Onsite Program | 1 Welcome to the 2019 SBI/ACR Breast Imaging Symposium
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Features of MRI Stromal Enhancement with Neoadjuvant Chemotherapy: a Subgroup Analysis of the ACRIN 6657/I-SPY TRIAL
Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL Adam Olshen Denise Wolf Ella F. Jones David Newitt Laura van ‘t Veer Christina Yau Laura Esserman Julia D. Wulfkuhle Rosa I. Gallagher Lisa Singer Emanuel F. Petricoin, III Nola Hylton Catherine C. Park Adam Olshen, Denise Wolf, Ella F. Jones, David Newitt, Laura van ‘t Veer, Christina Yau, Laura Esserman, Julia D. Wulfkuhle, Rosa I. Gallagher, Lisa Singer, Emanuel F. Petricoin, , IIINola Hylton, Catherine C. Park, “Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL,” J. Med. Imag. 5(1), 011014 (2017), doi: 10.1117/1.JMI.5.1.011014. Downloaded From: https://www.spiedigitallibrary.org/journals/Journal-of-Medical-Imaging on 3/15/2018 Terms of Use: https://www.spiedigitallibrary.org/terms-of-use Journal of Medical Imaging 5(1), 011014 (Jan–Mar 2018) Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL Adam Olshen,a,b Denise Wolf,c Ella F. Jones,d David Newitt,e Laura van ‘t Veer,c Christina Yau,e Laura Esserman,e Julia D. Wulfkuhle,f Rosa I. Gallagher,f Lisa Singer,g Emanuel F. Petricoin III,f Nola Hylton,d and Catherine C. Parkb,g,* aUniversity of California San Francisco, Department of Biostatistics and Epidemiology, San Francisco, California, United States bUniversity of California San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States cUniversity -
PROTOCOL—CONTACT Phone: (401) 863-9183 ACRIN PROTOCOL DEVELOPMENT Fax: (401) 863-9182 and REGULATORY COMPLIANCE [email protected] for a COMPLETE PROTOCOL
AMERICAN COLLEGE OF RADIOLOGY IMAGING NETWORK ACRIN 6657 CONTRAST-ENHANCED BREAST MRI and MRS FOR EVALUATION OF PATIENTS UNDERGOING NEOADJUVANT TREATMENT FOR LOCALLY ADVANCED BREAST CANCER ACRIN Principal Investigator InterSPORE Principal Investigator Nola M. Hylton, PhD Laura J. Esserman, MD, MBA University of California, San Francisco UCSF Mt. Zion MRSC, Box 1290 Carol Franc Buck Breast Ctr. One Irving St., Room AC-109 2356 Sutter St., 6th Floor San Francisco, CA 94143-1290 San Francisco, CA 94115 Phone: (415) 476-8856 Phone: (415) 885-7691 Fax: (415) 475-8809 Fax: (415) 353-9571 [email protected] [email protected] Statistician Constantine Gatsonis, PhD Center for Statistical Sciences Brown University, Box G-S121-7 121 South Main Street, 7th Floor Providence, RI 02912 PARTIAL PROTOCOL—CONTACT Phone: (401) 863-9183 ACRIN PROTOCOL DEVELOPMENT Fax: (401) 863-9182 AND REGULATORY COMPLIANCE [email protected] FOR A COMPLETE PROTOCOL Radiology Co-Investigators and Institutions Etta Pisano, MD Paul Weatherall, MD University of North Carolina-Chapel Hill University of Texas, Southwestern Mitchell Schnall, MD, PhD, Mark Rosen, MD, PhD Constance Lehman, MD, PhD Hospital of the University of Pennsylvania University of Washington Sandra Polin, MD Robert Schmidt, MD,Gillean Newstead, MD Georgetown University University of Chicago Elizabeth Morris, MD Pat Bolan, Ph.D., Michael Garwood, Ph.D. Memorial Sloan Kettering Cancer Center University of Minnesota Wanda Bernreuter, MD University of Alabama Version Date: March 8, -
Current Landscape of Breast Cancer Imaging and Potential Quantitative Imaging Markers of Response in ER-Positive Breast Cancers Treated with Neoadjuvant Therapy
cancers Review Current Landscape of Breast Cancer Imaging and Potential Quantitative Imaging Markers of Response in ER-Positive Breast Cancers Treated with Neoadjuvant Therapy Ella F. Jones 1,* , Deep K. Hathi 1, Rita Freimanis 1 , Rita A. Mukhtar 2, A. Jo Chien 3, Laura J. Esserman 4, Laura J. van’t Veer 3, Bonnie N. Joe 1 and Nola M. Hylton 1 1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94115, USA; [email protected] (D.K.H.); [email protected] (R.F.); [email protected] (B.N.J.); [email protected] (N.M.H.) 2 Department of Surgery, University of California, San Francisco, CA 94115, USA; [email protected] 3 School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA; [email protected] (A.J.C.); [email protected] (L.J.v.V.) 4 Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA; [email protected] * Correspondence: [email protected] Received: 19 May 2020; Accepted: 5 June 2020; Published: 9 June 2020 Abstract: In recent years, neoadjuvant treatment trials have shown that breast cancer subtypes identified on the basis of genomic and/or molecular signatures exhibit different response rates and recurrence outcomes, with the implication that subtype-specific treatment approaches are needed. Estrogen receptor-positive (ER+) breast cancers present a unique set of challenges for determining optimal neoadjuvant treatment approaches. There is increased recognition that not all ER+ breast cancers benefit from chemotherapy, and that there may be a subset of ER+ breast cancers that can be treated effectively using endocrine therapies alone. -
1.Title Page
.', '•Cpmpm$9-n of Tlsstie BifBtaioA "•'; E%h-pmluti&xi- aad iSlMd^/pili^siQ^^Psp^ Imagmg In ;: •• Fatlapts • wit a Leeal|y: ;AdA:adavF: B? past: Gaasay la M :V:::l'i11EAl:S:^l-':.';:; SiPpEtpd ;m paMs J satisfadtipa dClMaAspFJtany^ :of. MAST BE &£ ;8g}ffiGGE EkmGtl pal; I PGgldg la If a GIEAldsIAf E B1¥IA1CM: ii DEDICATION I dedicate this thesis to my family for nursing me with affections and love & the living memories of my grandparents. ACKNOWLEDGMENTS I am grateful to my advisor Dr. Nola Hylton for her invaluable guidance and constant encouragement. I express sincere gratitude to Dr. Ella Jones without whose support and suggestions this work would have been difficult. I would like to thank Dr. Lisa Wilmes for many engaging and interesting discussions. I specially thank Rebekah Mclaughlin for assisting my thesis writing enormously. I thank David Newitt and Evelyn Proctor who assisted a lot in this study. iii Comparison of Tissue Diffusion Measurements Using High-resolution and Standard Diffusion Tensor Imaging in Patients with Locally Advanced Breast Cancer Cheng-Liang Liu1 1UCSF Masters of Science in Biomedical Imaging Program, San Francisco, California ABSTRACT Objective: To evaluate fractional anisotropy (FA) in comparison to apparent diffusion coefficient (ADC) for discriminating between cancer and normal breast tissue using standard and high resolution diffusion tensor imaging (DTI). Materials and Methods: Dynamic contrast enhanced MRI, standard DTI, and high- resolution DTI data were collected in ten patients with locally advanced breast cancer before the start of neoadjuvant treatment. Regions of interest were selected in tumor and ipsilateral normal tissue. -
ADC As an Early Indiahor of Response to Neoadjuvant Therapy
ADC as an early indiaHor of response to neoadjuvant therapy I HhSfh Utbmtued in partial satisfaction of the revustrenseitis lbs' the deexee of MASTER OF SCIENCE RADUATE DIVISION UNIVERSITY OF CALIFORNIA, SAN FRANCISCO ! ii Acknowledgement I would like to thank my advisor Dr. Nola Hylton and Dr. Ella Jones, for exposing me to the field of Breast MR and for their guidance and direction both professionally and personally. I would like to thank Jessica Gibbs, whose attention to detail and constant optimism was indispensable. Thank you to Dr. David Newitt, for being generous with his time and helping me work through IDL issues. I am grateful to Dr. Wen Li and Dr. Lisa Wilmes, for sharing their knowledge and expertise with me, and for many engaging intellectual conversations. I would like to thank Dr. Roland Krug, Dr. Alastair Martin, and Dr. Viola Rieke for their guidance and time as members of my thesis committee. Lastly I would like to thank my family and friends for their support as I completed this work. ! iii ADC as an early indicator of breast cancer response to neoadjuvant treatment Elizabeth Li Abstract Quantitative MRI can accelerate drug development by providing non-invasive methods to determine treatment response. The primary aim of this study is to assess the change in normalized apparent diffusion coefficient values (ΔADCN), derived from diffusion- weighted MRI (DWI), as an alternative method to standard dynamic contrast-enhanced (DCE) MRI for assessing response of primary breast tumors to neoadjuvant chemotherapy. Secondary aims are to: assess the influence of image quality scoring on the predictive performance of ΔADCN; test correlations between ΔADCN and change in functional tumor volume (ΔFTV) at early (ΔFTV2) and late (ΔFTV4) time points; and assess ΔADCN of responders versus non-responders. -
11Th Annual RADIOLOGY IMAGING RESEARCH SYMPOSIUM October 21, 2014
UCSF Department of Radiology and Biomedical Imaging 11th Annual RADIOLOGY IMAGING RESEARCH SYMPOSIUM October 21, 2014 Organizers: Peder Larson, PhD, Jing Liu, PhD, Katherine Murphy, and Brad Nakano Acknowledgements: Michael Evans, PhD, K. Pallav Kolli, MD, Roland Krug, PhD, Xiaojuan Li, PhD, Sharmila Majumdar, PhD Susanne Mueller, PhD, Andrew Phelps, MD, Elissa Price, MD, Viola Rieke, PhD, David Saloner, PhD Vivek Swarnakar, Duygu Tosun-Turgut, PhD, Khai Vu, MD, Esther Yuh, MD, PhD, Xiaoliang Zhang, PhD Research Interest Groups Research Interest Groups (RIGs) bring together departmental PhD and MD research and clinical faculty, as well as trainees across our campuses into synergized research groups. They provide a structure for PhD faculty akin to Clinical Sections for purposes of improving departmental visibility and connection. Each group is typically led by a PhD Director and MD Co-Director, who collectively (with their SRG colleagues) form an Executive Research Council. Body RIG: John Kurhanewicz, PhD (Director) Z. Jane Wang, MD (Co-Director) Brain RIG: Sarah J. Nelson, PhD (Director) Srikantan Nagarajan, PhD (Co-Director) Pratik Mukherjee, MD, PhD (Co-Director) Breast Cancer RIG: Nola Hylton, PhD (Director) Bonnie N. Joe, MD, PhD (Co-Director) Cardiovascular RIG: David Saloner, PhD (Director) Karen Ordovas, MD (Co-Director) Musculoskeletal RIG: Sharmila Majumdar, PhD (Director) Thomas Link, MD, PhD (Co-Director) Neurodegenerative RIG: Pratik Mukherjee MD, PhD (Co-Director) Norbert Schuff, PhD (Co-Director) Pediatrics/Fetal RIG: A. James Barkovich, MD (Director) Specialized Resource Groups Specialized Resource Groups (SRGs) bring together departmental PhD and MD research and clinical faculty, who do technique development. Each group is typically led by either a PhD or MD Director, who collectively (with their RIG colleagues) form an Executive Research Council. -
Height, Adiposity and Body Fat Distribution and Breast Density in Young Women
University of Massachusetts Medical School eScholarship@UMMS Open Access Articles Open Access Publications by UMMS Authors 2012-07-16 Height, adiposity and body fat distribution and breast density in young women Joanne F. Dorgan Fox Chase Cancer Center Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/oapubs Part of the Life Sciences Commons, and the Neoplasms Commons Repository Citation Dorgan JF, Klifa C, Shepherd JA, Egleston BL, Kwiterovich PO, Himes JH, Gabriel KP, Van Horn L, Snetselaar LG, Stevens VJ, Barton BA, Robson AM, Lasser NL, Deshmukh S, Hylton NM. (2012). Height, adiposity and body fat distribution and breast density in young women. Open Access Articles. https://doi.org/10.1186/bcr3228. Retrieved from https://escholarship.umassmed.edu/oapubs/2313 This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Open Access Articles by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Breast Cancer Research This Provisional PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. Height, adiposity and body fat distribution and breast density in young women Breast Cancer Research 2012, 14:R107 doi:10.1186/bcr3228 Joanne F Dorgan ([email protected]) Catherine Klifa ([email protected]) John A Shepherd ([email protected]) Brian L Egleston -
Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer by Sheye Oluwaseun Aliu a Dissertation Submitted In
Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer by Sheye Oluwaseun Aliu A dissertation submitted in partial satisfaction of the requirements for the degree of Joint Doctor of Philosophy with the University of California, San Francisco in Bioengineering in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Nola M. Hylton, Chair Professor Steven M. Conolly Professor Marian C. Diamond Fall 2009 Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer © 2009 by Sheye Oluwaseun Aliu Abstract Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer by Sheye Oluwaseun Aliu Joint Doctor of Philosophy in Bioengineering with the University of California, San Francisco University of California, Berkeley Professor Nola M. Hylton, Chair As of the time of this writing, the gold standard for monitoring primary breast tumor response to chemotherapy treatment is clinical examination based on palpable changes in tumor size. This method is non–quantitative, highly subjective and generally imposes that treatment is completed before efficacy can be assessed, defeating the purpose of monitoring and eliminating the prospect of adaptive treatment. MRI methods including tissue enhancement kinetics are increasingly used to provide improved monitoring of treatment response in breast and other cancers. In this work, I investigate the added value of diffusion weighted imaging, an MRI technique, for treatment monitoring in breast cancer. This investigation was first conducted in a thoroughly characterized animal model of breast cancer and subsequently in breast cancer patients. I furthered this work by exploring the potential benefit of diffusion tensor imaging, an MRI technique relatively novel to breast imaging, for breast cancer treatment monitoring. -
Vol. 42, No. 4, October 2015
JMRI J OURNAL OF M AGNETIC R ESONANCE I MAGING CME Article 855 Clinical Applications of Dual-Channel Transmit MRI: A Review Wyger M. Brink, Vikas Gulani, and Andrew G. Webb Review Articles 870 Congenital Heart Disease Assessment With 4D Flow MRI Shreyas S. Vasanawala, Kate Hanneman, Marcus T. Alley, and Albert Hsiao 887 Motion Artifacts in MRI: A Complex Problem With Many Partial Solutions Maxim Zaitsev, Julian Maclaren, and Michael Herbst Original Research Breast 902 Computational Approach to Radiogenomics of Breast Cancer: Luminal A and Luminal B Molecular Subtypes Are Associated With Imaging Features on Routine Breast MRI Extracted Using Computer Vision Algorithms Lars J. Grimm, Jing Zhang, and Maciej A. Mazurowski 908 Gradient Nonlinearity Correction to Improve Apparent Diffusion Coefficient Accuracy and Standardization in the American College of Radiology Imaging Network 6698 Breast Cancer Trial David C. Newitt, Ek T. Tan, Lisa J. Wilmes, Thomas L. Chenevert, John Kornak, Luca Marinelli, and Nola Hylton 920 MRI Phenotype of Breast Cancer: Kinetic Assessment for Molecular Subtypes Eric Blaschke and Hiroyuki Abe Head and Neck 925 Acceleration of MRI of the Vocal Tract Provides Additional Insight Into Articulator Modifications Michael Burdumy, Louisa Traser, Bernhard Richter, Matthias Echternach, Jan G. Korvink, Jurgen€ Hennig, and Maxim Zaitsev 936 Dynamic Contrast-Enhanced MRI Evaluates the Early Response of Human Head and Neck Tumor Xenografts Following Anti-EMMPRIN Therapy With Cisplatin or Irradiation Hyunki Kim, Yolanda E. Hartman, Guihua Zhai, Thomas K. Chung, Melissa L. Korb, Timothy M. Beasley, Tong Zhou, and Eben L. Rosenthal Cardiac 946 Patient Adaptive Maximal Resolution Magnetic Resonance Myocardial Stress Perfusion Imaging David P. -
ISMRM Workshop on Breast MRI: Advancing the State of The
BRIDGING THE GAP BETWEEN CLINICAL NEEDS AND TECHNOLOGICAL SOLUTIONS ISMRM COMMUNITY FOR CLINICIANS International Society for Magnetic Resonance in Medicine www.ismrm.org AND SCIENTISTS ISMRM WORKSHOP SERIES 2018 GROUNDBREAKING MR SCIENCE • SUPERIOR MR EDUCATION • GLOBAL NETWORKING ISMRM Workshop on Breast MRI: Advancing the State of the Art In Affiliation with the Society of Breast Imaging (SBI) & European Society of Breast Imaging (EUSOBI) Las Vegas, NV, USA • 10–13 September 2018 TARGET AUDIENCE: This workshop is targeted towards basic scientists and physicians using MR in breast disease diagnosis and research; clinicians (oncologists, radiologists, pathologists, surgeons, radiation oncologists); and Ph.D. students or residents starting in the field of breast imaging. COMMITTEE CHAIR Elizabeth Morris, M.D., F.A.C.R. Memorial Sloan-Kettering Cancer Center OVERVIEW EDUCATIONAL OBJECTIVES New York, NY, USA This workshop aims to gather technical and Upon completion of this activity, participants COMMITTEE clinical experts in the field of MRI in breast cancer should be able to: diagnosis and management. The advantages and Kristine Glunde, Ph.D. • Describe the standard clinical shortcomings of the current techniques used in Johns Hopkins University implementation and uses for breast MRI; Baltimore, MD, USA breast MRI will be discussed, as well as new and • Recognize possible pitfalls associated Ileana Hancu, Ph.D. emerging approaches in the era of precision GE Global Research Center medicine, such as radiomics, radiogenomics, with the use of MRI in breast disease Niskayuna, NY, USA and big data. Other topics of discussion include management; Thomas Helbich, M.D. correlation of MR imaging findings to epi-/ genomic, • List the factors that can impact image University of Vienna proteomic, transcriptomic and metabolomic quality in breast MRI and list solutions that Vienna, Austria information, and quantitative biomarkers for breast can mitigate such problems; Nola Hylton, Ph.D. -
Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging (DOSI)
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Cancer Manuscript Author Res. Author manuscript; Manuscript Author available in PMC 2017 October 15. Published in final edited form as: Cancer Res. 2016 October 15; 76(20): 5933–5944. doi:10.1158/0008-5472.CAN-16-0346. Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging (DOSI) Bruce J. Tromberg1,*, Zheng Zhang2, Anaïs Leproux1, Thomas D. O’Sullivan1, Albert E. Cerussi1, Philip Carpenter3, Rita S. Mehta4, Darren Roblyer5, Wei Yang6, Keith D. Paulsen7, Brian W. Pogue7, Shudong Jiang7, Peter Kaufman8, Arjun G. Yodh AG9, So Hyun Chung9, Mitchell Schnall10, Bradley S. Snyder11, Nola Hylton12, David A. Boas13, Stefan A. Carp13, Steven J. Isakoff14, and David Mankoff15 on behalf of the ACRIN 6691 investigators Bruce J. Tromberg: [email protected]; Zheng Zhang: [email protected]; Anaïs Leproux: [email protected]; Thomas D. O’Sullivan: [email protected]; Albert E. Cerussi: [email protected]; Philip Carpenter: [email protected]; Rita S. Mehta: [email protected]; Darren Roblyer: [email protected]; Wei Yang: [email protected]; Keith D. Paulsen: [email protected]; Brian W. Pogue: [email protected]; Shudong Jiang: [email protected]; Peter Kaufman: [email protected]; Arjun G. Yodh AG: [email protected]; So Hyun Chung: [email protected]; Mitchell Schnall: [email protected]; Bradley S. Snyder: [email protected]; Nola Hylton: [email protected]; David A. Boas: [email protected]; Stefan A. Carp: [email protected]; Steven J. -
Acknowledgements Learning Objectives
Acknowledgements Radiology • Scott Graham Breast Cancer Advocates • Nola Hylton • Chloee Wendorf • Susie Brain • Dian Heditsian • Bonnie Joe • Michael White • MRI and PET Imaging Markers For Kim Ray • Jim Slater Funding Support • Deep Hathi • Salma Javin • Mt. Zion Health Fund Prediction of Treatment Response in • Margarita Watkins • Henry VanBrocklin • Breast Oncology Program • Wen Li Breast Care Center • Breast Cancer Patients • David Newitt Give Breast Cancer a Boot • Laura Esserman • Youngho Seo • Susan G. Komen SAC110017 Ella F. Jones, PhD • Rita Mukhtar • Ben Franc • NIH/NCI U01CA151235 [email protected] • Jo Chien • Rob Flavell • NIH/NCI P01CA210961 • Ruby Gao 4/20/2021 • Miguel Pampaloni • NIH/NCI R01CA227763 • Julissa Melina‐Vega • Courtney Lawhn‐Heath • DOD W81XWH‐18‐1‐0671 Breast cancer patients and their families 4/20/2021 2 Learning objectives Neoadjuvant chemotherapy (NAC) in breast cancer National Surgical Adjuvant Breast and Bowel Project (NSABP): protocol B‐18 and B‐27 . How imaging markers are used in the neoadjuvant treatment trial . No difference in disease‐free survival or overall survival in patients . MRI markers for the prediction to treatment response and recurrence receiving neoadjuvant chemotherapy with AC or AC + taxane compared to free survival those receiving adjuvant therapy . Use of PET molecular imaging markers to inform assess early treatment . Opportunities Clinical Trial Model response and drug selection • Assess the intact primary tumor and refine treatment • Understand tumor biology in responseAdjuvant to treatment Neoadjuvant • DevelopEndpoint new tools for prognosticSurvival assessment Primary tumor • Accelerate new drug development response Timeline Years (5‐20) Months Rastogi et al., JCO, 2008 3 4 1 4/20/2021 [ADD PRESENTATION TITLE: INSERT TAB > HEADER & FOOTER > NOTES AND HANDOUTS] Contrast‐enhanced MR Imaging I‐SPY 1/ACRIN 6657 PI: Esserman and Hylton Pre‐contrast (t ) t Functional tumor volume 0 1 t2 .