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The Evidence for Acute Internal Medicine and Acute Medical Units

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The Evidence for Acute Internal Medicine and Acute Medical Units Future Hospital Journal 2016 Vol 3, No 1: 45–8 GENERALISM SPECIAL T h e e v i d e n c e f o r a c u t e i n t e r n a l m e d i c i n e a n d a c u t e medical units A Author: M i k e J o n e s Acute medicine and acute medical units are relatively new recognised as a separate specialty with defined training 10 innovations. The evolving evidence base is demonstrating programmes. This organisation and specialisation means the effectiveness of these in improving care given to patients that the large majority of physician trainees now receive much with acute medical illness. This article reviews the available of their training in the care of acutely unwell medical patients evidence. while working in the AMU environment. ABSTRACT The key features and objectives of AIM are: KEYWORDS : Acute medicine , acute medical units > clinical service delivered by consultant physicians within the AMU environs for at least 12 hours per day and seven days per week Introduction > medical leadership within an AMU in a service designed and Acute medical units (AMUs) have been defined by the Royal managed by consultant physicians who specialise in AIM College of Physicians (RCP) as ‘a dedicated facility within a > service delivered by an AIM specialist and dedicated hospital that acts as the focus for acute medical care for patients multidisciplinary team with timely and appropriate who have presented as medical emergencies to hospital’.1 I n t h e interaction with other specialties past decade AMUs, as a base for the practise of acute internal > service design informed by quality standards medicine (AIM), have become integral to the care pathway of > performance benchmarked against key clinical quality most patients who require hospital-based acute medical care in indicators for AMU. 2,3 the UK. Other countries are increasingly adopting this model While surveys of care delivered within AMUs in the UK have 4 5,6 of care, including Ireland, Australasia and other parts of consistently reported heterogeneity with regard to organisation, 7–9 Europe. services and staffing, 11–15 specific recommendations suggest AMUs first emerged in the 1990s often as a result of the local that medical care provided for patients in the AMU should service recognising the need to improve acute medical care. include the following. 1 However, there was limited evidence of the effectiveness of this model of care at that time. This review will discuss some of the 1. Patient assessment both in an ambulatory emergency care evidence which supports the acute medical model of care for setting and as part of a possible admission process patients admitted on the medical take. 2. Treatment – first-line treatments are often commenced within the short stay area (48–72 hours) of the AMU. 3. Further care planning – decisions about further Acute medical unit standards of care investigations and specialty referrals are made. Discharge In the early 1990s it was recognised that the established model planning should commence at the time of admission or of medical patients being admitted from the emergency a specialty bed requested. Effective multiprofessional department (ED) directly to a ward bed was unsustainable teamworking is integral to optimal AMU functioning. in the face of reduced bed capacity and increasing patient Where required, complex ethical decisions are usually made attendances/admissions. Alternative models of care were in the AMU, such as cardiopulmonary resuscitation status required. AIM evolved to provide patients with acute medical or deprivation of liberty orders. illness with the best quality care, in the right environment, 4. Practical procedures – a number of investigative and with assessment, diagnosis and treatment as actively managed therapeutic procedures are provided in an AMU. components of that care. Investigations such as lumbar puncture should be available The specialty of AIM was first introduced as a branch of in every AMU. The provision for other procedures is general internal medicine (GIM) but by 2009 was legally variable, such as echocardiography and ultrasound. 5. Delivery of high profile quality initiatives – there are a number of conditions where poor care is recognised in contributing to adverse patient outcomes. The highest Author: A consultant acute physician, Acute Medicine, University profile examples are sepsis and acute kidney injury. Hospital of North Durham, Durham, UK Both are seen frequently in AMUs and initiatives have © Royal College of Physicians 2016. All rights reserved. 45 FHJv3n1-Jones.indd 45 20/01/16 12:05 PM Mike Jones been undertaken to improve the care delivered for these transfers from an AMU following admission may introduce conditions. further delay. 6. Higher level care – an AMU does not provide high- dependency care but in some AMUs enhanced levels of care, M o r t a l i t y such as non-invasive ventilation or increased monitoring, may be provided. Mortality data presented in several studies were assessed at 7. Generic care – AMU is frequently the starting point for a variety of time points: in-hospital, 30-day post admission, 7,16–19,23,24,26,27 the care described in local commissioning for quality and 30-day post discharge and annual. I n m a n y o f innovation payments, eg assessment for and provision of the studies, patient admission to the AMU was associated VTE prophylaxis. with reduced mortality by comparison with patients 8. Access to diagnostic services – every AMU must be admitted under non-AMU models of care. By contrast, one supported by a full range of diagnostic investigations. study has reported non-significant increases in 30-day and 9. Access to higher level care – every AMU must be supported in-hospital mortality in those receiving AMU care. It is by a critical care unit and coronary care unit. notable however that in this study baseline mortality rates 7 10. Specialty in-reach – given the variety of patient were higher than those in comparable studies. In these nine presentations medical specialty in-reach or co-location studies the absolute change in mortality between the AMU from cardiology, medicine for care of the elderly and and non-AMU groups ranged from +1.3% to –8.8%. Four respiratory medicine is an absolute requirement. Ready studies attempted to adjust for confounding factors. The first availability of advice and specialty management pathways demonstrated that while not all patients could be allocated from the other medical specialties is critical. As well as to the AMU due to capacity constraints, the univariate medical specialities, AIM needs to work closely with other odds ratio of an in-hospital death by day 30 for a patient disciplines, for example surgical specialities, obstetrics and initially allocated to the AMU, compared with an initial gynaecology, intensive care medicine and psychiatry. ward allocation was 0.76 (95% CI 0.71, 0.82; p<0.001). The fully adjusted risk for patients was 0.67 (95% CI 0.62, 0.73; p<0.001). 16 A second study using propensity score matching The evidence for AMU care demonstrated a non-significant reduction in in-hospital Over the past decade, evidence has increasingly demonstrated mortality in the AMU cohort compared with the non-AMU the benefit of AMU models of care. Initial research has focused cohort (unmatched analysis 3.7 vs 4.6%; matched analysis 4.2 on the following outcomes as important quality indicators: vs 4.6%). 17 Investigators undertaking a third study adjusted mortality, hospital length of stay (LOS), hospital readmission for time based changes in mortality in the population. In and patient/staff satisfaction. These will be discussed in more addition to an overall trend towards reduced mortality detail here. implementation of specialty triage was associated with a significant reduction in the subsequent mortality of the under Hospital length of stay 65 age group by a further 0.64% (95% CI 0.11, 1.17%; p = 0.021), equivalent to approximately 51 fewer deaths per year. Hospital LOS represents a composite measure which not There was, however, no significant effect of specialty triage for only indicates effectiveness of clinical treatment but also those aged over 65 or all age groups combined.18 A final study the efficiency of processes of care. Hospital LOS has been used logistic regression to adjust for confounding factors 7,8,16–26 assessed in many recent studies. The majority of including comorbidities, illness severity score and disease studies demonstrated a statistically significant difference in category. A significant reduction in in-hospital mortality in favour of AMU care. In the studies that reported the mean the AMU group by comparison with the non-AMU group was LOS for the two groups, the reduction ranged from 0.3 reported (adjusted odds ratio 0.28; 95% CI 0.23, 0.35).27 I n to 2.62 days. However, only three of these attempted to adjust general, these studies suggest that the admission of patients to for confounding factors. AMU in acute medical illness decreases overall mortality. In the first, which used propensity score matching, the mean reduction in LOS was 0.8 days in the matched analysis versus Hospital readmission 0.11 days in the unmatched. Both studies showed a statistically significant reduction in length of stay.17 A second study in Hospital readmissions following discharge are rightly which adjustment was made for secular trends, demonstrated considered an adverse outcome. While a failure of social and that the LOS was 0.73 days less in the AMU group when other community care may contribute to readmissions rates, compared to the non-AMU group (95% confidence interval such events are nevertheless regarded as markers of suboptimal (CI) –1.5, 0.04; p = 0.067).
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