Answers to Frequently Asked Questions About HIV/AIDS. ?
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STI Screening Timetable
Patient Education Information from University Health Center’s STI Screening Clinic Page 1 of 1 STI Screening Timetable How long until STI (sexually transmitted infection) screening tests turn positive? How long until STI symptoms might show up? The time between infection and a positive test, or between infection and symptoms, is variable and depends on many factors, including the behavior of the infectious agent, how and where the body is infected, and the state of a person’s immune system and personal health. Many STIs don’t have any symptoms. The incubation period times listed in the chart below are averages only. If you have further questions or concerns, you can schedule an appointment with a clinician at 541-346-2770. STI screening test Window period (time from exposure until Incubation period (time between exposure and screening test turns positive) when symptoms appear) Chlamydia (urine specimen or swab of 1 week most of the time Often no symptoms vagina, rectum, throat) 2 weeks catches almost all 1-3 weeks on average Gonorrhea (urine specimen on swab of 1 week most of the time Often no symptoms, especially vaginal vagina, rectum, throat) 2 weeks catches almost all infections usually within 2-8 days but can be up to 2 weeks Syphilis (blood test, RPR) 1 month catches most Often symptoms too mild to notice 3 months catches almost all 10-90 days average 21 days HIV (oral cheek swab) 1 month catches most Sometimes mild body aches and fever within 1-2 3 months catches almost all weeks then can be months to years HIV (blood test, antigen/antibody -
Hepatitis B and C Testing: Why? Who? How? a Guidance Paper on Testing in Community and Harm Reduction Settings 1 Colophon
Hepatitis B and C testing: why? who? how? A guidance paper on testing in community and harm reduction settings 1 Colophon This paper is a product of the Correlation Hepatitis C Initiative. You can access the paper at www.hepatitis-c-initiative.eu Author: Danny Morris Review: M. Harris, A. Kautz, A. Leicht, H. Lochtenberg, E. Schatz Copyright © 2016 Copyrights remains with the publisher Correlation Network PO Box 10887 1001 EW Amsterdam The Netherlands Phone.: +31 20 5317600 Fax.: +31 20 4203528 [email protected] Correlation Network is a part of the international activities of the Regenboog Groep. For more information: www.deregenboog.org The production of this paper has been supported by an unrestricted grant from Gilead Sciences Europe Ltd 2 Acknowledgements We want to thank the author Danny Morris and all who helped to draft this paper and the Regenboog Group, Abbvie and GILEAD for their financial support of the Hepatitis C Initiative. Eberhard Schatz Correlation Hepatitis C Initiative Amsterdam, December 2016 “The Hepatitis C Initiative aims to enhance the momentum of current HCV treatment opportunities and strives for universal access to essential HCV prevention and treatment for the most affected and under-served communities: people who use drugs.” 3 Content Chapter 1: Introduction 6 1.1 Hepatitis B and C infect one in fifty adults in the European Region 9 1.2 Higher rates of hepatitis among vulnerable groups 9 1.3 A public health approach to hepatitis 9 1.4 Harm reduction as prevention 10 1.5 Diagnosing hepatitis B and C 10 1.6 Awareness raising - key recommendations 11 1.7 Testing and diagnosis - key recommendations 13 Chapter 2: Who should be tested 14 2.1 Barriers to testing 16 2.2 Barriers to testing and treatment may include 16 2.3 Overcoming barriers to testing 17 2.4 Testing as standard practice 18 2.5 Pre and post-test discussion 18 2.6 Serological testing for viral hepatitis 20 4 Chapter 3: Screening technologies and development of non-invasive techniques 22 3.1 Venapuncture 23 3.2 Dried blood spot testing 24 3.3. -
Donor Testing and Risk: Current Prevalence, Incidence, and Residual Risk of Transfusion-Transmissible Agents in US Allogeneic Donations
Donor Testing and Risk: Current Prevalence, Incidence, and Residual Risk of Transfusion-Transmissible Agents in US Allogeneic Donations Shimian Zou, Susan L. Stramer, and Roger Y. Dodd Over the past 20 years, there has been a major increase virus (HIV) and human T-cell lymphotropic virus did in the safety of the blood supply, as demonstrated by not. The incidence (/100 000 person-years) of HIV and declining rates of posttransfusion infection and reduc- HCV among repeat donors showed apparent increases tions in estimated residual risk for such infections. from 1.55 and 1.89 in 2000 through 2001 to 2.16 Reliable estimates of residual risk have been possible and 2.98 in 2007 through 2008. These observed within the American Red Cross system because of the fluctuations confirm the need for continuous monitor- availability of a large amount of reliable and consistent ing and evaluation. The residual risk of HIV, HCV, and data on donations and infectious disease testing human T-cell lymphotropic virus among all allogeneic results. Among allogeneic blood donations, the pre- donations is currently below 1 per 1 million donations, valence rates of infection markers for hepatitis C virus and that of hepatitis B surface antigen is close to 1 per (HCV) and hepatitis B virus have decreased over time, 300 000 donations. although rates for markers of human immunodeficiency © 2012 Elsevier Inc. All rights reserved. HE BLOOD SUPPLY in the United States DEMOGRAPHY OF DONOR POPULATIONS T and many other countries has become safer In 2008, a total of 3 830 094 volunteer blood than ever, thanks to continuing improvements in donors successfully made 6 638 877 blood dona- donor selection and testing, along with broad tions to ARC Blood Services, with whole blood and improvements in public health. -
Sexually Transmitted Infection Prevention and Treatment
Sexually Transmitted Infection Prevention and Treatment Kevin L. Ard, MD, MPH Massachusetts General Hospital, The Fenway Institute Disclosures I have no financial disclosures. Doxycycline PEP is not FDA-approved. Learning objectives 1. Describe the epidemiology of syphilis, chlamydia, gonorrhea, and other STIs among LGBTQ populations 2. Summarize optimal screening strategies for STIs. 3. Outline approaches to STI control that can be integrated into primary care. 3 Caveats ▪ Many (most?) LGBTQ people do not face a high risk of STIs. ▪ Clinical care must be individualized, not based on group risk. ▪ Data about STIs among cisgender WSW are limited. ▪ Terms that describe identity and behavior are imperfect and change over time. The rate of chlamydia diagnosis is increasing. Sexually Transmitted Disease Surveillance 2017, CDC Proportion of STI clinic patients testing positive for chlamydia Sexually Transmitted Disease Surveillance 2017, CDC The rate of gonorrhea diagnosis is increasing. Sexually Transmitted Disease Surveillance 2017, CDC MSM face an increasing disparity in the rate of gonorrhea. Sexually Transmitted Disease Surveillance 2017, CDC Antimicrobial resistance in gonorrhea is increasing. Resistanc e Elevated MICs Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2017. Atlanta: U.S. Department of Health and Human Services; 2018. Neisseria gonorrhoeae — Percentage of Urethral Isolates with Elevated Azithromycin Minimum Inhibitory Concentrations (MICs) (≥2.0 µg/ml) and Elevated Ceftriaxone MICs (≥0.125 μg/ml) by Reported Sex of Sex Partners, Gonococcal Isolate Surveillance Project (GISP), 2011–2017 A. Azithromycin B. Ceftriaxone * No cases of elevated ceftriaxone MICs were reported among MSM in 2017. ACRONYMS: MSM = Gay, bisexual, and other men who have sex with men (collectively referred to as MSM); MSW = Men who have sex with women only. -
A Review on Prevention and Treatment of Aids
Pharmacy & Pharmacology International Journal Review Article Open Access A Review on prevention and treatment of aids Abstract Volume 5 Issue 1 - 2017 Human immunodeficiency virus (HIV) is a retrovirus which causes acquired immune Chinmaya keshari sahoo,1 Nalini kanta deficiency syndrome (AIDS) a condition where CD4+ cell count falls below 200 cells/ Sahoo,2 Surepalli Ram Mohan Rao,3 Muvvala µl and immune system begins to fail in humans leading to life threatening infections. 4 Many factors are associated with the sexual transmission of HIV causing AIDS. HIV Sudhakar 1 is transmitted by three main routes sexual contact, exposure to infected body fluids or Department of Pharmaceutics, Osmania University College of Technology, India tissues and from mother to child during pregnancy, delivery or breast feeding (vertical 2Department of Pharmaceutical Analysis and Quality assurance, transmission). Hence the efforts for prevention and control of HIV have to rely largely MNR College of Pharmacy, India on sexually transmitted disease (STD) control measures and AIDS. In the developing 3Mekelle University, Ethiopia countries both prevalence and incidence of AIDS are very high. The impact of AIDS 4Department of pharmaceutics, Malla Reddy College of on women’s health adversely affected by various reasons such as more susceptibility Pharmacy, India than men, asymptomatic nature of infection etc. The management of AIDS can be controlled by antiretroviral therapy, opportunistic infections and alternative medicine. Correspondence: Chinmaya keshari sahoo, Department of In present study is an update on origins of HIV, stages of HIV infection, transmission, Pharmaceutics, Osmania University College of Technology, India, diagnosis, prevention and management of AIDS. Email [email protected] Keywords: aids, HIV cd4+, vertical transmission, antiretroviral therapy Received: November 18, 2016 | Published: February 08, 2017 Abbreviations: HIV, human immunodeficiency virus; AIDS, bodily fluids such as saliva and tears do not transmit HIV. -
Lessons from Viral Superinfections for HIV-1 Vaccine Design Stephanie Jost* Ragon Institute of MGH, MIT and Harvard, USA
C S & lini ID ca A l f R o e l s Journal of a e n a r r Jost, J AIDS Clinic Res 2013, S3 c u h o J DOI: 10.4172/2155-6113.S3-005 ISSN: 2155-6113 AIDS & Clinical Research Review Article Open Access Lessons from Viral Superinfections for HIV-1 Vaccine Design Stephanie Jost* Ragon Institute of MGH, MIT and Harvard, USA Abstract Superinfection refers to a second viral infection in the context of a pre-existing adaptive immune response to prior infection with a viral strain that has not been cleared, the two viruses being genetically distinct yet belonging to the same genus. As such, this phenomenon provides unique settings to gain insights into the immune correlates of protection against HIV-1. The focus of this review is to discuss the current knowledge about immune responses to HIV-1 and to other viruses that are associated with partial or complete immunity to superinfection, or lack thereof, and how that could be applied to future HIV-1 vaccine strategies. Keywords: HIV-1; Superinfection; Vaccine; Co-infection; Viral HIV-1 Rapid Evolution and Diversity: A Challenge for infection; Recombination Vaccine Design Introduction The extremely rapid evolution of the virus probably largely contributed to the failure or limited success of HIV-1 vaccines evaluated The human immunodeficiency virus type 1 (HIV-1) affects 34 to date [5]. HIV-1’s extensive genetic diversity was first brought to light million adults and children worldwide, and the ongoing spread of the around 1983, when full-length sequences of the virus became available, epidemic resulted in about 2.5 million new infections and 1.7 million and has since then expanded [6]. -
Hypervariable Region 3 Residues of HIV Type 1 Gp120 Involved in CCR5 Coreceptor Utilization: Therapeutic and Prophylactic Implications
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 4558–4562, April 1999 Medical Sciences Hypervariable region 3 residues of HIV type 1 gp120 involved in CCR5 coreceptor utilization: Therapeutic and prophylactic implications WEI-KUNG WANG,TIM DUDEK,MAX ESSEX, AND TUN-HOU LEE* Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115 Communicated by Elkan R. Blout, Harvard Medical School, Cambridge, MA, February 17, 1999 (received for review November 2, 1998) ABSTRACT Crystallographic characterization of a ter- The coreceptor binding step of the HIV-1 life cycle is a nary complex containing a monomeric gp120 core, parts of potential target for therapeutic and prophylactic interventions. CD4, and a mAb, revealed a region that bridges the inner and To design intervention strategies targeting this critical step of outer domains of gp120. In a related genetic study, several HIV-1 entry requires knowing how V3 works in concert with residues conserved among primate lentiviruses were found to those residues in the bridging sheet to interact with CCR5, the play important roles in CC-chemokine receptor 5 (CCR5) chemokine coreceptor most often used by the so-called R5 coreceptor utilization, and all but one were mapped to the viruses of human and nonhuman primate lentiviruses (15, 16). bridging domain. To reconcile this finding with previous To that end, it is essential to provide a full account of V3 reports that the hypervariable region 3 (V3) of gp120 plays an residues involved in CCR5 utilization. In this study, we iden- important role in chemokine coreceptor utilization, elucidat- tified several V3 residues, both highly conserved and variable ing the roles of various V3 residues in this critical part of the ones, that were shown to play a role in CCR5 utilization. -
Using Knowledge of HIV Status As an HIV Prevention Strategy
From Prevention in Focus, Spring 2014 Unknown, negative or positive? Using knowledge of HIV status as an HIV prevention strategy By James Wilton and Tim Rogers As front-line workers in HIV prevention, it is important to understand what prevention strategies clients are using and how they understand the risks associated with them. A common HIV prevention strategy used by gay men and other men who have sex with men (MSM) is known as “serosorting” and involves limiting all – or just “high-risk” – sexual activities to partners who have the same HIV status. For example, an HIV-negative person may choose to only have condomless sex with other people who are HIV negative or an HIV-positive person may choose to only have condomless sex with other people who are HIV positive. This strategy is used in the context of different types of relationships, such as stable, casual, monogamous and non-monogamous relationships. This article focuses on how often serosorting is used, how well it works, and how knowledge of HIV status can be effectively used as a prevention strategy. The article only covers serosorting strategies that are based on individuals identifying themselves or others as HIV-positive or HIV-negative. It does not address other factors, such as viral load or use of other HIV prevention strategies, which play a very important role in assessing HIV risk. For information on these other strategies, please see the resource list at the end of the article. How common is serosorting? Serosorting is quite common among MSM in Canada and other parts of the world. -
Sexually Transmitted Diseases Treatment Guidelines, 2015
Morbidity and Mortality Weekly Report Recommendations and Reports / Vol. 64 / No. 3 June 5, 2015 Sexually Transmitted Diseases Treatment Guidelines, 2015 U.S. Department of Health and Human Services Centers for Disease Control and Prevention Recommendations and Reports CONTENTS CONTENTS (Continued) Introduction ............................................................................................................1 Gonococcal Infections ...................................................................................... 60 Methods ....................................................................................................................1 Diseases Characterized by Vaginal Discharge .......................................... 69 Clinical Prevention Guidance ............................................................................2 Bacterial Vaginosis .......................................................................................... 69 Special Populations ..............................................................................................9 Trichomoniasis ................................................................................................. 72 Emerging Issues .................................................................................................. 17 Vulvovaginal Candidiasis ............................................................................. 75 Hepatitis C ......................................................................................................... 17 Pelvic Inflammatory -
Use of a Home-Use Test to Diagnose HIV Infection in a Sex Partner: a Case Report David a Katz1*, Matthew R Golden2,3 and Joanne D Stekler2,3
Katz et al. BMC Research Notes 2012, 5:440 http://www.biomedcentral.com/1756-0500/5/440 CASE REPORT Open Access Use of a home-use test to diagnose HIV infection in a sex partner: a case report David A Katz1*, Matthew R Golden2,3 and Joanne D Stekler2,3 Abstract Background: Home-use HIV tests have the potential to increase testing and may be used by sex partners to inform sexual decision-making. To our knowledge, this is the first report of an individual diagnosed with HIV using a home-use test with a sex partner. Case presentation: We are conducting a randomized controlled trial of home self-testing for HIV using the OraQuick ADVANCEW HIV-1/2 Antibody Test on oral fluids. In 2011, a 27-year-old, homeless, Latino man who has sex with men not enrolled in the trial (the case) reported receiving a reactive result from a diverted study kit. When interviewed by study staff, the case reported that, 11 months prior, he had unprotected anal sex with a trial subject without discussing HIV status. Afterwards, the subject asked the case if he would like to test, performed the test, and disclosed the reactive result. The case reported altering his behavior to decrease the risk of HIV transmission to subsequent partners and sought care two months later. Conclusions: This case demonstrates that home-use HIV tests will be used by sex partners to learn and disclose HIV status and inform sexual decision-making. It also highlights concerns regarding the absence of counseling and the potential for delayed entry into HIV care. -
Guidelines for the Evaluation of Transfusion-Associated Infections
New York State Council on Human Blood and Transfusion Services GUIDELINES FOR THE EVALUATION OF TRANSFUSION-ASSOCIATED INFECTIONS Third Edition 2007 New York State Council on Human Blood and Transfusion Services New York State Department of Health Wadsworth Center Empire State Plaza; P.O. Box 509 Albany, New York 12201-0509 Third Edition 2007, Second Edition 1996, First Edition 1994 Requests for copies of this publication may be directed to: Blood and Tissue Resources Program New York State Department of Health Wadsworth Center Empire State Plaza P.O. Box 509 Albany, New York 12201-0509 Telephone: (518) 485-5341 Fax: (518) 485-5342 E-mail: [email protected] Website: www.wadsworth.org/labcert/blood_tissue NEW YORK STATE COUNCIL ON HUMAN BLOOD AND TRANSFUSION SERVICES Membership Roster – 2007 Donna Skerrett, M.D., M.S., Chairperson Kathleen Grima, M.D. Director Director Transfusion Medicine and Cellular Therapy New York Blood Center Clinical Services New York Presbyterian Hospital - White Plains, New York Weill Cornell Medical Center New York, New York Nadia Rajsz, M.S., MT(ASCP) Glen Spey, New York Joseph Chiofolo, D.O. Medical Director Lazaro Rosales, M.D. Transfusion Service Director Winthrop University Hospital Blood Bank Mineola, New York SUNY Health Science Center at Syracuse Robert A. Dracker, M.D., M.H.A. Syracuse, New York Medical Director Summerwood Pediatrics and Richard F. Daines, M.D. Infusacare Medical Services (Ex-officio) Liverpool, New York Commissioner New York State Department of Health William Fricke, M.D. Albany, New York Director Transfusion Service & Hematology Laboratory Jeanne V. Linden, M.D., M.P.H. -
KNOW HIV Prevention Education 2014 Revised Edition
KNOW 2014 Revised HIV PREVENTION Edition EDUCATION An HIV and AIDS Curriculum Manual FOR HEALTH FACILITY EMPLOYEES KNOW DOH 410-007 December 2014 John Weisman, Secretary For people with disabilities, this document is available on request in other formats. To submit a request, please call 1-800-525-0127 (TDD/TTY call 711). Page 1 KNOW Infectious Disease, HIV Prevention Section KNOW Curriculum 7th Edition Office of Infectious Disease Infectious Disease Prevention Section 310 Israel Road Tumwater, Washington 98501 (360) 236-3444 Edition 7- December 2014 revised and edited by Janee Moore MPH, Luke Syphard MPH, and David Heal MSW The 2014 KNOW Revision matches the outline of required topics for 4-hour and 7-hour licensing, which appear on the following page. Page 2 KNOW WASHINGTON STATE DEPARTMENT OF HEALTH OUTLINE OF HIV/AIDS CURRICULUM TOPICS Unless otherwise specified, all of the following six topic areas must be covered for professions with seven-hour licensing requirements. Selection of topics may be made to meet specific licensing boards' requirements. Topic areas I, II, V, and VI must be covered for the four- hour licensing requirements and for non-licensed health care facility employees who have no specific hourly requirements. Please consult the Department of Health (800-525-0127) with specific questions about hourly requirements. http://www.doh.wa.gov/LicensesPermitsandCertificates I. Etiology and epidemiology of HIV A. Etiology B. Reported AIDS cases in the United States and Washington State C. Risk populations/behaviors II. Transmission and infection control A. Transmission of HIV B. Infection Control Precautions C. Factors affecting risk for transmission D.