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Polyphenols in Cancer Prevention: New Insights (Review)
INTERNATIONAL JOURNAL OF FUNCTIONAL NUTRITION 1: 9, 2020 Polyphenols in cancer prevention: New insights (Review) GIUSI BRIGUGLIO1, CHIARA COSTA2, MANUELA POLLICINO1, FEDERICA GIAMBÒ1, STEFANIA CATANIA1 and CONCETTINA FENGA1 1Department of Biomedical and Dental Sciences and Morpho‑functional Imaging, Occupational Medicine Section, and 2Department of Clinical and Experimental Medicine, University of Messina, I‑98125 Messina, Italy Received July 30, 2020; Accepted September 21, 2020 DOI:10.3892/ijfn.2020.9 Abstract. A huge volume of literature data suggests that a diet Contents rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific 1. Introduction cancers. Resveratrol, epigallocatechin gallate and curcumin 2. Literature search are among the most extensively studied polyphenols: The 3. Classification of polyphenols majority of the effects attributed to these compounds are 4. Prostate cancer linked to their antioxidant and anti‑inflammatory properties. 5. Colon cancer The multiple mechanisms involved include the modulation 6. Breast cancer of molecular events and signaling pathways associated with 7. Lung cancer cell survival, proliferation, differentiation, migration, angio‑ 8. Bladder cancer genesis, hormonal activities, detoxification enzymes and 9. Skin cancer immune responses. Notwithstanding their promising role in 10. Pancreatic cancer cancer prevention and treatment, polyphenols often have a 11. Leukemia poor bioavailability when administered as pure active prin‑ -
Valorisation of Olea Europaea L. Olive Leaves Through the Evaluation of Their Extracts: Antioxidant and Antimicrobial Activity
foods Article Valorisation of Olea europaea L. Olive Leaves through the Evaluation of Their Extracts: Antioxidant and Antimicrobial Activity Mónica Sánchez-Gutiérrez 1,2,* , Isabel Bascón-Villegas 1,2 , Alejandro Rodríguez 2 , Fernando Pérez-Rodríguez 1, África Fernández-Prior 3 , Antonio Rosal 4 and Elena Carrasco 1 1 Food Science and Technology Department, Universidad de Córdoba, Darwin Building, 14014 Córdoba, Spain; [email protected] (I.B.-V.); [email protected] (F.P.-R.); [email protected] (E.C.) 2 BioPrEn Group, Chemical Engineering Department, Universidad de Córdoba, Marie-Curie Building, 14014 Córdoba, Spain; [email protected] 3 Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), Campus Universitario Pablo de Olavide, Edificio 46, Ctra. de Utrera, km. 1, 41013 Seville, Spain; [email protected] 4 Molecular Biology and Biochemical Engineering Department, Campus Universitario Pablo de Olavide, Edificio 46, Ctra. de Utrera, km. 1, 41013 Seville, Spain; [email protected] * Correspondence: [email protected] Abstract: Olea europaea L. leaves constitute a source of bioactive compounds with recognized benefits for both human health and technological purposes. In the present work, different extracts from olive leaves were obtained by the application of two extraction methods, Soxhlet and microwave-assisted extraction (MAE), and six solvents (distilled water, ethanolic and glycerol mixtures solvents). MAE Citation: Sánchez-Gutiérrez, M.; was applied under 40, 60 and 80 ◦C for 3, 6.5 and 10 min. The effect of the extraction method, solvent Bascón-Villegas, I.; Rodríguez, A.; and treatment factors (the latter in MAE) on the total phenol content (TPC), the antioxidant activity Pérez-Rodríguez, F.; Fernández-Prior, Á.; Rosal, A.; Carrasco, E. -
Thyroid-Modulating Activities of Olive and Its Polyphenols: a Systematic Review
nutrients Review Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review Kok-Lun Pang 1,† , Johanna Nathania Lumintang 2,† and Kok-Yong Chin 1,* 1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia; [email protected] 2 Faculty of Applied Sciences, UCSI University Kuala Lumpur Campus, Jalan Menara Gading, Taman Connaught, Cheras 56000, Kuala Lumpur, Malaysia; [email protected] * Correspondence: [email protected]; Tel.: +60-3-91459573 † These authors contributed equally to this work. Abstract: Olive oil, which is commonly used in the Mediterranean diet, is known for its health benefits related to the reduction of the risks of cancer, coronary heart disease, hypertension, and neurodegenerative disease. These unique properties are attributed to the phytochemicals with potent antioxidant activities in olive oil. Olive leaf also harbours similar bioactive compounds. Several studies have reported the effects of olive phenolics, olive oil, and leaf extract in the modulation of thyroid activities. A systematic review of the literature was conducted to identify relevant studies on the effects of olive derivatives on thyroid function. A comprehensive search was conducted in October 2020 using the PubMed, Scopus, and Web of Science databases. Cellular, animal, and human studies reporting the effects of olive derivatives, including olive phenolics, olive oil, and leaf extracts on thyroid function were considered. The literature search found 445 articles on this topic, but only nine articles were included based on the inclusion and exclusion criteria. All included articles were animal studies involving the administration of olive oil, olive leaf extract, or olive pomace residues orally. -
Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus Angu
Article Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study Rocío García-Villalba 1, Francisco A. Tomás-Barberán 1, Pascale Fança-Berthon 2, Marc Roller 2, Pilar Zafrilla 3, Nicolas Issaly 4 and María-Teresa García-Conesa 1,* Received: 9 November 2015 ; Accepted: 4 December 2015 ; Published: 11 December 2015 Academic Editor: Emilie Combet 1 Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura (CEBAS)–Consejo Superior de Investigaciones Científicas (CSIC), P. O. Box 164, Campus de Espinardo, Murcia 30100, Spain; [email protected] (R.G.-V.); [email protected] (F.A.T.-B.) 2 Naturex SA, Site d’AgroParc, BP 1218, 84911 Avignon Cedex 9, France; [email protected] (P.F.-B.); [email protected] (M.R.) 3 Department of Food Technology and Nutrition, Catholic University of San Antonio, Campus de los Jerónimos, N˝ 135, Guadalupe, Murcia 30107, Spain; [email protected] 4 Naturex Spain SL, Autovia A3, Salida343, Camino de Torrent s/n, Quart de Poblet, Valencia 46930, Spain; [email protected] * Correspondence: [email protected]; Tel.: +34-968-396-276; Fax: +34-968-396-102 Abstract: The bark, seeds, fruits and leaves of the genus Fraxinus (Oleaceae) which contain a wide range of phytochemicals, mostly secoiridoid glucosides, have been widely used in folk medicine against a number of ailments, yet little is known about the metabolism and uptake of the major Fraxinus components. -
Oleuropein Or Rutin Consumption Decreases the Spontaneous Development of Osteoarthritis in the Hartley Guinea Pig
Osteoarthritis and Cartilage 23 (2015) 94e102 Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig M.-N. Horcajada y a, C. Sanchez z a, F. Membrez Scalfo y, P. Drion x, F. Comblain z, * S. Taralla k, A.-F. Donneau ¶, E.A. Offord y, Y. Henrotin z # y Nestle Research Center, Nutrition and Health Research, Vers-Chez-les-Blanc, Lausanne 26 1000, Switzerland z Bone and Cartilage Research Unit, Arthropole,^ University of Liege, Institute of Pathology, CHU Sart-Tilman, 4000 Liege, Belgium x GIGA CHU Animal Facility, University of Liege, 4000 Liege, Belgium k Artialis SA, 4000 Liege Belgium ¶ Public Health Department, University of Liege, 4000 Liege, Belgium # Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-famenne, Belgium article info summary Article history: Objective: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, Received 10 February 2014 on joint ageing and osteoarthritis (OA) development. Accepted 28 August 2014 Design: Sixty 4-week-old DunkineHartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet Keywords: enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers Osteoarthritis of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation prostaglandin E2 (PGE2) were Phytonutrients quantified in the serum. Histological assessments of knee cartilage and synovial membrane were per- Oleuropein fi Rutin formed at week 4 ( ve young reference guinea pigs) and week 35. -
Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds Na-Kyoung Lee1 and Hyun-Dong Paik1,2*
J. Microbiol. Biotechnol. (2017), 27(5), 869–877 https://doi.org/10.4014/jmb.1612.12005 Research Article Review jmb Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds Na-Kyoung Lee1 and Hyun-Dong Paik1,2* 1Department of Food Science and Biotechnology of Animal Resources, 2Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Republic of Korea Received: December 14, 2016 Revised: February 24, 2017 Lactic acid bacteria (LAB) are used as fermentation starters in vegetable and dairy products Accepted: March 15, 2017 and influence the pH and flavors of foods. For many centuries, LAB have been used to manufacture fermented foods; therefore, they are generally regarded as safe. LAB produce various substances, such as lactic acid, β-glucosidase, and β-galactosidase, making them First published online useful as fermentation starters. Existing functional substances have been assessed as March 15, 2017 fermentation substrates for better component bioavailability or other functions. Representative *Corresponding author materials that were bioconverted using LAB have been reported and include minor Phone: +82-2-2049-6011; ginsenosides, γ-aminobutyric acid, equol, aglycones, bioactive isoflavones, genistein, and Fax: +82-2-455-3082; daidzein, among others. Fermentation mainly involves polyphenol and polysaccharide E-mail: [email protected] substrates and is conducted using bacterial strains such as Streptococcus thermophilus, Lactobacillus plantarum, and Bifidobacterium sp. In this review, we summarize recent studies of pISSN 1017-7825, eISSN 1738-8872 bioconversion using LAB and discuss future directions for this field. Copyright© 2017 by The Korean Society for Microbiology Keywords: Lactic acid bacteria, fermentation, bioconversion, phenolic compound, β-glucosidase and Biotechnology Introduction be selected for their potential nutritional benefits. -
The Biological Activities of Oleocanthal from a Molecular Perspective
nutrients Review The Biological Activities of Oleocanthal from a Molecular Perspective Kok-Lun Pang 1 and Kok-Yong Chin 2,* 1 Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; [email protected] 2 Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia * Correspondence: [email protected]; Tel.: +60-16-708-2900 Received: 10 April 2018; Accepted: 3 May 2018; Published: 6 May 2018 Abstract: Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since the pathogenesis of many chronic diseases involves inflammatory and oxidative components, oleocanthal is a promising agent to prevent these conditions. This review aimed to summarise the current beneficial health effects of oleocanthal and the molecular basis of its biological actions. The anti-inflammatory, antioxidative, antimicrobial, anticancer and neuroprotective activities of oleocanthal have been examined by previous studies. Of these, studies on the anticancer effects have been the most extensive. Oleocanthal was reported to suppress melanoma, breast, liver, and colon cancer cells. Neurological studies focused on the effects of oleocanthal against Alzheimer’s disease. Oleocanthal improved clearance of the amyloid beta protein from neurons and reduced the inflammation of astrocytes. Despite the positive results, validation of the biological effects of oleocanthal in animal disease models is limited and should be emphasized in the future. As a conclusion, oleocanthal may act together with other bioactive compounds in olive oil to achieve its therapeutic potential. The use of oleocanthal alone as a single therapeutic measure awaits validation from future studies. -
Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis
molecules Review Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis Dounia Elfadil 1,2, Abderrahman Lamaoui 2 , Flavio Della Pelle 1 , Aziz Amine 2,* and Dario Compagnone 1,* 1 Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy; [email protected] (D.E.); [email protected] (F.D.P.) 2 Laboratory of Process Engineering and Environment, Faculty of Sciences and Techniques, Hassan II University of Casablanca, Mohammedia 28810, Morocco; [email protected] * Correspondence: [email protected] (A.A.); [email protected] (D.C.) Abstract: Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP- Citation: Elfadil, D.; Lamaoui, A.; based electrochemical sensing are discussed as well as the relevant applications of MIPs used in Della Pelle, F.; Amine, A.; sample preparation and then coupled to electrochemical analysis. -
Analytical Reference Standards
Cerilliant Quality ISO GUIDE 34 ISO/IEC 17025 ISO 90 01:2 00 8 GM P/ GL P Analytical Reference Standards 2 011 Analytical Reference Standards 20 811 PALOMA DRIVE, SUITE A, ROUND ROCK, TEXAS 78665, USA 11 PHONE 800/848-7837 | 512/238-9974 | FAX 800/654-1458 | 512/238-9129 | www.cerilliant.com company overview about cerilliant Cerilliant is an ISO Guide 34 and ISO 17025 accredited company dedicated to producing and providing high quality Certified Reference Standards and Certified Spiking SolutionsTM. We serve a diverse group of customers including private and public laboratories, research institutes, instrument manufacturers and pharmaceutical concerns – organizations that require materials of the highest quality, whether they’re conducing clinical or forensic testing, environmental analysis, pharmaceutical research, or developing new testing equipment. But we do more than just conduct science on their behalf. We make science smarter. Our team of experts includes numerous PhDs and advance-degreed specialists in science, manufacturing, and quality control, all of whom have a passion for the work they do, thrive in our collaborative atmosphere which values innovative thinking, and approach each day committed to delivering products and service second to none. At Cerilliant, we believe good chemistry is more than just a process in the lab. It’s also about creating partnerships that anticipate the needs of our clients and provide the catalyst for their success. to place an order or for customer service WEBSITE: www.cerilliant.com E-MAIL: [email protected] PHONE (8 A.M.–5 P.M. CT): 800/848-7837 | 512/238-9974 FAX: 800/654-1458 | 512/238-9129 ADDRESS: 811 PALOMA DRIVE, SUITE A ROUND ROCK, TEXAS 78665, USA © 2010 Cerilliant Corporation. -
Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems ELENI BAGLI 1,2 , ANNA GOUSSIA 3, MARILITA M
in vivo 30 : 535-548 (2016) Review Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems ELENI BAGLI 1,2 , ANNA GOUSSIA 3, MARILITA M. MOSCHOS 4, NIKI AGNANTIS 3 and GEORGIOS KITSOS 2 1Institute of Molecular Biology and Biotechnology - FORTH, Division of Biomedical Research, Ioannina, Greece; 2Department of Ophthalmology, University of Ioannina, Ioannina, Greece; 3Department of Pathology, University of Ioannina, Ioannina, Greece; 4Department of Ophthalmology, University of Athens, Athens, Greece Abstract. Neurodegeneration characterizes pathologic pathological events, including oxidative stress, mitochondrial conditions, ranging from Alzheimer’s disease to glaucoma, dysfunction, inflammation and protein aggregation (2, 3). with devastating social and economic effects. It is a The increasing knowledge of the cellular and molecular complex process implicating a series of molecular and events underlying the degenerative process has greatly cellular events, such as oxidative stress, mitochondrial stimulated research for identifying compounds capable of dysfunction, protein misfolding, excitotoxicity and stopping or, at least, slowing the progress of neural inflammation. Natural compounds, because of their broad deterioration. spectrum of pharmacological and biological activities, Natural compounds are complex chemical multiple-target could be possible candidates for the management of such molecules found mainly in plants and microorganisms (4). multifactorial morbidities. However, their therapeutic These agents -
Oleuropein Alleviates Gestational Diabetes Mellitus by Activating AMPK Signaling
ID: 20-0466 10 1 Z Zhang, H Zhao et al. Oleuropein activates AMPK 10:1 45–53 signaling RESEARCH Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling Zhiwei Zhang*, Hui Zhao* and Aixia Wang Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China Correspondence should be addressed to A Wang: [email protected] *(Z Zhang and H Zhao contributed equally to this work) Abstract Background: Gestational diabetes mellitus (GDM) has a high incidence rate among Key Words pregnant women. The objective of the study was to assess the effect of plant-derived f oleuropein oleuropein in attenuating inflammatory and oxidative stress of GDM. f gestational diabetes Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/ mellitus day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To f oxidative stress evaluate the effect of oleuropein in reducing oxidative stress, ELISA was used to measure f inflammation the hepatic oxidative stress markers. The inflammation levels of GDM mice were f AMPK signaling evaluated by measuring serum levels of IL-6 and TNF-α by ELISA and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. -
Quantitation of Oleuropein and Related Phenolics in Cured Spanish-Style Green, California- Style Black Ripe, and Greek-Style Natural Fermentation Olives
UC Davis UC Davis Previously Published Works Title Quantitation of Oleuropein and Related Phenolics in Cured Spanish-Style Green, California- Style Black Ripe, and Greek-Style Natural Fermentation Olives. Permalink https://escholarship.org/uc/item/3t34332d Journal Journal of agricultural and food chemistry, 66(9) ISSN 0021-8561 Authors Johnson, Rebecca Melliou, Eleni Zweigenbaum, Jerry et al. Publication Date 2018-03-01 DOI 10.1021/acs.jafc.7b06025 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Article Cite This: J. Agric. Food Chem. 2018, 66, 2121−2128 pubs.acs.org/JAFC Quantitation of Oleuropein and Related Phenolics in Cured Spanish-Style Green, California-Style Black Ripe, and Greek-Style Natural Fermentation Olives † ‡ § Rebecca Johnson, Eleni Melliou, Jerry Zweigenbaum, and Alyson E. Mitchell* † Department of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, California 95616, United States ‡ Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece § Agilent Technologies, 2850 Centerville Road, Wilmington, Delaware 19808, United States *S Supporting Information ABSTRACT: Oleuropein, ligstroside, and related hydrolysis products are key contributors to olive bitterness, and several of these phenolics are implicated in the prevention of lifestyle age-related diseases. While table olive processing methods are designed to reduce oleuropein, the impact of processing on ligstroside and related hydrolysis products (e.g., oleacein, oleocanthal, hydroxytyrosol glucoside, ligstroside aglycone, and oleuropein aglycone) is relatively unknown. Herein, levels of these com- pounds were measured in Spanish-style green (SP), Californian-style black ripe (CA), and Greek-style natural fermentation (GK) olives using rapid ultrahigh-performance liquid chromatography (UHPLC) tandem mass spectrometry (MS/MS).