MUSE) at PSI and the Proton Radius Puzzle
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Charged-Particle (Proton Or Helium Ion) Radiotherapy for Neoplastic Conditions
Charged-Particle (Proton or Helium Ion) Radiotherapy for Neoplastic Conditions Policy Number: Original Effective Date: MM.05.005 07/01/2009 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration 07/28/2017 Section: Radiology Place(s) of Service: Outpatient I. Description Charged-particle beams consisting of protons or helium ions are a type of particulate radiation therapy (RT). Treatment with charged-particle radiotherapy is proposed for a large number of indications, often for tumors that would benefit from the delivery of a high dose of radiation with limited scatter that is enabled by charged-particle beam radiotherapy. For individuals who have uveal melanoma(s) who receive charged-particle (proton or helium ion) radiotherapy, the evidence includes RCTs and systematic reviews. Relevant outcomes are overall survival, disease-free survival, change in disease status, and treatment-related morbidity. Systematic reviews, including a 1996 TEC Assessment and a 2013 review of randomized and non- randomized studies, concluded that the technology is at least as effective as alternative therapies for treating uveal melanomas and is better at preserving vision. The evidence is sufficient to determine qualitatively that the technology results in a meaningful improvement in the net health outcome. For individuals who have skull-based tumor(s) (i.e., cervical chordoma and chondrosarcoma) who receive charged-particle (proton or helium ion) radiotherapy, the evidence includes observational studies and systematic reviews. Relevant outcomes are overall survival, disease-free survival, change in disease status, and treatment-related morbidity. A 1996 TEC Assessment concluded that the technology is at least as effective as alternative therapies for treating skull-based tumors. -
Charge Radius of the Short-Lived Ni68 and Correlation with The
PHYSICAL REVIEW LETTERS 124, 132502 (2020) Charge Radius of the Short-Lived 68Ni and Correlation with the Dipole Polarizability † S. Kaufmann,1 J. Simonis,2 S. Bacca,2,3 J. Billowes,4 M. L. Bissell,4 K. Blaum ,5 B. Cheal,6 R. F. Garcia Ruiz,4,7, W. Gins,8 C. Gorges,1 G. Hagen,9 H. Heylen,5,7 A. Kanellakopoulos ,8 S. Malbrunot-Ettenauer,7 M. Miorelli,10 R. Neugart,5,11 ‡ G. Neyens ,7,8 W. Nörtershäuser ,1,* R. Sánchez ,12 S. Sailer,13 A. Schwenk,1,5,14 T. Ratajczyk,1 L. V. Rodríguez,15, L. Wehner,16 C. Wraith,6 L. Xie,4 Z. Y. Xu,8 X. F. Yang,8,17 and D. T. Yordanov15 1Institut für Kernphysik, Technische Universität Darmstadt, D-64289 Darmstadt, Germany 2Institut für Kernphysik and PRISMA+ Cluster of Excellence, Johannes Gutenberg-Universität Mainz, D-55128 Mainz, Germany 3Helmholtz Institute Mainz, GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt, Germany 4School of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, United Kingdom 5Max-Planck-Institut für Kernphysik, D-69117 Heidelberg, Germany 6Oliver Lodge Laboratory, Oxford Street, University of Liverpool, Liverpool L69 7ZE, United Kingdom 7Experimental Physics Department, CERN, CH-1211 Geneva 23, Switzerland 8KU Leuven, Instituut voor Kern- en Stralingsfysica, B-3001 Leuven, Belgium 9Physics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA and Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996, USA 10TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, V6T 2A3, Canada 11Institut -
Muonic Atoms and Radii of the Lightest Nuclei
Muonic atoms and radii of the lightest nuclei Randolf Pohl Uni Mainz MPQ Garching Tihany 10 June 2019 Outline ● Muonic hydrogen, deuterium and the Proton Radius Puzzle New results from H spectroscopy, e-p scattering ● Muonic helium-3 and -4 Charge radii and the isotope shift ● Muonic present: HFS in μH, μ3He 10x better (magnetic) Zemach radii ● Muonic future: muonic Li, Be 10-100x better charge radii ● Ongoing: Triton charge radius from atomic T(1S-2S) 400fold improved triton charge radius Nuclear rms charge radii from measurements with electrons values in fm * elastic electron scattering * H/D: laser spectroscopy and QED (a lot!) * He, Li, …. isotope shift for charge radius differences * for medium-high Z (C and above): muonic x-ray spectroscopy sources: * p,d: CODATA-2014 * t: Amroun et al. (Saclay) , NPA 579, 596 (1994) * 3,4He: Sick, J.Phys.Chem.Ref Data 44, 031213 (2015) * Angeli, At. Data Nucl. Data Tab. 99, 69 (2013) The “Proton Radius Puzzle” Measuring Rp using electrons: 0.88 fm ( +- 0.7%) using muons: 0.84 fm ( +- 0.05%) 0.84 fm 0.88 fm 5 μd 2016 CODATA-2014 4 μp 2013 5.6 σ 3 e-p scatt. μp 2010 2 H spectroscopy 1 0.83 0.84 0.85 0.86 0.87 0.88 0.89 0.9 Proton charge radius R [fm] ch μd 2016: RP et al (CREMA Coll.) Science 353, 669 (2016) μp 2013: A. Antognini, RP et al (CREMA Coll.) Science 339, 417 (2013) The “Proton Radius Puzzle” Measuring Rp using electrons: 0.88 fm ( +- 0.7%) using muons: 0.84 fm ( +- 0.05%) 0.84 fm 0.88 fm 5 μd 2016 CODATA-2014 4 μp 2013 5.6 σ 3 e-p scatt. -
Plasma Heating by Intense Charged Particle-Beams Injected on Solid Targets T
PLASMA HEATING BY INTENSE CHARGED PARTICLE-BEAMS INJECTED ON SOLID TARGETS T. Okada, T. Shimojo, K. Niu To cite this version: T. Okada, T. Shimojo, K. Niu. PLASMA HEATING BY INTENSE CHARGED PARTICLE-BEAMS INJECTED ON SOLID TARGETS. Journal de Physique Colloques, 1988, 49 (C7), pp.C7-185-C7-189. 10.1051/jphyscol:1988721. jpa-00228205 HAL Id: jpa-00228205 https://hal.archives-ouvertes.fr/jpa-00228205 Submitted on 1 Jan 1988 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. JOURNAL DE PHYSIQUE Colloque C7, supplgment au n012, Tome 49, dbcembre 1988 PLASMA HEATING BY INTENSE CHARGED PARTICLE-BEAMS INJECTED ON SOLID TARGETS T. OKADA, T. SHIMOJO* and K. NIU* ' Department of Applied Physics, Tokyo University of Agriculture and Technology, Koganei-shi, Tokyo 184, Japan *~epartmentof Physics, Tokyo Gakugei University, Koganei-shi, Tokyo 184, Japan Department of Energy Sciences, Tokyo Institute of Technology, Midori-ku, Yokohama 227, Japan Rbsunb - La production et le chauffage du plasma sont estimbs numbriquement B l'aide d'un modele simple pour l'interaction de faisceaux intenses d'blectrons ou protons avec plusieurs cibles solides. On obtient ainsi les longueurs d'ionisation et la temperature du plasma produit. -
The MITP Proton Radius Puzzle Workshop
Report on The MITP Proton Radius Puzzle Workshop June 2–6, 2014 in Waldthausen Castle, Mainz, Germany 1 Description of the Workshop The organizers of the workshop were: • Carl Carlson, William & Mary, [email protected] • Richard Hill, University of Chicago, [email protected] • Savely Karshenboim, MPI fur¨ Quantenoptik & Pulkovo Observatory, [email protected] • Marc Vanderhaeghen, Universitat¨ Mainz, [email protected] The web page of the workshop, which contains all talks, can be found at https://indico.mitp.uni-mainz.de/conferenceDisplay.py?confId=14 . The size of the proton is one of the most fundamental observables in hadron physics. It is measured through an electromagnetic form factor. The latter is directly related to the distribution of charge and magnetization of the baryon and through such imaging provides the basis of nearly all studies of the hadron structure. In very recent years, a very precise knowledge of nucleon form factors has become more and more im- portant as input for precision experiments in several fields of physics. Well known examples are the hydrogen Lamb shift and the hydrogen hyperfine splitting. The atomic physics measurements of energy level splittings reach an impressive accuracy of up to 13 significant digits. Its theoretical understanding however is far less accurate, being at the part-per-million level (ppm). The main theoretical uncertainty lies in proton structure corrections, which limits the search for new physics in these kinds of experiment. In this context, the recent PSI measurement of the proton charge radius from the Lamb shift in muonic hydrogen has given a value that is a startling 4%, or 5 standard deviations, lower than the values ob- tained from energy level shifts in electronic hydrogen and from electron-proton scattering experiments, see figure below. -
Production of Radioactive Isotopes: Cyclotrons and Accelerators Numbers of Accelerators Worldwide: Type and Application
Isotopes: production and application Kornoukhov Vasily Nikolaevich [email protected] Lecture No 5 Production of radioactive isotopes: cyclotrons and accelerators Numbers of accelerators worldwide: type and application TOTAL TOTAL ~ 42 400 ~ 42 400 Electron Protons and ions Science Industry Accelerators Accelerators ~ 1 200 ~ 27 000 27 000 12 000 Medicine Protons ~ 14 200 Accelerators Ion implantation in 4 000 microelectronics ~ 1.5 B$/year Cost of food after sterilization ~ 500 B$/year 20.11.2020 Lecture No 5: Production of radioactive isotopes: cyclotrons and accelerators V.N. Kornoukhov 2 Accelerators for radionuclide production Characterization of accelerators for radionuclide production General cross-sectional behavior for nuclear reactions as a function of the The number of charged particles is usually measured as an electric current incident particle energy. Since the proton has to overcome the Coulomb in microamperes (1 μA = 6 × 1012 protons/s = 3 × 1012 alpha/s) barrier, there is a threshold that is not present for the neutron. Even very low energy neutrons can penetrate into the nucleus to cause a nuclear reaction. In the classic sense, a reaction between a charged particle and a nucleus cannot take place if the center of mass energy of the two particles is less than the Coulomb barrier. It implies that the charged particle must have an energy greater than the electrostatic repulsion, which is given by the following B = Zˑzˑe2/R where B is the barrier to the reaction; Z and z are the atomic numbers of the two species; R is the separation of the two species (cm). 20.11.2020 Lecture No 5: Production of radioactive isotopes: cyclotrons and accelerators V.N. -
Protocol for Heavy Charged-Particle Therapy Beam Dosimetry
AAPM REPORT NO. 16 PROTOCOL FOR HEAVY CHARGED-PARTICLE THERAPY BEAM DOSIMETRY Published by the American Institute of Physics for the American Association of Physicists in Medicine AAPM REPORT NO. 16 PROTOCOL FOR HEAVY CHARGED-PARTICLE THERAPY BEAM DOSIMETRY A REPORT OF TASK GROUP 20 RADIATION THERAPY COMMITTEE AMERICAN ASSOCIATION OF PHYSICISTS IN MEDICINE John T. Lyman, Lawrence Berkeley Laboratory, Chairman Miguel Awschalom, Fermi National Accelerator Laboratory Peter Berardo, Lockheed Software Technology Center, Austin TX Hans Bicchsel, 1211 22nd Avenue E., Capitol Hill, Seattle WA George T. Y. Chen, University of Chicago/Michael Reese Hospital John Dicello, Clarkson University Peter Fessenden, Stanford University Michael Goitein, Massachusetts General Hospital Gabrial Lam, TRlUMF, Vancouver, British Columbia Joseph C. McDonald, Battelle Northwest Laboratories Alfred Ft. Smith, University of Pennsylvania Randall Ten Haken, University of Michigan Hospital Lynn Verhey, Massachusetts General Hospital Sandra Zink, National Cancer Institute April 1986 Published for the American Association of Physicists in Medicine by the American Institute of Physics Further copies of this report may be obtained from Executive Secretary American Association of Physicists in Medicine 335 E. 45 Street New York. NY 10017 Library of Congress Catalog Card Number: 86-71345 International Standard Book Number: 0-88318-500-8 International Standard Serial Number: 0271-7344 Copyright © 1986 by the American Association of Physicists in Medicine All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise) without the prior written permission of the publisher. Published by the American Institute of Physics, Inc., 335 East 45 Street, New York, New York 10017 Printed in the United States of America Contents 1 Introduction 1 2 Heavy Charged-Particle Beams 3 2.1 ParticleTypes ......................... -
Physics Has a Core Problem
Physics Has a Core Problem Physicists can solve many puzzles by taking more accurate and careful measurements. Randolf Pohl and his colleagues at the Max Planck Institute of Quantum Optics in Garching, however, actually created a new problem with their precise measurements of the proton radius, because the value they measured differs significantly from the value previously considered to be valid. The difference could point to gaps in physicists’ picture of matter. Measuring with a light ruler: Randolf Pohl and his team used laser spectroscopy to determine the proton radius – and got a surprising result. PHYSICS & ASTRONOMY_Proton Radius TEXT PETER HERGERSBERG he atmosphere at the scien- tific conferences that Ran- dolf Pohl has attended in the past three years has been very lively. And the T physicist from the Max Planck Institute of Quantum Optics is a good part of the reason for this liveliness: the commu- nity of experts that gathers there is working together to solve a puzzle that Pohl and his team created with its mea- surements of the proton radius. Time and time again, speakers present possible solutions and substantiate them with mathematically formulated arguments. In the process, they some- times also cast doubt on theories that for decades have been considered veri- fied. Other speakers try to find weak spots in their fellow scientists’ explana- tions, and present their own calcula- tions to refute others’ hypotheses. In the end, everyone goes back to their desks and their labs to come up with subtle new deliberations to fuel the de- bate at the next meeting. In 2010, the Garching-based physi- cists, in collaboration with an interna- tional team, published a new value for the charge radius of the proton – that is, the nucleus at the core of a hydro- gen atom. -
Arxiv:2005.08389V1 [Physics.Acc-Ph] 17 May 2020
Proceedings of the 2018 CERN–Accelerator–School course on Beam Instrumentation, Tuusula, (Finland) Beam Diagnostic Requirements: an Overview G. Kube Deutsches Elektronen Synchrotron (DESY), Hamburg, Germany Abstract Beam diagnostics and instrumentation are an essential part of any kind of ac- celerator. There is a large variety of parameters to be measured for observation of particle beams with the precision required to tune, operate, and improve the machine. In the first part, the basic mechanisms of information transfer from the beam particles to the detector are described in order to derive suitable per- formance characteristics for the beam properties. However, depending on the type of accelerator, for the same parameter, the working principle of a monitor may strongly differ, and related to it also the requirements for accuracy. There- fore, in the second part, selected types of accelerators are described in order to illustrate specific diagnostics needs which must be taken into account before designing a related instrument. Keywords Particle field; beam signal; electron/hadron accelerator; instrumentation. 1 Introduction Nowadays particle accelerators play an important role in a wide number of fields, the number of acceler- ators worldwide is of the order of 30000 and constantly growing. While most of these devices are used for industrial and medical applications (ion implantation, electron beam material processing and irradia- tion, non-destructive inspection, radiotherapy, medical isotopes production, :::), the share of accelerators used for basic science is less than 1 % [1]. In order to cover such a wide range of applications different accelerator types are required. As an example, in the arts, the Louvre museum utilizes a 2 MV tandem Pelletron accelerator for ion beam anal- ysis studies [2]. -
Electron Charge Density: a Clue from Quantum Chemistry for Quantum Foundations
Electron Charge Density: A Clue from Quantum Chemistry for Quantum Foundations Charles T. Sebens California Institute of Technology arXiv v.2 June 24, 2021 Forthcoming in Foundations of Physics Abstract Within quantum chemistry, the electron clouds that surround nuclei in atoms and molecules are sometimes treated as clouds of probability and sometimes as clouds of charge. These two roles, tracing back to Schr¨odingerand Born, are in tension with one another but are not incompatible. Schr¨odinger'sidea that the nucleus of an atom is surrounded by a spread-out electron charge density is supported by a variety of evidence from quantum chemistry, including two methods that are used to determine atomic and molecular structure: the Hartree-Fock method and density functional theory. Taking this evidence as a clue to the foundations of quantum physics, Schr¨odinger'selectron charge density can be incorporated into many different interpretations of quantum mechanics (and extensions of such interpretations to quantum field theory). Contents 1 Introduction2 2 Probability Density and Charge Density3 3 Charge Density in Quantum Chemistry9 3.1 The Hartree-Fock Method . 10 arXiv:2105.11988v2 [quant-ph] 24 Jun 2021 3.2 Density Functional Theory . 20 3.3 Further Evidence . 25 4 Charge Density in Quantum Foundations 26 4.1 GRW Theory . 26 4.2 The Many-Worlds Interpretation . 29 4.3 Bohmian Mechanics and Other Particle Interpretations . 31 4.4 Quantum Field Theory . 33 5 Conclusion 35 1 1 Introduction Despite the massive progress that has been made in physics, the composition of the atom remains unsettled. J. J. Thomson [1] famously advocated a \plum pudding" model where electrons are seen as tiny negative charges inside a sphere of uniformly distributed positive charge (like the raisins|once called \plums"|suspended in a plum pudding). -
The OPAL Framework (Object Oriented Parallel Accelerator Library) Version 1.1.9 User's Reference Manual
PSI-PR-08-02 The OPAL Framework (Object Oriented Parallel Accelerator Library) Version 1.1.91 User’s Reference Manual Andreas Adelmann, Achim Gsell, Christof Kraus (PSI) Yves Ineichen (IBM), Steve Russell (LANL), Yuanjie Bi, Chuan Wang, Jianjun Yang (CIAE), Hao Zha (Thinghua University) Suzanne Sheehy, Chris Rogers (RAL) and Christopher Mayes (Cornell) Abstract OPAL is a tool for charged-particle optics in accelerator structures and beam lines. Using the MAD language with extensions, OPAL is derived from MAD9P and is based on the CLASSIC class library, which was started in 1995 by an international collaboration. IPPL (Independent Parallel Par- ticle Layer) is the framework which provides parallel particles and fields using data parallel ansatz. OPAL is built from the ground up as a parallel application exemplifying the fact that HPC (High Performance Computing) is the third leg of science, complementing theory and the experiment. HPC is made possible now through the increasingly sophisticated mathematical models and evolving com- puter power available on the desktop and in super computer centres. OPAL runs on your laptop as well as on the largest HPC clusters available today. The OPAL framework makes it easy to add new features in the form of new C++ classes. It comes in the following flavours: OPAL-CYCL tracks particles with 3D space charge including neighbouring turns in cyclotrons with time as the independent variable. OPAL-T is a superset of IMPACT-T [40] and can be used to model guns, injectors and complete XFEL’s excluding the undulator. It should be noted that not all features of OPAL are available in all flavours. -
S Ince the Brilliant Insights and Pioneering
The secret life of quarks ince the brilliant insights and pioneering experiments of Geiger, S Marsden and Rutherford first revealed that atoms contain nuclei [1], nuclear physics has developed into an astoundingly rich and diverse field. We have probed the complexities of protons and nuclei in our laboratories; we have seen how nuclear processes writ large in the cosmos are key to our existence; and we have found a myriad of ways to harness the nuclear realm for energy, medical and security applications. Nevertheless, many open questions still remain in nuclear physics— the mysterious and hidden world that is the domain of quarks and gluons. 44 ) detmold mit physics annual 2017 The secret life by William of quarks Detmold The modern picture of an atom includes multiple layers of structure: atoms are composed of nuclei and electrons; nuclei are composed of protons and neutrons; and protons and neutrons are themselves composed of quarks—matter particles—that are held together by force- carrying particles called gluons. And it is the primary goal of the Large Hadron Collider (LHC) in Geneva, Switzerland, to investigate the tantalizing possibility that an even deeper structure exists. Despite this understanding, we are only just beginning to be able to predict the properties and interactions of nuclei from the underlying physics of quarks and gluons, as these fundamental constituents are never seen directly in experiments but always remain confined inside composite particles (hadrons), such as the proton. Recent progress in supercomputing and algorithm development has changed this, and we are rapidly approaching the point where precision calculations of the simplest nuclear processes will be possible.