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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. THE JOURNAL OF IMMUNOLOGY Volume 139/Number 5, September 1, 1987 Contents

CELLULAR IMMUNOLOGY

E. B. Bell, S. M. Sparshott, M. 1379 The Stable and Permanent Expansion of Functional T Lymphocytes in T. Drayson. and W. L. Ford Athymic Nude Rats aftera Single Injection of Mature T Cells P. A. Campbell, J. M. Collins, 1385 A Spleen-Derived Maturational Factor Allows Immature Thymocytes, Pre- and K. E. Stedman pared as Cells Bearing Low Amounts of Surface Sialic Acid, to Become Cytotoxic T Cells N. Kumagai. S. H. Benedict, G. 1393 Requirements for the Simultaneous Presenceof Phorbol Esters andCalcium B. Mills, and E. W.Gelfand Ionophores in the Expression of Human T Lymphocyte Proliferation Re- lated Genes A. M. Van Buskirk and H. 1400 In Vitro of Specific Helper and SuppressorT Cells by the Type 2 Braley-Mullen Antigen Polyvinylpyrrolidone (PVP) D. L. Perkins. J. Michaelson. R. 1406 Selective Elimination of Non-lpr Lymphoid Cells in Mice Undergoing lpr- Downloaded from M. Glaser. and A. Marshak- Mediated Graft-vs-Host Disease Rothstein M. K. Heiskala, 0. Cen.E. 1414 Mechanism of Cell Contact-Mediated Inhibition of Natural Killer Activity Saksela, and T. Timonen G. Doris, C. Mancini, D. Frasca. 1419 Age Restriction in Antigen-Specific Immunosuppression and L. Adorini J. Merino, S. Schunnans. S. Lu- 1426 Autoimmune Syndrome after Induction of Neonatal Tolerance to Alloanti- http://www.jimmunol.org/ zuy. S. Izui, P. Vassalli, and gens: Effects of In Vitro Treatment with Anti-T Cell Subset Monoclonal P.-H. Lambert Antibodies J. B. Splawski and P. E. Lipsky 1432 Antigen-Induced Proliferation and Immunoglobulin A Secretion by a Hu- man-Human Hybridoma N. Maggiano, L. M. Larocca. M. 1438 Expression of T Cell Receptor-a and -p Subunits in Human Thymocytes:An Piantelli, 0. Acuto. and P. Immunocytologic Study Musiani F. J. Ramsdell and S. H. Golub 1446 Generation of Lymphokine-Activated Killer Cell Activity from Human Thy- mocytes by guest on October 1, 2021 S. Yoshida. K. Dorshkind. E. 1454 Abnormalities of B LineageCells Are Demonstrable inLong-Term Lymphoid Bearer, J. J. Castles, A. Bone Marrow Cultures of New Zealand Black Mice Ahmed, and M. E. Gershwin P. Lebrun and H. L. Spiegelbeg 1459 Concomitant Immunoglobulin and Immunoglobulin G1 Formation in Nip- postrongylus brasiliensis-InfectedMice

CLINICAL IMMUNOLOGY 0 IMMUNOPATHOLOGY

P. L. Cohen, R. L. Cheek, J. A. 1466 The Subclass Distribution of Human IgG Rheumatoid Factor Hadler, W. J. Yount, and R. A. Eisenberg J. J. Proust, C. R. Filburn, S. 1472 Age-Related Defect inSignal Transduction during LectinActivation of A. Harrison, M. A. Buchholz, Murine T Lymphocytes and A. A. Nordin M. D. Chapman, P. W. Hey- 1479 Epitope Mapping of Two Major Inhalant Allergens, Der p I and Derf I, from mann. and T. A. E. Platts- Mites of theGenus Dermatophagoides Mills S. Sriram, D. J. Topham. and 1485 Haplotype-Specific Suppression of Experimental Allergic Encephalomyelitis L. Carroll with Anti-IA Antibodies

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THE JOURNAL OF IMMUNOLOGY (ISSN 0022- 1767)is published twice each month by The American Association of Immunologists. 428 East Preston Street, Baltimore. MD 21202. Subscription rates $150 ($205 foreign]: institutions $170 ($225 foreign): students $41($96 foreign): single copy $8 ($1 1 foreign). Indexed by Current Contents and Index Medicus. Second class postage paid at Baltimore. MD 21202 and at additional mailing offices.POSTMASTER: Send address changesto The Journalof Immunology at 428 East Preston Street.Baltimore. MD 21202. Copyright 0 1987 by The American Association of Immunologists. Continued from page 3 C. G. Romball and W. 0. Weigle 1490 The Effect of Aging on the Induction of Experimental Autoimmune Thy- roiditis R. S. Balderas. 0. Josimovic- 1496 Elevated Titers of Cell-Free Interleukin 2 Receptor in Serum of Lupus Mice Alasevic, T. Diamantstein,F. J. Dixon, and A. N. Theofilo- poulos N. K. Damle, A. L. Chi1ds;and 1501 Immunoregulatory T Lymphocytes in Man: Soluble Antigen-Specific Sup- L. V. Doyle pressor-Inducer T Lymphocytes Are Derived from the CD4'CD45R-p80+ Subpopulation K. Ishibashi, S. Hanada, and S. 1509 Expression ofHTLV-I in Serum of HTLV-I-Related Subjects and the Early Hashimoto Detection of Overt ATL in HTLV-I Carriers B. A. Woda and C. Padden 1514 Biobreeding/Worchester (BB/Wor)Rats Deficient in the Generation of Func- tional Cytotoxic T Cells E. G. Neilson, C. J. Kelly, M. D. 1518 Murine Interstitial Nephritis. VII. Suppression of Renal Injury after Treat- Clayman. W. H. Hines, T. ment with Soluble Suppressor Factor TsFl Haverty, M. J. Sun. and N. Blanchard

CYTOKINES MEDIATORS REGULATORYMOLECULES Downloaded from

D. L. Ennist, K. L. Elkins, S. C. 1525 Activity of a Partially Purified Human BCGF On Murine Assays for B Cell Cheng. and M. Howard Stimulatory Factors. 11. Synergy between Two Distinct BCGF 11-Like Fac- tors in Promoting B Cell Differentiation S. N. Ho, R. T. Abraham, A. 1532 Interleukin 1-Mediated Activation of (IL-4)-ProducingT Lym- Nilson. B. S. Handwerger, phocytes: Proliferation by IL-4-Dependent and IL-4-Independent Mecha-

and D. J. McKean nisms http://www.jimmunol.org/ P. Seckinger, K. Williamson, 1541 A Urine Inhibitor of Interleukin 1 Activity Affects Both Interleukin la and J.-F. Balavoine, B. Mach, G. 1B But Not a Mazzei, A. Shaw. and J.-M. Dayer P. Seckinger. J. W. Lowenthal. 1546 A Urine Inhibitor of Interleukin 1 Activity that Blocks Ligand Binding K. Williamson, J.-M. Dayer. and H. R. MacDonald L. T. Bich-Thuy. M. Dukovich. 1550 Direct Activation of Human Resting T Cells by IL 2: The Role of an IL 2 N. J. Peffer. A. S. Fauci, J. H. Receptor Distinct from the TAC Protein Kehrl, and W. C. Greene by guest on October 1, 2021 D. V. Messadi. J. S. Pober. W. 1557 Induction of an Activation Antigen on Postcapillary Venular Endothelium Fiers, M. A. Gimbrone, Jr., in Human SkinOrgan Culture and G. F. Murphy Y. Richard, C. Leprince. B. Du- 1563 Reactivity of LEU-l+ Tonsillar B Cells to a High Molecular Weight B Cell gas, D. Treton, and P.Gal- Growth Factor anaud

IMMUNOCHEMISTRY

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P. A. Rosa, D. S. Sepich. D. M. 1568 Constitutive Expression of Slp Genes in Mouse Strain B1O.WR Directed by Robins, and R. T. Ogata C4 Regulatory Sequences B. S. Fox, C. Chen. E. Fraga, C. 1578 Functionally Distinct Agretopic and Epitopic Sites: Analysis of the Domi- A. French, B. Singh. and R. nant T Cell Determinant of Moth and Pigeon Cytochromes c with the Use H. Schwartz of Synthetic Peptide Antigens R. A. W. van Lier, J. Borst. T. 1589 Tissue Distribution and Biochemical and Functional Properties of Tp55 M. Vroom. H. Klein, P.Van (CD27).a Novel T Cell Differentiation Antigen Mourik, W. P. Zeijlemaker, and C. J. M. Melief W. C. Hanly. L. Cook. M. King- 1597 Rabbit Secretory Components: Identification of a Third Allotype, t63 zette. W. Cox, s. Frutiger, G. J. Hughes, and J.-C. Jaton S. Hosoi. A. Circolo, and T. Bor- 1602 Activation of Human C 1: Analysis with Western Blotting Reveals Slow Self- SOS Activation D. P. Snider and D. M. Segal 1609 Targeted Antigen Presentation Using Cross-linked Antibody Heteroaggre- gates Continued on page5 Continued from page 4

IMMUNOPHARMACOLOGY

M. Iitaka, Y. Iwatani, V. V. Row. 161 7 Induction of Monocyte Procoagulant Activity with OKT3 Antibody and R. Volpk M. V. White and M. A. Kaliner 1624 Neutrophils and Mast Cells. I. Human Neutrophil-Derived Histamine-Re- leasing Activity K. M. Skubitz and R. W. Snook 1631 Monoclonal Antibodies that Recognize Lacto-N-fucopentaose 111 (CD15) I1 React with the Adhesion-Promoting Glycoprotein Family (LFA-l/HMAC- l/GP 150.95) andCR1 on Human Neutrophils H. R. Katz, J. S. Levine. and K. 1640 Interleukin3-Dependent MouseMast Cells Express the Cholera Toxin- F. Austen Binding Acidic Glycosphingolipid, Ganglioside G,, , and Increase Their Histamine Content in Response toToxin

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M. F. Lima and F. Kierszen- 1647 Lactoferrin Effects on Phagocytic Cell Function. 11. The Presence of Iron Is baum Required for the Lactoferrin Molecule to Stimulate IntracellularKilling by Macrophages But Not to Enhance the Uptake of Particles and Microorga- nisms R. B. Lal, T. J. Lynch, and T. 1652 Brugia malayi Antigens Associated with Lymphocyte Activation in Filari- B. Nutman asis http://www.jimmunol.org/ A. Charbit. E. Sobczak. M.-L. 1658 Presentation of Two Epitopes of the preS2 Region of Hepatitis B Virus on Michel, A. Molla, P. Tiollais. Live Recombinant Bacteria and M. Hofnung J. T. van Dissel, J. J. M. Stik- 1665 Divergent Changes in Antimicrobial Activity after Immunologic Activation kelbroeck. M. Th.van den of Mouse Peritoneal Macrophages Barselaar, W. Sluiter, P. C. J. Leijh. and R. van Furth J. T. van Dissel, J. J.M. Stik- 1673 Inability of Recombinant Interferon-y to Activate the Antibacterial Activity kelbroeck, B. C. Michel, M. of Mouse Peritoneal Macrophages against Listeria rnonocytogenes and

Th. van den Barselaar. P. C. Salmonella typhirnuriurn by guest on October 1, 2021 J. Leijh, and R. van Furth P. Romero, E. P. Heimer, S. Her- 1679 Antigenic Analysis of the Repeat Domain of the Circumsporozoite Protein rera. A. M. Felix, R. S. Nus- of Plasmodium viuax senzweig, and F. Zavala

MOLECULARBIOLOGY MOLECULAR GENETICS

K.4. Yamamoto, N. Goto. J. Ko- 1683 Structural Diversity of Murine Serum Amyloid A Genes: Evolutionary Im- saka, M. Shiroo, Y. D. Yeul. plications and S. Migita S. Hoch and J. Scharaber 1689 Identification and Sequence of the VH Gene Elements Encoding a Human Anti-DNA Antibody S. H. Benedict, G. B. Mills, and 1694 Interleukin 2 Activates a Receptor-Associated Protein Kinase E. W.Gelfand M. P. Stenzel-Poore, T. J. Hall, 1698 Immunologic Memory to PC-KLH: Participation of the Q52 VHGene Family C. H. Heusser, C. H. Faust, and M. B. Rittenberg C. A. Biron, P. van den Elsen. 1704 Murine Natural Killer Cells Stimulated In Vivo Do Not Express the T Cell M. M. Tutt, P. Medveczky, V. Receptor CY, /3, y. T36, or T3t Genes Kumar, and C. Terhorst

Continued on page 6 Continued from page 5 Y. ha. Y. Koide. N. Nezu, and 171 1 Regulation ofHLA Class I1 AntigenExpression: Intracellular Signaling T. 0. Yoshida Molecules Responsible for the Regulation by IFN-y and Cross-Linking of Fc Receptors inHL-60 Cells C. Nottenburg, T. St. John,and 1718 UnusualImmunoglobulin DNA Sequencesfrom the NonexpressedChro- I. L. Weissrnan mosome of Mouse Normal B Lymphocytes: Implications for Allelic Exclu- sion and theDNA Rearrangement Process P. P. Chen, K. Albrandt. T. J. 1727 Isolation and Characterization of Human VkIII Germ-Line Genes: Implica- Kipps, V. Radow, F.-T. Liu, tions for theMolecular Basis of Human VkIII Light Chain Diversity and D. A. Carson

TUMOR IMMUNOLOGY

N. E. Street, R. J. Fulton, V. M. 1734 Inhibition of the Helper Function of Murine T Cells with Fab’-Anti-L3T4 Sanders, andE. S. Vitetta Ricin A Chain Immunotoxin R. c.Roozemond. M. Mevissen, 1739 Effect of Altered Membrane Structure onNK Cell-Mediated Cytotoxicity. 111. D. C. Urli, and B. Bonavida Decreased Susceptibility to Natural Killer Cytotoxic Factor (NKCF) and Suppression of NKCF Release by Membrane Rigidification

Erratum 1747 Downloaded from

Announcements 1747 Author Index Author 1749 http://www.jimmunol.org/ by guest on October 1, 2021