Adult Heart Transplant Handbook

Total Page:16

File Type:pdf, Size:1020Kb

Adult Heart Transplant Handbook THE ADULT HEART TRANSPLANT HANDBOOK A REFERENCE GUIDE FOR HEART TRANSPLANT RECIPIENTS, THEIR FAMILIES, AND CAREGIVERS. This reference guide belongs to: Patient Name: Transplant Date: HEART TRANSPLANT PROGRAM Cedars-Sinai Medical Center Advanced Health Sciences Pavilion 127 S. San Vicente Blvd., Suite A6100 Los Angeles, CA 90048 USA Tel: (310) 423-5460 Fax: (310) 423-0852 www.cedars-sinai.edu/heart In the event this handbook is lost and found, please be advised: The information contained herein is considered Protected Health Information (PHI) and is protected under applicable law. This personal identifiable health information is private, confidential, and privileged. Any review, dissemination, distribution, or disclosure in any manner whatsoever is strictly prohibited and violations committed thereon are prosecuted. Upon immediate determination that handbook has been lost, please secure its safety and call the Heart Transplant Program at (310) 423-5460 and arrange for its return at the expense of the hospital. Thank you for your cooperation. Foreward 5 PREFACE This handbook is designed to provide a better understanding of the heart transplant program, the associated postoperative recovery, and the lifetime follow-up care required of all heart transplant recipients. Please consult with a transplant nurse coordinator, transplant cardiologist, or other appropriate clinician to assist you in finding answers to the questions you could not find in this handbook. Contents 7 TABLE OF CONTENTS PREFACE .......................................................................................... 5 TABLE OF CONTENTS ..................................................................... 7 WELCOME ...................................................................................... 11 HEART TRANSPLANT FACULTY & STAFF ................................... 13 Transplant Cardiologists .............................................................13 Transplant Surgeons ...................................................................14 Transplant Psychiatry ................................................................. 14 Nurse Transplant Coordinators ................................................... 14 Transplant & Heart Failure Nurse Practitioners ........................... 15 Transplant Social Workers ........................................................ 166 Transplant Financial Coordinators .............................................. 16 Transplant Clinical Pharmacology ............................................... 16 Transplant Nutrition and Dietetics ............................................... 17 Patient Service Representatives ................................................. 17 Transplant Clinic Nurses .............................................................17 Administrators .............................................................................1 8 Advanced Heart Disease Center – P a tie nt Clinic ........................ 18 Answering Service ......................................................................1 8 HEART TRANSPLANTATION AT CEDARS-SINAI ........................ 19 TRANSPLANT EVALUATION ........................................................ 21 Laboratory Tests .........................................................................21 Diagnostic Tests .........................................................................22 Me dica l & S urgica l Eva lua tion ............................................... 22 Psychosocial Evaluation ........................................................ 23 Psychiatric Evaluation ........................................................... 23 Dental Evaluation ..................................................................23 Nutrition Evaluation ...............................................................23 Fina ncia l Eva lua tion ..............................................................24 Decision Making Process ............................................................25 GENERAL SURGICAL RISKS .......................................................... 27 EARLY PROBLEMS OF TRANSPLANT .......................................... 29 Re na l Fa ilure .........................................................................29 Rejection ...............................................................................29 Acute Rejection .....................................................................29 Chronic Rejection ..................................................................29 CONSIDERATIONS ........................................................................ 31 Alternative Treatments .......................................................... 31 Protected Health Information ................................................. 31 Potential Medical/Psychosocial Risks .................................... 31 National Results and Transplant Center-Specific Outcomes . 31 Medicare Notification and Outcome Requirements ................ 31 Health and Life Insurance ..................................................... 32 Contents 8 Right to Refuse Transplant .................................................... 32 Te a ching Fa cility ...................................................................32 Waiting Time Transfer and Multiple Listing ............................ 32 Concerns or Grievances ........................................................ 32 Program Coverage ................................................................33 WA I TI NG FOR A HEART ................................................................ 35 National Waiting List ...................................................................35 Waiting List Status ................................................................35 Multiple Lis ting Option ...........................................................36 Waiting period .......................................................................36 Wa iting Time .........................................................................36 Listed Patient Responsibilities..................................................... 37 Insurance Approval and Insurance Changes ............................... 37 Organ Donors .............................................................................37 High Risk Donors ..................................................................38 Donor Privacy .......................................................................39 The Matching Process...........................................................39 HEART TRANSPLANT EVENT ....................................................... 41 Orga n Offe r ...........................................................................41 Organ Donor Related Risks .................................................. 41 Transplant Notification...........................................................41 ANATOMY OF THE HEART ........................................................... 43 HEART TRANSPLANT SURGERY .................................................. 45 ICU Nurs ing S ta ff ..................................................................46 ICU Expectations ..................................................................46 Length of Stay .......................................................................47 CLINIC AND YEARLY VISITS ......................................................... 49 Diagnostic Invasive Procedures .................................................. 49 Right Heart Catheterization (RHC) and Endomyocardial Biopsy 49 Left Heart Catheterization (LHC) or Angiogram ..................... 50 Intravascular Ultrasound (IVUS) ............................................ 51 Diagnostic Non-Invasive Procedures & Testing .......................... 51 Echocardiogram (Echo) .........................................................52 Electrocardiogram (EKG) ...................................................... 52 Blood Work ...........................................................................52 MEDICATIONS ............................................................................... 53 Anti-Rejection Medication (Immunosuppression) ........................ 53 Neoral® or Gengraf® (Cyclosporine) .................................... 53 Prograf® (Tacrolimus) ........................................................... 54 CellCept® (Mycophenolate Mofetil) ....................................... 54 Rapamune ® (Sirolimus) ....................................................... 55 Zortress® (Everolimus) .........................................................55 Prednisone ............................................................................55 Infe ction-Fighting Medications..................................................... 56 Bactrim SS® (Trimethoprim/Sulfamethoxazole) .................... 56 Contents 9 Valcyte® (Valganciclovir) ...................................................... 56 Clotrimazole® .......................................................................57 Over-the-Counter Medications .................................................... 57 Constipation ..........................................................................57 Diarrhea ................................................................................57 Headaches, Muscle Aches, and Pain .................................... 57 Allergy/Cold Symptoms .........................................................57 Indigestion/Heartburn ............................................................58 S le e p Aids .............................................................................58
Recommended publications
  • Surgical Advances in Heart and Lung Transplantation
    Anesthesiology Clin N Am 22 (2004) 789–807 Surgical advances in heart and lung transplantation Eric E. Roselli, MD*, Nicholas G. Smedira, MD Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Desk F25, 9500 Euclid Avenue, Cleveland, OH 44195, USA The first heart transplants were performed in dogs by Alexis Carrel and Charles Guthrie in 1905, but it was not until the 1950s that attempts at human orthotopic heart transplant were reported. Several obstacles, including a clear definition of brain death, adequate organ preservation, control of rejection, and an easily reproducible method of implantation, slowed progress. Eventually, the first successful human to human orthotopic heart transplant was performed by Christian Barnard in South Africa in 1967 [1]. Poor healing of bronchial anastomoses hindered early progress in lung transplantation, first reported in 1963 [2]. The first successful transplant of heart and both lungs was accomplished at Stanford University School of Medicine (Stanford, CA) in 1981 [3]. The introduction of cyclosporine to immunosuppres- sion protocols, with lower doses of steroids, led to the first successful isolated lung transplant, performed at Toronto General Hospital in 1983 [4]. Since these early successes at thoracic transplantation, great progress has been made in the care of patients with end-stage heart and lung disease. Although only minor changes have occurred in surgical technique for heart and lung transplantation, the greatest changes have been in liberalizing donor criteria to expand the donor pool. This article focuses on more recent surgical advances in donor selection and management, procurement and implantation, and the impact these advances have had on patient outcome.
    [Show full text]
  • MD Anderson Lodging
    All information is subject to change! For the latest lodging information see http://joeshouse.org/Lodging/tabid/115/Default.aspx?hid=184&state=Texas MD Anderson Lodging List - Other Name Address Phone Amenities Notes Reservations Rates Distance American Various Hotels 888 227 6333 Varies with ACS along with local hotels provide T0 request hotel Some hotels offer Varies with Cancer Society’s hotel overnight accommodations to cancer lodging, please contact free nights, others hotel Hotel Partners patients who travel for outpatient the American Cancer offer rooms at Program treatment. All accommodations are Society at 877-227- discounted rates. provided based on eligibility 1618. Requests for Patients are requirements, are subject to lodging are met on a responsible for all availability and restrictions imposed first-come, first-served additional charges, by the participating hotels. Special basis and must be other than the room requests, such as pet-friendly and submitted at least two- charge…i.e. shuttle services, are taken into weeks prior to the date parking fees, room consideration if mentioned. lodging is needed. service, etc. Name Address Phone Amenities Notes Reservations Rates Distance Ronald 1907 713.795.3500 LF, NS, P, I, ** Temporarily closed to new A health care provider Requested rate - .4 Miles MacDonald Holcombe patients due to COVID-19 ** Ronald or state social worker $25.00 per night., House Blvd, Houston, Microwave McDonald House is a "home away must refer families however no family TX 77030 Refrigerator from home" for families and children staying for the first is turned away due Free Local being treated at Texas Medical time.
    [Show full text]
  • Signal Processing Techniques for Phonocardiogram De-Noising and Analysis
    -3C).1 CBME CeaEe for Bionedio¡l Bnginocdng Adelaide Univenity Signal Processing Techniques for Phonocardiogram De-noising and Analysis by Sheila R. Messer 8.S., Urriversity of the Pacific, Stockton, California, IJSA Thesis submitted for the degree of Master of Engineering Science ADELAIDE U N IVERSITY AUSTRALIA Adelaide University Adelaide, South Australia Department of Electrical and Electronic Faculty of Engineering, Computer and Mathematical Sciences July 2001 Contents Abstract vi Declaration vll Acknowledgement vul Publications lx List of Figures IX List of Tables xlx Glossary xxii I Introduction I 1.1 Introduction 2 t.2 Brief Description of the Heart 4 1.3 Heart Sounds 7 1.3.1 The First Heart Sound 8 1.3.2 The Second Heart Sound . 8 1.3.3 The Third and Fourth Heart Sounds I I.4 Electrical Activity of the Heart I 1.5 Literature Review 11 1.5.1 Time-Flequency and Time-Scale Decomposition Based De-noising 11 I CO]VTE]VTS I.5.2 Other De-noising Methods t4 1.5.3 Time-Flequency and Time-Scale Analysis . 15 t.5.4 Classification and Feature Extraction 18 1.6 Scope of Thesis and Justification of Research 23 2 Equipment and Data Acquisition 26 2.1 Introduction 26 2.2 History of Phonocardiography and Auscultation 26 2.2.L Limitations of the Hurnan Ear 26 2.2.2 Development of the Art of Auscultation and the Stethoscope 28 2.2.2.L From the Acoustic Stethoscope to the Electronic Stethoscope 29 2.2.3 The Introduction of Phonocardiography 30 2.2.4 Some Modern Phonocardiography Systems .32 2.3 Signal (ECG/PCG) Acquisition Process .34 2.3.1 Overview of the PCG-ECG System .34 2.3.2 Recording the PCG 34 2.3.2.I Pick-up devices 34 2.3.2.2 Areas of the Chest for PCG Recordings 37 2.3.2.2.I Left Ventricle Area (LVA) 37 2.3.2.2.2 Right Ventricular Area (RVA) 38 oaooe r^fr /T ce a.!,a.2.{ !v¡u Ãurlo¡^+-;^l ¡rr!o^-^^ \!/ ^^\r¡ r/ 2.3.2.2.4 Right Atrial Area (RAA) 38 2.3.2.2.5 Aortic Area (AA) 38 2.3.2.2.6 Pulmonary Area (PA) 39 ll CO]VTE]VTS 2.3.2.3 The Recording Process .
    [Show full text]
  • Transplant Immunology.Pdf
    POLICY BRIEFING Transplant Immunology September 2017 The British Society of Immunology is the largest Introduction immunology society in Europe. Our mission is to promote excellence in immunological research, scholarship and Transplantation is the process of moving cells, tissues, or clinical practice in order to improve human and animal organs, from one site to another, either within the same health. We represent the interests of more than 3,000 person or between a donor and a recipient. If an organ immunologists working in academia, clinical medicine, system fails, or becomes damaged as a consequence of and industry. We have strong international links and disease or injury, it can be replaced with a healthy organ collaborate with our European, American and Asian or tissue from a donor. partner societies in order to achieve our aims. Organ transplantation is a major operation and is only Key points: offered when all other treatment options have failed. Consequently, it is often a life-saving intervention. In • Transplantation is the process of moving cells, 2015/16, 4,601 patient lives were saved or improved in i tissues or organs from one site to another for the the UK by an organ transplant. Kidney transplants are purpose of replacing or repairing damaged or the most common organ transplanted on the NHS in diseased organs and tissues. It saves thousands the UK (3,265 in 2015/16), followed by the liver (925), and i of lives each year. However, the immune system pancreas (230). In addition, a total of 383 combined heart poses a significant barrier to successful organ and lung transplants were performed, while in 2015/16.
    [Show full text]
  • PDI 07 Pediatric Heart Surgery Volume
    AHRQ QI, Pediatric Quality Indicators #7, Technical Specifications, Pediatric Heart Surgery Volume www.qualityindicators.ahrq.gov Pediatric Heart Surgery Volume Pediatric Quality Indicators #7 Technical Specifications Provider-Level Indicator AHRQ Quality Indicators, Version 4.4, March 2012 Numerator Discharges under age 18 with ICD-9-CM procedure codes for either congenital heart disease (1P) or non-specific heart surgery (2P) with ICD-9-CM diagnosis of congenital heart disease (2D) in any field. ICD-9-CM Congenital heart disease procedure codes (1P)1,2: 3500 CLOSED VALVOTOMY NOS 3551 PROS REP ATRIAL DEF-OPN 3501 CLOSED AORTIC VALVOTOMY 3552 PROS REPAIR ATRIA DEF-CL 3502 CLOSED MITRAL VALVOTOMY 3553 PROS REP VENTRIC DEF-OPN 3503 CLOSED PULMON VALVOTOMY 3554 PROS REP ENDOCAR CUSHION 3504 CLOSED TRICUSP VALVOTOMY 3560 GRFT REPAIR HRT SEPT NOS 3505 ENDOVAS REPL AORTC VALVE 3561 GRAFT REPAIR ATRIAL DEF 3506 TRNSAPCL REP AORTC VALVE 3562 GRAFT REPAIR VENTRIC DEF 3507 ENDOVAS REPL PULM VALVE 3563 GRFT REP ENDOCAR CUSHION 3508 TRNSAPCL REPL PULM VALVE 3570 HEART SEPTA REPAIR NOS 3510 OPEN VALVULOPLASTY NOS 3571 ATRIA SEPTA DEF REP NEC 3511 OPN AORTIC VALVULOPLASTY 3572 VENTR SEPTA DEF REP NEC 3512 OPN MITRAL VALVULOPLASTY 3573 ENDOCAR CUSHION REP NEC 3513 OPN PULMON VALVULOPLASTY 3581 TOT REPAIR TETRAL FALLOT 3514 OPN TRICUS VALVULOPLASTY 3582 TOTAL REPAIR OF TAPVC 3520 OPN/OTH REP HRT VLV NOS 3583 TOT REP TRUNCUS ARTERIOS 3521 OPN/OTH REP AORT VLV-TIS 3584 TOT COR TRANSPOS GRT VES 3522 OPN/OTH REP AORTIC VALVE 3591 INTERAT VEN RETRN TRANSP
    [Show full text]
  • 9. Types of Rejection Table of Contents 9.1 Antibody-Mediated Rejection
    9. Types of rejection Table of Contents 9.1 Antibody-mediated rejection 9.2 Chronic rejection 9.3 Hyperacute rejection 9.4 T-cell mediated rejection 9.5 Donor specific cell free DNA marker 9.1 Antibody-mediated rejection The 2019 Expert Consensus from the Transplantation Society Working Group (2020). Recommended Treatment for Antibody-mediated Rejection after Kidney Transplantation. Transplantation. 2020 Jan 8. doi: 10.1097/TP.0000000000003095. [Epub ahead of print]. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/31895348 • A consensus of expert opinion in regards to standard of care treatment for active and chronic active AMR after kidney transplantation Yamanashi K, Chen-Yoshikawa TF, Hamaji M, et al (2020). Outcomes of combination therapy including rituximab for antibody-mediated rejection after lung transplantation. Gen Thorac Cardiovasc Surg. 2020;68(2):142–149. doi:10.1007/s11748-019-01189-1. Retrieved from: https://europepmc.org/article/med/31435872 • This study is a retrospective analysis of a single center’s experience of using combination therapy (methylprednisolone, plasma exchange, and IVIG) including rituximab for post lung transplant AMR in Japanese patients. Spica D, Junker T, Dickenmann M, et al (2019). Daratumumab for Treatment of Antibody-Mediated Rejection after ABO-Incompatible Kidney Transplantation. Case Rep Nephrol Dial. 2019;9(3):149–157. Published 2019 Nov 13. doi:10.1159/000503951. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902247/ • A case report detailing the use of Daratnumumab for treatment of therapy-refractory AMR in the context of ABO-incompatible kidney transplantation. Kincaide E, Hitchman K, Hall R, Yamaguchi I, Ding Y, Crowther B (2019).
    [Show full text]
  • Newsletter Spring 2018
    A NEWSLETTER OF GIFT OF LIFE TRANSPLANT HOUSE SPRING/SUMMER 2018 DONATE LIFE MONTH GIFT OF LIFE Join us in recognition at the TRANSPLANT HOUSE following April events: A HOME THAT HELPS AND HEALS April 13 - Walk of Remembrance April 14 - Timmay 5k See our Facebook for details. AWAKENED BY THE GIFT OF LIFE sk Teresa Hoff what her favorite movie is and she will tell you empathicallyA it is Sleeping Beauty. Unlike the Disney movie, Teresa’s story is not a fairy tale and she wasn’t awakened by a prince. Teresa was awakened by a liver transplant! It all began at age 14. Teresa swam in a hometown lake which contained the e-coli bacteria. She spent the entire summer becoming increasingly ill and a visit to the doctor revealed a diagnosis of both Crohn’s disease and ulcerative colitis. The course of treatment was prednisone and while not Teresa, on right, four days pre-transplant with completely recovered, Teresa completed her her sister, Mary. high school career with honors. She entered the University of North Dakota, but grew While this was an intensely difficult time, it increasingly ill. She was referred to Mayo was also a happy time. Teresa met and Clinic at age 19 and was told her colon married her husband, Brad in May of 2005 would have to be removed. Teresa had the and began her 1st job. A bout of cholangitis procedure performed and, amazingly, landed her back at Mayo Clinic and in June returned to college, graduating in 2005 2008, Teresa received her 1st life-saving liver with a degree in Physical Therapy.
    [Show full text]
  • Partnering with Your Transplant Team the Patient’S Guide to Transplantation
    Partnering With Your Transplant Team The Patient’s Guide to Transplantation U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration This booklet was prepared for the Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation by the United Network for Organ Sharing (UNOS). PARTNERING WITH YOUR TRANSPLANT TEAM THE PATIENT’S GUIDE TO TRANSPLANTATION U.S. Department of Health and Human Services Health Resources and Services Administration Public Domain Notice All material appearing in this document, with the exception of AHA’s The Patient Care Partnership: Understanding Expectations, Rights and Responsibilities, is in the public domain and may be reproduced without permission from HRSA. Citation of the source is appreciated. Recommended Citation U.S. Department of Health and Human Services (2008). Partnering With Your Transplant Team: The Patient’s Guide to Transplantation. Rockville, MD: Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation. DEDICATION This book is dedicated to organ donors and their families. Their decision to donate has given hundreds of thousands of patients a second chance at life. CONTENTS Page INTRODUCTION.........................................................................................................................1 THE TRANSPLANT EXPERIENCE .........................................................................................3 The Transplant Team .......................................................................................................................4
    [Show full text]
  • Gregory J. “Jerry” Jurkovich, MD President 2008–2009
    37 Gregory J. “Jerry” Jurkovich, MD President 2008–2009 Dr. David H. Livingston The classic and most obvious question is about your choice of career in trauma, critical care and now acute care surgery. How did you get there? At what point in your training did you decide? Dr. Gregory J. “Jerry” Jurkovich During elementary and middle school I definitely thought I was going to be an astronaut. That was the time when the Mercury program and Apollo moon shots were capturing the imagi- nation of the nation, and people were influenced by their success. People were talking about what just seemed to be the future direction of the world. I was attracted to that and since I was naturally good at the math and sciences I thought I was on the way. But then I ran into one of those big disappointments in life: you had to be a perfect human specimen in terms of vision and physical stature. At that time you also had to become a pilot first, and join the military. The harsh reality of all of those issues made it obvious that this not going to work out very well. So I went to college to study math and sciences. I was going to be an engineer. I still hadn’t completely given up on the whole astronaut thing and thought maybe a way through NASA was on the engineering side. I did mix it with medicine and got a degree in biomedical engineering. By the end of the degree I realized I enjoyed and wanted more people contact than I was getting in engineering so I decided to go to medical school.
    [Show full text]
  • Organ Transplant Discrimination Against People with Disabilities Part of the Bioethics and Disability Series
    Organ Transplant Discrimination Against People with Disabilities Part of the Bioethics and Disability Series National Council on Disability September 25, 2019 National Council on Disability (NCD) 1331 F Street NW, Suite 850 Washington, DC 20004 Organ Transplant Discrimination Against People with Disabilities: Part of the Bioethics and Disability Series National Council on Disability, September 25, 2019 This report is also available in alternative formats. Please visit the National Council on Disability (NCD) website (www.ncd.gov) or contact NCD to request an alternative format using the following information: [email protected] Email 202-272-2004 Voice 202-272-2022 Fax The views contained in this report do not necessarily represent those of the Administration, as this and all NCD documents are not subject to the A-19 Executive Branch review process. National Council on Disability An independent federal agency making recommendations to the President and Congress to enhance the quality of life for all Americans with disabilities and their families. Letter of Transmittal September 25, 2019 The President The White House Washington, DC 20500 Dear Mr. President, On behalf of the National Council on Disability (NCD), I am pleased to submit Organ Transplants and Discrimination Against People with Disabilities, part of a five-report series on the intersection of disability and bioethics. This report, and the others in the series, focuses on how the historical and continued devaluation of the lives of people with disabilities by the medical community, legislators, researchers, and even health economists, perpetuates unequal access to medical care, including life- saving care. Organ transplants save lives. But for far too long, people with disabilities have been denied organ transplants as a result of unfounded assumptions about their quality of life and misconceptions about their ability to comply with post-operative care.
    [Show full text]
  • Thickness After Heart Transplantation Acute Cellular Rejection and Left
    Downloaded from heart.bmj.com on 19 November 2006 Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation H A de Groot-Kruseman, C C Baan, E M Hagman, W M Mol, H G Niesters, A P Maat, P E Zondervan, W Weimar and A H Balk Heart 2002;87;363-367 doi:10.1136/heart.87.4.363 Updated information and services can be found at: http://heart.bmj.com/cgi/content/full/87/4/363 These include: References This article cites 27 articles, 5 of which can be accessed free at: http://heart.bmj.com/cgi/content/full/87/4/363#BIBL 1 online articles that cite this article can be accessed at: http://heart.bmj.com/cgi/content/full/87/4/363#otherarticles Rapid responses You can respond to this article at: http://heart.bmj.com/cgi/eletter-submit/87/4/363 Email alerting Receive free email alerts when new articles cite this article - sign up in the box at the service top right corner of the article Topic collections Articles on similar topics can be found in the following collections Other Cardiovascular Medicine (2051 articles) Transplantation (283 articles) Molecular Medicine (1113 articles) Other immunology (943 articles) Notes To order reprints of this article go to: http://www.bmjjournals.com/cgi/reprintform To subscribe to Heart go to: http://www.bmjjournals.com/subscriptions/ Downloaded from heart.bmj.com on 19 November 2006 363 BASIC RESEARCH Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation H A de Groot-Kruseman, C C Baan, E M Hagman, W M Mol, H G Niesters, A P Maat, P E Zondervan, W Weimar, A H Balk ............................................................................................................................
    [Show full text]
  • Chronic Rejection Autoimmunity
    Antibodies to MHC Class I Induce Autoimmunity: Role in the Pathogenesis of Chronic Rejection This information is current as Naohiko Fukami, Sabarinathan Ramachandran, Deepti Saini, of September 26, 2021. Michael Walter, William Chapman, G. Alexander Patterson and Thalachallour Mohanakumar J Immunol 2009; 182:309-318; ; doi: 10.4049/jimmunol.182.1.309 http://www.jimmunol.org/content/182/1/309 Downloaded from References This article cites 54 articles, 10 of which you can access for free at: http://www.jimmunol.org/content/182/1/309.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 26, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2009 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Antibodies to MHC Class I Induce Autoimmunity: Role in the Pathogenesis of Chronic Rejection1 Naohiko Fukami,* Sabarinathan Ramachandran,* Deepti Saini,* Michael Walter,‡ William Chapman,* G. Alexander Patterson,§ and Thalachallour Mohanakumar2*† Alloimmunity to mismatched donor HLA-Ags and autoimmunity to self-Ags have been hypothesized to play an important role in immunopathogenesis of chronic rejection of transplanted organs.
    [Show full text]