, Padova, Italy •Als Centre, "C. Mondino" National Neurological Institute, University of Pavia, Pavia, Italy •, Neuromuscular Omnicentre Centre, Rome, Catholic University, Rome, Roma, Italy •Centro Sla, Universita' Di Torino, Torino, Italy 15 Epidemiology and Genetics of the Amyotrophic Lateral Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Dietary Supplement: Blood sample and •Hospital University Center of Pointe-à-Pitre, Pointe-à-Pitre, Sclerosis in the French West Indies environmental survey Guadeloupe •Hospital University Center of Martinique, Fort-de-France, Martinique 16 In-situ Cytokines Expression in the CNS in Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Other: in-situ cytokine expression •CHU Brugmann, Brussels, Belgium Lateral Sclerosis (ALS) 17 Virtual Task in Amyotrophic Lateral Sclerosis Completed No Results Available •Amyotrophic Lateral Sclerosis •Device: Acquisition on TouchScreen •Escola de Artes,Ciencias e Humanidades da Universidade d Sao Paulo, Sao Paulo, Brazil •Device: Acquisition on Kinect •Device: Acquisition on LeapMotion •Device: Acquisition on TouchScreen Control Group •Device: Acquisition on Kinect Control Group •Device: Acquisition on LeapMotion Control Group 18 Muscular Biomarkers in Amyotrophic Lateral Sclerosis Active, not recruiting No Results Available •Amyotrophic Lateral Sclerosis •Other: Samples •Service de chirurgie orthopédique et traumatologique, CHRU de TOURS, Tours, France •Service de Neurologie, CHRU de TOURS, Tours, France 19 HERV-K Suppression Using Antiretroviral Therapy in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Darunavir •National Institutes of Health Clinical Center, 9000 Rockville Volunteers With Amyotrophic Lateral Sclerosis (ALS) Pike, Bethesda, Maryland, United States •Drug: Ritonavir •Drug: dolutegravir •Drug: Tenofovir alafenamide (TAF) 20 Repetitive Transcranial Magnetic Stimulation as Therapy for Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Device: active repetitive transcranial •Jagiellonian University Medical College, Department of Depression in Amyotrophic Lateral Sclerosis magnetic stimulation Neurology, Kraków, Poland •Device: sham repetitive transcranial magnetic stimulation - Page 2 of 12 - Title Status Study Results Conditions Interventions Locations 21 A Study to Evaluate Efficacy, Safety and Tolerability of Completed No Results Available •Amyotrophic Lateral Sclerosis •Drug: CK-2127107 •St. Joseph's Hospital and Medical Center - Barrow Neurological CK-2127107 in Patients With Amyotrophic Lateral Sclerosis Clinics, Phoenix, Arizona, United States •Drug: Placebo (ALS) •Cedars-Sinai Medical Center, Los Angeles, California, United States •University of California Irvine, Orange, California, United States •Forbes Norris MDA/ALS Research Center, San Francisco, California, United States •Stanford Hospital and Clinics, Stanford, California, United States •University of Colorado Hospital Anschutz Outpatient Pavilion, Aurora, Colorado, United States •Hospital for Special Care, New Britain, Connecticut, United States •George Washington University Medical Faculty Associates, Washington, District of Columbia, United States •University of Florida, Gainesville, Florida, United States •Mayo Clinic, Jacksonville, Florida, United States •and 54 more 22 Bioenergetics and Protein Metabolism in Sporadic Unknown status No Results Available •Sporadic Amyotrophic Lateral Sclerosis •Other: Skin Biopsy Amyotrophic Lateral Sclerosis 23 Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral Withdrawn No Results Available •Amyotrophic Lateral Sclerosis •Biological: Stem Cell •Neurogen brain and spine institute, Navi Mumbai, Maharashtra, Sclerosis India 24 Influence of the Vitamin D Blood Levels on the Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Procedure: Blood test •UH Montpellier, Montpellier, France Lateral Sclerosis Phenotype 25 Amyotrophic Lateral Sclerosis Web Based Patient Care Completed No Results Available •Amyotrophic Lateral Sclerosis •Behavioral: ALS Registry •Forbes Norris MDA/ALS Center, San Francisco, California, Database: ALSConnection.Org United States 26 Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Recruiting No Results Available •Amyotrophic Lateral Sclerosis •Peking University Third Hospital, Beijing, Beijing, China Mainland China 27 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Not yet recruiting No Results Available •Amyotrophic Lateral Sclerosis •Drug: Gold Nanocrystals •UT Southwestern, Dallas, Texas, United States Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) 28 Quantitative Neuromuscular Ultrasonography in Amyotrophic Completed No Results Available •Amyotrophic Lateral Sclerosis •Universidad Católica San Antonio de
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