DOCSLIB.ORG

ANAVIP® Brochure

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ANAVIP® Brochure 11” NEW INDICATION ® EXPANDED ANAVIP [crotalidae immune F(ab')2 INDICATION (equine)] is an equine-derived antivenin indicated for the management of adult and pediatric Choose ANAVIP® to treat patients with North American North American Pit Viper Pit Viper envenomation. envenomation IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS None. WARNINGS AND PRECAUTIONS Hypersensitivity IT’S ANAVIP may cause allergic reactions. Patients with known allergies to horse protein are particularly at risk for an anaphylactic reaction. If signs or symptoms of anaphylaxis or hypersensitivity reactions (including ABOUT urticaria, rash, tightness of the chest, wheezing, hypotension) occur, discontinue immediately and institute 8.5” appropriate treatment. TIME Monitor patients with follow-up visits for signs and symptoms of delayed allergic reactions or serum sickness (rash, fever, myalgia, arthralgia, pruritus, urticarial rash) and treat appropriately if necessary. 1 Please see full Important Safety Information Reconstitutes in seconds on page 5 and accompanying full Prescribing Ready for dosing in minutes1 Information for ANAVIP. Circulates for weeks1 1 ANTIVENOM WITH TIME ON ITS SIDE Reconstitutes in seconds1 Ready for dosing in minutes1 Most envenomations were controlled within 4 hours2,a,b Low incidence of late venom effects up to 8 days1,b Circulates for weeks1 Shelf-life of 3 years2 Free replacements for future expiryc NOW INDICATED FOR ALL NORTH AMERICAN PIT VIPERS1 WATCH A DOSE GET + + PREPARED IN MINUTES NOW INDICATED FOR ALL NORTH ON ANAVIP.COM Copperhead Rattlesnake Cottonmouth a AMERICAN PIT VIPERS^1 Most patients (n=70 of 79) achieved initial control in 1 or 2 infusions. b The efficacy analysis did not meet the prespecified statistically defined superiority criterion. However, the percentages of subjects (N=114) showing prespecified criteria for coagulopathic effect on either Day 5 and/or Day 8 were 10.3% and 5.3% in the Groups 1 and 2 when compared to 29.7% in Group 3 indicating efficacy of ANAVIP in management of coagulopathic effect in patients with North American Pit Viper envenomation. c Replacement policy available in accordance with state laws. Please see full Important Safety Information on page 5 and accompanying full Prescribing Information for ANAVIP. 2 GO FROM SHELF TO SOLUTION IN MINUTES1 Standardized dosing with no scheduled maintenance1 Before dosing, please read Dosage and Administration in the full Prescribing Information Reconstitute each Infuse for ~60 minutes1 Evaluate 3 components of initial control 1 vial in 11.8 seconds1,a 2 3 for 60 minutes1 Local Coagulation Systemic Initial 10-vial dose injury not parameters symptoms progressing 10 vials 10 mL each improving resolved 25 to 50 mL/hr If tolerated, All 3 venom effects controlled? for 10 minutes increase X incrementally NO YES to 250 mL/hr until completion Administer another 10-vial dose Observe for 18 hours 250 mL Repeat as needed starting from Step 1 Only if symptoms re-emerge, administer a 4-vial dose diluted There is no known in 250 mL of sterile normal saline maximum dose of ANAVIP Store at room Use within 6 hours 1,b 1 temperature 6 of reconstitution hours aRange of 8 to 26 seconds per vial when using continuous gentle swirling with sterile normal saline. bUp to 25°C (77°F). Brief temperature excursions are permitted up to 40°C (104°F). Please see full Important Safety Information on page 5 and accompanying full Prescribing Information for ANAVIP. 3 DESIGNED TO CIRCULATE FOR WEEKS1 Antivenoms are not built the same 3,4 5 1,4 Fab Antivenom Whole IgG F(ab')2 — ANAVIP Papain Pepsin cleavage cleavage 50 kDa molecular mass Non-binding ˜ region 100 kDa molecular mass 15-hour elimination half-life ˜ 133-hour elimination half-life Venom-binding region A difference in half-life has been attributed to molecular mass4,5 Please see full Important Safety Information on page 5 and accompanying full Prescribing Information for ANAVIP. 4 IMPORTANT SAFETY INFORMATION INDICATION Transmissible Infectious Agents ® ANAVIP [crotalidae immune F(ab')2 (equine)] is an ANAVIP is made from equine (horse) plasma and may therefore equine-derived antivenin indicated for the management carry a risk of transmitting infectious agents, e.g., viruses. of adult and pediatric patients with North American Pit Viper envenomation. Reactions to Cresol Trace amounts of cresol from the manufacturing process are IMPORTANT SAFETY INFORMATION contained in ANAVIP. Localized reactions and generalized CONTRAINDICATIONS myalgias have been reported with the use of cresol as an None. injectable excipient. WARNINGS AND PRECAUTIONS ADVERSE REACTIONS Hypersensitivity The most common adverse reactions observed in more than ANAVIP may cause allergic reactions. 2 percent (2%) of patients in the clinical trials for ANAVIP were: pruritus, nausea, rash, arthralgia, peripheral edema, erythema, Patients with known allergies to horse protein are headache, myalgia, pain in extremity, and vomiting. particularly at risk for an anaphylactic reaction. If signs or symptoms of anaphylaxis or hypersensitivity References: 1. ANAVIP [crotalidae immune F(ab')2 (equine)] Prescribing Information. Rare Disease Therapeutics, Inc.; Franklin, TN. April 2021. 2. Data on file, Rare Disease Therapeutics, Inc. reactions (including urticaria, rash, tightness of the 3. CroFab [crotalidae polyvalent immune fab (ovine)] Prescribing Information. BTG International, Inc.; West Conshohocken, PA. August 2018. 4. World Health Organization. (2018). WHO Expert Committee chest, wheezing, hypotension) occur, discontinue on Biological Standardization: WHO TRS No 1004. ANNEX 5: Guidelines for the production, control and regulation of snake antivenom immunoglobulins; 2017. https://www.who.int/bloodproducts/ immediately and institute appropriate treatment. AntivenomGLrevWHO_TRS_1004_web_Annex_5.pdf Accessed March 26, 2021. 5. Gutiérrez JM, Leon G, Lomonte B. Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. Clin Pharmacokinet. 2003;42:721-741. Monitor patients with follow-up visits for signs and symptoms of delayed allergic reactions or serum sickness (rash, fever, myalgia, arthralgia, pruritus, Poison Control Center: 1-800-222-1222 To order ANAVIP or report urticarial rash) and treat appropriately suspected adverse reactions, if necessary. call: 1-844-4RareTx (1-844-472-7389) © Rare Disease Therapeutics, Inc. | ANV-CSB-002-E | May 2021 | HCPCS: J0841 Please see accompanying full Prescribing Information for ANAVIP. 5 PRESCRIBING INFORMATION HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ANAVIP safely and effectively. See full prescribing Snake Species Used for Standardization Minimum Mouse LD50 Units per Vial information for ANAVIP. Bothrops asper 780 1 ANAVIP® (Terciopelo or fer-de-lance) crotalidae immune F(ab’)2 (equine) Crotalus simus (formerly Crotalus durissus) 790 1 Lyophilized Powder for Solution for Injection (Central American Rattlesnake) For Intravenous Use Only Crotalus adamanteus 244 (Eastern Diamondback Rattlesnake) Initial U.S. Approval: 2015 Crotalus atrox 147 ------------------------------------------RECENT MAJOR CHANGES------------------------------------------- (Western Diamondback Rattlesnake) Indications and Usage (1) April 2021 Crotalus scutulatus 185 Dosage and Administration (2) April 2021 (Mohave Rattlesnake)2 Animal Toxicology and/or Pharmacology (13.2) April 2021 Agkistrodon contortrix 28 -------------------------------------------INDICATIONS AND USAGE------------------------------------------- (Copperhead) ANAVIP [crotalidae immune F(ab’)2 (equine)] is an equine-derived antivenin indicated for the Agkistrodon piscivorus 61 management of adult and pediatric patients with North American Pit Viper envenomation. (1) (Cottonmouth or Water Moccasin) 1The venom of these species is used in the manufacture of ANAVIP. --------------------------------------DOSAGE AND ADMINISTRATION--------------------------------------- 2The Mohave phenotype A is used for standardization. Intravenous use only. -----------------------------------------CONTRAINDICATIONS--------------------------------------------------- Dose No. of Vials Infusion Rate None. (4) Initial dose 10 vials Infuse intravenously over 60 minutes. ---------------------------------------WARNINGS AND PRECAUTIONS--------------------------------------- Additional dose(s) to 10 vials Infuse intravenously over 60 minutes. • ANAVIP may cause allergic reactions. achieve initial control (as needed) o Patients with known allergies to horse protein are particularly at risk for an anaphylactic Observation and late 4 vials Infuse intravenously over 60 minutes. reaction. If signs or symptoms of anaphylaxis or hypersensitivity reactions (including dosing urticaria, rash, tightness of the chest, wheezing, hypotension) occur, discontinue immediately and institute appropriate treatment. • Initiate administration as soon as possible after North American Pit Viper bite in patients who o Monitor patients with follow-up visits for signs and symptoms of delayed allergic reactions develop signs of envenomation (e.g., local injury, coagulation abnormality, or systemic signs or serum sickness (rash, fever, myalgia, arthralgia, pruritus, urticarial rash) and treat of envenomation). (2) appropriately if necessary. (5.1) • Monitor patients in a health care setting at least 18 hours following initial control of signs and • ANAVIP is made from equine plasma and may contain infectious agents, e.g., viruses. (5.2) symptoms.
Load more

Recommended publications
  • Diversity-Dependent Cladogenesis Throughout Western Mexico: Evolutionary Biogeography of Rattlesnakes (Viperidae: Crotalinae: Crotalus and Sistrurus)
    City University of New York (CUNY) CUNY Academic Works Publications and Research New York City College of Technology 2016 Diversity-dependent cladogenesis throughout western Mexico: Evolutionary biogeography of rattlesnakes (Viperidae: Crotalinae: Crotalus and Sistrurus) Christopher Blair CUNY New York City College of Technology Santiago Sánchez-Ramírez University of Toronto How does access to this work benefit ou?y Let us know! More information about this work at: https://academicworks.cuny.edu/ny_pubs/344 Discover additional works at: https://academicworks.cuny.edu This work is made publicly available by the City University of New York (CUNY). Contact: [email protected] 1Blair, C., Sánchez-Ramírez, S., 2016. Diversity-dependent cladogenesis throughout 2 western Mexico: Evolutionary biogeography of rattlesnakes (Viperidae: Crotalinae: 3 Crotalus and Sistrurus ). Molecular Phylogenetics and Evolution 97, 145–154. 4 https://doi.org/10.1016/j.ympev.2015.12.020. © 2016. This manuscript version is made 5 available under the CC-BY-NC-ND 4.0 license. 6 7 8 Diversity-dependent cladogenesis throughout western Mexico: evolutionary 9 biogeography of rattlesnakes (Viperidae: Crotalinae: Crotalus and Sistrurus) 10 11 12 CHRISTOPHER BLAIR1*, SANTIAGO SÁNCHEZ-RAMÍREZ2,3,4 13 14 15 1Department of Biological Sciences, New York City College of Technology, Biology PhD 16 Program, Graduate Center, The City University of New York, 300 Jay Street, Brooklyn, 17 NY 11201, USA. 18 2Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks 19 Street, Toronto, ON, M5S 3B2, Canada. 20 3Department of Natural History, Royal Ontario Museum, 100 Queen’s Park, Toronto, 21 ON, M5S 2C6, Canada. 22 4Present address: Environmental Genomics Group, Max Planck Institute for 23 Evolutionary Biology, August-Thienemann-Str.
    [Show full text]
  • Review Article Distribution and Conservation Status of Amphibian
    Mongabay.com Open Access Journal - Tropical Conservation Science Vol.7 (1):1-25 2014 Review Article Distribution and conservation status of amphibian and reptile species in the Lacandona rainforest, Mexico: an update after 20 years of research Omar Hernández-Ordóñez1, 2, *, Miguel Martínez-Ramos2, Víctor Arroyo-Rodríguez2, Adriana González-Hernández3, Arturo González-Zamora4, Diego A. Zárate2 and, Víctor Hugo Reynoso3 1Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México; Av. Universidad 3000, C.P. 04360, Coyoacán, Mexico City, Mexico. 2 Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, Antigua Carretera a Pátzcuaro No. 8701, Ex Hacienda de San José de la Huerta, 58190 Morelia, Michoacán, Mexico. 3Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico. 4División de Posgrado, Instituto de Ecología A.C. Km. 2.5 Camino antiguo a Coatepec No. 351, Xalapa 91070, Veracruz, Mexico. * Corresponding author: Omar Hernández Ordóñez, email: [email protected] Abstract Mexico has one of the richest tropical forests, but is also one of the most deforested in Mesoamerica. Species lists updates and accurate information on the geographic distribution of species are necessary for baseline studies in ecology and conservation of these sites. Here, we present an updated list of the diversity of amphibians and reptiles in the Lacandona region, and actualized information on their distribution and conservation status. Although some studies have discussed the amphibians and reptiles of the Lacandona, most herpetological lists came from the northern part of the region, and there are no confirmed records for many of the species assumed to live in the region.
    [Show full text]
  • Venom Week VI
    Toxicon 150 (2018) 315e334 Contents lists availableHouston, at ScienceDirect TX, respectively. Toxicon journal homepage: www.elsevier.com/locate/toxicon Venom Week VI Texas A&M University, Kingsville, March 14-18, 2018 North American Society of Toxinology Venom Week VII will be held in 2020 at the University of Florida, Gain- Abstract Editors: Daniel E. Keyler, Pharm.D., FAACT and Elda E. Sanchez, esville, Florida, and organized by Drs. Alfred Alequas and Michael Schaer. Ph.D. Venom Week VI was held at Texas A&M University, Kingsville, Texas, and Appreciation is extended to Elsevier and Toxicon for their excellent sup- was sponsored by the North American Society of Toxinology. The meeting port, and to all Texas A&M University, Kingsville staff for their outstanding was attended by 160 individuals, including 14 invited speakers, and rep- contribution and efforts to make Venom Week VI a success. resenting eight different countries including the United States. Dr. Elda E. Sanchez was the meeting Chair along with meeting coordinators Drs. Daniel E. Keyler, University of Minnesota and Steven A. Seifert, University of New Mexico, USA. Abstracts Newly elected NAST officers were announced and welcomed: President, Basic and translational research IN Carl-Wilhelm Vogel MD, PhD; Secretary, Elda E. Sanchez, PhD; and Steven THIRD GENERATION ANTIVENOMICS: PUSHING THE LIMITS OF THE VITRO A. Seifert, Treasurer. PRECLINICAL ASSESSMENT OF ANTIVENOMS * Invited Speakers: D. Pla, Y. Rodríguez, J.J. Calvete . Evolutionary and Translational Venomics Glenn King, PhD, University of Queensland, Australia, Editor-in-Chief, Lab, Biomedicine Institute of Valencia, Spanish Research Council, 46010 Toxicon; Keynote speaker Valencia, Spain Bruno Lomonte, PhD, Instituto Clodomiro Picado, University of Costa Rica * Corresponding author.
    [Show full text]
  • Xenosaurus Tzacualtipantecus. the Zacualtipán Knob-Scaled Lizard Is Endemic to the Sierra Madre Oriental of Eastern Mexico
    Xenosaurus tzacualtipantecus. The Zacualtipán knob-scaled lizard is endemic to the Sierra Madre Oriental of eastern Mexico. This medium-large lizard (female holotype measures 188 mm in total length) is known only from the vicinity of the type locality in eastern Hidalgo, at an elevation of 1,900 m in pine-oak forest, and a nearby locality at 2,000 m in northern Veracruz (Woolrich- Piña and Smith 2012). Xenosaurus tzacualtipantecus is thought to belong to the northern clade of the genus, which also contains X. newmanorum and X. platyceps (Bhullar 2011). As with its congeners, X. tzacualtipantecus is an inhabitant of crevices in limestone rocks. This species consumes beetles and lepidopteran larvae and gives birth to living young. The habitat of this lizard in the vicinity of the type locality is being deforested, and people in nearby towns have created an open garbage dump in this area. We determined its EVS as 17, in the middle of the high vulnerability category (see text for explanation), and its status by the IUCN and SEMAR- NAT presently are undetermined. This newly described endemic species is one of nine known species in the monogeneric family Xenosauridae, which is endemic to northern Mesoamerica (Mexico from Tamaulipas to Chiapas and into the montane portions of Alta Verapaz, Guatemala). All but one of these nine species is endemic to Mexico. Photo by Christian Berriozabal-Islas. Amphib. Reptile Conserv. | http://redlist-ARC.org 01 June 2013 | Volume 7 | Number 1 | e61 Copyright: © 2013 Wilson et al. This is an open-access article distributed under the terms of the Creative Com- mons Attribution–NonCommercial–NoDerivs 3.0 Unported License, which permits unrestricted use for non-com- Amphibian & Reptile Conservation 7(1): 1–47.
    [Show full text]
  • Pit Vipers: from Fang to Needle—Three Critical Concepts for Clinicians
    Tuesday, July 28, 2021 Pit Vipers: From Fang to Needle—Three Critical Concepts for Clinicians Keith J. Boesen, PharmD & Nicholas B. Hurst, M.D., MS Disclosures / Potential Conflicts of Interest • Keith Boesen and Nicholas Hurst are employed by Rare Disease Therapeutics, Inc. (RDT) • RDT is a U.S. company working with Laboratorios Silanes, S.A. de C.V., a company in Mexico • Laboratorios Silanes manufactures a variety of antivenoms Note: This program may contain the mention of suppliers, brands, products, services or drugs presented in a case study or comparative format using evidence-based research. Such examples are intended for educational and informational purposes and should not be perceived as an endorsement of any particular supplier, brand, product, service or drug. 2 Learning Objectives At the end of this session, participants should be able to: 1. Describe the venom variability in North American Pit Vipers 2. Evaluate the clinical symptoms associated with a North American Pit Viper envenomation 3. Develop a treatment plan for a North American Pit Viper envenomation 3 Audience Poll Question: #1 of 5 My level of expertise in treating Pit Viper Envenomation is… a. I wouldn’t know where to begin! b. I have seen a few cases… c. I know a thing or two because I’ve seen a thing or two d. I frequently treat these patients e. When it comes to Pit Viper envenomation, I am a Ssssuper Sssskilled Ssssnakebite Sssspecialist!!! 4 PIT VIPER ENVENOMATIONS PIT VIPERS Loreal Pits Movable Fangs 1. Russel 1983 -Photo provided by the Arizona Poison and Drug Information Center 1.
    [Show full text]
  • Mating in Free-Ranging Neotropical Rattlesnakes, Crotalus Durissus: Is It Risky for Males?
    Herpetology Notes, volume 14: 225-227 (2021) (published online on 01 February 2021) Mating in free-ranging Neotropical rattlesnakes, Crotalus durissus: Is it risky for males? Selma Maria Almeida-Santos1,*, Thiago Santos2, and Luis Miguel Lobo1 Field observations of the mating behaviour of snakes The male remained stretched out for about 20 minutes are scarce, probably because of the secretive nature and and showed no defensive posture even with the presence low encounter rates of many species (Sasa and Curtis, of the observer. We then noticed drops of blood on the 2006). In the Neotropical rattlesnake, Crotalus durissus vegetation and the hemipenis (Fig. 1 E-F). We could not Linnaeus, 1758, mating has been reported only in determine the origin of the blood, but we suggest two captive individuals (Almeida-Santos et al., 1999). Here nonexclusive hypotheses. The hemipenis spicules may we describe the first record of the mating behaviour of have hurt the female’s vagina while she was dragging the the Neotropical rattlesnake, Crotalus durissus, in nature male over a long distance. Alternatively, the male may (Fig. 1 A). have suffered an injury to the hemipenis while being Observations were made on 9 March 2017, at 14:54 h, dragged quickly by the female. The slow hemipenis a warm and sunny day (temperature = 27.1 oC; relative retraction and the male’s fatigue after copulation may humidity = 66%), in an ecotone between dry forest and better support the second hypothesis. Cerrado (Brazilian savannah) in Prudente de Morais, Potential costs for male C. durissus during mating Minas Gerais, Brazil (-19.2841 °S,-44.0628 °W; datum season include increased activity and energy expenditure WGS 84).
    [Show full text]
  • Reptiles and Amphibians of Lamanai Outpost Lodge, Belize
    Reptiles and Amphibians of the Lamanai Outpost Lodge, Orange Walk District, Belize Ryan L. Lynch, Mike Rochford, Laura A. Brandt and Frank J. Mazzotti University of Florida, Fort Lauderdale Research and Education Center; 3205 College Avenue; Fort Lauderdale, Florida 33314 All pictures taken by RLL: [email protected] and MR: [email protected] Vaillant’s Frog Rio Grande Leopard Frog Common Mexican Treefrog Rana vaillanti Rana berlandieri Smilisca baudinii Veined Treefrog Red Eyed Treefrog Stauffer’s Treefrog Phrynohyas venulosa Agalychnis callidryas Scinax staufferi White-lipped Frog Fringe-toed Foam Frog Fringe-toed Foam Frog Leptodactylus labialis Leptodactylus melanonotus Leptodactylus melanonotus 1 Reptiles and Amphibians of the Lamanai Outpost Lodge, Orange Walk District, Belize Ryan L. Lynch, Mike Rochford, Laura A. Brandt and Frank J. Mazzotti University of Florida, Fort Lauderdale Research and Education Center; 3205 College Avenue; Fort Lauderdale, Florida 33314 All pictures taken by RLL: [email protected] and MR: [email protected] Tungara Frog Marine Toad Gulf Coast Toad Physalaemus pustulosus Bufo marinus Bufo valliceps Sheep Toad House Gecko Dwarf Bark Gecko Hypopachus variolosus Hemidactylus frenatus Shaerodactylus millepunctatus Turnip-tailed Gecko Yucatan Banded Gecko Yucatan Banded Gecko Thecadactylus rapicaudus Coleonyx elegans Coleonyx elegans 2 Reptiles and Amphibians of the Lamanai Outpost Lodge, Orange Walk District, Belize Ryan L. Lynch, Mike Rochford, Laura A. Brandt and Frank J. Mazzotti University
    [Show full text]
  • Rattlesnake Tales 127
    Hamell and Fox Rattlesnake Tales 127 Rattlesnake Tales George Hamell and William A. Fox Archaeological evidence from the Northeast and from selected Mississippian sites is presented and combined with ethnographic, historic and linguistic data to investigate the symbolic significance of the rattlesnake to northeastern Native groups. The authors argue that the rattlesnake is, chief and foremost, the pre-eminent shaman with a (gourd) medicine rattle attached to his tail. A strong and pervasive association of serpents, including rattlesnakes, with lightning and rainfall is argued to have resulted in a drought-related ceremo- nial expression among Ontario Iroquoians from circa A.D. 1200 -1450. The Rattlesnake and Associates Personified (Crotalus admanteus) rattlesnake man-being held a special fascination for the Northern Iroquoians Few, if any of the other-than-human kinds of (Figure 2). people that populate the mythical realities of the This is unexpected because the historic range of North American Indians are held in greater the eastern diamondback rattlesnake did not esteem than the rattlesnake man-being,1 a grand- extend northward into the homeland of the father, and the proto-typical shaman and warrior Northern Iroquoians. However, by the later sev- (Hamell 1979:Figures 17, 19-21; 1998:258, enteenth century, the historic range of the 264-266, 270-271; cf. Klauber 1972, II:1116- Northern Iroquoians and the Iroquois proper 1219) (Figure 1). Real humans and the other- extended southward into the homeland of the than-human kinds of people around them con- eastern diamondback rattlesnake. By this time the stitute a social world, a three-dimensional net- Seneca and other Iroquois had also incorporated work of kinsmen, governed by the rule of reci- and assimilated into their identities individuals procity and with the intensity of the reciprocity and families from throughout the Great Lakes correlated with the social, geographical, and region and southward into Virginia and the sometimes mythical distance between them Carolinas.
    [Show full text]
  • Patterns in Protein Components Present in Rattlesnake Venom: a Meta-Analysis
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 1 September 2020 doi:10.20944/preprints202009.0012.v1 Article Patterns in Protein Components Present in Rattlesnake Venom: A Meta-Analysis Anant Deshwal1*, Phuc Phan2*, Ragupathy Kannan3, Suresh Kumar Thallapuranam2,# 1 Division of Biology, University of Tennessee, Knoxville 2 Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville 3 Department of Biological Sciences, University of Arkansas, Fort Smith, Arkansas # Correspondence: [email protected] * These authors contributed equally to this work Abstract: The specificity and potency of venom components gives them a unique advantage in development of various pharmaceutical drugs. Though venom is a cocktail of proteins rarely is the synergy and association between various venom components studied. Understanding the relationship between various components is critical in medical research. Using meta-analysis, we found underlying patterns and associations in the appearance of the toxin families. For Crotalus, Dis has the most associations with the following toxins: PDE; BPP; CRL; CRiSP; LAAO; SVMP P-I & LAAO; SVMP P-III and LAAO. In Sistrurus venom CTL and NGF had most associations. These associations can be used to predict presence of proteins in novel venom and to understand synergies between venom components for enhanced bioactivity. Using this approach, the need to revisit classification of proteins as major components or minor components is highlighted. The revised classification of venom components needs to be based on ubiquity, bioactivity, number of associations and synergies. The revised classification will help in increased research on venom components such as NGF which have high medical importance. Keywords: Rattlesnake; Crotalus; Sistrurus; Venom; Toxin; Association Key Contribution: This article explores the patterns of appearance of venom components of two rattlesnake genera: Crotalus and Sistrurus to determine the associations between toxin families.
    [Show full text]
  • Crotalus Cerastes (Hallowell, 1854) (Squamata, Viperidae)
    Herpetology Notes, volume 9: 55-58 (2016) (published online on 17 February 2016) Arboreal behaviours of Crotalus cerastes (Hallowell, 1854) (Squamata, Viperidae) Andrew D. Walde1,*, Andrea Currylow2, Angela M. Walde1 and Joel Strong3 Crotalus cerastes (Hallowell, 1854) is a small study area has no uninterrupted sandy areas outside of horned rattlesnake that ranges throughout most of the ephemeral washes, and no dune-like habitats. It is in deserts of southwestern United States, and south into this scrub-like habitat that we made three observations northern Mexico (Ernst and Ernst, 2003). This species of the previously undocumented arboreal behaviour of is considered to be a psammophilous (sand-dune) C. cerastes. specialist, typically inhabiting loose sand habitats and On 7 April 2005 at 1618h, we observed an adult C. dune blowouts (Ernst and Ernst, 2003). Although C. cerastes coiled in an A. dumosa shrub approximately 25 cerastes is primarily a nocturnal snake, it is known to cm above the ground (Fig. 1 A). The air temperature be active diurnally in the spring, and to bask in early was 21 °C and ground temperature was 27 °C. The morning or late afternoon (Ernst and Ernst, 2003). snake did not attempt to flee at our approach, but did This rattlesnake species exhibits a unique style of reposition slightly in the branches. A second observation locomotion known as sidewinding, from which it occurred on 18 April 2005 at 1036h, when we observed derives its common name, Sidewinder. Sidewinding is another adult C. cerastes extending the anterior third of believed to be an adaptation to efficiently move in loose its body beyond the top of an A.
    [Show full text]
  • Toxin Transcripts in Crotalus Atrox Venom and in Silico Structures of Toxins
    University of Texas Rio Grande Valley ScholarWorks @ UTRGV Biology Faculty Publications and Presentations College of Sciences 6-17-2020 Toxin transcripts in Crotalus atrox venom and in silico structures of toxins Ying Jia The University of Texas Rio Grande Valley Ivan Lopez The University of Texas Rio Grande Valley Paulina Kowalski The University of Texas Rio Grande Valley Follow this and additional works at: https://scholarworks.utrgv.edu/bio_fac Part of the Animal Sciences Commons, Biology Commons, and the Pharmacology, Toxicology and Environmental Health Commons Recommended Citation Jia Y, Lopez I, Kowalski P. Toxin transcripts in Crotalus atrox venom and in silico structures of toxins. J Venom Res. 2020 Jun 17;10:18-22. This Article is brought to you for free and open access by the College of Sciences at ScholarWorks @ UTRGV. It has been accepted for inclusion in Biology Faculty Publications and Presentations by an authorized administrator of ScholarWorks @ UTRGV. For more information, please contact [email protected], [email protected]. ISSN: 2044-0324 J Venom Res, 2020, Vol 10, 18-22 RESEARCH REPORT Toxin transcripts in Crotalus atrox venom and in silico structures of toxins Ying Jia*, Ivan Lopez and Paulina Kowalski Biology Department, The University of Texas Rio Grande Valley, Brownsville, Texas 78520, USA *Correspondence to: Ying Jia, Email: [email protected] Received: 16 May 2020 | Revised: 15 June 2020 | Accepted: 16 June 2020 | Published: 17 June 2020 © Copyright The Author(s). This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
    [Show full text]
  • Other Contributions
    Other Contributions NATURE NOTES Amphibia: Gymnophiona Gymnopis multiplicata. Size. The distribution of G. multiplicata extends from southeastern Guatemala to western Panama, on the Atlantic versant, and on the Pacific versant from northwestern Costa Rica to western Panama, at el- evations from sea level to 1,400 m (McCranie and Wilson, 2002). Wake (1988) provided a definition and diagnosis for the genus Gymnopis, which then was considered monotypic, and indicated the maximum total length (TOL) as “to 500 mm” (= 50 cm). Savage (2002) reported the maximum TOL of G. multiplicata as “to 480 mm” (= 48 cm). The longest specimen presently in the museum collection at the University of Costa Rica (UCR 17096) measures 47.4 cm. Róger Blanco, the research coordinator of Área de Conservación Guanacaste, informed me that at Sector Santa Rosa, Provincia de Guanacaste, Costa Rica, the rainfall recorded A during the rainy season of 2010 (2,819.3 mm) was more than twice the amount that fell the pre- vious year. A portion of the park’s administrative area remained flooded throughout much of the rainy season, which made the soil softer than usual, and under these condi- tions on 21 November 2010, Johan Vargas and Roberto Espinoza col- lected a very large G. multiplicata (Figs. 1A, Fig. 1. (A) The large B B). The individual mea- Gymnopis mexicanus sured 56 cm in TOL and found in Sector 6 cm in circumference at Santa Rosa on 25 midbody. Because of its November 2010; and possible record length, (B) a close-up of the the caecilian was main- anterior portion of its body.
    [Show full text]